When ThePlague is brought about not via natural evolution or the [[SyntheticPlague machinations of science]], but is instead created through the magical powers of a person, creature, or group, whether by accident or design.

Perhaps a {{Necromancer}} is summoning dark magic to bring about the ZombieApocalypse, worshippers of the God of Disease call upon their master to bring vengeance upon their enemies, cults of EldritchAbomination obtain LovecraftianSuperpower or a shaman uses a forbidden curse in the vain hopes that it keeps his people from being wiped out. Whatever the reasons behind it, the use of disease-based magic is nearly always seen as an evil act for the sheer amount of suffering it can bring about.

Mystical Plagues need not be limited to just attacking the physical being of those who contract it, and thus are not limited to the standard vectors of transmission of common illnesses. A curse may be designed to infect the spiritual essence of a creature, or even to only [[MageKiller infect other magic users]] as they cast spells of their own. While this versatility may seem to make a magically created plague more reliable than other types, it is still not uncommon for the caster who created it to [[HoistByHisOwnPetard be killed as well]], either directly by being infected themselves, or in the aftermath that the disease's spread causes.

A subtrope of ThePlague. Compare SyntheticPlague, TheVirus, and DepopulationBomb. Can overlap with FisherKing, in cases where the Mystical Plague is caused by the actions of a kingdom's ruler. May also overlap with MaybeMagicMaybeMundane, or InMysteriousWays, if the ''exact'' cause of the problem is either not understood or not explicitly stated.



[[folder:Anime & Manga]]
* In ''Manga/KingOfThorn'', "Medusa" is a disease that came from a meteorite; spreading across the globe and turning most humans into statues. (and others into monsters). It's revealed to have a psychic vector; rather than a viral or bacterial one.

[[folder:Comic Books]]
* ''ComicBook/MarvelStarWars'' has the Crimson Forever, whose name is rather contrived - "D-dead! Everyone on board, Commander! Most of them fallen at their stations... their entire bodies turned that terrible ''crimson''...! Even their ''eyes''...! All open... ''staring''... like they were looking straight on into ''forever''...!" Luke and a squadron of pilots immediately put on masks and set up quarantine but still fell ill themselves after one of them found a red gem. It turned out there were two such gems, life-forms from beyond this galaxy who were mates, and who reacted to being separated by radiating anguish that manifested as illness and dropped people into comas deep enough that even the best medical tech was fooled. The shock of seeming to contract such a disease [[YourMindMakesItReal made most people die for real]], but since Luke had had a fever-dream that gave him insights on what to do, he revived when the gems were reunited.

[[folder:Films -- Live-Action]]
* In ''Film/UndeadOrAlive'', the "White Man's Curse" that causes its wild-west era victims to [[NotUsingTheZedWord rise from the dead and hunger for human brains]] is revealed to be a spell cast by the medicine man Geronimo before his death at the hands of the U.S. Army.
* In the universe of ''Film/TheLastWitchHunter'', TheBlackDeath plague isn't a natural disease, but a magical plague created by the Witch Queen as her take on ApocalypseHow.

