[[quoteright:350:[[Franchise/{{Batman}} http://static.tvtropes.org/pmwiki/pub/images/notagain.jpg]]]]
[[caption-width-right:350:Strictly speaking this is supposed to be dramatic, but [[LikeYouWouldReallyDoIt you]] [[SuperDickery know]]...]]
->'''Red:''' We've got a complaint, sir. A guest found a pan-dimensional hellhound in their soup!\\
'''Monkey:''' Again?\\
--''WesternAnimation/LeagueOfSuperEvil''

%% One quote is enough, any new one should be put in the Quotes Subpage.

A simple comedy dialogue trick is to have something bizarre happen, and then have someone say "not again", implying it's happened before. The actual phrasing can vary. A slightly less funny version (unless done just right) is where it actually has happened before, on-screen, and the character is just [[ContinuityNod pointing that out]].

A variation is to have the character say something along the lines of "This is just like X all over again," where X is something typically ordinary, such as prom, or graduation.

See also HereWeGoAgain, and ThisIsGonnaSuck, which can be combined with it. Is often used in conjunction with the NoodleIncident (especially if what happened the last time hasn't been mentioned or seen before, particularly if the "This is just like X all over again" variation is used).

Related to DidntWeUseThisJokeAlready
----
!!Examples

[[foldercontrol]]

[[folder:Advertising]]
* Jared's second Dave/GPS commercial; naturally, Dave invokes this trope as he remembers what happened [[http://www.youtube.com/watch?v=a69eC7ldAcI last time]].
* In the second video in Game Fly's "Bad Game" commercial, a man who looks like Owen Wilson says "Not again..."
* The head guard in a [[http://www.youtube.com/watch?v=ctrUY4CWocY Captain Morgan rum]] commercial manages a nonverbal version of this, shaking his head and glaring with a look that's all too clear when he sees Captain Morgan breaking someone out of prison.
* A kid sister yelling "Mom, he's done it again!" was the {{punchline}} to two ads from [[TheNineties the 1990s]]:
** A famous [[SuperBowlSpecial Super Bowl]] spot for Pepsi about a boy on a beach who quickly finishes off a bottle of the cola with a straw, then [[VacuumMouth can't stop sucking]] for [[ThePowerOfCheese one more drop]] until the ensuing vacuum causes [[BodyHorror his entire body to crumple up and squeeze]] through the neck of the bottle so he's left trapped inside, much to the [[DisgustTropes disgust]] of his onlookers.
** An Airheads commercial wherein a boy's gobbling down a whole piece of the taffy [[CerealInducedSuperpowers turns him into its balloon mascot]] and rockets him through the roof. In this one the girl first warns him of what happened last time, as is evidenced by the other boarded-over holes in the ceiling.
[[/folder]]

[[folder:Anime & Manga]]
* In the beginning of ''Manga/ChronoCrusade'', Rosette wails, "Why does this sort of thing always happen to me?!" after her mission to exorcise a demon ends in her crashing a ship into the Statue of Liberty. The very next chapter confirms that this sort of disaster happens ''because of'' her all the time.
* Early in ''Manga/{{Cyborg 009}}'' when the cyborgs were painting their ship, 007 accidentally knocks down a bucket of paint on [[TheComicallySerious 008's]] head while arguing with 006. [[HilarityEnsues A noisy chase ensues]], which 004 comments laconically:
-->'''004:''' Not again.
* ''Anime/DragonBallZ''
** During the Buu Saga, after Piccolo and Gotenks discover the ruins of the Lookout, Piccolo states "the Lookout is destroyed... again." Those who've watched the Anime will most likely think back to the Garlic Jr. Saga, which is the only other time that the Lookout was destroyed ([[NoodleIncident onscreen, anyway]]).
** Similarly, when Krillin, when trying to come up with an excuse for Gohan's whereabouts to Chi-Chi, considered saying "Gohan's been kidnapped again!" The only other onscreen times he was kidnapped was during the events of the film ''Dead Zone'', and when Raditz kidnapped him at the start of ''DBZ''.
* Boss from ''Anime/MazingerZ'' has his made-of-scraps-and-junk HumongousMecha (Boss Borot) wrecked nearly each episode, so often he utters one sentence along the lines of "Why it is always me?", or "Not again!". He even lampshades it in one ''Anime/UFORoboGrendizer'' manga chapter: He is going to fight ''Anime/GreatMazinger'' (long story), and he is knocked down with a mere backhand. Then he says "The most painful thing is I knew what this would happen."
* In the ''Anime/GreatMazinger vs Manga/GetterRobo'' features, Boss Borot's arms gets eaten by a {{Robeast}}. Later his HumongousMecha gets rebuilt, he fights that {{Robeast}} again... And his robot's limb gets eaten again. Boss yells: "What? AGAIN?"
[[/folder]]

[[folder:Comic Books]]
* SilverAge Franchise/{{Superman}} once flew through Hell, causing Hitler to look up and shout "Oh no, not again!" Golden Age Superman had defeated Hitler in one of Action Comics's first issues.
* ''Negation'' had the CatchPhrase BOHICA (Bend Over -- Here It Comes Again).
* ''Franchise/{{Batman}}''
** The image at JokerImmunity is from The Batman Adventures comic ''Mad Love''. It has the last two words of this trope. (The panel before showed Batman hitting the Joker out of a train and him saying: ''"Oh, no..."'')
** The Trope Image comes from ''Batman'' issue 246 where a villain kidnaps Robin and then keeps "killing" dummies of him in various ways all over the place.
* ''ComicBook/{{Transmetropolitan}}'': A particularly deranged-looking Spider hails/hijacks a cab.
-->'''Cabbie:''' Please don't kill me and eat me! I couldn't bear to be killed and eaten again!
* The DonRosa Duck comic, ''The Quest for Kalevala'', the sea-monster Iku-Turso wreaks havoc on Helsinki. An citizen calmly comments:
-->"Wow, that is the second biggest frog I have ever seen."
[[/folder]]

