Some authors hold that their character's powers shouldn't run exclusively on the RuleOfCool, and decide to inject some (relative) [[RealityEnsues realism]] into the situation, resulting in a hero whose weakness is a bit different from the rest of the Super crowd.

These guys aren't allergic to [[WeaksauceWeakness arbitrarily chosen household items]], nor [[KryptoniteFactor strange items related to their origin story]]. ''Their'' weaknesses are, in fact, a direct result of their particular superpowers. For example, a character who can [[PlayingWithFire summon fireballs]] may find themselves powerless during a rainstorm, or a ShockAndAwe hero might find themselves at risk of electrocuting ''themselves'' in the rain. With characters whose powers rely on uttering {{Magical Incantation}}‎s or [[MakeMeWannaShout projecting a really loud voice]], a good strong gag may be enough to disable them. Someone with SuperSenses may find them to be a double-edged sword if subjected to SensoryOverload. Sometimes this can stem from a lack of RequiredSecondaryPowers, like a hero with SuperSpeed but not SuperReflexes finding themselves going TooFastToStop.

The superpower may be something completely fantastic, but a writer may add a new twist to it by following the fantasy as if it was true and exploring the logical ramifications of it. For example, a LivingLieDetector that notices when people lie because of their heart beats. Perhaps no writer before you had ever thought that a guy with a pacemaker would fool this trick. Go ahead and use it, it will become a standard for future writers.

Whatever the case, this type of superpower-induced weakness can function as a DramaPreservingHandicap, or it can be PlayedForLaughs. It may also create ElementalRockPaperScissors between different heroes. Sister trope to ImmunityDisability: being immune to something sometimes will naturally have its own drawbacks.

Not related to the PuffOfLogic. May be an aversion of RequiredSecondaryPowers. Contrast OutsideTheBoxTactic, when the solution to defeat an enemy is logical but not immediately obvious.

----

!!Examples

[[foldercontrol]]