* Creator/JRRTolkien seems to have liked this trope:
** ''Literature/TheSilmarillion'' mentions a plague apparently sent by Sauron to weaken Gondor so he could regain control of Mordor.
--->"And in the days of Telemnar, the third and twentieth of the line of Meneldil, a plague came upon dark winds out of the east, and it smote the King and his children, and many of the people of Gondor perished. Then the forts on the borders of Mordor were deserted, and Minas Ithil was emptied of its people; and evil entered again into the Black Land secretly, and the ashes of Gorgoroth were stirred as by a cold wind, for dark shapes gathered there."
** A mystical plague is used in the same work to account for the death of Túrin Turambar's younger sister Lalaith.
* ''Literature/TheDresdenFiles'' claims that TheBlackDeath was originally created by Fallen Angels through magic. The book ''Literature/DeathMasks'' centered on Harry recovering a religious artifact before the Fallen could use it to create another plague.
* This occurs in Mark Chadbourn's book ''The Queen of Sinister'', part of the ''Literature/TheAgeOfMisrule'' {{Verse}}. Magic has come back, technology has failed and there is [[EldritchAbomination something]] lurking beyond even the mystical otherworlds of the dead and the gods that kinda, sorta, wants to destroy humanity utterly. A mystical plague that kills human life essence itself (basically 100% fatal, and dissolves its victims flesh leaving them just a load of pus inside a bag of skin and since it comes from the otherworld there is no known vector, source, or cure for the disease) is the chosen tool for this book. Too bad for it that two of the early victims were the son and husband of a woman that is an unknowing mystical champion of humanity, and the plague which was supposed to destroy her wakes that mystical potential. NiceJobFixingItVillain.
* In ''Temple of the Winds'' of the ''Literature/SwordOfTruth'' series, [[TheEmpire The Imperial Order]] unleashes a plague, based on TheBlackDeath and made ''much'' worse by magic, on the heroes' capital city. For bonus KickTheDog points, [[BigBad Emperor Jagang]] deliberately infects a group of young children as patients zero.
* The ''Literature/SongOfTheLioness'' quartet has one early on: the Sweating Sickness is sent by an evil duke in hopes that it will weaken the kingdom and kill [[SuccessionCrisis everyone who stands in his way]] to the throne.
* Same author, [[Literature/CircleOfMagic different universe]]. ''Briar's Book'' or ''The Healing in the Vine'' ([[MarketBasedTitle depending on where you live]]) features one called The Blue Pox. Rather than being created deliberately, it's caused accidentally by improper disposal of magical potions.
* ''Literature/PhoenixAndAshes'': At one point, Alison summons a disease elemental and sets it loose; it's implied that this caused the 1918 [=H1N1=] pandemic.
* In the ''Literature/CronusChronicles'', one of our heroes, a British public school student named Zee, is sent to America to get away from one of these, not realizing he is in fact, the carrier.
* In the ''Literature/LabyrinthsOfEcho'' series Anavuayna is an ancient magic plague, borne out of an enraged Elven princess curse, that not only [[BodyHorror slowly liquifies the victim's body, bones and all]], while the victim is fully conscious, but also [[DeaderThanDead destroys their soul on every level of existence]].
* In ''Literature/TheTraitorSonCycle'', the BigBad crafts a curse that spreads and behaves like a deadly disease. It manages to scour two countries before a cure (also magical) is found.
* In the ''Literature/HarryPotter'' series there is a great deal of fear of werewolves due to misinformation and concern about the spread of Lycanthropy, a parallel to AIDS, which sufferers of are discriminated against. In ''[[Literature/HarryPotterAndThePrisonerOfAzkaban Prisoner of Azkaban]]'' Lupin resigns after Snape outs him, and in ''[[Literature/HarryPotterAndTheOrderOfThePhoenix Order of the Phoenix]]'' it is revealed that Lupin and Sirius already despise Umbridge due to some ani-werewolf legislation she wrote up that makes it near impossible for werewolves to find employment.
* In ''Literature/TheDivineComedy'', falsifiers (which include alchemists, perjurers and counterfeiters) are punished in the last bolgia in the 8th circle of hell by being afflicted by horrible diseases.

[[folder:Live-Action TV]]
* Twice on ''Series/{{Merlin|2008}}''.
** In the first season, Nimueh puts a creature into the water supply that sickens everyone in Camelot.
** Later, [[spoiler:a magical creature called a Lamia sickens an entire village AND the knights who go with Merlin when he is sent to try and stop it.]]
* The plot driver in ''Series/TheLegendOfDickAndDom''; the heroes are collecting PlotCoupons to make a magic potion to cure a plague. They discover in season two that it was magic, [[spoiler:caused by the BigBad]].
* The episode "Death at Sunset" of ''Series/PsiFactor'' deals with an inexplicable disease which kills the inhabitants of a small town one by one.
* ''Series/{{Supernatural}}'': The Croatoan Virus, which turns people into [[HatePlague rage-filled zombies]], is demonic in origin. Specifically, it was developed by the [[HorsemenOfTheApocalypse Horseman Pestilence]] on [[{{Satan}} Lucifer]]'s orders in order to herald the Apocalypse.