[[folder:Comic Strips]]
* In an early ''ComicStrip/FoxTrot'' arc, Andy becomes quite paranoid that her husband Roger is having an affair, when he calls to tell her he'll be home late again. As Andy continues to think of ways he could be lying to her about what he's ''really'' doing, Roger counters her questions with substantive answers. He even puts the phone up to his desk chair and says "Listen -- you know how my chair squeaks?" "Sounds like bedsprings", Andy replies, and Roger yells for a coworker named Fred to "get over here and talk to [his] wife", to which the ''coworker'' groans "Not again..."
* ''ComicStrip/TheFarSide'':
** A [[TheStoner hippie]] stops at a house to ask for directions; upon noticing that the person he's speaking with is an [[MixAndMatchCritters elephant-bird-giraffe-man]], the hippie says, "Oh, wow, déjà vu."
** In another one, a group of soldiers at a frontier fort are being attacked by assailants using suction-tipped arrows. One of them groans, "Cripes, not ''these'' Indians again!"
** [[MorallyAmbiguousDucktorate A duck]] and a scientist both wash up on a deserted island. The duck says, "So, Professor Jenkins!... My old nemesis!... We meet again, but ''this'' time, the advantage is mine!"
* In a ''ComicStrip/{{Garfield}}'' strip, Garfield is complaining about how there's only reruns on TV, and leftovers in the fridge. Then Jon runs by, screaming about how the plumbing has backed up, and pirahnas are spawning in the toilet. Garfield's reaction? "Again?!"
** In one strip around Christmas, Garfield comments that it still doesn't feel like Christmas - and then Jon comes in tangled up in Christmas lights with the tree strapped to his back:
--> '''Jon:''' I did it again.
--> '''Garfield:''' NOW I feel Christmasy.
[[/folder]]

[[folder:Fan Works]]
* In ''Theatre/AVeryPotterMusical'', when Voldemort and Malfoy are making an Unbreakable Vow (i.e. a spit-shake):
-->'''Malfoy:''' ''(before Voldemort can get out of the shake)'' And you have to be my slave for a whole day starting now!\\
'''Voldemort:''' You little shit! You got me, oh this is so embarassing! That's the ''second'' time that's happened!
* In the ''WebVideo/PotterPuppetPals'' episode "The Vortex", we have this exchange:
-->'''Hermione:''' Professor Dumbledore! Ron's trapped in an alternate dimension!\\
'''Dumbledore:''' Oh no, not again!
* Yet more ''Literature/HarryPotter'' silliness: ''FanFic/OhGodNotAgain'' is a breezy PeggySue-parody [[FanFic fic]] in which 23-year-old Harry gets to relive his entire childhood fortuitously having [[GenreSavvy done it all before]].
* Used to lampshade the increasingly frequent instances of "darkness enfolding him" in ''FanFic/ToyHammer''.
-->"Darkness enfolded me. Again."
* Said by Fakir in ''WebVideo/PrincessTutuAbridged'': "Did I just get taken out by a ninety pound ballerina? Damn, not again."
* ''FanFic/TakamachiNanohaOf2814'' has a spectacular example that is ''entirely in line with canon''.
-->"I am going to die a virgin," [[Franchise/SailorMoon Tuxedo Kamen]] said, then added conscientiously, "[[DeathIsCheap Again]]."
* Negi Springfield in ''Fanfic/EqualAndOppositeAttraction'' quotes this verbatim before passing out when he discovers that, yet again, he is teaching mages in his class.
* Sasaki says this almost word for word (she drops the "no") in chapter 54 of ''FanFic/KyonBigDamnHero''. [[spoiler:It's the third time she's been captured by the Sumiyoshi-rengo.]]
* Said by Sam in ''[[FanFic/FacingTheFutureSeries Strength In Numbers]]'' when she learns that Danny had a two-hour eating binge ''[[NoodleIncident again]]''.
* This is Apollo's reaction in ''TurnaboutSubstitution'' when Phoenix {{Rick Roll}}s him over the phone.
* From ''Monster of the Week'''s take on the ''[[Series/TheXFiles X-Files]]'' episode "Demons"
-->'''Mulder:''' (over the phone) Hey, Scully. I just woke up covered in blood in Rhode Island.
-->'''Scully:''' Again?
[[/folder]]

[[folder:Films -- Animation]]
* From ''Film/TheAdventuresOfTintin'':
-->'''Tintin:''' Mrs. Finch! A man's been shot on our doorstep!\\
'''Mrs. Finch:''' Not again.
* In ''Anime/LittleNemoAdventuresInSlumberland'', during the song about training Nemo to be a prince, the horse that Nemo tries riding on flips him off his seat and onto the fat dancing lady, who catches him, and he says, "Not again!", indicating that she has tried to make him dance before.
** Earlier in the film, when Nemo is first supposed to meet the king, he finds the throne to be empty, causing Professor Genius to say this exact phrase.
* The RunningGag in ''RockinWithJudyJetson'' where Felonia Funk goes into a bounce-off-the-walls rage if she even hears the word "music," forcing her lieutenant Gruff to douse her with water. The first time it occurs in the movie, he grumbles, "Here we go again."
* At the beginning of ''ComicBook/{{Asterix}} Conquers America'', this is the Roman senate's reaction to learning that another platoon of legionaries has gotten thumped by Asterix's village ''again''.
[[/folder]]

