[[quoteright:350:[[Film/ResidentEvilApocalypse http://static.tvtropes.org/pmwiki/pub/images/Apocalypse_2191.jpg]]]]
[[caption-width-right:350:[[SaltTheEarth Cleanse.]]]]

->'''Pi:''' There are so many possibilities... I'd have to requisition some ordnance, sir.\\
'''Tagon:''' You are ''not'' allowed to ''nuke Northport'' "just to be sure."\\
'''Pi:''' I'd have to nuke a lot more than just Northport to be ''really'' sure.
-->--''Webcomic/SchlockMercenary'', on defending Northport

%% One quote is sufficient. Please place additional entries on the quotes tab.

TheVirus, ThePlague, or some similar infestation or contaminant has gotten out of containment and threatens to spread uncontrollably. If any conventional means have been deployed to control it, they were grossly inadequate. [[GodzillaThreshold The danger is now severe enough]] that Plan B - maybe even Plan A - is sheer [[TheresNoKillLikeOverkill Overkill]]: a local armageddon which will destroy the facility, city, or entire region in one blast. It could be [[NukeEm a nuke]], it could be a [[KillItWithFire thermobaric explosive]], it could be OrbitalBombardment - but whatever it is, high civilian or friendly casualties are almost certain, and are chalked off as "acceptable losses".

Possibly justified in that if the situation is bad enough to warrant this level of action, anyone within the affected radius not heavily coated in PlotArmor is likely either dead or soon to die anyway, and if the plan works it can at least result in a PyrrhicVictory. Often a ShootTheDog moment, sometimes followed by a WhatTheHellHero moment. Rarely it can be a HellYeah moment if collateral damage isn't an issue [[note]]or is left to be FridgeHorror[[/note]] and it [[NoOneCouldSurviveThat at least seems to work]]

Sometimes this strategy works, [[FailsafeFailure sometimes it doesn't]], and sometimes it ''[[NiceJobBreakingItHero really]]'' [[OhCrap doesn't]] [[InfernalRetaliation work]]. See FeedItABomb for similar philosophy of pest-control on a smaller scale, HurlItIntoTheSun when you bring the ''target'' to the cleansing fires instead of the other way around, and FieryCoverup for when the bombardment is intended to cover up the evidence as much or more than it is to destroy the threat.

SelfDestructAsFailsafe is a special case of this in which the decision to use a nuclear weapon ''before'' the crisis exists.
----
!!Examples:

[[foldercontrol]]

[[folder:Anime and Manga]]
* ''Anime/BloodPlus'': The American government's primary method of dealing with [[OurVampiresAreDifferent chiropteran]] outbreaks is "Option D," in which the area in question is bombed until there's nothing left but a smoking crater.
* In ''Anime/NeonGenesisEvangelion'', the "nuke it to be sure" strategy is part of the standard response to an Angel attack. It never works. First the conventional forces attack, then they use something called an "N2 mine" which is described as the next step beyond thermonuclear explosives. When those fail, ''then'' they send out the Evas. This serves to send several frightening messages. First, that the Angels are so threatening that weapons beyond nuclear are a standard response; second, that they are so powerful that such weapons have no effect; and most subtle and chilling, that the Evas are so dangerous that the military is willing to try nukes ''before'' sending them out. This order of attack is the viewer's first clue just how scary Evas really are. It only gets worse from there.
[[/folder]]

