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[[caption-width-right:225:...oh, now you're just being [[LiteralMinded difficult]].]]

->"''Remember, genes are NOT blueprints. This means you can't, for example, insert "the genes for an elephant's trunk" into a giraffe and get a giraffe with a trunk. There '''are''' no genes for trunks. What you ''can'' do with genes is chemistry, since DNA codes for chemicals. For instance, we can in theory splice the native plants' talent for nitrogen fixation into a terran plant."''
-->-- '''Academician Prokhor Zakharov''', ''VideoGame/SidMeiersAlphaCentauri''

With LEGO Genetics, you can fiddle with DNA wherever you like, intentionally or accidentally, and all the cells will change overnight (if that). Just wake up and presto! Wings! Fur! Gills! Hulking muscles! Giant brain! Stem cells! You don't even have to eat the equivalent of your entire body mass to [[ShapeshifterBaggage create all those new body parts]]; the old cells just rearrange themselves like Franchise/{{LEGO}} bricks. That part is usually HandWaved if not {{lampshade|Hanging}}d.

Instances of genetics in media tend to fit the "dumbed down" perspective on genetics taught to middle/high schoolers. Condensed to a more basic level, curriculum often has it summarized as:

## "The genetic double-helix is like a twisting ladder"
## "The rungs are nucleobases Adenine, Cytosine, Thymine, and Guanine"
## And "They are paired A to T, and C to G".

Since reality can be boring and [[CriticalResearchFailure writers can't be bothered]], you can expect [[TelevisionIsTryingToKillUs a great deal of frivolity]] in the media, with writers either fitting the above concepts or bending the plot ''further'' from accuracy. As such, expect scenes where patients [[EvolutionaryLevels "evolve" or "devolve"]] by [[ILoveNuclearPower radiation exposure]] while [[MrExposition an expository scientist]] throws around TechnoBabble near graphics of a spinning, [[PowerGlows glowing]] double helix.

It should be noted, however, that gene therapy, which involves the alteration, addition or removal of existing genes in an adult organism, [[TruthInTelevision really does exist]], but it's currently not permanent in most cases. [[ScienceMarchesOn They're working on that, though]]. The [[https://en.wikipedia.org/wiki/Hox_gene Hox genes]] are also an interesting reflection of this trope in real life, as these primitive "blueprint" genes do in fact seem to serve as the legos the genome uses to assemble a body, whether that be a spider, a bird, or a llama. See the Analysis page for more on those.

In fictional media, look for characters ending up an {{Animorphism}} or a HalfHumanHybrid because GeneticEngineeringIsTheNewNuke. Related to ChemistryCanDoAnything and MagicGenetics. See also: NoBiochemicalBarriers, UnstableGeneticCode, and BioAugmentation is a likely application.

For a more realistic, in-depth discussion, see [[Analysis/LegoGenetics the analysis sub page]].



[[folder:Anime and Manga]]
* The logic of Cell's creation in ''Anime/DragonBallZ'': he is a unique life form created from the combination of DNA from the strongest people to have been on Earth, such as Goku, Vegeta, Piccolo. Furthermore, he's born [[GeneticMemory knowing all their techniques]] and possesses all of their strengths. His DNA is formed from at least 4 species (Human, Sayain, Namekian, whatever Freeza and his father are) if not more (the various soldiers Freeza brings), and whatever splicing his creator performed, allowing him to regrow lost limbs, get stronger from his life threatening injuries and survive the vacuum of space. It is worth noting however that part of his creation involved dozens on tiny cameras filming the various battles the main heroes have, learning their fighting styles and then collecting their genetic material. Cell also says that a lot of information (including prerecorded messages from his creator) was fed to him during his incubation stage, which explains how he knows the various moves and techniques he does
* An episode of ''Anime/CowboyBebop'' had a villain attempt to deploy an airborne virus that rewrote DNA and turned those exposed into apes. The transition time seemed to be a couple days, tops.
* ''Manga/{{Naruto}}'':
** Sort of justified with Yamato's backstory: Orochimaru wanted to recreate the First Hokage's unique powers over the bijuu, so he spliced Hashirama's DNA into that of sixty infants. This was kept within the same species, so it was not too far into the realm of lunacy, but ultimately Yamato was the only success. The other fifty-nine infants died.
** Using Orochimaru's research, [[spoiler:Danzo apparently spliced some of Hashirama's DNA into his right arm. While the resulting flesh was able to grant Danzo control over the Sharingans he had also implanted in his arm, the tissue was near-cancerous in behavior. The arm was either sealed with a heavy metal lock to control the tissue or fed a constant stream of chakra to keep the tissue in line]].
* An episode of ''Manga/KimbaTheWhiteLion'' has the MonsterOfTheWeek being a winged tiger who grew wings from a hawk's nerve that's been implanted surgically by a scientist.
* ''[[Manga/MobileSuitGundamSeedAstray Gundam Seed VS Astray]]'' has a bizarre application with its "Carbon Humans". These guys are psuedo-clones of other people created by splicing another person's DNA into an ordinary human, then giving them that person's memories via some form of brainwashing. They can even have multiple genomes spliced in. The series makes it very clear that these guys are ''not'' clones, though really the difference isn't too great.
* Used in ''Manga/KnightsOfSidonia''. To deal with food shortages, humans have been given the ability to photosynthesize, even without any chlorophyll. To deal with decimated populations, a third sex has been created that starts out intersex, but will change to male or female based on [[SexEqualsLove sexual attraction]].

[[folder:Comic Books]]
* A good number of modern {{superhero}}es get their power this way, including the most recent incarnations of ''Franchise/SpiderMan''. [[WesternAnimation/SpiderManTheAnimatedSeries The '90s animated series]] tried desperately to justify and {{handwave}} this issue away by explaining that everything was caused by "Neogenics", a new genetic science that essentially used [[TransformationRay ray guns]] and [[ILoveNuclearPower magic radiation]] to create LEGO Genetics. In other words, you'd put animal DNA in one part of a ray gun and shoot the gun at a man to get The Scorpion. Really. And of course, if a spider accidentally got into the Neogenic Recombinator's beam, and soon bit someone...!
* Has happened both ways when Creator/MarvelComics mutants have lost their powers. Sometimes they transform to human; sometimes they keep physical changes such as a tail or wings. But then, most lost their powers when a powerful [[RealityWarper reality-warping]] ComicBook/ScarletWitch said "No more mutants..." and the results varied even then: some become completely human, some retain their altered appearance but have no powers, and a few who had physical mutations that disagree with the laws of physics lost [[RequiredSecondaryPowers whatever made it work before]]. (A long-necked woman's neck snapped and killed her, Chamber's "energy furnace" disappeared, leaving him without multiple internal organs, a GiantFlyer fell from the sky.)
* Longtime ''Comicbook/XMen'' character Longshot is an other-dimensional ArtificialHuman created by the Spineless One scientist Arize. To make matters even more interesting, many of Longshot's genes were taken from [[spoiler: his biological son Shatterstar, who due to TimeTravel had been sent into the past, where Arize discovered and used him in his experiments, thus making Longshot part of a StableTimeLoop wherein he is the father of his own [[MyOwnGrampa "father"]]]].
* All over the place in ''UltimateMarvel''. Most ridiculously, TheWasp once injected herself with a genetic SuperSerum and within ''seconds'' gained the ability to grow 60 feet tall.
** UltimateMarvel at least tries to ''explain'' its scientific flim-flam. The Wasp and her husband put years of effort into the serum. Of course, it started out with sixty feet being the limit because the human skeleton would snap apart after that. This was quickly abandoned for the RuleOfCool.
* ''Comicbook/{{Transmetropolitan}}'' used this with the tempers, and later the transients, to graft animal traits onto themselves. The former usually "wear" animal traits for a day, such as becoming part-dolphin to swim in the ocean with dolphins, and the latter took on alien DNA to establish a new identity. People also can slap on skin patches that give them new DNA traits, such as immunity to cancer (in this case, from smoking).
* Evil geneticist June Covington of the ComicBook/DarkAvengers developed a system of genetic 'plug-ins' that modify a person's genetic code. She experimented on herself to gain [[PoisonousPerson lethally toxic blood]] and the [[BreathWeapon ability to breathe]] DeadlyGas, plus joints that easily dislocate and a heightened pain threshold. It's implied that she gave ComicBook/NormanOsborn a few genetic boosts as well.
* In Brian Azzarello's (of ''ComicBook/OneHundredBullets'' fame) ''Spacemen'', UsefulNotes/{{NASA}} genetically engineered a few abnormally strong humans, resulting in [[CreatingLifeIsBad NASA getting abolished]] and the FantasticRacism the main character have to face.
* The Blood (later known as Bar Sinister) from ''ComicBook/ShamansTears'' were artificially created human/animal hybrids; each designed to have specific traits from the animal side (wings on the bat hybrid, prehensile feet on the monkey hybrid, etc).
* In ''ComicBook/AlbedoErmaFelnaEDF'', and finally explained by WordOfGod, this is the way how the anthropomorphic population was created [[spoiler:by creating genes from scratch and creating a being who looks like a human with animal features along the way]].