[[folder:Films -- Live-Action]]
* Used twice in ''Film/MouseHunt''. First, when the Mayor faints after swallowing half a cockroach, his wife yelps, "Oh, no! Not again!" Later, when Lars and Ernie go to the animal shelter and ask for a vicious cat, Mory tells them he has the perfect one: "I had all but given up hope of anyone wanting him. We were about to gas him again."
* John Hurt's character gets out this line during his cameo in ''Film/{{Spaceballs}}'' when [[spoiler:a miniature Alien bursts out of his chest -- which is, of course, an ActorAllusion to his role in ''Film/{{Alien}}''.]]
* Along similar lines, in ''Film/AttackOfTheClones'' when Anakin dives off the side of a speeder in the middle of high-speed, ''flying'' traffic, all Obi-Wan can come up with is, "I hate it when he does that."
** Later in the same film Anakin's lightsaber is destroyed (leaving him weaponless). When he realizes it, he laments "Again? Obi-Wan's gonna kill me."
* In ''Film/MaryPoppins'', about fifty chimney sweepers roll out of the Banks family's fireplace and [[CrowdSong start dancing around singing]]. And the first thing the cook says when she sees them is, "They're at it again!"
* After a hotel-roof shootout in ''Film/LastActionHero'', culminating in a crane causing a helicopter to crash, Jack Slater (portrayed by Ah-nold), asks his kid sidekick to bring the car around. Upon being informed that the helicopter landed on it, he replies, "I hate it when that happens."
* ''Film/DieHard 2'': "How can the same shit happen to the same guy twice?"
* In ''Film/{{Beerfest}}'', Jay Chandrasekhar's character wakes up naked in the middle of a field after a night of heavy drinking. Lying next to him is a dead deer with blood around its neck, Jay's character with blood all over his mouth. "Ohhh, not again!"
* Rick O'Connell in ''[[Film/TheMummyTrilogy The Mummy Returns]]'' upon seeing the Soldier Mummies back in action. "Oh no, not these guys again!"
* In ''Film/ScottPilgrimVsTheWorld'', Scott's sister Stacey finds out Wallace has seduced her new boyfriend behind her back. Her response? "Wallace? ''AGAIN?!''"
* In ''Film/AirplaneIITheSequel'': "Ted, I have the strangest feeling we've been through this exact same thing before."
* At the very end of the ''Series/DoctorWho'' television movie the Doctor is just settling down to relax in his TARDIS when his gramophone starts to skip, causing it to repeat the word "time" over and over again, [[BookEnds just like it did at the start of the movie]]. The last line is the Doctor's despairing "Oh no... ''not again!''"
* The "This is just like X all over again" variation occurs in ''Film/TheAvengers''. Black Widow comments that the fight they're currently in is "[[NoodleIncident Budapest]] all over again." Hawkeye [[DeadpanSnarker snarks]], "You and I remember Budapest very differently."
* In ''Film/JayAndSilentBobStrikeBack'', the studio guard interrupts the filming of the ShowWithinAShow ''Good Will Hunting 2: Hunting Season'' with the announcement that they have "a 10-07 on their hands." A 10-07 (two unauthorized persons on the studio lot) is not to be confused with a 10-82 (disappearing a dead hooker from Ben Affleck's trailer). But the guard's announcement does cause the following exchange:
-->'''Matt Damon:''' (exasperated) "Oh ''Jesus!'' Again Ben?"
-->'''Ben Affleck:''' (cocky) "No, ''bullshit!'' Because I wasn't ''with'' a hooker today, ha-HA!"
** Later in the same movie, Mark Hamill has this trope as his response when [[[[Franchise/StarWars his hand gets chopped off]].
* In ''Film/SherlockHolmes'', Mrs. Hudson spots her tenants' dog keeled over on the floor. Watson's follow-up response implies this is a somewhat regular occurrence.
-->'''Mrs. Hudson:''' "Oh, look, he's killed the dog. ''Again.''"
-->'''Watson:''' ''(to Holmes)'' "What have you done to Gladstone now?"
* In the soundtrack to ''Film/JohnCarter'', the music that plays when John is fighting the [[KillerGorilla White Apes]] is called "The Second Biggest Apes I've Seen This Month". Considering that the White Apes are about 5 metres tall...
[[/folder]]

[[folder:Literature]]
* ''Literature/TheHitchhikersGuideToTheGalaxy'', where two missiles in flight are turned into a whale and a bowl of petunias. The whale has an entire internal monologue, but the bowl of petunias just thinks "Oh no, not again." One of the sequels actually explains why it thinks this, turning it into a BrickJoke.
* A subtle example from ''Literature/{{Discworld}}'': It's demonstrated in ''Discworld/CarpeJugulum'' that in the kingdom of Lancre, a child's legal name is whatever the priest calls them at christening. One of the characters later mentions a former king named "My God He's Heavy ''the First''".
** One of the "flashbacks" in ''Discworld/{{Thud}}'' reads "On this day in 1802, the painter Methodia Rascal woke up in the night because the sounds of warfare were coming from a drawer in his bedside table. Again."
* In Lev Grossman's ''[[Literature/TheMagicians The Magician's Land]]'', a Pegasus says this exact line when hearing that [[spoiler:the land of Fillory is dying]].
[[/folder]]