[[folder: Anime and Manga ]]
* In ''Manga/FullmetalAlchemist'', the fact that [[PersonOfMassDestruction Roy Mustang]] is useless [[WeaksauceWeakness when it's raining]] is something of a RunningGag. This is because, well, ''he [[PlayingWithFire uses fire]]'', and rain is going to put a bit of a damper on his ability to get a flame going. However, this is only when ''he himself'' (specifically his hands) are wet, because if something else is covered in water he can just decompose it into hydrogen and oxygen then ignite that. This is because his gloves are made from a special material that cause a spark when he snaps, when combined with transmutation circles on the back let him do his alchemy. Give him another source of flame and he can overcome them being wet.
** Pride's LivingShadow powers don't work in total darkness since he needs a light source to cast a shadow. It's also weak to the flashbang that Alphonse used since the light is too bright to cast a shadow (not to mention he uses the shadow to see).
** Wrath has the Ultimate Eye that allows him to instantly predict what will happen in battle, allowing him to perfectly dodge, block, and strike no matter what the opponent does. The one weakness is that it's an eye, and its power is therefore sight-based: it cannot predict an attack if it cannot ''see'' the attacker.
* In ''Manga/EtCetera'', the Eto Gun and the Zodiac use various essences to fire bullets, which based of the Chinese Zodiac and the constellations, respectively. For example, you would need something from a cow to fire an Ox bullet, a fish to fire a Pisces bullet, etc. If there's no essence available, the guns are little better than the toys they resemble, being unable to fire.
** Speaking of the Pisces bullet, it's created with essence from a fish, so it only works in the water. [[spoiler:Unless the essence came from a flying fish]]
* Manga/{{Naruto}}'s Rasen-Shuriken attack is essentially a flechette bomb that attacks organisms' individual cells. It has a tendency to do this to the person who is holding it as well as the target.
** Kinkaku and Ginkaku subvert this with one of their ninja tools, which causes people to be sucked in if they say the word they say most in life. Ordinarily, not saying anything would be an easy way to avoid falling victim to the tool's effect, but anyone who remains silent for too long also gets pulled in.
*** Their tools have a logical weakness as well: They constantly drain large amounts of chakra from anyone holding them. Only somebody with chakra comparable to a jinchuuriki can safely handle them for any length of time. Tenten tried using one of them and ended up near death after the battle.
** Shikamaru's shadow powers, which often require his shadow to touch the enemy's, are often influenced by the amount of light available. For example, one FillerVillain manages to escape his jutsu with a smoke bomb.
** Water jutsus often require existing sources of water to be effective. As such, one FillerVillain (who uses his Twin Tonfas as dowel sticks) is defeated by being lured to an area with virtually no groundwater.
** Tobi's abilities to make himself intangible. Of course, he can't attack while phased, since it would just go through his foe. The best time to attack, then, is when he attacks. He does try to get around this when fighting Minato by using chains that trail behind him, in order to catch foes who he phases through.
** Also, due to [[spoiler: shared Mangekyo Sharingans]], Tobi's phasing is absolutely useless against [[spoiler: Kakashi; he can ''match phases'' with Tobi and attack him either way]].
** As with Taskmaster (see comics section), Sharingan users do not gain any RequiredSecondaryPowers to any techniques they copy; they are still subject to the particular shinobi's personal limitations. Sasuke's attempts to copy Lee's taijutsu being the most cited example (Lee is a taijutsu ''specialist'' due to a lack of aptitude in the other arts, so his body is at a level of conditioning the more-balanced Sasuke can't match).
* The Devil Fruits of ''Manga/OnePiece'' can frequently fall into this.
** Luffy's rubber body, which makes him more or less immune to blunt force, renders him no less vulnerable to blades than he ever was. For Luffy, heat also apparently makes him extra squishy.
** God Eneru's lightning-based powers had no effect on rubber, thus allowing Luffy to harm him. But even then, Eneru had Observation Haki that allowed him to predict any attack, so Luffy still couldn't hit him. Luffy got around that by ricocheting his punches off of a wall. Since Luffy wasn't consciously controlling where his attacks were going after they ricocheted, Eneru couldn't predict them, and he got pummeled. Eneru eventually lost to an attack that he could foresee but not until it was too late because it was too fast.
** One of Eneru's top fighters, Satori, has the same ability to predict any attack and relies on it so much that he finds himself helpless when he gets attacked by something he cannot escape from.
** Perona has the power to generate ghosts that strip anyone's spirit and optimism from them. But to her shock, they don't work on Usopp. He's such a ''pessimist'' he actually inverts the power: depressing the ghosts ''and even Perona herself''.
** Magma beats fire, which would probably beat ice. And for an odd example, the more or less completely useless [[OvershadowedByAwesome by this point]] Mr. 3's wax power in fact blocks almost every single poison Magellan has, although it is almost completely useless in the intensely hot fourth level of the prison.
** Several Alabastan soldiers [[SenselessSacrifice drink a potion that]] [[DangerousForbiddenTechnique makes them extremely powerful, but kills them in minutes]]. Crocodile realizes this and decides to simply wait out the duration, out of reach of their attacks, letting them die. Crocodile's was finally defeated when Luffy figured out that Crocodile's ability to turn into sand can be hampered by becoming wet, so Luffy coated his hands with his own blood, allowing his punches to work.
** Logia in general fall into this category, as they are literally elemental beings (though not always stuff we'd consider "elements"), and as such are vulnerable to the weaknesses of that element. Lightning losing to rubber, sand losing to liquids making it stick together, candy (no, seriously) losing to cooking flour that negates its stickiness so that attacking enemies won't become trapped, etc. Considering how powerful a Logia is, and how invulnerable they are, exploiting a logical elemental weakness is one of the few things on the entire planet that can even potentially harm them, unless a person has Armament Haki, which lets them hurt Logia users even if they're in an elemental form. Plus there's the matter that Logia are more sensitive to water than other Devil Fruit users: as in Luffy can get splashed and still fight (even if he's submerged, he just can't move himself though others can still manipulate his body), while if someone like Smoker gets doused, he can't transform the wet body part until it's dry.
** Franky [[WeCanRebuildHim became a cyborg after suffering severe injury]], giving him numerous gadgets and a super-durable steel body. However, since this was achieved by operating on ''[[SelfSurgery himself]]'', his back is unprotected--he can't modify something if he can't see or reach it.
** A villain in a {{Filler}} arc had the Pet-Pet Fruit, which created {{Hypno Trinket}}s that made anyone affected by them [[PeoplePuppets have to obey his orders]]. Trafalgar Law defeated this by putting in ear plugs, since someone who can't hear the orders, logically, couldn't obey them.
* In ''AngelicLayer'', Hikaru is created to be super fast and agile. The problem is that because she is so light, she doesn't have very much strength. She's also unable to fight well on places like an ice field.
* Similar to the One Piece Eneru example, in ''CodeGeass R2'', Suzaku was able to exploit his instinctive fighting style and his Geassed command to "live" to be able to maneuver the Lancelot Albion so fast that Bismarck's Geass, that lets him see a few seconds into the future, still cannot provide enough of a head start to counter it.
* ''Anime/DarkerThanBlack'' loves this. The guy with [[ShockAndAwe electricity powers]] needs something that conducts electricity if he wants to attack at a distance, the guy who can [[AnIcePerson freeze stuff]] needs water (or your arm) within reach to be able to do anything, and in the first episode of the second season, someone with SuperSpeed who tries to run in a rainstorm winds up riddled with holes due to [[InertiaIsAHarshMistress elementary]] [[TooFastToStop physics]].
* ''Manga/MedakaBox'' loves this trope. The best example is probably the array of weaknesses that Yukuhashi Mizou's abnormality, mind-scanning, has, thanks to it working really, really good. [[spoiler: Catching even the smallest thoughts, he can't decipher input from a person who does not think clearly and jumps from one thought to another fast enough for it to be of use; he cannot function in the crowds by himself, due to being overwhelmed by the stream of thoughts; he feels pain that the people within his reception range feel; and, finally, he cannot fight a good person who honestly had legitimate reasons to oppose him, without seeing how they think and starting to empathize with them.]]
* Many of the Clow Cards from ''Manga/CardcaptorSakura'' have logical weaknesses. One example: Sakura managed to capture the Watery card by trapping it in an industrial-sized freezer.
* In ''Manga/MahouSenseiNegima'' [[spoiler:Negi gets superspeed]] by turning into lightning. This is countered by Rakan pointing out that lightning gives off positive streamers at the destination meaning he knows where it's going to strike. And because his perception isn't sped up as well he can't properly control himself.
* Keima, the main character of ''Manga/TheWorldGodOnlyKnows'', is a legendarily skilled player of Dating Sims in which one pursues girls. However, the opposite of this (girls pursuing ''him'') frequently leaves him at a loss.
* In ''Manga/FutureDiary'', police detective Keigo Kurusu's future diary feeds him data from whatever investigation he's currently conducting. The solution? [[spoiler:Expose his DirtyCop ways and get him kicked off the force, meaning he's not on any investigation, totally bricking his diary.]]
* Accelerator from ''LightNovel/ACertainMagicalIndex'' is practically invincible due to his power--changing any vector he wants. He can easily deflect bullets, kill someone by [[CruelAndUnusualDeath reversing their bloodflow]], turn air into plasma bombs, et cetera. However, much like Firestorm in the Comics section below, he has to actually mentally perform all the relevant calculations to do any of this. [[spoiler:Brain damage]] all but cripples his abilities.
** Accelerator has also learned not to stand in the middle of gigantic explosions, as the fire tends to consume all the oxygen around him. Complete invincibility to external attacks doesn't mean much if you can't breathe. Although, he says he could get around this by simply carrying around a small air canister.
** [[spoiler:As of New Testament, he cannot deflect HollywoodVoodoo because there are no vectors to redirect.]]
** Subverted with Touma's Imagine Breaker, which [[AntiMagic annihilates anything supernatural]] it comes into contact with... quite a GameBreaker when up against sorcerers and espers. However, the power is confined to only his right hand. Therefore, if one were to sever his right hand, the ability would be nullified, no? [[spoiler:Turns out the AntiMagic is merely a side-effect of Imagine Breaker's power: its real purpose is to be the lock on some sort of EldritchAbomination within Touma that is released if his hand is ever cut off. Said being is also about the third-strongest entity in known existence as well. Chances are, if you were having trouble with a magic-cancelling right hand, you're not powerful enough to deal with ''that''.]]
* In ''Manga/{{Bleach}}'', Aizen's zanpakuto can completely control the perceptions of anyone who sees him release it even once. It thus stands to reason that [[spoiler:Tousen, a blind captain, who cannot see it, must be recruited to his side, and Ichigo is at an advantage over him, never having seen him release his zanpakuto. Also, [[FridgeBrilliance Yamamoto's flame shikai and bankai can not be tricked by illusions]], so that's why Aizen won't confront him head on.]]
** In fact, Yamamoto's plan to counter Aizen was quite literally [[spoiler: KillItWithFire by basically NUKING the entire area - it doesn't matter if he can't see Aizen, he knows Aizen is SOMEWHERE close, and hence within the blast zone. Without Wonderweiss it might very well have worked.]]
* In ''Manga/YuYuHakusho'', similar to the Manga/{{Naruto}} example above, Kaito's ability to steal the soul of anyone who says the forbidden word is useless if no one speaks at all. Kurama, who has figured this out, proposes an alternative in which the condition gets stricter over time, and convinces Kaito to accept by adding the condition that if neither of them has violated the condition when the time has expired, Kurama will lose his soul, putting Kaito at an advantage. Much earlier, a demon tried to cast an incantation to shrink Yusuke. However, the spell backfires and shrinks ''him'' instead. Genkai explains that these kinds of incantations rely on a receptive ear, and as it turns out Yusuke's ears were inadvertently ''plugged'' at the time, leaving only one target for the spell.
* In ''Manga/{{Holyland}}'', Tsuchiya having to go low to tackle exposes his back of neck and puts his head in easy reach of kicks.
* In ''Manga/FairyTail'', Wendy Marvel, the [[BlowYouAway Sky Dragon Slayer]], can eat air (this is not the same as breathing) to increase her strength and heal herself. While she is potentially invincible, since unlike other Dragon Slayers, her element is EVERYWHERE, she would get sick if she tried this when the air is polluted.
** One of the antagonists, [[MeaningfulName Cobra]], both subverts and plays it straight with one of his strongest abilities: {{Telepathy}}. Since he can hear another's thoughts, you'd be forgiven if you thought it could be stopped by thinking different from what you're really gonna do or flooding your mind with multiple thoughts to confuse him. Nope, [[DangerouslyGenreSavvy turns out he's aware of both those problems]]. However, it ''is'' rendered useless if his opponent isn't aware of those thoughts themselves. In other words, if his opponent attacks without thinking entirely, or rather, fights instinctively, he can't predict their actions. It also doesn't work on those [[LaserGuidedAmnesia who have no memory]].
*** Hiro Mashima has used this trope before in ''RaveMaster''. During one battle, Haru was facing a mind-reading opponent, so he comes up with an unusual use for Rune-Save: a magic sword whose power is based on ''sealing''. He invokes its power to seal ''his own mind'' momentarily: just long enough to land a combo that defeats his opponent.
* In ''Franchise/{{Anpanman}}'', the bread-headed superheroes have water and mold as their weakness, seeing as they both make bread soggy and inedible. Baikinman and his Kabirunrun, being an alien bacterium and mold spores respectively, have soap and cleanliness as their weaknesses, with Mushibakinman, a cavity germ of the same species as Baikinman having a weakness to toothpaste. Also, the donburi-headed characters, being bowls of rice with a topping, lose all their powers if their bowls are emptied. Finally, Kurayamiman and the Ice Queen, being darkness and ice incarnate, both are weak against the sunlight.
* Shows up at several times in ''Manga/DailyLifeWithMonsterGirl''. The literally cold-blooded [[SnakePeople Miia]] is susceptible to cold temperatures, [[HarpingOnAboutHarpies Papi]] can't fly when she's wet, [[BlobMonster Suu]] can get diluted when exposed to too much water, [[OurMermaidsAreDifferent Meroune]] gets poisoned by swimming in chlorinated water the same way a human would by breathing bleach fumes, and [[SpiderPeople Rachnera]] can't handle extreme heat or cold.
* The manga of ''Manga/KingdomHeartsChainOfMemories'' has Larxene defeated in such a way. [[spoiler:Sora and Donald combined their Fire and Ice spells to soak Larxene. This resulted in her electrocuting herself when she tried to use her lightning spells on them.]]
* This comes up sometimes in ''Manga/JojosBizarreAdventure''. Most notably, Vanilla Ice in Part 3 has a brutally powerful Stand, Cream, whose power is to disintegrate anything it touches. He climbs inside of it when it's used. Polnareff, however, realizes that when Ice is inside Cream, ''he can't see'' - to protect himself from Cream's power, he has to close its mouth, leaving him literally attacking blind. [[spoiler:He's also worked out that Vanilla Ice is a vampire, something Ice himself hasn't realized, and so he tricks him into blowing several holes in the wall. The sun's still up.]]
* In ''Anime/AldnoahZero'', Trillram pilots a mecha with a energy shield that disintegrates anything that touches it. However, this comes with the disadvantage of [[spoiler:blocking out all light, forcing the pilot to rely on remote sensors for guidance. Also, by necessity, there are gaps in the field to allow the mech to walk without falling through the ground, and to be able to receive the feed from his sensor drones. The protagonists exploit these vulnerabilities to great effect.]]
** This is how the Earth forces, armed with [[RealRobotGenre fairly standard mechs with conventional weaponry]] manage to keep up with the Martians' more esoteric attacks. For instance, a RocketPunch is deflected with a pinpoint-accurate shot to deflect its momentum, and a mech armed with plasma swords [[spoiler:is dumped in the ocean - the heat causes a tremendous steam explosion that vaporizes the mech instantly.]]
* Many Quirks in ''Manga/MyHeroAcademia'' have weaknesses in the form of low-level {{Heroic RROD}}s, running the risk of injury if over- or improperly used. These risks are often a direct result of the particular power. GravityMaster Uraraka experiences symptoms of vertigo. Kaminari short circuits his own brain and temporarily becomes a dullard if he unleashes his full ShockAndAwe. Mineta, who can pull sticky balls from his body, will begin bleeding if he does too many at once.
* Many of the heroes on ''LightNovel/HighSchoolDxD'' have logical drawbacks to their powers:
** Issei's [[AmplifierArtifact Boosted Gear]] will [[MagikarpPower double his power every ten seconds]] - that means it [[HeroicWillpower usually]] takes ''at least'' a minute of combat before he's up to snuff. Additionally, he's otherwise an average human - or in other words, a mediocre Devil - and needs to train extensively to put that power to use.
** Kiba also relies on technique to make the most of an incredibly flexible Sacred Gear, making attacks to his legs a glaring weakness.
** Koneko is [[MightyGlacier incredibly strong and nearly indestructible]], but not particularly nimble. Anything that can fly can avoid her easily, especially if there's nothing around to throw - this is a problem when most of her enemies have wings.
* ''Manga/ShokugekiNoSoma'': Soma is a very experienced and skilled chef, and has worked on-and-off at his dad's "special-of-the-day"-restaurant since he was ''three''. However, he is clearly out of his depth when faced with any situation when his experiences aren't applicable. He flounders with kitchen French, fails to consider his dish's staying power on a heat plate when devising a recipe for a buffet (a situation which would never occur at his dad's restaurant), can't keep up with cooking multiple multi-course meals (as opposed to single dishes, one at a time), and struggles with making the type of high-impact foods that win cooking contests, as opposed to the "enjoy-the-meal" style he's used to.
[[/folder]]