[[folder:Myths & Religion]]
* Miasma (as referenced in the ''Theatre/OedipusTheKing'' example below) was a part of the ancient Greek's cosmological view: If a people or their ruler acted in a way that defied the natural order (as they saw it), this was a logical consequence of said actions.
* In the Literature/BookOfExodus, a couple of the Plagues of Egypt, which God called to force the Pharaoh to free his Jewish slaves, count: the plague of pestilence (which only affected livestock) and the plague of boils (skin disease).
* If angered sufficiently, the vicious Scottish [[TheFairFolk fae]] Nuckelavee could infect horses, crops, and humans with a disease called Mortasheen.
* In Hawaiian Mythology, the normally-benevolent [[AnIcePerson Poli'ahu]] inflicted her ex-fiancé Aiwohikupua and his lover [[spoiler: Poli'ahu's [[EveryoneIsRelated sister]], Pele]] with chills and fever because [[YourCheatingHeart they snuck off together]] [[RunawayBride on what would have been Aiwohikupua and Poli'ahu's wedding day]].

[[folder:Tabletop Games]]
* ''TabletopGame/DungeonsAndDragons'':
** The Judges Guild adventure "Verbosh" had a new spell called "Plague" which causes 20-70% of the population in a 1 mile square area to be incapacitated for 1-4 weeks as well as killing many of them.
** The 2E supplement ''Tome of Magic''. The 7th level priest spell Breath of Death (reversed Breath of Life) affects an entire community. Anyone who fails a saving throw vs. death magic is infected with a disease that is fatal in 1-6 weeks.
* ''TabletopGame/{{Warhammer}}'': Nurgle mages get these kinds of spells, as do the Skaven.
** ''TabletopGame/{{Warhammer 40000}}'': see Nurgle above, except now the mages can also be seven feet tall and wearing PowerArmor.
* ''TabletopGame/{{Exalted}}'' features, among many others, the Great Contagion. Dug out of a [[EldritchLocation dimensional nexus that instills insanity in all those who view it without proper protection]] by one of the Deathlords, it killed about 90% of Creation on the first go. The only thing that stopped it from finishing the job was one of the other Deathlords inviting TheFairFolk in to finish the job; the chaotic energies of the Wyld that came with the invasion actually ''bolstered'' the immunities of the survivors.
** To clarify; not 90% of Creation's people. 90% of ''everything''. Plants, animals, spirits, gods... anything that could basically constitute "alive" in Creation was fair game. On top of that, the disease was so infectious that ''mystically observing it'' was capable of contracting it.
* One rise scenario from zombie game ''All Flesh Must Be Eaten'' has the PHADE virus, which is the zombie plague... as an STD. The whole thing started when a guy was so bereaved about the loss of his girlfriend, he used necromancy to bring her back for [[ILoveTheDead one last fling]]. And then he decided he wasn't that into her, and slept with someone else, and it just spread from there.
* ''TabletopGame/ArsMagica''. The spell "Curse of the Unportended Plague" starts a plague in a city over a period of 6-12 months. It will kill 10% of the city's population over a period of a few months.

* This is shown in Creator/{{Sophocles}}' ''Theatre/OedipusTheKing'': Oedipus's actions (killing his father, marrying his mother) unknowingly brought blight and plague ("miasma") to his people. Crops did not grow, stock animals died off, and women suffered from infertility, all because Oedipus's actions went against classical concepts of morality.

* ''Toys/{{BIONICLE}}'': The Dreaming Plague, caused by [[spoiler:Annona, a being that feasts on dreams]]. Its victims lose the ability to dream, slowly turning them violent, insane, and ultimately, dead. It almost wiped out the Iron Tribe, and the handful of survivors were shunned by all the other tribes for fear of carrying the disease.

