->'''Shackleforth:''' "Glove cleaner", huh? Say... you sell much of that stuff?\\
'''Daemon:''' Now and again.\\
'''Shackleforth:''' By the way, what's in it?\\
'''Daemon:''' No trace, no odor, no taste, no way to detect its presence. And it's sure. One thousand dollars...\\
-- ''Series/TheTwilightZone'', "The Chaser"


When murder by poison is depicted in fiction, it never takes more than a drop of clear liquid or a pinch of white powder in order to make the victim grip their throat, cough a bit, and fall over. Quick, clean, and quiet. The reality is not so simple. To kill someone with poison, without arousing suspicion, is a very complex process.

Outside of highly controlled chemical munitions, there are very few substances available to the average murderer that can kill a human being as quickly and easily as the poisons of fiction. Famous poisons like arsenic, strychnine, cyanide, etc. require small, repeated doses to build up enough concentrations to kill without arousing the suspicion of the victim... in significant quantity, such poisons taste extremely bitter (hence the need for medieval food tasters). The mechanisms by which these poisons kill can cause [[NightmareFuel dramatic physical reactions]] in the victim. And these old standby poisons are easily and routinely detected by modern forensic pathology.

The sort of poisons that ''can'' kill very rapidly at small doses tend to be staggeringly dangerous to the poisoner himself, not to mention exceptionally hard to come by and hazardous to manufacture.

There's also the matter of 'getaway time'- a fast-killing poison is more dramatic, but a slow-killing one is harder to link to its source.

This is generally assumed to be the kind of poison used in a case of FingerLickingPoison. Frequently has an ImprobableAntidote. May or may not [[TechnicolorToxin be purple or green]]. Naturally, part of its perfectness is usually that it works on [[UniversalPoison everything.]]
----
!!'''Examples:'''

[[foldercontrol]]

[[folder:Anime and Manga]]
* Averted in ''Manga/JoJosBizarreAdventure'', where both victims [[BigBad Dio]] poisons happen in steady doses over a long time.
* Subverted in ''DetectiveConan''. APTX-4869 is supposed to be one, and for the majority of victims has been, but certainly for our heroes it's merely a FountainOfYouth.
** But they do have quite a few incidents where a person is killed by poison from a single dose administered a short time before the victim dies. You'd think the killers would want their target to drop dead somewhere other than the place they were poisoned, to throw the police off the trail and give them time to dispose of the evidence, but that never occurs to them.
* Partially averted in ''{{Naruto}}'': the Sasori's PoisonedWeapons are said to take three days to kill their victim, though they still take an improbably small amount to do so. At least he has a reason not to be concerned about their being dangerous to him (since he doesn't have a real body, and is thus immune to the effects).
** If it were actually a bio-weapon of some sort, it would explain why it can kill even in small doses, never kills faster, and why it is so difficult to cure. Probably targeting the nervous system, given its paralyzing effects.
*** Another option is Ricin, which usually kills in about 3-5 days. It works by preventing the victim's body from making more protein.
* Averted in ''ShinaDark''. Poisoning Christina was done over many years.
[[/folder]]

[[folder:Fan Fiction]]
* In ''Fanfic/MGLNCrisis'', the poison [[spoiler:Raquel Benna/Zettin drinks]] kills her within a few minutes, before help arrives.
* In ''Fanfic/IfThemsTheRules'', Arcturus poisons his wife, Melania with a perfume. [[spoiler: Played realistically as it takes a course of months for the poison to kill her, as much as a magical poison can be realistic.]]
* In the Dangerverse, [[spoiler:Narcissia Malfoy drinks a poison that gives her twenty fours to live, long enough to do quite a lot of confessing, and taking her out of Draco's life, so he doesn't feel conflicted.]]
[[/folder]]