[[folder: Comic Books ]]
* In ''ComicBook/{{Runaways}}'' Victor is a cyborg and can't pass through metal detectors without setting them off.
* ComicBook/PlasticMan, because of his rubber based powers, has been known for having a vulnerability with extreme temperature changes and (in some incarnations) being in contact with acetone.
* {{Wolverine}} of ComicBook/{{X-Men}} can't pass through metal detectors because of his skeleton. He is also vulnerable to magnets. (This doesn't stop him from attacking {{Magneto}} as if he doesn't remember what happened the [[CurbStompBattle last zillion times]].)
** Of course, this doesn't stop him in any story that requires him to travel by plane. At least once this has been played for laughs, with Wolverine and another character walking out of an airport while she comments on how she's always wondered how he got through metal detectors and now she knows. The reader, of course, is not privy to this information.
** Once, he walked into the Pentagon, and showed a medical certificate stating he has metallic prosthetics due to war injuries. Not far from the truth.
** In the Ultimate Universe, he once got in by sticking a (fake) grenade into some guy's bag so airport security would freak out and he could sneak past the detectors in all the confusion... Ultimate Wolverine is a bit more of a {{Jerkass}} than regular Wolverine.
* Humorous example verging on a WeaksauceWeakness: the Sandman was first defeated when SpiderMan ''vacuumed him up.''
** He also once teamed up with Hydro-Man, until they realized that if they touched, they combined into a sort of sludge. They got stuck that way for a while.
** Similarly, intense heat or electric attacks can turn him to glass. Sometimes when fighting the Sinister Six, Spidey and other heroes use DeadlyDodging to get Electro to do this.
* Shadowcat of the ComicBook/{{X-Men}} can only stay phased inside an object as long as she can hold her breath. When the character debuted, it was pretty clear that she couldn't breathe ''at all'' while phased, which made sense because air, while not solid, would still be out-of-phase relative to Kitty.
** This was either a source of FridgeBrilliance because there's no air inside solid objects, and the air wouldn't move with her. It would just dissipate.
** This limitation was invoked for story reasons, to make the character sometimes vulnerable when in costume. It changed to its current interpretation around the time of the Mutant Massacre, when she got injured and her default state became "phased". If she couldn't breathe while phased, this would have killed her quickly.
** Also [[RequiredSecondaryPowers averted]] in that she is never shown [[RequiredSecondaryPowers dropping through the center of the Earth]] whenever she phases, so it is assumed she can apparently create phase boundries on the soles of her feet allowing her to walk on solid ground even though she is out of phase with it. She examined the FridgeLogic of this and learned that 'down' was what she made of it. She can walk on ''nothing,'' a power that she's used to great effect on several occasions.
*** Used as a weakness in one instance, when a BrainwashedAndCrazy Wolverine attacks her by stabbing her not-phased foot. Ouch.
* Colossus of the Comicbook/{{X-Men}} can turn himself into organic steel completely, including all the internal workings of his body. Apparently he does not have blood in this form (and neither does it require it). One downside to this is that if something does manage to injure him through the NighInvulnerable status, turning back into the more frail and bleeding human form would be a Very Bad Idea. Fortunately he can still heal with time. In his metal form, the equivalent of setting broken bones requires heavy machinery.
* ComicBook/{{Firestorm}}'s main power is transmuting matter. He can change practically anything into practically anything else, such as [[{{Alchemy}} lead into gold]], or air into gold, or bullets into water, or water into plutonium. Not even considering his additional powers, this would make him nigh-godlike, except for a LogicalWeakness: he has a normal human mind and no SuperSenses, so he needs to mentally keep track of the chemical composition of everything he transmutes. This means that he can transmute things freely into elements and very simple compounds (like water (H[[subscript:2]]O) or salt ([=NaCl=]), and maybe even TNT (C[[subscript:6]]H[[subscript:2]](NO[[subscript:2]])[[superscript:3]]CH[[subscript:3]]) at most), but making things more complicated than that requires great concentration, if he can do it at all.
* Having witnessed the fiery deaths of his family, along with the rest of his species, the ComicBook/MartianManhunter now suffers from pyrophobia. (The pyrophobia of the ''other'' Martians is handwaved as being a psychic block implanted by the Guardians of the Universe to stop them becoming too evil or something, but with J'onn [[FridgeBrilliance it makes sense]].)
* While not his most prominent weakness, Franchise/{{Superman}} is at least hurt by high powered sonics. His SuperSenses and invulnerability seem to roughly cancel each other out in this instance.
** His weakness to red sunlight fits as his powers depend specifically on yellow sunlight. The ComicBook/{{New 52}} and most recent movie incarnation depend on multiple factors of Earth's atmosphere for their powers, thus exposure to a Krypton like atmosphere can shut his powers down.
** His super resistance to injury proved a problem when he was shot with a kryptonite bullet and needed surgery. Fortunately, the surgeon was clever enough to use a shard of the bullet he could access to weaken Superman just enough to make the incisions necessary to extract the rest.
* Quite a few heroes with regeneration powers have logical weaknesses as a result. [[TheSavageDragon Savage Dragon's]] bones will knit wrong if not set quickly (forcing him to re-break them), Claire from ''Series/{{Heroes}}'' avoids this by having her healing not kick in until foreign objects are removed and bones set but this obviously has its own drawbacks as Claire can be stuck unconscious until someone happens along to help her. Batman once faced a dilemma trying to remove a kryptonite bullet from Superman as the wound was closing around the bullet too quickly and he was still tough enough to resist surgical instruments. SelfDemonstrating/{{Deadpool}}'s regeneration does not mix well with his cancer.
** Deadpool's regeneration is actually tailored to work ''with'' his cancer. It replaces cells killed off by the cancer at around the same rate that the cells are killed off, with room to spare for other wounds and injuries. A group of Skrulls, during the Secret Invasion storyline, tried to make a group of Skrulls with his healing factor... but without the cancer to hold the healing in check, they overhealed and exploded.
** FridgeLogic hits hard though when you remember that cancer ''itself'' is uncontrolled cell growth.
*** Which his healing factor cuts down to normal-ish levels. His entire body is pretty much one big human-shaped mass of cancer cells, constantly dying and regenerating again. Is it any wonder why he's completely, utterly insane?
* SpiderMan has been shown to be susceptible to pesticides that affect spiders. He can't stick to surfaces that are sufficiently slick. His spider sense can also be rendered useless or even a drawback if faced with overwhelming danger from multiple sources.
** IronMan also proved that if Peter can build a tracer that emits a signal detectable by his spider sense then others can build devices to trigger false positives in his spider sense rendering one of his greatest advantages useless.
* Most Marvel magical heroes, like [[YoungAvengers Wiccan]], the ScarletWitch, and ComicBook/DoctorStrange, use spoken spells and {{Magical Gesture}}s to use their power. They can be incapacitated by anyone who can get them BoundAndGagged -- if not taken out first by a rush of tranquilizer darts they never see coming -- which has led most of them to learn the basics of self defense so they can protect themselves physically.
** SelfDemonstrating/{{Loki}}'s frequent cohort the Enchantress is one of the most powerful sorceresses in the Marvel Universe. Unfortunately, she needs her hands and voice to cast spells most of the time. Sturdy bonds and a gag are enough to do her in, as both the Frost Giants and Comicbook/DoctorStrange's partner Clea have demonstrated several times.
** DC's ComicBook/{{Zatanna}}, who activates her magic by speaking backwards, has the same problem. She's one of the DC Universe's top magic users, but, because she needs to verbalize her spells, she can be rendered helpless if she's made unable to speak, which led to her being frequently (especially in her early days) BoundAndGagged. Recent comics have come up with creative ways to work with this, such as a Batman comic where the Joker shot her in the throat so she couldn't talk, but she managed to write a spell in her blood. Perhaps due to the frequency with which she finds her sorcery rendered useless, Zatanna eventually started working out and taking combat lessons. She was even briefly able to hold her own in a fight against Comicbook/{{Catwoman}} after the villainess duct-taped her mouth shut.
* The BigBad of ''Comicbook/{{Sleeper}}'' has a great intellect and uses it to talk to his enemies and convince them not to fight him, or even to MindRape them. [[spoiler: Up until one of them ''rips his tongue out of his mouth.'']]
* When Mr. X joined the Comicbook/{{Thunderbolts}}, he bragged at length about being able to predict every move his opponents made based on a combination of low-level telepathy and reading body language. This served him well until he came up against Comicbook/{{Quicksilver}}. Suddenly, being able to predict his opponent's moves didn't help at all since he still wasn't fast enough to counter them.
* Sebastian Shaw can absorb kinetic energy to make himself stronger, making attacking him directly useless. He still needs to breathe, and Storm once made him run away by making the area so cold that he couldn't stand it.
* ComicBook/EmmaFrost eventually developed a "secondary" mutation with a new power (no, not [[MostCommonSuperpower that one]], she ALWAYS had that): being able to become living diamond, much like Colossus' organic steel above. Also much like him, she became NighInvulnerable, almost totally impervious to physical attacks, temperatures, etc. The downsides were that she lost her psychic powers (though she was also now fairly invulnerable to others'), and while she's yet to be actually "beaten down" the occasional writer remembers that diamonds are hard but they're ''brittle''. When struck properly her form cracks, and she was once [[LiterallyShatteredLives completely shattered]], needing the walking DeusExMachina known as the Phoenix Force to be put back together.
* The level of available oxygen affects the [[ComicBook/FantasticFour Human Torch]]'s powers. Thing has proven that super strong lungs can blow out Johnny's flame.
* [[SubMariner Namor]]'s dependency on water is this, given that his species is adapted to live underwater. Same can be said of ComicBook/{{Aquaman}} though his dependency on water depends on the writer.
* For a GreenLantern, anything that affects their concentration or undermines their resolve can weaken their effectiveness given that their power is directly dependent on their willpower.
* Franchise/{{Batman}} finally figured out a weakness for WonderWoman who has no WeaksauceWeakness. Her upbringing was high competitive and she won the right to represent her culture in man's world by winning a competition. Batman guessed correctly that her body would give out before she ever willingly gave up and came up with a way to force her into FightingAShadow.
* LukeCage has skin that is tough enough to resist explosions and any edged weapon up to something made of adamantium. This is good in a fight, not so good when he has internal injuries that can't be surgically repaired because of it.
* [[Characters/TheFlash Bart Allen]] had his kneecap blown off, and was rushed to a hospital. During the surgery his SuperSpeed meant that his flesh kept trying to heal improperly before an artificial kneecap could be placed, forcing the doctors to cut him open repeatedly. His metabolism meant that [[AndIMustScream no anesthesia could be used either]]. The same series reveals that he can't get tattoos; they "heal" in no time.
** For a time, Wally West (the second Flash) had his powers reduced to more "realistic" levels with some obvious drawbacks. His upper limit was about the speed of sound (any faster would tear him apart), he required massive amounts of calories to fuel his metabolism, and his uniform had to be made of special low friction materials (and required frequent repair and replacement). Eventually the "Speed Force" was discovered, which not only increased his powers to a level even greater than his predecessor Barry Allen, but also provided numerous RequiredSecondaryPowers to remove these weakness. He's still a BigEater, though, but it's because he wants to be.
* {{ComicBook/Taskmaster}} has the power to copy the skills and movements of anyone. However this doesn't grant him RequiredSecondaryPowers which can potentially render a copied skill useless; he once copied someone's diving abilities only to nearly drown when it turned out he hadn't bothered to copy the ability to ''swim''. His copying powers also overwrite his memories and own skills, as he still has the mental capacity of a normal person; not only has he forgotten how to perform some basic menial tasks but he's also forgotten most of his childhood, his ex-wife, and possibly even his daughter.
** And when up against Deadpool's random insanity, he can't predict anything and gets confused and beaten pretty quickly.
* [[{{ComicBook/Daredevil}} Daredevil's]] radar senses are pretty useful most of the time. Too bad they can become blurred and disorienting if there are too many objects around at once. Plus his strong senses mean he's sensitive to extremely loud noises. The movie depicts him as having to rest in a special soundproofed bed to get a good sleep.
* The [[UsefulNotes/TheSilverAgeOfComicBooks Silver Age]] DC villain Ten-Eyed Man was a guy whose "[[WhatKindOfLamePowerIsHeartAnyway power]]" was being able to see through his fingertips. Every single battle involving him ended with him being ''tricked into grabbing something'' causing him incapacitating pain. ''WesternAnimation/BatmanTheBraveAndTheBold'' {{lampshade|Hanging}}d this by having Batman defeat him by chucking a cactus at him. He was used as a one-shot villain in ''[[BatmanRIP Batman: The Black Glove]]'' and was defeated by throwing shrimp scampi sauce on his hands.
* Gagging ComicBook/BlackCanary could effectively disable her [[MakeMeWannaShout sonic scream]], despite the fact the Canary Cry theoretically should be able to break through any cloth. That too, has decreased in recent years, although Comicbook/{{Deathstroke}} found an, “[[DoesThisRemindYouOfAnything interesting]]” way to silence her in an issue of Comicbook/GreenArrow.
* Siryn from ''Comicbook/XFactor'' has a similar gag weakness. However, it's handled [[DependingOnTheWriter very inconsistently]]; in one case she was able to shatter a metal gag with low-frequency sonics, while a later story had her effectively neutralized by a strip of [[DuctTapeForEverything duct tape placed over her mouth]].
* Venus from ''Comicbook/AgentsOfAtlas'' possesses the same above-mentioned gag weakness. Luckily, she also has superhuman strength to compensate, so it takes a pretty powerful opponent to muzzle her in the first place.
* Songbird (formerly Screaming Mimi) from ''Comicbook/{{Thunderbolts}}'' is another vocal-based heroine who is rendered completely useless if she's gagged.
[[/folder]]

