->''"You're gonna feel a little pinch, maybe some discomfort around the neck area. But don't worry. When you wake up, you'll have the body of a seventeen-year-old. In fact, you'll have the body of several."''
-->-- '''Series/BuffyTheVampireSlayer''', "Some Assembly Required"

This is an ArtificialHuman, usually but not always a clone, who is created from the combined DNA of multiple individuals. Sometimes the intent was to clone a single individual exactly, but extra genetic samples were added to the mix by accident. Other times, this is done on purpose to give the clone [[AllYourPowersCombined specific traits from each genetic donor]].

Non-clone Mix-and-Match Men are [[FrankensteinsMonster physically built from parts of other people, literally stitched together.]]

Can be {{Half Human Hybrid}}s when at least one genetic donor is human and at least one isn't. Can be MixAndMatchCritters when all genetic donors are non-humans, such as HumanAliens. Obviously more likely to occur in settings where DesignerBabies are common. LegoGenetics are a prerequisite for making these out of vastly different species. PatchworkKids is when an individual produced by ''normal'' reproduction might as well be one of these, and ExtraParentConception is a variation of this trope where this occurs as part of a normal conception (or as normal as it gets for that particular species).



[[folder:Anime & Manga]]
* Cell from ''{{Dragonball}} Z''. As the name suggests, he was created from the DNA of the strongest fighters to ever set foot on Earth. Which gives him the best traits of [[HumansAreWarriors humans]], [[HealingFactor Namekians]], [[CameBackStrong Saiyans]], and... [[NoNameGiven whatever Freeza's race is called]].
* Giorno Giovanna from ''Manga/JoJosBizarreAdventure''. While he's not a clone of anyone in particular, the [[GrandTheftMe strange circumstances]] around his conception gave him characteristics of both Jonathan Joestar and Dio Brando. This is reflected in his name: [=JoJo + Dio = GioGio=]. Turns out there's three other men created from these same circumstances, they appear in Part 6.
* ''Anime/TenchiMuyo'''s Ryoko was made by [[spoiler:Washu, then a genetic researcher for the Jurai, hoping to create the daughter she could never have (and that could never be taken away from her like her son had been, sadly it did ''[[TearJerker not]]'' work out that way), mixed her own genes with genes from a microbe she'd been studying]].
** In the film, ''Daughter of Darkness'', the BigBad creates an artificial daughter for Tenchi using DNA from his hair and one of her own.
* In ''Manga/{{Appleseed}}'', the [[ArtificialHuman Bioroids]] were created with DNA from several donors, including the father of heroine Deunan.
* ''Anime/NeonGenesisEvangelion'': Rei is formed from the DNA of [[spoiler:Yui Ikari and the angel Lilith]].
* In ''Manga/UQHolder'', [[spoiler: Touta Konoe]] is strongly implied to be one of these, being the result of a genetic experiment meant to combine [[spoiler: Negi Springfield's enormous magical power with Asuna's AntiMagic]].

* It's implied that The ComicBook/{{New 52}} version of ''Comicbook/{{Superboy}}'' isn't just Kryptonian and human, but a ''mix'' of other alien species.
** According to Harvest in #19 [[spoiler: he's "the product of three unique genetic strands". Two of these are Superman and Lois Lane. The third being the son of an alternate Clark and Lois.]]
** In the previous continuity, he was a mix of Superman and Lex Luthor. This was decidedly ''not'' the original intention, but when a fan named Creator/GeoffJohns [[RunningTheAsylum became the book's writer]]...
* ComicBook/{{Deadpool}} probably counts, but he was a normal human before the Mix-and-Match.
* Damage is somewhere between this trope and DesignerBabies; his genes were taken from all the original ComicBook/JusticeSocietyOfAmerica.
* UsefulNotes/{{The Silver Age|of Comic Books}} Creator/DCComics hero ''Ultra, The Multi-Alien'' was a man (in the future) who was a victim of four alien criminals trying to create a means to replicate armies of themselves to conquer the universe. He ended up with a freaky composite body and each of the aliens' powers, which he then used to become a superhero. (He later finds a way to switch back-and-forth between human and multi-form.)
* Brianna from Fred Perry's ''ComicBook/GoldDigger'' was created with the traits and [[GeneticMemory memories]] of her two "sisters" in a FreakLabAccident.
* [[Creator/DCComics DC's]] Composite Superman. Depending which version you're talking about, he has the combined powers of Supes/Bats plus some JLA folks, or the combined powers of a buttload of ComicBook/{{Legion of Super-Heroes}} members.
* ComicBook/{{X 23}} is a relatively mild case of this, being primarily an OppositeSexClone of {{Comicbook/Wolverine}}, but because the DNA sample used was damaged they had to double up on the X chromosome, resulting in her being female. Some stories also try to HandWave Laura's resemblance to Dr. Sarah Kinney, the woman who carried her to term but was otherwise not related to her, by saying that Sarah used some of her own DNA in the stabilization process, which would give Laura genetic parents in the form of Logan's mother and father and Sarah. Regardless of whether this is indeed the case, because Sarah carried Laura to term, Laura ''does'' have Sarah's mitochondrial DNA.