* The remake version ''Film/TheFly1986'' averted this with the malfunctioning transporter, while [[Film/TheFly1958 the original 1958 movie]] stepped right in it; Brundle's DNA has been changed, but the process is a lot slower due to the fly's lower biomass. He gradually becomes a sickly, deformed human-fly hybrid creature as his cells grow, instead of popping out half-fly instantly as he did in the original. In fact, the first thing that shows the beginning of his mutation is the appearance of a strange looking fleshy hair growth in a wound on his back which he got before the failed teleportation.
* ''Film/DieAnotherDay'' combines this with MagicPlasticSurgery.
* Done in ''Film/TheRelic''. A retrovirus found in prehistoric plants horribly alters the victim's DNA by inserting genes from past victims. The reason why there's a dinosaur ape-thing running about in the Museum of Natural History is because these plants could only ease the constant pain and insanity of the affected, since, you know, forcibly altering someone's DNA isn't going to have pleasant results. A later character is able to use rabbit DNA to make a safe street drug, basically a mild version of crack with no downs or life-threatening brain holes.
* In ''Film/JurassicPark'' the dinosaurs had frog DNA spliced in to fill in the gaps in their genomes caused by 65 million years in a mosquito's stomach. This allows them to change sexes like some frogs and breed.
* In ''Film/JurassicWorld'' the new park has learned not to use frog DNA this time, but the ''Indominus Rex'' is a MixAndMatchCritter made "mostly" from ''T. Rex'' genes but also a classified mix of half a dozen other species of dinosaur and modern day animals. Horns and spikes from various dinos, raptor arms [[spoiler: and communication]], cuttlefish genes supposedly for accelerated growth but also give her ChameleonCamouflage...
* ''Film/{{Underdog}}'' takes this trope to its logical extreme. Shoeshine is injected with a "serum", with contains genes for the wings of an eagle and the strength of an elephant, thus giving Shoeshine his abilities ''with no visual changes!'' And later in the film, he [[spoiler:is forced to give up his powers. They turn into blue pills. He gets them back when he eats one.]]
* In ''Film/Gremlins2TheNewBatch'', the gremlins find a genetics lab in the corporate office building and drink the genetic material, including, female DNA, spider DNA, bat DNA, and, uh, [[TheyJustDidntCare lightning DNA]] and gain the associated traits. Then again, what with the already questionable biology of the Gremlins, viewers could care less at this point.
* Deadpool, in ''Film/XMenOriginsWolverine'', is [[spoiler: fused with the DNA of dozens of mutants to gain their powers and become Weapon XI]].
* The human protagonist in ''Film/{{District 9}}'' is sprayed with a chemical (nanite solution) that gradually replaces his human flesh with alien anatomy over the course of a few days. At one point his body is described as being a genetic hybrid.
* ''Film/TheAnimal'' has the protagonist implanted with various animal parts, obtaining their instincts.
* In the first ''Film/SpiderMan1'', Peter Parker is bitten by a genetically-altered spider and develops super-strength, "SpiderSense," and the ability to climb walls among other {{Superhero}} powers ''overnight''. In the display room where he got bitten by the spider, we see a plasma screen showing the bits of DNA added to the spider to create the "super-spider." Later, there is a CGI sequence in which we see the rungs in the DNA double helix changing to the exact same colours as the spider's. Though it might help to not look at the CGI shots as literal, but more a creative way to show the audience what's happening quickly.
* In the ContinuityReboot of the series, ''Film/TheAmazingSpiderMan'', Dr Connors and Peter Parker develop the serum that turns the former into The Lizard this way. There is talk of "cross-species genetics" (the correct term is "transgenesis), and someone makes a joke that a woman injected with zebra fish DNA to cure Alzheimer's would have to look past "the gills on her neck". This is combined with ExtremeGraphicalRepresentation with DNA represented by little blocks in a holographic interface.
* ''Film/{{Sharktopus}}'': The government stuck the head of a shark onto the tentacles of a very, very large octopus.
* ''Film/TheThing1982'': It seems that the Things can do this [[ShapeShifter instantaneously, both at will and by instinct]]. It allows them to sample and utilize the genetics of any creature they come into contact with, and to form [[BodyHorror hybrid forms]].
* ''Film/MissionToMars'' plays with this trope. One astronaut painstakingly constructs a double helix out of M&M candies in zero-G. When another astronaut asks him what it is, he replies, "the perfect woman." The second astronaut reaches in and takes one of the candies, scattering several of the rest, and asks, "what is it now?" The first astronaut looks at it, puzzled, and says, "a frog?"
* If it's a ''Film/SyFyChannelOriginalMovie'', animal genes can often be injected into people willy nilly to create part-human hybrids like Mansquito, Sharkman, or Snakeman. This is also the usual explanation for the MixAndMatchCritters.

