[[quoteright:290:[[http://alexgarner.deviantart.com/art/Crime-Doctor-77517044 http://static.tvtropes.org/pmwiki/pub/images/crimedoctor_5710.png]]]]
[[caption-width-right:290:[[WesternAnimation/ToyStory I don't believe that man's ever been to medical school.]] ]]

->'''Penny:''' Your "arch-enemy"?\\
'''Sheldon:''' Yes, the Doctor Doom to my Mr. Fantastic. The Doctor Octopus to my Spider-Man. The Dr. Sivana to my Captain Marvel... You know, it's amazing how many supervillains have advanced degrees. Graduate schools should do a better job of screening those people out.
-->-- ''Series/TheBigBangTheory''

Science created [[DeusExNukina the atom bomb]], it [[NuclearNasty unleashes monsters]], it [[GaiasVengeance angers the gods]] -- ScienceIsBad. As a corollary to this, intelligence in media is often used for evil, or belongs to the MadScientist.

At least half of the characters in {{Comic Book}}s whose names begin with "Doctor" are evil. Even the good Doctors are often weird, being prone to [[JustThinkOfThePotential mad science]], a [[ForScience blind pursuit]] of [[ThingsManWasNotMeantToKnow forbidden knowledge]], or [[TheyCalledMeMad proving their critics wrong]].

Actual practicing ''medical doctors'' are usually exempt from the evil title, probably because it's hard not to get behind a surgeon or doctor who actively works at saving people's lives, even if they're a [[DrJerk jerk]]. Those who aren't in a MedicalDrama tend to get less slack on this, though. In a nutshell, it's a mitigating factor, not an exception. (See "MadDoctor".)

Interestingly, "Professors" aren't nearly evil as often as doctors, though Professor Blackhearts are not unheard of; this can be explained by the fact that Professor is associated with teaching, wisdom and a scholarly lifestyle (attributes of TheMentor), whereas Doctor seems to imply hands-on experience.

Notably enough, it's actually possible to get a doctorate in the study of evil. The field is called ''Ponerology'', although very few universities actually offer such a degree. ''Definitely'' issued by the AcademyOfEvil.

Compare MadScientist, which is often synonymous with this, as is EvilGenius. When they're NotThatKindOfDoctor, there's overlap with AristocratsAreEvil, in that the ''title'' is an indicator.[[note]]Given that UsefulNotes/TheUnitedStates eschewed the title system, this may well ''be'' their replacement trope.[[/note]]

Dentists and psychiatrists are technically doctors, but see DepravedDentist and PsychoPsychologist for examples of when ''they'' turn evil or insane.



[[folder:Anime & Manga]]
* ''Manga/BlackButler'' has a doctor in the manga who seems relatively normal and kind. He made prosthetic limbs for circus performers who had lived on the streets before being rescued by Baron [[spoiler:Kelvin]]. Nice, right? Sure, until we learn that those wonderfully crafted prosthetic limbs [[spoiler:were made from bones. Bones of ''children'' that were captured and kept in cages until more bones were needed. When Ciel learned this he was NOT happy.]]
** In the anime, one of the people behind the UsefulNotes/JackTheRipper case is [[spoiler:Doctor Angelina Durless. You know, Madam Red.]]
* The Doctor from ''Manga/BlackCat''. Evil. Although technically his superpower is healing (e.g. reattaching limbs), he's much more interested in the pursuit of knowledge, to the point where he's perfectly happy to [[TheydCutYouUp conduct human experiments]] and attempt to vivisect a little girl.
* In ''Manga/CageOfEden'', the closest thing the series has to a BigBad is the doctor who holds the Pyramid group in thrall with a combination of threats and psychological tricks. He gained power in the first place by spreading a disease, and then only giving the cure to those who swore loyalty to him. Except for the previous leader and said leader's daughter. Those he [[TheSociopath watched die]]. [[spoiler:And it turns out he isn't even a real doctor.]]
* Doctor Muraki from ''Manga/DescendantsOfDarkness'' who we are assured ''is'' a real doctor and we do occasionally see doing doctor-type things ... when he isn't committing murder, rape and tormenting the main characters.
** One of the doctor-like things he does is run a black-market organ-trading ring on a cruise liner. Another is encourage the cloning research of a protégé of his grandfather's... by killing women and [[YouFailBiologyForever cutting off locks of their hair for samples]].
* ''Manga/DoctorSlump'': the titular doctor, Senbei Norimaki, not only has created [[SuperPoweredRobotMeterMaids Arale]], but also creates lots of strange inventions which usually backfire in some funny way. Then, you have his enemy, Dr. Mashirito, who focuses on creating robots strangely named ''Caramel Men''.
* Doctor Gero of ''Anime/DragonBallZ''. Evil. His degree is likely in the field of engineering, and he is acknowledged as a truly brilliant scientist, if only he'd stop making evil androids and cyborgs.
** ''[[Anime/DragonBallGT GT]]'''s Dr. Myuu. Definitely evil, created the parasitic Baby. Later, teamed up with Gero to concoct an evil plan that allowed ''Hell to invade Earth''.
** On the good side, we've got Bulma's father Dr. Briefs, who is mildly eccentric (he delays an interstellar manned space journey for weeks to install a cappuccino machine in the craft) but generally helpful.
* The manga ''EDD or Eliminate Dangerous Doctors'' is this. It involves an organization whose sole purpose is to rid Morally Ambiguous Doctorates through "questionable" means (and by questionable I mean outright illegal, including murder, invasion of privacy and espionage).
* ''Manga/FrankenFran'': She isn't so much morally ambiguous as much as she is determined to keep you alive through ANY means. Borderlines on this when she's feeling spiteful of someone who wronged her. She even takes requests!
* ''Manga/FullmetalAlchemist'' has quite a few doctors since alchemy is a field of study as well as a practical military strength. Most of these doctors were working for the shadow government to create Philosopher's Stones using prisoners of war... but special mention goes to Gold-Toothed Doctor, the man responsible for the creation of Wrath, the implanting process for which took the lives of around 11 test subjects.
** Shou Tucker, who made his own wife into a talking chimera to get his State Alchemist license, and made his daughter into one to keep it. In the manga omakes, he is the only character to end up going to Hell. Which is saying something since at least one of the ones who went to heaven was a psychopath who loved blowing up people for kicks and giggles.
* [[PsychoForHire Dr. Jackal]] aka [[BloodKnight Kuroudou Akabane]], from ''Manga/GetBackers'' is quite amoral... [[EvenEvilHasStandards though not really "evil"]] (he only kills those who get in his way, and has never been known to harm [[WouldntHitAGirl women]] or [[WouldntHurtAChild children]]). Likes to slice people up with his [[BloodyMurder special scalpels]] and giggles in a rather ''unique'' way while doing so. [[spoiler:His backstory shows that he was a dedicated surgeon in the past, but then his best friend's son died despite all his efforts to save him]]...
* [[EveryoneCallsHimBarkeep The Doktor]] (sic) from ''Manga/{{Hellsing}}'': Evil. Part of a (Neo-)Nazi organisation, makes vampires and all that fun stuff. To complete the evil combo he also has [[RedRightHand a sixth finger]]. (you only notice it if you put attention in his hands as this is never mentioned in the manga)
* Dr. Jail Scaglietti of ''Anime/MagicalGirlLyricalNanoha''. BigBad inter-dimensional criminal MadScientist who specializes in [[GeneticEngineeringIsTheNewNuke biological research and manipulation]]. Definitely evil.
* ''Anime/MazingerZ'': Dr. Hell is a MadScientist and the BigBad. He also was a LargeHam. To be fair, knowledge or science did not make him evil; AbusiveParents [[FreudianExcuse and shitty early life experiences]] convinced him HumansAreBastards. He devoted himself to learn science because it helped him to keep himself sane. However, after his sanity finally slipped out due to too much abuse, he decided using his scientific knowledge to make everyone pay.
* In ''Manga/MinamotoKunMonogatari'', Minamoto Kaoruko fancies herself a sociologist, so much that she strives to re-enact [[TheTaleOfGenji the story of Hikaru Genji]] with her gynophobic nephew, Terumi, and a ''selected'' group of her students in university, [[BrokenBird each one of them with psychological traits similar to those of Genji's conquests]] and of course, this is not played for salvation or comedy. Needless to say, this screams '''unethical''' everywhere, if only for the enormous risk this poses to the fragile psyche of her subjects.
* Most of the adult characters from ''Anime/NeonGenesisEvangelion'' have doctorates in something. Examples such as Kozo Fuyutsuki (Gendo Ikari's YesMan (but with his own reasons)), Yui Ikari (TheChessmaster, according to some readings), Ritsuko Akagi ('cause committing mass 2nd degree murder [[spoiler:the dummy system]] is a sane act) and Naoko Akagi (just pure crazy, up to and including [[spoiler:murdering Rei I for calling her a "hag"]]). And all of them are pricks in one way or another.
* ''Manga/OnePiece'': Doctor Vegapunk. Not introduced yet, but his reputations far precedes him; presumably evil, and certainly eccentric. Invented a process that lets inanimate objects swallow fruit. [[note]]Though this is result of ProtagonistCenteredMorality: He is affiliated with the World Government, who are "evil" from the viewpoint of the protagonist, pirate Monkey D. Luffy.[[/note]]
** Trafalgar Law: [[SubvertedTrope Subversion]]. His reputation seemed to be painting him as this, but it turns out he is actually a decent guy, although cold and cruel at times.
** Dr. Hogback: EvilutionaryBiologist.
* [[spoiler:Scythe Master]] from ''VisualNovel/PhantomOfInferno'' is eventually revealed to have a doctorate in psychology. It explains how [[spoiler:he was able to erase Ellen and Reiji's memories, and brainwash the Zahlenschwestern into being,]] though it's subverted because he doesn't use the title of "Doctor".
* ''Franchise/SailorMoon'': Doctor Tomoe; evil, possessed, had a {{Tykebomb}} that ended up on the good side. Does a HeelFaceTurn in the [[Anime/SailorMoon first anime]] at the end of his arc.
* Dr. Nii Jianyi from ''Manga/{{Saiyuki}}'': so very, ''very'' evil. The lead scientist working for Gyokuman Koushou, He's activly trying to resurect Gyumao, an action that will likely bring about the end-of-days, because he's ''bored''. Plus, as it turns out, [[spoiler:he's actually a Sanzo, with the power to ''negate existence''.]] He's also responsible for some of the major evils in the series, such as [[spoiler: Brainwashed Kougaiji and Kami-Sama]] to name a few, particularly creepy, examples.
* The Doctor, aka William Conrad, from ''Manga/{{Trigun}}''. Evil, although reluctantly so.
* Dr. Faker from ''Anime/YuGiOhZexal''. Actually, he may have a legitimate doctorate, but he's still a MadScientist. [[spoiler: Or so we think. As it turns out, he's not very mad at all, and is more like a WellIntentionedExtremist.]]
* [[GratuitousGerman The Doktor]] from ''Anime/YuGiOhARCV''. His work involves implanting parasites into people's brains and brainwashing them. While he works for the Professor towards a [[WellIntentionedExtremist somewhat]] noble goal, the Doktor himself takes a lot of pleasure in his work. He expresses zero concern for his puppets, and talks to Yuya, simply to brag about how he can't rescue the captives.
* "Doctor" from ''Manga/YuYuHakusho'' (Chapter Black saga): Evil, [[spoiler:does a HeelFaceTurn]]. Is also an actual ''medical'' doctor. And Dr. Ichigaki, an evil, scheming MadScientist.
** The Doctor is freaking insane when Yusuke fights him. He kills at least 10 people, slices open one of the good guys' spines, slashes another one's stomach, and is generally evil. He also controls his body chemistry so that he can stay conscious the entire time while he's unleashing killer bugs. And releases endorphins so he feels good as his arm is getting shot off. He eventually is knocked out/dies briefly, but is brought back by Genkai.
*** Because although he was ''extremely'' evil, Yusuke at this point in his moral development can't handle killing a human, although killing demons has never provoked his conscience in the least. (Later on [[spoiler: after his genes activate and he's a demon, he offers to go find his ancestor Raizen some people to eat because he doesn't want the old guy to die, so apparently he gets over this.]])
*** Doctor never actually does a formal HeelFaceTurn, he just gets off Sensui's [[KillAllHumans psycho train]] and disappears into the world with a new face courtesy of his plastic surgery skills, chuckling. Later, it is mentioned in the voiceover narration that he opened a dojo dedicated to psychic surgery.

