[[quoteright:320:[[Series/{{Smallville}} http://static.tvtropes.org/pmwiki/pub/images/320px-Blue_K_kills_Bizarro_5688.jpg]]]]
[[caption-width-right:320:Oops... guess the blue kryptonite is a little too much to handle...]]

->'''Zola:''' Violetta, you pathetic loser! Did you just try to ''poison'' me? Ahahahaha! As if that could stop me now!\\
'''Violetta:''' I know that. That wasn't poison, that was more Movit 11. Now all I have to do is watch you combust.
-->-- ''Webcomic/GirlGenius''

AppliedPhlebotinum is useful, so [[TimTaylorTechnology applying more phlebotinum should be more useful]], right?

Wrong! When the amount of phlebotinum [[GoingCritical reaches critical mass]], bad things happen. Maybe it summons an EldritchAbomination, maybe it makes a [[NegativeSpaceWedgie black hole]], maybe it [[ExplosiveOverclocking goes more and more unstable]] and eventually [[StuffBlowingUp blows up]]. If the phlebotinum was already dangerous, expect the danger to increase exponentially.

May cross over with {{Aesoptinum}} when the {{Aesop}} is "All things in moderation." Not to be confused with PhlebotinumOverload. SuperpowerMeltdown is this on the individual level. See also GoingToGiveItMoreEnergy. Compare PentUpPowerPeril where the power comes from the inside, rather than the outside, but ends with similar results if care is not taken.


* In the film ''WesternAnimation/DotAndTheKangaroo,'' the Kangaroo warns Dot not to eat too much of the root that allows her to [[SpeaksFluentAnimal talk to animals]] because if she does she'll "know too much," which will make her "miserable."
* As evident in ''Film/GodzillaVsDestoroyah'', if Franchise/{{Godzilla}} absorbs too much radiation or if his body-temperature goes too high, he risks going into critical mass and could either explode and/or go into a meltdown. Either way, it's VERY bad news for the rest of the world.
* ''Film/TheLeagueOfExtraordinaryGentlemen''. An enemy {{Mook}} drinks an entire beaker of Dr. Jekyll's potion (Jekyll's dose fits in a vial) and grows into a berserk monstrosity [[UpToEleven that makes Mr. Hyde look normal]] (and that's saying something).
-->'''Jekyll/Hyde''': "It's me on a bad day."
* ''Film/SantaClausTheMovie'' (1985) has stardust as the phlebotinum in question: Adding it to their fodder gives Santa's reindeer their flying abilities. When elf inventor Patch journeys to the human world to prove his worth to Santa, he creates a lollipop that has a bit of stardust as an ingredient; whoever eats one can temporarily fly. They're hugely popular, and the CorruptCorporateExecutive who markets them demands that the follow-up should have more stardust added, so the effects will last longer; the villains subsequently learn that the resultant candy canes ''explode'' if kept near a heat source (i.e., a radiator) too long. This is because the stardust, which originated at the cold North Pole, becomes unstable when exposed to too much heat.
* This is how the BigBad is defeated in the second {{Hoodwinked}} movie.

* The the MagicTheGathering novel Time Spiral, Radha uses this to defeat Greht. She breaks his hold on his horde, he gets if back by starting a ridiculously powerful spell, and Radha starts feeding him more mana. This doesn't end well for him.
* In ''Literature/CharlieAndTheGreatGlassElevator'', Willy Wonka gives the three grandparents who refuse to get out of bed pills which can de-age them exactly 20 years per pill -- they greedily decide that they should split the whole bottle, and because they don't do the math two are rendered babies and one of them ''negative two'' years old. This is played more for horror than humor, as is the result when the negatively aged Grandma Georgina is brought back to this plane of existence via an overdose of an aging serum counterpart -- she's ''several hundred'' years old until a correct dose of the de-aging pills restores her to her original age.
* Magic on Literature/{{Discworld}} has some [[CosmicHorror ugly]] quantity limitations.

* Pictured at the top is Bizarro from ''Series/{{Smallville}}'', who reacts in the opposite manner to kryptonite that Clark does. He gains strength from green kryptonite, which depowers and poisons Clark. When exposed to blue kryptonite, which strips Clark of his powers for as long as it's in contact, he gains a massive power boost and explodes.
* In one ''FantasyIsland'' a woman was given a potion to become beautiful for a time (an hour??) if she took one drop. Complications ensued and she was forcibly made to drink the whole bottle on the grounds that "if one drop is good the whole bottle is better!" She became a harridan.
* ''Series/StarTrekTheNextGeneration'' had an episode where an old diplomat takes his wife's share of age-reversing medication as well as his own.
* The end of "Planet of Spiders" on ''Series/DoctorWho''--[[spoiler: the Great One, leader of the spiders, assembles a web of crystals that contain power--but when she completes it, the power destroys her. Also meant as a metaphor for the ego.]]
** [[spoiler: Those crystals are psychic super amplifiers so not just a metaphor, her ego *is* the power that destroys her]].
* In ''Series/TheOuterLimits1995'' episode "Last Supper", a scientist pursues an immortal woman to unlock the secret of eternal life. He injected a tiny bit of her blood into a rat, which was still alive decades later. As his age had caught up with him, he decided to attempt the same on himself. He drew a little too much blood, however, causing him to de-age into a pre-fetal puddle of human tissue.