* Creator/ArnoldSchwarzenegger and Danny [=DeVito=]'s characters from ''Film/{{Twins}}'' are DesignerBabies with combined DNA from six athlete and scholarly fathers.
* The version of {{Deadpool}} used in ''Film/XMenOriginsWolverine'' fits the trope even more so than his comics counterpart, having Wolverine's [[HealingFactor regeneration]], adamantium skeleton, and [[KatanasAreJustBetter adamantium katanas protruding from each wrist]], in addition to Cyclops's [[EyeBeams eye-beams]], Kestrel's {{teleportation}}, and his own superhuman hand-eye-coordination.
* Sid 6.7 from ''Film/{{Virtuosity}}'' is sort of like this - he was a computer program created from the personalities of 183 criminals ([[ArsonMurderAndJaywalking and an orchestra director]]), which tricked a programmer into placing him in an android body so he could do damage in the real world.
* In ''Film/{{Frankenstein|1931}}'', the monster is made up of various spare parts. The [[Film/{{Frankenstein 2004}} Dean Koontz version]] goes so far as to identify what sort of people his parts came from. The [[Literature/{{Frankenstein}} novel]] gives almost ''no'' details about its creation.
* Creator/MelBrooks ''Film/YoungFrankenstein'': like the original Frankenstein's Monster, he's built of parts from corpses.
* The protagonist of Cronenberg's ''Film/TheFly1986'' kidnapped his pregnant love interest in an attempt to merge himself, her, and their unborn child into this trope. It's unclear if this could possibly have worked, but at the time he was so desperate to suppress his transformation into a human/fly hybrid that he wasn't thinking straight.
* In ''Film/TheFlyII'', Seth's child has grown up, and [[spoiler: reverses his own transformation by using his father's teleporter to ''steal'' human genetic material from the CorruptCorporateExecutive who'd raised him as an unwitting laboratory experiment, replacing his hereditary fly genes with human ones.]]
* "Lazarus" from the 1995 [[Creator/{{Syfy}} Sci-Fi Channel]] movie ''Mr. Stitch'' is a sort of Frankenstein Monster made from the corpses of eighty-eight people of every race, age and lifestyle, split evenly among gender and given an identity of his own. Things go wrong when it turns out he has GeneticMemory.
* The reason why the title villain in ''Film/MonsterMan'' is killing and amputating people is because he needs bodyparts to patch up his resurrected brother.
* The creations in ''Scream and Scream Again'' seem to fit this trope.
* The BigBad of ''Film/BattleBeyondTheStars'', Sador of the Malmori, plans to live forever this way, using his torture-surgeon to sever limbs of enemies or incompetent henchman.
-->'''Kalo:''' Remember Bilko? He disobeyed orders, and now Lord Sador's wearing his foot.