[[folder:Comic Books]]
* Doctor Doom: Evil? Yeah. You have to be pretty evil for your father to make his servant promise to always protect ''the world'' from ''you'', ''when you're a little boy''.
** He's closer to a WellIntentionedExtremist and NobleDemon if anything, also not a real doctor.
** At best, while he's certainly done enough original work to deserve several doctorates, he's got a degree from the University of Latveria after he took over the country. Remember, he was disfigured when still a student at "State U." and expelled for causing the explosion. Oddly enough, he goes by doctor, while the legitimately multi-doctorate-degreed Reed Richards goes by mister in his super-id.
** And then there's Doom's lesser-known cousin, Doctor Bob Doom, DDS, a one-shot ComicBook/SheHulk villain.
* ''ComicBook/SpiderMan'': ComicBook/DoctorOctopus: Ambiguously evil. [[RedemptionEqualsDeath Does the right thing]] in the [[Film/SpiderMan2 movie]]. (Actually, he does hold an actual doctorate, although [[NotThatKindOfDoctor it isn't in medicine.]])
* Dr. Jonas Harrow, occasional Spider-Man villain who is responsible for the Kangaroo and Hammerhead becoming villains; evil MadScientist, and [[IneffectualSympatheticVillain not a very good one]]. He once did have a license to practice medicine, but he lost it for practicing illegal experiments.
* ''Comicbook/DoctorStrange'': Doctor Stephen Strange: [[TheAtoner Formerly]] a brilliant but [[DrJerk callous and egotistical]] young surgeon. Currently [[BunnyEarsLawyer good, but eccentric]], possessing a lot of arcane knowledge he really doesn't have time to explain to you, so just stand back and let him save the day already.
* ''Franchise/{{Batman}}'':
** Doctor Hugo Strange: Sane enough to hold a doctorate in psychiatry; too insane to perform surgery. (Monstrous enough to try anyway). Though subverted in that despite holding a doctorate, he's never actually called Doctor Strange (possibly due to the above), rather, he's always called ''Professor''.
** Before becoming Scarecrow, Jonathan Crane held a doctorate in psychology.
** Nominally inverted by Victor Fries -- while he ''does'' have a doctorate, his supervillain name drops the "Dr." in favor of "Mr. Freeze."
** Doctor Simon [[NamesToRunAwayFromReallyFast Hurt]]: Evil.
** Poison Ivy and Harley Quinn also have doctorates, although whether Harley earned hers [[DependingOnTheWriter depends on the writer.]]
* ''Franchise/TheDCU'':
** Doctor Poison, Doctor Cyber, and (with what is probably the best super-villain name ever) Doctor Psycho: Evil. According to the ''WesternAnimation/BatmanTheBraveAndTheBold'' tie-in comic, Doctor Cyber has multiple [=PhDs=] in ''[[NotThatKindOfDoctor literature]]''.
** Doctor Phosphorus: Evil... albeit with some justification.
** The Crime Doctor (pictured above): Evil ... depending on the continuity. Pre-ComicBook/{{Crisis|on Infinite Earths}} he was moderately evil; a gang boss who still held by his InconvenientHippocraticOath. In ''WesternAnimation/BatmanTheAnimatedSeries'' he was good, but pressurized into becoming a mob doctor by his evil brother. ComicBook/PostCrisis, he's a bona fide MadDoctor, a serial killer who wears EltonJohn sunglasses (taken as a trophy from his first victim, a female med student).
** Dr. Quinzell, Dr. Isley, Dr. Crane and Dr. Elliot? [[note]](Harley Quinn, Poison Ivy, Scarecrow and Hush repectively)[[/note]]
*** Those may actually qualify as an aversion. While they ARE Doctors, their villainous names don't contain the title.
*** That aversion also applies to King Tut AKA The Pharaoh. He is also a professor and most likely a Ph.D., but Doctor isn't part of his villainous name, either.
** Doctor Light: Two of them in Franchise/TheDCU, the male one (who also uses his surname as his moniker - Arthur Light) is evil, the female one is good [[DefrostingIceQueen (but very abrasive)]]. It helps that the female Dr. Light happens to be a practicing medical doctor as well as an [[OmnidisciplinaryScientist all-around scientist]].
** Doctor Impossible from the DCU. Evil.
* Doctor Alchemy: at least [[SuperpoweredEvilSide 50%]] evil.
* ''MarvelUniverse'': Doctor Demonicus: Evil.
* The Doctor, from ''ComicBook/TheAuthority'': Good, if often stoned and quite weird. Though able and willing to do some really nasty stuff in the name of good. Taking a country and freezing it briefly in time so it and all its inhabitants end up frozen and exploded in space, anyone?
** Several characters in the {{Creator/Wildstorm}} universe (where Authority takes place) have held the title of "The Doctor," but only the so-called "renegade" Doctor was explicitly said to be an actual doctor, being a heart surgeon. And, ironically, evil. The one given above was a (former) multi-media/dotcom billionaire and his successor was a Palestinian suicide bomber before getting his powers (also good).
* ''{{Shazam}}'': Doctor Sivana: Evil ''[[CardCarryingVillain and loving it]]'', and [[MadScientist stark raving insane]].
* ''ComicBook/BlakeAndMortimer'': Dr. Voronov: Evil, wants to use a virus in order to wipe out world-leaders. Doesn't hesitate to use children as part of his schemes.
* Dr. Niles Caulder, AKA, the Chief. [[GoodIsNotNice Technically a hero]], but caused the disasters that made the Comicbook/DoomPatrol metahumans and made them superheroes just to study them. He also tries to keep them in line through emotional manipulation and the most likely empty promise of making them normal again.
* Doc Magnus, creator of the ComicBook/MetalMen. Good, although he spent a DorkAge brainwashed into a would-be world conqueror.
* ''Franchise/{{Tintin}}'':
** Dr. J.W. Müller: Evil.
** Dr. Krollspell: Evil (with a loose resemblance to Dr. Mengele), but later switches sides after finding out that his employer, the BigBad Roberto Rastapopoulos, intends to kill him.
** Cuthbert Calculus probably has several real and honorary doctorates, but is usually called Professor Calculus.
* Doctor Destiny. [[YourWorstNightmare Evil]]. DreamWeaver.
* The Surgeon General of ''ComicBook/GiveMeLiberty'', a literal MadDoctor.
* Lampshaded in ''ComicBook/{{Pafman}}'', when a [[OurCentaursAreDifferent centaur]] villain presents himself as "Professor Sagittarius" and the main character complains "(All villains) are either professors or doctors".
* Doctors Tony Stark from ''ComicBook/IronMan'', Reed Richards from ''ComicBook/FantasticFour'' and Bruce Banner from ''TheIncredibleHulk''. Good, but often with major JerkAss tendencies.
* Dr. Mid-Nite from the DCU is a (super)heroic physician. An aversion, since he's definitely Good and not even a jerk.
** When they first meet, Black Canary is surprised to realize Mid-Nite really is a doctor. "Let's just say I've met a few Doctor Fill-in-the-blank types who didn't come close to the Hippocratic Oath."
* ComicBook/DoctorFate from the DCU has a complicated history. He's Good in a cosmic sense, but this may or may not translate to giving much of a damn about humanity (especially in the versions where Doctor Fate is actually being ''possessed'' by a Lord of Order as opposed to simply being a person in a costume), and in most incarnations doesn't actually hold an earned doctorate anyway.[[note]]The exception is Dr. Kent Nelson, the Golden Age Dr Fate, who was an archaeologist/Egyptologist and then later ''also'' became a medical doctor.[[/note]]
* A rather humorous example: ComicBook/HowardTheDuck's foe Dr. Bong is a MadScientist and not a real doctor, but years after his conflict with Howard, he tries to earn a legitimate [=PhD=] in psychology. Unfortunately, his first patient during his internship is ComicBook/{{Deadpool}}, and suffice to say, that kind of messed things up...
* ''ComicBook/TransformersMoreThanMeetsTheEye'''s Pharma, a rare example of a character who manages to be this ''despite'' being an actual practicing well-respected medical doctor (at first, at least; he loses the job after [[PlagueMaster attacking the facility he works at with a virus]] that [[BodyHorror liquefies the victim's internal organs]]).
* In ''Franchise/{{Superman}}'', Emil Hamilton started as a minor antagonist who quickly became Superman's go-to guy for technical know how. He eventually became a villain.

[[folder:Comic Strips]]
* ''ComicStrip/InkPen'' MadScientist "Mr. Negato" admits [[http://www.gocomics.com/inkpen/2008/07/15 that he was denied his degree.]]

[[folder:Fan Works]]
* ''Fanfic/CalvinAndHobbesTheSeries'' has Dr. Brainstorm, although he's usually a HarmlessVillain and finds himself in an EnemyMine situation twice.
* ''[[https://www.fanfiction.net/s/8688354/1/Crucible Crucible]]'' has Dr. Swan, a man who wanted to make his career by imprisoning an apparently amnesiac man to perform illegal treatments on him (which included direct electro brain stimulation). When the patient escaped with one of his nurses and years later, when the woman came back to look for jobs after her husband's death, he took revenge by forcing her into prostitution and later drowning her in drug abuses until she died from overdose and [[Characters/MassEffectCommanderShepard her daughter]] was adopted. Karma came to bite him in the ass when her dead husband, [[spoiler: who turned out to be the previously sealed GrimReaper]] gave him [[FateWorseThanDeath a punishment]].
* [[KnightOfCerebus Professor Kabuto]] from ''Fanfic/PonyPOVSeries'' certainly counts. The Changelings' psychotic Alchemist Master and resident MadDoctor, Kabuto views all other creatures as potential test subjects for his horrific experiments, which in the past has resulted in countless deaths of both other creatures and his own kind. He repeatedly attempts to get permission to or attempt to vivisect the mane cast and the other heroes he comes in conflict with. He also plays this trope literally, as he has a doctorate of some sort.
* Averted with Dr. Sawbones from ''FanFic/TheRiseOfDarthVulcan''. Yeah he works for Vulcan and the Diamond Dogs, but only because he is a very dedicated doctor, with the compulsion to treat any injured creature that appears before him, no matter their allegiance, and is clearly disgusted by other quack medical theories, like the ones that encourage thestrals (batponies) to be malnourished, by preventing them getting the meat and blood they need to ''survive''.

[[folder:Films -- Animation]]
* ''Disney/LiloAndStitch'': Dr. Jumba Jookiba: Self proclaimed "EvilGenius." Not all that threatening, though.
** Likewise, Dr. Jacques von Hamsterviel in ''WesternAnimation/LiloAndStitchTheSeries''.
* Creator/KeithDavid as Dr. Facilier from ''Disney/ThePrincessAndTheFrog''. He's a ''witch'' doctor. And an evil one, since you ask.
* The former page quote comes from ''WesternAnimation/ToyStory'', when Buzz and Woody witness the sadistic Sid play doctor, sewing a plastic pterodactyl head onto his sister's doll's neck.
* Played with in ''WesternAnimation/ToyStory3'':
--> '''Buzz''': Evil Doctor Porkchop!
--> '''Hamm''': That's Mister Evil Doctor Porkchop to you!
* Doctor Cockroach, [=PhD=] in ''WesternAnimation/MonstersVsAliens''. His doctorate is in ''dance.''