[[folder:Tabletop Games]]
* Older versions of ''TabletopGame/DungeonsAndDragons'' has Potion Miscibility. That is if you mixed potions or drank a potion while under the effects of another potion you had to roll on a chart to see what would happen instead of the normal effects. A few of the effects are desirable, but possible effects include explosions and being poisoned.
** ForgottenRealms had a few. Too many strong spells released at once tend to interact abnormally until they form one "spell-storm" on the scale up to FantasticNuke or overload and warp [[TheForce the Weave]] powering them. This way several civil wars among the Drow caused total destruction of their cities, supposedly including the creation of Great Rift -- geographical feature about 170 miles long and 1000 feet deep. [[http://www.wizards.com/default.asp?x=dnd/rl/20060628a Myth Drannor had]] large [[BiggerOnTheInside extradimensional pockets]] built too densely -- enough that they began to interfere, distort magic all around and compromised an originally impenetrable city-scale teleport denial ward -- which becomes Very Bad News during an attack by [[TheLegionsOfHell a whole army of fiends]].
* Many cyberpunk games have some sort of psychological penalty for implanting too much cyberware, such as going insane or dying.
** ''TabletopGame/{{Shadowrun}}'': lowers Essence, losing too much causes death
** ''TabletopGame/{{Cyberpunk}} 2020'': lowers Humanity, losing too much causes Cyberpsychosis
* ''TabletopGame/CallOfCthulhu'' supplement ''Terror Australis'', adventure "Old Fellow That Bunyip". The investigators must drive a bunyip upriver by calling "Eleanba Wunda", the name of a terrifying spirit. Unfortunately, if they say the name too often they may [[SpeakOfTheDevil summon Eleanba Wunda itself]].

* While the ''MetroidPrime'' series has the already ToxicPhlebotinum Phazon, ''Corruption'' gives Samus a way to harness it as [[SuperMode Hypermode]]. If Samus is exposed to large amounts of Phazon or she stays in Hypermode for too long, it overloads and she must dump all of the Phazon in the system or she will [[NonstandardGameOver turn into another]] [[EvilTwin Dark Samus]].
* In ''TheWitcher'', you suffer poisoning when you drink potions. This prevents you from taking too many powerups at once. A justified trope since they ''are'' poisons, many of which are lethal to non-mutated humans, but not to the resistant [[SuperSoldiers Witchers]].
* Overlaps with DealWithTheDevil in ''SoulNomadAndTheWorldEaters''-- using Gig's power too much results in a hostile body takeover, and a NonstandardGameOver.

* ''EerieCuties'' [[http://www.eeriecuties.com/d/20091223.html delivers]] to us: a critical mass of Succubus' [[LovePotion magical pheromone]]. Let's see whether there is such a thing as Armor Piercing Splash Damage to Sanity...
* In ''Webcomic/GirlGenius'' [[McNinja Smoke Knights]] use [[PsychoSerum combat stimulants they call "MoveIt"]]. The highest level Violetta [[http://www.girlgeniusonline.com/comic.php?date=20090211 dared to use on a wounded Tarvek]] was #6, which him run around as new...but as a side effect it made a person that's normally a [[MagnificentBastard subtle schemer]] act [[SuicidalOverconfidence suicidally "heroic"]]. And he didn't look pretty when this stuff wore out. Then [[spoiler:Zola]] drank a dose of #11. That level can be lethal for unprepared people as it is, so Violetta decided she'd have a better chance injecting [[spoiler:Zola]] with an overdose rather than trying any other poisons.

[[folder:Web Original]]
* In ''Literature/{{Phaeton}}'' absorbing too musch mystic energy causes crystal sealing.

* In the ''WesternAnimation/BatmanTheAnimatedSeries'' episode featuring Bane, Batman defeats Bane by sabotaging his Venom pump, causing a massive overdose. This is repeated in two ''WesternAnimation/BatmanBeyond'' episodes: in one episode, "The Winning Edge", Bane's doctor adapts the venom formula into slap-on dermal patches, only to be defeated when Terry knocks him into an entire box of them (followed by an explosion to knock him out); in another episode, "Splicers", a scientist marketing LegoGenetics to create animal people [[OneWingedAngel turns himself into a chimera]] to fight Batman, only to be defeated when Batman doses him with even more of the stuff, causing him to go turn into a [[BodyHorror horrible blob monster]] that [[WhatMeasureIsANonHuman can safely be blown apart on a Saturday morning cartoon]].
* ''IronManArmoredAdventures'' has this in the episode "Best Served Cold". Whitney Stane has been over-using the Madame Masque image inducer, and the phlebotinum that powers it has started to affect her brain. Tony has to travel to the arctic to find the raw ore form of the material to help cure her [[spoiler:but in the end ends up having to use a small amount from the supply that powers his pacemaker.]]
* In ''AdventuresOfTheGummiBears'', the Gummi Glen Gummis at one point corner Toady and he decides to drink a whole keg of Gummiberry Juice and everyone scrambles back for the reaction for that much a dosage. Sure enough, Toady has a massive overdose that leads him to uncontrollably rocketing back to Duke Igthorn empty handed.
* On ''{{Hero 108}}'', Mystique Sonia can grow [[PowerUpFood magic bean buns]] that give the consumer super strength, but in the episode "Lion Castle" she ate too many and just ended up fat and out of shape.

* Spoofed by [[http://www.theonion.com/content/news/sci_fi_writer_attributes this]] [[TheOnion Onion]] article.

* People taking prescription drugs will often grow accustomed to the small amounts they take, and so they overdose when they take more and more to try to compensate. Unfortunately, the ''effective'' dose and the ''safe'' dose are both determined by different factors, and ''don't'' rise at the same rate when it comes to a lot of medications, so doing this means you're liable to, well, overdose. Better to switch up meds.
* all known life on this planet runs on water as a vital component, and you can even overdose on that. It's safe to say that too much of anything we need could be...unpleasant.