[[folder:Film]]
* Iocaine powder from ''Film/ThePrincessBride'' is odourless, tasteless, and causes nearly instant death from a dose small enough to avoid detection by the victim in a single glass of wine.
* Aversion of this trope is a major plot point in the second half of Creator/AlfredHitchcock's ''Film/{{Notorious}}.'' [[spoiler:It's even stated outright that the poisoning must be done slowly so outsiders merely think the victim is ill.]]
* TheMaids: A cup of tea mixed with an overdose of sleeping pills will cause the victim to peacefully go to sleep in some ten seconds. (In RealLife, it would probably make the person nauseated enough to vomit the pills back up).
* In ''{{Traffic}}'', the police informant played by Miguel Ferrer dies a few minutes after eating one bite of a poisoned breakfast. The only warning was his comment that the food "tastes like shit."
* The pure heroin that ends up killing Ignacio in ''Film/BadEducation''. Ignacio had become heavily addicted and was spending all of his money to obtain it, so his murderers made his death look like an overdose.
* "Luminous toxin" is the sure-fire poison in ''Film/{{DOA}}''.
* In ''FromRussiaWithLove'', Blofeld pulls his first BlofeldPloy, putting Kronsteen at ease by directing his anger at Rosa Klebb for their operation's failure - then having a mook kick Kronsteen with a poisoned blade. He drops dead in a matter of seconds; Blofeld times it, observing they need to develop a faster-working poison.
* In ''YouOnlyLiveTwice'' a SPECTRE mook, trying to kill Bond, accidentally poisons Aki with a drop of liquid on her lips that kills her in seconds.
* ''That Man from Rio'' begins with a thief stealing an ancient Mesoamerican statuette in a museum, killing a guard instantly with a poison-dart pistol. The police initially suspect cardiac arrest before the dart is discovered.
[[/folder]]

[[folder:Literature]]
* MistressOfTheArtOfDeath: The death cap mushrooms that kill Rosamund in ''The Serpent's Tale'' are mixed in with so many different kinds of harmless mushrooms that it's impossible to tell where they came from.
** Also, one of the effects of the mushrooms' poison is that the victim appears to get better for a time, meaning it is both slow- and fast-acting poison.
* Averted in the ''Literature/{{Discworld}}'' novel ''Discworld/FeetOfClay'', which depicts an attempted arsenic poisoning fairly accurately.
** Even then it wasn't to kill him either. It was to keep him from doing his normal duties.
* V.C. Andrews' novel ''Literature/{{Flowers in the Attic}}'' has a fairly realistic version of this trope: The unwanted children's meals include powdered sugar donuts that contain traces of arsenic. Each donut contains only a minute amount of arsenic so that the children will gradually and inconspiciously die after consumption of a significant number of donuts, and the powdered sugar ensures that they won't taste the poison's bitterness. The children unwittingly hasten the death of one of them by giving him all their powdered sugar donuts because he won't eat much else from the meals.
* Averted in ''Literature/MadameBovary'' by Gustave Flaubert. Emma Bovary attempts to kill herself by swallowing a large dose of arsenic. Instead of instantaneous death, Emma endured several days of intense and gruesome illness before she finally died. Note that this is completely in-character for Emma, who has lived her entire life [[WrongGenreSavvy believing herself the heroine of cheesy romance story]], while unfortunately only being the heroine of a painfully realistic and extremely cynical one.

