[[quoteright:347:[[WesternAnimation/MyLittlePonyFriendshipIsMagic http://static.tvtropes.org/pmwiki/pub/images/s_mad_eye_397.png]]]] [[caption-width-right:347: You might want to get that checked out.]]
If a character is deranged, or has just lost it for a moment, they are depicted as having one eye (or its iris/pupil) much larger than the other. Can also double as an unspoken OhCrap moment. For extra effect, may be paired with TwitchyEye.
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!!Examples:

[[foldercontrol]]

[[folder:Anime and Manga]]
* Just about everyone in the ''Manga/{{Hellsing}}'' manga.
* ''Solf J. Kimblee'' in a late chapter of ''Manga/FullmetalAlchemist''. He's telling Pride about how [[LovesTheSoundOfScreaming screams are soothing to him]]...
* A favorite shot of ''Anime/MagicalGirlLyricalNanoha'''s resident MadScientist, [[BigBad Jail Scaglietti]], when he's taunting the [[TheFederation Time-Space Administration Bureau]] via broadcast.
* ''VisualNovel/HigurashiNoNakuKoroNi'' has a lot of "emo-distortion" expressions, Mad Eye being just one of the effects. Rika busting this out in the second season is truly a sight to behold.
* [[http://www.mangafox.com/manga/mahou_sensei_negima/v29/c264/15.html Kurt Godel]] from ''Manga/MahouSenseiNegima'' (possible spoilers)
* Marik of ''Anime/YuGiOh'' did this from time to time, though he was crazy all the time, and this was because it was his dark side.
** In ''Manga/YuGiOhR'', Yako Tenma has this going on at least once in just about every one of his appearances after his StartOfDarkness. He's not quite right in the head, in case you couldn't tell.
* The entire cast of ''Manga/DeadmanWonderland'' exhibits this, sometimes as their default expression. It fits, since most of them are clinically insane to some degree.
* Ryuga does this quite often in ''Anime/MetalFightBeyblade''. It succeeds in making him appear quite off his rocker (and he is).
* 86 from ''Managa/{{Vassalord}}'' has this as his default expression. And when 86 gets serious somehow his eyes [[UpToEleven get even more crazy looking!]]
* Chuck from ''Anime/PantyAndStockingWithGarterbelt'' has one large white eye and a smaller black one.
[[/folder]]

[[folder:Comic Books]]
* ''ComicBook/JohnnyTheHomicidalManiac.'' Quite a lot of the time, really. But then, he's insane quite a lot of the time.
* Anything by JhonenVasquez has this.
* ''ComicBook/TheMask'': [[http://static.tvtropes.org/pmwiki/pub/images/the_mask_comic_cover.jpg]]
* Falling under the "Deranged Character" subset are SelfDemonstrating/TheJoker's eyes as drawn in ''Batman: RIP''. There, one of his pupils is drawn slightly larger than the other, giving him a dangerous and mentally off-kilter look. The effect is so slight that it's only noticeable in close-up shots of the character, but it's definitely there. Then again, he is a MonsterClown with enough crazy to fill Arkham Asylum's halls ten times over.
* Most Returners in ''ComicBook/DeadEyesOpen'' seem to have one eye permanently open with a shrunken pupil.
* A specialty of AlanDavis. In the classic [[{{Batman}} Detective Comics]] story "Fear for Sale", he combines this with an ExpressiveMask.
[[/folder]]

[[folder:Film]]
* In ''[[WesternAnimation/{{Nine}} 9]]'', [[WaifProphet 6]] has one eye slightly larger than the other as a permanent feature, confirming his {{Cloudcuckoolander}} status.
* In ''The New Guy'', [[MagicalNegro Luther]] teaches [[NaiveNewcomer Dizzy]] his "Crazy Eye" which consists of squinting one eye and opening the other wide.
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[[folder:Literature]]
* The aptly-named Mad-Eye Moody from ''Literature/HarryPotter'' has a magical replacement eye. It's bright blue, the size of a golf-ball, has 360 rotation and can see through just about anything. It's also virtually never looking in the same direction as his other eye.
* The unnamed old man in Creator/EdgarAllanPoe's classic ''The Tell-Tale Heart.'' One eye, due to some deformity, is described as a "vulture eye" with a film over it. However, the eye drives the old man's ''roommate'' to insanity (whether this roommate is his servant, his apprentice, a caretaker or even his spouse is never mentioned).
* The Scarecrow from ''Literature/TheWonderfulWizardOfOz'' is described as having one eye larger than the other (accompanied by mismatched ears) due to poor artistry on his creator's part. He [[TheStoic never really loses his cool]] at any point in the book, and he is never depicted as any more crazy than [[{{Cloudcuckooland}} the rest of the Ozians]], so it might be considered Subverted.
* The RedRightHand of the mercurial SerialKiller [[NamesToRunAwayFromReallyFast Karkas]] in ''Literature/GalaxyOfFear'' is that he has one "crushed" eye.
* ''Literature/ScorpionShards'': Everyone maddened by Dillon gets one dilated pupil and one pinpoint pupil
[[/folder]]

