In video games with wide open worlds built on [[{{Backtracking}} revisiting the same locations over and over]], there are certain places that you can only enter once and never again. Sometimes this is because the place no longer exists thanks to being a DoomedHometown or a CollapsingLair. Sometimes it's because the plot keeps you out of it. Whatever the reason, these are places that can never be returned to.

The items inside the dungeon are frequently PermanentlyMissableContent and there are often times that you can only fill up your MonsterCompendium by grinding there.

'''Note:''' In order to qualify a game must be generally be open to {{backtracking}} and not just have a linear advancement through it. So the 1950s areas in ''{{Videogame/Portal 2}}'', for example, don't qualify here.


[[folder:Action Game]]
* In the first Xbox ''VideoGame/NinjaGaiden'', you can't go back to the Ninja fortress of chapter 1 nor in chapter 3's airship since it crashes.
* In addition to the obligatory CollapsingLair at the end of each game, the ''Franchise/ResidentEvil'' franchise has a number of destroyable locations that occur mid-game, such as the Hospital in ''VideoGame/ResidentEvil3Nemesis'', the part of Rockfort Island in ''VideoGame/ResidentEvilCodeVeronica'' where Claire starts out (destroyed shortly before her escape), and the train in ''VideoGame/ResidentEvil0''. The only exception thus far is the very first game and its remake, where the entire mansion and its outlying grounds are fully available to explore right up until you confront the final boss.[[note]]If we want to be picky, there is one room that is permanently closed off to Jill if you don't disarm the ceiling trap first.[[/note]]

[[folder:Action Adventure]]
* ''Franchise/TheLegendOfZelda'':
** ''VideoGame/ZeldaIITheAdventureOfLink'' provides an example with the Palaces that become Mountain squares on the overworld map after you beat them, but only after you both defeat the boss ''and'' collect the required item. The only things that can truly be [[PermanentlyMissableContent lost]] are some ExperiencePoint bonuses.
** In ''VideoGame/TheLegendOfZeldaALinkToThePast'', Hyrule Castle and its tower are permanently locked after defeating [[DiscOneFinalBoss Agahnim]] and entering the DarkWorld for the first time.
** ''VideoGame/TheLegendOfZeldaPhantomHourglass'' has the fourth dungeon, the Ghost Ship. It has a DevelopersForesight moment: if you leave without taking its Heart Container, the only item in the dungeon relevant to OneHundredPercentCompletion, it is sent to you via mail to {{avert|edTrope}} PermanentlyMissableContent.
** ''VideoGame/TheLegendOfZeldaSkywardSword'' has the final dungeon, the Sky Keep, which disappears once you [[spoiler:grab all of the Triforce Pieces]]. It has no Heart Pieces.
** ''VideoGame/TheLegendOfZeldaBreathOfTheWild'' has the Divine Beasts that, unlike the shrines, can't be visited after clearing them. Similar to ''Phantom Hourglass'', the Heart Containers found within are placed just outside them should you not pick them up before finishing the dungeon.
* In ''VideoGame/CaveStory'', Waterway is accessible only from an area whose entrance shuts permanently after a certain point. Depending on which story-path you take, ''the entire Labyrinth'' may become inaccessible.
* The insides of Demon Whale in ''VideoGame/{{Alundra 2}}'', which becomes unavailable after the thing turns back into a normal whale.
* ''VideoGame/{{Okami}}'' has the Moon Cave dungeon that cannot be accessed again once your defeat Orochi and leave it. There is also Oni Island, the miniature sections of the Imperial Palace, the Sea Dragon's body and [[spoiler: Past Kamiki]]. This is generally not frustrating since these areas only contain VendorTrash, but no important secret item -- with one exception to the spoilered area, which has a dog to feed. If you overlook this on your one visit to that area, you cannot get 100% Animal Tome completion.
* ''VideoGame/{{Okamiden}}'', the sequel to ''Okami'', is not so forgiving. It has the Five-Story Pagoda, the Moon Cave (again), the Underground Ruins, and the Ice Cavern, all of these contain unique items that are needed for HundredPercentCompletion.