* In ''Literature/{{Animorphs}}'', Ax's human form is one of these. He took DNA from four of the other Animorphs to create his human form, so he wouldn't look like a copy of anybody.
** Specifically, two boys and two girls, creating a result that is regularly described as "[[{{Bishonen}} disturbingly pretty]]".
* The ''Literature/{{Replica}}'' series of novels has one of these as the main character, created deliberately to be an {{Ubermensch}}.
* The title character of Creator/RobertAHeinlein's ''Literature/{{Friday}}''.
** Same author, the character of Minerva in ''Literature/TimeEnoughForLove''.
** Also Minerva's twin sister, Pallas Athena, who finally gets a body with the exact same DNA as Minerva in Heinlein's novel ''Literature/ToSailBeyondTheSunset''.
* Darci, the protagonist of the sci fi novel ''Star Split'', is eventually revealed to be a chimera, or someone made of multiple strands of DNA. This itself isn't unusual in the far future world where genetic engineering is the norm, but she's a special case.
%%* Damsel in ''Literature/SoonIWillBeInvincible''.
* In Creator/VondaNMcIntyre's sci-fi novella ''Screwtop'', one of the inmates of a prison camp is a mixed-race human "tetraparental", which means his genes have been spliced together from four parents, resulting in black-and-beige marbled skin and patches of black and blond hair of different textures.
* In Donald Moffitt's ''Genesis'' series, all humans created by the Nar use this as their preferred reproductive method, as the human gene pool is still too limited to allow random breeding.
* Flinx from Creator/AlanDeanFoster's Humanx series was conceived via this trope by criminal scientists, who spliced together DNA from dozens of psychically-inclined sources.
* The Igors on Literature/{{Discworld}} typically have parts from multiple people, and can replace someone else's missing parts as well. (There is also a mention of a Mix-and-Match ''Horse'' in ''Discworld/GoingPostal'', as well as Thcrapth the dog from ''Discworld/CarpeJugulum'' and Patcheth the cat in the 2015 ''Discworld Diary''.)
* Invoked from an alien POV in ''Literature/PerdidoStreetStation'', when an insect-headed khepri describes humans as "khepri bodies with the heads of shaved apes".
* Creator/StanislawLem's ''Przekładaniec'' explores this: in traffic accidents, doctors aim to save as many lives as possible, even if this results in having to mix working part of people (or even animals).
* The title character of Larry Niven's The Patchwork Girl qualifies as the second type. The widespread use of organ banks (and capital punishment by disassembly for them) in the Known Space setting results in many people technically fitting this trope to some extent. [[spoiler: She gets that way by being reassembled from the organ banks after first being partly disassembled for those same banks after being framed for a murder. The protagonist clears her, but is too late to prevent her disassembly due to an emergency need for organs.]]

[[folder:Live Action TV]]
* Adam from Season 4 of ''Series/BuffyTheVampireSlayer'' was an amalgam of most of the monsters that the Initiative had captured and was taken out by an amalgam of the main characters.
* The Vidians on ''Series/StarTrekVoyager'' are a race of these. A plague has swept through their entire species, forcing them to cannibalize parts from other aliens. The disease adapts so quickly that the Vidians can never stop looking for new parts.
%%* Luke Smith in ''Series/TheSarahJaneAdventures''.
* ''Series/DoctorWho'':
** [[Recap/DoctorWhoS13E5TheBrainOfMorbius Morbius's]] second body, being a tribute to [[Literature/{{Frankenstein}} Frankenstein's monster.]]
** "Handy" / the Metacrisis Doctor, a Tenth Doctor clone with some of Donna's DNA.
** "Auntie" and "Uncle" from "[[Recap/DoctorWhoS32E4TheDoctorsWife The Doctor's Wife]]" are kept alive with parts from murdered Time Lords.
* Max from ''Series/DarkAngel''.
* It's implied that [[Series/StarTrekTheOriginalSeries Mr. Spock]] was conceived in this way. The ExpandedUniverse novels outright say he was, but as always, there are {{canon}} issues with those.
** ''Series/StarTrekEnterprise'' had baby Elizabeth, created from human and Vulcan DNA with a fatal flaw deliberately introduced by a [[FantasticRacism hate group]] to make her a StrawLoser of a particularly heartbreaking kind.
* Series/{{House}} had a patient like this. A boy had a few groups of cells throughout his body that were the result of two fertilized eggs fusing together immediately after fusing to the uterine wall.
* In the third season of ''Series/{{Haven}}'', Audrey suspects that the Bolt Gun Killer is collecting his victims' body parts in order to build a Mix-And-Match Woman. [[spoiler:The killer is actually a {{Skinwalker}} and building a customized suit.]]
* ''Series/PowerRangersDinoCharge'' has Curio, who was created from spare monster parts to be friends with Poisandra.

