->''"One pill makes you larger''
->''And one pill makes you small''
->''And the ones that mother gives you''
->''Don't do anything at all''
->''Go ask Alice, when she's ten feet tall."''
-->-- '''Music/JeffersonAirplane''', "White Rabbit"

When a character takes medication for a mental illness, they might feel that something that [[BroughtDownToNormal made them unique is taken away]]. Alternatively, the side effects make them miserable, or they might [[ConsultingMisterPuppet miss their friends]]. It is also common both in reality and fiction for individuals with a mental illness to get on their meds, become functional, then decide they are "cured" because the symptoms are gone, and come to the conclusion that they don't really need the medication any more. Other frequent causes for people deciding to stop taking their medicine includes getting [[EpiphanyTherapy some kind of epiphany]], or believing to have found the AllNaturalSnakeOil. So the character (or sometimes a parent/guardian) decides to drop the BlessedWithSuck meds, and live life insane but alive, often accompanied by a shot of the character throwing the bottle of pills in the trash.

In fictionland, this tends to result in, at worst, hangover-like withdrawal and possibly a grudging admission that the medication helped, and at best, the pills having been only a MagicFeather and it was all in their heads. Cue CrowningMomentOfHeartwarming and roll the credits. [[JustForFun/TelevisionIsTryingToKillUs Reality, however, does not work this way]]: going off of psychiatric medications without medical supervision[[note]]Or at least, weaning yourself off rather than going cold turkey like the people in these examples[[/note]] [[DontTryThisAtHome can cause serious harm or even death]]. If the medication is a burden or its side effects are worse than what's being treated, alternatives may exist if one talks to their doctor.

Covered in and used as a justification for FlowersForAlgernonSyndrome.



[[folder: Anime and Manga]]
* In ''Manga/FushigiYuugi'', Amiboshi offers Miaka a potion (that he has been given by his foster parents) that will allow her to forget all about the stresses of being a priestess, her own world, her conflict with Yui, her tumultuous relationship with Tamahome, her entrance exams, and everything else. She would then be able to live a normal life in the Universe of the Four Gods as his girlfriend. Miaka is tempted to take it, but ultimately decides against it, because even though being the Priestess has brought her a lot of stress and woe, it has also brought her a lot of good things.

* Doc Will Magnus, creator of the ComicBook/MetalMen, takes regular medication to treat his Manic/Depressive bipolar disorder with delusional episodes, but his 'stabilised' self is also less inventive. In ''ComicBook/FiftyTwo'', a group of SuperVillain MadScientist types kidnap him, confiscate his medication, and set him to work, intending to get him to recreate the DoomsdayDevice Plutonium Man that he made the last time he went nuts. However, this does not lead to the results that the mad scientist types had hoped for, [[SugarWiki/MomentOfAwesome and Magnus winds up tearing apart their criminal organization from the inside]].
--> "You shouldn't have taken away my meds! I told you... I do ''crazy'' things without my meds!"
* Todd Rice aka Obsidian of ''ComicBook/JusticeSocietyOfAmerica'' and ''ComicBook/InfinityInc'' averts this and knows he needs to take medication for his schizophrenia, and when he starts acting strangely his teammates wonder aloud if he's gotten off of it (turns out it was due to something completely unrelated).
* In ''Lab Rat'', the prequel comic to ''VideoGame/{{Portal 2}}'', Doug Rattmann avoids taking medication for his schizophrenia. [[SubvertedTrope In a subversion, however]], he recognizes he needs it, but because he's running low he saves it for when he really needs it to escape. It later turns out to be DoubleSubverted though, as the CompanionCube he had been hallucinating was giving him advice and warnings. When he takes his meds, the Cube disappeared, and Rattman nearly dies because he didn't have the Cube to warn him about a trap.
* Count Vertigo of the ''Comicbook/SuicideSquad'' didn't take medication for his bipolar disorder not because he didn't want to, but because it doesn't help. When speaking to a psychiatrist, he explains that he'd tried practically every medication to help with his disorder, but ultimately none of them stuck. Ironically, he's completely cured as a side-effect of Poison Ivy's drugs, and refuses to believe it when told the first time.
* MadArtist[=/=]MadDoctor ''Franchise/{{Batman}}'' villain Professor Pyg.
-->''You look at me like I'm out of shape. Like I drank too much and forgot my medication. I'm an artist! Who can expect me to work on antipsychotics?''
* One-shot ComicBook/{{Batman}} villain Karl Kyle, King of Cats and ComicBook/{{Catwoman}}'s brother, was ultimately revealed to be off his meds, promising to begin taking it again after Selina convinces him to end his crime spree. Later issues reveal he kept this promise, even becoming an ally to Batman.