[[folder:Eastern RPG]]
* ''VideoGame/{{Kingdom Hearts}}'' has Oogie's Manor in [[WesternAnimation/TheNightmareBeforeChristmas Halloween Town]]. [[spoiler:After defeating Oogie Boogie, he [[OneWingedAngel merges with his manor]] for another fight.]] Thus the manor is destroyed afterwards, as well as all its treasure--including a Red Trinity Mark that, if missed, [[PermanentlyMissableContent can't be recorded in the journal]]. The UpdatedRerelease moved that Trinity Mark to fix the issue.
* The ''Franchise/FinalFantasy'' series has plenty of these.
** ''VideoGame/FinalFantasyII'' has Emperor Palamecia's cyclone castle, which dissipates once he's defeated. Unfortunately, the cyclone also wiped half the towns off the world map before that, so here it's not just dungeons that get the worst of this trope. The towns are still visible on the map, but they are completely wrecked and cannot be entered.
** ''VideoGame/FinalFantasyIII'' has a floating Hyne Castle, which after finishing gets planted into a forest you're not allowed to get back to.
** ''VideoGame/FinalFantasyIV'' has the Tower of Zot, which [[CollapsingLair collapses once finished with]], as well as the Giant of Bab-il, and the Tower of Bab-il's two parts. Unlike the first two, the Tower of Bab-il actually remains on the world map--it's simply closed off.
** This happens in quite a few dungeons in ''VideoGame/FinalFantasyV'', such as Karnak Castle, the Lonka Ruins, the Barrier Tower, Exdeath's Castle, Fork Tower and others are destroyed or otherwise disappear.
** In ''VideoGame/FinalFantasyVI'' there's the Imperial Camp, Phantom Train, Magitek Research Facility, Sealed Cave, Floating Continent, and Cyan's Soul. There's also Kefka's tower, but only half of it.
** ''VideoGame/FinalFantasyVII'' has several locations that can only be visited once to name of. Sectors 1 and 5 reactors, Shinra Headquarters (won't be revisited again until the raid late in disc 2, and can't be revisited after that), Cave of the Gi, Corel Prison, Temple of the Ancients, Gaea's Cliff (and by extension the Whirlwind Maze), Underwater Reactor, and Midgar sector 8 during the raid.
** In ''VideoGame/FinalFantasyVIII'', there's Dollet Communications Tower, Galbadia D-District Prison, Missile Base, Galbadia Garden (during the attack), Great Salt Lake and Lunatic Pandora (only visited twice) leading to almost all locations inaccessible due to Time Compression. Not to mention the Laguna dream sequences.
** ''VideoGame/FinalFantasyIX'': Evil Forest, the Ice Cavern, Cleyra, Fossil Roo, and all of Terra (including Pandaemonium).
** ''VideoGame/FinalFantasyX'' has Home [[spoiler:which is destroyed immediately after leaving]], the Bevelle temple and the Via Purifico (which are blocked off).
** ''VideoGame/FinalFantasyXII'' has several, and in an uncharacteristic act of kindness, the programmers indirectly tell you which ones by giving you a prompt about not being able to leave them until you finish them when you try to save in them:
*** Nalbina fortress which is only there in the prelude due to it being destroyed.
*** Rabanastre Palace during the heist.
*** Nalbina Dungeons which is only accessible during your escape.
*** Several airship dungeons including the Leviathan and Shiva.
*** Draklor Laboratory in Archades.
* In both ''VideoGame/MOTHER1'' and ''VideoGame/EarthBound'', [[WackyLand Magicant]] vanishes. In the first game, Magicant can be revisited prior to completing a particular subquest; in the latter, it's a true One Time Dungeon with a few special items that are {{permanently missable|Content}}. There's also [[DarkWorld Moonside]] in ''[=EarthBound=]'', which [[spoiler:is just an illusion created by the Evil Mani Mani, and disappears when it is defeated]].
* ''VideoGame/MOTHER3'' uses a Chapter system, but most dungeons and areas in the game can be revisited in at least one later chapter (although the enemy types and layout will change with the plot). The major exceptions are the Attic Dungeon in Chapter 4, which becomes inaccessible once the Chapter ends with its completion, and the Thunder Tower, which is only accessible in Chapter 5 because the story at that point involves infiltrating and destroying it.
* The S.S. Anne in ''VideoGame/PokemonRedAndBlue''. After you heal the captain and he gives you the Cut [=HM=], the ship sails away, never to return. This leads to a few items there, including [=TM=]s, being [[PermanentlyMissableContent no longer obtainable]] if you didn't get them.