* Appropriately enough, the Creature in Creator/SegaPinball's ''Pinball/MaryShelleysFrankenstein'' is this, complete with big, visible scars.

[[folder:Tabletop Games]]
* In ''TabletopGame/PrometheanTheCreated'', all Frankensteins are made from pieces of at least two separate corpses. It's in the name - the first one was ''that'' Frankenstein's Monster. Theoretically, any Promethean can be a mix-and-match, but a Frankenstein ''has'' to be.
* ''TabletopGame/MagicTheGathering'':
** [[http://magiccards.info/fe/en/111.html Goblin Chirurgeon,]] whose art depicts one of his patients, who appears to include bits of at least four humanoid species.
** Phyrexians, who do this... and a bunch of other BodyHorror. [[http://magiccards.info/query?q=phyrexian+rebirth&v=card&s=cname Phyrexian Rebirth]] [[AssimilationPlot turns all creatures in play into this]].
** Innistrad uses this as the distinction between black zombies, which apply the rotting-reanimated-corpse model, and blue zombies, which are the product of blasphemous Frankenstein-style experimentation rather than blasphemous rituals.
* The ''TabletopGame/DiscworldRolePlayingGame'' features the "Patchwork Man" advantage, primarily so it can handle the ''Literature/{{Discworld}}'' novels' Igors.

[[folder:Video Games]]
* Agent 47 from ''VideoGame/{{Hitman}}'' (Chinese, German, Romanian, Russian and South American fathers).
* [[VideoGame/MetalGearSolid Liquid and Solid Snake]] being twins, are confirmed to be part-American, part-Japanese and part-Chinese (or whatever Eva is).
* Emerl from ''VideoGame/SonicBattle'' is designed to combine the movesets and personalities of the people he meets. When the only people he's met are Sonic and Tails, others can't tell if he's being rude or polite.
* A non-genetic example is Ermac from ''MortalKombat'', who is made up of the souls of hundreds of dead warriors bound into a humanoid body.

* ''Webcomic/{{Drowtales}}'': Rik the half dragon is something of a genetic experiment, and is ostracized by a society as a result.
* Grace from ''Webcomic/ElGoonishShive'' is human and also part squirrel, with alien DNA from an Uryuom and a Lespuko (sort of like an Uryuom, long story).
* Unity of ''Webcomic/SkinHorse'' is sewn together Frankenstein-style from mismatched parts.
* As is Quilt from ''Webcomic/DominicDeegan''.
* Baron Wulfenbach from Webcomic/GirlGenius is probably one of these. The family originally had three sons, but following a horrific lab accident two of them disappeared. It's commonly believed that the Baron is a construct made of the salvageable parts of all three. Even more explicitly, Agatha's foster parents Adam and Lilith, AKA Punch and Judy.
* ''Webcomic/{{Homestuck}}'': [[spoiler:The four main protagonists are all examples, all being made from the combined DNA of their guardians]].
* Molly in ''Webcomic/TheInexplicableAdventuresOfBob'' was grown using genetic material from many different animals--and some human DNA, taken from her "mother," Jean Poule.
* Nicole from ''Webcomic/QuantumVibe'' is an "osmotic clone" created from the genes of her mother and eleven anonymous donors. Her mom intended to use genes from ''2400'' people but couldn't get a viable fetus until [[spoiler: Seamus (one of the donors and Nicole's employer)]] suggested using whole chromosomes instead of pieces of them.
* ''[[Webcomic/TheAdventuresOfDrMcNinja Dr. McNinja]]'''s arc "Why a Gorilla?" has the Doctor face off against a three headed 4 armed ''Gorilla'' "Frankenstein".

[[folder:Web Original]]
* In ''Literature/{{Worm}}'', Blasto is apparently capable of creating these, and he attempts to make one out of [[spoiler: Myrddin and ''[[EldritchAbomination the Simurgh]]''.]] [[spoiler: Luckily, he fails; the result is nonviable due to the Simurgh's lack of conventional biology.]]
* Count Driscol, Captain Cedric and Bernard the Guard in Literature/DragomirsDiary were all originally separate people. But when all three were killed (two of them torn in half!), they were secured by a MadDoctor and cobbled together into a single, hideous creature. (Which, to be fair, can still split into three individuals, and even when they're together the three heads retain their distinct personalities.)
* Gordon of ''Literature/{{Twig}}'' describes himself as a "chimera," a stitched-together child made from approximately twenty-six different people in order to give him the best body possible. He experiences severe phantom pain episodes when his body tries to reject its own limbs.