* In ''Literature/ASongOfIceAndFire'', which has fairly medieval technology, the 'tears of Lys' are a poison that effectively duplicates the effects of a harsh fever, leading to an apparently natural death. However, it's stated that the death takes some weeks, and it may well require repeated dosages. More messily, another poison causes symptoms which resemble anaphylatic shock or choking/suffocation--but the poison is stated to have magic in it, and it may have been sourced from an order of shapechanging assassins, so it may be justified. Other than that, all poisons are detected by food tasters, kill over time, or are not used to kill at all; for example, one character doses another with a poison that leaves her indisposed for a day or two so that he can work uninterrupted.
** [[spoiler:And in the case of the Tears of Lys, it also helped that the Maester in charge of healing the victim knew he was being poisoned and was ordered not to cure him. [[TheCoronerDothProtestTooMuch He subsequently covered up the death as 'death by natural causes']].]]
* Addressed and averted in Simon Spurrier's ''Contract'': the main character and [[ProfessionalKiller hitman]] Michael Point drills holes in his bullets, and notes (in monologue) that conventional wisdom suggests that he fill them with poison so that his targets will die even if they were only winged. However, he goes into great detail as to why most poisons are ineffective for this kind of use, too expensive, or just plain unattainable; eventually, he decides to fill each bullet with a thousand milligrams of pure heroin - dissolved with a drop of lemon juice - in the hope that even a nonlethal shot will result in a fatal overdose.
* Subverted in ''Literature/BestServedCold'' by Joe Abercrombie. The opening scene with the master poisoner Castor Morveer starts with him telling his apprentice about the "King of Poisons", a toxin that is both completely undetectable and impossible to build up an immunity against, and should only be used against someone who is protected against all else to keep the secret. However [[spoiler: much to the apprentice's dismay, the "King of Poisons" is merely a sham concocted by Morveer in case the apprentice betrays him.]]
* Averted in the ''Literature/{{Belgariad}}'', where there is ''no'' such thing as a symptomless poison, at least to someone who's familiar with them. In fact, most poisons kill in somewhat over-the-top manners. The closest there is to a "perfect" poison, thalot (a guaranteed kill even against magic, because it poisons ''everything'' in the victim's body), takes several days to finish off the victim.
** [[spoiler:And then we find out that Garion accidentally created an antidote for thalot several books earlier.]]
* Subverted in ''Literature/{{Dune}}: House Atreides'', where Hasimir Fenring poisons Emperor Elrood Corrino IX at the request of the Emperor's son Shaddam with a chaumurky (poison that goes in a drink) that takes two years to work. The poison requires constant consumption of spice beer in order to work. Fortunately for the assassin, Elrood loves spice beer. Also, the effects of chaumurky become apparent within weeks, as the aging Emperor slowly begins to exhibit symptoms similar to senility. Given his advanced age, nobody suspects foul play.
** The Water of Life plays with this trope. The extract from a juvenile sandworm is supposed to be ''so'' dangerous that ''just one drop'' would cause sudden, violent death. It is the mark of a truly gifted individual to be able to overcome the poison, which requires enough control of the body to be able to transmute the toxin within into a non-lethal psychotropic. A woman who can achieve this has the makings of a full-fledged Bene Gesserit. A ''man'' who can achieve the same...has the makings of ''TheChosenOne''.
* In Creator/RobertEHoward's ''Literature/ConanTheBarbarian'' story "Literature/TheTowerOfTheElephant" Taurus kills several lions by blowing a powder at them.
* ''Creator/TomClancy's'' ''[[Literature/JackRyan The Teeth of the Tiger]]'' uses this form of instant undetectable poison.
* The short story "The Poison Necklace" revolves around the eponymous necklace, the jewels of which are crystallized forms of various extremely toxic substances. The deaths it causes are nearly impossible to diagnose because the necklace looks entirely harmless, and the effects don't match any known poison. It was created solely as a science project, handled with gloves and kept under a bell jar, never meant to be worn.
* Subverted in Creator/IsaacAsimov's ''TheNakedSun''. A poisoning is attempted, but any kind of murder, let alone murder by poison, is so unheard of on Solaria that the attempt fails. The would-be assassin used too much poison, and the victim vomited it up before it could kill him.
* Done right for once in ''Literature/CodexAlera''. [[spoiler: The Emperor]] was fed small amounts of poison for years by [[spoiler: his wife]], allowing it to gradually build up in his system. The effects of the poison are so slow that the victim thinks that the discomfort and pain are merely signs that he's getting old.
* Averted in ''[[Literature/CircleOfMagic Street Magic]]''; the villain commits suicide by quick-acting poison to evade the authorities, and Briar finds the body and identifies the poison by scent, indicating that it was taken straight. In addition, he can tell from [[spoiler: Lady Zenadia's]] body language that it was a painful death.
* ''Literature/TheSagaOfTheVolsungs'': Sinfjotli drops dead instantly after drinking a cup of poisoned ale.
* Played with in ''Literature/HungerGames''. Played straight with the Nightlock berries- they result in instant death to whomever consumes them. Subverted with the venoms President Snow used to poison his enemies- they did kill the enemies, but they also gave Snow sores in his mouth even when he took the antidotes.
[[/folder]]