[[folder:Films -- Live-Action]]
* Dr. T, from the movie ''Film/The5000FingersOfDrT'', is an evil...piano teacher. The trope is subverted, however, by the writer of the film, who is most definitely good...Creator/DrSeuss.
* ''Film/TheAbominableDrPhibes'': Well, the clarifier gives it away, doesn't it? Evil, in a [[WoobieDestroyerOfWorlds woobielicious]] sort of way, and terrifyingly inventive.
* The main villain of the film ''Film/{{Amen}}'' is credited only as [[EveryoneCallsHimBarkeep The Doctor]], and is a member of [[ThoseWackyNazis the SS]] supervising the extermination camps.
* In ''Film/TheAmericanAstronaut'', Professor Hess: Not as much "bad" as "batshit insane".
* ''Film/AustinPowers'': Doctor Evil: He didn't spend six years at frickin' Evil Medical School to be called "Mister", thank you very much.
* Perhaps Doc Brown from ''Franchise/BackToTheFuture'' escapes this trope because he's not known as "Dr. Brown. Or perhaps because he is not evil. He does steal a train but it's only to save Marty not an evil scheme or for science. He jokes it is a science experiment, but it wasn't.
* ''Film/TheCabinetOfDrCaligari'': Dr. Caligari: Evil, but only [[spoiler:within [[CuckooNest the hero's mind]].]]
* Very common in Creator/DavidCronenberg's films, although there's rarely a pure-good or pure-evil doctor.
** ''Film/TheFly1986'': Dr. Seth Brundle is really sweet. Brundlefly, however, is not.
** ''Film/DeadRingers'': Doctors Elliot and Beverly Mantle are... [[CreepyTwins really fucking creepy]].
** ''Film/{{Scanners}}'': Dr. Paul Ruth is ''[[GuineaPigFamily very]]'' unethical, but not really an antagonist.
** ''Film/TheBrood'': Dr. Hal Raglan is also a bit unethical, and a bit of a fuck-up, but [[RedemptionEqualsDeath not really]] [[HeroicSacrifice evil]].
** ''Film/{{Rabid}}'': Dr. Dan Keloid is okay, until he turns into a zombie.
** ''Film/{{Shivers}}'': Dr. Emil Hobbes is crazy. Dr. Roger St. Luc is okay, until he turns into a rape zombie. Yes, you read that right. ''Shivers'' is a screwed-up movie.
* Creator/VincentPrice's character in ''Dr. Goldfoot and the Bikini Machine'': fairly evil.
* Dr. Mabuse, from a number of German films beginning with ''Film/DrMabuseTheGambler'' in 1922. Not only is he one of the original criminal masterminds, but he also uses "telepathic hypnosis" to force others to do his will. What's his ultimate goal? To spread as much fear and terror as possible and destroy the world, ''then'' rule it. Yikes. Luckily, his own self-destructive tendencies ("M'abuse" is French for "I abuse myself") make him his own worst enemy.
* ''Film/DrStrangelove'': Probably ChaoticNeutral.
* ''Film/TheEvilThatMenDo'' (1984). Dr Clement [[NamesToRunAwayFromReallyFast Molloch]] advises South American dictatorships on how to torture people. He is definitely evil.
* ''Film/ForbiddenPlanet'': Doctor Morbius is unconsciously evil, because WithGreatPowerComesGreatInsanity. Awake, he's just [[DrJerk a grouch]].
* Peter Venkman in ''Franchise/{{Ghostbusters}}'', who [[NotThatKindOfDoctor has a degree in parapsychology]], usually only falls into the DoctorJerk territory. However, at the beginning of the [[Film/{{Ghostbusters 1984}} first film]] he was worse, lying during a test on volunteers, simply because he didn't want to inflict the painful punishment on the attractive female one (much to the dismay of the other one).
* ''Film/HouseOf1000Corpses'''s Dr. Satan. Evil through and through, but he is arguably the best-named doctor of all time.
* ''Film/TheHumanCentipede'': Dr. Heiter: A man with a vision. A vision that humanity cannot accept in any means, for good reason.
* ''Film/JamesBond'':
** ''Film/DrNo'': Very evil and a MadScientist to boot.
** ''Film/TomorrowNeverDies'': Dr. Kaufman. AffablyEvil but sadistic and cruel underneath. A professor of forensic science, who can [[MemeticMutation zhoot you from Stuttgart und still create ze illusion of suicide]]. He is also an expert in torture, but he calls ''that'' a "just a hobby".
* A very subtle example in ''Film/JoeVersusTheVolcano''. In the beginning, the protagonist is told by an apparently well-meaning doctor named Dr. Ellison that he has six months to live, due to an incurable condition called a "brain cloud". This is what inspires Joe to accept Graynamore's offer to volunteer as a HumanSacrifice for the natives he wants to make a deal with. [[spoiler:It isn't until the final scene of the movie that Patricia tells him that Ellison is actually Graynamore's personal physician, meaning he's was likely lying to set Joe up, making Ellison an immoral violator of the Hippocratic Oath.]]
* Doctor Miller is the [[EvilVersusEvil evillest]] character in ''Film/TheLegendOfFrenchieKing'', being responsible for the only death in the whole movie [[spoiler:(besides his own)]] and suffering from LackOfEmpathy. However, he's a non-threat for most of it due to being incapacitated.
* The BMovie spoof ''Film/TheLostSkeletonOfCadavra'' has both a good and evil scientist, both of whom are doctors.
* Dr. Rotwang, from ''Film/{{Metropolis}}'': The ultimate MadScientist, so yeah. Evil. Though if having a name like "Rotwang" isn't a FreudianExcuse, nothing is.
** Actually, Rotwang is a machinist, and the character is listed as "C.A. Rotwang -- The Inventor" in IMDB. No evidence of a doctorate. However, in the time and place in which the movie was made, "machinist" was a suitable occupation for a stereotypical mad inventor.
** In his native German, Rotwang merely means "red cheek".
* ''Film/PlanetOfTheApes1968'': Dr. Zaius: Ethically questionable... OK, very unethical. In fact, an antagonist. He routinely performs lethal experiments on [[FantasticRacism those inferior humans]], although he later explains ''why'' he's so wary of man.
* ''Film/TheRockyHorrorPictureShow'' Dr. Frank. N. Furter: Okay, so we don't know if he's REALLY a doctor, but he's sure deep into the [[MadScientist Mad Science]]. Not really evil, just hedonistic and petulant.
* Dr. Blight from the Wrestling/HulkHogan vehicle ''Film/SantaWithMuscles''. Likes to spray Lysol cans in a dramatic manner.
* ''Film/SkyCaptainAndTheWorldOfTomorrow''. Dr Totenkopf and his team of {{Reluctant Mad Scientist}}s from Unit 11.
** [[spoiler:Although it is found that he does have a bit of a justification behind his dickery, even if it [[TheEndJustifiesTheMeans involves some atrocities along the way.]]]]
* ''Film/{{Splice}}'' has two scientists that are similar to those in ''Film/{{Species}}'', namely becoming gradually more obsessed with their creation to the point of throwing ethical considerations out of the window and [[spoiler:having sex with it]].
* Doctor Tolian Soran in ''Film/StarTrekGenerations'' was definitely NOT good. In fact he [[spoiler:killed Captain Kirk.]]
* ''Film/ThankYouForSmoking'' has the German scientist doing medical research for the tobacco companies.
-->'''Nick:''' He's been researching tobacco for thirty years and hasn't found any conclusive evidence linking cigarettes and cancer. This guy's a ''genius''. The man could disprove ''gravity''.
* ''Film/{{Transformers}}'': The Doctor. "Ve must hav ze brain on ze table! Chop-chop!" Even his little assistant-bots are designed so that he takes the data they've collected by impaling them to death (a rather inefficient use of resources, you'd think.) When asked what his doctorate is in, he has a tendency to reply with something like 'everything'.
* Dr. Barton in ''Film/NextOfKin1982'' acts in a suspiciously aloof fashion and is evasive of the details of the heroine's past, including information on her unstable aunt Rita who may possibly be the malevolent presence alluded to in her mother's diary.

* Doctor Orwell from ''Literature/ASeriesOfUnfortunateEvents''.
* [[Literature/{{Frankenstein}} Doctor Frankenstein]]: ByronicHero, obsessive to the point of foolhardy.
** Victor Frankenstein is a college dropout in the original book. The title is only given to him in later adaptations (as is the title Baron - his family do not hold a barony, and if they did then the title would belong to his father).
** In the sequels by Creator/DeanKoontz, Victor is indeed a doctor. Also, evil. Also, insane.
* ''Literature/TheScarletLetter'' has Roger [[MeaningfulName Chillingworth]], the inquisitive and respected physician, uses his knowledge of medicine and people to manipulate [[spoiler: Reverend Dimmesdale]] on several occasions to satisfy his own personal paranoia and nosy desires. Made more disturbing when he's shown to be getting an obvious ''pleasure'' from watching his patient and implied personal friend squirm at his instigation.
* Dr Nye, from ''Literature/SkulduggeryPleasant''. A sadistic war criminal who was known for his experiments on prisoners of war. also helps that he's a creepy insect-like humanoid with long, spindly limbs, and visual evidence of once having [[MouthStitchedShut his mouth sewn shut]].
* The Doctor (name not revealed), the illegally-practicing therapist from John Barth's novel ''The End of the Road'': highly intelligent, sometimes very perceptive, but amoral, egotistical, and doesn't seem to be doing any good for his patients. [[spoiler: Accidentally kills one of the main characters by performing an abortion, which he botches.]]
* ''Literature/TheLordOfTheRings'': Saruman fits the trope. His "profession" seems to fit the scientist trope in many respects. He does "research" on the rings, and makes a classical faustian slide into the realm of Evil.
* ''Literature/TheSilenceOfTheLambs'': Dr. Hannibal Lecter [[ImAHumanitarian eats people]], but call him evil and he'll [[WhatIsEvil explain just how small-minded the idea of 'good and evil' is]] and by the end of it you'll agree with him.
* From the Literature/{{Discworld}} are Dr. Cruces, head of the Assassins' Guild [[spoiler: and user of the gonne]] in ''Discworld/MenAtArms''; Dr. Whiteface and the [[MonsterClown intimidating and humourless]] leader of the Fools' Guild. Dr is a non-doctorate academic title.
* ''Literature/SoonIWillBeInvincible'': Doctor Impossible, thanks to his [[ScienceRelatedMemeticDisorder Malign Hypercognition Disorder]]. He's an AntiVillain, but he did get up to doomsday machine mark V.
* Dr Nikola, from the novels by Guy Bootby: Evil, [[AffablyEvil but with a very likable disposition]].
* Dr. Literature/FuManchu from the novels by Sax Rohmer, "with all the cruel cunning of an entire Eastern race, accumulated in one giant intellect, with all the resources of science past and present, with all the resources, if you will, of a wealthy government...the YellowPeril incarnate in one man."
* Dr. Cable of ''Literature/{{Uglies}}'' is a sadistic SuperSoldier. In ''[[Literature/{{Uglies}} Specials]]'' she [[spoiler:starts a war and almost takes over Tally's city.]]
* ''Literature/TheGreatGodPan'': Dr. Raymond is evil or at least extremely callous.
* ''LeMysterieuxDocteurCornelius'': Dr. Cornelius Kramm: VillainWithGoodPublicity.
* Kind of an overarching trope in GenteelInterbellumSetting mysteries, especially those by Christie herself, wherein doctors are very frequently murderers. Several books reference the [[http://en.wikipedia.org/wiki/Hawley_Harvey_Crippen Crippen case]] and other murderous doctors who were in the public consciousness at the time. Additionally, doctors had access to large amounts of barbiturates, giving them the perceived ability to murder by drug overdose and get away with it.
* ''Literature/TheIslandOfDoctorMoreau'': Dr Moreau.
* ''Literature/AHarvestOfWar'': Guinevere Thyll has great medical skill but first and foremost she is a greedy, murderous warrior.
* Dr. Grimesby Roylott, from the SherlockHolmes story "The Adventure of the Speckled Band." [[spoiler: Attempts to use a snake to kill his twin stepdaughters for their inheritance money, succeeding the first time; however, with a little help from Holmes, the snake turns on him before he can succeed again.]]
* ''Literature/GreenSkyTrilogy'': Dr. (D'ol) Wissen was definitely stated to have his hand in some...unpleasant matters, and implied to have his hand in many more including [[spoiler: ordering the murder of his research partner Dr. Neshom]].
* In the afterword of her novel, ''Literature/EvilGenius'', Catherine Jinks said that she got the idea from watching her son playing with figurines of "Action Man" and "Dr. X," which got her wondering where and how supervillains get their degrees.
* ''Literature/GalaxyOfFear'': Doctor Evazam. Bonus points for having the InSeriesNickname "Doctor Death". He actually first appeared in ''Film/ANewHope'', but it was a minor role.
* The titular island-owner of ''Literature/DrFranklinsIsland'' is as amoral as they come--hybridizing animals with human genes, refusing to euthanize the ones that survive the process even if they do so in "very twisted forms", incorporating teenaged human castaways into the project and having them turned into monsters, and playing psychological games all the while. His assistant Doctor Skinner, is... willing to go along with most of it (though he's shaken when he speaks to a rayfish that [[WasOnceAMan was once a girl]]) but can't stand the psychological torment, and alternates ineffectual attempts to help the teens escape with working for his boss as usual.
* Doctor T in ''Literature/ImminentDangerAndHowToFlyStraightIntoIt'' is an alien version of this. He purchases the heroine and her best friend to use as test subjects. On his first day with them, he removes the heroine's brain. Things only get worse from there.
* In ''Literature/ASongOfIceAndFire'', the in-universe [[CallARabbitASmeerp equivalent]] of the title "Doctor" is "Maester", and maesters are usually medical doctors. They are normally pacifists and do no harm. However, one disgraced maester, named Qyburn, was banished from the Citadel (i.e. got his license revoked) for experimenting on live humans and dabbling in necromancy. He served as a field medic in a company of [[PsychoForHire psychos for hire]] and later multiclassed as a spymaster for a [[GodSaveUsFromTheQueen bitch-queen]].
* ''Literature/HeartOfSteel'' gives us Dr. Alistair Mechanus. All we (eventually) know about his education was that he graduated from MIT with a double major in biology and robotics and had a (rather tragic) psychotic break soon afterwards. Apparently the "Doctor" title is self-awarded.
* Dr. Evazan, who appeared in many ''Franchise/StarWars'' ExpandedUniverse sources. (As in, the drunk in the Mos Eisley Cantina who tried to pick a fight with Luke in ''Film/ANewHope'', only to get his ass handed to him by Ben?) Evil criminal MadScientist, and ImmortalitySeeker. Suffice to say that his criminal activities had ''a lot'' to do with why [[EvilMakesYouUgly his face was so scarred.]]
* ''Literature/{{Incompetence}}'' gives us Dr. Rutter, a coroner who removes the faces of cadavers and stitches them onto the buttocks of other cadavers. ''As a hobby''.
* Dr. Jekyll from ''Literature/TheStrangeCaseOfDrJekyllAndMrHyde'', particularly in the original book, where his reason for making the potion was essentially to do bad things and not get caught. His alter-ego, Mr. Hyde, averts this.