[[folder:Fan Fiction]]
* Suggested by Rainbow Dash when she hears about Twilight's titular ''Illness'' in the fanfic of the same name. Twilight counters with a good part of the DontTryThisAtHome disclaimer above. [[spoiler:And one of the meds is a magic ''suppressor'' since it partly affects her illness.]]
* Like many mental illness tropes deconstructed in ''{{Fanfic/Brainbent}}'' when Sollux, who has rapid cycling bipolar disorder, tries going off his meds once. The results are ''not'' pretty.
* Justified in ''Fanfic/AdviceAndTrust''. The only reason Rei was taking "a giant cocktail of sedatives, dissociatives, mood suppressors, and hormonal contraceptives" was because it made it easier for Gendo to control her, and Asuka pretty much begs her to stop taking it when she finds out (Asuka had previously been put on it by her step-mother for similar reasons). Rei ends up going through several months of [[https://en.wikipedia.org/wiki/Benzodiazepine_withdrawal_syndrome#Signs_and_symptoms various withdrawal symptoms]], but slowly starts experiencing emotions as she detoxes. She also had the good sense to research the proper speed to ween herself off and obtained a counter agent to reduce the nastier side effects. After finding out, Misato mentioned that these things should really be done with medical supervision, but Rei pointed out that wasn't an option since it would be impossible for her to find a doctor that wasn't under NERV control.
* Averted during ''{{Fanfic/Uplifted}}'s'' final installment Arrival. John Hoch is one contemporary drugs to keep himself from total collapse. Problem it the only option available is ''Pertivin'' an early form for methamphetamine. His Industrialist son, John is also on prescription stabilizers in the 1990's, but with him mixing it with booze and cocaine, it seems more like genuine addiction compared to needing it.