[[folder:Live Action TV]]
* ''Series/TheBorgias'' likes this trope.
* The TV forensic show ''Forensic Files'' -- which focuses on real-life law enforcement officers solving real-life crimes without HollywoodScience forensics -- throws this trope up in the air in several episodes where a person has survived doses of poisons magnitudes larger than it would take to kill a person simply because they had been given small does over periods of years and had built up a tolerance to it. Cut to a graph of "Here's what would kill a normal person" and, six inches higher on the graph, "Here's where his/her levels were".
* Subverted in ''TheTenthKingdom'', where it was established that the Wicked Queen killed Snow White's mother by slowly poisoning her as her handmaid, then married Snow White's father and did the same to him. The same was done to Prince Wendall's parents by the new [[WickedStepmother stepmother]].
* Subverted in an episode of ''Series/{{CSI}}''. The [=CSIs=] spend most of the episode looking for the instant poison that likely killed a high-stakes poker player. Grissom realizes at the end that it was a combination of factors -- a "lucky" bullet stuck in his leg he never took out, plus a daily regimen of chocolates grown in a country where the cars use leaded fuel -- that built up to create a serious medical condition. The guy was 'poisoned' with eye drops which in a regular person would have simply induced diarrhea. The lead in his system made the eye drops deadly.
* ''Series/IClaudius'', has a number of poisoners, all of whom dose their victims over a number of days to make it seem like they died of a wasting illness. One of the poisoners, Martina, advises a client against using the tasteless belladonna as a poison since it leaves a tell-tale rash, but the client doesn't listen and uses it anyway. (This later comes back to haunt said client, when she and her husband are brought in for murder charges.)
* Both the above-quoted ''Series/TwilightZone'' episode and the story it's based on have "glove cleaner", "totally undetectable to all forms of autopsy". The man who sells it also sells love potions... for five dollars. He's expecting all of his customers to come back for the "glove cleaner"...
* In the ''Series/DoctorWho'' episode "[[Recap/DoctorWhoS32E8LetsKillHitler Let's Kill Hitler]]", Melody Pond poisons the Doctor with a single kiss wearing lipstick containing the Poison of the Judas Tree. It's not instantly fatal, but it's perfect in the sense that it disables Time Lord Regeneration as well as killing the body. And it's non-toxic to Melody, [[AvertedTrope averting]] the UniversalPoison trope.
* In ''Series/{{Justified}}'', Mags Bennett kills one of her henchman with poisoned moonshine. The unidentified poison killed him in under two minutes, and he apparently didn't detect any smell or taste.
* Averted in ''Series/BoardwalkEmpire''. The Commodore was poisoned with rat poison over a long period of time and in high quantities. While he is left violently ill and has to regrow his stomach lining, he still recovers to full health a few months later.
* In ''Series/BreakingBad'', Walt cooks up a little ricin to deal with Tuco. It's odorless, tasteless, requires an extremely small dose, kills within a few days after at first appearing like the flu, and is so rare it isn't tested for. Later in the series, Jesse keeps around a "lucky cigarette" filled with the stuff, just in case. [[spoiler:Ricin is used for actual poisoning only once, in the last episode of the series: Walt puts it into Lidia's tea, killing her.]]
** Later on, Gus [[spoiler:kills Don Eladio and all of his capos with a bottle of poisoned tequila. He drinks some himself, and goes to the bathroom to force himself to vomit in order to avoid the worst effects. He requires medical attention, but the rest of the cartel die within a few seconds of each other and very cleanly.]]
* Played with on ''Series/{{Copper}}''. A police sergeant fails to recognize that the dead man has been poisoned because he decides to loot the man's belongings before examining the body. The sergeant even eats the cake that the dead man has not finished eating. The police detective who takes over the case quickly realizes that the dead man and the dead sergeant were poisoned by arsenic in the cake which they failed to taste because the cake was so sweet. If the sergeant bothered to turn the body over, he would have seen the vomit and the nasty state the victim's face was in.
* Subverted once on ''Series/{{Dallas}}''. A murdered victim was poisoned, and they died just when a trope LightsOffSomebodyDies happened... Must have been Perfect Poison. However, when the murderer was confessing to their crime, they said [[SubvertedTrope the lights off had been actually a coincidence]] and that the victim had had a poison inside them long before that.
* Averted in ''Series/{{Merlin}}'' when Merlin reluctantly poisons Morgana in order to break a spell that's been placed over Camelot. After he tricks her into drinking from a flask of water containing hemlock, it takes a while for her to feel the effects, and is a very slow and painful process once she starts dying.
* ''Series/{{Castle}}'' came incredibly close, albeit thanks to some special (but not rare) circumstances. A popular talk-show host named Bobby Mann was found dead of a suspected heart attack. However, Castle, who was just on his show and had Mann whisper in his ear that he thought his life was in danger, suspects murder. Two tox screens came back clear, but at Castle's insistence, they dig further, and find the truth: Bobby Mann was taking a very powerful medication for depression. The medicine reacts fatally with anything fermented. Knowing this, they realize the cranberry juice he was drinking was spiked with (fermented) balsamic vinegar, almost undetectable under the circumstances.
[[/folder]]