[[folder:Live-Action TV]]
* ''Series/{{The Office|UK}}'': "He's put my stapler in the jelly again!"
* ''Series/StargateAtlantis''
** When Dr. Weir's mind is taken over by an alien, everyone reacts with shock. Except [=McKay=], who just whines, "not again". We'd seen another character taken over by aliens a few episodes before. Before that, [=McKay=] himself had had a woman's mind inhabit his brain and take over his body.
** [=McKay=] also says this when he's trapped in a sinking ship for the second time.
* In ''Series/BuffyTheVampireSlayer'', a warning of the impending apocalypse is met with a CollectiveGroan of "Again?" by the Scoobies. We've seen several near-apocalypses before.
* ''Series/ThirtyRock''
** In an episode, Liz, trying to figure out [[ICantBelieveAGuyLikeYouWouldNoticeMe why a hot man wants to date her]], tells him at one point that "If you're a gay guy looking for [[TheBeard a beard]], I don't do that anymore!"
** In another episode, she asks Jenna, "What's going on? Why are being so happy and nice? Are you soaking your tampons in vodka again?"
* ''Series/GetSmart''
** A more specific version is one of the best-known running gags from Maxwell Smart.
-->'''Max:''' The old Professor-Peter-Peckinpah-all-purpose-anti-personnel-Peckinpah-pocket-pistol-under-the-toupee trick. That's the second time I've fallen for it this month.
** He also notes that some absurdly large items are "the second biggest __ I've ever seen."
* ''Series/{{Smallville}}'':
-->'''Chloe:''' Clark has amnesia.\\
'''Lois:''' Again?
* One episode of ''Series/{{NCIS}}'' had a suspect, upon walking into his living room to find the team pointing guns at him, say "Not this again! Bloody hell!" Interestingly enough, he also was rather surprised to find they're cops.
* Queen Machina in ''Series/PowerRangersZeo'' when Mondo is struck down by the Super Zeo Megazord.
* Tenaya on ''Series/PowerRangersRPM'', the second time Dr. K grabs her [[MusicalAssassin violin]].
* The ''Series/MadTV'' sketch "[[http://www.youtube.com/watch?v=dymb0SvHCnY Gump Fiction]]" had PhilLaMarr reprise his role from ''Film/PulpFiction''. As a nod to the meta, he shouted out, "Not again!".
* On ''Series/PressYourLuck'', one of the {{Whammy}} animations featured one attempting to blow up the contestant's winnings with a PlungerDetonator, only to have it blow up in his face instead; this is followed by "Not again..."
* On ''Series/TheBigBangTheory'', when Sheldon sees Leonard and Penny kissing after they've broken up, he sighs "Oh, [[Series/BattlestarGalacticaClassic friggity-frack]], not this again."
* Played with on ''Series/ParksAndRecreation'':
-->'''Leslie:''' Some guy handcuffed himself to a pipe in my office because we wouldn't put a copy of ''Literature/{{Twilight}}'' in the time capsule.\\
'''Ben:''' ''(sarcastic)'' Dammit, again?
* A ''Series/SabrinaTheTeenageWitch'' episode had her aunts warning Sabrina about wish magic in which if a witch desires something or someone enough that their magic can make them spontaneously appear. The aunts demonstrate this by saying the name of singer Music/RandyTravis three times and he promptly appears in their kitchen. Travis looks around and instead of freaking out he sighs and says “Hello Hilda, hello Zelda and you must be Sabrina. I’ve heard a lot about you.”
** Reinforced when he leaves the house: ''If you need me, you know where to find me... you always do''
* In a late season 6 episode, ''Series/HowIMetYourMother'' went meta when Ted responded to something Barney said with him having the feeling that in fact, they collectively learn the opposite lesson at least once every year for a while now.
* ''Series/NedsDeclassifiedSchoolSurvivalGuide'': In the Guide to Money, one of Cookie's several failed attempts involves a failed ventriloquism act. Moze sees the poster, and she invokes this trope.
-->'''Moze:''' Oh, no. Not Baxter Bear!
* ''Series/DoctorWho''
** The trope appears in the episode "[[Recap/DoctorWhoS32E5TheRebelFlesh The Rebel Flesh]]":
-->'''The Doctor:''' I have to get to that cockerel before all hell breaks loose! ''({{beat}})'' [[ARareSentence I never thought I'd get to say that again.]]
** And this gem, from "Night Terrors":
-->'''[[TheyKilledKenny Rory]]:''' Oh great, we're dead. ''[[LampshadeHanging Again]]''.
** In the end, Amy died twice and Rory died ''ten'' times (and only three times off-screen). Rory deserves particular mention for dying of old age ''twice'' without use of any rapid-aging [[AppliedPhlebotinum phlebotinum]].
* When ''Series/{{Leverage}}'''s Eliot uncharacteristically starts making Sophie tea, Parker asks her if she's hypnotized Eliot "again".
* Two separate occasions with Joy in ''Series/MyNameIsEarl'':
-->'''Joy:''' Darnell, get me a rag! Somebody kicked me in the face in the bathroom again!\\\
'''Joy:''' Darnell, call the police! Exterminator sprayed me in the face with rat poison again!
* This brief exchange in ''Series/{{House}}'', reinforcing the title character's "everybody lies" belief.
-->'''Random Patient:''' I'm still a virgin.\\
'''House:''' ''(flatly)'' You're pregnant.\\
'''Patient''' ''(exasperatedly resigned)'' Again?
* ''Series/{{Scrubs}}'' as the exact same scene as part of a montage that eventually breaks Turk. It's played for laughs. Kinda.
* Hilariously used by Creator/GeorgeTakei in ''Series/{{Psych}}''. Throughout the episode, there are references to a horrible experience he had at a convention in San Antonio. Shawn and Gus (who have tricked Takei into thinking they're assistants he doesn't remember hiring) end up solving their case on stage just as Takei is about to go on, with Shawn pretending to use Gus' "magic head" to channel his psychic abilities. Off to the side, Takei angrily remarks that this is the same thing that happened in San Antonio.
* In an episode of ''FatherTed'', Ted is showing Bishop Brennan a number of security measures to stop Father Jack from sleepwalking, one of which is a rope snare:
-->'''Ted:''' I'd like to see him chew through that. (Bishop moves out of earshot) ''Again''.
* A RunningGag on ''TheCosbyShow'' involving Sondra and Elvin's tumultuous relationship before they ultimately got married.
--> '''Huxtable #1:''' Sondra broke up with Elvin.
---> '''Huxtable #2:''' Again??
[[/folder]]

[[folder:Music]]
* From David Lang's "Are You Experienced? I. On Being Hit on the Head": "What happened? That felt like... a blow to my head! That's twice this week!"
* ''Music/LinkinPark'' lampshades this trope in "Bleed it Out" - a song about the frustration of writing lyrics:
-->''Now here we go for the hundredth time...''
[[/folder]]