[[folder:Fan Fiction]]
* In ''Fanfic/MarieDSuesseAndTheMysteryNewPirateAge, Admiral Lance D. Imba, who can [[PowerCopying copy anyone else's Devil Fruit Power]] and has taken several fruits already with his Copy Copy Fruit, takes in Mar's Logic Logic Fruit power and dies because the new fruit forces his powers to obey the laws of logic, including the rule that a Devil Fruit user who eats another one will be killed. This also references a sometimes-mentioned fear that people have when eating Devil Fruits; that they will lose the SuperPowerLottery and trade their ability to swim for a useless power; in this case, the power Imba stole worked against him.
* In ''Fanfic/PerfectionIsOverrated'', the [=SUEs=], being [[ParodySue representations of Mary Sue archetypes]], fall into this from time to time.
** Mariko Suou's powers cause everyone she meets to consider her their most important person. As this includes the Himes, who fight with their most precious person's life on the line, Akane's defeat results in Mariko's death.
** Shizune's power enables her to completely nullify one person's ability and reduce the effectiveness of all others around her; if enough people are around her, all of their powers are virtually useless. This does not, however, work on mundane means of attack, [[spoiler:and Natsuki kills her with a handgun]].
* In ''[[https://www.fanfiction.net/s/8702285/1/The-Ninth-Sekirei-Pillar The Ninth Sekirei Pillar]]'', Naruto can only use [[SuperMode Sage Mode]] for a few seconds at a time due to being in the middle of a large city and there not being enough Nature Chakra present.
* In ''FanFic/{{Fractured}}'', a ''MassEffect''[=/=]''StarWars''[=/=]''VideoGame/{{Borderlands}}'' [[MassiveMultiplayerCrossover crossover]] and its [[FanFic/SovereignGFCOrigins sequel]], there's a minor bit of FactionCalculus going on, as follows.
** ''Mass Effect'' (Balanced) retains its usual strengths and weaknesses as written on this very page--kinetic barriers only work against physical ordinance, biotics have caloric intake requirements, and large ships become cumbersome.
** ''Star Wars'' (Powerhouse), being a "softer" universe, has much better shields (they block ''anything''), more powerful [[EnergyWeapon weapons]] and faster [[FasterThanLightTravel lightspeed drives]]. All this comes at the cost of huge energy consumption explained away through more advanced [[{{Unobtanium}} hypermatter fuel]] while averting EasyLogistics: if the fuel shipments stop, the Trans-Galactic Republic's LogicalWeakness bites it in the butt. When the largest Star Dreadnaught runs low on reactor power, actual energy conservation measures are shown (shutting down civvie comforts, pulling crew out of certain areas of the ship), which to races used to thinking the newcomers can do everything, makes them wonder if the new "gods" are mortal after all.
*** Exploited by Cerberus/JVLN/Sapiens' Shield: Out of power? Hello, here's our surprise attack going after [[AttackItsWeakPoint every open exhaust vent]] we can find!
** ''Borderlands'' (Subversive) is also on the [[MohsScaleOfScienceFictionHardness softer end of the scale]] and being less fleshed-out is open to vast OCStandIn for whole civilizations, companies, and planets. Its strengths are few (such as Sirens or Eridium) but they still play an important part. Sirens can be prone to [[FantasticDrug addiction]], both to substances and PowerHigh brought about by their abilities. Eridium turns out to be useful in various ways, but can be ToxicPhlebotinum in gas form and the runoff from processing it is none too pleasant either (despite making excellent coolant).
[[/folder]]

[[folder:Films -- Animated]]
* ''WesternAnimation/TheIncredibles'':
** Violet can be seen while invisible if you throw something other than her suit on her. It has to be her custom-made supersuit too. Her regular clothes stay visible when she vanishes.
** Frozone relies on the water in the air to use his ice powers. When he's in a place with no water, like an apartment fire, he's useless. He also sometimes needs to keep hydrated himself, needing to request a drink of water while held at gun point for his chance to escape.
* In ''WesternAnimation/{{Shrek 2}}'', Mongo (an 80 foot tall Gingerbread Man) is vulnerable to [[spoiler:becoming soggy]].
* Stitch of ''Disney/LiloAndStitch'' is super dense and while that gives him super strength and endurance, he can't swim.
[[/folder]]