* In ''VideoGame/PokemonRubyAndSapphire'', the Team Magma/Team Aqua Hideout becomes inaccessible after beating Tate & Liza, which unfortunately makes the '''Master Ball''' [[PermanentlyMissableContent unobtainable]] if you don't get it before then. Thankfully, this doesn't happen in ''Emerald'' or the remakes.
* The Distortion World in ''[[VideoGame/PokemonDiamondAndPearl Pokémon Platinum]]''. The initial, plot-relevant area is one-time, anyway; you ''can'' enter it again later, though it's a different section of it.
* N's Castle in ''VideoGame/PokemonBlackAndWhite'' is destroyed and cannot be revisited. It can be in the [[VideoGame/PokemonBlack2AndWhite2 sequel]], though, as it is a BonusDungeon there.
* ''VideoGame/PokemonXAndY'' has the Team Flare Secret HQ, which is destroyed after clearing it. Fortunately, there's nothing there that you can miss out on.
* [[spoiler:Ultra Space]] in ''VideoGame/PokemonSunAndMoon''.
* The dungeons you explore in the future and The Nightmare in ''VideoGame/PokemonMysteryDungeonExplorers''
* Subverted to a degree in ''VideoGame/PokemonMysteryDungeonGatesToInfinity''. While the Glacier Palace and the Magnagate dungeons used to reach it can't be visited again through normal methods, it's possible to temporarily be warped into them for a few floors while exploring specific dungeons in the post-game.
* Showdown Mountain in ''VideoGame/PokemonSuperMysteryDungeon'' is only available once during a mandatory main quest, and isn't accessible afterwards.
* In ''VideoGame/ChronoTrigger'':
** The Black Tyrano fortress in 65,000,000 B.C. is destroyed when Lavos crashes into it. Mt. Woe in 12,000 B.C. is no longer accessible after the chain breaks and it falls into the sea. The Ocean Palace in 12,000 B.C. is no longer accessible after [[spoiler:Lavos awakens, destroying it and the Kingdom of Zeal]]. Also the Black Bird [[spoiler:as the heroes accidentally shoot it down after recovering the Wings of Time and finding that Dalton not only installed weapons but altered the controls while failing to label the buttons.]]
** [[spoiler:The Black Omen]] is also a possibility, depending on [[spoiler: which time period you finish it in. Completing it in the earliest time period (12,000 B.C.) prevents you from finishing it in the other two (600 A.D. and 1,000 A.D.) Going from the most recent time period to the oldest allows you to complete it 3 times total.]]
* In ''VideoGame/BreathOfFireI'', Nanai and the dungeon beneath it are destroyed after you leave. Neither Mogu nor Mote's dream dungeons can be re-entered once you complete them. The Goddess' Tower is also destroyed [[spoiler:after Jade releases the Goddess]].
* In ''VideoGame/BreathOfFireII'', a few locations become unrevisitable:
** The well beneath Capitan, as it floods after beating the boss. A few items can be missed, but furthermore, there are several trapped and possessed villagers (some of whom can potentially be chosen as carpenters to build Township later on) who can be missed for good if you don't go back for them.
** The vast majority of Mt. Fubi, as a rockslide destroys it after you beat the bosses (though a shortcut gets created as a result).
** HighFort can only be done once, as the fortress undergoes extensive damage following the boss fight there, and becomes completely inaccessible following Sten's arc.
** The levels that take place "inside" someone or something - the interior of Grandpa the Whale is inaccessible after you wake him up; Gandaroof's mind is only available until you defeat Aruhamel/Alzheimer; and the Queen of Tunlan's body is only available until she loses all her excess weight.
** Gandaroof's mind even has its own example-within-an-example: The initial village you visit, populated by elderly men? [[spoiler:Once you visit the town of Gandaroof's youth, one child there will remark that there's no town there, but a tower. Returning to the town of elderly men will reveal it to be the actual dungeon of the area.]]
** The trial/catacombs area of Wyndia is unavailable after Nina completes her trial there.
** The Grand Church is only available to visit once. [[spoiler:It collapses after you defeat the boss and either kill or free Ganer.]] Similarly, the toilet dungeon you escape through on your initial visit can only be done once.