[[folder:Puppet Shows]]
* In ''Film/TheGreatMuppetCaper'' when Beauregard drives his cab into the Happiness Hotel and then into the kitchen [[note]] which invokes FridgeLogic when you remember the "Happiness Hotel" song flat out said the place had no kitchen[[/note]]:
-->'''Pops:''' Well, it looks like steering wheel soufflé for dinner.\\
'''Janice:''' Again?
* From ''Series/{{Dinosaurs}}'', when Robby is sent home with a letter from his teacher.
-->'''Fran:''' "Dear Mr. and Mrs. Sinclair, your son Robert was expelled from school today for rejecting all known belief and threatening to obliterate the foundations of social order!"\\
'''Earl:''' AGAIN!? What is it with you?
[[/folder]]

[[folder:Radio]]
* In the ''Franchise/SherlockHolmes'' novel ''The Sign of Four'', Holmes has been forgoing sleep out of frustration with the case, and Mrs. Hudson remarks to Watson, "I hope he's not going to be ill, sir." The radio adaptation with Clive Merrison changed this line to "I hope he's not going to be ill again," highlighting Holmes's [[ForgetsToEat habitual self-neglect]].
[[/folder]]

[[folder:Toys]]
* Finishing Martian Attack in ''Pinball/AttackFromMars'' and starting it again gives you this soundbite from the Martians:
--> "Not you again? OHHHHH!"
[[/folder]]

[[folder:Video Games]]
* In ''VideoGame/{{Halo 3}}'', if you stick a Grunt with a plasma grenade with the "I Would Have Been Your Daddy" Skull turned on, you will occasionally hear them utter "Not again!" before they explode.
* ''VideoGame/BaldursGate 2'' has a moment like this has a moment that is somewhere between SugarWiki/{{Heartwarming Moment|s}} and {{Narm}}; if you pursue a romance with (widowed) Jaheira you will at one point be ambushed by bandits, and you have the option of taking an arrow for her... which causes the somewhat narmy reaction of "Blast you filthy bogslimes! Not again!"
* In the ''VideoGame/WarioWare'' series, Ashley's theme song includes the lyrics "Pantalones giganticus! / Oh no, not again!" to conclude a presumed spellcasting attempt by the young witch. What actually happened is left as an exercise to the audience.
* At the beginning of the ''VideoGame/TeamFortress2'' video "Meet the Spy", the huge wall-o'-signs that light up in combinations to form messages like "ALERT" -- "RED SPY" -- "IN THE BASE" has one that just says "AGAIN", meant to be used at the end of any message. (This board was later turned into an actual in-game prop in the map Double Cross.)
* The boat captain from ''VideoGame/GodOfWar'', every time Kratos pwns him.
* ''Franchise/SuperMarioBros''
** In ''VideoGame/PaperMario'', one of the [=NPCs=] in the beginning of the game complains that Bowser captured Peach ''again'', [[ExcusePlot since that pretty much is the plot of every Mario game]].
** In [[VideoGame/PaperMarioTheThousandYearDoor the sequel]], Peach is being held captive by the X-Nauts and laments "I can't believe I've been kidnapped! Again!"
* ''VideoGame/MonkeyIsland''
** Guybrush Threepwood has a tendency to say "that's the second-[superlative] [noun] I've ever seen!" Played with in ''VideoGame/EscapeFromMonkeyIsland'', where Guybrush observes a giant sea shell and says "That's the second-biggest... no, wait, that ''is'' the biggest conch shell I've ever seen!"
** In ''VideoGame/TalesOfMonkeyIsland Chapter 5: Rise of the Pirate God'', Guybrush will say, "Not again," and get dispossessed if he keeps trying to escape from jail using the secret passageway without the Spirit Gum.
** Also, during the BattleInTheRain in Chapter 1, when Guybrush botches up the recipe for the Cutlass of Kaflu due to [=LeChuck=]'s meddling by breaking the bottle of root beer, Elaine sighs and says, "And now we're going to die. Again. Heh. Wonderful."
* One of the quotes that a ''VideoGame/{{Gruntz}}'' may say when it dies.
* In ''Ultimate VideoGame/MarvelVsCapcom3'', if Frank West wins a match, zombies will show up and chase him down. Sometimes, he'll angrily complain, "Again? Why do you guys always go for me?"
* In ''VideoGame/KingsQuestVIHeirTodayGoneTomorrow'', Alexander says "Not again!" [[spoiler:when he gets caught by the druids on his second trip to the Isle of the Mists. This "Not again!" quote marks the second time that he's been captured (the first time was by the Winged Ones).]]
* Raiden's [[MajorInjuryUnderreaction incredibly deadpan reaction to losing another arm]] in ''VideoGame/MetalGearRisingRevengeance'' is a simple "Shit. Not again.".
* Malvolio Portius of ''VideoGame/WildStar'' has a great distaste for the Chua. The "Dirty Little Secrets" video shows why.
--> '''Chua:''' (puts bomb on Malvolio's goblet)
--> '''Malvolio:''' (brings goblet back to his face, sees bomb) Oh, not again...
* ''VideoGame/FinalFantasyXIII'' has one funny case. Early in the game, Hope finds a Pulse Dreadnought mech that can be piloted, and uses it in the Vile Peaks to allow Lightning and him to quickly bust through some enemies and barriers. Flash Forward to Chapter 11, while the party is exploring a mine on Gran Pulse, and have to come up with a way to hitch a ride on the Fal'Cie Atomos. Hope, once again manages to find another pilotable Dreadnought mech, and struggles to control it just like before, with the plan to use it to stop Atomos, leading to an exasperated Lightning to note "[[DeadpanSnarker It's the Vile Peaks all over again]]".
* During a section of ''VideoGame/SaintsRowIV'' that parodies ''VideoGame/MetalGearSolid'', one of the guards you kill will shout "not again!" Considering it's a simulation, it's quite possible that the guard ''had'' been killed before.
* In ''VideoGame/{{Gruntz}}'', it's one of the quotes said by a grunt when he dies.
[[/folder]]

