''Killer Instinct'' can refer to:
* [[VideoGame/KillerInstinct A series of 90s fighting games]]
** [[VideoGame/KillerInstinct2013 The 2013 reboot of said fighting games]]
* [[Series/KillerInstinct A 2005 crime drama]]
* The first part of the 2008 ''Film/{{Mesrine}}'' film duology.
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