->''"What's wrong with policemen on television these days? They're always complete opposites. One's of them fat and poor, the other one's thin and posh. One of them's a woman, the other one's a Martian. One of them has four heads, one of them's ''allergic'' to heads."''
-->-- '''Inspector Fowler''', ''Series/TheThinBlueLine''

Mr Neat/Tidy/Law-Abiding/By-The-Book forced to work/live with Mr Messy/Slob/Zany/Risk-Taker/Plays-By-His-Own-Rules. Despite the name, they're usually not a romantic couple (though this depends on the show in question).

The couple [[BuddyCopShow might be]] [[TheyFightCrime cops]].

The original [[TropeNamer Odd Couple]] were ''Theatre/TheOddCouple,'' a SitCom based on a movie based on a play of the same title, about two divorcees, NeatFreak Felix Unger and his [[TrashOfTheTitans sloppy]] friend Oscar Madison, having to live together.

If the pair lives in a HighFantasy realm, a Hidden World of Awesome, or an Absurdist World of Awesome, you may be watching a PsychedelicComedyBromance.

See also: SaltAndPepper, PolarOppositeTwins, TomboyAndGirlyGirl, SensitiveGuyAndManlyMan, RedOniBlueOni, OppositesAttract, TwoGamersOnACouch, BadassAndChildDuo. Compare HeterosexualLifePartners. May be part of a WunzaPlot.

If it's not the two main characters, it's an OddFriendship.
----
!!Examples

[[foldercontrol]]