[[folder:Web Animation]]
* In ''[[http://www.albinoblacksheep.com/flash/sitcom391 Sitcom #391]]'' by ryoshenron:
-->'''Bobby:''' I just stole the neighbor lady's laundry off of her clothes line, so we can frolick around in my house in her panties... again.\\
'''Tommy:''' That sounds like a smashing idea, Bobby.
* In one ''WebAnimation/HomestarRunner'' short, Strong Bad's office computer explodes, reducing it to ashes. Strong Bad declares it the ''worst'' computer explosion he's ever seen. One of his computers ''had'', in fact, exploded before then. Twice.
* ''WebVideo/UltraFastPony''. In "Hippocratic Oafs", Twilight's only reason for saving Ponyville from the giant bear is, "So, Celestia says she doesn't want to lose another entire town to bear attacks this week, so consider yourselves lucky!" In "One Joke to Rule Them All", Rainbow Dash's pet parasprites turn violent, and her reaction is, "My new family's [[HilariouslyAbusiveChildhood trying to kill me again]]!"
[[/folder]]

[[folder:Web Comics]]
* In a ''Heart of It All'' comic, a spinoff of ''Webcomic/{{Concession}}'', the Author Avatar exclaims "Not again!" upon being bodily carried away by an FBI agent as he's [[ItMakesSenseInContext slowly turning into a Martian.]]
* ''Webcomic/GirlGenius'': "[[http://www.girlgeniusonline.com/comic.php?date=20090717 A bucket? Again?]]"
** Made funnier by one of the better DeadpanSnarker lines by Agatha. "Yeeeeeess. I suspected as much."
* ''Webcomic/{{xkcd}}'': The AltText for [[http://xkcd.com/700 this comic]] is "Why do all my attempts at science end with me being punched by Batman?"
* ''Webcomic/TheOrderOfTheStick''
** Roy; yes, it's the second time this day they've misplaced a party member.
-->'''Roy:''' [[http://www.giantitp.com/comics/oots0099.html Damnit! Not again!]]
** [[DistressedDamsel Celia]] gets her turn later:
-->'''Celia:''' [[http://www.giantitp.com/comics/oots0615.html Darn it! Not again!]]
** Darth Vaarsuvius being frustrated for the second time from using his incredible powers.
-->'''Vaarsuvius:''' [++[[http://www.giantitp.com/comics/oots0646.html NOT AGAIN!]]++]
** Durkon joins in:
-->'''Durkon:''' [[http://www.giantitp.com/comics/oots0732.html Och, not AGAIN!]]
** And in the prequel book ''On the Origin of [=PCs=]'', when Sir François the paladin can't stand any longer his herald's stupidity and ditch him... guess what's the reaction.
-->'''Elan:''' Awww, not again.
* ''Webcomic/YetAnotherFantasyGamerComic''
** [[http://yafgc.net/?id=200 Strip #200]]:
-->'''Nike:''' It's your goblin friend, Gren! She's been captured by pirates!\\
'''Bob:''' Oh no... not again!
** [[http://yafgc.net/?id=2357 Strip #2357]]:
-->'''Bob:''' Your majesty, I wish to complain about your husband. He's chained himself to my girlfriend.\\
'''Drow Queen:''' Again?
* ''Webcomic/QuestionableContent''
** Not in these exact words, [[http://questionablecontent.net./view.php?comic=1402 but the implication is there]].
** And much later, the gang is playing a drinking game where they sit in a circle and say something nice about the person to their left (Faye describes it as "Group therapy with booze")
-->'''Steve:''' ''(hugging Martin)'' I love you man! I love you!\\
'''Martin:''' ''Dude, we have talked about this.''
** Also not in the exact words, [[http://questionablecontent.net./view.php?comic=2481 but Martin clearly implies that he has done this before]].
* ''Webcomic/{{Drowtales}}'': Even though the line isn't spoke aloud, fans agree that this is what was going through Quain'tana's head when [[spoiler:Syphile]] [[http://www.drowtales.com/mainarchive.php?order=chapters&id=1011 jumped out to shout a challenge]]. It's all in the expression.
* ''Webcomic/{{Bobwhite}}'': [[http://www.bobwhitecomics.com/?webcomic_post=20081017 Ivy leaves some fish in the care of her roommate Marlene.]] Seconds later, several of the fish are dead. Marlene says, "I wish I could say this is the fastest a friend's pet has died in my care. I really do."
* ''Webcomic/{{Sinfest}}''
** Slick, upon... [[http://www.sinfest.net/view.php?date=2009-07-22 falling]] into FireAndBrimstoneHell.
** When [[AcceptableReligiousTargets Seymour]] walks into the [[AttractiveBentGender Trans Zone]] while under the influence of Cupid's arrow, his reaction is a lot more mellow than the first time.
--> '''Seymour :''' [[http://www.sinfest.net/view.php?date=2012-10-12 Oh ... This again]].
* ''Webcomic/ThePigsEar'': [[http://www.pigsearonline.com/2009/07/02/strange-leavings/ "That is the third strangest thing I've ever seen in a pub toilet."]] The mind boggles at what the first two might be.
* ''Webcomic/BugMartini'': [[http://www.bugmartini.com/comic/anti-amish-alliteration/ Bug really is a bona fide bungler of barn raisings]]:
-->'''Bug:''' I accidentally nailed a board to my face.\\
'''Amish:''' Again?
* ''Blog/SliceOfLife'': When Mr. Cake freaks out about the prospect of Pound having to get flying lessons, Pumpkin responds "Mom! Dad's broken again!"
[[/folder]]