[[folder:Video Games]]
* In ''VideoGame/{{Bloodborne}}'', the Scourge of Beast is a plague which turns people into werewolf-like creatures which is known as Beasts. [[spoiler: the twist is that the plague was spread by the blood of the [[EldritchAbomination Great One]].]]
* ''VideoGame/{{Warcraft}} 3'': The plague of undeath that turns people into zombies, preparing the way for a demonic invasion.
* The Blight disease spread by the Darkspawn in ''Franchise/DragonAge'' is said to be a curse by the [[{{God}} Maker]] upon the Tevinter Magisters, who turned into the first Darkspawn themselves under its influence. It twists and eventually kills everything infected by it. The sites of especially large darkspawn raids have been hit so hard that dead bodies won't rot because all insects and bacteria have already been killed.
** Interestingly, Avernus' research into the Taint suggests that it's alien to Thedas, with it's true origins unknown even to the denizens of the Fade, such as Spirits and Demons. Avernus believes that the key to understanding it is tied into whatever caused the corruption of the Black City.
** ''Videogame/DragonAgeInquisition'' reveals that Red Lyrium [[spoiler:is lyrium tainted by the Blight.]] This has disturbing implications: [[spoiler:since the Blight only affects living things, lyrium is alive, meaning using it is just another form of BloodMagic. The fact that Red Lyrium is found in the Primeval Thaig, which predates the First Blight, hints that the Blight existed long before the Darkspawn appeared. It didn't start with them.]]
* ''Franchise/TheElderScrolls''
** In the series backstory, the Thrassian Plague ravaged Tamriel in the 1st Era. Created by the "slug-men" Sload of Thras, the "coral kingdom" to the southwest of Tamriel, who are known to excel as [[{{Necromancy}} necromancers]] and [[EvilSorcerer Evil Sorcerers]]. The Thrassian Plague killed more than half of Tamriel's population. In response, the nations of Tamriel formed [[TheAlliance the All-Flags Navy]], which ravaged Thras, killed all of the Sload it could find, and finally sunk Thras beneath the sea. (The Sload survived, however, and would raise Thras to the surface once again.) Unsurprisingly, Peryite, the [[OurGodsAreDifferent Daedric Prince]] of [[{{Plaguemaster}} Pestilence]] and Tasks, is rumored to have been associated with the creation of the plague.
** Also from the backstory, the Knahaten Flu ravaged Tamriel in the 2nd Era for a period of about 40 years. It is attributed to an [[LizardFolk Argonian]] shaman who created the plague by manipulating the spores of the [[WiseTree Hist]] in retaliation for [[FantasticRacism the awful treatment of his people by the other races]]. Other sources claim that it was a natural disease, but the [[ReptilesAreAbhorrent general distrust of the Argonians throughout Tamriel]] combined with the fact that [[IdealIllnessImmunity Argonians were immune to the disease]] made the "Argonians caused it" story more popular. The Flu is believed to have completely wiped out the Lilmothiit "[[PettingZooPeople Fox Folk]]" and the Kothringi [[AmazingTechnicolorPopulation silver-skinned]] menfolk, both formerly native to the Black Marsh.
** ''[[VideoGame/TheElderScrollsIIIMorrowind Morrowind]]''
*** [[BigBad Dagoth Ur]]'s Blight, which spreads via Blight Storms and his minions. It can inflict crippling blight diseases and, most importantly, the Corprus Disease. The Corprus Disease is actually a curse of Dagoth Ur's (essentially divinity channeled from the [[CosmicKeystone Heart of Lorkhan]]), which brings those inflicted under his influence. It brings with it a nasty case of BodyHorror and deteriorating mental functions.
*** The Crimson Plague in ''Tribunal'' is not a standard disease, but a mystical one spread by the powerful lich Gedna Relvel. You'll need to kill her in order to stop it, and it's [[DamageSpongeBoss no easy task]].
** In ''[[VideoGame/TheElderScrollsVSkyrim Skyrim]]'', Peryite's Daedric quest involves hunting down and kill the leader of a group of his rogue followers who've been inflicted with such a plague. Before going rogue, Peryite intended to have these followers spread a this plague to "cover the world" with his "[[BlessedWithSuck blessing]]".
* At the start of ''VideoGame/NeverwinterNights'', Neverwinter is in the grip of one of these. Curing it requires body parts from four magical creatures shipped from Waterdeep. Which are promptly stolen by the group behind the plague after they arrive, forcing the PlayerCharacter to spend the first chapter recovering them.
* In ''VideoGame/{{Dishonored}}'', the rat plague initially was a virulent plague that [[spoiler:the Spymaster]] brought from the Pandyssian Continent to wipe out the poor in Dunwall. However, [[HumanoidAbomination the Outsider's]] interest was piqued and he made the plague more virulent, making all means of quarantine meaningless, and perhaps ensured the infected would become [[TechnicallyLivingZombie Weepers]]. Notably his primary 'servant', [[spoiler:[[EvilOldFolks Granny Rags]]]] seems to spread the plague by summoning more and more rats to areas. [[spoiler:You can too if you go the High Chaos route]].
* In ''Videogame/OverlordII'', the plague was caused by an event known as the Cataclysm that devastated the lands of the first game and gave rise to the AntiMagicalFaction. The ending reveals that [[spoiler:the plague was caused by Florian Greenheart, an elf born without magic who tampered with the [[ArtifactOfDoom Tower Heart]] in an attempt to gain magical powers. With the help of Rose, he then created the Glorious Empire through the anti-magic sentiment of the humans following the Cataclysm while secretly gathering magic himself.]]
* ''[[VideoGame/{{Heretic}} Heretic 2]]'' has a mystic plague as a central part of the story, mostly it causes death, insanity and violence, but there is mention of another version that can be used to control people.
* [[PlagueMaster The King of Death]] in ''VideoGame/TearsToTiara2'' summons a plague, clearly based on TheBlackDeath based on the graphics, that devastates Northern Hispania before being checked. And it continued to spread within TheEmpire, the very side that summoned it.
* The Delphinus Parasite in ''VideoGame/ShinMegamiTenseiStrangeJourney'' doubles as this and a HatePlague. [[spoiler:It's actually the inchoate form of the resident DemonLord's soul.]]