[[folder:Films -- Live-Action]]
* ''Film/{{Unbreakable}}'': David Dunn progressively learns that he is [[SuperStrength awesomely strong]] and [[SuperToughness extremely durable]]. He also finds that he has the power to [[DetectEvil sense a crime a person has committed]] or is about to commit when he touches them. However, he has the realistic weakness of water. This makes sense, as water wouldn't be affected by hyper-immunity or strength but affect the lungs when drowning the same as any normal person's. Plus, since his strength and durability are the result of bones that are denser than a normal humans, [[RequiredSecondaryPowers he would also sink a lot easier]]. Additionally, it's a [[WhyDidItHaveToBeSnakes mental weakness]], since he has a crippling fear of water after he nearly drowned as a child.
* Bullseye manages to exploit Film/{{Daredevil}}'s [[SuperSenses Super Hearing]] by creating sufficiently loud noises during their battle.
** In the director's cut of the film, Daredevil's LivingLieDetector powers are fooled by a witness with a pacemaker.
* ''Film/XMenDaysOfFuturePast'':
** [[spoiler:So, the Sentinels are made of a "space-age polymer" and contain no metal, and Wolverine has no adamantium in his body anymore? No problem, Magneto just bends some metal into their bodies so he can still restrain and/or control them with his powers.]]
** The future Sentinels exploit several logical weaknesses in their battles with the future X-Men. [[spoiler: They deliberately focus firepower on Bishop and forcefeed him so much energy that it overloads him, use extreme heat and fire to negate Ice Man's powers, and after all the other X-Men are dealt with they focus on swarming Blink, attacking her from so many angles that she can't think to make portals fast enough. And of course as mentioned above they're made of an advanced polymer meaning Magneto has to fall back on using outside sources of metal to fight them, making it easier for them to take him on.]]
* In ''Film/TheAmazingSpiderMan'', the cold-blooded Lizard becomes sluggish and vulnerable when chilled.
* ''Film/SherlockHolmes'': the title character is a significantly less capable combatant without time to think about his moves and/or SherlockScan his opponent.
* In ''Film/TheLastAirbender'', since benders need their element to be present while they attack, firebenders need to set up sources of fire before fights (note that this is not the case in the show, where firebenders simply shoot fire from their hands). For some mysterious reason, none of the characters think to actually take advantage of this weakness by dousing the flames. Also, [[spoiler:Iroh's fighting near the movie's end implies that ''really'' powerful firebenders can overcome the weakness and generate their own fire.]])
[[/folder]]

[[folder:Literature]]
* In the ''WildCards'' books, Philip "Fadeout" Cunningham can turn invisible, but he can't see unless his eyes are visible (as, like anyone, his vision depends on light contacting pigment molecules in his retinas). Fortunately (for him) he can turn parts of himself invisible while leaving others opaque, so he counts on the fact that a pair of floating eyes are hard to spot at a distance, especially in dimly lit areas (plus, he can always make his eyes vanish if hiding is more important than seeing his surroundings).
* In ''Literature/CodexAlera'' furycrafters that work with one element can be disabled through relatively simple means. Aircrafters are covered in dirt, earthcrafters are suspended off the ground, watercrafters are dehydrated, firecrafters are placed in small spaces (so any fire cooks them alive), and wood/metal crafters are stripped of their respective elements. Disabling someone with multiple elements is trickier, but doable.
** The Vord Queen specializes in these, to the point where at any point where her enemies seem to be winning, she improvises (or already planned) a solution that nullifies her foes' advantage. At one point, when [[spoiler: Araris]] goes full-on ChromeChampion on her, she figures out a rather simple weakness, and coats him in ice, making the metal that makes up his skin extremely brittle and excruciatingly painful.
* One of the main limitations on magic in ''Literature/TheDresdenFiles'' (or, rather, the mortal magic, as werewolves and faeries seem to sidestep the issue) is that you really have to know what you're doing for something to work. You can't transform someone into a frog without knowing an awful lot about the anatomy of frogs... and if you don't want to destroy someone's mind in the process you have to really know neurosciences. So, essentially, it's impossible. Also banned because it's so dangerous.
** Not sidestep so much as displace; weres get help (through bargain, artifact or rituals of communion) from something which ''does'' know all of that, and some nonhumans such as certain faeries fall into that category. Their minds and senses simply give them complete and accurate knowledge of all of the details of the relevant natural processes; for them extrapolating from a strand of DNA to a creature's adult form, natural environment and group dynamics may be as simple as pluralizing a word... and requires no greater intelligence than the latter feat would for a human. This actually carries its own LogicalWeakness in that a being ''that'' aware of cause and effect is at base restricted by that awareness.
** As far as the shapechanging goes, this is demonstrated with Billy and the Alphas, who are [[OurWerewolvesAreDifferent one of a few varieties of werewolf]] in the series. The beasts they turn into are creatures that look like wolves to the casual observer, but wouldn't fool, say, a zoologist.
* The ''Franchise/{{Mistborn}}'' series follows a very strong MagicAIsMagicA system, so many powers can potentially be a double-edged sword. Someone burning tin (which gives SuperSenses) can be incapacitated with loud noises or flashes of light, for example, and to be any good as a Coinshot (telekinetic control of metals), you'd better have a ''really'' good understanding of elementary physics- try and Push something bigger than you are and you'll be the one flying across the room instead.
* The fact that the Church of God Awaiting doesn't know ''how'' the Charisian protagonists of ''Literature/{{Safehold}}'' stay one step ahead of them so consistently does not stop them from developing countermeasures against it. The Empire of Charis has access to technology far beyond the planet's MedievalStasis, letting them spy on just about anyplace they want. While simply assuming Charis just has damnably good spies, the Church works out their Temple is a blind spot and cut their troops fake orders sending them one place before changing at the very last second to throw off Charisian response. Zhaspahr Clyntahn also organizes a network of agents who no direct contact with one another to prevent spies from learning anything from an overheard conversation.
** The Church is also unknowingly aided by a SelfImposedWeakness of the Charisian leaders: they can't reveal their technology, so even if they do get wind of something before it happens, in many cases they can't respond to it much faster than they could if they were really dependent on a spy network and mundane communication and transportation technology, nor reveal that they know things that would be utterly impossible for normal spies to ever discover.
* DeflectorShields are prominent throughout the Franchise/{{Dune}} series, including [[BarrierWarrior personal ones]]. The catch is that a shield that keeps anything from touching you also keeps oxygen out of your lungs, meaning you have to calibrate it to let slow-moving objects in. This obviously includes knives.
* Creator/LarryNiven's "The Theory and Practice of [[TeleportersAndTransporters Teleportation]]" is full of these; one of the obvious-in-hindsight yet rarely-used is that teleporting into "thin air" would fill your body with lethal embolisms. Answer: Switch places with whatever's sitting wherever you're teleporting to. Of course, that "whatever" could be someone you're pursuing...
* The students in ''Literature/{{Idlewild}}'' are genetically engineered to have superhuman immune systems to protect them from disease. Those same immune systems go berserk when they encounter any unusual material. Considering how long the students spent in suspended animation, pretty much everything merits that allergic reaction.
** In the sequel ''Literature/{{Edenborn}}'' they discover that between the super immune response, [[ThePlague Black Ep]], and the drugs to treat it, [[SterilityPlague women are incapable of carrying a fetus to term.]]
* The original ''Literature/TheInvisibleMan'' pointed out a lot of these in regards to invisibility. For example, to actually be completely undetectable Griffin has to strip down until he's naked since his clothes don't turn invisible with him; this makes exploiting his invisibility more treacherous than ever when he ends up in a snowy mountain town as he could easily freeze to death. Griffin also notes that it's ''incredibly'' difficult to move around without making any noise, so the invisibility only works best when he remains completely still and doing that carries the risk of someone bumping into you.
** This is taken advantage of near the end, when Griffon is chasing someone with murderous intentions. The person, who had heard Griffon's entire story and thus heard of all his weaknesses, takes care to run over the most broken, sharp, littered areas of ground he can find, since he has shoes to protect his feet and Griffon has nothing.
* In the ''Literature/HeraldsOfValdemar'' series, someone comments that since it's difficult to cast spells without gesturing, the best way to disable a mage without risking killing him is to break his arms. He then demonstrates.
* Similarly, in ''Guardians of the West'', first book of David Eddings' ''Literature/{{Malloreon}}'', Garion takes the precaution of blindfolding a captured Grolim sorcerer. He reasoned, correctly, that a sorcerer cannot safely teleport without knowledge of his location. This proves true when Beldin removes the blindfold...and he promptly vanishes.
[[/folder]]