[[folder:Comics]]
* In ElEternauta some world power(s) has(ve) been sending [[NuclearOption ICBMs]] towards the center of the [[AlienInvasion invasion]], luckily for our heroes the bad guys have machinery that renders the nukes void. [[spoiler: Even after the heroes disable said machinery and the city is leveled, it doesn't help a bit because [[TheCavalry reinforcements shortly arrive]] and in the end [[HopelessWar we learn the Earth was promptly defeated]].]]
* In MarvelZombies, a nuclear strike was considered to contain the superhero zombie infection. Then Quicksilver caught it, and "containment" was no longer an option.
* In Jim Starlin's ''The Metamorphosis Odyssey'' (first appearance of Dreadstar ), the alien villains Zygoteans are bent on conquering the Milky Way; once they are done, they'll go to the next galaxy. ByronicHero Aknaton understands he cannot save the Milky Way from this horrible fate. His plan is to obliterate the Milky Way before the Zygoteans are done with it, so he can at least save other galaxies. As Akenaton is very long-lived, he thinks in a very long term.
* During Secret Wars II, Phoenix (Rachel Summers) from ComicBook/{{X-Men}} considered destroying the whole universe in an attempt to stop the Beyonder: He was too powerful to be affected by any "common" attack, but Ray theorized he may (only may) be unable to survive if the universe around him ceased existing. At that point in the plot the Beyonder, while clearly a PersonOfMassDestruction , was only arguably a villain - Who's the OmnicidalManiac now, Ray?
** She decided to do this after the Beyonder had seemingly caused the NewMutants to be [[RetGone erased from existence]], with only Kitty Pryde (due to her magical connection to one of their members) even remembering that they ever existed. But Rachel had also become somewhat obsessed with eliminating the Beyonder, and he went out of his way to provoke her to keep trying. When she backs down without destroying the universe, he says that he would've survived it anyway. And expresses disappointment that she didn't go through with it.
*** Her first attempt to kill the Beyonder involved [[http://img201.imageshack.us/img201/3976/phoenixnukeii5.jpg something resembling an actual nuclear attack]]. It caused absolutely no damage either to him or the surroundings. [[TheOmnipotent Because he wouldn't let it cause any damage]].

[[/folder]]

[[folder:Film]]
* ''Franchise/{{Alien}}'':
** ''Film/{{Aliens}}' is the TropeNamer: this method is suggested for dealing with the alien infestation of Acheron, but is never executed for reasons beyond the Marines' control. The [[spoiler: first climax of the film]] renders the point somewhat moot.
** This was also intended in the first film. The Nostromo was self destructed by the crew in an attempt to ensure the alien would be destroyed along with it. Things didn't turn out that way.
** In ''Film/AlienVsPredator'', one Predator detonates an explosive device in the alien hive, destroying the entire pyramid. Flashbacks reveal that this is pretty much their standard way of dealing with alien infestations.
** In ''AliensVsPredatorRequiem'', the U.S. Army drops a nuclear bomb on the town of Gunnison, CO, to contain an infestation of Xenomorphs.
* In ''Film/ResidentEvilApocalypse'', the Umbrella Corporation fires a nuclear missile at Raccoon City to cover up an outbreak of the T-Virus, which is also what happened at the end of the third game of the series, though they've been [[NuclearWeaponsTaboo rather vague]] about whether it was actually a nuke or not. They manage to cover up the outbreak, but as revealed in ''Film/ResidentEvilExtinction'', the virus survives and causes TheEndOfTheWorldAsWeKnowIt.
* In ''TheCrazies 2010'' remake, the U.S. Army incinerates a small Iowa town to contain a leaked biological weapon.
** In the original 1973 version of ''TheCrazies'', a nuclear strike was discussed, but not used.
* In ''[[Film/TwentyEightDaysLater 28 Weeks Later]]'', the Rage virus escapes containment. The US Army panics and napalms most of the Isle of Dogs. It doesn't help.
* In ''Film/ReturnOfTheLivingDead'', the Army nukes Louisville, KY, to destroy a horde of zombies created by the chemical agent 2,4,5-Trioxin. This actually spreads the gas further.
* In ''Film/{{Outbreak}}'', a fuel-air bomb was used in the beginning to purge an isolated outbreak of the Motaba virus. Later, an American town was saved from a similar fate when a cure was devised from the original host.
* The option was suggested in ''Film/DawnOfTheDead'' (1978) by the eyepatch-wearing Dr. Rausch in a television interview. He was not taken seriously.
* In ''Film/TheAndromedaStrain'', this trope was averted when the protagonists realized a nuke would actually spread the contagion much, much further.
* The goofball Thai film ''SARS Wars: Bangkok Zombie Crisis'' shows the Thai government destroying an apartment complex to halt the spread of a strain of SARS virus which turns people into zombies.
* In ''Film/{{Cloverfield}}'', the exact nature of the [[NukeEm Hammerdown Protocol]] is never explained, but it clearly involves a WeaponOfMassDestruction or maybe several. The fact that the US Army was willing to do this on [[BigApplesauce Manhattan Island]] is meant to indicate how desperate the situation had become.
* In ''Film/TheAvengers'', the World Security Council decides to simply [[NukeEm nuke Manhattan]] to contain the invading Chitauri forces, despite the fact that the Avengers are still continuing their efforts to stop the Chitauri and that there's still civilians evacuating the area. SHIELD Director Nick Fury declares the idea a "stupid-ass" strategy for dealing with the invasion, and takes down the nuke carrying plane with a rocket launcher. [[spoiler: It's a pity that someone on the WSC was GenreSavvy enough to launch a second plane.]]
* In ''{{Pontypool}}'', the Canadian government eventually bombs the hell out of the titular city.
* The first few {{Kaiju}} in ''[[Film/PacificRim Pacific Rim]]'' had to be brought down by [[NuclearOption nuclear weapons]], as all other attempts to destroy the creatures simply had no effect at all. However, the sheer level of collateral damage that ensued made this an increasingly non-viable option, leading to the development of the [[GiantMecha Jaegers]].
[[/folder]]