[[folder:Web Original]]
* In ''Roleplay/TheGamersAlliance'', the Blood Fever is a disease that is fatal to elves as it eats their blood cells from within and makes blood erupt from their bodies in the later stages. At first it seems like a natural plague, but over time and some investigations later it becomes apparent that the plague may in fact have a magical origin and has been created for a special purpose in which elven demise plays a part.
* The Astral Plague in ''WebVideo/TalesFromMyDDCampaign'' isn't a disease in the most technical sense of the word, as it doesn't seem to be contagious. Caused by exposure to the astral radiation from active Ytarran Teleportation Portals, the Plague wiped out the entire Ytarran race within a generation. More recently, the heroes have become infected, though they are at present shielded from the effects by a friendly spirit. However, the protection won't last forever, and the party will eventually need a cure.

[[folder:Western Animation]]
* In one episode of ''WesternAnimation/TheSmurfs'', Gargamel's EvilPlan was to spread a magical disease called the hopping cough, which caused a cough that made the victims jump violently. (The idea was that if the smurfs caught it, he could find and catch them more easily -- or in the non-Bowdlerized version, the illness was simply fatal if left untreated.) He even showed some smarts this time, and planned to ambush them at the places where the ingredients for a cure could be found. Unfortunately for the villain, he eventually [[HoistByHisOwnPetard caught it himself]] while looking for them, and Papa Smurf did indeed manage to make the cure.
* In the ''Visionaries: Knights of the Magical Light'' episode "Horn of Unicorn, Claw of Dragon", a Magical Plague strikes Prysmos, affecting all but one of the Spectral Knights and up to five of the Darkling Lords. In this case, the precise cause of the Plague is unspecified, though Merklynn does say that he foresaw it coming and tried (unsuccessfully) to send the Darkling Lords on a quest for the ingredients (the unicorn's horn and dragon's claw referred to in the title) needed for a healing spell.