[[folder:Live-Action TV]]
* ''Series/{{Smallville}}'' was the king of this trope. The wiki actually had a page on [[http://smallville.wikia.com/wiki/Category:Evil_doctors evil doctors]]! Metropolis University must be the world's leading college for obtaining a Morally Ambiguous Doctorate, because almost every single doctor appearing on the show is either evil or a WellIntentionedExtremist doing unethical experiments ForScience (or, y'know, in return for Luthor money). Even a regular medical doctor [[spoiler: Helen Bryce]] turned out to be evil in Season 3.
* ''Series/MysteryScienceTheater3000'': Doctor Forrester: Evil and goofy.
* ''Series/BuffyTheVampireSlayer'': Doctor Walsh slid from good to misguided to evil in short order before [[spoiler:"being skewered by her own Frankenstein-like creation."]]
** Although he is probably not a true doctor, Doc may be an example.
** Also there was a season 6 villain called "The Doctor" who dealt in transporting violent demons. [[spoiler:It turned out to be Spike.]]
* ''Series/{{Angel}}'''s examples run the gamut from fantastical to the creepily mundane, such as Dr. Meltzer, an eye surgeon with [[DetachmentCombat animatronic limbs]] who stalks one of his patients.
** Though he only appears in one scene, a "Dr. Gregson" is responsible for surgically removing the heart from James in "Heartthrob". This renders James (a vampire who is bent on avenging his lost love) impervious to stake attacks. Gregson uses his medical practice as a cover for his species' custom of collecting rare organs.
** By and large, trusting anyone with a labcoat in Wolfram & Hart is...[[TheMole not a good idea]].
* ''Series/DoctorWho'': The Doctor: Though good, ''Trial of a Time Lord: The Ultimate Foe'' reveals that he has the ''potential'' to become one of the most evil beings in the universe.
** Also, exactly ''what'' the Doctor got his doctorate in is never stated. Some of the earlier episodes seem to indicate that he most likely did ''not'' get his degree in medicine (save for a "purely honorary" degree from working under Dr. Lister [of Listerine fame]), but in law. As an interesting side note, the word "Valeyard" (the name of the Doctor's prosecutor and potential dark side) is said to mean "a doctor of law."
* MirrorUniverse Phlox in the ''Series/StarTrekEnterprise'' episode "In a Mirror, Darkly" where Phlox's role on the ship is still the same, but is now a (still odd and gleeful) sadistic expert of medicinal torture.
** The EMH on the ''Equinox'' on ''Series/StarTrekVoyager''. Since they removed his "ethical subroutines" he's psychopathic. Also, when they removed ''Voyager'''s Doctor's ethical subroutines, he was ready to gleefully remove Seven of Nine's brain. This wouldn't be so bad, but he has a crush on her.
** Dr. Chaotica, the MadScientist villain from ''The Adventures of Captain Proton!'' [[ShowWithinAShow holoprogram]].
* The Evil Doctor in Season 3 of ''Series/{{Beauty and the Beast|1987}}''.
* Doctor Dark, BigBad in the second season of ''Series/WhoWantsToBeASuperhero?''
* ''Series/BattlestarGalactica2003'': Doctor Gaius Baltar. Unwittingly sold out the entire human race to his Cylon girlfriend. [[spoiler: Twice.]] Probably either TrueNeutral or [[GeniusDitz Neutral Stupid]].
* Doctor Mohinder Suresh of ''Series/{{Heroes}}''. A true blue good guy in the first season; evil tendencies started to creep in around the same time he started [[TookALevelInBadass taking levels in badass]] in the second season. A screwed-up recipe for homemade AppliedPhlebotinum resulted in something a FaceHeelTurn, though. The jury is out on whether he's good or evil.
* Dr. Series/{{House}}: Good, but only because he sees deathly ill patients as big puzzles and can't resist "solving" them: saving lives is viewed as collateral damage; he doesn't bat an eye no matter how bleak the prognosis is. Many of his actions when in the process of treating a patient are incredibly unethical, dangerous, unnecessary, or all of the above, and he makes all his choices based on his own selfish whims, but his seemingly evil actions almost invariably lead to a lifesaving cure for someone who would otherwise have been royally screwed.
* Borderline-parodied in ''Series/SabrinaTheTeenageWitch'' "Sabrina the Teenage Writer," with Sabrina's poorly written Bond villain "''Dr. Bad''."
* ''Series/{{UFO}}''. The vaguely sinister Dr. Doug Jackson appears to fill a number of roles in SHADO, ranging from psychiatrist and medical doctor to prosecuting officer. In one episode Commander Straker calls him "the eyes of the International Astrophysical Committee" implying that Dr. Jackson's role is to spy on him for his superiors (which would explain his wide-ranging brief). This is only enhanced by his noticeable Eastern European accent, which would automatically make the 1970's audience think of UsefulNotes/ColdWar EspionageTropes.
* ''Series/{{Lost}}'' has Dr. Juliet Burke (initially on the side of the Others, who have the dubious claim of "the good guys"), Dr. Ethan Rom (seems to have been evil, also part of the aforementioned Others).
* ''Series/{{Fringe}}'': Dr. Bishop, a mad scientist who specializes in bizarre "fringe science" written off by the rest of the scientific community. Probably LawfulNeutral as he seems to be a member of at least one AncientConspiracy.
** He does, however, have some (possibly [[LaserGuidedAmnesia laser guided]]) amnesia. It's possible that recovery of those memories would return him to a cackling evil mad scientist of epic proportions.
** Very, very morally ambiguous indeed. It seems he used to be highly arrogant and not always that concerned about ethics or possible consequences, and that he did do terrible things (including complex drug tests on children). However, it also turns out that most of those terrible things were done with good intentions and that he now feels extremely guilty and tries to atone.
** As for the ''other'' Dr. Bishop, he's a WellIntentionedExtremist, which probably makes him a morally ambiguous doctor as well.
* ''Series/PowerRangersRPM'''s Dr. K, who was raised by Alphabet Soup operatives for weapons research and development. Although she's technically one of the "good guys," in a textbook case of NiceJobBreakingItHero, [[spoiler:one weapon she created in particular--the Venjix computer virus--becomes the season's BigBad after she uploaded the virus to blind Alphabet Soup's security servers in a failed attempt to escape her imprisonment]]. She spends her life afterwards trying to make up for her mistakes.
* On ''Series/{{MASH}}'', Major Frank Burns is a immoral doctor and a ''worse'' officer, likely only gaining the latter position because of the former. (One military judge who looks at his record - when Burns attempts to have Hawkeye court-martialed - claims that if Burns hadn't been drafted as a surgeon he likely would be working as a pastry chef.) In fact, a few episodes have hinted (and given straight admissions from Burns) that he cheated his way through medical school. (Of course, ask any actual member of the military, and he'll comment on how unrealistic ''every'' character in the series was.)
* ''Series/BakuryuuSentaiAbaranger'': Dr. Mikoto Nakadai[=/=]AbareKiller: DrJerk and a White Ranger... but [[{{Jerkass}} NO heart of gold]], and [[LightIsNotGood Evil]]. [[spoiler:He did a HeelFaceTurn in the end though, just in time to [[RedemptionEqualsDeath die]].]]
** Also earlier in ''Series/ChoudenshiBioman'', you don't get much more morally ambiguous when you're a BigBad named ''[[WasOnceAMan Doctor Man]]''.
** ''Series/ChoujuuSentaiLiveman'' had ''five'' villains who qualified as this, with the BigBad being named Great Professor Bias and his human students named Dr. Kemp, Dr. Mazenda, Dr. Obular, and Dr. Ashura. Also, while it isn't in their names, the aliens Guildos and Butchy probably count, as well. [[spoiler:While Bias proves to be irredeemable, Kemp goes insane, and Guildos just dies too early, all of them make Heel Face Turns at some point.]]
* Dr. Reston, Elaine's psychiatrist boyfriend from the ''Series/{{Seinfeld}}'' episode "The Wallet" might count. He seems more interested in [[ManipulativeBastard controlling people than helping them]].
* If you're a doctor in a ''Franchise/KamenRider'' series, you're probably not a nice guy.
** Doctor Shinigami/Ikadevil was one of the main generals of the original ''Series/KamenRider'' series.
** ''Series/KamenRiderDouble'' has Dr. Isaka/Weather Dopant, who actually modified Gaia Memories to kill their users so he could take them and incorporate them and their powers into himself later on, and Dr. Prospect/Eyes Dopant, who performed horrifying experiments on children to turn them into psychics, planned to kill the failed subjects by electrocution, and planted eyes on them to watch them [[spoiler: and kill them if they strayed out of the village]]. Prospect was responsible for the DespairEventHorizon of Katsumi Daido, the antagonist of the first W movie "A-to-Z: Gaia Memories of Fate".
** ''Series/KamenRiderOOO'': Dr. Maki, whose obsession with endings led him to allow a bomber to continue his work and, ultimately, [[spoiler:turn himself into a Greeed and become the Big Bad with the goal of ending everything except himself.]]
** ''Series/KamenRiderGaim'' gives us Ryoma Sengoku, who created all of the [[TransformationTrinket Drivers]] in the show. His ultimate goal is godhood, and he will do anything, including [[spoiler:throwing the world into anarchy]] in order to achieve his goals.
* The titular Doctor of the [[Creator/SidAndMartyKrofftProductions Sid & Marty Krofft]] series ''Dr. Shrinker''. His theme song even states that he's a madman with an evil mind.
* It's been noted on ''Series/TheBigBangTheory'' that Doctor Sheldon Cooper is "one lab accident away from becoming a super villain" (which makes the page quote deliciously ironic). Leonard's mother, Dr. Beverly Hofstadter, can give you the closest thing to MindRape a sitcom grounded in something resembling reality can offer via her questionable usage of her psychiatrist skills. Dr. Amy Farrah Fowler, while usually seeming to be less likely to snap than her boyfriend and [[DistaffCounterpart Spear Counterpart]] Sheldon, has offered to have her lab monkeys kill someone more than once. Dr. Bernadette Rostenkowski-Wolowitz's work for a lab private pharmaceutical company supposedly curing diseases is also implied to be morally ambiguous-which is scary because she's [[StepfordSmiler always smiling]]
-->'''Bernadette''': Oh, I take pacts very seriously. One time at my lab, a petri dish of genetically modified super-virus went missing. That day we made a pinky swear never to admit we crossed Ebola with the common cold.
-->'''Howard''': Why the hell would you cross Ebola with the common cold?
-->'''Bernadette''': We never did. [beat] [[ButThatWouldBeWrong That would be a terrible, terrible thing.]]
* ''Series/BreakingBad'': Walter White [[NotThatKindOfDoctor holds a Ph.D. in chemistry]], which he uses to become the undisputed meth kingpin of the American Southwest.
* [[BigBad Ritter Wulf]] from the Spanish series ''ElInternado'' performed [[WouldHurtAChild horrific, lethal experiments on children during the Holocaust]], and started racial purity experiments [[spoiler:at the Laguna Negra boarding school]]. 60 years later when confronted by [[spoiler:Saúl]], his only regret is not killing more Jews while he still had the chance.
* In ''Series/{{Helix}}'', this is {{Implied|Trope}} of all the research scientists who work at the Arctic Biosystems base. All of them hold the title "Doctor," and come there to take advantage of the opportunity to perform research unencumbered by regulatory agencies. Lead researcher Dr. Hiroshi Hatake openly admits that he encourages his people to "push the envelope."
* Series/NipTuck has a patient in Season 3, who wants to have his leg amputated. His friend went to see a doctor in Mexico, the terrifyingly named Dr. Carrion.
* ''Series/TheFlash2014'' has Dr Harrison Wells who, although he is Barry's mentor in superheroics and thus technically one of the good guys, is rather prone to ShootTheDog actions in order to keep Barry safe. [[spoiler: He's eventually revealed to be the villainous Reverse Flash, zig-zagging this trope a little as it is unknown whether he also has a doctorate in his true identity as Eobard Thawne.]]
* ''Series/H2OJustAddWater'' gives us Dr. Laura Denman, who seemingly thinks nothing of experimenting on unwilling mermaids.

* Several of the supervillains from Music/TomSmith's filk album ''The Last Hero On Earth''.
* Music/TheyMightBeGiants' "Doctor Worm": He's not a real doctor, but he is a real worm, he is an actual worm.
* Music/{{Lordi}}: When "Dr. Sin is In", you want to be out.
* Music/DoctorSteel: No one's sure what he's a doctor of, exactly (he's said he's a Doctor of "Reality Engineering"); but he's bent on taking over the world using an army of robotic toys and brainwashed "toy soldiers" so that he can make the world a better place (for him).
* Disc jockey Creator/DrDemento plays some.. interesting.. songs on his show.
-->"[[Music/NapoleonXIV They're coming to take me away]], uh-huh. They're coming to take me away, ho ho, heehee, haha, to the funny farm, where life is beautiful ''all'' the time and I'll be happy to see those nice young men in their clean white coats and they're '''[[MadnessMantra COMING TO TAKE ME AWAY]] [=HAHAAAAAAAAAAAAAAaaaaaaa=]...'''"
* Doctor X from Music/{{Queensryche}}'s concept album ''Operation: Mindcrime'' has one.

[[folder:Pro Wrestling]]
* [[Wrestling/NationalWrestlingAlliance Championship Wrestling From Florida]] and Georgia Championship Wrestling started being visited by Dr. X in 1969. In Jim Crockett's Mid-Atlantic Championship Wrestling, the evil doctor [[TheGimmick gimmick]] was done away with in favor of [[TagTeam pairing him up]] with Mr. X and calling him Mr. X [[TagTeamTwins #2]].
* Wrestling/DrDeathSteveWilliams. Usually a {{Heel}}, always a badass. He didn't come up with the name himself. He was a champion high school wrestler in Oklahoma during the 1970s, but broke his nose once during a match, and came back wearing a hockey mask the next night, with a local sportswriter calling him "Dr. Death."
* During his heel rapper period, Wrestling/JohnCena proclaimed himself "Doctor of Thuganomics".
* A recurring gimmick in [[Wrestling/{{CMLL}} EMLL]], though few were more [[NamesToRunAwayFromReallyFast immediately obvious]] than El Satánico Film/DrNo, even if he is usually just referred to as El Satánico. More obvious is "El Galeno Del Mal" Dr. Wagner, and his son.
* Formerly known in Memphis as Downtown Bruno, Bruno Lauer arrived in Wrestling/{{WWE}} in 1991 as [[Wrestling/HarveyWippleman Dr. Harvey Wippleman]].
* ''Wrestling/KaijuBigBattel'': Dr. Cube. Evil, trying to take over the world with an army of genetically-modified {{Kaiju}}.
* Wrestling/{{TNA}}: [[Wrestling/StevieRichards Dr. Stevie]]. Evil psychiatrist, has a habit of brainwashing his patients to become his submissive lackeys. Also probably not a real doctor, since his Wrestling/{{ECW}} and Wrestling/{{WWE}} past is mentioned. Better known as Eugene, Wrestling/NickDinsmore has competed for TNA's India partner Ring Ka King as Dr. Nicholas Dinsmore.