* ''Franchise/SuperMarioBros'':
** ''[[VideoGame/MarioAndLuigiSuperstarSaga Mario & Luigi: Superstar Saga]]'' has the ''entire beginning of the game''; specifically, Mario's house, Peach's Castle (where you fight Bowser), Toadtown Square, the Koopa Cruiser, and the small bit in Stardust Fields before the Border Jump minigame. There's also the caves beneath the Chucklehuck trees, the Guffahwa Ruins, the S.S. Chuckola, and the repaired Koopa Cruiser who all are visited at one point and who all become unavailable for repeat visits after completion.
** ''VideoGame/MarioAndLuigiPartnersInTime'' has the Shroob Mothership, visited once after Thwomp Volcano and inaccessible as a dungeon afterwards.
** ''VideoGame/MarioAndLuigiPaperJam'' has an odd example. When Bowser Castle [[spoiler: takes flight and becomes [[TheVeryDefinitelyFinalDungeon Neo Bowser Castle]], the game treats it as a completely different dungeon, but the structure remains almost the same, with the sky replacing the earlier lava pits.]] So, while you can't revisit Bowser Castle, it could be said that [[spoiler:Neo Bowser Castle makes up for it.]]
* ''All story dungeons'' in ''VideoGame/HyperdimensionNeptunia''.
* Twice in ''VideoGame/{{Xenoblade}}''. First, a good chunk of the Ether Mines in Colony 6 becomes unavailable after the boss has been defeated; and well after that, it ups the ante by locking away [[spoiler:the entire freaking Mechonis, i.e. the other half of the game world, after it's been destroyed]].
* [[ShipLevel The beginner dungeon]] in ''VideoGame/{{Dubloon}}'' cannot be accessed after [[HopelessBossFight Bradley curb-stomps you]]. Thankfully there is nothing in this dungeon that can't be acquired anywhere else.
* In ''VideoGame/{{Ys}} IV''(both versions), the raising of the Ancient City causes certain dungeons to be destroyed or rendered inaccessable. After the city of Kefin reappears in ''V'', the desert town is buried by a sandstorm, and the dungeon under Xandria collapses [[CollapsingLair while you're escaping from it]]. In ''VI'', the Romun Fleet is destroyed by Galba-Roa after you're finished there, and Zemeth Sanctum also is destroyed by the Ark's revival.
* The ''VideoGame/GoldenSun'' franchise has a few:
** In the first game, the very first dungeon, Sol Sanctum, becomes inaccessible after you've completed it.
** ''[[VideoGame/GoldenSunDarkDawn Dark Dawn]]'' has multiple [[PointOfNoReturn Points of No Return]], but two stand out for completely opposite reasons. The first one is the Clouds of Passaj, which come immediately after the second PointOfNoReturn and the only one where the game warns you ahead of time that there's no going back after this point. [[note]]Ironically, every area in between the first and second PointOfNoReturn actually ''does'' become accessible again after the final PointOfNoReturn and there's one sidequest that can only be completed by returning during this time, though it still counts as a Point of No Return because there's one Djinni that can only be obtained before this point.[[/note]] After getting through the Clouds, you can't reenter them. The game's fairly merciful, though, in that the only treasure chests in the area contain common items that can easily be bought in item shops. The second, far more insidious one is the Belinsk Ruins. There's nothing to indicate that once you have the band play Arangoa Prelude, you won't be allowed to leave Belinsk until you complete the Ruins and even less to indicate that once you do, you'll have to leave Belinsk by sea when you entered it by land, and furthermore that Arangoa Prelude was in fact the third [=PoNR=] and that leaving Belinsk after [[spoiler:the Grave Eclipse has started]] is the ''fifth'', since you also can't go back into the Ruins after you've beaten their boss. There are ''two'' special summons that are only available during this time, as well as one Djinni and some fairly nice items in the dungeon's chests.
* [[spoiler:The Lifehold Core]] is the only place in ''VideoGame/XenobladeChroniclesX'' that can only be played once; afterwards you can only hang around the outside parts.
* ''VideoGame/ShinMegamiTenseiIV''[='=]s Monochrome Forest is only explored once, then becomes unavailable after you leave it. However, the demons that appear there can later be encountered in the Central Breakwater area, but getting there requires a GlobalAirship that requires some optional mini-dungeons and a quest..