[[folder: Live Action TV ]]
* In ''Series/{{Sanctuary}}'', Will and Watson found Clara when she was invisible by turning on the sprinklers to get an outline.
* ''Series/TheSarahConnorChronicles'' reveals that Terminators can't swim - they're just too heavy (however they're still waterproof). It also reveals that they can be temporarily disabled by powerful electrical shocks, although they reboot themselves in a couple minutes. Also, they set off metal detectors.
* From ''Series/{{Heroes}}'':
** Elle Bishop generates electrical blasts. However, her electrical powers are usually focused outwards, and she's not insulated from her own blasts. So if she's coated in water and attempts to use her powers, she just ends up shocking herself.
** Claude, an invisible man, still has a heat signature and is thus able to be seen with infrared goggles.
*** As an aside, [[BadassNormal Noah Bennet]] [[CrazyPrepared presumably has an entire manual full of these.]]
** Matt Parkman, due to his telepathy, is somewhat more vulnerable to bright lights and loud sounds while using it. This makes sense, as he's not just hearing the sounds/seeing the flashing lights with his own senses, but also the senses of the people whose minds he is reading and thus his brain can't handle it all at once.
*** Noah Bennet shields his thoughts from Parkman's power by ''thinking in Japanese'', a language Matt can't understand. Which brings up FridgeLogic when you consider that it means that everyone else whose mind he read must have actually been [[ConvenientlyCoherentThoughts thinking about the specific information he needed, in full sentences, at the specific time he was reading their mind.]]
**** There is at least one episode where Matt is clearly shown to manipulate a guard into thinking about an embarassing detail that he then picks up through telepathy.
* In ''Series/StarTrekTheNextGeneration,'' Data, the android, has the standard weakness to electricity and electromagnetic radiation. He's also too dense to float or swim, although he can survive underwater. He's said to be able to serve as a flotation device, though it's possible that he's got some sort of damageable inflatable airbag.
* ''Series/TheXFiles'':
** In one episode, a LiteralGenie grants someone the power to become invisible. He has to strip naked to make any use of it, which he considers a small tradeoff, although it makes going outside uncomfortable. Even more uncomfortable: he promptly gets hit by a car because the driver didn't see him. A previous "beneficiary" of the genie's wishes ended up with an inhumanly large, ahem, [[GagPenis manhood]]. He then keeled over from lack of blood to the brain when he got excited. And the paramedics had trouble getting him through the door while he was lying on his back.
** In "Trevor," the titular con gains the ability to become intangible after [[LightningCanDoAnything being struck by lightning]]. While he has the ability to pass through conductive objects, destroying them in the process, he's powerless against non-conductive materials. He's eventually killed when struck by a car - he can phase through the hood, but not the windshield.
* An antagonist in ''Series/{{Angel}}'' had the ability of DetachmentCombat. He couldn't stay separated for too long or his parts would suffer necrosis from the lack of nutrients.
* In ''Series/{{Alphas}}'' it's pretty well established that with every alpha ability comes a weakness of some sort. In early episodes, the most notable was Rachel, who has hyper, [[Series/TheSentinel Sentinel]]-esque senses. She was initially shown to be able to enhance one sense at a time, but while she did so, she couldn't use her other senses. (While her vision or smell was enhanced, she could not hear the other characters when they spoke to her.) This is a great weakness, which makes all kinds of sense. However, the writers seem to be forgetting about this weakness, as in recent episodes, she's been using her abilities without shutting the rest down; her weakness these days seems to be the fact that ''everything'' is ''always'' cranked UpToEleven for her, which is actually less fun for your dating life than you would think. She even had them ''permanently enhanced'' recently, though she seems to be handling it better now than at first.
* In ''Series/TheLostRoom'' many of the Objects have amazing abilities but also have serious weaknesses.
** The Key can let you enter and leave the Room through any door anywhere in the world (and thus lets you travel almost everywhere) but it cannot be a sliding door and in order to open the door it needs a tumbler lock. If you're not careful, you can trap yourself.
** If you touch the Ticket you will be teleported just outside Gallop, New Mexico no matter where in the world you are. It's very handy for quick getaways and to dispose of attacker or people who simply annoy you. However, its owner kept teleporting himself to New Mexico whenever he handled it. He finally was able to cover enough of it in duct tape that he could handle it safely.
** The Comb allows you to stop time for ten seconds but when the effect ends you need to be perfectly still or you will suffer terrible motion sickness. The short duration of the effect means that you might have to use it repeatedly and your body will suffer the consequences.
* On ''Series/TheListener'', Toby's telepathy requires the subject to be actively thinking about what he wants to find out, often requiring him (or his partner) to deliberately prompt the target with a leading question or statement. He's also limited in that he can only read what the subject ''thinks'' is true, he can't read people with some kinds of organic brain problem such as those suffering from epilepsy, and he's encountered one genius-level criminal who can simply think too fast for Toby to understand what he's thinking.
* In ''Series/KamenRiderDouble'', the Utopia Dopant [[EmotionEater draws upon peoples' positive emotions]], granting him incredible power and making him able to suck the life out of an opponent effortlessly. Inanimate objects, however, ''have'' no emotions to drain, meaning that the series' BigBad gets manhandled by the same cute and [[MerchandiseDriven Toyetic]] {{Robot Budd|y}}ies that have been hanging around since Episode 1. In fact, one of the show's copious [[CrowningMomentOfAwesome Crowning Moments of Awesome]] is protagonist Shotaro blocking Utopia's powers with nothing more than his [[ItWasAGift dead mentor's]] CoolHat.
* In ''Series/BabylonFive'', when using telepathy to determinate what someone knows, it only reveals the subjective truth. When Lord Refa uses a telepath to mind probe Vir to find out about Londo's scheme, he didn't take into account the possibility of Londo lying to Vir. In the end, [[spoiler: he walks into a trap and gets torn apart by angry narn, who are understandably pissed considering he was the one who ordered the use of mass drivers on their homeworld, a war crime so severe, it even gets condemnation from the normally distant Vorlons.]]
* ''Series/BuffyTheVampireSlayer''. In "Fool for Love" Spike points out a crucial disadvantage Slayers have versus vampires. For all their SuperStrength and SuperReflexes, a Slayer still needs a weapon to kill a vampire, whereas vampires always have their teeth. He gains the upper hand over the Chinese Slayer (and Buffy, while relating the event) by taking advantage of their instinctive grab for the weapon at hand.
* ''Series/TheFlash2014'' has Shawna Baez aka Peak-a-boo, who can teleport anywhere as long as she can see the destination. Naturally, this means that putting her in a completely dark space makes her powers useless, allowing Barry to easily overpower her.
* ''Series/TokumeiSentaiGoBusters'': Ryuji (Blue Buster) and Yoko (Yellow Buster) both have logical weaknesses. Ryuji possesses SuperStrength, but is prone to overheating [[HeroicRROD and going berserk]] if he overexerts himself or is exposed to heat for too long. Yoko has strong and athletic legs, but requires a near-constant intake of calories via candy lest she becomes tired and sluggish. Hiromu (Red Buster) has a less logical weakness: freezing up when he is frightened, which wouldn't be an issue if not for his [[WhyDidItHaveToBeSnakes phobia of chickens]].
[[/folder]]

[[folder: Other Sites]]
* The Wiki/SCPFoundation often has this.
** One story has the Global Occult Coalition trying to deal with a paranoid schizophrenic who has the power to alter the speed of moving objects. One of the GOC operatives realizes that despite his powers, he still thinks at the same speed of a normal human. Said agent than manages to kill him by sneaking up and shooting him point-blank in the head; at such close proximity the guy wasn't able to think fast enough to slow the bullet before it killed him.
** [[http://scp-wiki.net/scp-347 SCP-347 ("Claudia")]] is a woman who's permanently invisible in the style of the original Invisible Man. She also suffers the same weakness as him; namely that to actually use her powers effectively she has to strip naked which can be fairly dangerous.
** [[http://www.scp-wiki.net/scp-492 SCP-492 ("Animated Cloth Dummy")]]. Because SCP-492 is made of cloth it is almost immune to physical attacks such as blows. However, its cloth body also makes it very vulnerable to flame.
** [[http://scp-wiki.net/scp-615 SCP-615 ("Stick Blob")]]. SCP-615 is made of a large amount of dead and discarded plant matter, such as leaves and branches. It can use its tremendous strength and bulk to engulf, crush and suffocate living victims. However, its wooden mass makes it very vulnerable to fire attacks.
** [[http://scp-wiki.wikidot.com/scp-692 SCP-692 ("Revives the Colours")]]. Clothing animated by SCP-692 is resistant to most forms of physical injury (such as blows, bullets and so on) because, like normal clothing, it isn't alive. However, like normal clothing it is vulnerable to fire.
** [[http://www.scp-wiki.net/scp-834 SCP-834 ("Marked")]]. The things that are created by a SCP-834 marker's ink can be destroyed by water because the ink that creates them is water-soluble.
[[/folder]]

[[folder: Tabletop RPG ]]
* Some of the Disadvantages of characters in the "{{Champions}}" superhero RPG were of this type. For example, the insect-like alien Insectoid took damage from exposure to the insecticide malathion.
* In both ''TabletopGame/VampireTheMasquerade'' and ''TabletopGame/VampireTheRequiem'', characters can buy a power that allows them to heighten and refine their senses. Of course, if there's a sudden change in sensory input (e.g., opening a storage locker to find a rotting corpse when you've got heightened smell up), you're probably going to be reeling.
[[/folder]]