[[folder:Anime And Manga]]
* Two anime play on the ''RobotDetective'' motif (see Literature): ''ArmitageIII'' (Armitage is secretly a robot, Sylibus is an Earth transfer with anti-robot leanings) and ''{{Anime/Metropolis}}'' (Robot and Human detective, based on the book).
* It's implied that before Shinji Ikari's arrival in his class at school in ''Anime/NeonGenesisEvangelion'', that Kensuke Aida (nerd) and Touji Suzuhara (jock) were this.
* ''TenchiMuyo'' - The space-cop pair "Miho-Kiyo" -- BornLucky BrainlessBeauty Mihoshi and CosmicPlaything ByTheBookCop Kiyone. They're the same in whatever series they appear (though Kiyone does not appear in the first OVA series).
* ''{{Nana}}'' - Nana and Hachi, who is [[NamesTheSame also really named Nana]].
* ''FutariWaPrettyCure'' - Part of the premise; two unlikely partners are a sports-loving tomboy and a brainy class rep.
* ''Manga/{{Bleach}}'' has a whole lot of these.
** The Shinigami, most notably in the 13 squad divisions with many of its captain and lieutenant sets:
*** 1st Division: Subverted in the case of Captain Genryūsai Shigekuni Yamamoto and Lieutenant Chōjirō Sakisabe. Yamamoto enjoys Japanese culture but dislikes European, and holds Japanese tea sessions for his squad, while Chōjirō is obsessed with European culture and dislikes Japanese to the point of growing his own tea leaves. However, this is the only area in which they differ. They're very well matched aside from this.
*** 2nd Division: Captain Shaolin "Soifon" Fon (LesYay {{Tsundere}} IceQueen JerkassFacade) and Lieutenant Marechiyo Omaeda (DumbMuscle ButtMonkey {{Gonk}}).
*** 3rd Division: SmugSnake TricksterMentor Captain Gin Ichimaru and melancholic WarriorPoet Izuru Kira. [[spoiler: Averted with Rose and Kira who have bonded through their shared artistic natures.]]
*** 6th Division: Subverted with AloofBigBrother Captain Byakuya Kuchiki and HotBlooded Lieutenant Renji Abarai. [[AllThereIntheManual Clarified]] as being an in-universe belief that's not true in reality due to Byakuya being HotBlooded BeneathTheMask making the pair NotSoDifferent. However, a lot of characters don't know this.
*** 7th Division: Calm and collected Captain Sajin Komamura and HotBlooded Lieutenant Tetsuzaimon Iba
*** 8th Division: Captain Shunsui Kyōraku (BrilliantButLazy and TheDandy) and Lieutenant Nanao Ise (stiff and formal with a PrimAndProperBun to show it).
*** 10th Divison: Captain Tōshirō Hitsugaya (an extremely serious, focused {{Workaholic}} ChildProdigy) and Lieutenant Rangiku Matsumoto, who is easy-going, easily distracted and BrilliantButLazy, not to mention significantly older, taller, and bustier, subverting the usual image of the seasoned captain and the raw lieutenant.
*** 11th Division: Subverted with SociopathicHero Kenpachi Zaraki and RoseHairedSweetie Yachiru Kusajishi. Yachiru is as blood-thirsty as he is.
*** 12th Division: MadScientist Mayuri Kurotsuchi who will fly off the handle very easily and ExtremeDoormat Nemu Kurotsuchi who barely reacts to anything unless ordered to. [[MadScientist Mayuri]] [[ArtificialHuman created her]] [[MadScientistsBeautifulDaughter to be like that.]]
*** 13th Division: Ukitake is a tall, peaceful, calm individual who tries to negotiate conflict between friends and allies with smooth-talking, friendly soothing words. Rukia's short, HotBlooded, and prefers to either beat sense into friends and allies or passionately yell at them.
** In the "[[WholeEpisodeFlashback Turn Back The Pendulum]]'' arc, we have:
*** laid-back, easy-going Shinji Hirako and conniving EvilGenius, Sousuke Aizen.
*** Kensei Muguruma ([[HairTriggerTemper Temperamental]] JerkWithAHeartOfGold) and Mashiro Kuna (ManChild GeniusDitz).
*** Kisuke Urahara (NiceGuy) and Hiyori Sarugaki (BrattyHalfPint {{Jerkass}}).
** Even the ex-captain traitor ''trio'' qualifies: Kaname Tōsen is a mostly stoic BlindJustice KnightTemplar, Gin Ichimaru is an AxCrazy FauxAffablyEvil EnigmaticMinion, and Sōsuke Aizen is an AffablyEvil MagnificentBastard HeroKiller VillainSue. Enjoyable TeethClenchedTeamwork ensues.
* ''Manga/{{Naruto}}'' - Akatsuki offers two examples:
** Hidan (dedicated priest who despises the greedy) and Kakuzu (bounty hunter who covets money and despises religions). The only reason they haven't killed each other yet is they're both immortal.
** Sasori (strict artist who values the ageless quality of his puppets) and Deidara (relaxed artist who values the transient beauty of his explosions). Despite their constant arguing about art, they respect one another and work well together.
** Arguably, 'Odd Couple' applies to virtually everyone in the entire show. Naruto is a loud, hot-blooded idiot that depends on sheer determination to be great vs Sasuke who is a quiet genius that can become great through sheer intelligence -- now how well does that description fit Lee/Neji, Kiba/Shino, Kakashi/Gai, Orochimaru/Jiraiya, and much more? Even side characters have examples with Tsunade being an alcoholic gambler who just happens to be an incredibly talented ninja vs Shizune who is a strait-laced type but nowhere near as good of a ninja.
* ''Manga/AzumangaDaioh''
** The stern, mature, bookworm Yomi and goofy, [[{{Jerkass}} brash,]] [[GenkiGirl hyperactive]] Tomo.
** The same applies for the sensible, caring Nyamo, and the [[JerkAss playful]], [[ManChild irresponsible]] Yukari.
** [[ShrinkingViolet Shy, quiet]] cute-obsessed Sakaki and outgoing, impulsive Kagura's growing friendship might also count; particularly later in the season; although it seems a little more one-sided (on Kagura's part) than the other pairings.
* ''{{Mai-Otome}}'' - CountryMouse Arika Yumemiya and strait-laced #1-ranked student Nina Wang. Can also be applied to Arika and [[WellExcuseMePrincess snobby]] RebelliousPrincess Mashiro Blan de Windbloom.
* ''HidamariSketch'' - [[CreatureOfHabit Yuno]] and [[AllergicToRoutine Miyako]] have very different personalities, which doesn't prevent them from being very close. Miyako's often energetic efforts to show her feelings for Yuno are especially endearing at times.
* ''ScrappedPrincess'' - The "Beast Princess" Seness Giat and YamatoNadeshiko Eirote Borchard.
* ''LightNovel/{{Toradora}}'': Ryuuji and Taiga. He's tall, gentle, is an expert at housekeeping, likes to cook, and generally does his best to avoid conflict--unfortunately, the hereditary angry glare he got from his father makes everyone think Ryuuji's going to kill them, or worse. She's [[TheNapoleon short, brutish]], never bothers cleaning up after herself, burns salads, and has the temperament of a raging tiger--unfortunately, her pretty face and delicate figure makes strangers think she's just a cute little girl.
* ''SoulEater''
** [[{{Tsundere}} Maka]] and [[NotSoStoic Soul]] from are a pretty good example of this trope.
** [[YamatoNadeshiko Tsubaki]] and [[SmallNameBigEgo Black]] [[IdiotHero Star]] are even stronger examples.
** The groups are put together with this in mind. Opposites can [[OppositesAttract resonate their souls better.]]
** The meister/Weapon groups such as Harvar and Ox. Shinigami has a contrasting group in his named area heads, but he and scythe [[ChivalrousPervert Spirit]] are not actually ''that'' dissimilar. Though it depends on how far Shinigami's obfuscating stupidity.
*** That being noted, Shinigami is Spirit's third partner. His first was [[MadScientist Franken Stein]], and his second Maka's mother, who has, as of writing, yet to be shown, but said to be much like her daughter.
* Light Yagami and L in ''Manga/DeathNote''. Light is an [[spoiler:occasionally amnesiac]] mass-murderer who kills criminals in order to make a 'better world' with himself as God. L is the detective who's trying to catch him. And they were [[ChainedHeat HANDCUFFED TOGETHER]] for several episodes/chapters! Not to mention that Light is [[TheDandy neatly dressed]] and [[MagnificentBastard charismatic]], while L is a sloppy BunnyEarsLawyer with NoSocialSkills.
* Chiaki from ''NodameCantabile'' is a perfectionistic neat-freak who prefers good manners, yet he spends much of his time with Nodame, who is eccentric, ill-mannered, chaotic and an immense slob.
* Kanade (serious, somewhat {{Tsundere}}) and Yukino (ditzy) from ''CandyBoy''. As the story progresses, it becomes apparent that the two are more alike than they initially appeared.
* ''DarkerThanBlack''- The two Contractors, November 11 and April have this dynamic, especially in the dub. He is [[AnIcePerson cool]] and kind of fastidious (at least in respect to smoking) and always wears a [[BadassInANiceSuit suit]]. She is a HardDrinkingPartyGirl who dresses the part and has dyed hair. [[TheyFightCrime They kill people]].\\
\\
They are also SaltAndPepper; November is currently the page picture for PhenotypeStereotype while April is black, albeit with [[YouGottaHaveBlueHair blue hair]] and yellow eyes. On the other hand, they're both [[MoralityPet rather attached]] to July.
* Subaru and Teana in ''MagicalGirlLyricalNanoha [=StrikerS=]'' [[AudioAdaptation and all related releases]] where they serve as main characters. The former's too [[GenkiGirl energetic for her own good]] while the other tries to keep professional in the face of [[TheGlomp that energy]].
* Niea and Mayuko from ''{{Niea7}}'', the latter being a serious cram-school student in contrast with the boisterous, freeloading and food-stealing alien girl who lives in her cloest. Still, their relationship shows signs of a sisterly bond, which gets especially prevalent when [[spoiler:Niea goes missing]].
* A central theme in ''Anime/{{Noir}}''; Kirika and Mirielle's curious relationship is key to the plot.
** Not just ''Noir'', but all the GirlsWithGuns anime from Koichi Mashimo and Creator/BeeTrain feature this Odd Couple relationship with at least one of the protagonists. If it isn't Kirika and Mirielle, it's Anime/{{Madlax}} and Margaret...or [[Anime/ElCazadorDeLaBruja Nadie and Ellis]].
* ''TheMelancholyOfHaruhiSuzumiya'' - Haruhi and Kyon, He's a down to earth, OrdinaryHighschoolStudent, and DeadpanSnarker and she's a hyperactive GenkiGirl, who is also [[AGodAmI God]].
* ''GakuenAlice'' has a [[TheDitz Mikan]], [[EmotionlessGirl Hotari]], [[JerkWithAHeartOfGold Natsumi]], and [[FriendToAllLivingThings Luka]]. Any way you mix and match you get an Odd Couple.
* Gon and Killua in ''HunterXHunter'' probably count, because it's been pointed out that even their Nen types are complete opposites of each other. Gon's a naive, strong-willed boy from the country and Killua is a devious ex-Assassin who also happens to be very, very rich. Kurapika and Leorio probably count, too.
* And how could we forget the ultimate example. Goku and Vegeta from ''Anime/DragonBallZ'' are complete opposites that are repeatedly forced to team up, no matter how much they don't like it. It starts out as a still fairly tense EnemyMine, but by the Buu Saga we get whole episodes of them bickering and snarking at each other while [[FantasticVoyagePlot wandering Buu's innards]].
* In ''Manga/TheSecretAgreement'', Yuuichi is down to earth and realistic while Iori is impractical, otherworldly, and has very scattered attachments to actual things. On top of this there is a large wealth and class gap between them. They aren't quite a case of OppositesAttract, but in-story Yuuichi remarks to himself how they are an unlikely couple.
* The title characters of ''TigerAndBunny''. Kotetsu (Wild Tiger) is impulsive, emotional, compassionate and prone to poking his nose into other people's business. His partner Barnaby ([[EmbarrassingNickname "Bunny"]]) is asocial, aloof, relentlessly formal and generally unconcerned about anything other than [[spoiler:avenging his parents' deaths.]]
* AxisPowersHetalia: Definitely Germany and Italy. Denmark and Norway, to some extent. And maybe Canada and America.
* Detectives Ryo [=Mac=]Lean and Dee Laytner in BuddyCopShow manga ''{{Manga/FAKE}}'', who are partners with almost opposite personalities yet [[OppositesAttract attracted to each other]].
* ''Manga/{{Grenadier}}'' has this in the form of the [[TheStraightMan level-headed]], [[DoesNotLikeGuns gun-hating]] {{Samurai}} warrior Yajiro, and the [[TheDitz off-beat]], innocent [[TheGunslinger gun-slinging]] [[ForeignFanservice busty blonde]] Rushuna.
* Guardians of Death in YamiNoMatsuei always work in pairs; the manga focuses on the the goofy, playful and hyperactive Tsuzuki and the serious, down-to-earth and short-tempered Hisoka.
* Takeo and Sunahara from ''Manga/OreMonogatari''. Sunahara is the typical {{Bishonen}} high schooler you hear about and see in all sorts of manga, Takeo is a big, squarely built guy whose appearance would usually be used as {{gonk}} in other manga. And those two have been friends for over 10 years.
[[/folder]]