* "The Man Who Evolved" by Edmond Hamilton (1931), reprinted in ''Before the Golden Age'' edited by Creator/IsaacAsimov, is probably the UrExample (or one of them at least). The protagonist, before his friends, uses concentrated cosmic rays to "evolve" in a few minutes to successive stages of human evolution (each an improvement on the last). The story ends when he decides to "evolve" one last time, to the final stage of human evolution. [[spoiler:This turns out to be [[{{Irony}} the primaeval slime from which the human race first evolved.]]]]
* In ''Literature/MaximumRide'', the main characters are [[HalfHumanHybrid human-avian hybrids]]. Through years of genetic experimentation, they received powers specific to each character (such as mind reading for the resident EnfantTerrible) and in later installments would undergo random mutations that would give them [[NewPowersAsThePlotDemands powers that would conveniently tie into the story's plot]] and quite a few that don't.
* In ''Literature/DoraWilkSeries'' magic is genetically inherited through recessive genes, which author handled quite resonably... except for the main character, who has ''only'' recessive genes where there was choice (highly improbable in real life), giving Dora some [[CommonMarySueTraits mary-sueishness]], although narrator lampshades how improbable it is.
* Spoofed in the ''Literature/{{Discworld}}'' novel ''The Last Continent'', in which the God of Evolution explains that he was hoping to make the burnt offerings more efficient by finding the instruction that tells a cow to be soggy, and replacing it with the instruction that tells a tree to be flammable. It doesn't work, although in the way it ''really'' wouldn't work: he ends up with a bush that produces milk and makes distressed mooing sounds.
** And cows that would, on hot days, in certain rare circumstances, spontaneously combust and burn down the village. But is that any excuse for ingratitude?
* ''Literature/SpeakerForTheDead'' reveals that the alien "Descolada" virus caused this effect on the native life forms of the planet Lusitania, resulting in plants and animals literally giving birth to each other.
** And then in the next book, ''Literature/{{Xenocide}}'', a modified version of the virus is used to cure Path of its OCD problem in two days. Handwaved by the suggestion that the descolada replaces parts of its victim's DNA with random code (in the case of the descolada on humans and Formics) or a preprogrammed code (in the case of Lusitanian life and the humans on Path) so fast that the body cannot reject the modified cells fast enough before the body sees it as its own.
** The Descolada is explained as "ungluing" the DNA double-helix into two separate strands. This is fatal to humans and most other organisms but essential for the cellular reconfiguration involved in the life-cycle of Lusitanian lifeforms in their transition between plant and animal stages. Basically, it's an extremely aggressive and complicated viral-molecule that goes around trying to make Lego Genetics work on any DNA it encounters; the handful of surviving species on Lusitania have evolved such that they are resistant to the random insertion of DNA while depending on this process to enter the reproductive stage of their lives. Once this is understood, it becomes a convenient vector for quickly (as in almost overnight) removing the artificially introduced OCD-genes on the planet Path without sacrificing the super-genius genes these were attached to. A "neutered" version of the Descolada is also created in order to make it safe for Lusitanian and other life-forms to share a biosphere; the new molecule performs the necessary functions for Lusitanian life but will not infect (or mutate to be capable of infecting) other life forms.
* Creator/GregBear ''loves'' this trope. There is ''heavy'' LEGO Genetics work in the ''Literature/TheWaySeries'', ''Literature/BloodMusic'' and ''Literature/HullZeroThree''.
* In Creator/OrsonScottCard's ''[[Literature/TheTalesOfAlvinMaker Alvin Maker]]'' series, at one point young Arthur Stuart, the child of a runaway slave, is being tracked so his owner can reclaim him. The trackers are using magical ability to follow him via his genetic code: they have a lock of his hair, and this allows them to find him anywhere. Alvin's solution? He ''rewrites Arthur's entire DNA so it doesn't match the sample. By concentrating really hard.'' To get around the problem of Arthur's cells dying too quickly to be replaced, he dunks the kid in a river and then "orders" all the cells to adopt the new DNA simultaneously. The only negative effect this has on Arthur is that he loses his ability to mimic others' voices perfectly.
** Mind you, in some ways, this is more acceptable than many other examples. Alvin picks a few spots in Arthur's DNA and changes them to match his own, rather than make random changes or try to give him frog DNA or something. And this doesn't magically give Arthur Alvin's not-inconsiderable range of powers, either, which is a miracle in and of itself given the rest of this page.
* Octavia Butler's ''Literature/LilithsBrood'' trilogy is centered around the Oankali, an alien race that is capable of probing and sequencing genes on an instinctual level and that flies around the galaxy engaging in "trade" of gene sequences -- whether their partners want to or not in the case of humanity. Naturally, they have ''impressive'' abilities to meld the traits of wildly divergent species.
* The CDF's genetically engineered SuperSoldier bodies in ''Literature/OldMansWar'' are stated to blend DNA from a variety of sources, including aliens. However the mixture of genes makes them all sterile, which may have been intentional as it gives recruits an incentive to defend humanity instead of trying to replace it.
* Specifically averted within ''Literature/TheMoreauFactor'' with a thorough explanation of how pleiotropy makes Lego genetics impossible.
* This is how the virus worked in Dan Brown's ''[[Literature/DanBrownsInferno Inferno]]'' works. Just let the virus inject its DNA into the host's cell, and voila, a third of the human population is rendered infertile. More acceptable then other examples, however.
** Justified in that it's surprisingly easy to use a virus to produce infertility, because your gamete cells are genetically different from your somatic cells (the rest of the cells in your body). Your immune system has specific overrides to ''prevent'' itself from attacking your gametes and rendering you infertile. Bearing in mind that it's always easier to break something than to build something, it's relatively easy to make a virus that disrupts this override mechanism, and then your own immune system does the rest. This process is called "immunosterilization", and it was [[http://www.aphis.usda.gov/wildlife_damage/nwrc/symposia/contraception_symposium/tyndale_biscoe.pdf used very recently by Australian scientists]] to get their wild rabbit (an invasive species) population under control.
* ''Amazonia'' by JamesRollins revolves around a [[spoiler: tree which is implied to be the source of the Garden of Eden myth. I lures animals into its roots where it keeps them alive indefinitely while playing around with their DNA and using it to modify other animals including humans.]] Among its creations are piranha-frogs, super-sized caiman, intelligent jaguars, poisonous ant-wasps, and [[spoiler: a tribe of slave humans.]] The catch? [[spoiler: it knew humans had free-will so it programmed their changes to be unstable, without living near the tree and eating its fruit]] the changes become a virulent and highly contagious cancer.
* Completely subverted in {{Literature/Dopamine}}. The genetic engineering behind the MacGuffin is handled with painstaking realism, including the problems involved with restriction enzymes, plasmid uptake, and the need to use an indicator mechanism. Julie Yen even says at one point, "There's no such thing as a gene for [[spoiler: cocaine]]."
* This is what diverges ''Literature/{{Leviathan}}'' from real history, because, when Darwin developed the Theory of Evolution, he also discovered DNA. Fifty years later, as the world gears up towards WorldWarI, London has fabricated elephants instead of cars, gecko/parrot hybrids are used to send messages and the Entente armies liberally use FabricatedAnimals to fight the Central Powers' [[SteamPunk giant]] [[HumongousMecha Walkers]].
* Averted in ''Literature/{{Fearless}}'': Gaia undergoes relatively realistic gene therapy (described above) to replace her missing "fear gene" and, just like in RealLife, the effect is temporary. The only bit of ArtisticLicenseBiology is, of course, that there is no such thing as a fear gene. Many genetic and biochemical factors are involved in the experience of fear.