* ''VideoGame/{{Persona 4}}'' has the Hollow Forest, the bonus dungeon in [[UpdatedRerelease Golden]]. When your party discovers it, you're warned that it's rapidly disappearing, which means that you don't have long if you want to [[spoiler:save Marie]]. Once you get what you came for, the dungeon self-destructs and is no longer available.
* ''VideoGame/{{Persona 5}}'' features Palaces, dungeons that are based around the distorted desires of specific individuals. Once the treasure representing the owner's desire is stolen, the Palace [[NoOntologicalInertia ceases to exist]]; it is up to the player when exactly to steal the treasure and trigger the collapse of the palace, meaning any chests that were not opened before or on the last day are lost forever. Any Personae found in the Palace, however, can either be fused or found in [[RandomlyGeneratedLevels Mementos]].
* The Ultharian spaceship in ''VideoGame/CthulhuSavesTheWorld'' becomes inaccessible once you defeat its boss because it crashes into the planet. Not even a chance to revisit it in the form of a holodeck simulation which wouldn't be out of place in a silly game.
* Several areas in ''VideoGame/CosmicStarHeroine'' cannot be revisited, especially ones you visit before getting your own spaceship. Among them are the building from the opening mission, the jungle path to a lab on Rhomu (the lab itself can be revisited later), API headquarters, the UnderwaterBase on Araenu and the asteroid.

[[folder:Interactive Fiction]]
* ''VideoGame/{{Eamon}}'': the Beginner's Cave (on the game's Main Hall disk) is accessible only once. The game checks when the player tries to access it; only a true beginning character is allowed to enter, and a player who finishes the cave is no longer a beginner.
* ''VideoGame/TheHitchhikersGuideToTheGalaxy'': Completing one of the sublocations can close it off to further play, usually by an insta-kill that sends you back to the Heart of Gold.

* The dream areas in ''[[VideoGame/{{Two}} 2]]'' that are found in each zone (including the intro) by sleeping in a bed. Once you grab the HeartContainer and leave, the beds inside each dream will explode.
* In the vanilla edition of ''VideoGame/OriAndTheBlindForest'' all of the major dungeons, as well as the maze portion of the Misty Woods, are either destroyed or sealed off upon completion, but the Definitive Edition allows you to revisit them, and also removes the much-maligned PointOfNoReturn at the FinalDungeon entrance.

* Pre-Searing Ascalon in ''VideoGame/GuildWars'' invokes this via DoomedHometown. It's intended as a tutorial area to leave at around level 4 or so, but the area is so pretty and nostalgic that some players choose to stay there forever.
* In ''VideoGame/MapleStory'' once you leave Maple Island, you can't go back. That ship inexplicably only goes in one direction. The game blends this with GuideDangIt and PermanentlyMissableContent, because there is a special quest reward that will boost your HP recovery while resting that you can only get by sticking around.
* ''[[VideoGame/WorldOfWarcraft World of Warcraft: Cataclysm]]'' introduces several in the form of {{Doomed Hometown}}s for the Worgen and Goblin races. It is possible to return to Gilneas, although there is no longer anything there (and that means absolutely ''nothing'', no [=NPCs=] and no enemies, which arguably makes an already BleakLevel even [[NothingIsScarier creepier]]). However, Kazan and the Lost Isles are completely sealed off once you leave. Notably, this started with the Death Knight starting experience in Wrath of the Lich King. Mists of Pandaria continued this tradition with the Pandaran starting area, The Wandering Isle. The last time a starting zone was introduced that was contiguous with the main world was Burning Crusade.
* ''VideoGame/CityOfHeroes'' is generally very good when it comes to backtracking, as you can replay most story arcs and badge missions at will via the Flashback System. However, Praetorian Characters get hit by this trope ''hard''. The first three Praetorian zones can be revisited at any time, but the story arcs can ''never'' be replayed once you outlevel them. The Praetorian Alignment Badges and Temporary powers are [[PermanentlyMissableContent lost]] if you don't have them when you leave. This is due to an issue with the game's KarmaMeter.[[note]]Resistance and Loyalist characters are their own alignments, and certain contacts are only accessible if you have the corresponding alignment. As you can change your alignment multiple times throughout the storyline, being able to replay the arcs as a Hero or Villain would screw things up.[[/note]] Praetoria used to be a much more extreme example of a One Time Dungeon. When the zones were first released, leaving Praetoria at level 20 meant leaving it ''permanently''. There was no way back! Things have gotten much more relaxed now.