[[folder:Comic Books]]
* ''{{Tintin}}'' - gracile hyper-saintly jack-of-all-trades journalist meets chubby choleric, eccentric alcoholic -- who could this possibly be? Tintin and the Captain, of course.
* Comicbook/CableAndDeadpool - One: a muscle-bound, angsty psychic mutant from the future trying to make the world a better place. His buddy: a fourth-wall-breaking motormouth mercenary who is made of cancer and loves pop-culture riffs. TheyFightCrime, sort of.
* ''{{Blacksad}}'' has [[GeniusBruiser intellectual tough guy]] John Blacksad paired with [[ChivalrousPervert precocious pervert]] Weekly. They get along surprisingly well.
* Sehven and Leeka in ''Feather''. Sehv is the last dragon slayer. Leeka is the last full blooded dragon. You can see where the conflict comes from.
* Lenore and Ragamuffin in ''LenoreTheCuteLittleDeadGirl''.
* Franchise/{{Superman}} and Franchise/{{Batman}}. Superman is an alien with almost godlike powers. He can fly, lift hundreds of tons, and fire heat beams from his eyes. He was raised under generally modest circumstances and was inspired by the strong morals taught to him by his parents, and believes in [[PillarsOfMoralCharacter setting a good example for all of mankind]]. He's also happily married.\\
\\
Batman is a human, albeit an incredibly badass one. He trained his mind and body for years to gain his genius for gadgets, his mastery of combat skills, and his understanding of the mind. He is a tycoon who was inspired to be a hero by the murder of his parents, and believes in [[ScareEmStraight creating a nightmare image to scare criminals straight]]. Oh, and he's got relationship issues out the wazoo. They're practically the superhero GoodCopBadCop scenario, and yet they still acknowledge the other as their best friend.
* QuantumAndWoody, with Eric (Quantum) as the by-the-books superhero and Woody as the slapdash slob. Though Woody repeatedly insists they're "not a couple."
* SinCity has Dwight and Miho. Dwight is a down-to-Earth guy who tries to use his head while Miho is the AxCrazy assassin who never says a word. They get into conflicts a lot but Miho usually listens to him.
* There was a two issue arc in {{Spider-Man}} where he was forced to team up with ComicBook/{{Loki}} to save the world [[spoiler: and Loki's mostly-mortal kid, who the person trying to destroy the world was possessing]]. It involved a lot of wordplay between the two masters of IShallTauntYou and despite being a hero and a villain-just-doing-something-good, it was so well-written that a lot of fans remember and like it (and post it all over the web, particularly the "chili dog scene").
** It also introduced an as-of-yet unfired (and since it was written in 2003-04, probably forgotten) ChekhovsGun of Loki owing Spider-Man a favor.
* [[LukeCageHeroForHire Power Man]] and [[ComicBook/ImmortalIronFist Iron Fist]] headlined a comic together in the early '80s and this trope was invoked often in the advertising. Iron Fist comes from another world where he has mastered martial arts to an almost superhuman level. His is a life of discipline and dedication. He's also rich, but his lack of experience in the real world leaves him naive at times. Power Man, in contrast, grew up poor on the streets and knows entirely too much about how the world works, and completely lacks training and discipline, but gets by on the virtue of being super strong and nearly indestructible. Together, they're a nightmare for criminals of all sorts.
* The {{New 52}} ''All-Star Western'' pairs the ruthless, hard-as-nails, disfigured BountyHunter ComicBook/JonahHex with prissy Easterner Dr. Amadeus Arkham, who is one of the world's first criminal psychologists and a firm believer in the law and order and the humane treatment of criminals.
[[/folder]]

[[folder:Fan Fic]]
* Most of the characters in ''Fanfic/CalvinAndHobbesTheSeries'' fit this one way or another. You've got [[HotBlooded Calvin]] and [[CowardlyLion Hobbes]] themselves, as well as [[OnlySaneMan Andy]] and [[{{Jerkass}} Sherman]]. Even [[StupidEvil Dr. Brainstorm]] and [[SnarkyNonhumanSidekick Jack]] follow this!
* The ever popular pairing (sometimes romantic, sometimes just friendly) in WesternAnimation/MyLittlePonyFriendshipIsMagic fanon; Vinyl Scratch and Octavia. One's a partying, disco pumping DJ that goes by the stage name DJ PON3. The other is a refined and distinguished cellist. They are placed together to do everything from share a radio studio to [[TheyFightCrime fighting crime.]]
* In the "Pink Personal Hell" line of ''Fanfic/PinkPersonalHellAndAlteringFate'', we have an odd couple of [[GenkiGirl Pinkie Pie]], and [[ButtMonkey Dominic]]. While they get closer together, it becomes quite obvious that Pinkie moves a ''little'' too fast and is a ''little'' too hyperactive for Dominic.
[[/folder]]

[[folder:Film]]

* ''Film/InTheHeatOfTheNight'' - Virgil Tibbs (black ''and'' Northern) and Bill Gillespie (redneck).
* ''Film/TurnerAndHooch'' (1989) with Tom Hanks as the obsessive NeatFreak bachelor cop Scott Turner having to share his pristine apartment with... Hooch, a large slobbering Dogue de Bordeaux he-dog, the only witness in a murder case.
* Ken and Ray in ''InBruges''. Ken being the [[BigBrotherMentor warmhearted, wiser man]] and Ray being the impertinent, non-PC young one. Ken likes Bruges for the scenery; Ray hates it for being so boring.
* Tallahassee and Columbus in ''Film/{{Zombieland}}''. Columbus is a nervous, twitchy college student who's scared of clowns and addicted to WorldOfWarcraft. Tallahassee is a CrazyAwesome {{Badass}} who's constantly on the hunt for Twinkies and creative new ways to kill zombies. The two get along surprisingly well.
* ''Film/TheAvengers1998''. Mrs. Peel doesn't play by the rules, Steed does.
* The ''Film/LethalWeapon'' franchise. Roger Murtaugh and Martin Riggs. Murtaugh is the family man detective who just wants to remodel his house in peace, while Riggs is the crazy loner cop who tends to have a HeroicBSOD every movie.
* ''Film/{{Cherrybomb}}'' - Malachy (RupertGrint) and Luke (RobertSheehan). Malachy is a steady, dependable straight-A student with a doting middle-class family, and Luke is a loud, flamboyant drug-dealer with a taste for vandalism and violence, whose family abuse and neglect him.
* ''TheGreatRace'' - The Great Leslie is a charming male chauvinist. Maggie Dubois is a militant female chauvinist. Naturally, they fall in love and get married.
* ''Film/RedHeat''. Moscow's toughest detective, who happens to look like Arnold Schwarzenegger. Chicago's craziest cop, Jim Belushi. There's only one thing worse than making them mad. Making them partners.
* Ryan Reynolds and Jason Bateman's characters in ''The Change Up''.
* ''Film/TheHeat'' An FBI agent (SandraBullock) (not [[MissCongeniality that one]] ([[ActorAllusion probably]])) who teams up with a [[OneHeadTaller short]], [[ShoutOut slobby]], [[TomboyAndGirlyGirl crass]], [[FatAndSkinny overweight]] detective (Creator/MelissaMcCarthy); the only thing they have in common is that ''no one'' in their respective departments wants to work with them.
* ''Film/WhoFramedRogerRabbit''. Roger and Jessica Rabbit. Not the least reason is the fact that she's drawn as a human (an overly-sexy woman complete with PeekABangs) and he's a rabbit (a stereotypically-slapstick cartoon rabbit). They're married, and most Toons say ''Jessica'' got the better end of the deal.
* LaurelAndHardy
[[/folder]]