* ''Radio/AdventuresInOdyssey'' had the evil Dr. Regis Blackgaard. Not sure what he's a doctor of. When his "good" identical twin brother Edwin came to town he introduces himself as "Mister"; Lucy, mistaking him for Regis, asked if he had to give the title back because he was evil.
* In ''Radio/RoundTheHorne'', a recurring villain was Doctor Chu-En Ginsberg, M. A. (failed).

[[folder:Tabletop Games]]
* From ''TabletopGame/{{Warhammer}} Fantasy'' the Skaven scientists mostly make hideous mutants and terrifying war machines.
** Often at the same time.
* ''TabletopGame/{{Warhammer 40000}}'':
** Fabius Bile, a geneticist who's reduced planets to shambling mutants and created a race of murderous superbeings. In battle he shoots people with syringes that can make them ''explode''. He's also thousands of years old, preserved by BlackMagic pumped into his veins, and doesn't worship any of the [[CosmicHorror Chaos Gods]] despite extensive dealings with them, which may actually be scarier than any of his other accomplishments.
** The Dark Eldar Haemonculi, from whom Bile actually learned his skills. They're functionally immortal {{Mad Scientist}}s that specialise in all kinds of body modifications, from replacing their own blood with acid to turning people into horrible biomechanical abominations. In battle they wield all sorts of freaky weapons, from guns that fire their own acid blood at enemies to syringe-gauntlets that cause the victim to grow out of their skin and caskets filled with invisible fiends that strip the flesh from their victim's bones.
** Ork Mad Doks/Pain Boyz are no more evil, and quite a bit more eccentric than other Orks. Probably ChaoticNeutral if pressed.
* Dr Kholera, from ''TabletopGame/{{Spycraft}}'' fluff: Evil MadScientist. Very evil.
* The TabletopGame/SavageWorlds plot point campaign TabletopGame/NecessaryEvil features Dr. Destruction as the leader of Omega, and includes lesser villains like Dr. Devolution. The entry for the last one lampshades the fact that so many supervillains had doctorates.
* ''TabletopGame/{{Champions}}'' has the master villain Doctor Destroyer, who actually does have multiple earned doctorates (under his real name). Any adventure he's involved in is likely to end up with dead superheroes.
* Given ''TabletopGame/{{RocketAge}}''[='=]s setting there are many scientists who act... questionably, the Nazis in particular.
* Doctor Mordenheim of Lamordia in the ''TabletopGame/{{Ravenloft}}'' campaign, an {{Expy}} of [[Literature/{{Frankenstein}} Victor Frankenstein]]; a FlatEarthAtheist whose experiments in the creation of life were perceived by the gods as blasphemies, and was cursed by them. He's not the Darklord of Lamordia (his monster, Adam, is the Lord) but he shares the same IronicHell.

* [[EveryoneCallsHimBarkeep The Doctor]] from ''Theatre/{{Woyzeck}}''. A bit of a PunchClockVillain, although he also [[KickTheDog defenestrates his cat as a hobby]]. Gets a VillainSong in the rock opera version.
* OlderThanSteam: ''Theatre/DoctorFaustus'':
** Evil. He sells his soul to the Devil, for Knowledge and Power and Helen of Troy. Very MadScientist because Knowledge is one of his goals.
** Or, ambiguous: in some versions, he has his 7 years of Glory, and goes to Hell, ha ha ha, serves him right for being Evil. In some versions, Faust is presented as a sympathetic Character who wants to be redeemed: when he fails, it is tragic Grand Opera, when he succeeds, it is happy ending Light Opera. [[Theatre/{{Faust}} Goethe]] has him as Distracted Neutral if not ChaoticNeutral more than anything else. He sells his soul for knowledge, and most opera versions of Goethe end right after Mephistopheles has done his job by pushing Faust firmly over the MoralEventHorizon. At the end of the second half, after much weirdness, Faust a HeelFaceTurn because he looks around and then gives ''himself'' a WhatTheHellHero speech.
* ''Theatre/ArsenicAndOldLace'': Dr. Einstein: Evil assistant to an AxCrazy serial killer.
* Doctor Miracle from act III of ''The Tales Of Hoffman.'' His plot is to get the sick Antonia to sing herself to death. It takes place in Ancient Greece, so it would've been when the Hippocratic Oath was fairly new.

* Advertisements for the Doctor Dreadful line of toys feature a goofy MadScientist named, well, [[CaptainObvious Doctor Dreadful]]. The line includes the "Doctor Dreadful MD" toys, where the character claims the "MD" stands for [[NotThatKindOfDoctor "Monster Doctor".]] (And in one commercial, he produces a sheepskin to prove he is, indeed, a licensed Monster Doctor.)