* ''Film/GardenState'' is something of a subversion, since it's made clear he never really needed the medication in the first place. His father acted as his psychiatrist (which the film [[LampshadeHanging lampshades]] as very bad practice) and reacted quite emotionally to him [[spoiler: pushing his depressed mother in a childish outburst just as the dishwasher door accidentally opened, which caused her to fall over and become paraplegic]]. The fact that the father was unwilling to accept it as a freak accident caused him to conclude his son had intense emotional problems; hence the unnecessary medication.
* Subverted in the movie ''Film/ProzacNation'', the protagonist refuses to take her medication since she sees it as poison (she is bipolar). As a result, she loses her boyfriend, writes gibberish (writing is her passion), drops out of college and only gets better when she takes her medication, although she wonders if the medicated person is really her.
* In ''Film/ABeautifulMind'' (itself ostensibly based on John Nash's life), his anti-psychotic medication impairs his mathematical ability. Because of this, he ends up dropping it so he can continue his career. This is also subverted, since he mentions to his colleagues during the Nobel ceremony that he is taking the latest medications (probably due to the fact that modern medications have less side-effects). As well as that, when he's off the medication, he occasionally has to consult with people he's familiar with (e.g. his students) to make sure the things he's seeing are real. The RealLife Nash never got back to medication, and as a result tended not to be allowed to give speeches at his award ceremonies, for fear he'd go into anti-Semitic ranting. Ron Howard added the line to the movie specifically to avoid the negative implication toward anti-psychotic medications, but this has been decried by (some) mental health advocacy groups.
* In ''Film/ObserveAndReport'', the main character is a bit of a delusional blowhard while ''on'' his medication, but once he comes off it he becomes even more unhinged.
* Lampshaded/played with in ''Film/RepoTheGeneticOpera''. We never find out what Nathan's medicine was intended for, and it's definitely got some ''nasty'' side-effects [[spoiler: given what it does to Shilo]]. And going off it may not have made any major difference - but we don't know that it really helped either, since [[spoiler: Nathan is noticeably free-falling off the edge, if not actually leaping off of it, by the time the opera rolls around and he wasn't exactly the poster child for mental stability beforehand, and Shilo wasn't sick in the first place since Nathan was just trying to keep her in the house]].
* A rare [[InvertedTrope inversion]] in ''Film/AsGoodAsItGets'': Obsessive-compulsive Melvin starts taking medication for his disorder because LoveInterest Carol makes him want to be a better man.
-->"I've got this, what--ailment? My doctor, a shrink that I used to go to all the time, he says that in fifty or sixty percent of the cases, a pill really helps. I ''hate'' pills, very dangerous thing, pills. Hate. I'm using the word "hate" here, about pills. Hate. My compliment is, that night when you came over and told me that you would never... well, you were there, you know what you said. Well, my compliment to you is, the next morning, I started taking the pills."
* Played straight in ''Film/WhatTheBleepDoWeKnow'', when the main character tosses away her anti-anxiety medication after she starts feeling good about herself.
* In ''Film/ThorTheDarkWorld'', Dr. Erik Selvig is seen with a big bag of meds after having "had a god in [his] brain" from ''Film/{{The Avengers|2012}}'', due to thinking himself [[CloudCuckoolander crazy]] (admittedly, he's not the only one). Upon seeing a flock of birds [[TheCuckoolanderWasRight fly in an S-pattern, disappear at the start of the S-pattern, then]] ''[[TheCuckoolanderWasRight reappear flying out of the sidewalk under his, Darcy, and Ian's feet]]'', he quickly decides "There's nothing more reassuring than to know that [[WorldGoneMad the world is even crazier than you are]]" and dumps the meds in the nearest trash can.