[[folder:Mythology]]
* Having a literal Mad Eye is OlderThanPrint: Cuchulain, the [[CelticMythology Irish]] folk hero. Whenever he went into one of his unstoppable rages, one of his eyes would get smaller and the other would get bigger. " ... he sucked one eye so deep into his head that a wild crane couldn't probe it onto his cheek out of the depths of his skull; the other eye fell out along his cheek." Now ''thats'' a Mad Eye.
[[/folder]]

[[folder: New Media ]]
* This guy: [[{{Emoticon}} o_O]]
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[[folder: Newspaper Comics ]]
* Bill the Cat from ''ComicStrip/BloomCounty''.
* Cartoonist Steve Bell depicted Tony Blair with an increasingly [[http://www.guardian.co.uk/cartoons/stevebell/0,,922269,00.html mad eye]].
* Sometimes used in ''ComicStrip/{{Garfield}}'', often when characters have had [[http://blog.flickerbox.com/wp-content/uploads/garfield.gif really strong]] [[http://img4.photobucket.com/albums/1103/susanweise/garfield_coffee.gif coffee]].
[[/folder]]

[[folder: Tabletop Games ]]
* One ''TabletopGame/{{Paranoia}}'' mission has a GeneralRipper who "glares at his subject with one bulging and one squinting eye: paranoid fear and clinical suspicion".
[[/folder]]

[[folder: Theme Parks ]]
* The Ghost Galaxy in ''Space Mountain: Ghost Galaxy'' has one skeletal-eye-socket and one giant blue nebula-eye.
[[/folder]]

[[folder: Video Games ]]
* King K. Rool from the ''VideoGame/DonkeyKongCountry'' game series.
* ''VideoGame/EarthwormJim'': Jim himself.
* In the re-render of ''VideoGame/KingdomHeartsChainOfMemories'', Vexen gains one of these.
* Laverne from ''VideoGame/DayOfTheTentacle'' has one eye bigger than the other permanently. [[AmbidextrousSprite Which one depends on what side of her head you're looking at.]]
* Similarly, Doug Rattmann from the ''VideoGame/{{Portal}}'' games has one pupil permanently larger than the other. He's also a paranoid schizophrenic.
* Whenever Glottis from ''VideoGame/GrimFandango'' gets excited about cars, or customizing something else with a motor or wheels, or gambling, he goes crazy-eyed, rapidly switching from one side to the other.
* In the Creepy and Cute pack for ''VideoGame/{{Spore}}'', one of the added emotes [[CaptainObvious (for the creepy side of things)]] is a version of this. HilarityEnsues when ''[[SugarWiki/FunnyMoments your creature is covered entirely in]] [[EyesDoNotBelongThere eyes.]]''
* In ''[[VideoGame/KunioKun Nintendo World Cup]]'', characters would get this when stunned by a tackle.
* Crazy Dave from ''VideoGame/PlantsVsZombies''. He's craaaaaazy. All the zombies in the game also have larger left eyes.
* For some reason, Liara in the ''Franchise/MassEffect'' series is often shown with one eye squinting slightly more than the other, prompting many a joke along this line.
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[[folder:Webcomics]]
* Black Mage, from ''WebComic/EightBitTheater'' does this a lot, and was stuck for a while after a particular bit of frustration. As he put it after listening to one of Red Mage's "plans", "That's so stupid I can't even see straight."
* The titular amorph from ''Webcomic/SchlockMercenary'' has one eye that is literally larger than the other, and the cartoonist is consistent about which is which, and what side each is on. Since Schlock can move his eyes around it doesn't really matter though.
* Several characters in ''Webcomic/GirlGenius'' do this sometimes... and there's one, a [[FrankensteinsMonster construct]], who really ''does'' have one eye bigger than the other.
* Bob from ''Webcomic/BobTheAngryFlower''. When Bob's scorching feral mania comes to the fore, he gets the Mad Eye.
* Vatsy, the insane journalist from ''Literature/VatsyAndBruno'', is always drawn with one eye in shadow to accentuate his wrong-ness.
* [[http://www.webcomicsnation.com/shaenongarrity/narbonic_plus/series.php?view=archive&chapter=37339#strip6 Helen Narbon]] of ''Webcomic/{{Narbonic}}'' gets this occasionally.
* Kano of ''Webcomic/{{Kagerou}}'' is frequently seen with pupils of very different sizes, though his actual ''eyes'' are the same size. The effect is halfway between Mad Eye and heterochromia.
* Nova from ''Webcomic/KeychainOfCreation'', especially when in MadScientist [[http://keychain.patternspider.net/archive/koc0136.html mode]].
* Used in ''Webcomic/CommanderKitty'' to show [[http://www.commanderkitty.com/2009/08/23/obedience/ intense pain]], or to illustrate the [[http://www.commanderkitty.com/2012/08/05/whos-the-crazy-one-here/ sudden, terrifying feeling]] of being the OnlySaneMan amongst a crazy crew that insists you get a costume change.
* In [[http://www.egscomics.com/sketchbook/?date=2003-03-30 this]] ''Webcomic/ElGoonishShive'' sketchbook strip, [[AuthorAvatar Dan]] gets this while explaining his "master plan".
* ''WebComic/{{Drowtales}}'': One cameo character, [[http://www.drowtales.com/wordpress/wp-content/uploads/2012/06/20120627Cacbolg-news.jpg Cac'bolg]], has eyes like these. This emphasizes the fact that he's a member of Vel'Vloz'ress, [[ArmyOfThievesAndWhores the most messed up and chaotic faction]] in all of Chel'el'Sussoloth. Also, he seems to have some kind of obsession with poisons.
[[/folder]]