[[folder:Web Original]]
* In the review of [[http://thatguywiththeglasses.com/videolinks/team-nchick/vampire-reviews/36165-count-chocula Count Chocula cereal]], [[WebVideo/TheNostalgiaChick Maven]] summons WebVideo/TheNostalgiaCritic by saying "Nostalgia" three times. When she says it backwards, he turns into a puppet, to which he sighs and says "Not again."
** After spending most of [[WebVideo/TheSpoonyExperiment Spooning with Spoony]] traumatized and mute, in TheStinger Critic wails that "It's prom night all over again!"
** Played for FridgeHorror in ''WebVideo/ToBoldlyFlee'', when Lame R. Prick makes the mistake of calling [[TheGameHeroes 8-Bit Mickey]] short one too many times. Mickey quivers with rage and tells Prick YouWouldntLikeMeWhenImAngry and Prick ignores him. Cut to Mickey walking away covered in blood holding a severed hand, and WebVideo/TheCinemaSnob saying "someone must've called Mickey short again".
[[/folder]]

[[folder:Western Animation]]
* ''WesternAnimation/TheSimpsons''
** Barney Gumble often says this. Once after mistaking a life-sized, woman-shaped bottle of maple syrup for a woman, knocking "her" over and flooding the store.
** Another time, after drinking an "all-syrup Squishee" and [[WhatDidIDoLastNight waking up in a Greek cargo ship wearing a sailor's outfit]].
** In another episode, Homer organizes half the population of Springfield into forming the world's largest human pyramid. However, thanks to [[HanlonsRazor human stupidity]], the pyramid collapses and instead turns into a giant ball of people that rolls down the streets of Springfield. As he runs for his life from the ball, [[TheChewToy Hans Moleman]] cries out, "Not again!"
** When virtually all of Springfield has joined the [[ChurchOfHappyology Movementarians]], Rev. Lovejoy is seen spreading gasoline on the church floor.
-->'''Rev. Lovejoy:''' I never thought I'd have to do ''this'' again.
** "Can't we have one meeting that doesn't end with us digging up a corpse?"
** "Can't we just call in David Bowie?" -- He's already done so much for this church.
** "Now, now dear. It's only until we have to pay off your father's desecration of a priceless artifact. ''(despondent sigh)'' I never thought I'd have to say ''that'' again."
* In ''WesternAnimation/TheVentureBrothers'' first episode "Dia Los Dangerous", Doctor Venture wakes up in a bathtub full of ice, with a missing kidney, and says, "Not again," then realizes this means he's missing both kidneys, causing him to calmly say, "This is serious."
** Another when Brock realizes the boys have been kidnapped right before a bomb goes off in his face.
--> '''Brock''': (With an OhCrap expression) Myra's back.
* In a reference to one of the original shorts that inspired ''WesternAnimation/SouthPark'':
-->'''Stan:''' Put the [[FrostyTheSnowman hat on the snowman]], Tweek.\\
'''Tweek:''' But what if it comes to life and tries to kill us?!\\
'''Stan:''' C'mon, when has that EVER happened, except for that one time?
* ''WesternAnimation/{{SpongeBob SquarePants}}''
** In an early episode, Mr. Krabs' arms pop off while attempting to pull a dime out from a drain. Spongebob says the stock phrase exactly, implying that Mr. Krabs loses his arms on a regular basis. Even within the same episode Mr. Krabs lost his arms again, and it became a running gag that in a state of shock, disapproval or other emotional duress, he sometimes literally falls apart. There's also the repeated occurrence of Squidward accidentally swallowing his clarinet, but Spongebob only references it in a later episode when it grows from a simple gag to a plot-guiding calamity- he pulls the clarinet out of Squidward's throat, but its reed breaks off and remains stuck, requiring medical attention from Sandy to remove it.
** Mrs. Puff says this after briefly considering changing her name and moving to another town after giving Spongebob a boating license before he's qualified to drive.
** When he and Squidward think [=SpongeBob=] ate a bomb disguised as a pie, Mr. Krabs said he's seen this before. When questioned on it, he simply replies he'd seen it ''11 times''. Then Squidward, in guilt, calls the doctor for help, the doctor apparently tells him the exact same thing as Mr. Krabs.
* ''WesternAnimation/CodeMonkeys'': "God''damn'' it, that's the second time I've eaten shit this week!"
* In ''WesternAnimation/TheGrimAdventuresOfBillyAndMandy'' ChristmasSpecial, the mall they visit for Christmas is ultimately burned to the ground (Billy's fault), causing Grim to wonder why every time he takes them to the mall it burns to the ground. Billy blames the economy.
* From ''WesternAnimation/TheCritic'': "Oh good ''heavens''!! Can't ''one single dinner'' go by without our having to discuss your rotting corpse?!"
* The classic bumpers from ''WesternAnimation/RockyAndBullwinkle'':
-->'''Rocky:''' And now...\\
'''Bullwinkle:''' Hey, Rocky! Watch me pull a rabbit out of my hat!\\
'''Rocky:''' Again?!
* ''WesternAnimation/PhineasAndFerbTheMovieAcrossThe2ndDimension'':
-->'''Dr. Doofenshmirtz:''' {{If I had a nickel}} for every time I was doomed by a puppet, I'd have two nickels. Which, well, it isn't a lot, but [[LampshadeHanging it's weird that it happened twice, right?]]
* ''WesternAnimation/{{Rugrats}}'': When Charlotte arrives at the office late, her relieved assistant Jonathan says, "I thought you'd been abducted by eco-terrorists again."
* ''WesternAnimation/MyLittlePonyFriendshipIsMagic''
** In the episode "The Cutie Mark Chronicles", the Cutie Mark Crusaders' attempt to earn their Cutie Marks via zipline fails and ends with them covered in tree sap and pine needles. Frustrated, Scootaloo gives the following statement:
-->'''Scootaloo:''' It's no use. No matter what we try, we always end up without our Cutie Marks... and surprisingly often, covered in tree sap.
** In the episode "A Friend in Deed", Pinkie says she accidentally put the confetti in the oven and the cake in the confetti cannon... again!
* In an episode of ''WesternAnimation/{{Wildfire}}'', the title horse agrees to be a wage in an effort to rescue a friend of his. To win, the heroes have to find out where a certain troll lives and what his name is. After they find the troll, he says they'd need six clues. Based on their experience trying to find the troll, Sara deduces his name and won. She then returns to the mortal realm, where her Native-American friend, Helen, learns her dream name but isn't allowed to tell anyone. Sara then asks for a clue and Helen says she'd need six. Sara then invokes the trope.
* ''WesternAnimation/{{Wakfu}}'', season 2 episode 4:
-->'''Evangelyne:''' Amalia and Ruel have gotten themselves turned into ghouls!\\
'''Sadlygrove:''' Again? Ruel will end up getting a taste for it...
* WesternAnimation/SamAndMaxFreelancePolice
-->'''Max:''' Curses. Foiled by a clip on tie. It's Prom Night all over again.
* From ''WesternAnimation/{{Animaniacs}}'' when the Warners meet Literature/SherlockHolmes and [[ItMakesSenseInContext need to borrow Watson for a scavenger hunt]]:
-->'''Yakko:''' This always happens. Every time we get our hands on a [[TheWatson fat chubby sidekick,]] whammo, he's kidnapped by a Scottish guy with a huge sombrero in a flying contraption!
* Happens to Shendu in the ''WesternAnimation/JackieChanAdventures'' episode: "Re-Enter the Dragon" when Uncle, Tohru, Captain Black and all of Section 13 used the same spell that Lo Pei originally used to turn Shendu back to stone and to sever him from his talisman power. Even attempting to disrupt the spell was met with failure.
* A variation, from ''WesternAnimation/{{Archer}}'':
-->'''Cyril:''' I'm so sorry I slammed you in the gut. Geez, that's how Houdini died!\\
'''Pam:''' Houdini died of AIDS!\\
'''Cyril:''' No! Why do you always say that?
* The classic ''WesternAnimation/LooneyTunes'' cartoon ''Rabbit Fire'':
-->'''Daffy:''' ''(to Elmer)'' What are you?\\
'''Elmer:''' I'm a hunter.\\
'''Daffy:''' And what season is it?\\
'''Elmer:''' Wabbit season.\\
'''Bugs:''' ''(points to Daffy)'' And if he were a rabbit, what would you do?\\
'''Daffy:''' Yeah, you're so doggone smart! If I were a rabbit, what ''would'' you do??\\
'''Elmer:''' Well, I'd... ''(aims at Daffy)''\\
'''Daffy:''' ''(weakly)'' Not again... ''(gets blasted)''
* Said word-by-word by WesternAnimation/{{Caillou}}'s father when Caillou climbs out of the bathtub again.
* In ''WesternAnimation/TheWeekenders'', [[DeadpanSnarker Tino]] suggests that an unresponsive Carver's brain will leak out of his ears unless someone plugs them. Lor says "I did it ''last'' time!"
* Done in ''WesternAnimation/TheBoondocks'' when a famed rapper named Gangstalicious was reported to have been shot on stage.
--> '''Huey and Riley''': Again?!\\
'''Sway''': (Exasperated) Again.
* ''WebAnimation/BravestWarriors'' "Dan Before Time", when Future Danny travels back to the moment Danny is about to use his time machine and destroys it to prevent him from creating a TemporalParadox or a TimeCrash.
-->'''Wallow:''' This happens every time you invent a time machine.
* Also brought up in ''WesternAnimation/KingOfTheHill.''
-->'''Dale:''' ''(Playing golf)'' Hey, if my balls lands on the back of a passing bird, which is then attacked by a larger bird who deposits it into the hole, is that still a hole in one? 'Cause that's how I'm gonna score it.
-->'''Hank:''' Dale, it already happened once. What're the odds of it happening a second time?
* A variant in ''Film/RecessSchoolsOut'', when T.J. frantically tries to tell his parents about [[ItMakesSenseInContext the terrorists building a giant laser beam in the cafeteria of Third Street School]], shortly after [[RunningIntoTheWindow accidentally running into the sliding glass door to his house]]. His mother doesn't believe him, thinking that the bump on the head rattled his brain. When he runs off to the garage to tell his father instead, he just rolls his eyes and asks, "Did you run into the sliding glass door again?"