* A really dark example in ''Film/TheVoices''. Jerry takes medication at the behest of [[ItMakesSenseInContext one of his dead victims]] one night to help with his mental illness. When they kick in, they [[spoiler: reveal that his home is not a comfy, tidy spot where he has room to cut up his victims and hide them. It's a filthy hole and the mess he made trying to cut up his victims is right out in the open. He flushes the meds down the sink and everything is back to "normal" the next day.]]

* In Creator/TerryPratchett's Literature/{{Discworld}}:
** ''Discworld/MakingMoney'': MadArtist Owlswick Jenkins is healed via turnip transplant (which leaves him quite content, but creates a seriously troubled turnip), but, alas, he loses his artistic talent. He switches back and tries some non-radical coping methods instead.
** ''Discworld/ThiefOfTime'': Jeremy Clockson has a spoonful of medication every day, as his Igor reassures a man checking on him, [[ExactWords without mentioning]] that he pours it down the sink once he found it suppressed his creativity. Of course, that creativity was being used by a manipulative benefactor to destroy the world. And then there's the fact that the last time he stopped taking his medicine, he beat his assistant to death with a hammer.
* In Creator/IsaacAsimov's short story "Light Verse", a robot that is malfunctioning is the creator of light sculptures. When its unique problem is "fixed", it can't create anymore. The robot's owner murders the scientist who fixed it, but it's noted that the victim (who has just realized that he's singlehandedly cut off what could have been a fruitful avenue of robotics research) utterly -- perhaps ''intentionally'' -- fails to defend himself.
* In ''The Phoenix Dance'', Phoenix is bipolar and becomes incredibly creative in her "up" moods, so she starts taking less of her medicine to keep the good moods. Unfortunately, this just means that her bouts of depression come back, too.
* In ''Literature/OneFlewOverTheCuckoosNest'' it is mentioned that the anti-seizure medication causes your teeth to fall out, which is a good reason why some of the patients don't want to take it. One gets the unfortunate side effect mentioned above, and decides he'd rather have the seizures; the other is terrified of having a seizure, and takes the medication intended for the first epileptic as well as his own to make sure he avoids it. In real life decreased salivation ("cotton mouth") is a side-effect of most psychoactive drugs of various kinds and daily use over a long period of time is likely to wreck your teeth.
* Serge Storms, the protagonist of the ''Florida Roadkill'' novels by Creator/TimDorsey, is supposed to be on quite a lot of anti-psychotic drugs. He often skips doses because they keep him from thinking clearly. When he skips doses for too long (Something that he is usually in the middle of doing in every single book), he goes on killing sprees.
* In the Experiment In Terror series, Dex frequently forgoes taking his antipsychotics; he prefers the mental clarity (despite the slight paranoia and hyperactivity) that comes with being sober.
* Beautifully inverted in ''Literature/ToKillAMockingbird''. When Mrs. Dubose, an elderly neighbor, calls Atticus a "nigger-lover," Jem destroys some of her flowers as a result, and as punishment, Atticus makes the boy read aloud to her every day for a month. After the punishment ends and Mrs. Dubose passes away, Atticus reveals that not only was Mrs. Dubose dying of a terminal illness, but she had become addicted to morphine to relieve the pain. She was so determined to [[DyingAsYourself die as herself]] that she stopped taking the medicine; the horrible withdrawal symptoms were only eased by Jem reading to and distracting her. Atticus says that to deny the morphine and die painfully, but clear of mind, is the bravest thing he has ever known.