[[folder: Video Games ]]
* Often occurs in ''Franchise/MassEffect'', due the [[MohsScaleOfSciFiHardness hardness]] of the universe.
** Spaceships use [[DeflectorShields kinetic barriers]] that allow deflection of debris and mass accelerator rounds, but only up to a certain point. As their name also implies, they're ''kinetic'' barriers, and thus only effective upon physical mass; laser-based weaponry can bypass them completely but has yet to be developed beyond defensive weaponry.
** Personal kinetic barriers are calibrated specifically to deflect small and high-velocity objects, but allow slower moving objects to go through ("so the subject can sit down without knocking away their chair"-gametext). This has led to special bullets that have different shapes and speeds than normal in order to be more effective against armor, as well as phasic and disruptor bullets that inflict part of their damage as electricity, which goes straight through shields.
** Biotics have powerful GravityMaster[=/=]MindOverMatter abilities, but with the exception of the Asari (due to their reproductive systems [[spoiler:and some Prothean genetic engineering)]], who have precise control over their nervous systems, any biotic who wishes to use their powers effectively have to have special implants. Also, since they use their own bio-electricity to fuel their powers, biotics who use their powers on a regular basis require greater caloric intake than normal.
** Thanks to the SquareCubeLaw, even with mass effect fields, the largest ships are unable to land on a planet. The SufficientlyAdvancedAlien Reapers can get around this, but are still quite awkward on the ground. In addition, this makes their kinetic barriers far weaker.
* Cole [=McGrath=] from ''VideoGame/InFamous'' is officially [[OverlyNarrowSuperlative the first protagonist of a sandbox game that can justify]] [[SuperDrowningSkills his inability to swim.]] (In fact, he IS able to swim for a very short while, and he's perfectly fine if he steps in a small puddle, although if someone else steps in the puddle shortly afterwards they won't be so fine.)
** Chain-link fences provide perfect cover from Cole's lightning for the same reason - electricity, by its very nature, follows the path of least resistance and gets grounded by those fences. Though one has to wonder why he can't simply climb the fence, especially since he's very skilled at LeParkour. Does the fence suck the electricity out of him?
*** His inability to climb fences seemed to be a limitation of the game engine, since he got over it in [[VideoGame/{{inFAMOUS 2}} the second game]]. His inability to shoot through metal fences, however, was shown to be completely diegetic, as he was rendered a sitting duck when he was trapped behind metal bars.
* In ''VideoGame/InfamousSecondSon'', Delsin Rowe has PowerCopying abilities that allow him to absorb the powers of other Conduits. Unfortunately, this means that he suffers from HowDoIShootWeb every time he absorbs a new powerset.
* Alex Mercer of ''VideoGame/{{Prototype}}'', due to the way his offensive and defensive abilties are set up, and the fact that [[IAmAHumanitarian he absorbs people]] and thus incorporates their mass into his own, is literally ''too dense to swim''. This is apparently true of [[spoiler: ''everything'' that gets infected with either Redlight or Blacklight and is mutated, given that none of them survive being pushed into the drink.]] Though he ''can'' jump off the bottom of the East River because he sinks nearly as fast as he falls, but then again this applies to everything in the game, infected or not. Anything not capable of jumping like that [[SuperDrowningSkills dies instantly on contact with water]].
** However, despite his immense mass he can still glide along a decent distance. No-one is quite sure how it works.
** In-game description states that he ejects biomass, propelling him in a slight upward trajectory. It also leads to some rather nasty [[FridgeHorror Fridge Horror]] about the infection.
* The ''VideoGame/MegaManClassic'' games often use this: Electric guys experience shorts when you stick a blade in them; fast guys are vulnerable to time stopping, and so forth. The Weapon Archive in ''10'' is a PuzzleBoss[=/=]FinalExamBoss that requires you to know your ''Mega Man'' history and ask "Which of my weapons is most like what beat this guy the first time?"
** ''VideoGame/MegaMan8'' has these for six out of eight Robot Masters. Clown Man gets tangled in his ridiculously-long arms if hit with Tornado Hold; Thunder Claw is the only safe way to [[PlayingTennisWithTheBoss bounce Grenade Man's bombs at him]]; Sword Man (who's fire-based) is left smoldering if hit with Aqua Balloon; Search Man lights on fire if you hit his bush hiding spot with Flame Sword; Astro Man, a neurotic (listen to his greeting), freaks out and can't move if you lock on with Search Missiles; and Tengu Man, a flying boss, is grounded by the Ice Wave (like how airplanes are grounded if their wings ice up). The exceptions are Aqua Man (weak to the Astro Crush) and Frost Man (blinded by the Flash Bomb, which doesn't have an obvious logic given he's AnIcePerson).
*** [[ShowsDamage The water tank on Aqua Man's head is shown breaking whenever he's hit by Astro Crush]], so it's likely he's running on a finite water source and doesn't want any more of his ammunition to spill out, hence why he spends a second or two mending it after taking damage.
** In some cases, though, it requires some advance knowledge of the boss to be able to figure out what to use. In the tenth game, why would Strike Man's weapon be the best to use against Sheep Man? Because the former uses the Strike Rebounder (which bounces around due to being a rubber ball) and the latter uses the Thunder Wool. There's also [[TransformingMecha Nitro]] [[CoolBike Man's]] weakness to the Chill Spike, similar to motorbike wheels getting punctured by spike strips. In fact, while every boss in ''VideoGame/MegaMan10'' has weaknesses that fall into this trope, most require knowing just what the boss does.
** In the games, if a Robot Master's main strategy involves abusing CollisionDamage, they will probably be weak to [[LuckilyMyShieldWillProtectMe shield weapons]] (3: Top Spin—which protects you while in midair—vs. Shadow Man, 6: Plant Barrier vs. Tomahawk Man, 7: Junk Shield vs. Freeze Man. The only subversion appears to be 2, where Air Man's best known for his tornado projectiles yet is weak to the Leaf Shield).
* ''VideoGame/MegaManX'' also uses this. Ice bosses like Chill Penguin, Frost Walrus, and Blizzard Wolfang can't stand fire (fire melts ice), while Fire bosses like Flame Mammoth, Magma Dragoon, and Burn Dinorex are weak to wind (wind blows out fire). The Boomerang Cutter can sever Launch Octopus' limbs, making him unable to use some of his most powerful attacks, such as twirling around to suck X in and using his tentacles to leech X's life. Using it on Flame Mammoth cuts off his trunk, denying him many useful abilities, including his signature Fire Wave, for the rest of the battle.
* John Marston from ''VideoGame/RedDeadRedemption'' can't swim. It makes sense since the character has spent most of his life in the WildWest, where there isn't a whole lot of water. The above ground water sources we do see are mostly fast moving rivers or dirty and swampy.
* Much of ''{{Pokemon}}''[='s=] ElementalRockPaperScissors falls into this. For instance, electrical attacks are stronger against Water-types because water conducts electricity while useless against Ground-types (think "grounding").
** This also applies to some other effects, such as how heavy rain will halve the power of fire.
** Grass-types are typically weak to bugs since most bugs subsist on plants.
** Why are Pokémon with the Water/Ground type combination doubly weak to Grass? Because most plants need water and soil (Ground) to live. Similarly, Rock-types have trouble with the eroding power of water.
** Dragon's weakness to Ice makes sense because dragons are typically reptilians, which aren't usually capable of controlling their body temperature. Grass-types can't tolerate cold temperatures very well, either - after all, cold temperatures can kill off plants.
** Poison's weakness to Ground. Ever been in a chemistry lab (whether it's one in school or not) where kitty litter-like substances are used to absorb chemical spills? And it's ''useless'' against Steel (think ''stainless'' steel, a possible ''container'' for toxic chemicals).
** Fighting does half-damage to Flying-types, because, well, it's [[http://www.awkwardzombie.com/index.php?page=0&comic=081610 kind of hard to punch a bird]] (and most birds are skilled at attacking their prey from above). It does ''no'' damage to Ghost-types, because ghosts are incorporeal. Then again, Ghost-types can't hurt Normals, either.
** Psychic is weak to Bug, Ghost, and Dark types, all common phobias. It's hard to concentrate when you're frightened.
** Fairy's weakness to Steel makes sense, considering the old legends that fairies are weakened by metal (specifically, cold iron). This same lore also shows them having power over Dragons (thus strong ''both ways'' against Dragons). Fairies are also commonly seen as symbols of pureness so are strong against Dark (natural guardians) and weak against Poison (taint).
** Ground does no damage to Flying, because it doesn't make sense to manipulate the ground while your enemy is hovering in the air.
** Ice and Rock are weak to Fighting. We've all seen those demonstrations where master martial artists use their hands, feet, and heads to break open blocks of ice and concrete, haven't we? Same with bending Steel.
** Grass is weak to Poison...why? Weed-killers and herbicide are made to get rid of plant life.
** Fighting is weak to Psychic, because of the old "brains over brawn" conflict. Also it's hard to hit someone when they're reading your mind and foreseeing your every move.
** Why is Psychic is strong against Poison? Either because the brain controls the immune system and can get rid of most illnesses and diseases (the "poisons" of the body) or it's symbolic of how common sense and learning can prevent poisonings from happening.
** Why is there a Dark element? Primarily to present a surreal element: something beyond the realm of normal thought and existence. Thus why the paranormal elements, Psychics and Ghosts, are its natural strengths.
** Why are Dragon- and Ghost-types strong against another of the same type? Basically, they're rare or strange enough that it takes one to know one.
* In ''{{Magicka}}'', while your characters are all {{Squishy Wizard}}s already, you can shock yourself if you use electricity while soaked.
* A stone based monster in ''VideoGame/FinalFantasyIX'' can be killed instantly by using a Soft on it, which is normally used on petrified allies. The game states that the monster "became too soft to live".
** There is actually an entire area of stone-based enemies that are susceptible to this tactic. The boss at the end is a reanimated petrified tree, [[{{TheDevTeamThinksOfEverything}} and can be instantly killed with Soft OR Phoenix Down.]]
* In ''VideoGame/{{Mother 1}}'', main character Ninten is an asthmatic, so anything that can trigger an asthma attack (like living cars belching toxic fumes at the party) will render him helpless.
* In ''VideoGame/SuperSmashBros Wii U/3DS'', Little Mac is an absolute beast when fighting on the ground, fitting for his BoxingBattler status; but the fact that he's a boxer means that his air combat is subpar at best, being barely able to land a punch or jump back to the battlefield.
* In ''Videogame/DigitalDevilSaga'', Earth attacks are "shielded" against by flying enemies; see the ''Pokémon'' Ground-versus-Flying example above. This is one of the few logical ''immunities'' in the series.
* ''VideoGame/SoulSacrifice'' describes the weaknesses of several Archfiends in their Librom entries. Quite a few of them make sense. The Harpy, as one example, was originally a massively overweight noblewoman; as an Archfiend, she's weak to fire because of how combustible fat is.
* In ''Franchise/AceAttorney'', Phoenix Wright is assisted in his quest as a CrusadingLawyer by his Magatama, an item allowing him to detect lies. [[spoiler: ExactWords can fool it. In fact, a villain truthfully said that he didn't kill the victim (he hired a killer to do the wet work instead, so technically he didn't kill anybody).]] In ''VisualNovel/PhoenixWrightAceAttorneyDualDestinies'', [[spoiler: The Magatama session with Bobby Fullbright (AKA, the Phantom) implies that the Magatama can also be fooled by carefully thought out cover stories and great acting.]]
* ''VideoGames/BioShock'' and its sequel are set underwater. Apart from the "one-two" punch of slugging Splicers while they're stunned from Electro Bolt, you quickly learn that shooting an Electro Bolt into a pool of water makes for a very effective attack against most splicers. The "most" qualifier notes another Logical Weakness: you can't use an elemental power against a Splicer already imbued with the same power. Thus electrified Splicers are immune to either application of Electro Bolt, and so on. Electro Bolt is also a logical attack to use against the electrically-powered defenses of Rapture (cameras, turrets, and bots), allowing you the chance to get close enough to hack them.
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[[folder: WebComics]]
* ''Webcomic/GrrlPower'', [[http://www.grrlpowercomic.com/archives/589 lampshaded and played straight]]: Being riddled with bullets. Oh, and Mittens.
** Sydney's shield is later shown to have the weakness of being ''so'' impenetrable that air cannot flow through it, thus rendering her lightheaded and eventually unconscious if she keeps it up for too long (though she does point out that it seems to have the RequiredSecondaryPowers necessary to keep her from being affected from the pressure changes that would normally result from changing the size but not allowing more air to enter or exit).
** [[FailOSuckyName For Whom the Death Tolls]] has the ability to counter any power thrown at him, but therefore not only has the weakness of not being able to do anything if no one attacks him first, but also can be overloaded if forced to counter too may powers at once since the counters will start to conflict.
** Heavenly Sword can create energy "blades" a weapon, usually a sword, but the weapon itself is still only as strong as the material it's made of, and if she doesn't have any weapon, she's just a normal woman.
* ''Webcomic/TheAdventuresOfDrMcNinja'' mainly runs of RuleOfCool and RuleOfFunny, but it does occasionally use logic. For example, a well-established danger of the organic jetpack is that its user can be driven insane by oxygen deprivation if they fly too high, too long. When [[spoiler:Frans Rayner]] comes back from the dead as a cyborg, his augmentations draw energy from his organic body (because he lacks an external power source), so firing his laser eye ''once'' leaves him too exhausted to do anything. And, according to one AprilFoolsDay comic, the [=McNinja=] family's one weakness is "Bullets. From a gun."
* ''Webcomic/{{Collar 6}}'' has a character who can use "rubbermancy" (think Bending from ''WesternAnimation/{{Avatar}}'' and you've got the right idea). She can instantly disable most people in the BDSM-themed world by turning their rubber clothing into instant bonds, but her power is useless if there's no source of rubber nearby.
[[/folder]]