[[folder:Radio]]
* An old-time radio "Five Minute Mystery" titled [[http://www.otr.net/r/fmin/73.ram The Radium Murder Case]] tells of a murder exposed because, according to the investigator, the poison used would instantly knock out the victim upon contact with the tongue. In this case, the poisoning was openly stated but the perpetrator attempted to claim the poisoning as a suicide.
[[/folder]]

[[folder:Tabletop Games]]
* Realistic use of poison in most tabletop systems is extremely rare. This is mostly due to how roleplaying systems work -- poisoning someone over weeks or months is usually hard to make work mechanically, and usually won't be on the list of how PlayerCharacters [[WhenAllYouHaveIsAHammer off their opponents]].
* ''DungeonsAndDragons'' has a selection of poisons that deal a random amount of ability damage to one and only one ability score over two 'doses'. These damage doses happen exactly one minute apart regardless of the type of poison used. Terms such as dosage, dilution or long-term exposure never enter into it. Poison-users *are* in danger of poisoning themselves during application, however.
** ''Pathfinder'', being the SpiritualSuccessor to the above version of D&D, has updated the poison rules in response to this trope. Poisons can now have a various onset time anywhere between six seconds and a day, and some poisons can last indefinitely. One particular poison can kill someone (by Constitution drain) over an arbitrarily long period of time.
* Averted in ''{{Exalted}}''; the poison rules are designed around inflicting only one die of damage per time interval (which are generally in the hours), and can only inflict a limited amount of damage per dose. Multiple doses just extend how long the poison can last, while still only inflicting one die per interval. The most dangerous poison in the game (made from the concentrated hatred of [[EldritchAbomination demon gods]] and tremendously rare and expensive) would still take about seven seconds to kill most people (and would be rather obvious about it).
* In the RPG for LegendOfTheFiveRings, the Scorpion Clan (the underhand clan) sourcebook noted that while such poisons exist in universe, their oponents have gotten good enough to detect such compounds, which would point back to them. The book lists about 25 'natural' compounds that characters could use instead, few of which are fast, but all can be effective over time, and details are given for each. At the end of the section, it reveals the real names of all but 2 of them, being based on real world natural poisons.
[[/folder]]

[[folder:Theatre]]
* Creator/{{Shakespeare}} was in love with this trope. It seems like half his tragedies involve somebody getting poisoned with "the deadliest poison known to man".
** ''Theatre/{{Hamlet}}'': is particularly striking.
*** Laertes returns from abroad to find that his father had been murdered. Fortunately, he just so happens to have purchased a phial of Super Poison that he's going to use for the old "dueling with poisoned swords" trick. I guess that poison was available at souvenir stands all over France, next to the T-shirts and shotglasses.
---->'''Laertes:''' "I bought an unction of a mountebank, so mortal that, but dip a knife in it, where it draws blood no cataplasm so rare, collected from all samples that have virtue under the moon, can save the thing from death that is but scratched withal." Act IV, Scene VII.
*** The ghost of King Hamlet also goes into lavish detail about his own death by poisoning -- a poison that was dripped into his ''ear'' while he slept, and resulted in the most agonizing death throes, as well as hideous sores popping out all over his body.
** Surprisingly common Super Poison also appears in ''Theatre/RomeoAndJuliet''. Although as that poisoning was voluntary it probably wouldn't have mattered if it had had a distinctive smell or taste.
[[/folder]]