[[folder:Video Games]]
* Dr. M from ''VideoGame/Sly3HonorAmongThieves'', who used to be [[spoiler:TheSmartGuy of the gang that Sly's father led]]. The "doctor" part of his name explains why all of his mooks are MixAndMatchCritters.
* ''VideoGame/DeusEx'': Dr Jaime Reyes. Good guy. [[VideoGame/DeusExHumanRevolution Dr. Megan Reed.]] The jury is still out, but evidence heavily suggests she's very amoral.
* ''Franchise/ResidentEvil'': Dr. William Birkin and Dr. Alexia Ashford: The former being a megalomaniacal scientist who starts getting crazy about his research, which causes people to turn into zombies, and eventually causes the outbreak. This makes it okay to shoot him. The latter is another scientist who is also crazy about her designed virus, but also wants to rule the Earth. This also makes it okay to shoot her.
* ''VideoGame/{{Psychonauts}}'': Dr. Loboto, who harvests the brains of young psychic children and [[spoiler: attempts to put them in psychic-powered tanks.]] His [=PhD=] is in dentistry, however, which makes one wonder why [[spoiler: Coach Oleander]] has him working with brains.
* ''VideoGame/HalfLife2'': Dr. Breen, if not evil, then still the willing head of a puppet government.
* ''Franchise/SonicTheHedgehog'' has Doctor Ivo "Eggman" Robotnik: Evil. Nobody has any idea what Ivo's doctorate is in. Probably engineering, if the robots he designs are any indication.
* ''VideoGame/MegaMan'': Dr. Albert W. Wily: Evil, but his creation Zero wound up fighting for the side of good.
** The classic series likes to play with this. Dr. Wily plays it straight, Dr. Cossack subverts it because [[spoiler: he was blackmailed into it by Dr. Wily kidnapping his daughter]], and Dr. Light not only outright inverts it, but he serves as Dr. Wily's good counterpart.
** ''VideoGame/MegaManZero'': Dr. Weil: Waaaay more evil than Wily could ever hope to be. Definitely among the most evil on this list.
* ''VideoGame/FinalFantasyXII'': Doctor Cid: Mad with power. And [[LargeHam very theatrical]].
* ''VideoGame/CallOfDuty'': Doctor Richtofen. Would make [[ThoseWackyNazis Mengele]] cringe.
* ''VideoGame/BrainDead13'': Dr. Neurosis. Evil, but most certainly not [[BerserkButton "average"]].
* Dr. Johannsen (from the video game VideoGame/{{XIII}}). Evil member of the XX conspiracy. Incidentally, arguably a harder boss than the next six bosses or so -- apparently doctors can be total killing machines.
* ''Franchise/CrashBandicoot'': Doctor Neo Cortex: Evil.
* ''VideoGame/CaveStory'': Dr. Fuyuhiko Date: As evil as they come. Master of the PlayerPunch. Actually ''is'' a medical doctor.
* Dr. Baldhead, from ''VideoGame/GuiltyGear'': Evil, murderous, insane; a medical doctor as well. It's implied that he does a HeelFaceTurn later in the series, but when he does, he changes his name to Faust, dropping the Doctor from his name. However, as he still practices medicine, other characters call him [[{{Homage}} "Dr. Faust"]].
** From the SpiritualSuccessor ''VideoGame/BlazBlue''; Dr. Litchi Faye-Ling: Good, compassionate, medical doctor, but corrupted with the Boundary, [[spoiler: and currently amongst the antagonistic NOL, with Hazama around and her morality is in danger whether it will plummet hard to complete evil thanks to Hazama's influence, or she will retain it and consider it a DirtyBusiness to save the one she loved and herself.]]
** Also from ''Blazblue'', Relius Clover. [[ForScience Relius.]] [[MindRape Freaking.]] '''[[AbusiveParents Clover.]]''' While never expliciltly stated to have a doctorate, he is a master of science and alchemy, creating clones and {{Magitek}} weaponry. He's also a complete sociopath willing to torture people [[RapeIsASpecialKindOfEvil in an almost rape-like way]], kill his own wife and daugther to turn their corpses into living weapons, and work with Hazama to try and destroy all reality just to see what happens next. Though strangely, he has no 'Doctor' title, but [[ColonelBadass another]].
* ''VideoGame/CityOfHeroes'': Doctor Vahzilok: [[FrankensteinsMonster Dr Frankenstein]] turned even more [[MadScientist evil and insane]], and with a veritable army of equally evil followers.
* Dr. Kira from ''VideoGame/ArcanaHeart'': Evil, [[ImprobableAge Unusually young to have a doctorate]], a mix between Doctor Evil and [[WesternAnimation/PinkyAndTheBrain Brain]] [[RecycledINSPACE AS A LITTLE GIRL]].
* Dr. Repulsor in ''VideoGame/HeroesOfNewerth'', a grinning goblin obsessed with magnets.
* ''VideoGame/GodHand'': Doctor Ion: Evil [[AIIsACrapshoot as per his programming]].
* In a subversion, MadScientist and BigBad Caulder/Stolos from ''VideoGame/AdvanceWars: Days Of Ruin'' was revealed to have been a doctor, but he doesn't use the prefix -- he was kicked out of the medical academy for ethical violations. He's just THAT evil.
* Played for very dark laughs in ''VideoGame/SouthOfReal''. The KnightTemplar responsible for all the nightmarish experiments in the mansion and the main character's past is, technically, a doctor. That is, he has a doctorate in the arts.
* In addition to being a hilariously over the top SpyFiction game, ''VideoGame/MetalGearSolid'' deals a lot with questions of ethics in extreme situations. As a results, the series has lots of scientists with highly morally ambigous pasts and presents.
** The prime example in the series and for the trope in general would be ''Dr. Naomi Hunter''. She is introduced as the medical advisor for the opperation on Shadow Moses, [[spoiler:but is actually an agent planted by Ocelot. She murdered people, send people who trusted her into ambushe, and handed vital technology over to the enemy. Then she repents and helps snake, disappears from prison, joins Ocelot again and develops weapons for him, and then has the guts to ask Snake to rescue her. Then she becomes Otacons girlfriend and betrays him and Snake by stealing important data for Ocelot, again! She then switches sides again to help Snake a last time and commits suicide.]] And all the time she seems to be genuinely sorry for what she did, but would do the same things again without hesitation. And she never really explains what she is trying to achive.
** ''Para-Medic'' starts as a genuinely nice young physician, but somehow got forced to sign up with the team in [=MGS3=] after the events of the Virtuous Mission, or would have had her license revoked (although she hints that she intended to do the mission anyways). [=MGS4=] later reveals that [[spoiler:she was ''Dr. Clark'', who created the clones of Big Boss and made Grey Fox into the Cyborg Ninja against his will. She got killed by Gray Fox as payback for what she did to him, and partially after EVA/Big Mama told him that she was one of Zero's Patriots and told him to kill her.]]
** Also Otacon is in fact ''Dr. Hal Emmerich''. While a good guy, he was too naive to realize he was building a superweapon, and after going underground with Snake, he frequently broke into high security military computer networks to steal intel and blueprints for Snakes gadgets. Even before meeting Snake, he has done a few instances of hacking into high security networks: One instance was when he hacked the FBI's central database while he was within the Engineering Research Facility branch of the FBI, which got him fired.
** Dr. Emmerich, Hal's father, was similar. Although a good guy, he did work with nuclear weapons and was involved in a project to create a perfect deterrent. Although he was initially willing to work on the project, it was only because he legitimately believed Coldman when he said that it wouldn't be used even once. Unfortunately, Coldman proved his lying/insane nature when he intended to launch a live nuke to test its retaliation abilities.
** Strangelove worked with AI development, and also did torture to Snake, although it is implied that she personally felt disgusted at herself for having to resort to torture. In addition, she intended to create the Mammal Pod so she could revive The Boss, find out what really happened in Operation Snake Eater, and clear her name. Her working to develop the Peace Walker weapon was moreorless a necessary evil she had to put up with in order to do it.
** "Doktor" from ''VideoGame/MetalGearRisingRevengeance'' also displays a rather distressing lack of both regular ethics and medical ethics considering he's supposed to be one of the good guys.
* The Medic of ''VideoGame/TeamFortress2'': Likely a confirmed doctorate, given that most of his team-mates refer to him as "Doctor", "Doc", "Herr Doktor" and the like. Fully aware that healing his team (actually a side-effect of his Medigun) means that they are that much more ''efficient'' at killing the other team. By the way, his bio states he never took the Hippocratic oath. [[RefugeInAudacity And TF Industries still hired him]].
** Whether or not the Medic [[NonIndicativeName has any actual medical training]] is a FlipFlopOfGod. The Medic's old bio states he has no certifiable training or experience (which doesn't mean much as the mercs were not supposed to reveal private info to each other, including each other's real names), while in the 'Meet the Medic" video he casually explains that he actually ''lost'' his medical license due to an [[NoodleIncident incident in which his patient]] [[BodyHorror lost his entire skeleton.]] The worst part? [[BlackComedy He laughs and jokes about it with the Heavy.]]
** The Engineer's backstory says he has [[UpToEleven 11 Ph.D.s]], and he ''seems'' to be a much more stable guy, although that's not saying much considering that the flavor text for ''The Gunslinger'' is that he chopped his own hand off and replaced it with a robot replacement ForScience.
*** There's also the fact that the Engineer's domination voice lines are surprisingly vicious and nasty for someone who cultivates a "Texan nice guy" persona. ("I'm a killer of men, Doc, that's the God-honest truth.") We're talking about a guy who build killer sentry guns for a living and treats them like his children.
** And, if we take ''VideoGame/PokerNightAtTheInventory'' as canon, the Heavy Weapons Guy, of all people, has a [=PhD=] as well (granted, [[NotThatKindOfDoctor it's in Russian Literature, not any of the "hard" sciences]], but still). His morality, like all of the other mercenaries, are strictly team-based, and he's definitely not sane, considering he talks to both his food and his guns as if they're alive in his in-game voice lines.
*** Disproven in the official Valve [=TF2=] comics, in which the Heavy is [[OnlySaneMan one of the most stable]] and [[GeniusBruiser smart members]] of the team. His backstory (in "Meet the Director" and "Cold Day in Hell") clearly shows he works as a merc not because he likes hurting people (although he does not object to it) but to provide money for his elderly mother and three sisters and because of a wish to punish "evil people" (although his definition of evil is pretty utilitarian, "anyone who hurts the people I like").
* [[NamesToRunAwayFromReallyFast Doctor Killjoy]] from ''VideoGame/TheSuffering'', a 1900s level doctor who kills most of his patients in attempts to cure their mental problems. Like Josef Mengele, but British, and he can come back from the dead. EVIL! Still, he apparently has a genuine desire to help Torque with his problems even through extreme means.
* Though never called a doctor outright, you'd have to have a couple doctorates in badass to engineer MULTIPLE plagues which nicely complement each other, as Hakke Dal from ''VideoGame/MakenX'' (Maken Shao on Playstation) so capably demonstrated. Also he shows he has no moral compunction against [[ShootTheDog killing his own daughter]] should you brainjack her to use against him. The reason she was trapped in a psych ward in the first place was because he tested the one of the first prototypes of the Uvad virus on her. He'd likely be [=BFFs=] with Killjoy above in his college days and may have even roomed with him. Also, he's an oddly black man in a game world full of greys. (Though all Hakkes intend to kill a lot of people to forwards their utopia, Dal seems to be the only one enjoying his work. Margaret is just AxCrazy and hopped up on designer drugs like Eugenics and Relativism. BigBad Geist is actually one of the sanest members of the group, as both he and right-hand Yusef can be diplomatically reasoned within a couple endings, provided you made the appropriate storyline choices.)
* ''VideoGame/DeadSpace'': Dr. Mercer, Challus: {{Evil|utionaryBiologist}}, [[MoralEventHorizon evil]], ''[[KnightTemplar evil]]'' bastard. [[MadDoctor Who passed this guy in medical school?]]
* Another Mercer for the list: Dr. Alex Mercer of ''VideoGame/{{Prototype}}'', [[spoiler:The real one]]. Equally evil as Challus.
** Dr. [=McMullen=]: {{Evil|utionaryBiologist}}. Not as much as Mercer, but still evil.
* ''VideoGame/SidMeiersAlphaCentauri'': Dr. Prokhor Zakharov: Not evil, but [[TrueNeutral completely, utterly amoral]].
** Dr. Shen-Ji Yang: LawfulEvil
* Dr. Zomboss, from ''VideoGame/PlantsVsZombies''. He has a doctorate in Thanotonology.
* Surprisingly, even ''VideoGame/WorldOfWarcraft'' has a few of those. Most of them are undead. However, the two who really stand out (both of them evil) are not. Scholomance boss, human, utterly insane, Doctor Theoden Krastinov (doesn't help that his title is "The Butcher"). More badass, gnome Dr. Weavil, obviously a blatant parody of Dr. Evil. He even has a minion called Number Two. No Mini-Me unfortunately...
* [[NamesToRunAwayFromReallyFast Doctor Thrax]] from ''[[VideoGame/CommandAndConquer Command & Conquer: Generals]]'' is quite evil, or at best a religious extremist ''a la'' UsefulNotes/OsamaBinLaden. He wants you to tell stories of your defeat to your three eyed grandchildren. He also wonders if he shouldn't have gotten his degree from a mail-order college. He specializes in bioweapons.
* ''VideoGame/{{Tekken}}'': Dr. Boskonovitch: MadScientist, generally shown somewhat on the side of good (ally of good-guy Yoshimitsu, for one).
** Dr Abel: Evil. What kind of monster tries to blow up an innocent 400lb cybernetic killing machine with no voice? (I'm serious... it's complicated. AIIsACrapshoot, folks.)
* ''VideoGame/{{Borderlands}}'': Dr. Zed: The last person you want near you with anything sharp, but one of the very few people that you can rely on in the DeathWorld that is Pandora. May or may not have somehow been responsible for a ZombieApocalypse.
** And speaking of ZombieApocalypse, Dr. Ned: [[spoiler:[[BossSubtitles Turns out he's a bad guy... who knew?]]]]
** Possibly a subversion, given that Zed doesn't actually have a medical degree and references this frequently (''who needs one when you've got style?''). In [[VideoGame/{{Borderlands2}} the sequel]], he has a rival in Doc Mercy, who, to Zed's frustration, ''does'' have a degree, but is also a bandit and far more concerned with making wounds than treating them.
* Dr. R. Muckly, who you have to rescue from the UsefulNotes/{{Viet|namWar}}congs in ''VideoGame/NAM1975''. [[spoiler:It turns out, in a rather screwy manner, that he is a MadScientist who wants to use a KillSat to take over the world, and so you have to fight him as the game's final boss.]]
* ''Franchise/MassEffect'': Dr. Mordin Solus. Before you actually meet him, all you have is a name and the space station he can be found. As you investigate, everyone tells you that he's crazy and that they don't expect you to survive the encounter, the tales getting more horrid every time.
--> ''"He's not just a doctor. Doctors don't execute people and display their bodies as a warning."''
** When you meet him, he turns out to actually be quite crazy, but seems to be fully aware of what's going on around him and a genuinely nice person. He also seems to be a former member of the salarian [[BadassArmy Special Tasks Group]] and has tech powers to burn people alive.
** And he is also revealed to be one of the leading scientists who [[spoiler:spent some time re-engineering the genophage, an incurable genetic disease that causes massive rates of miscarriages in pregnant krogan to keep the numbers of the species low. He's aware that the bioweapon was ethically reprehensible, but does not regret his actions.]] He mentions that he started the clinic in Omega specifically so that he could do something less morally ambiguous in his twilight years.
*** He then completly redeems himself in ''Mass Effect 3'' by [[spoiler:[[HeroicSacrifice taking the elevator to the top of an exploding weather control tower]] to release the genophage cure over Tuchanka, humming his song from the previous game ''"[[MajorGeneralSong I am the]] [[ScienceHero very model of a scientist Salarian]]..."'']]
** Also, Dr. Saleon. Need spare organs? Grow them in the natural environment of a subject's body!
* Dr. Hojo from ''VideoGame/FinalFantasyVII''. Quite. Crazy. It's hard to find anything he did that is not ForScience. Arguably responsible for ''every single calamity'' that happens in FFVII universe.
** Except Jenova. She fell before he was born. However, he did contribute greatly to making Jenova problem far worse (can you say Sephiroth)?
* ''VideoGame/BioShock1'':
** Dr. Suchong: Absolutely mercenary at nature and willing to commit scientific atrocities as long as he's paid well in the end.
** Dr. Tenenbaum: Created the Little Sisters and initially ambivalent since it's all ForScience. Eventually develops a maternal instinct and becomes TheAtoner.
*** Dr. Steinman: Lethally experimenting on people in order to satisfy his twisted perception of beauty. Evil and [[AxCrazy completely out of his mind]].
** Dr. Lamb from ''VideoGame/BioShock2'' is an Enemy of Free Will and devoted to the destruction of individuality.
** Doctors Powell and Pettifog of ''VideoGame/BioShockInfinite'', who think nothing of strapping Elizabeth into a painful energy siphon, ignoring her heart-wrenching cries for mercy and coldly torturing your sweet, adorable sidekick for ''months'' to break her will. They even privately discuss killing her against the wishes of BigBad Comstock. When Booker shuts down the siphon and Elizabeth gets the chance to ([[DoNotTouchTheFunnelCloud awesomely]]) repay their cruelty, the player will likely scoff in disbelief as they panic and urge Booker to turn the siphon back on.
* Zahra from ''VideoGame/SuikodenTierkreis'', who is always a little ''too'' excited to [[strike:dissect]] examine every non-human specimens in your base.
* Dr. Keith Fetus from ''VideoGame/MeatBoy'' series who is on evil side. In Meat Boy universe, you don't even have to be born to get a university degree.
* Dr. Balfour and Dr. Neis from ''VideoGame/TalesOfTheAbyss'', who between them created [[CloningBlues fomicry]] in the form we currently know it. They split sides into good and evil when Balfour [[spoiler:who had since been adopted by the Curtiss military family and taken their surname]] gave up his research and declared a ban on fomicry, but Neis refused to do the same [[spoiler:and joined the God-Generals so that he'd have the resources to continue]].
* ''VideoGame/LeagueOfLegends'' has Dr. Mundo, The madman of Zaun. As stated in his bio: In his eyes, you are already dead.
* Dr. Venom from the MSX ''VideoGame/{{Gradius}}'' games: Evil.
* ''VideoGame/EarthBound'': Dr. Saturn. Appears to be well-meaning if eccentric. [[http://morganchan.deviantart.com/art/Dr-Saturn-fix-you-up-ding-20827736 Even so...]]
* ''VisualNovel/HatofulBoyfriend'': Dr. Iwamine [[FanNickname "Fat Bird"]] Shuu: Very, very evil.
* ''Franchise/RatchetAndClank'': Dr. Nefarious. As lampshaded by Captain Qwark in ''[[VideoGame/RatchetAndClankFutureACrackInTime A Crack In Time]]''; "In fact, I'm not entirely convinced he's a real doctor!"
* ''[[VideoGame/{{Fallout3}} Fallout 3]]'': In a game filled with sociopaths, Dr. Stanislaus Braun does his best to stand out: As controller and inhabitant of the Vault-112 virtual reality simulations, he has been continually torturing, killing and reviving the other inhabitants of the simulation for 200 years, just to amuse himself. The only reason he enjoys this is ''because they're real people, not just computer programs''; if you MercyKill everyone else there so they can't be revived, he'll act like a spoiled 10-year-old and get upset that you took away his toys. The fact that you've doomed him to being stuck alone in the simulation forever doesn't really register. When you get trapped in Vault 112, he offers to let you leave.... but only if you murder everyone else in the vault for his amusement. He's also the guy who designed most if not all of the other Vaults in the Vault Experiment, which goes a long way to explaining why nearly every Vault descended into madness and horror.
* ''VideoGame/FinalFantasyIV'': Dr. Lugae [[spoiler:turned Edge's parents into chimeras before turning himself into a monster]]. Even [[NobleDemon Rubicante]] [[EvenEvilHasStandards is appalled by this]].
* To help out the construction of the [[Anime/MobileSuitVictoryGundam Angel Halo]] in ''VideoGame/ShinSuperRobotWars'', [[Anime/MazingerZ Dr. Hell]] has already killed several humans in the process of perfecting the technique of creating obedient soldiers, or rather, mutilating them horribly enough [[FateWorseThanDeath that death would be preferable]].
* The BigBad of the ''VideoGame/JamesPond'' series is the evil Dr. Maybe.
* The titular doctor in ''VideoGame/TheCastlesOfDoctorCreep'', if [[MadScientist his]] [[NintendoHard castles]] are anything to go by.
* ''VideoGame/PokemonRanger: Guardian Signs'': [[spoiler:[[BigBad Dr. Edward]], aka "[[PhantomThief Ed the Thinker]]", actually operates as a doctor under the reasoning that when you spend most of your time thinking up evil plots, [[PetTheDog doing a few good deeds]] helps keep some balance in your life.]]
* The enigmatic [[spoiler:[[TheGhost W. D. Gaster]]]] from ''VideoGame/{{Undertale}}'' seems to have one, given the dangerous nature of his creations (like the Core, the [[spoiler:machine that caused the fatal accident]] and [[spoiler:his implied connection to Sans' Gaster Blasters (as they are named in the files)]], as well as the fear certain [=NPCs=] express when discussing him.
* From ''VideoGame/{{Battleborn}}'':
** With a background of having graduated from Archsciences Academy at the young age of 14, Dr. Beatrix Lucavi is an amoral scientist with a penchant for experimenting on living things.
** The moniker used by Thaddeus from the DLC Story Operation "'''Toby's Friendship Raid'''" in the 8th playthrough of the operation is Dr. Garrius Winglehopper. With the title of doctor accompanying it, the name is clearly styled after those of typical evil {{mad scientist}}s and the like. Given Thaddeus' habit of constantly changing his name though, the doctor part is obviously just in name only.
* One of the villains in ''Mystery Trackers 12: Queen of Hearts'' calls himself Doctor Cyanide.
* Dr. Corvine from ''Phantasmat 7: Reign of Shadows'' created a monster that only exists in the dark and can destroy ''ghosts''.
* The villain in ''Arthur Yahtzee: The Curse of Hell's Cheesecake'' is called Dr. Diablo.
* The villain in ''Flight of the Hummingbird'' is called Dr. Sinister.