[[folder:Western Animation]]
* Romy from ''WesternAnimation/PinkyAndTheBrain'' was supposed to be a normal clone of Brain, but DNA from Pinky was accidentally included in his creation, causing him to inherit traits from both mice.
* Serpentor from ''Franchise/GIJoe'' was created from the combined DNA of ten historical figures: UsefulNotes/JuliusCaesar, UsefulNotes/NapoleonBonaparte, UsefulNotes/AttilaTheHun, Philip II of Macedon and his son UsefulNotes/AlexanderTheGreat, UsefulNotes/IvanTheTerrible, UsefulNotes/VladTheImpaler, [[UsefulNotes/PunicWars Hannibal]], UsefulNotes/GenghisKhan, and UsefulNotes/GrigoriRasputin. Dr. Mindbender tried to get Creator/SunTzu as well, but was stopped by the Joes. Fortunately, that was apparently enough to throw his military competence out of whack.
* Delilah from ''WesternAnimation/{{Gargoyles}}'' is a combination of Goliath's current and former love interests, Elisa Maza and Demona - and the point where her creator Thailog's OedipusComplex officially becomes creepy.
** Long before that, there was Coldstone, a cyborg whose "organic" (so to speak) parts came from three different gargoyles; and the body has all three souls fighting for control. And just to complicate matters, they're in a LoveTriangle: a HappilyMarried couple and an evil male who wants the female for himself.
* The [[WesternAnimation/TeenageMutantNinjaTurtles2003 TMNT 2k3]] incarnation of the Rat King (a.k.a. "The Slayer") is one of these, using DNA from Bishop, Splinter, among other possible sources.
* This happens in ''WesternAnimation/TheSecretSaturdays'' when Zak and his pet komodo dragon and gorilla-cat are combined into one being.
* ''WesternAnimation/RobotChicken'' brings us the horror of Composite Santa: genetically/visually one-half Santa, one-half Frosty the Snowman. [[Anime/DragonBallZ Goku]] doesn't know what his powers are, "but he freaks me right the fuck out."
* One episode of ''WesternAnimation/AdventureTime'' has [[AnIcePerson the Ice King]] give up on kidnapping princesses...and instead just steal a bit from a bunch of them, stitching them together into a woman called Princess Monster Wife. Their relationship is oddly sweet, but she is so freakish that [[KidHero Finn]] and [[NonHumanSidekick Jake]] are unable to fight her, and she is so distraught over her appearance (and origin, when she discovers it) that she [[spoiler:pulls a HeroicSacrifice by returning her parts to their original owners]].
* [[spoiler: Superboy]] from ''WesternAnimation/YoungJustice'' is a clone created from the DNA of [[spoiler: Superman and Lex Luthor]]

[[folder:Real Life]]
* Chimera of this type can occur naturally when two embryo fuse in the womb. One case resulted in a woman whose apparent genome did not match her children's because her salivary glands and ovaries actually had two different genotypes.
** Recently it's been shown that everyone has a slightly different version of Chimeraism occurring from cellular interchanges during pregnancy. Babies pick up a few from mom and mom from the child. However, these are very few.
* In addition to sexual reproduction blending the DNA of two individuals, much of our DNA is in fact viral in origin. These viruses began somewhere else, often in another species.
** Probably most impressive is the DNA responsible for mitochondria, which are a necessary part of all multicellular organisms (and a fair bit of unicellular ones, too), and which is theorized to have its origins in some far prehistoric creature, now long-extinct on its own.
* Cloned animals are typically a Mix-and-Match of two parents: the animal from which they are cloned (which provides the nucleus of the lab-generated zygote), and the animal that provided an unfertilized egg (which provides the other cellular components). They have the chromosomes of their cloned parent, and the mitochondrial DNA -- what little of it there is -- of the egg-donor. Averted if the same female animal is used for both.