[[folder:Live Action TV]]
* The various ''Franchise/StarTrek''s do this at least once a season. It is interesting to note that "DNA resequencing" is a very common medical practice for treating genetic illness within the Federation, but they have strict NoTranshumanismAllowed laws due to humanity's experiences with the Eugenics Wars.
* It's hard to imagine that ''Series/StarTrekTheNextGeneration'' episode "Genesis" will ever being outdone as it involves the entire ''crew'' undergoing this... a cat becomes an iguana, one crew member becomes a snake, a fish becomes a jellyfish, and Lt. Barclay becomes a spider. I mean, that's a jump somewhere around the superphylum level.
* ''Series/StarTrekVoyager'':
** In the episode "Lineage", B'Elanna, half-human[=/=]half-klingon with issues, is upset to discover that the baby she is pregnant with by her human husband Tom has some klingon facial features, since those traits are dominant and can take generations to breed out. She attempts to forcibly reprogram the Doctor to genetically remove the klingon features in utero while performing resequencing to fix a spinal issue. Tom and the rest of her friends are appalled.
** A previous episode also had B'Elanna's DNA Lego disassembled - a Vidiian doctor separated her Klingon DNA from her human DNA, and built two separate and (basically) functional B'Elannas out of them.
* ''Series/RedDwarf'', never one to take science seriously, has the crew discover a LEGO Genetics device in the episode "DNA". It turns Lister into a chicken, a hamster, and eventually a one-foot-tall Robocop ripoff. They resort to the last one because the crew had ''turned a vindaloo into a half-man half-curry hybrid.'' It also inexplicably turns Kryten - a mechanical droid - into a human being simply due to the presence of a bit of organic matter in his brain.
* ''Series/{{Jekyll}}'' has TheMenInBlack rushing desperately to find the main character, because each time he transforms from his Jekyll persona into his Hyde persona (which he can do in less than a minute) his entire genetic structure is apparently changed. This is doing untold amounts of damage, and giving him only a few months to live.
* ''Series/StargateSG1'', "Bane": Teal'c is injected with alien bug DNA and starts mutating not even into a single bug, but into several of them at once. Not that the resolution was any better than the "science"... This might be reasonable if the bugs were parasites using him as a host but as they are claiming to alter his body by changing his DNA, they fail biology forever.
* The main villains of ''Series/StargateAtlantis'' are a result of LEGO Genetics; a life-sucking Iratus Bug mixed human and/or Ancient DNA with its own, and produced the Wraith. Our Heroes have developed a retrovirus that is capable of discriminating between the two genetics, and by separating them, "purifying" the subject to entirely human or entirely Iratus bug. [[spoiler: And in the Season finale series of season 4, we discover that a character has been able to modify the virus to add Wraith DNA to pure humans.]] Truly LEGO Genetics at its purest; take a little from column A and a little from column B at will. One wonders why the humans in the Stargate universe haven't started ad-hoc mixing of their genes from Earth creatures for their own advantage; surely the military could use some Marines with some grizzly bear genes and some tiger and some lion genes... oh my, that's a powerful soldier.
* ''Series/DarkAngel'': The protagonists (and some antagonists) were genetically modified with the traits of various animals. The earlier versions look like hybrids, the later versions look fully human but still have various animal traits.
* In the third season of ''Series/{{Sliders}}'', the writers lampshaded the change in Colonel Rickman's appearance (caused by the change in actors from Roger Daltrey to Neil Dickman) by stating that he absorbed the DNA of his victims whenever he injected himself with their spinal fluid. This was played further in the episode ''This Slide of Paradise'', when the only people available for Rickman to steal fluids from were the animal/human hybrids created by Dr. Moreau Vargas. Rickman, by the time the episode starts, has become somewhat feral, as a human/human/animal hybrid. Or something. Pretty bad, even by Season 3 standards.
* ''Series/{{CSINY}}'' featured some genetically engineered goats which produced spider silk (see RealLife below, if that sounds crazy).
* ''Series/{{Fringe}}'' featured a manticore-like creature formed of Gila monster, tiger, scorpion and a couple others. It could also infect people with its larvae through its stinger, an ability not shared by any of its composite creatures. Apparently this was all made possible by splicing in bat DNA.
** One of the animals used was a wasp. Some wasp species' larvae eat their way out of hosts in a similar fashion.
* ''Series/DoctorWho'' featured the Krillitanes, a race that absorbed biological components from the species it conquered. When the Doctor last met them, they looked like humans with long necks; when he meets them again, they're bat-like creatures.
** ''Series/DoctorWho'' is quite fond of [[MagicGenetics handwaving stuff by gibbering about DNA]]. Another good example is the Dalek that "regenerated itself" by "feeding off the DNA" of a time traveler. In the process, it absorbed said time traveler's DNA and thus became part human, giving it human emotions.
** [[spoiler:River Song, AKA Melody Pond, has Time Lord DNA despite the fact that her parents, Amy and Rory, are human. This is a result of being conceived in the TARDIS and exposed to the temporal schism.]]
** Evolution of the Daleks. Oh my ''God'', Evolution of the Daleks. When [[spoiler:the Dalek-Humans]] are created, they all look completely human; this does, however, make them ''think'' like Daleks, [[spoiler:except not, because the Doctor's DNA got mixed in]] by being too close to the freaking power source . . . Interestingly, the Daleks are a classic case of this trope and HollywoodEvolution. Their ancestors, the Kaleds, were HumanAliens, who suffered mutations due to the rigors of life in a ForeverWar, and were subsequently re-engineered into StarfishAliens by a crazed EvilutionaryBiologist. So technically, by trying to become more humanoid they were actually moving ''back'' towards what their species originally was.
** And then of course there's the fact that the Doctor can survive being extremely close to dying by COMPLETELY REWRITING HIS GENETIC STRUCTURE IN SECONDS.
** In "The Lazarus Experiment" Professor Lazarus' project to turn himself young again [[GoneHorriblyWrong goes horribly wrong]] and makes his DNA unstable, causing him to turn into a giant scorpion with a human head that feeds on the life force of others.
* An early episode of ''Series/{{Farscape}}'' had a villain making use of this trope - his plan was to stick Pilot's DNA into Aeryn, wait for her to develop Pilot's multitasking ability, and then somehow take it out of her and add it to himself. And this wasn't the first time he'd done something like this.
* In the ''Series/BeautyAndTheBeast2012'' reboot, Vincent transforms into a "beast" because of being injected with a serum that was supposed to make him a super soldier--said serum was a cocktail of animal DNA. The characters also frequently say he or his DNA is "evolving," ignoring the fact that that's not what that word means at all.
* [[https://www.youtube.com/watch?v=hV2w0YZRjBs This cholesterol medication commercial]] suggest you can get bad cholesterol genes from your Aunt Betty. If Aunt Betty is directly giving you genes, weirder things are going on in your family than high cholesterol. You may want to talk to your dad.

* In Music/DavidByrne's song "Self-Made Man", the characters literally swap chromosomes like they're baseball cards.
-->Well I'll trade you my potential mental illness\\
for your bad teeth.\\
How about trading your sexy body\\
for a full head of hair?

[[folder:Professional Wrestling]]
* Dr. Cube created Grudyin in Wrestling/KaijuBigBattel using gorilla and angler fish DNA; the end result is pretty creepy looking, though for some reason he has large, pointed, protruding nipples. Tucor was created via a similar process, but this time using two animals that are hard to find threatening -- a toucan and a gerbil.