[[folder:Visual Novels]]

* Dr. Ogai, in ''VisualNovel/SayaNoUta''. He apparently [[spoiler:brought Saya to Earth, and didn't really care if she eventually caused TheEndOfTheWorldAsWeKnowIt. He's the only human being in the story who can see her true form without going mad, and even names her for his deceased cat]].

[[folder:Web Animation]]
* ''WebAnimation/TheLazerCollection'': Doctor Octogonapus: [[BreathWeapon BLAAAAH!!!]]
* ''WebAnimation/SpoilsburyToastBoy'': Dr. Jill, who prescribes [[spoiler:death by drowning]] to cure a stuffy nose.
* Most of the main characters in [[http://bogleech.com/animations.html The Fear Hole]] fall under this category, with some notable highlights including the Turkey Tree (It cures world Hunger! By eating people...), the Nanny bomb (It causes cancer... in pedophiles!), [[spoiler: [[MoralEventHorizon Professor Mellancholly shooting the adorable and childlike Antagonizer in the head]]]] and [[http://www.bogleech.com/flash/FEARHOLE5.html I THINK WE'LL LET THE CROCTOPUS DECIDE]]!
* ''WebAnimation/WebAnimation/DrTran'': ''Here Comes Dr. Tran!''
--> "I am not a doctor!"
--> "He's a ''real doctor!"''
* ''Machinima/TheGmodIdiotBox'' has Dr. Hax, an ArtificialHuman clone of [[VideoGame/HalfLife Dr. Breen]], who ruthlessly destroys all cheaters and hackers by launching monitors and applying the banhammer.

[[folder:Web Comics]]
* ''Webcomic/AnsemRetort'''s Dr. Zexion Doreone: A complete and utter JerkAss who once implanted an Oreo in one of his patients for no apparent reason; the Oreo fused with his DNA somehow, so the patient became half-man, half-cookie. He also planted a firecracker in Riku's liver, fashioned a new heart for Riku out of bendy-straws and a Hot Pocket, and replaced another guy's lung with a monkey's ass. Then there's the fact that during his time as Governor, he's been implicated in 5 sex scandals and 3 murder scandals. The only other person on the cast who likes him is Axel, who happens to be a sociopathic serial killer. Everyone else puts up with him only cause he's part of the cast.
* Doctor Ink of ''Webcomic/DanAndMabsFurryAdventures'': [[http://www.missmab.com/Comics/Vol_525.php His intro comic]] sets the tone for most, if not all, his appearances.
** Even in [[http://www.ariannia.com/ another]] [[http://www.ariannia.com/2008/05/05122008/ freaking]] [[http://www.ariannia.com/2008/06/06022008/ universe]] this guy is [[http://www.ariannia.com/2008/07/07142008/ really]] [[http://www.ariannia.com/2008/10/10032008/ freaking]] [[http://www.ariannia.com/2008/10/10272008/ scary]].
* Doctor Narbon of ''Webcomic/{{Narbonic}}'': Helen is Evil with a capital E. A rare female example; most supervillainous doctors seem to be men. Her clone "Beta" is cute-evil - aspires to evilness and has the reputation and imagery down, but never got around to actually pulling anything off.
** Also she (Beta) isn't a real doctor.
* ''WebComic/EightBitTheater'': Doctor Malpractice: Uh, you figure it out. In the employ of [[EvilChancellor Chancellor Usurper]] no less.
* ''Webcomic/StickManStickMan'': Doctor Max Destruction: a real doctor with a [[http://qntm.org/files/stickmanstickman/comics.php?n=571 degree in astronomy]] (which entitles him to call himself 'Master of Space').
* Dr. X of ''Webcomic/CaseyAndAndy''. Evil. Goal: conquest of all Earth. Managed to conquer [[CheeseEatingSurrenderMonkeys France]] once.
* In-story example in ''Webcomic/QuestionableContent'':
-->'''Jimbo''': Oh man, I gotta write that down. 'Doctor Heteronormative' would be a [=BITCHIN'=] name for the main villain dude.
* ''Webcomic/ElGoonishShive'': Dr. Germahn: Started as Mr Exposition, although the role's been taken by others. Also technically doesn't exist in continuity.
* ''Webcomic/CrossoverWars'': Dr. Catastrophe... although he was a respected scientist before being recruited to be an [[http://eou.comicgenesis.com/ Evil Overlord]]
* ''Webcomic/LastRes0rt'': Dr. Daisy Archanis: Well, at least ''Jason'' thinks she's evil... given that she's accused of / confessed during torture to [[spoiler: taking down the Galaxy Girl Scouts]], he might be onto something.
** Likewise, Dr. Qin Xu IS a vampire... [[DarkIsNotEvil and while that may not be enough]], he's already admitted that he used to snack on his coworkers. So, y'know...
* [[http://luprand.deviantart.com/art/Dr-Luprand-Character-sheet-83829394 Dr. Aloysius Luprand]] seems to exist mainly to torment his roommate, but once in a while the puppy [[http://luprand.deviantart.com/art/Calling-Security-58842496 puts his knowledge to use]]. And then it gets [[http://luprand.deviantart.com/art/Bishounen-Beam-page-1-64605897 creepy]].
* Dr Edward Upton from ''Webcomic/{{Misfile}}'', the protagonistís father. He's a gynecologist who tends to creep out Ash's friends by remembering the details of their... ahem....girl parts.
* ''Webcomic/HannaIsNotABoysName'': Doc Worth hasn't even actually got a doctorate; he dropped out of medical school. He doesn't let that stop him practicing medicine, and he's also terribly shady just generally. Hanna even implies that he [[DepravedBisexual developed a crush on Conrad]] because Conrad [[CombatSadomasochist beat him up]]. And then there's [[spoiler:Hanna's freaking torso, and the "classified" procedure Worth decides Hanna needs after being attacked by a ghost. It seems to be working out all right for Hanna, so, cool, but, also, WTFFF.]]
* Subverted/averted by Nailbat's resident mad scientist, ''Mister'' Simian. This trope is, in fact, lampshaded in the author commentary [[http://www.antibunny.com/d/20081016.html on the page of his first appearance.]]
* ''Webcomic/SluggyFreelance'': Doctor Steve ([[TakeOverTheWorld megalomaniac]], [[{{Brainwashed}} brainwasher]], and CloudCuckooLander), Doctor Crabtree (killing and experimenting on people ForScience), and eventually [[spoiler:Doctor Schlock (coward turned megalomaniac)]].
* ''Webcomic/DrNonami'': Dr. Mechano is an evil madman.
* ''Webcomic/{{Vigil}}'': Myriam seems to be a fairly benign version. She doesn't actually have a degree, due to being kicked out of medical school for failing the [[LackOfEmpathy psychological test]]. And she's learned most of what she knows by robbing graves.
* ''Webcomic/MinionsAtWork'' supervillains include Doctor [[LizardFolk Coldblood]]. Who [[http://www.minionsatwork.com/2009/06/minions-168169-overlord-double-feature.html hates all mammals]]. Well, ''almost'' all.
* ''Webcomic/EverydayHeroes'' features Dr. Unpleasant, Dr. Gene Gromene, Dr. "Dark Anne" Troubled, and maybe more. It's not yet certain whether the BigBad, Doc Tormentor, is an actual doctor or not.
* Dr. Universe from ''Webcomic/{{Spinnerette}}'' - perhaps not evil so much as a WildCard, but with a definite tendency to the terrifyingly... pragmatic.
* Chastopher from ''{{Webcomic/Zoophobia}}'' is the Z.P. Academy's nurse, despite being, [[http://zoophobiacomic.com/?p=448 well...]]
* In ''Webcomic/CuantaVida'', the Blue Doctor is insane and many of his teammates don't want to get treatment from him or people will fetch his patients after the procedure to keep the doctor from performing "extra tests". [[spoiler: He kills Liam and tries to kill Jeremy for being crippled and, in his opinion, useless. If he kills them, they would have been replaced.]]
* ''{{Webcomic/Homestuck}}'''s [[ManipulativeBastard Doc]] [[{{Satan}} Scratch]] is an [[FauxAffablyEvil excellent]] [[DevourTheDragon host]].
* Played with in [[http://www.shortpacked.com/2009/comic/book-9/09-grand-reopening/johnnywitts/ this]] episode of ''Webcomic/{{Shortpacked}}''.
* Marissa from ''Webcomic/SturgeonsLaw'' has one, as she insists on pointing out at every [[http://sturgeonslaw.net/comic/37-mathematicals/ opportunity]].
* ''Webcomic/{{Follower}}'': Dr. Tolio. His character bio mentions [[NoodleIncident an incident]] that ended with him being offered the choice between working for the FBI or life imprisonment. He also seems fully supportive of using the Chio as [[SuperSoldier super soldiers]].
* ''Webcomic/GirlGenius'': Almost any Doctor introduced. Hell, almost anybody introduced, often played with for laughs.
* [[MadScientist Dr. Hayter]] and the [[ReligionOfEvil Ixzerite]] doctor at the Walnut Grove Health Center Victor's mom took him to see from ''Webcomic/CharbyTheVampirate''.
%%* ''Wecomic/TwoGuysAndGuy'': Frank. Frank fits this to a T in some strips.

[[folder:Web Original]]
* The rather ironically-named Dietrich "Medic" Luzweit in ''Roleplay/DinoAttackRPG'' would certainly qualify, being an unstable doctor who nearly lost his medical license after somehow removing a patient's skeleton. The only thing that kept him in action was the fact that [[ItMakesSenseInContext a mutant dinosaur apocalypse had just started]] and there was a desperate need for people with medical training. Averted by just about every ''other'' [[TheMedic medic]] in the RPG, though.
* The facility in which the entire story of ''Roleplay/RubyQuest'' takes place in, known as The Metal Glen, was--in a nutshell--built out of an odd, isolated, geological-formation from out in the middle of a secluded loch [[spoiler:for the specific purpose of doctors and medical researchers practicing/ testing treatments[[note]](treatments that would likely be deemed as "unconventional" by most)[[/note]] without the need of the proper permits, license, or the possibility of criminal prosecution.]]
* ''WebVideo/{{lonelygirl15}}'': Dr. Calvin Hart: Debatably good, but fairly creepy.
* ''WebVideo/DoctorHorriblesSingAlongBlog'': Dr. Horrible repeatedly informs us he has [[CatchPhrase "a Ph.D. in Horribleness"]], even though he is a TechnicalPacifist who pretty steadfastly refuses to endanger children and balks at killing.
** At least until [[spoiler: Penny dies, at which point he starts playing this trope ''dead straight''.]]
*** Actually, this trope is deconstructed: He only becomes evil because Captain Hammer thinks all smart and nerdy guys are evil, and thusly treated him as a villain even when he was not yet one, so he became a villain because he was seen as a one anyway. And he is still [[BlackAndGreyMorality better than Captain Hammer]]
* ''WebVideo/LG15TheResistance'': Dr. Leonard J. Alderman: Evil.
* Dr. Insano of ''WebVideo/TheSpoonyExperiment'', nemesis of Linkara and alter ego of [[spoiler: Spoony.]] His running mate is Fu Manchu.
** And he wants to take the world (of course!)... WITH SCIENCE!!!!
*** Dr. Insano's brother, Dr. Linksano of ''WebVideo/AtopTheFourthWall'', has now been created due to a crossing of parallel dimensions brought on by Dr. Insano during the Spoony-Linkara review of ''Warrior #1.'' The sequel to said review introduces the Insano equivalents of several Website/ThatGuyWithTheGlasses regulars, including WebVideo/TheNostalgiaCritic, Film Brain, and...Beary (who uses a mind-controlled Benzaie to get around).
* ''WebVideo/KateModern'': Dr. William Griffin: Good, but [[HeelFaceTurn formerly evil]].
** Dr. Reece and Dr. Kavorkian: Presumably evil, but [[HarmlessVillain harmless]].
* ''Machinima/RedVsBlue'': The Director of Project Freelancer, Doctor [[spoiler:[[MeaningfulName Leonard Church]].]]
* [[http://www.youtube.com/watch?v=FO0kRE5OTZI Dr. Tran.]] Not only is he a REAL DOCTOR (from AMERICA), he's a dashing secret agent with a [=PhD=] in '''KICKING YOUR ASS!'''
* In the ''Roleplay/GlobalGuardiansPBEMUniverse'', no one is really sure what specific areas Doctor Heinrich Frankenstein, Doctor Phillipe Moreau, Doctor Blight, Doctor Sinister, Doctor Emilio Astonishing, Doctor XX, Doctor Devastation, Professor Sunday, Professor Septimus, Professor Penelope Periwinkle, and Doctor Gavin von Leggend (all villainous {{Mad Scientist}}s) hold their degrees in.
* ''Wiki/SCPFoundation''
** SCP-231 is a woman who can only be attended by medical personnel who haven't taken the Hippocratic Oath. Why? Because she has to be permanently strapped to a hospital bed, and once daily she has to be subjected to a medical procedure so horrific that most of the details can't be disclosed or else she gives birth to...''something'' which could cause untold death and destruction.
** Dr. Wondertainment, a person or organization dedicated to creating [[MyLittlePanzer ridiculously dangerous toys]] and distributing them among children. Apparently more oblivious than evil.
* Doctor Mother from {{Literature/Worm}}, who manages to have ''two'' NamesToRunAwayFromReallyFast.
* ''WebAnimation/YouTubePoop'': Doctor Rabbit: Evil as sin. Also, he is an actual doctor. Well, a dentist, but still...
* Seems to be a requirement for the [[Podcast/WelcomeToNightVale Night Vale]] Medical Association.