[[folder:Live Action TV]]
* An episode of ''Series/BostonPublic'' had a hyperactive genius piano player, who gets put on Ritalin and doesn't want to play anymore.
* Any and all ''Series/{{Monk}}'' episodes where they try to cure Monk's OCD. He becomes really annoying and can't solve mysteries very well.
* ''Series/AllyMcBeal'' angsts that medication that takes away her hallucinations takes away her uniqueness.
* ''Series/LawAndOrder'':
** The original series was the first to explore this trope with the episode ''Pro Se''. A schizophrenic man who has been off his meds for years kills about 8 people in a clothing store. When forced to take his medication, it's revealed that he is quite the brilliant attorney and represents himself, almost beating [=McCoy=] in court. When his sister comes forth with damning testimony, he pleads out and goes back off his medication. His reasons for not taking it are the reasons many people on anti-psychotics refuse to:
--->'''James Smith''': I'm using every ounce of strength I have just to talk to you. I feel like I'm pawing through a wool blanket. I feel stiff, and like I'm half a mile behind everyone else. I get so damned tired. It takes so much effort, holding on to reality.
** A few criminals have tried to invoke this to avoid a conviction. One episode had a man suffering from parkinson's not take his medication for the trial. His constant shaking was both distracting and meant to show to the jury that it would be impossible for him to hold a gun steady. Another stopped taking his meds to induce himself into a controlled coma. Both attorneys argued that the court can't force their clients to self medicate. The argument was successful in the former, but not so much in the latter.
* ''Series/LawAndOrderSpecialVictimsUnit'':
** Several episodes featured schizophrenics of this type, who were usually forced to take drugs to testify after witnessing crimes. It explored both sides of this trope at different times. In one instance, the medication allowed the guy to get his life back together, and he eventually reunited with his estranged wife and son. Another episode had a different schizophrenic, who was so used to living with hallucinations that, when the drugs made them go away, he missed them so much he got depressed and killed himself.
** Then there's the episode where JustForFun/JohnMunch's uncle (starring Creator/JerryLewis [[AdamWesting in a performance based on himself]]) goes off his meds to punish himself for murdering a suspected rapist during a manic episode as a sort of mental {{Seppuku}}.
** Also thoroughly {{Deconstructed}} in one episode when a girl goes off her meds because a rock star tells her to, leading to her making a FalseRapeAccusation against two boys she had consensual sex with and causing a crash that kills a little girl and injured several others.
** Another episode reveals that Stabler's mother is bipolar, [[spoiler: and almost killed him during a Manic phase when he was younger]]. This coupled with her refusal to take medication because she ''wants'' the highs and lows has led him to cut off practically all contact with her, only reestablishing it [[spoiler: when his daughter presents similar symptoms]].
* ''Series/LawAndOrderCriminalIntent'': Detective Goren, who has experience with mental illness in the family, spells out the faulty thought process that often leads to this trope (when it's not a conscious choice):
-->'''Goren:''' Only sick people take pills. If I don't take my pills, I won't be sick any more.
* "Haywire" in ''Series/PrisonBreak'' loses his photographic memory (and perhaps his mathematical genius) when he takes drugs to treat his collection of mental disorders.
* Averted in ''Series/NewTricks''. If Brian "Memory" Lane stops taking his meds then, as he puts it himself (when he was speaking to a medicated schizophrenic), "I turn into Mr. Loopy, like you." A couple of episodes demonstrated this; when he didn't take his meds, he was intensely manic and unstable, and thus no good at his job.
* ''Series/{{CSI}}'': In "Recipe for Murder", a bipolar couple decide to stop taking their lithium together. The man goes completely manic, while the woman seemingly commits suicide. [[NeverSuicide The suicide ultimately turns out to be murder]], but one brought about by her decision to stop medicating.
* Tragic example: ''Series/{{Heroes}}'' Season Two's flashback episode sees Niki trying to treat her SplitPersonality with medication, only to find herself as lively as a pile of seaweed. She surreptitiously stops taking it, and soon loses control of herself again, losing her husband in the process.
* The entire premise of ''Series/UnitedStatesOfTara''--she went off her meds to discover the cause of her DID.
* ''Series/CriminalMinds'':
** Reid's schizophrenic mother went without her meds when she was pregnant with him. She goes off them again during the timeline of the series in an attempt to remember an event from Reid's past.
** The episode "Haunted" is about a man who went off his antipsychotic meds (with the approval of his psychiatrist) in order to access repressed childhood memories. These memories end up being ''much'' worse than anyone had imagined, causing him to snap and go on a killing spree.
** In another episode, the [=UnSub=] stopped taking his medication years prior following his mother's murder, resulting in a complete psychotic break. In his delusions, he views himself as a VigilanteMan when in reality he is a homicidal maniac.
* The reason Billy goes off his meds in ''Series/SixFeetUnder''.