[[folder:Video Games]]
* ''Franchise/AceAttorney'': In the third case of ''Trials and Tribulations'', as well as the fourth case of ''Apollo Justice'', the victim dies from cyanide poisoning and from a (possibly) fictional poison, respectively, but in both cases the killer was more interested in having the person dead than hiding the method from the police (as far as ''what'' killed him, at least). As a result, the victim did not have a swift silent death, but instead gave full display of the poisons' physical reactions for all to witness, and the police have no trouble in figuring out what killed the victim.
* In ''{{Achaea}}'', a large number of poisons are available and widely used in combat. Most only cause [[HitPoints hit point damage]] or a [[StandardStatusEffects status effect]], but Voyria is invariably lethal...At least it should be, if it didn't take a full thirty seconds to do its work, during which the player [[{{Anvilicious}} receives SIX warning messages describing unmistakeable symptoms]] (mild fever, nose bleeding, bloody vomit, heavy breathing) and has only to take a sip of MagicAntidote to instantly save himself. As everyone carries antidote with them, the only practical way to kill someone with Voyria is to prevent the victim from drinking or injecting medicine.
* Averted in ''VideoGame/{{Hitman}}: Blood Money'': one of Agent 47's primary weapons is a syringe that can be used to inject targets at the jugular or to poison food. For efficiency's sake, instead of using a single poison, a mixture of chemicals is used: sodium pentothol, pancuronium bromide and potassium chloride. Since this is the exact combination of chemicals used in lethal injection executions, the victim dies quickly and noiselessly.
** Which only kinda makes sense. In lethal injections they use multiple [=IVs=] so the poisons don't mix beforehand and undergo a process called precipitation. A fancy way of saying they get all waxy and won't go in. And it can still take two hours for the victim to die. It would work better to just use one of the first two (the more fast acting drugs) and strangle the person after they pass out.
** Probably the reason that 47 carries around a reel of piano wire. However, ''Blood Money's'' use of poison makes more sense than the previous game, ''Contracts'': in several levels, you're forced to look for poisons in the surrounding area and dose people's food or drink with it, and weedkiller or rat poison aren't exactly painless or quiet.
*** It should be noted the the poison in Blood Money ''isn't'' undetectable; kills with poison count as regular kills rather than accidents.
** In Silent Assassin, one of the levels has as its target the son of a wealthy and powerful Japanese criminal. One way of achieving the kill is to sneak into the kitchen where a fugu dish is being prepared, and reintroduce the highly toxic liver to the dish. However, the toxin in the game works considerably faster than in real life.
* In ''FinalFantasyTactics'' [[spoiler:Dycedarg]] slowly poisoned his father over many years, which the rest of the family mistook for an illness.
* ''VideoGame/DragonQuestVII'' has the whole debacle in Verdham where [[{{Yandere}} Kaya]] is slowly poisoning her husband. The poison she uses is a powder which she keeps in a vial around her neck; her husband is convinced it's his ''medicine'', and you have to get the bottle away from her and its contents tested to prove otherwise.
* ''VideoGame/DragonAgeOrigins'' has a whole skill based around the creation of poisons and toxins to coat weapons with. These work instantly, though they generally have effects other than instant death (slows the target, does damage over time, paralyzes or stuns for a few seconds, etc.). Only Quiet Death can instantly kill, and even then it only has about a 5% success rate.
** The same goes for VideoGame/TheElderScrollsIVOblivion. There are also instantly fatal poisoned apples you can sneak into people's inventory, if they don't have any other food in there, they will eat the apples eventually and die.
*** Actually, the poisoned apples are not quiiite perfect; they only cause a permanent damage health effect of 10 per second. If you have a high enough health regen, you can survive, though it'll make the game much harder as you can't go to sleep again (can't sleep while being hurt). Cue the game ending instantly if you're forced to go to sleep, as your health regen drops to zero while sleeping as well.
* In an ending cut from JadeEmpire, Sky dies from drinking poisoned wine.
* In ''VisualNovel/{{Cinders}}'', Cinders can choose to kill her stepmother Carmosa with a poison that's stated to produce no noticeable ill effects in its victim until they suddenly drop dead of a seeming heart attack a couple of hours later. Its unusual effects ''could'' be handwaved as the result of it being crafted by a fairy or witch with access to magical powers, though. Plus, Cinders's poisoning attempt can fail spectacularly if Carmosa doesn't trust her and has the breakfast Cinders serves her tested for poison, which indicates that the poison's "perfect" qualities don't include untraceability.
* [[VideoGame/OneThousandAndOneSpikes 1001 Spikes]] explains the dart traps' quality of being able to kill instantly is because of them being poisoned. The Scorpions also qualify, because a single sting from them is immediately fatal.
[[/folder]]

[[folder:Webcomics]]
* ''MinionsAtWork'': [[http://www.minionsatwork.com/2009/02/minions-151-hard-to-swallow.html An early retirement plan with a fresh, minty after-taste!]]
* In the ComicBook/ChickTract "Party Girl", a man who drinks a poisoned drink dies in less than four minutes.
[[/folder]]

[[folder:Web Original]]
* On their wiki, the [[ProtectorsOfThePlotContinuum PPC]] refers to this as "Ye Olde Poisonous Poison."
[[/folder]]