[[folder:Literature]]
* Creator/IsaacAsimov's "Robot Detective" trilogy (''Literature/TheCavesOfSteel'', ''Literature/TheNakedSun'', and ''Literature/TheRobotsOfDawn''), where the couple is an intelligent robot detective and a robot-hating human policeman. TheyFightCrime together.
* Conventional, polite nice guy John Watson and eccentric, sarcastic freelancer Literature/SherlockHolmes, who were originally forced to live together because neither of them could afford the Baker Street flat on his own.
* Miron and Joshua from ''Literature/DoraWilkSeries''. One is [[ReallyGetsAround outgoing]], social, rebellious devil who drowns checks from his father as a matter of principle. Another is ShrinkingViolet, compassionate angel who's under constant pressure from his father (ArchangelGabriel) and must live in Miron's house, as he can't afford his own. They met in Garden of Eden when they were seven and kept together ever since.
* Deconstructed in ''Literature/JohnDiesAtTheEnd'', with the relationship between John and Dave. For most of the book, Dave is seen as pretty normal, with John being the weirdo. However, as the book progresses, we discover that John is Dave's ''only'' friend, and the reason Dave still hangs around with him is because he's a codependent sociopath, and John's the 'normal' one.
* Aziraphale and Crowley from ''Literature/GoodOmens'' are, in theory, about as different as it's possible to get: they met in the Garden of Eden, where Aziraphale was the angel at the eastern gate and Crowley was the ''snake''. (They've both since been demoted.) Having worked opposite each other on Earth for countless centuries, they've realised that they have more in common with each other than they think and become best friends, still nominally working for good and evil but [[BalanceBetweenGoodAndEvil not interfering]] with each other's projects and [[GoKartingWithBowser occasionally having lunch together]]. Aziraphale is the neat, picky one while Crowley is wilder and [[CoolShades always wears]] [[HellishPupils sunglasses]].
* In ''Literature/TheWestingGame'', the sixteen main characters are paired with each other in order to solve a mystery. Most of the pairs seemingly have nothing in common with each other.
* ''Pettersson & Bendel'' - A [[ConMan Con Men]] Odd Couple. [[TheBigGuy Pettersson]] is a dashing but rather naive homeless man whom most people take to straight away; [[TheSmartGuy Bendel]] is a scrawny illegal immigrant and financial genius who must have a [[DungeonsAndDragons Charisma score]] of about -10.
* [[Literature/JeevesAndWooster Bertie Wooster and Jeeves]], to an extent. While they do fit the bill of [[UpperClassTwit nutty-goofball]] and [[TheJeeves sophistication-incarnate]], respectively, their living situation is due to a professional, master-servant relationship.
** Before Bertie and Jeeves, Creator/PGWodehouse gave us Mike Jackson the [[UnfazedEveryman doggedly ordinary]], [[ShrinkingViolet unassuming]] NiceGuy and Literature/{{Psmith}} the CrazyAwesome AttentionWhore [[HighSchoolHustler who gets away with murder]].
* ''Literature/{{Discworld}}'' - Esme Weatherwax (uptight, [[CelibateHero virginal]], constantly testing herself and others), and Gytha Ogg (easy-going, mother of fifteen, gets on well with everyone).
** Agnes Nitt and Perdita Dream. Bonus points for being the same person.
** The City Watch books have Fred Colon, a simple, down-to-earth sergeant who's [[KnowNothingKnowItAll not as smart as he thinks he is]] and Nobby Nobbs, a shifty, "certified human" corporal who's [[ObfuscatingStupidity smarter than he looks]] (which, granted, isn't ''hard'').
* ''Literature/{{Shadowleague}}'' - Zavahl, former head of the CorruptChurch and a dour man at best, and sunny Ailie in Maggie Furey's books.
* ''Literature/ThePrincessSeries'' - Snow White and Talia (Sleeping Beauty) were this back before Danielle (Cinderella) joined the team making it a trio. Snow is intelligent, immature, outgoing, wields magic, and is younger than she looks due to magic. Talia is reserved, stoic, cynical, a high level warrior, and is older than she looks due to magic.
* In ''Kidnapped'' David Balfour is a respectable(and rather priggish) lowlander and a firm Hanoverian. Alan Breck Stewart is a [[ProudWarriorRaceGuy wild Highlander]] and a well committed Jacobite.
* Nita and Nailer of ''Literature/ShipBreaker''. She's an upperclass RichBitch with a good case of SilkHidingSteel. He's a ship breaker and the son of a [[ArchnemesisDad world class monster]]. They somehow become FireForgedFriends.
* The Creator/JohnVarley novel ''Mammoth'' featured an antagonist trio of a young far-left militant and a geriatric far-right evangelical and his son. United in their opposition to cloning - the militant because he thinks cloning is a violation of animal rights and the evangelical because he thinks cloning is sacrilegious - they become terrorists.
* Noah Landau and Viktor Borovsky in Greg Rucka's ''[[Literature/QueenAndCountry A Gentleman's Game]]''. Landau is stoical, taciturn, phlegmatic, cynical, world-weary, patient, and polite; his family was almost certainly fifth aliyah or earlier. Borovsky is passionate, mirthful, profane, lustful, playful, optimistic, and earthy; he himself was born in Russia back when it was still the Soviet Union. The two of them work together at the Mossad, and somehow manage to make a very good team, even though Borovsky seems to drive Landau up the wall.
-->'''Borovsky''': I love her, I want to send her flowers....I adore her, and I want to show her my affection....What is her name again? Her real name, not the work name, not that Italian name.
-->'''Landau''': She's head of their special section. I'm sure you have it on file.
-->'''Borovsky''': I looked. Her name is Chace, Tara Chace.
-->'''Landau''': Then why are you asking me?
-->'''Borovsky''': It's more fun this way. There was no picture of her, I think it was removed. Did you remove it?
-->'''Landau''': Yes.
-->'''Borovsky''': Why?
-->'''Landau''': To keep you from drooling over it.
-->'''Borovsky''': Is she beautiful? Is she beautiful, this woman who assassinates Saudi princes?
* Louie, a timid mama's mouse and Dan, a brash slob, from ''The Porcupine Mouse''. They're brothers.
* In James Patterson's ''NYPD Red'' as the two partners meet, they have AsYouKnowBob dialog which describes him as the by-the-book straight arrow and her as the loose cannon maverick. Appropriately for a book about investigating murders of movie people, it's virtually a pitch for the movie adaptation.
* A less common version of this can be found in ''Literature/TheVampireChronicles''. Melancholic [[MemeticMutation arsonist]] Louis and adventurous [[DeadpanSnarker snarker]] Lestat. They couldn't be any more different but they still [[spoiler: love each other]].
* GarrettPI: title character and his best friend. Garrett muses that Morley stands for everything he hates, but somehow he still likes Morley.
[[/folder]]