* ''Series/{{House}}'':
** This is one of Dr. House's reasons to stop taking the Methadone, which cured his pain in the leg better than Vicodin, but he also felt that the lack of pain affected his deducting abilities. He uses the same argument in the first episodes of Season Six when Dr. Nolan insists in giving him [[http://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor SSRIs,]] he's afraid of losing himself and his abilities. He ends up taking them, anyway.
** In the episode "No More Mr. Nice Guy" occurs a little variation of this trope: House employees test a sample of his blood without his consent and discover that he has neurosyphilis. They assume that the effect of the disease in his brain is the reason House is such a huge jerk. They prescribe him with a medication. Suddenly he starts acting a little nicer. All the employees then start asking themselves whether they did the right thing or if he is going to lose what makes him so unique.[[spoiler: In the end of the episode it was all a prank of House, of course.]]
--->'''Kutner:''' We gave Van Gogh chelation therapy. Turned him into a house painter.
--->'''Taub:''' Maybe not, maybe we just put Hitler on Ritalin.
* ''Series/{{ER}}'' has this be the reason why Abby's mother keeps going off her Lithium, for her bipolar episodes. Her mother rather enjoyed her moodswings and especially loved her manic episodes. With her medication evening her out, she thought of life and herself as boring.
* Duncan spends most of an episode of ''Series/VeronicaMars'' avoiding taking his antidepressants. After jumping off a set of bleachers and injuring his head and then having an atypically vivid daydream, he ends up deciding that he's better off taking them after all. However, unlike many other examples, he actually consults a doctor regarding going off the medication.
* In ''Series/HarpersIsland'', Henry's brother J.D. needs to regularly take multiple pills. Though he tends to stop taking them now and then because it makes him feel "foggy". When he's off his pills he tends to do irrational things, [[spoiler:like gutting a deer's throat and leaving it on the hood of someone's car and smearing threatening messages on their windshield with its blood.]]
* Discussed on ''Series/{{Glee}}''. Emma finally started seeing a psychiatrist for her severe OCD and she initially rejected the notion that she should take medication. Her psychiatrist helped her understand that mental illness is like any other illness and that medication can seriously help. Her taking her meds at the end of the episode is a CrowningMomentOfHeartwarming.
* Has happened to both Craig and Eli in ''Series/{{Degrassi}}''.
** Eli's storyline with his meds has been handled fairly realistically; the first thing they put him on made him feel completely emotionless (leading to this trope) while subsequent adjustments have brought him into better balance. He also became manic a few times while he was off them.
* ''Series/{{MASH}}'' episode "White Gold": Col. Flagg is getting a self-inflicted wound in his head stitched and tells Hawkeye he wants no Novocain.
-->'''Trapper:''' You heard the maniac.
* Happens on ''Series/TheLWord'' when Alice has a nervous breakdown after Dana breaks up with her. In her case, though, she was downing pills like they were Pez and finally became sick of how dependent on them she had become.
* The show ''Series/BlackBox'' is about a psychiatrist who herself is bipolar. One of the constant themes of the show is her frequent refusal to take her meds, resulting in occasional nights of "poor decisionmaking". She also starts hearing music and runs on the streets. This also strains her relationship with her boyfriend, especially when she admits that she cheated on him once after refusing to take the meds. And then again when she tries having rough sex with him while also off her meds, only for him to be put off. He later admits that he wasn't put off by her behavior, but by the fact that he found himself ''liking'' it.
* In the ''Series/DoctorWho'' episode ''[[Recap/DoctorWhoS34E10InTheForestOfTheNight In The Forest Of The Night]]'', Maebh's medication stops her hearing the voices of the mind controlling the forest.
* In ''Series/{{NCIS}}'', a Navy Lieutenant who aspired to be a Naval aviator but washed out is revealed to have started self-medicating to treat his depression, then stopped abruptly to pass the drug portion of the civilian pilot's license exam. The sudden stop in medication is stated to have caused hallucinations and delusions which lead to him loading his plane with explosives with the intention of crashing it into an aircraft carrier. [[spoiler:Gibbs talks him out of it, but he detonates the explosives mid-air instead of landing.]]
* One episode of ''Series/TheCosbyShow'' saw Rudy spending afternoons with an elderly neighbor who didn't like to take the various medicines her doctor had prescribed. Rudy tells Cliff about it, and he rallies Vanessa, Theo, and Rudy herself to put on a short, comic play about the effects of not taking proper medications. The neighbor eventually relents and agrees to start following her doctor's orders.
* In ''Series/CrazyExGirlfriend'' one of Rebecca's first acts on moving to West Covina is to flush her all medication down the sink. Unfortunately most her problems came with her, and tossing out her anti-depressants and other meds wasn't a great idea. [[spoiler: To begin with, they were apparently what stopped her from having musical fugue episodes.]]

