An ability or a situation that prevents the use of items. If the character's power mostly comes from his or her items, this can be a ''serious'' threat to them, even if they're high-level, and possibly one of the only ways to bring them down.

See also: NoGearLevel and MooksAteMyEquipment. In a world where superpowers come from equipment, a PowerNullifier has the same effect.

[[folder: Card Games ]]

* A number of cards in the ''Yu-Gi-Oh!'' CardGame do this: Jinzo, Royal Decree, Prohibition and Naturia Bamboo Shoot, just to name a few.


[[folder: Tabletop Games ]]

* ''TabletopGame/DungeonsAndDragons'': in 1st and 2nd Edition the Wand of Negation could prevent magic items from using their spells and spell-like functions.


[[folder: Video Games ]]

* ''Franchise/{{Pokemon}}'':
** The moves Embargo and Magic Room for any items and Heal Block for any held healing items (since Generation V), and the ability Unnerve for held Berries.
** Several more "competitive" battle environments disallow the use of any items on your Pokémon, with the only assistance allowed being held items. This included all battles against other players until ''VideoGame/PokemonBlackAndWhite'', which introduced a "Wonder Launcher" option to include items in battle.
* The White Seal floors in ''VideoGame/DarkChronicle'' do this for healing items.
* In ''VideoGame/FinalFantasyXII'', the climb up the Pharos tower requires you to make a sacrifice before proceeding up the second section (which is five floors and one BossBattle). One of the sacrifices you can choose is to give up your Items command.
* In ''VideoGame/NeedForSpeed: Hot Pursuit'' (the one by Creator/CriterionGames), the Racers can activate a Jammer weapon that not only prevents Cops within the radius of the Jammer's effect from using any weapons, but also makes the minimap disappear for Cops, reveals any Roadblocks called in beforehand and causes any Spike Strips deployed beforehand (by Cops, of course) to disappear.
* In ''VideoGame/MetalGearSolid'', your weapons are de-activated when you get into the nuclear warheads store.
* In ''VideoGame/FinalFantasyVII'', one of the random effects that can be activated while you're fighting in the Golden Saucer Arena is the deactivation of your Item-command.
* In ''VideoGame/RaidouKuzunohaVsKingAbaddon'', one possible bad result of the Luck Roulettes is not being able to use items.
* In ''VideoGame/SuperMarioRPG'', Bowyer shoots arrows to disable buttons on your controller, thus preventing Mario from either attacking, casting spells or using items. Later, in the Moleville Mines, Croco will challenge you to a fight. After he loses half of his HP, he will steal all of your items, and you won't be able to use them again until you defeat him.
* During the final fight with Bowser in the first ''VideoGame/{{Paper Mario|64}}'' game, Bowser could stomp Mario and prevent him from using items, jump attacks, or hammer attacks for a couple of turns. The Spy Guy's hammer attack can do the same thing.
** ''VideoGame/PaperMarioTheThousandYearDoor'' has a battle arena where random conditions must be followed to win a match. The inability to use items is one of those conditions.
* In ''[[VideoGame/MarioAndLuigiSuperstarSaga Mario & Luigi: Superstar Saga]]'', the Boos in Bowser's castle can steal command blocks from the brothers during a battle. Depending on which block is stolen, the brothers can't jump, use their hammers or use their hand powers for the next turn.
** The same happens during the battles with Popple.
** The BonusBoss of ''VideoGame/MarioAndLuigiBowsersInsideStory'', [[spoiler:Bowser X]], temporarily steals your special attacks as you use them.
*** The BonusBoss in ''VideoGame/MarioAndLuigiDreamTeam'', [[spoiler:Bowser Jr.]], does the same. Also, in the dream arena battles, your items are replaced with a predetermined and limited inventory, and the turn limit discourages item usage.
* Attempting to access the item screen in ''VideoGame/{{Bayonetta}}'' during an Alfheim portal challenge? You'll be greeted with [[ this]]. [[spoiler:Angel Slayer, the Lost Chapter, takes place entirely within Alfheim, and this restriction is not lifted.]]
** Because items lower your score, the entire ''game'' is this when going for Platinum trophies and the like.
** You also can't use items while fighting the BonusBoss, [[spoiler:Father Rodin]].
* Much like Bayonetta, ''VideoGame/TheWonderful101'' also restricts item usage in Kahkoo-regah. Unlike Bayonetta, there's no message if you attempt to access the item screen. You're just denied access to that section of the menu if you pause the game. [[spoiler:And once again, the special Operation 101 contains the same restriction.]]
** Item usage in regards to score is still restricted, but only to items that make combat easier. Healing items for the health and unite gauge are fair game, thankfully, and will never have ill effects.
* In ''VideoGame/DmCDevilMayCry [[UpdatedRerelease Definitive Edition]]'', the new Gods Must Die difficulty disables all consumable items and Green Orbs, making it impossible to heal Dante or Vergil should they take any damage. This is just one of many reasons why it's considered HarderThanHard.
* There are several sections of ''VideoGame/SuperMarioSunshine'' where Shadow Mario steals Mario's FLUDD (water-shooting device), thus preventing him from hovering and forcing him to stick with his basic physical abilities like jumping.
* In many {{Roguelike}}s, if an equipped item (a wielded weapon or worn piece of armor/jewelry) is cursed then it can't be removed. While the equipped cursed item can still be used like normal, this prevents the player from swapping in a different piece of equipment of the same type. Some games go further and take equipment layers into account: in ''VideoGame/NetHack'', if you're wearing cursed gloves then you'll be unable to change which rings you're wearing on your hands, since you can't take off your gloves to get at your bare fingers.
* The Arenas in most games of the ''VideoGame/TalesSeries'' prohibit item use.