[[folder:Platform Game]]
* ''VideoGame/JakAndDaxter'':
** In ''VideoGame/JakIIRenegade'', the final level can't be returned to [[PlayableEpilogue after finishing the game]]. This causes 7 Precursor Orbs (the game's hidden collectables) to become [[PermanentlyMissableContent unobtainable]].
** Various locations in ''VideoGame/Jak3Wastelander'', including (but not limited to) the [[LethalLavaLand Great Volcano]], [[UndergroundLevel Catacombs]], [[EternalEngine KG War Factory]], and [[ItsAllUpstairsFromHere Metal Head Tower]].
* The [[NoobCave tutorial levels]] in ''VideoGame/RatchetAndClank'' games generally can't be revisited after completion. However, in some cases ([[spoiler:Veldin from ''VideoGame/RatchetAndClank2002'' and Aranos from ''VideoGame/RatchetAndClankGoingCommando'']]) an [[RemixedLevel altered version]] of the level appears later on, from which point it can be revisited. There's also the decommissioned Blarg ship in Nebula G34 from ''VideoGame/RatchetAndClank2002'' and the Leviathan in Zeldrin Starport from ''VideoGame/RatchetAndClankUpYourArsenal'', both of which explode upon completion.
* Every boss level in ''VideoGame/TinyToonAdventuresBustersHiddenTreasure'' cannot be revisited once completed. Justified in that upon playing through them, Buster rescues one of his BrainwashedAndCrazy friends from Dr. Gene Splicer's [[HypnoTrinket mind control helmets]], or in the case of the [[GhostShip haunted pirate shipwreck]] level, has already found and collected the titular "hidden treasure". These elements are important in keeping the game's story intact.
* ''VideoGame/SuperMarioWorld'': The Switch Palaces cannot be re-entered after beating them, even after the game is completed.
* The starting stage of ''VideoGame/SuperMarioLand2SixGoldenCoins'' can't be replayed after beating it. Also, the boss stages can't be replayed unless you get a GameOver and lose all the [[PlotCoupon Golden Coins]] you've collected.
* ''VideoGame/CrashBandicoot2CortexStrikesBack'': If you sit through the intro with Crash and Coco without skipping it, you can play an "intro stage" where Crash runs into the jungle to take something Coco needs; you'll find some breakable crates and Wumpa Fruits, but no important collectables, so this is entirely optional.
* ''VideoGame/MegaManZero 4'': you'll be unable to re-access the intro stage (takes place on moving trucks and then moves onto an enemy airship) and the "forced stage after defeating 4 main bosses" (takes place around Area Zero, in which you fight [[TheDragon Craft]] for the first time). The latter also has an enemy (Moloid) exclusive to that stage; the machine parts that they drop will contribute towards 100% completion, not to mention being the ingredient for some good enhancement upgrades, so you better make sure you get 2-3 parts of them before you finish the stage.
* ''Videogame/MegaManZX Advent'' has the intro stages for both characters, Grey[[note]]takes place in a part of an abandoned lab; late game stage will have you visit another part, as the bridge that connects the two parts are broken in the intro's boss fight[[/note]] and Ashe[[note]]takes place on an airship that crashes down in the end[[/note]]. Interestingly, in the world map for both characters, you can see where their intro stages were placed, but you get no option to go there.

[[folder:Western RPG]]
* ''Franchise/TheElderScrolls'':
** ''[[VideoGame/TheElderScrollsIVOblivion Oblivion]]'' has the Painted World area and a dream sequence that can't be returned to. Closing an Oblivion gate destroys that instance, although it's possible (and indeed likely) to find an identical map behind another gate, but completing the main quest line permanently closes all the gates, cutting off access to Oblivion entirely.
** ''[[VideoGame/TheElderScrollsVSkyrim Skyrim]]'':
*** Skuldafn, which the Dragonborn cannot reach after the first run through it because one needs to be able to fly to reach it, and the friendly dragon who let you ride him there won't do it again. [[GameplayAndStorySegregation You can't even return after you gain the ability to tame and ride dragons]] from the ''Dragonborn'' DLC.
*** ''Skyrim'' also has [[spoiler:[[WarriorHeaven Sovngarde]]]], which is only accessible through Skuldafn, and, by extension, cannot be returned to.