[[folder:Real Life]]
* The assassination of [[http://en.wikipedia.org/wiki/Alexander_Litvinenko Alexander Litvinenko]], a prominent critic of then-president of Russia UsefulNotes/VladimirPutin, was "someone's" ''attempt'' at using a PerfectPoison which backfired spectacularly. Litvinenko was killed when someone sprinkled polonium-210 into his tea cup. Polonium-210 has many advantages: it can be carried safely in a vial of water through airport security without detection, is hard to detect in the human body when ingested, and while death is certain the initial symptoms don't immediately suggest poison, giving time for the poisoner to make a clean getaway. However they made one big mistake: they thought it was undetectable. Unlike most radioactive substances, Polonium-210 does not emit gamma rays, only alpha particles which cannot penetrate even a sheet of paper, thus being invisible to normal radiation detectors (and requiring it to be physically ingested to work as a poison). But the real kicker is while the technology to detect Polonium-210 didn't exist in Russia, it ''does'' in the West. Oops. Furthermore, whoever did the actual poisoning seemingly didn't realize how much Polonium-210 can contaminate. Simply uncapping the vial is enough to leave detectable amounts. These two things combined made Litvinenko's murder one of the most unsubtle in history, with investigators simply following the trail of radioactivity back to the murderer's hotel room.
* Genghis Khan's father is believed to have been killed by drinking poisoned milk during a meal with rival Tatars.
* The [[http://en.wikipedia.org/wiki/Richard_Kuklinski Ice Man]] said that he would kill people by putting large amounts of cyanide in drinks, spilling it on them, and walking away.
* [[http://en.wikipedia.org/wiki/Karen_Wetterhahn Karen Wetterhahn]] died after exposure to a tiny drop of dimethyl mercury on her gloved hand. However, the death was long and drawn out. (It was also horrifying to watch with all the thrashing and stuff; however, doctors said she likely wasn't in pain - her brain was well beyond the point of transmitting the likes of pain signals.) [[CaptainObvious And it wasn't untraceable either.]] Weaponizing it would be tough: While a cheap supermarket squirt gun full of the stuff would ensure the deaths of targets better than a rocket launcher, we're talking something ''so'' toxic that if you ''know what it smells like,'' that means you've most likely taken in enough of it that YouAreAlreadyDead.
** To clarify long and drawn out, she had the accident 8/14/96 and began showing symptoms in December of 1996. Three weeks after showing symptoms she slipped into a vegatative state alternating with periods of extreme agitation (the thrashing described above). She did not die until 6/8/97 when she was removed from life support.
* The rumors spread about Lucrezia Borgia by her family's enemies often included a reference to a poison she made called "la cantarella." Even if the Borgias ''did'' have people poisoned, this particular substance was alleged to be ''such'' a perfect poison that it could not in fact have been real (according to some versions of the story, the poison could be fine-tuned to kill the victim [[ExactTimeToFailure a specific preset time]] after ingestion).
* The real-life poisons abrin and ricin are both very deadly, and can easily be manufactured from common ornamental plants, making the origin of the posion difficult to trace. In the assassination of [[http://en.wikipedia.org/wiki/Georgi_Markov Georgi Markov]], identifying the organisation that was likely responsible (the Bulgarian Secret Police) was not done by tracing the ricin, but by investigating the capsule used to deliver the poison - a matching pellet had been recovered in the case of Vladimir Kostov, another Bulgarian defector who was attacked ten days before Markov's murder, although in his case the pellet appeared to have been damaged before it entered his body and did not retain enough ricin inside it to cause his death. Neither poison kills as quickly as the trope demands, but they're about as close as real life gets.
* Subversion: [[DeadlyGas Nerve gas]] when coming in liquid form kills in concentrations as small as a droplet for a roomful of air, and in this form is both transparent and odorless. However, it causes a death so horrible, painful [[ArsonMurderAndJaywalking and noisy]] as it's plain obvious what did it and there isn't a great detective effort to find out how it came - the range of suspects able to manufacture it it's pretty limited.
* A form of poison which is hard to trace to a suspect is [[BoringButPractical an excess of nicotine]] (injected in a dose much larger than usually lethal) in one of the victim's cigarettes. By the moment the victim drops dead, the said cigarette is already consumed, and autopsy reveals [[CaptainObvious only that he or she had a lot of nicotine in the body]]. It's very unreliable for an assassin who does not have permanent access to the victim's personal belongings and therefore it has hardly been used.
** Although a lethal dose of nicotine is usually a blatant giveaway of the foul play, unless the toxicity screen test is provided several days after death.
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