[[folder:Live Action TV]]
* ''Series/AustinAndAlly'' - Austin and Ally are quite opposites
* ''Series/TwoAndAHalfMen'' - Charlie and Alan.
* ''Series/HawaiiFiveO'' - Mc Garrett and Dan-O are this trope.
* ''Series/SimonAndSimon'' - Rick and A.J. Simon are brothers so different in temperament that they ''had'' to be brothers for anyone to believe they'd voluntarily work together.
* Michael and Joey from ''Series/MyTwoDads''.
* Larry and Balki from ''PerfectStrangers''.
* Scully and Mulder from ''Series/TheXFiles'' (at least until Scully began to believe). And when that happened, it became Scully and Doggett.
* ''Series/TheProfessionals'' - Hot-tempered and caring Doyle and cool Bodie.
* ''{{Bones}}'' - Logical, scientific Brennan and intuitive, religious Booth.
* ''FullHouse'' had an Odd ''Trio''.
* ''Series/{{Sherlock}}'': Sherlock and John.
* ''Series/AlienNation'' - Francisco (Newcomer) and Sikes (who doesn't like Newcomers) in both the movie and the television version.
* ''Series/{{House}}'' - Gregory House and James Wilson ''define'' this trope.
* ''Series/{{Mythbusters}}'' - When the producers of what would eventually become ''Mythbusters'' first approached Jamie Hyneman regarding hosting his own show, he objected on the grounds that he is... not exactly an extrovert ("Do you actually ''have'' moods?" "No."). He suggested importing a much more outgoing colleague, Adam Savage, as co-host. The result has developed into one of the funniest, most charismatic Odd Couple pairings going.\\
\\
They more or less intentionally created a Double Act/ Comedy Duo/ Manzai, which given how often it shows up on this list, is probably a sub-trope.
* ''TopGear'' - Jeremy Clarkson (loud, brash, and confident) and James May (quiet, pragmatic, and orderly), whose [[VitriolicBestBuds on-screen bickering]] has frequently been compared to an unhappy marriage. They're good friends, however. And when you add Richard "Hamster" Hammond to Jezza and Captain Slow on the UK version of Top Gear you have one of the greatest Odd Trios ''[[CatchPhrase ...in the world]]''.
* ''Series/OzAndJames'' - James May co-presented with Oz Clarke: May plays the ignorant scruff to Clarke's long-winded pedantry. Early episodes feature May [[HypocriticalHumor complaining about how Clarke would rather talk about alcohol than drink it]]. They eventually came to the point where they enjoyed each other's company, especially once May picked up enough wine knowledge to carry on an informed conversation with Oz.
* ''Series/{{Life On Mars|2006}}'' - DI Sam Tyler and DCI Gene Hunt: an uptight, by-the-book, and slightly crazy cop trained in the modern and forensics-heavy methods of policing, and a reckless, bastardly, and semi-alcoholic cop trained in the 1970s CowboyCop method of breaking down doors and having people arrested for cattle-rustling because he needed an excuse to get them off the streets. At one point in the show, they beat each other up in a hospital room and the camera cuts to them sitting down together having a smoke and talking about their job.
* Clark Kent and Lex Luthor from ''{{Smallville}}''.
* ''TheMightyBoosh'' revolves around the relationship between Vince Noir (super-trendy, cheerful, fey social butterfly with big eyes) and Howard Moon (curmudgeony, misanthropic, mustachioed jazz-aficionado with tiny eyes). Vince is often mistaken for Howard's wife/lady friend, and Howard is often mistaken for Vince's father or geography teacher. The Odd Couple dynamic has an additional level to it, as it both mirrors and contrasts the real-life dynamic between actors Noel Fielding and Julian Barratt.
* ''Series/RedDwarf'' - Arnold Rimmer and Dave Lister. Rimmer is the uptight, regulation-following kind of person who will insist that the red-alert bulb be switched on when all of the crew members are in the same small room and are all undoubtedly already alerted and delights in quoting "Space Corps Directives". Lister, on the other hand, is described as "toffed up to the nines" when wearing a t-shirt with only one curry stain on it and pants with a hole in them that he's spray-painted himself to cover up. Though initially antagonistic, their relationship eventually becomes far more friendly.
** InvokedTrope: Red Dwarf's AI could only generate one hologram at a time, and thought Rimmer's totally opposite personality would help Lister stay sane due to the arguments and antagonism between the two.
* ''Series/{{Rome}}'' - Lucius Vorenus and Titus Pullo, with Vorenus as the uptight, honourable, stoic, by-the-book guy (with occasional [[BerserkButton cold-blooded murderous rage]]), and Pullo as the cheerfully hedonistic thug who never thinks beyond the next fight or fuck. Played with in that over the course of the series, Vorenus [[spoiler: gets [[BreakTheCutie broken down]] into a crazed nihilist while Pullo matures into a thoughtful, responsible, father and leader]].
* Sam and Dean Winchester of ''Series/{{Supernatural}}''.
* Angel and Spike in the fifth season of ''Series/{{Angel}}''. Earlier seasons had Wes and Gunn in this role.
* ''The Naked Trucker and T-Bones'':
--->'''Trucker''': "...That's why I do the drivin'-"
--->'''T-Bones''': "And I do the drinkin'."
--->'''Trucker''': "You do the talkin'."
--->'''T-Bones''': "You do the thinkin'."
* Vince and Errol from ''[[FifteenStoreysHigh 15 Storeys High]]''. Vince is a mildly eccentric misanthrope (not to the extent of being wacky, but he gets his decorating ideas from pornographic magazines), whereas Errol is naive, trusting, friendly and helpful.
* Mark and Jeremy from ''PeepShow'' are a classic example... at first glance. However, given the show's hook of giving us an insight into their thought processes, it quickly becomes clear that they're both quite equally neurotic, insecure and introverted, and in many ways Jeremy is even ''more'' socially uptight than Mark; Jeremy is desperate to be thought of as cool, edgy and sophisticated (often appearing smug, foolish and pretentious in the process) where Mark, whilst ''very'' socially inept, has fewer pretentions or illusions about himself or exactly how cool he is, and rarely bothers to put on airs as a result.\\
\\
David Mitchell and Robert Webb generally play an Odd Couple in their various collaborations, and may even be one themselves.
* Averted by ''{{Bottom}}'': Richie and Eddie are forever playing catch with the IdiotBall; there's always one stupid guy and one angry guy, but ''which is which'' is never constant, even within a single episode or a single scene.
* Hardison and Eliot from ''Series/{{Leverage}}''. The snarky, socially awkward genius and the angry, charming badass.
* ''TheSuiteLifeOfZackAndCody'' - Zack and Cody. Maddie and London count as well.
* ''MorkAndMindy''.
* ''[[Series/StarTrekTheOriginalSeries Star Trek]]'' - And Cool, logical Spock and cranky, passionate Bones, with Kirk as intermediary. [[PowerTrio Id, ego, and superego]]... InSpace!
* A game in ''WhoseLineIsItAnyway'' called Title Sequence takes suggestions from the audience of "two unlikely roommates/coworkers/etc." Thoroughly [[CrowningMomentOfFunny crowned]] in one episode where the ([[ExecutiveMeddling unfortunately nixed]]) suggestion was "Bill Cosby and Hitler".