* In ''VideoGame/KnightsOfTheOldRepublic'', once you leave Davik's Estate upon acquiring [[CoolStarship Ebon Hawk]], you cannot return to it (or the rest of Taris of that matter) due to the Sith razing the planet. You also cannot return to the Leviathan after breaking out from it.
* In ''VideoGame/KnightsOfTheOldRepublicIITheSithLords'':
** Goto's Yacht cannot be revisited, as it is destroyed after you complete it. You also can't go back to Peragus (the beginning planet) for the same reason.
** The only time you get to explore the Telos Restoration sites is when you're searching for your stolen ship. You also cannot revisit Ludo Kresh's tomb once you're done.
** You only travel to Onderon twice (you instead get to revisit one of its moons, Dxun, at your leisure), but due to its political predicament it's [[RemixedLevel in a vastly different state on the return trip]].
* In ''VideoGame/{{Fallout 3}}'', completists would be advised to grab the collectible Energy Weapons bobblehead during the brief Raven Rock sequence, since once the door shuts behind you, [[PointOfNoReturn you're never getting back in there]].
** Same for Vault 101 and the Medicine bobblehead, although you get to revisit one final time in the "Trouble on the Homefront" sidequest.
** The Anchorage Reclamation simulation in the ''Operation Anchorage'' DLC, and the Mobile Base Crawler in ''Broken Steel'' are also only accessible once.
** You can go back to Mothership Zeta after completion, but only parts of it; most of the lower half of the ship, including the two optional areas, is locked after the "Among the Stars" quest, and once you teleport to the Death Ray Hub, the teleporter breaks, locking you out of the Weapons and Experimentation Labs.
** In ''Point Lookout'', the Calvert Mansion self-destructs at the end of the "Thought Control" quest.
* ''VideoGame/FalloutNewVegas'':
** The Dead Money DLC cannot be visited after it is completed , unlike the Old World Blues, Honest Hearts and Lonesome Road DLC. It's explained as the path being "hard to find"; the person who brought you there (while you were unconscious) even says that he occasionally has to sniff to find the trail again. So while you'll be able to go back to the Mojave, getting back to the Sierra Madre seems next to impossible.
** The ''Honest Hearts'' DLC zigzags this trope. You can go back to Zion once the main quest is over, but all of the [=NPCs=] are gone. So, the dungeon itself is still there, but the experience is gone.
* ''[[VideoGame/{{Diablo}} Diablo II]]'': The Cow Level can only be played once per difficulty level.
* The Ruins in ''VideoGame/{{Undertale}}'' is the only major area in the game that cannot be revisited after clearing it. The doorway leading to it will lock, and stay that way for the rest of a regular playthrough. Taking advantage of this, one midboss late into the game can be skipped by buying an item only available either at the Ruins, or right before said boss at a ridiculously high price. [[spoiler:The doors to the Ruins are re-opened after the final boss of the best ending, and the location can be explored again during the ending's epilogue]].
* In ''{{Fallout 4}}'', if siding with any faction other than the Institute, their underground base (as well as the CIT Ruins above it) will be destroyed in the final story mission, and if siding with either the Institute or the Railroad, the Brotherhood of Steel's airship will be destroyed in the penultimate quest.
* ''VideoGame/SouthParkTheStickOfTruth'' has actually many examples.
** The alien spaceship becomes inaccessible once it crashes at the end of the first night.
** The school can't be explored a third time after the human assault on the second night.
** The interiors of your house's walls becomes blocked with a wooden plank at the end of the second night.
** The abortion clinic doesn't allows the character to advance beyond the reception after the battle with [[spoiler: the giant Nazi zombie fetus]].
** [[spoiler: Clyde's Fortress]], TheVeryDefinitelyFinalDungeon, also disappears after the credits. Same for [[spoiler: Mr. Slave's Ass]].
* In ''VideoGame/MassEffect1'', while most side worlds can be freely revisited, Therum, Peak 15, [=ExoGeni=] building and Virmire all become inaccessible once you complete your mission in these locations. That's nothing compared to the sequel where even sidequest areas can be visited only once.
* In ''VideoGame/RavenswordShadowlands'', you cannot return to the titular [[TheVeryDefinitelyFinalDungeon Shadowlands]] after you are done with them.