** Equipping the Barbatos Ring in ''VideoGame/TalesOfVesperia'' or using a piece of equipment with the "Barbatosian" quality in ''VideoGame/TalesOfGraces'' also prevents you from using items. They're named after the infamous [[VideoGame/TalesOfDestiny2 Barbatos Goetia]], who ''[[LimitBreak really]]'' [[BerserkButton doesn't like it]] when you use items while fighting him.
** Speaking of Barbatos himself, boss fights against him throughout the series are essentially this. Oh you can use items if you dare, he'll just immediately toss a hard hitting spell at you in the original ''Destiny 2'', or a specially made Mystic Arte for such an occasion in other games.
* In most ''Franchise/TheLegendOfZelda'' games, there are items that cannot be used in all places. The most common example of this is not being allowed to use weapons when you're in someone's house. Many games in the series also feature 'cursed' enemies who often have blue flames or smoke (dark purple in ''Skyward Sword''). Instead of burning Link, they will restrict the usage of his items for as long as the effect lasts.
** The Gohma, Kalle Demos, Jalhalla, and Molgera rematches in ''VideoGame/TheLegendOfZeldaTheWindWaker'' take away any and all items that were not present in your inventory at the time of the initial battle. Link's bottle collection is left intact, however.
** The zenith of the trope occurs in ''VideoGame/TheLegendOfZeldaSpiritTracks'', where item usage as a whole is disabled during the very last fight of the Take 'Em All On! minigame.
** In ''VideoGame/TheLegendOfZeldaSkywardSword'', the [[PoisonMushroom Cursed Medal]] considerably [[MoneyMultiplier increases the drop rate of money and treasures]], but you can't open your Adventure Pouch to use items like your bottles or shield.
*** The BossRush mode of the game also disables the use of all items in your pouches except for a shield.
* ''VideoGame/AzureDreams'': Anorexia ability prevent monsters from eating consumables (i.e., the kind that heals HP or cures status ailments). They are mildly GoddamnedBats when they appear as enemies, and ''completely useless'' when they are your allies.
* Particularly {{Egregious}} example in ''VideoGame/HeroesOfMightAndMagic IV'': if a monster or character has protection from magic, they will also be unable to drink potions. So the choice is between brutally mauled by magic but able to heal, or brutally mauled by fangs/claws/fists/whatever but unable to heal.
* During one dungeon in ''VideoGame/ShadowHearts'', Yuri and Zhouzen are forced to split off from Alice and Margarete and have their ability to use items confiscated (hopefully you've leveled Zhouzen enough so that he's learned his healing spell). Alice and Margarete, meanwhile, have their skills sealed. Later, Yuri and Zhouzen have ''their'' skills sealed off, but don't get the ability to use items back until they get out of the dungeon. This isn't a complete case, though, since you can still use items outside of battle (though the game pretends otherwise).
* The SNES adaptation of ''MagicKnightRayearth'' features the Forest of Silence as in the manga and anime, but in addition to preventing the use of magic, it also (somehow) blocks the use of items.
* ''VideoGame/TeamFortress2's'' Medieval Mode takes away the ranged weapons of all but three classes (Scout, Sniper, and Medic with the Flying Guillotine, Huntsman, and Crusader's Crossbow respectively) and forces everyone to fight with melee weapons. [[ImprobableWeaponUser Stick grenades and car batteries are still allowed in though]]. As it's not a huge focus of development, this can make tremendous differences in the value of the class. For instance, it hurts the Engineer tremendously since he doesn't get any of his buildings, and his low health and subpar weapon damage turn him into a JokeCharacter nobody plays unless they're trolling.
* In ''VideoGame/MarioParty 9'', one event lets the current captain temporarily seal all the other player's special dice, keeping them from using them for their next turn.
* ''VideoGame/DarkSouls'' has the throwable "Lloyd's Talismans", which disable the use of [[HealingPotion Estus Flasks]] in a limited area. While computer-controlled enemies that use Estus are somewhat rare and generally don't have so much health that it makes a difference, they are almost a requirement when invading in PvP to keep your foe from just running away and chugging Estus every chance they get (though if someone deliberately sought out invaders to duel it's generally agreed they shouldn't be doing this anyway).
* The final battles in ''VideoGame/{{Radiant Silvergun}}'' and ''VideoGame/{{Ikaruga}}'' both disable your weapons and have you dodge their BulletHell for 60 seconds.
* TheVeryDefinitelyFinalDungeon in ''VideoGame/FinalFantasyVIII'' has restrictions on what command can be used in battle, and the restrictions can be broken by defeating the bosses in it (not too hard if you know what you're doing). The restrictions include No [[SummonMagic GF]], No Magic, and No Item.
* In ''VideoGame/ChronoTrigger'', there are a number of enemies who have the ability "Lock-All", which prevents the player from using items or techniques. The enemies that do this are all {{Metal Slime}}s, having high evasion rates, giving lots of experience, and (in some cases) dropping rare items.
* ''VideoGame/TheLastFederation'', if the player challenges Burlust warlord into a duel, his special abilities are disabled.
* ''VideoGame/MonsterHunter'' has the "stench" status, which prevents you from using items that you use on yourself. Tossing a Deodorant or stepping into another player's active Deodorant cures it. Expect to get stenched frequently when fighting Congala, who {{fart|illery}}s and [[DungFu throws excretement]] like no tomorrow.
* Picking Roo in ''VideoGame/StreetsOfRage 3'' prevents you from using any weapons until you switch to another character. Makes sense, since he's a BoxingKangaroo.
* ''Videogame/TheImpossibleQuiz'' occasionally gives you "Skip" items that lets you bypass a question, but some questions disable Skips. [[spoiler:It doesn't matter. You need all seven skips to complete the final question.]]