* ''Series/TheThinBlueLine'': Ironically, despite Fowler's page quote above, he has his own Odd Couple-style relationship with Grimm, the CID inspector. Fowler is the ByTheBookCop Parody who acts like he's in ''Series/DixonOfDockGreen'', Grimm is the Wannabe CowboyCop who thinks he's in ''Series/TheSweeney''.
* The two lead characters of ''Series/{{Route 66}}'', Tod and Buz. Tod came from a wealthy family and attended Yale, and when drunk he has the tendency to reveal what a toffee-nosed snob he really could be if he weren't so nice. That is, he tells 'hilarious' stories about free tickets to the opera and being on the fencing team, while Buz sits stone-faced because he is an orphan from Hell's Kitchen.
* The two survivalists of Discovery Channel's ''Series/DualSurvival'', an ex-military guy and a hippie (imagine [[WesternAnimation/{{Cars}} Sarge and Fillmore]] being forced to play ''SurvivorMan'' together) who also have differing views on nature: the ex-military guy sees it as something to fight with while the hippie tries to live in harmony with it, to the point of always going barefoot even in 10-degree weather (which really freaks his partner out).
* Ray (either one) and Fraser of ''Series/DueSouth''.
* RogerEbert and Gene Siskel from ''At the Movies''. The hardly even ''knew'' each other before going on TV, aside from working at rival Chicago newspapers, but eventually became close friends. Their review dynamic, with Gene being more intellectual and nitpicky and Roger being more emotional and jokey made them the most popular and respected film critics in the country.
* In ''WhiteCollar'', Peter Burke is an honest, upstanding, serious FBI agent and Neal Caffrey is a charming, romantic, and tricky con artist on work release as a consultant for the FBI.
** They also clash in tidiness where the serious FBI man is messy and the con artist is the clean freak.
* ''Series/TheGoodGuys'' gives us Jack, the by-the-book cop, and Dan, the ChaoticGood cop.
* ''Series/TheAdventuresOfShirleyHolmes'': Book-smart, logical, no-nonsense, daughter-of-a-diplomat Shirley Holmes, who doesn't mind doing somehing that might get her in trouble in order to solve a mystery, and street-smart, emotion-driven, former gang member, parents-own-a-fish-market Bo Sawchuck, who is legitimately trying to get his life straight and nonetheless gets dragged into Shirley's adventures solely out of loyalty and friendship.
* Detective Inspector [[InspectorLynley Thomas Lynley]], the eighth Earl of Asherton, and his partner, cranky, working-class Detective Sergeant Barbara Havers. There's very little they do not clash on at some point. Naturally, there is also [[UndyingLoyalty nothing they would not do for each other]].
* [[VitriolicBestBuds Murdock and B. A.]] on ''Series/TheATeam''.
** Face and Murdock also qualify to some extent, although theirs is more of an OddFriendship. They're the handsome con man and the crazy pilot who just happen to be best friends. Together they pull off some of the most improbable scams with ease.
* ''LastOfTheSummerWine'', Compo and whichever [[strike: great long dollop]] third man they have at the time.
* Richard Series/{{Castle}} and Kate Beckett. He's a flippant, playboy ManChild mystery writer, she's a [[ByTheBookCop no-nonsense workaholic]] [[FairCop NYPD homicide detective]] [[BrokenBird with an unhappy past]]. TheyFightCrime And Have {{UST}}. Played with, however, in that [[HiddenDepths they're gradually revealed to have a bit more in common than they first let on]], something which only helps with the {{UST}}.
** On the same show, ThoseTwoGuys Detectives Ryan and Esposito also have a more subtle Odd Couple vibe going; Esposito's a bit of a [[TheCharmer suave, sophisticated]] ladies man where Ryan's more of a [[{{Adorkable}} clutzy-yet-lovable geek]]. This is played with in an episode where Ryan has to once again to assume the persona he used when he did undercover work some years ago. He transforms into a suave, charming Irish criminal with nerves of steel who has women swooning over him. Essentially, Ryan is quite capable acting just like Esposito but chooses not to.
* ''Series/DharmaAndGreg'': The two main characters form an Odd Couple.
* ''Series/{{Trick}}'' gives us the crime-solving duo of Ueda Jiro, physics professor, and Naoko Yamada, stage magician.
* ''NUMB3RS'' pairs Don, head of a team of FBI investigators with his mathematical prodigy of a brother Charlie. TheyFightCrime.
* In an episode of ''Series/{{NCIS}}'', Tony is [[ChainedHeat handcuffed to the criminal]], White, and also plays a criminal himself, hoping that the suspect will lead the team to his partner. Tony plays the part of a tough, down-to-earth guy who has fallen on hard times. White doesn't like getting his hands dirty, is nervous, and clearly ''not'' the brains of the operation he and his partner are involved in. [[spoiler: On the other hand, though, it turns out that White is also playing a part. He actually is the brains of the operation and is a very dangerous killer. So the fake pairing, a tough guy and a wuss, is much less odd than the real pairing, a federal agent and a psychopathic murderer.]] Despite all of this, though, at the end of the episode both admit to really coming to like the other, even after learning the other's true identity.
* Parodied on ''Series/{{Community}}'' in the episode [[Recap/CommunityS1E20TheScienceOfIllusion The Science of Illusion]], when Annie and Shirley become temporary campus security guards: She's a seriously cute recovering teen drug addict. She's a newly-single, single-mindedly Christian housewife and mother. [[TheyFightCrime They Fight Misdemeanours]]! Further parodied in that neither of them can agree on which of them gets the GoodCopBadCop role in their little partnership.
* An episode of ''{{Monk}}'' had Stottlemeyer bunk with Monk after an argument with his wife. Hilarity ensues as Monk drives Stottlemeyer crazy with his antics. Considering Monk's various issues he should have seen this coming. In the end a close to a nervous breakdown Stottlemeyer declares that he is going to beg his wife on his knees to take him back.
* ''HomeImprovement'': [[SensitiveGuyAndManlyMan Manly Man]] Tim and Sensitive Guy Al. They are united in their fondness for tools and craftsmanship.
* StephenFry and AlanDavies effectively function as this on ''{{QI}}''.
* Andrew and Bert on ''How to Be a Gentleman''.
* Lazy, extroverted, manipulative, boho-girl fashionable, borderline-anarchic Alex Russo is best friends with introverted, eccentrically dressed, somewhat nerdy MoralityPet Harper Finkle in ''WizardsOfWaverlyPlace''.
* [[SesameStreet Bert and Ernie]], right down to the stripes on their sweaters.
* In ''Series/StarskyAndHutch'', the titular characters are also a good example, though in a lesser extent. They do have different tastes in cars, food and vacation spots; for example, Hutch is a health nut while Starsky is more into junk food.
* ''{{Series/Deadwood}}'' features nebbishy Jewish businessman Sol Star and the two-fisted ex-lawman Seth Bullock.
* ''{{Series/Psych}}'': Zany, always joking Shawn has been best friends with straight-laced pharmaceutical salesman Gus for pretty much their entire lives.
[[/folder]]