[[folder:Tabletop Games]]
* The Kroot, an allied species of the Tau Empire in ''TabletopGame/{{Warhammer 40000}}'' use this as a means to evolve. By eating the flesh of another organism, a Kroot gains some of the traits its dinner had. For instance, a Kroot that consumes enough flying animals would eventually grow wings. Kroot chieftains, called Shapers, use their knowledge of Kroot genetics to pick out creatures with the most desirable traits for their kindred to eat, in order for their tribe to grow strong and conquer their foes. Their Tau allies see this as utterly barbaric, but value the Kroot's friendship over their habits.
** Technically it's the next generation of Kroot which gets the consumed abilities, in a hint of sanity in the flood of madness in 40k.
** The [[HordeofAlienLocusts Tyranid]] are also very good at this. Most of their enhancements are homegrown, but two Tyranid hiveships meeting is a very bad thing because they will fight to the death, then whichever one wins will take the most effective enhancements of the other and incorporate them into its soldiers. Also because of the Tyranid's ridiculously efficient digestive and reproductive processes, fleet will grow to the size of both of them put together.
** It's also mentioned in the 'Xenology' book that the Tyranid genome is basically a whole series of different gene sequences and types with different alleles and such all spliced together into an impossibly complex whole. The background image for the Tyranid gene sequence indeed reflects this, being made of... everything. (It's all still built from a standard genome template though, which is alluded to being the Tyranid Ripper).
* In ''TabletopGame/HunterTheVigil'', the Cheiron Group gives its employees supernatural powers by cutting out bits of monsters and stitching them into the subjects. This is given a {{handwave}} of the "Nobody has a clue how this works, it just does" variety. Not too surprising given that all the 'spare parts' come from creatures that are more-or-less explicitly ''magical''.
* The "Moreaus" (animal-human hybrids) in ''{{d20 Modern}}''. Also, the entire premise of the "Genetech" campaign setting (which extensively features the aforementioned hybrids in a battle against prejudice rather reminiscent of the X-Men films).
* ''TabletopGame/MagicTheGathering''
** The Slivers can apparently eat things, then assimilate the DNA into their own, and then [[LamarckWasRight their offspring have the traits of whatever they've ingested]]. And can then share those traits with any other Sliver within range.
** The ''Ravnica'' blocks feature the Green/Blue Simic guild, a group of genetic engineers who build creatures like [[MixAndMatchCritters Eel-hawks]] to survive on a DungeonPunk CityPlanet where the wilderness has all but vanished. Their signature mechanics involve manipulating +1/+1 counters, which represent bits and pieces of various plants/animals/[[BlobMonster oozes]].
* The Ancient Martians from ''TabletopGame/RocketAge'' managed to advance genetics to the point where they had a machine that could make all sorts of changes, like adding wings or claws to a person, although it did have its limits.

[[folder:Video Games]]
* Averted (and lampshaded in the quote on top of this page) in ''VideoGame/SidMeiersAlphaCentauri'', where University faction leader (and resident [[TheProfessor Professor]]) Prokhor Zakharov is quoted more than once on the subject of the limitations of genetics.
* ''VideoGame/BioShock'' has "plasmids", genetic upgrades that instantly give you fantastic abilities like telekinesis or the ability to shoot fire, lightning, or ice from your hands. {{Handwave}}d by advanced scientific research into creating stem cells, but even that doesn't begin to explain it. In RealLife a plasmid is a ring of DNA which can indeed be used to perform a very limited version of LEGO Genetics, but only to transfer a small number of genes into cells (and only in bacteria). The game also allows the PC to take an active plasmid out of his genome, which is a lot less plausible. The explanation for all these abilities (and the driving force behind most of the plot points) is Rapture's form of {{Unobtainium}}, ADAM. Its exact functions are unclear, but it makes the Little Sisters (who produce ADAM via a sea slug implanted in their guts...yeah) virtually invincible, as any wound they sustain is healed almost instantly by [[HealingFactor accelerated cell division.]] It is also what allows gene splicing by injection, and is apparently very addictive.
* ''VideoGame/ImpossibleCreatures'' is based pretty much entirely on this trope, and aptly named.
* Becomes a major plot point (with a twist) in ''VideoGame/WingCommander IV''. The {{Big Bad}}s have a pretty neat covert operation going--mass murders, being blamed on a Conveniently Available faction. Problem is, the murders (which are originally thought to be a plague), turn out not to be--[[spoiler:turns out the Big Bads have developed a nanotech weapon that kills people based on their genes--have the right gene set, you live, don't, and you die, in a genocide that would make Hitler green with envy. The parallelism is there and used--including the insane-general-that-thinks-humanity-is-weak-and-is-going-to-purge-it bit that Hitler used to rationalize his genocide. The results are shown in nauseating fashion--the weapon kills slowly, by dismantling the cells that have the incorrect gene sets--dissolving the person slowly and painfully.]]
* Used slightly believably in ''[[VideoGame/{{Crusader}} Crusader: No Remorse]]'', where a MadScientist explains to you that the "new generation" of [[SuperSoldier Silencers]] does not have the Silencer's "fatal flaw" (that being something vaguely approximating a conscience). Depending on how much understanding of genetics human science acquires this may not be entirely implausible.
* A much older game with a similar premise to Spore, ''VideoGame/EVOSearchForEden'', runs on this trope. Every time you add or remove a part, the change is done instantly. This can be exploitable in boss battles by changing one's neck from short to long or vice versa whenever you get low on health, completely refilling your health. The neck is the cheapest part to change, but you can substitute any part and do the same thing.
** A better tactic - and an even stranger example of this trope - was to grow a cheap horn, which would also refill your health. The horn would 'break' after attacking with it 3 times... and this would somehow count as an evolutionary change, which would refill your health ''again''.
** Admittedly, EVO isn't exactly clear on whether or not it's supposed to represent real evolution. There's substantial hints that the whole process is being hijacked by aliens, at least in the case of certain enemies, and many creatures berate you for not evolving "the proper way".
* ''{{Creatures}}'' is a rare aversion (at least partially). At least several "genes" go into the functioning of each organ, and let's not even get started on the ''brain''... The visible parts (head, limbs, etc.) can change in appearance with just one gene, but not be removed entirely or visibly duplicated (though the gene can be). (The "double tail" seen on certain C2 Norns, and the lack of tail on Ettins and some Norn breeds is a sprite thing.)
* ''{{VideoGame/Metroid}}'' did this to Samus, not once, but ''twice'': according to Samus' backstory, she was "infused" with Chozo DNA in order to allow her to survive on the planet Zebes, which is the reason for her superhuman strength, stamina, and agility. In the game ''Metroid: Fusion'', Samus is injected with the DNA of a Metroid, the only known natural enemy of the X parasite, following her infection. Not only does the vaccine completely destroy all traces of X in her system, this somehow alters her DNA so that she has the Metroid's ability to safely absorb X for health and upgrades, [[strike:alters the appearance of her suit (which is biologically linked to her)]], and gives her the Metroid's weakness to cold.
** The X parasites themselves steal the DNA from host creatures and then instantly assume their forms. They are even observed experimenting with their absorbed DNA: mixing and matching different strands to create hybrid creatures or mutants. They mostly stick to combinations that work, but we do see several attempts at the X attempting a combination only for it to [[BodyHorror fail horribly]].
* Nei and Rika of the ''VideoGame/PhantasyStar'' series. Nei is explained to be part biomonster and was created in a genetics lab. Rika was also created in a biology lab, but she was produced over the course of a thousand years' worth of research and testing to produce a stable and functional improvement on the Nei pattern, which was drastically flawed.
* Depending on whether they're viewed as an animal or a virus, this trope could be considered the very definition of ''VideoGame/StarCraft'''s Zerg; who swarm over alien races to absorb certain genetic traits from them, and at the start of the game, are trying to acquire beings with "psionic genes." The sequel shows more examples of such behaviour:
** In Wings of Liberty, the [[TheVirus Zerg hyperevolutionary Virus]] is shown infesting a scientist, inclusive a screen displaying that 99% of her DNA has been replaced by Zerg genes. She looks as good [[BodyHorror appropriately squicky]].
** With Heart of the Swarm, the pseudo-Biology gets taken to an entirely new level, with the genetic Chef Abathur sending you out to collect Essence from different species to aquire certain traits, from immunity to cold to being able to be split in two, with both halves surviving independently.
* This is probably what happens to VideoGame/{{Kirby}}, [[CannibalismSuperpower every time he inhales an enemy and absorbs his powers.]] His body often undergoes a complete and instant physical change, ranging from change of body color to obtaining [[NiceHat oddly shaped hats]]. But we're [[RuleOfCool completely okay with it]], since we don't know anything about the biology of Kirby's species anyway.
* ''VideoGame/MOTHER3'' has a multitude of battle encounters that are simply the unlikely combinations of two creatures, referred to as Chimeras. Such combinations include the [[http://walkthrough.starmen.net/mother3/image/enemies/cattlesnake.png Cattlesnake]], the [[http://walkthrough.starmen.net/mother3/image/enemies/batangutan.png Batangutan]] and the [[http://walkthrough.starmen.net/mother3/image/enemies/slitherhen.png Slitherhen]]. You even have to venture into the labs where these Chimeras are created.
* In ''VideoGame/{{Evolva}}'', your Genohunters are able to use their enemies' DNA to transform their body and acquire their attacks.
* ''VideoGame/StarControl'' 2 had this as a major plot point for some races. The Umgah can easily manipulate DNA with their vast scientific knowledge, and end up [[spoiler:accidentally reactivating the latent powers of one of the most deadly psychic creatures the universe has seen]]. The Mycon can supposedly do even better, altering their DNA and abilities by mere ''thought''.
* The ''[[Franchise/MetalGear Metal Gear Series]]'' involves a subplot in [[VideoGame/MetalGearSolid4 the fourth game]] that's causing the rapid aging of Snake: he was considered a high risk of being kidnapped and cloned again, so the biologists on the team simply tacked infertility on to his genes, as well as "terminator genes" to force rapid aging and an early death.
* In ''[[VideoGame/XCOMEnemyUnknown XCOM: Enemy Within]]'', this is made possible by the ImportedAlienPhlebotinum, Meld. There are 10 different genetic alterations that can be applied to your troops, 9 of which are unlocked by autopsying fallen aliens: ranging from being able to jump builds to having a (smaller) secondary heart or being able to camouflage in the right circumstances.
** The Exalt troops have also been genetically modified but all have been disfigured to look like snake men for their efforts, with only the elite troops showing any serious changes. It is speculated that this is because they lack proper access to Meld and are too heavy handed with the efforts, whereas your soldiers all look perfectly normal.