[[folder: Web Original ]]
* Bubs, from ''WebAnimation/HomestarRunner'', definitely looks like this, but is no more crazy than the rest of the cast.
* The eponymous character from ''SpoilsburyToastBoy'' [[http://static.tvtropes.org/pmwiki/pub/images/toastboy.png has this permanently]], as does his sister.
* ''WebAnimation/ZeroPunctuation'' will sometimes show these, usually of the OhCrap variety, having a character with one eye as a ring and the other as a circle.
[[/folder]]

[[folder: Western Animation ]]
* Bumi from ''WesternAnimation/AvatarTheLastAirbender''.
* Many characters from ''WesternAnimation/InvaderZim'', including the titular invader on occasion.
* Mr. Demartino from ''WesternAnimation/{{Daria}}''.
* Blitzwing from ''WesternAnimation/TransformersAnimated'' has asymmetric eyes in ''one'' of his three faces. He's definitely crazy, having [[SplitPersonality three personalities]] and all, but the odd-sized are on the most calm and calculating face. Really, it's mostly there to make it look like a [[HighClassGlass monocle]], as an {{homage}} to [[Series/HogansHeroes Colonel Klink]].
* Shado the Brain Thief from ''WesternAnimation/HarveyBirdmanAttorneyAtLaw''. His mad eye alternates from right to left.
* Uncle Ruckus in ''WesternAnimation/TheBoondocks''.
* ''WesternAnimation/TheTick'' -- the title character, who is never entirely straight.
* Vince from ''WesternAnimation/RexTheRunt'', one of the more random oddballs in claymation: given to random fits of Pavarotti and tangential one-word sentences.
* The starring spider in the (still unfinished) Art Institute of Portland student production ''Tangled Web'', sometimes. Then again, he's decided to become a vegetarian and is desperate to avoid the delicious, delicious fly that's just landed in his web, so can you really blame him?
* In ''WesternAnimation/AnAmericanTail: Fievel Goes West'', Wiley Burp teaches Tiger how to intimidate someone using "The Laaaayyyyzzzzyyy Eyyyyye!" which is essentially an intentional ecovation of this trope.
* The Vigar puppet on ''WesternAnimation/BRATSOfTheLostNebula'' was the first one with different sized eyes to be approved by Brian Henson.
* VERY evident on ''WesternAnimation/EdEddNEddy.'' "Boy Double D. Eddy never stares at ME like that."
* In ''WesternAnimation/TheCritic'', Duke Phillips once answered a reporter's question by telling him to "stare deep into the hypnotic powers of my [=EEEeeevil=] eeeye!" [[HypnoticEyes It apparently works.]]
* Discord of ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' has red eyes with two irises of different sizes to illustrate his...discord!
** More commonly used on the show as a brief, unspoken OhCrap moment on the part of the rest of the cast (pictured above).
* Two-Face gets this treatment as an effect of stylization in ''WesternAnimation/BatmanTheAnimatedSeries'', as does Jonah Hex in the episode "Showdown." Characters that aren't completely human, such as Man-Bat and Clayface, sometimes do this.
* Dr. Mystico on ''WesternAnimation/{{Freakazoid}}'', as if his introductory speech weren't enough of a giveaway.
[[/folder]]

[[folder: Real Life]]
* Anisocoria, or asymmetric pupil dilation, can be a sign of serious neurological problems. This is also one of the first things [=EMTs=] check for when they suspect a concussion.
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