[[folder:Manhwa]]
* ''Webcomic/WelcomeToRoom305'': Jung Hyun (a regular college student) ends up living with Hom, an eccentric, slobby and extremely camp.
[[/folder]]

[[folder:Professional Wrestling]]
* Odd couple tag teams are a staple in WWE.
** Daniel Bryan and Kane
** The Rock and Mankind
[[/folder]]

[[folder:Theater]]
* Nicky and Rod from ''Theatre/AvenueQ''. Their dynamic is very similar to the original Odd Couple...and thus to SesameStreet's Bert & Ernie (mentioned above) on whose personalities they were more directly based.
* OlderThanSteam: ''MuchAdoAboutNothing'' - Benedick and Beatrice.
* Blatantly used in ''AVeryPotterMusical'', in which Professor Quirrel observes that he and Voldemort are "An odd couple". Their dynamic is explained in an ensuing musical number.
[[/folder]]

[[folder:Radio]]
* Subverted by satirists [[BobAndRay Bob & Ray]], who were almost exact opposites as per this trope (slight, precise and soft-spoken vs. burly, extroverted and baritone) but could intuit each other's thoughts to the point where they could turn a chance word or phrase into a full-blown comedy skit without skipping a beat. Their character types did tend to reflect their personalities...except that big burly Ray ended up playing all the females.
* Sid and Tony in ''HancocksHalfHour''.
* Radio presenter Simon Mayo's [[RedOniBlueOni blue]] to film critic MarkKermode's [[RedOniBlueOni red]]. Kermode tends to go off into wild rants while Mayo is much more composed and cool-headed; the banter is frequently hilarious.
[[/folder]]

[[folder:Role Playing Games]]
* The ''TabletopGame/{{Shadowrun}}'' sourcebook ''Shadowbeat'' mentions a trideo show very popular in the CyberPunk world, a remake of ''The Odd Couple'' with a student hermetic magician in the role of Felix Unger and a student shaman in the role of his sloppy flatmate Madison.
[[/folder]]

[[folder:Video Games]]
* Carefully set up in ''VisualNovel/{{Snatcher}}'', where Gillian's partner, Metal, is a RobotBuddy specifically ''designed'' to have a contrasting but complimentary personality to him, to help provide a different perspective and help him concentrate on his duties.
* Can occur in many [=RPGs=]. Especially blatant in ones where your character is given a childhood friend, such as evil player character/[[NeutralGood Dawn Star]] in JadeEmpire.
* Quite well-done in KnightsOfTheOldRepublic with overly-serious and very dedicated Jedi Bastila mindlinked to a wisecracking [[spoiler:amnesiac Sith]] with an inability to take anything seriously.
* ''{{Drakengard}}'' - Caim and the dragon. Caim hates all dragons because [[DysfunctionJunction a dragon killed his parents]], and the dragon [[HumansAreTheRealMonsters hates all of humanity.]]
* Rico from {{Killzone}} is a Helghast-hating jerk and Hakha is a half-Helghast DeadpanSnarker. Much of the fun comes from watching these two talk to each other.
* In ''RivieraThePromisedLand'', Fia and Lina are roommates. Fia is quiet, wise, intelligent, a good homemaker and cautious. Lina is outgoing, emotional, klutzy, messy and constantly runs head-first into danger.
* ''{{Tsukihime}}'' - Shiki and... everyone he meets, really. They're all ''really'' weird, except Satsuki. Don't worry, Roa fixed that. But bonus points for being a vampire killer and dating the strongest non cosmic horror vampire alive, and technically being the head of a demon killing clan yet having a {{tsundere}} {{ojou}} [[HalfHumanHybrid part demon]] for a sister.
* ''FinalFantasyVIII'' - The quirky pair of Fujin and Raijin fit this trope. They both have weird speech mannerisms and are highly eccentric.
* [[TheWoobie Vivi]] and [[LawfulStupid Steiner]] in ''VideoGame/FinalFantasyIX''. Steiner is a knight captain, and he's very loud, very chivalrous, hilariously misguided, and prone to making an utter fool of himself. Vivi is a black mage, and he's quiet, introspective, under-confident at times, and pretty much universally agreed to be the most adorable thing in the ''series.'' They're insta-bros from the start of the game to its very end, and they have an awesome team-up attack they can only perform when they're both in the party. (Vivi enchants Steiner's sword, basically adding an element and a little extra oomph to Steiner's already devastating physical attacks.)
* ''VideoGame/TheWorldEndsWithYou'' - Neku and... well, ''all'' of his partners. But especially Shiki. Neku is an extreme introvert who seems to utterly ''despise'' people, whereas Shiki (at first) is your typical outgoing, fashion-obsessed teenage girl.
* Link and Midna from ''VideoGame/TheLegendOfZeldaTwilightPrincess''. He's a helpful, caring ranch hand; she's a scheming, ManipulativeBitch ([[CharacterDevelopment Or at least starts out that way]]). They actually work quite well together.
* ''VideoGame/{{Touhou}}'' has a fair share of these, such as laidback and naturally talented Reimu vs. hot-headed, hard-working Marisa, or straight-laced Youmu vs. goofball Yuyuko.
* ''VideoGame/ResidentEvil0'': Billy Coen and Rebecca Chambers. He's a cynical, bitter, thuggish escaped convict and ex-Marine in his late twenties. She's a naive eighteen year old prodigy on her first day of work as a cop. Forced to team up together to kill zombies, they develop into a highly effective team as the game progresses.
* ''FinalFantasyVII'': Serious, stoic Rude partnered up with easygoing, chatty Reno. Not only do they work very well together, but they actually [[HeterosexualLifePartners are good friends]].
* ''VideoGame/GoldenSun'' canon has the first game's villain team. Saturos is a constantly-smiling cocky trickster with a penchant for LoopholeAbuse; Menardi is more vicious and direct (and [[FunnyMoments not always in on the trickery]]). They've been partners in combat for more than three years, and are the best warriors in Prox. In canon they're a platonic Odd Couple, but in fandom they're [[FanPreferredCouple frequently portrayed as a romantic one]].
[[/folder]]

[[folder:Web Comics]]
* ''[[http://cartoons.sev.com.au/popular.php?catid=2 The Pits]]'' comic strips, by John Cook (artist of Sev Trek and the other Sev cartoons), has NeatFreak Herman suffering from ''two'' annoying sloppy bachelor flatmates: dumb womanizing Lance and the messy slacker Wayne, a textbook TrashOfTheTitans example. Things get worse when Herman gets a girlfriend.
* ''Webcomic/CaseyAndAndy''.
* ''Webcomic/ElGoonishShive'' - In the form of TrueCompanions. Tedd and Susan are an OddFriendship.
* ''{{Girly}}'' - Winter and Otra.
* ''FreakingAwfulPuns author GIROG uses an odd couple in his strips of the comic.
* In ''WapsiSquare'', the Bibliothiki is currently looked after by an odd couple of librarians. Nudge is a mythical trickster. Phix is a sphinx, and one of Nudge's former victims.
* The main theme of ''Moon Over June''. Beyond being perverted lesbian nymphomaniacs who would not know monogamy if it bit them, roommates Hatsuki 'Hats' Hasegawa (twenty-something math major[=/=]porn starlet) and Dr. Summer Winters [=Ph.D=] ([=OB/GYN=] in her late thirties) do not have a great deal in common.
* [[MoonCrest24 Dwayne and Daniel.]]
* [[CestLaVie Donna and Mona]]. One is fastidiously neat and tidy and a non-smoker, the other is French.
* ''Webcomic/JosephAndYusra'' - [[SheIsNotMyGirlFriend Alm]][[ShipTease ost]] in the form of OddFriendship. One is a NiceJewishBoy and the other is a Muslim girl. Also, they become friends through [[PsychicLink superpower]], and they are involved in lots of troubles thanks to their power and backgrounds.
* [[Webcomic/{{Homestuck}} John and Dave]]. One's a goofy, outgoing prankster with a love for bad movies, the other's a narcissistic ironic rapping roof ninja and the epitome of cool [[spoiler: hiding a massive inferiority complex]]. Dave even comments that in any other context he'd have dismissed John as a total loser, and instead they're best friends.
[[/folder]]