* The [[Music/AnimalCollective Panda Bear]] song "Take Pills" is about getting off of antidepressants.
* The Music/{{Switchfoot}} song "Mess of Me" states "There ain't no drug to make me well".
* Music/TheWall directly mentions this in the form of Pink's {{BSOD Song}} The Wall Part 3. "I don't need no walls around me./I don't need no drugs to calm me!/I have seen the writing on the wall./Don't think I need anything at all!" By this point, Pink has finally realized that he must face this issues that led him to build the wall around his emotions in the first place. [[SubvertedTrope Subverted]] in that this happens right before the last quarter of the album, [[SanitySlippage where Pink completely goes off the rails and dives straight into fascism.]]

[[folder:Stand-Up Comedy]]
* Creator/PattonOswalt has a bit where he says he went off of his depression medication because he didn't want to be burdened by it in case of a zombie attack. He describes his resulting depression like a pet dog being overjoyed to go outside and play.

[[folder: Tabletop Games]]
* An InvokedTrope in one scenario for the ''TabletopGame/TranshumanSpace'' character [[http://www.sjgames.com/pyramid/sample.html?id=5082 Shandy Xaxa Dack]], in which an Edgehunter (someone who seeks out new trends before they happen) becomes a fan of the somewhat unstable teen's poetry and wants to set her on a less self-destructive path ... but without actually using any of the easy and safe cures for mental imbalance they have in the 2100s because that might interfere with the poetry.

* Diana from ''Theatre/NextToNormal'' insists on this multiple times, most notably in "Didn't I See This Movie?", after her doctor recommends electro-shock therapy.
* Rebecca and Sara in ''Theatre/CodeTwentyOne'' feel this way, with good reason.
* In ''Theatre/BloodBrothers'', this gets slightly twisted: Mickey wants to stay on his medication for chronic depression, but his wife and mother both pressure him to quit. His wife specifically tells him that she's depressed a lot, but doesn't need any pills to get over it!

[[folder:Video Games]]
* When we first meet Gary in ''VideoGame/{{Bully}}'', he says he's taking meds for ADD and other problems. At the end of the game's first chapter, he says that he's gone off them and feels great. Because he's the main villain, this just ends up making him more unhinged.
* Depicted in ''VideoGame/FalloutNewVegas'' with Lily Bowen. Like most Nightkin, Lily has schizophrenia (she hallucinates that "[[SplitPersonality Leo]]" is telling her to do bad things) and when reduced to 1/4 HP she will lapse into a psychotic UnstoppableRage and be until every enemy in the area is dead, preventing you from bringing up the companion wheel and giving her orders or healing her (and as she is below 1/4 HP this may be a problem). She keeps some semblance of sanity due to her medication, but she only takes half the recommended dosage because taking the full dosage makes her memories hazy and she starts to forget her grandchildren. You can convince her to start taking the full dose (which stops her psychotic breaks but lowers some of her stats), keep taking half-doses, or go off her meds entirely (which triggers her psychotic breaks at 1/2 HP but buffs some of her stats). [[spoiler:If she has gone off her meds, the ending narration reveals that her mind eventually deteriorates completely and she becomes little more than a howling, bloodthirsty animal.]]
* In ''VideoGame/UntilDawn'' if Sam escapes the psycho, she can find evidence that [[spoiler: Josh]] has stopped taking their meds. [[spoiler: It turns out he's the one behind the horrors of the first chapters, and his insanity [[TalkativeLoon definitely shows]] once he's tied up in the shed.]]

[[folder:Web Comics]]
* In ''Webcomic/AMiracleOfScience'', Manny underdoses his anti-ScienceRelatedMemeticDisorder medication due to it making thinking harder, but ends up going back on the meds once he gets caught. It's never explicitly stated how much Manny altered his dosage, but Prester remarks that you have to take the full dosage for it to actually ''work'' at suppressing his SRMD. It's a nasty situation; without the meds, his programming skills can practically twist the laws of physics. With them, he's mediocre at best. Of course, without them, he's also prone to making plans of WorldDomination, whipping out an EvilLaugh, and just generally being a MadScientist.
* Subverted in ''Webcomic/GoblinHollow'' [[http://www.rhjunior.com/goblin-hollow-0353/ here.]] Penny describes her friend Tiffany who was weaning off pills, and committed suicide in one of her negative mood swings.
* In ''Webcomic/TheLastDaysOfFOXHOUND'', Ocelot throws away his medication for ChronicBackstabbingDisorder just before finally beginning the series of betrayals he's been plotting for years.