[[folder: Western Animation ]]
* ''WesternAnimation/MyLittlePonyFriendshipIsMagic:''
** Unicorns are stated to have a small suite of spells related to their special talent that they can use well (outside of [[MindOverMatter telekinesis]]). This means that if faced with a situation where those spells aren't any use, they aren't much help.
*** In addition, even if a unicorn has an appropriate spell, they need to be able to concentrate to use it. Panic, sensory overload, bring manhandled etc. will render them unable to use spells. It has also been shown that even lightly hitting a unicorns horn will disrupt any spellcasting they are attempting.
** The Elements of Harmony are meant to represent ThePowerOfLove and ThePowerOfFriendship as condensed magic sources (so, literally, friendship is magic). This means that if the users of the Elements aren't in sync, or otherwise fighting with each other, they won't work. Discord used this to his advantage by [[MindRape corrupting the Mane Six]], preventing the Elements from stopping him.
* Megavolt on ''WesternAnimation/DarkwingDuck'' is an electricity based villain shorted out by water.
** The Liquidator on ''Darkwing'' is intimidated by "a common cleaning sponge" and (in a ShoutOut to John Kendrick Bangs' "The Water Ghost of Harrowby Hall") by being locked in a freezer, as well as by cement and pudding mix(!).
** Bushroot's plantlike body gives him a lot of advantages including extending arms and high resilience, but since it's plant tissue it's easy to cut. He is also vulnerable to weed-killer.
* Similarly, on a Creator/CartoonNetwork bumper, Jan of the [[WesternAnimation/SuperFriends Wonder Twins]] says "I could get beaten by a sponge! It wouldn't even have to be an Evil Sponge!"
* [=H2Olga=], a nemesis of the Crimson Chin from ''WesternAnimation/TheFairlyOddParents'' is defeated by an ultra-absorbent diaper.
* In ''WesternAnimation/SpongebobSquarepants'', the Dirty Bubble, archnemesis of Mermaid Man and Barnacle Boy, has them trapped by his "awesome surface tension." Spongebob inadvertently defeats him by accidentally popping him with a pencil while asking for an autograph.
* ''WesternAnimation/StaticShock'''s protagonist had electromagnetic powers that went on the fritz along with every other gadget in the world when there was a lot of sun spot activity.
** Static also defeated a water-based villain using an electric current, thus breaking the water down into its components (he even calls the process, electrolysis, by name).
** However being splashed by water can short out his ability if he's currently charged up.
** Being essentially a human capacitor, he was also unable to generate his own current and was sometimes on the verge of defeat until he could locate a power source. This aspect was not depicted as consistently as others, however, and became moot once Richie managed to cook up some super-batteries he could carry around.
* In Disney's ''Disney/{{Hercules}}'' series, a monster steals the powers from heroes and demigods. Hercules then realizes that some of the powers carry crippling weaknesses, such as bright lights interfering with super vision, and uses that to trip up the monster.
* ''WesternAnimation/AvatarTheLastAirbender'': Because benders channel their powers through martial arts, binding or paralyzing their limbs is an effective means of defeating or imprisoning them, though sufficiently skilled benders are able to get beyond this. For example, when King Bumi was locked into a coffin with only his face poking out, he was able to Earthbend fairly effectively using only his ''chin''. Then again, he is ''110 years old'' (really, not the HumanPopsicle 110-year-old that Aang technically is), so he's had a ''lot'' of time to master Earthbending with any part of his body.
** Both Earth- and Waterbenders have a wide variety of moves to choose from, but require quantities of the element to bend, giving them a disadvantage in ocean and desert environments respectively.
** Fire- and Airbenders always have their element at hand, but also have their own weaknesses. Fire requires stable breath control to use (making it easier to lose control or tire from using the element), is less effective in cold or at night, and lacks many defensive moves. Likewise, Air Bending has fewer offensive moves, and the culture surrounding it is quite pacifistic, making it especially difficult to finish a fight.
** Toph Beifong was born blind, but uses [[DishingOutDirt Earthbender]] [[ElementalPowers skills]] as a DisabilitySuperpower to [[MagicAIsMagicA feel vibrations]] in stone, compacted soil [[spoiler:and metal]]. This means she can't "see" things that aren't touching the ground and her "sight" is severely impaired if she's not in contact with her element - She is extremely apprehensive riding on Appa, gets a view comparable to static when on sand (though it ''is'' possible for earthbenders to control sand, and she has gained enough skill with it to create a mini Ba Sing Se out of sand in the first part of the series finale), and is seen having to hold onto her companions when traveling on a wood-built village. Traveling on a metal boat is bearable, but she throws up within minutes of boarding a [[spoiler:submarine]]. And in a world without Braille, she's illiterate. But if she's on an earthen surface, she can see all around her, even behind things. And none of this stops her from intercepting catapult weapons fired from another ship on water, though that may just be her inherent skill.
** With [[spoiler:Metalbending having become a full-fledged bending discipline by the time of ''WesternAnimation/TheLegendOfKorra'', the sequel series also shows the bending style's weaknesses: they are very susceptible to electric attacks due to using reels of metallic cord to attack with as well as the metal covered suits they wear. Their metal suits also make them vulnerable to powerful magnets built into special [[MiniMecha mecha-tanks]] used against them.]]
** Also in ''WesternAnimation/TheLegendOfKorra'' there is Ming-Hua, a waterbender without arms who bends water into tentacle-like appendages to compensate. While her control makes her a very hard opponent for any waterbender [[spoiler: a firebender can evaporate her arms if she doesn't have a water source to replace them from and keeping the water attached to her body makes her extremely vulnerable to electrocution by a firebender who can bend lightning.]] And of course, without her CombatTentacles, she doesn't have any arms, making her even less capable of defending herself without her bending.
** The combustion benders in both series use a special third-eye tattoo to channel their explosions. Attacking this point in any way can disrupt then powers.
* In ''WesternAnimation/ExoSquad'', Neosapiens are stated to have heightened senses. Early on in the show they flashbang one to great effect.
* The clones created by the copy machine in the ''WesternAnimation/GravityFalls'' episode "Double Dipper" are made of paper, so naturally they dissolve when doused with liquid.
** In "Sock Opera" Dream Demon Bill Cipher takes control of Dipper's body. But while Bill is all-powerful in the mindscape, being in Dipper's body makes him only as dangerous as, well, a noodle-armed twelve-year-old. The fact that Dipper had gone several days without sleep AND Bill had been purposely injuring the body to feel pain only compounds the problem, as Mabel is quick to point out when she and Bill!Dipper fight.
* ''WesternAnimation/TheMask'' often employed this, combined with RuleOfFunny - Putty Thing has been defeated by being mixed with Canola Oil, falling into the ocean and being tricked into entering a cement mixer among other things; and three villains who escaped a comic book were defeated by destroying the comic.
* ''WesternAnimation/{{Gargoyles}}'' made a point of mentioning in one episode that you had to see and hear a magical spell being performed on you to be affected by it. When Demona casts her spell to turn every human in New York into statues at night (broadcast via TV), the only ones left unaffected are the blind (like Hudson's friend Robbins) and those who didn't see the broadcast (like Xanatos and one random woman who everyone thought was crazy the following morning after she said she didn't watch television).
[[/folder]]

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