[[folder:Western Animation]]
* Xin Fu and Yu in ''WesternAnimation/AvatarTheLastAirbender''.
* ''WesternAnimation/TheSimpsons''
** In a spoof of Odd Couple {{Buddy Cop Show}}s [[note]]and the fact that buddy shows often have forced puns as titles[[/note]], Troy [=MacClure=] announced his new show, "Handle with Care" (in which a retired cop "Jack Handle" and a retired criminal live together. He declared "We're the original Odd Couple!"
** Referenced in "The Boy who Knew Too Much", where Skinner and Homer are sequestered in a hotel room together.
--->'''Skinner''' You know, we're kind of like the original [[Theatre/TheOddCouple Odd Couple]]. You're the messy one and...
--->'''Homer''' Shut up!
--->'''Skinner''' Oh, yes. Very well.
* ''WesternAnimation/PinkyAndTheBrain''.
* In ''WesternAnimation/JusticeLeague'', ComicBook/GreenLantern and ComicBook/TheFlash. Lampshaded once when after a fight, John uses his ring to tie up the group of villains and delivers the "Guess that's a wrap" line. After receiving stares from his teammates, he apologizes for the lame pun and states that he's been spending a lot of time with Flash.
* ''LiloAndStitch'' - Boisterous [[MadScientist evil genius]] Jumba and meek, kindly scholar Pleakely.
* ''WesternAnimation/RenAndStimpy''
* Shoehorned into ''[[WesternAnimation/SonicSatAM Sonic the Hedgehog]]'' for one of the eleven-minute Antoine episodes when Antoine is forced to live with Sonic, who becomes conspicuously more of a {{comedic sociopath|y}}. The episode is actually called "The Odd Couple".
* 'WesternAnimation/TheMrMenShow'' - Mr. Persnickety and Mr. Messy.
* ''The Imp'' and his flatmate, Bob.
* ''WesternAnimation/FamilyGuy'' - Stewie and Brian Griffin.
** Parodied in the episode "Lethal Weapons" where Chris and Meg are raking leaves and Chris employs this trope to two of the leaves:
-->"That's Randy and that's Fred. Randy's the messy one. Fred's very neat. And when you get them together, whoa! Hold onto your sides!"
** Also parodied in the episode "To Love and Die in Dixie" with the two FBI agents who watch over the Griffins' house while they stay in Bumblescum, Alabama:
-->Agent #1: "Well be watching your house together, even though hes a slovenly liberal and Im a fastidious conservative."
-->Agent #2: "I smell a sitcom!"
* ''WesternAnimation/TheOddballCouple'' with neat cat Spiffy and messy dog Fleabag.
* WesternAnimation/ChipAndDale.
* ''WesternAnimation/PhineasAndFerb'' -- while both play TheStraightMan, Phineas is the talkative, [[ZanyScheme scheming]] brother, while Ferb is quiet and calmer.
** Unlike most other examples of this trope, however, they get along perfectly and ''never'' argue--quite an accomplishment, since they're also brothers.
** Also, from the movie [[spoiler: [[MadScientist Doof]] and [[EvilOverlord Doof]]! Twice the Evil, Double Doofenschmirtz, Coming at you, Fridays!]]
** ''Ferb TV'' gives us this little sitcom staring [[MinionWithAnFInEvil Norm the Robot]] and [[DeliberatelyCuteChild Little Suzy Johnson]];
-->''He's a robot from space, she's a little girl''
-->''They come from totally different worlds''
-->''You think they're worlds apart, you're misinformed''
-->''Though it might seem unusual...That's the NORM!''
-->''That's the NORM!''
-->''That's the NORM!''
-->''That's the NORM!''
-->'''Norm:''' That's me!
* Cat and Dog in ''WesternAnimation/CatDog''.
* Robot DeFault and Monster Krumholtz in ''Robot and Monster''.
* Buck Tuddrussell and Larry 3000 of ''WesternAnimation/TimeSquad''. This leads to constant old-married-couple-like bickering. But TheyReallyDoLoveEachOther. Or not.
* The subplot of one ''{{Jimmy Two-Shoes}}'' episode was Beezy hiding out in Heloise's house, resulting in this situation.
* ''WesternAnimation/TheLooneyTunesShow'' has cool, responsible BugsBunny living with scatterbrained egoist DaffyDuck.
* On ''WesternAnimation/RockosModernLife'' there's a ShowWithinAShow about the parasites living on Spunky. Specifically, [[TheComicallySerious Bloaty the Tick]] and his buddy [[TheDitz Squirmy the Ringworm]].
* Twilight Sparkle and Spike from ''WesternAnimation/MyLittlePonyFriendshipIsMagic''. The former is an {{Adorkable}} bookworm obsessed with schedules and studying, and the latter is a baby dragon who can range from an innocent kid to a DeadpanSnarker DependingOnTheWriter. They love each other dearly, and Spike's absolute worst fear is [[CrowningMomentOfHeartWarming that Twilight will stop needing him one day and send him away.]]
** A couple of these can be perceived within Twilight's circle of friends, most popular one being [[CountryGirl Applejack]] and [[TheFashionista Rarity]].
* SpongeBob and Squidward from ''SpongeBobSquarePants'': They work together as Mr. Krabs' only two employees, and while Squidward tries to avoid seeing SpongeBob outside work, he's certainly not always successful (especially since they're also next-door neighbors).
[[/folder]]

[[folder:Other]]
* ''Gap'' has Tom and David, although Tom is only played this way from David's perspective.
* The two core characters / split personalities in [[LukeMochrieAndTheInners Film Conscience]], Phillip the Inner Pessimist and Ringo the Inner Optimist.
* Part of the initial success of ''MondayNightFootball'' in the early '70s was due to ABC's broadcast booth having one of these in Howard Cosell and Don Meredith. Cosell was openly disdainful of ex-athletes being given prime broadcasting spots and made little effort to hide his dislike of ex-Cowboys QB Meredith. Meredith thought Cosell was a snobbish KnowNothingKnowItAll. The the dramatic tension generated by their mutual antagonism helped turn ''MNF'' from an experiment into a pop culture phenomenon.
* Another sports-TV pairing: {{ESPN}}'s ''Mike and Mike in the Morning''. Mike Greenberg is a small, nerdy, germ-phobic, metrosexual neat freak, and cohost Mike Golic is a big, loud, ex-jock, man's man.
* Subverted somewhat with ventriloquist JeffDunham and ''any'' of his puppet partners, particularly Peanut and Walter. "Peanut" has pointed out several times that Jeff is essentially talking to himself. ([[YouFailLogicForever "You're arguing with yourself]] [[PunctuatedForEmphasis and losing!"]]) In other words, Jeff Dunham is his own odd couple.
* Although used often in the ImAMarvelAndImADC series in regards to the numerous characters used and the vast variety in personalities, the concept was taken to its [[CrowningMomentOfFunny most hilarious extreme]] in which {{Deadpool}} gets the crazy idea that he should be in a sitcom with none other than [[ComicBook/{{Watchmen}} Rorschach]]. [[LampshadeHanging "I smell a sitcom!"]]
* Quirrell and Voldemort in ''AVeryPotterMusical'' have a duet about this, which is blatantly lampshaded: [[http://www.youtube.com/watch?v=s3c9K6MKCIs&feature=PlayList&p=C76BE906C9D83A3A&index=4 "We're quite a kooky couple you'll agree!"]]
--> '''Quirrell:''' Aren't we the odd couple!
* The cops variant is parodied in a ''Website/{{Cracked}}'' [[http://www.cracked.com/article_18791_if-movie-characters-didnt-make-horrible-decisions_p2.html article]] with Rizzo and Flynn. Rizo likes to do things by the book. Flynn also likes to do things by the book. Together they are... Perfect Partners.
* BeavisAndButthead [[http://www.youtube.com/watch?v=TZWShS_gqsk and]] {{Cher}}.
[[/folder]]

----