* In ''Webcomic/{{Sinfest}}'', [[http://www.sinfest.net/view.php?date=2009-05-28 Fuschia spits out her medicine.]] Given that the problem is that [[LoveRedeems falling in love is making her better]], it ends better than most.
* One strip of ''Webcomic/PennyArcade'' depicts Tycho looking over the last few strips he'd written while his Lexapro prescription had run out and marveling at his creativity. Gabe also called him out that during that time he was also [[http://penny-arcade.com/comic/2012/01/09 "wrestling with demons of the mind".]] [[WithFriendsLikeThese Gabe then reassures him that if his creativity starts slipping once he's back on his medication, Gabe will "take care of it."]]
* Discussed and deconstructed in one panel of [[http://www.robot-hugs.com/helpful-advice/ this strip]] of ''Webcomic/RobotHugs''.
* One of the AuthorAvatar's of ''Webcomic/MacHall'' and ''Webcomic/ThreePanelSoul'' takes medication for an unspecified mental problem, implied to be chronic depression and anxiety related. During one story arc of Mac Hall, he is forced to go cold turkey due to a screwup on behalf of his insurance company making him unable to refill his prescription until its sorted out. The results are ''not'' pretty, an he ends up with some pretty nasty hallucinations.

[[folder:Web Original]]
* WebVideo/GameGrumps: Danny's story about beating his depression during a trip to France, finalizing it by throwing his medication in a lake as a sign he no longer needed it. Later, he clarifies that not everyone should do this and that he got extremely lucky with being able to get away with it without repercussion.
* In the prequel comic for ''WebVideo/TheGuild'', Codex is told by her therapist that her best bet for improvement is to go on a certain kind of medication. Codex takes one look at the astonishingly LongList of [[SideEffectsInclude side-effects]] for the meds, [[ImagineSpot imagines herself suffering from all of them at once,]] and refuses.

[[folder:Western Animation]]
* ''WesternAnimation/TheSimpsons'' had one where Bart takes "Focusyn" to combat ADHD, and it makes him wicked paranoid. Major League Baseball is out to get us! Turns out...Major League Baseball ''was'' out to get us. Not quite a BrokenAesop, not quite a RuleAbidingRebel, [[RuleOfFunny just another Simpsons plot with no actual point.]]
** The doctors that gave him the medicine ''do'' say he shouldn't suddenly cease dosage -- instead recommending a variety of other meds to "ease him off" first. However, this wasn't portrayed as the standard procedure with any medication, but rather as another sign that particular drug was so dangerous no one should be using it in the first place and that all the doctors' ideas involve more drugs.
* {{Deconstructed}} in ''WesternAnimation/JusticeLeague Unlimited'', Flash villain The Trickster isn't actually a bad sort, but only taking his medication when he's "feeling down" means he's also open to the delusions that make him go out and commit crimes. At the time Flash confronts him, both over the medication and to find out information, he isn't even aware he's in costume until it's pointed out to him. Said scene was an in-joke of sorts to the dramatic difference between the short-lived live action ''Series/TheFlash1990'' series, which portrayed Trickster as an insane Joker-rip off and the comic version of Trickster, who is more or less a villainous conman, who by the late 1990s had fallen into AntiHero territory as far as aiding the Flash against his former villainous allies. The fact that cartoon Trickster was voiced by Creator/MarkHamill, who played the live action version of Trickster (as well as voicing the Joker in the Franchise/{{DCAU}}) added to the wink-wink to the audience.
* In one episode of ''WesternAnimation/KingOfTheHill'', Bobby is (apparently mis-) diagnosed with ADD, and abandoning the medication is seen as good. In another, however, Kahn goes off his manic-depression meds and despite his mania practically being a DisabilitySuperpower, it's soon apparent that he ''really needed'' those pills.
--> '''Bobby:''' There's some milk in the refrigerator that's about to go bad ... and there it goes.
* An episode of ''WesternAnimation/AmericanDad'' reveals that Steve's friend Barry, an obese, slightly retarded boy is actually a crazed diabolical mastermind, who takes on a [[EvilBrit menacing British accent]] (voiced by Creator/CraigFerguson) when off his meds.

* In one notable incident, a young girl's medication actually disrupted her synesthesia. In her case, the shock of the loss cancelled out any good the medication might have done. Her doctor had to wean her off the medication as quickly as possible, afterwards, her synesthesia returned. Subverted in that the doctor later found a medication that would address the symptoms without impacting the patient's synesthesia.