* Spoofed in [[http://www.angryflower.com/breakf.gif this]] WebComic/BobTheAngryFlower comic.
* ''Webcomic/ElGoonishShive'' has Uryuom eggs, which somehow combine the DNA of all of the parents and create a composite being with all of their traits. If more than one species is involved, it generally also gains the ability to [[VoluntaryShapeshifting change shape]]. Those must be some pretty advanced eggs.
** Later {{justified|Trope}} as it being a type of magic (well, sort of; it's complicated and hasn't been fully explained yet) inherent in the species.
* The substance Professor T.X. injects into the M9 Girls modifies their genetic structure overnight, so that they are able to absorb cosmic energy into their bodies, which gives them their powers, as told in the eponymous ''Webcomic/M9Girls''.
* Played to the hilt by ''Webcomic/{{Narbonic}}.'' Not only will an infusion of a computer geek's DNA turn you into a computer geek, it'll even give you his cigarette habit, and magically reappearing cigarettes!
* The "genetic chimera thingie" Molly, her {{clon|ingBlues}}e Galatea, and the {{Mutant|s}} {{Kaiju}} Unigar the Vast Unicorn in ''Webcomic/TheInexplicableAdventuresOfBob.''
* The device that altered ''Webcomic/{{Spinnerette}}'' worked basically this way, as well.
* In ''Webcomic/SluggyFreelance'', Santa Claus believed that genetics could be the toy craze of the future, with kids playing with DNA like it was Lego bricks. As part of his research initiative, one of his elf scientists designed Rockem' Sockem' Robot gas, which makes two strands of DNA bash together and battle each other for survival. Considering that the actual Santa Claus is involved, you can guess that Sluggy Freelance doesn't take genetics too seriously.
* In ''Webcomic/TheDragonDoctors'', Mori points out that DNA can't be treated like a bunch of building blocks ordinarily, but the use of ''magic'' allows one to treat traits as conceptual objects that may be swapped out at will.
* In ''Webcomic/TheGreeningWars'' "The Greening" is an organization that basically has this a policy
* The protagonist in ''Webcomic/{{Wildlife}}'' is a CosmicHorror that does this. She can absorb biomass from (almost) any living thing and use it to create or modify her own creatures in any way she desires.
* The Chio from ''Webcomic/{{Messenger}}'' and ''Webcomic/{{Follower}}'' were created this way.

[[folder: Web Original]]
* ''Literature/AGreyWorld'' Manages to achieve this with plausible, yet awesome, outcomes. [[spoiler: Alexis is implied to be the child of a MadScientist's ForScience experiments. But reasonable genetic material sources and sensible results give it a realistic feeling.]]
* ''OrionsArm'', for all its much vaunted scientific accuracy, still features this trope in the form of splices (animals augmented with human DNA) and rianths (humans who added animal genes to themselves).
* [[Wiki/SCPFoundation SCP]]-[[http://www.scp-wiki.net/scp-040 040]] has this ability. The creatures she creates are designated SCP-040-1 and essentially act as her [[PetMonstrosity pets]].
* The NewsParody ''[[Blog/ElChiguireBipolar Chigüire Bipolar]]'' has the entry [[http://www.elchiguirebipolar.net/22-10-2013/descubren-que-el-gen-de-la-viveza-criolla-en-realidad-es-el-gen-de-ser-un-mamaguevo/ Scientists discover that "creolean slyness" gene is in reality the "being a cocksucker" gene]], in which various cultural traits are given genetic status.
* In ''Literature/{{Twig}}'', DNA is referred to as "the living code," and was unlocked by Mary Wollstonecraft Shelley in the early nineteenth century, creating a codex of procedures which are used for biological engineering.