[[/folder]]

[[folder:Real Life]]
* WebSite/TextsFromLastNight has this as its second most common trope ([[WhatDidIDoLastNight I'm sure you can guess the first.]]) [[http://textsfromlastnight.com/Text-Replies-5481.html This one]] is particularly nice:
-->'''#1:''' Banned from zoo.\\
'''#2:''' Again?
* QDB
** [[http://www.qdb.us/15920 This one]]. Comes with a side dish of {{Squick}}.
** There's [[http://www.qdb.us/303630 another one]] with less Squick and more TooDumbToLive.
* In one edition of ''[[Series/CountdownWithKeithOlbermann Countdown]]'', Keith Olbermann called out the TSA for detaining a high-ranking member of the British government who was ''working with the Department of Homeland Security'' because his name was the same as one on their watch list -- and it wasn't the first time it had happened to him.
-->"He's in the Cabinet! And we patted him down for weapons at Dulles Airport! AGAIN!!"
* In Creator/ImprovEverywhere's spontaneous musical ''[[http://improveverywhere.com/2009/11/05/i-love-lunch-the-musical/ I Love Lunch!]]'', the character "Jeff" begins by standing on a balcony expounding upon how much he loves lunch, and his friend below tells him, "Jeff...don't sing a song, man..." Later, in the middle of the song, he can be heard saying, "He does this every day..."
* Charles de Gaulle, leader of the [[LaResistance French resistance]] during UsefulNotes/WorldWarII and President of UsefulNotes/{{France}} after the war, was targeted by at least thirty assassination attempts during his presidency. He reportedly said "What? Again!?" during one such attempt.
* One episode of the docudrama series Untold Stories of the E.R. recounted an incident in which a heart attack patient had his bypass surgery delayed because they found a homemade sex toy in his rectum and found and decided it was not safe to operate until it was removed. When his wife found out, the emergency physician was surprised that her response was this trope. "I told you those things are dangerous!"
[[/folder]]

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