[[folder:Western Animation]]
* Professor Chromedome from ''WesternAnimation/TheTick'' is not only proud of being this, but he also calls out some other mad scientists at a convention for [[CrowningMomentOfFunny not being morally ambiguous enough]]!
--> '''Chromedome:''' Bah! More varm fuzzy nice-nice! Vot good is science if no one gets hurt?! You should all be ashamed of yourselves!!! Vat vith your vorld peace und your moccasin valking und your potpourri! You are not mad scientists; '''you are a bunch of hippies!!!'''
* ''WesternAnimation/CaptainPlanetAndThePlaneteers'': Doctor Blight: Usually evil for the cash, the looks, or the fame, sometimes evil for the sake of being so.
** Duke Nukem also had a doctorate of some ill-defined sort. It's implied [[ProfessorGuineaPig he's a walking radioactive rock because of his experiments]], and Kwame calls him Dr. Duke Nukem once or twice.
* ''WesternAnimation/KimPossible'': Doctor Drakken: Evil, but [[HarmlessVillain not especially dangerous]]. Not surprising given that he was a college dropout and therefore possesses no degree.
** [[NamesToRunAwayFromReallyFast Professor Dementor]]. Somewhat more competent than Drakken, who would rather steal his inventions than invent his own.
* ''WesternAnimation/TheVentureBrothers'':
** Doctor Venture: Kinda Good. He isn't plotting world domination or looking for [[KickTheDog dogs to kick]], but he is a bitter grouch at the center of a SadistShow. And he did once build a wish-fulfillment machine that was [[PoweredByAForsakenChild powered by the heart of an orphan]]. ...and then there was the bit with reanimating the corpses of his enemies (and implied killing of the cloned bodies of his children) and selling them to the army. He isn't actually a doctor.
** Dr. Byron Orpheus: Good, but obnoxious and [[LargeHam overbearing]], and not above mind-wiping his own daughter repeatedly so she'll forget that her closet is the doorway to the underworld. He has a degree in Women's Studies, but accredits his Doctorate to a higher power.
** The Phantom Limb was a professor before his lab-accident-powered FaceHeelTurn, and likely had a doctorate.
** Dr. Girlfriend/Dr. Mrs. The Monarch: Not only evil, but better at it than the Monarch himself. She acts as a moderating force on him, but if you assume that means she's secretly good you are sadly mistaken. It is later revealed her Doctorate is Honorary from donating money to an [[AcademyOfEvil Evil College]].
* ''WesternAnimation/AquaTeenHungerForce'': Doctor Weird: Utterly insane. The same could just as easily be said for Doctor Wongburger.
* ''WesternAnimation/JonnyQuest'': Dr. Zin: Evil.
* ''InspectorGadget'': Doctor Claw: Evil.
* ''WesternAnimation/PhineasAndFerb'' Dr. Doofenshmirtz: Evil, yet incompetent. Seriously, he makes Drakken look like Victor Von Doom. He's always beaten by a ''platypus'' for crying out loud! He isn't actually a doctor, he just uses the title. [[MadScientistsBeautifulDaughter His own daughter]] pointed out that his diploma was fake.
--> '''Doofenshmirtz:''' Soon, the world will tremble before the might of [[LargeHam Doctor Heinz Doofenshmirtz!]]
--> '''Vanessa:''' Doctor? Since when are you a ''doctor''?
--> '''Doofenshmirtz: *shows diploma*''' They don't give these out to just ''anyone'', you know.
--> '''Vanessa *reveals price tag*''' Anyone with fifteen bucks, they do.
--> '''Doofenshmirtz:''' That's enough looking!
* ''WesternAnimation/TheSimpsons'':
** Dr. Nick Riviera, aka "Dr. Nick" on Not truly evil, but clearly missing a few marbles, something his patients often suffer as a result of. He actually went to medical school (proven by a flashback) but it isn't known if he actually graduated, and while he practices medicine, he uses controversial and often illegal methods. To give some examples, in one episode a hospital review board brings up the accusations against him which include performing surgery with a knife and fork from a seafood restaurant and misuse of cadavers (he had put them in his car in order to use the carpool lane and get to work quicker). In another episode, he is asked to talk to the coroner, and he says, "Ugh, the coroner. I'm so ''sick'' of that guy!" suggesting his patients get sent there rather often. (Ironically, this is the episode where Nick does Homer's double bypass surgery, and Nick actually does it right, but Lisa helps him a little.)
--> '''Dr. Nick:''' Well if isn't my old friend, Mister [=McGreg=]! With a leg for an arm and an arm for a leg!
** Dr. Julius Hibbert, post-{{Flanderization}}, can also qualify as being weaselly, up to the point where you may argue he's sort of evil. Originally, Hibbert was one of the few competent people in Springfield and often played the role of OnlySaneMan, but Hibbert eventually became a doctor who seems to spend more time finding ways to have his patients sign away their right to sue before the inevitable malpractice issue than actually being a quality doctor. And he also profitted heavily when all companies in Springfield eliminated their health care programs, forcing people to pay at a premium. Likely his most immoral action (by the standards of RealLife medicine) was approving of an obviously unhealthy eating contest (as it was in a restaurant he held half-ownership of) where one contestant actually died of beef poisoning, and then claiming it [[BlatantLies was caused by another restaurant]]. A BaitAndSwitch gag implies that he's been practicing medicine without a licence, as he's shown gulping nervously when Bart and Lisa start putting out the town's secrets over the radio, but ultimately finger Homer.
** "The Man Who Grew Too Much" reveals that Sideshow Bob has a Ph.D, and uses it to genetically enhance his own DNA, giving himself animal-themed super-powers.
* ''WesternAnimation/{{Gargoyles}}:'' Doctor Anton Sevarius: Evil for cash. Also voiced by ''[[Creator/TimCurry Tim freaking Curry]]''.
* ''WesternAnimation/SouthPark'': Professor Chaos: Evil, but harmless. Not actually a professor, but rather Butters wearing tinfoil.
* ''WesternAnimation/{{Futurama}}'':
** Professor Hubert Farnsworth: Senile to the point of insanity, but mostly harmless. Has a penchant for creating doomsday devices, only keeps Amy around because she's his blood type, tries to harvest Leela's organs, is implied to be a cannibal, implanted Hitler's brain in the body of a shark, [[ItMakesSenseInContext killed people for their stem cells]], has been frequently cited for public nudity, and frequently, knowingly sends his crew on life-threatening adventures without warning, to the point of hiring replacements even before their demises are confirmed. In his youth, he created the modern robot, an ecological disaster. Opposed the legalization of {{Robosexual}} marriages, but eventually changed his mind.
** Averted by Amy Wong, who was finally awarded her doctorate in Season Six. Somewhat ditzy, but generally good.
* Herr Doktor from ''WesternAnimation/ReBoot''. Obediently Evil. Whenever Megabyte needs to have something nasty done to a prisoner, this is the binome for the job.
* Dr Fossil, a one-time villain from ''WesternAnimation/DarkwingDuck'': Evil.
** [[TheUnseen Dr Slug]]: So evil you wouldn't believe.
** Dr. Reginald Bushroot: Evil, if a bit of a {{Woobie}}. (And the reason he turned evil was because of his two {{Jerkass}} co-workers, Dr. Larson and Dr. Gary.)
* ''StreetSharks'': Doctor Paradigm: Crazy but his experiments [[AwesomeButImpractical don't always make much sense]]. Is obsessed with [[LegoGenetics gene-slamming]] everyone and anyone he can get a hold of. Then there's Doctor Bolton, who's a really nice guy but [[DisappearedDad is forced to go into hiding]] for most of the series, after [[PlayingWithSyringes getting an injection]] and experiencing some BodyHorror.
* {{Music/Gorillaz}} bassist Murdoc Niccals earned a doctorate from an Open University course when in jail in Mexico. He claims he is now "legally entitled to experiment on monkeys".
* ''WesternAnimation/StarWarsTheCloneWars'': Dr. Nuvo Vindi: Crazy and Evil.
* ''WesternAnimation/JimmyTwoShoes'': Dr. Scientist: Well, it is [[CrapsackWorld Miseryville]].
* ''WesternAnimation/{{Doug}}'': Smash Adams nemesis Dr. Decay.
* ''WesternAnimation/AdventuresOfTheGalaxyRangers'': Dr. Owen Negata of BETA. Casually talking about using a teenaged boy as a control for a genetic experiment will land you here. Funny thing, he's considered one of the ''good'' guys. [=GR=] could be a real WorldHalfEmpty.
* ''WesternAnimation/{{Archer}}'': Dr. Algernop Krieger. Batshit insane and possibly a [[Literature/TheBoysFromBrazil clone]] of UsefulNotes/AdolfHitler ([[spoiler:Nope. [[CaptainObvious The fact that he looks nothing like Hitler was the first clue]]]]. Once mentioned that he is NotThatKindOfDoctor and, technically, not the other kind of doctor.
* Dr. Five Eyes from ''WesternAnimation/SkysurferStrikeForce''.
* Clearly referenced in the ''WesternAnimation/{{Arthur}}'' episode "Elwood City Turns 100!" When the class is being handed their roles in the town's centennial play, Buster misreads "Director" as "Dr. Ector" and immediately assumes he's the villain. And has a claw. [[spoiler:When Buster later makes a surprise appearance on stage as an alien named Dr. Ector, he's not villainous, just oddly obsessed with dental hygiene. ItMakesSenseInContext.]]
** Parodied in the "Dark Bunny" TV show. His arch-enemy is the "Doctapus," an octopus who apparently went to college and earned a doctorate.
* ''WesternAnimation/ChallengeOfTheGoBots'' had Dr. Braxis, a MadScientist who allied with the Renegade Go-Bots. In the pilot mini-series, Dr. Braxis figured out a way to control human minds worldwide.
* Not to be outdone, the ''[[WesternAnimation/TheTransformers Transformers Generation 1]]'' cartoon 3-parter "The Ultimate Doom" had Doctor Arkeville[[note]]Sometimes misspelled "Dr. Archeville," so as to read more like "arch-villain"[[/note]], the self-proclaimed evil genius who assisted the Decepticons in developing a microchip that could control human minds.
* Speaking of ''Transformers'', ''[[WesternAnimation/TransformersRescueBots Rescue Bots]]'' features the amoral, scheming, self-aggrandizing Doctor Thaddeus Morocco, voiced by Creator/TimCurry.
* ''WesternAnimation/TheSmurfs'' has Dr. Charlatan, who is really a SnakeOilSalesman.
* In the ''WesternAnimation/JusticeLeague'' episode "[[Recap/{{JusticeLeagueS2E5And6OnlyADream}} Only a Dream]]", a DreamWeaver calling himself Dr. Destiny goes after the League. He gave himself the title; it wasn't granted by an authority.
* The witch doctor [[PunnyName Dr. I.C. Spots]] from the ''WesternAnimation/LooneyTunes'' short "Which is Witch" is LaughablyEvil.
* Professor Evil Professor from the ''WesternAnimation/PennZeroPartTimeHero'' episode "I'm Still Super!" has an actual [=PhD=] in Villainy.
* Dr Screwball Jones from ''WesternAnimation/WanderOverYonder'' has an online [=PhD=] in cartoonish supervillainy, and does not take lightly to having his title ignored.
-->'''Wander:''' Screwball, you try too hard!\\
'''Dr Screwball Jones:''' ''Doctor'' Screwball, if you please!\\
I've got an online [=PhD=]!