[[folder:Western Animation]]
* ''WesternAnimation/BatmanBeyond'' features a gang called the Splicers who have had their DNA spliced with different animal DNA turning them into PettingZooPeople. Terry is turned into a literal Bat-Man (ala the Man-Bat) at one point, but it is easily reversible. Splicing is made illegal, but at first was perfectly legal and akin to body piercing and tattooing.
** And, of course, Man-Bat is also an example. He was trying to isolate the bat's sonar-genes in order to cure deafness.
** Maybe in the comics. On the Batman series, his father-in-law was into the whole 'bats will survive the next cataclysm' deal. Apparently Langstrom tested the human-to-bat formula on ''himself''.
** A Subversion [[spoiler: Amanda Waller wanted to ensure there would always be a Batman and had Warren McGinnis' reproductive DNA replaced with Bruce Wayne's. Warren did not turn into a Bruce Wayne lookalike. Also, while events still led Terry to become Batman, he's a very different one from Bruce Wayne as he also has inherited traits from his mother.]]
* ''WesternAnimation/KimPossible'':
** The [[{{Supervillain}} villain]] [=DNAmy=]'s specialty: She combines living creatures to make MixAndMatchCritters.
** Drakken's customized clones.
* ''WesternAnimation/{{Teenage Mutant Ninja Turtles|1987}}'' had a character called Bugman, whose origin had him accidentally combine his genes with those of various arthropods. For some reason, his acquired traits are only expressed when he gets angry.
* The DarkerAndEdgier second season of ''WesternAnimation/LegionOfSuperHeroes'' features a clone of Superman provisionally called Superman X, who had ''Kryptonite planted in his genes!'' Instead of making his embryo self nonviable due to both Kryptonite and the loss of whatever the Legos that got visibly ''removed'' to make room for green K, Supes X has scary-looking eyes, immunity to Kryptonite, and shoots blasts of green ice in addition to the usual Kryptonian power set. (His extra powers, and entire existence, came from a bit of ExecutiveMeddling about "beefing up" Superman.)
* ''WesternAnimation/DannyPhantom'', full stop. He got ghost powers implanted into his DNA!
* An episode of ''WesternAnimation/TotallySpies'' involved a scientist who used a... laser-gun-machine-thingy to "inject human DNA" into animals, making them walk upright and consume human food and think and speak perfect English and ''oh my god''.
** And in another episode, a fashion designer uses a serum of some sort to give humans animal features, so she can ''[[{{Squick}} make seamless coats out of them]]''. Of course, it is perfectly reversible.
** Yes. You just can't apply [[FridgeLogic logic]] to [[FetishFuel that kind of show.]]
* The ''WesternAnimation/SushiPack'' episode "Fish Tales," Oleander teams up with a scientist who specializes in "DNA stuff that can alter human beings." By combining his DNA stuff with her "special" seafood bisque (and Kani's recently shed shell), Oleander is instantly endowed with a crab shell on her back, and her hands turn into pincers. The effect only [[HourOfPower lasts for two hours]], though.
* In ''WesternAnimation/StreetSharks'', [[BigBad Dr. Paradigm]] literally stacks segments of DNA onto each other like Lego. He explains: "A little bit of this, a little bit of that, add some splicing agent, radiation and done."
* In the 1980's ''WesternAnimation/TheNewAdventuresOfJonnyQuest'' episode "Peril of the Reptilian," not only does Dr. Phorbus create his lizardman by combining human DNA with DNA from ''dinosaur bones'' he also has an entire island full of mix-n-matched dinosaurs such as a tyrannosaurus with pterodactyl wings, and a pterodactyl with a brontosaurus head and neck. (Since Phorbus touts the lizardman as his ultimate creation, these latter creatures seem to [[ForScience serve no purpose]].)
* In ''TheWhywhyFamily'' episode about genetics, Micro and Scopo shrink down and go inside Zygo to show Victor how DNA works. Victor physically moves Zygo's genes around like building blocks, causing him to turn into a multitude of other animals.
* Played with in "{{WesternAnimation/Family|Guy}} Gay" when Peter is injected with the squirrel gene and gay gene. He also gains the Seth Rogen gene which gives him the appearance of being funny even though he hasn't done anything funny.
** In an episode where all government is disbanded in Quahog, [[ExtremeOmnisexual Quagmire marries a giraffe]]. The next scene shows it giving birth to a baby giraffe with ''Quagmire's face''. The baby's first word is "[[{{Catchphrase}} Giraff-ity]]" and yet Quagmire still insists, "Yeah, [[BlatantLies that's not mine]]."
* ''WesternAnimation/SpiderManTheAnimatedSeries'': In this universe, there are in many scientists who specialize in it; it's called "Neogenics." Most of the RoguesGallery were created by neogenics either GoneHorriblyWrong or GoneHorriblyRight. Despite this, most characters' comic book origins are maintained. Connors trying to regrow his arm, Stillwell creating the Scorpion for Jameson, and of course a certain UnluckyEverydude who was bitten by a spider that had passed through the ray (a "neogenic recombinator" uses radiation rather than [[ILoveNuclearPower radiation just being magical]]) all happened by way of this new science that's all the rage in this universe. However, it was ''Peter's'' neogenics experiment (trying to cure himself during the six-arms saga) that Michael ComicBook/{{Morbius}} borrowed. A bat got into it, Michael got bitten, and [[OurVampiresAreDifferent you know the rest]].
* This is basically everything Dr. Sevarius does in ''WesternAnimation/{{Gargoyles}}''. He even made his own Gargoyles by using bat DNA for wings, big cat DNA for sharp claws and teeth, & electric eel DNA to power the wing muscles, which also has the side-effect of allowing them to shoot electricity blasts. All he needs after that is [[spoiler: a live human to serve as a base.]] As if you didn't already see that coming.
* D.A.V.E. from ''WesternAnimation/TheBatman'' is this with the brainwaves of Batman's RoguesGallery like Joker's acrobatic feats and Penguin's mastery of martial arts. He also has the brainwaves of Hugo Strange and Riddler, making him intelligent.
* Jenny and Zap from ''WesternAnimation/DexHamiltonAlienEntomologist'' are both the product of genetic engineering which grants them special abilities Including fly wings in Zap's case).
* In the year 2772, a meteor strikes Acmetropolis, releasing bizarre radiation that gives the ''WesternAnimation/LoonaticsUnleashed'' their superpowers. Not to be outdone, The Ringmaster and Otto the Odd bombard the Loonatics with their "sonic DNA scrambler," which mutates them in seconds into MixAndMatchCritters with superpowers.
* PlayedForLaughs in ''WesternAnimation/RickAndMorty'' episode "Rick Potion #9". Creating a love potion from vole genes, Rick soon attempts to undo the damage it causes by making an antidote with praying mantis DNA; since voles pair for life and mantises eat their partner, he concludes [[InsaneTrollLogic that they're genetic opposites.]]
-->'''Rick''': Yeah, I don't know what I was thinking. "Mantises are the opposite of voles"? [[LampshadeHanging Obviously DNA's a little more complicated than that.]]
* The Season 25 episode ''The Man Who Grew Too Much'' of ''TheSimpsons'' had Sideshow Bob playing around with this trope. At first he's just shown making [=GMOs=] (using a blender to mix a potato and tomato into a liquid that can move under its own power). But then he reveals he's been giving himself genetic modifications including: an ant's strength, grasshopper-thighs, sonar of a killer whale, and "oh right, I gave myself gills".

[[folder:Real Life]]
* In recent years, genetic engineering has become incredibly simple and there are large libraries of open source genes which one can order to splice into the genetic code of a sample. The best known term for this technology is [[BrandNameTakeover BioBricks]].
* As revealed in the February 2012 coverstory of National Geographic Magazine, the distinctive traits of domestic dog breeds work like this.
** A small mutation with a large effect is unlikely to benefit the animal in the wild, but humans tend to take such surprises and breed them. Thus, such changes have become the building blocks of dog breeding, allowing humans to radically alter ''Canis lupus'' at a relatively rapid speed.
** Therefore, an odd physical trait in a domestic dog tends to result from one mutation with a large effect, rather than the accumulation of many genes with small effects seen in the wild.
** This is made all the more remarkable when we remember that the genetic engineering techniques used here were of the oldest variety known to humanity.
* Modifications that work on the chemical level ''do'' have Lego characteristics (this is what Provost Zakharov is talking about). Most prominent would be the coding of fluorescent proteins derived from jellyfish, inserted into the DNA of various animals as advanced as mammals and actually working--the mice in question do produce the chemical, which can then be tracked down for interesting insights. There are also bio-engineered crops, "injected" with traits that strengthen crops (e.g. protection against the cold, built-in anti-parasite genes, et cetera) taken from fish and bees. It sent hippies into a fury. Note that this is always done to fertilized eggs; there currently is no way to specifically alter the DNA in every cell in a fully grown animal (or a still growing animal). Of course, once you have said animal, breeding becomes an option, although the viability of that with either modified or non-modified animals varies considerably.
** [[http://news.cnet.com/8301-10784_3-9833107-7.html Glow In The Dark Cats]], anyone?
*** However, note also that this is a logistical problem, not a genetics or physics issue. There's nothing physically impossible about taking an adult organism, and going through every one of its cells one by one, making the same change in them all. We "just" don't have the technology to do so while not killing them, not missing any, and doing it all fast enough to outrun and overtake the continual introduction of new cells. Of course, even if you did manage to do so, there's no telling what would result from applying the "new" chemistry to the "old" existing structures, the end result may still be very different from having made that same genetic change at the single-cell stage, or even a few years, days, or even hours earlier or later in the creature's life cycle.
*** However, it could possibly be done with a virus, as they work by altering DNA. Of course, it's still difficult to get it right, but this is being considered as a way to treat genetic illnesses
* This is also only applicable in a very, very limited fashion. Producing glow-cats means just one or two extra molecules manufactured by the body, but making them grow scales or tentacles would be something completely different.
** It's more of a question of fully understanding all the interactions between genes. There are no "tentacle" genes, but the growing of tentacles is coded as a complex interaction of genes. Most likely the entire skin and ossature, as well as some fundamental structural changes, would have to be made. Those changes would however be so fundamental the cat would really no longer a be a cat in any way we define the term "cat".
** The sequence for [=GFP=] (green fluorescent protein) tends to work because it provides instructions to generate a protein that glows when stimulated, rather than a piece of the instructions for forming specialized "glow tissue/gland/organ cells" which most splicing subjects would likely be unable to use. Generally speaking, any cell with genetic material is capable of generating a protein so long as it has sufficient molecular material to build it; it just won't always know what to do with that protein. Cells don't need to do anything with [=GFP=]; it just sorta' sits there and glows. Because of this, the sequence for [=GFP=] is basically "compatible" with almost every type of cell, allowing scientists to [[strike:[[MadScientist make things glow when they get bored]]]] highlight cells that they want to observe in studies and experiments.
* Goats can be genetically modified to produce spider silk (in an example of RealityIsUnrealistic, someone actually gave an episode of ''Series/{{CSINY}}'' that showed this an entry on this page, claiming it was a particularly bad example of unrealistic science). How that actually works - the genetic alteration causes female goats to produce the protein spider silk is made of in their milk. To get spider silk from that, the protein has to be separated from the milk (which is a process), and then somehow pushed through a ridiculously small aperture to make the molecules snap into place. The silk made through this process still isn't as thin or as strong as natural spider silk. [[http://en.wikipedia.org/wiki/Spider_silk#Artificial_spider_silk See the other wiki.]] [[WesternAnimation/TheSimpsons Spidergoat, Spidergoat...]]
* There's also the ''hox'' genes, discovered so far in a number of creatures (particularly fruit flies) which appear to control the physical structure of the body. Messing with them can produce major changes in the body of the target, such as the aforementioned eyeless (or legless, or legs-instead-of-eyes...) fruit flies, but is also often fatal. This is subject to the usual proviso of not affecting developed organisms.
** Hox genes, short for [[http://en.wikipedia.org/wiki/Homeobox "Homeobox" genes]], are in fact named as such because they are highly conserved, being found in everything from plants to fungi to fruit flies to '''vertebrates'''. Think about '''that''' for a minute or two. [[spoiler: Yes, that means you have them too.]]
** Not only that, these genes are expressed in different parts of the body, some in the head, others in the thorax, others in the abdomen, etc, and the order in which they are expressed from head to tail correlates exactly with the order in which they are written on the chromosome. This suggests that we could reorder the genes to reorder the body.
*** This also depends on studies from the fields of epigenetics and developmental biology. As the same gene may be expressed differently in different parts of the body based on how they are transcribed and what the protein produced from translation does.
*** There is also this interesting note: If you splice some genes known to generally control the development of human eyes into a fruit fly genome at a point on the Hox gene controlling development of the abdomen, an eye will grow on the fly's abdomen--but it will be a perfectly ordinary fruit fly eye (well, ordinary except for the fact that it's on the abdomen).
*** It is also possible to swap the gene that controls the formation of eyes from, for instance, a mouse into a fruit fly and have it control the production of normal fruit fly eyes (even in the normal place, if you insert it in the correct location). Mice are deuterostomes while fruit flies are protostomes (this has to do with very basic details of how the embryo forms the gut of the organism, and is one of the oldest divisions in animals), which means that hox genes from the most distantly related branches of the animal kingdom are so intensively conserved that they remain interchangeable.
* Genetically modified foods. The few successful ones so far have generally involved adding DNA, usually bacterial, that causes a plant to produce a protein that it normally doesn't. For example, corn that produces bT toxin, effectively making its own pesticide. They also managed to make soybeans resistant to pesticides. These receive testing that compares toxins, nutrients, and allergens of the modified crop to the normal one.
* Every year, hundreds of teams of university students participate in the International Genetically Engineered Machine (iGEM) competition, which is built on the premise that life can be broken down into a series of off-the-shelf, interchangeable parts and reassembled into creatures that have never existed. These parts are called "[=BioBricks=]." The competition's grand prize? A solid-silver Lego brick. It's a way to introduce a new field of science called synthetic biology.
-->"...Two things set synthetic biology apart [from genetic engineering]: The DNA building blocks don't have to come from nature; they can be designed and created in a lab, a process that's becoming faster and cheaper. And there's the idea that life, like cars or computers, can be designed and built from standardized parts that behave predictably." [[http://www.washingtonpost.com/wp-dyn/content/article/2009/10/22/AR2009102204628.html?hpid=artslot]]
** Completely synthetic DNA has now been made, it just needs to be injected in a microbe to kick-start it. It's more complicated than that of course, but it's ''awesome''.
* Grad students modified E. coli to [[http://www.innovations-report.com/html/reports/life_sciences/report-74702.html smell like mint.]]
* Bacteria, being basically protein-producing sacks of cytoplasm, don't have to deal with the complexities of large-scale structures in their bodies. Not only can they be artificially injected with entirely foreign DNA to produce new proteins and behave in new ways (like producing human insulin or eating oil slicks), but they regularly drop bits of their own DNA and pick up bits that were left behind by other bacteria as part of their natural life cycle. That includes bits dropped by other species - in fact, the typical definition of "species" doesn't really apply to bacteria at all, since they all have the ability to take bits and pieces of each other, the entire bacterial ecosystem is more of a loosely-bound genetic "marketplace" with LegoGenetics pieces up for grabs.
** This "horizontal gene transfer" ability can cause significant problems in the battle of humans against dangerous bacteria - for instance, if you use too many antibiotic medicines when you don't need them, you could put pressure on the harmless, symbiotic bacteria living in your body to become immune to them. Not too much of a problem on its own - but if a dangerous bacterium ends up in there later, the dangerous bacterial strain will sometimes grab the "immunity gene" from the harmless bacteria already living in your body and become a drug-resistant pathogen from the start.