[[folder:Literature]]
* Probably one of the oldest instances of this trope, the epilogue paragraphs of HPLovecraft's "The Lurking Fear" have the main character hiring a team to dynamite the mansion the story centers on, a significant portion of the surrounding forest, and any caves or tunnels they can find- apparently this was. He still worries that it won't be enough.
* ''Literature/TheDresdenFiles'' has one of the only effective ways a human can take down a certain EldritchAbomination is to strand it in a nuclear test.
* In ''DayByDayArmageddon'', by J.L. Bourne, the government nukes several large cities to contain a zombie plague. This only leads to [[NiceJobBreakingItHero fast, twitchy, radioactive zombies]].
* In ''{{Contagious}}'', by Scott Sigler, Detroit is nuked to contain the spread of an airborne plague which puts people under the mental control of a little girl.
* In ''Literature/JurassicPark'', the Costa Rican government bombs Isla Nublar, but this didn't make it into the film.
* Used [[ShoutOut word-for-word]] by Literature/CiaphasCain, when describing [[EarthShatteringKaboom the correct way to deal with]] [[spoiler:a Necron tomb under a refinery]]. Unfortunately for Cain, the [[HyperspaceIsAScaryPlace nature of FTL travel in the Warp]] means the Navy is ''too slow'', so he has to resort to a giant bomb augmented by several hundred thousand gallons of raw promethium.
** Also used word-for-word by Lord General Zyvan regarding orbital bombardment of Tyranid swarms and their so-to-speak bases.
* The [[Literature/AgentPendergast Douglas Preston/Lincoln Child]] novel ''Literature/MountDragon'' employs this trope twice.
** It is first described that the Soviets carpet-bombed a biological research facility and the neighboring village to stop an outbreak of a genetically modified organism in the 80s.
** Later, [[spoiler:the underground laboratory at the Mount Dragon complex itself is pumped full of superheated air from the sterilizing units on the surface, turning the whole facility into a canned inferno.]]
* Averted in ''WorldWarZ'': nuclear weapons are never used against zombies; however, [[spoiler: Pakistan and Iran engage in a brief nuclear war against one another, and the Chinese politburo are annihilated by a nuke from a rogue Chinese submarine.]]
** In a non-nuclear example, the city of Yonkers is flattened by thermobaric weapons when a poorly-planned infantry engagement goes awry. They do take out tens of thousands of zombies, but that's not much when there's a million more behind them, and their effects on respiratory systems are nullified, greatly reducing their effective radius.
* In ''Literature/{{Animorphs}}'', [[spoiler:the Andalite military attempts to do this to the ''entire Earth''. Ax manages to force them to stop, though.]]
** It's worse than that. [[spoiler: Their plan isn't just to sterilize Earth to kill the Yeerks on it - their plan is to sabotage Earth's (thus far fairly damaging) resistance, lure ''more'' Yeerks in to infest the populace, and ''then'' sterilize it. It all comes crashing down when Ax contacts the Andalite military command and civilian media simultaneously, without telling either party, and [[EngineeredPublicConfession gets the military to discuss the plan]]]].
* In ''Patient Zero'' by Jonathan Maberry, a secret bunker uses its geothermal power supply as an emergency self-destruct mechanism.
* In the Jonathan Maberry novel ''The King of Plagues'', terrorists plotted to release a genetically engineered, airborne strain of Ebola from the Scotland-based laboratory which developed it. [[spoiler:The nuclear option would have been employed had the protagonist failed to save the day.]]
* In a different Jonathan Maberry novel, the government intends to firebomb the town of Stebbins, Pennsylvania, to contain (and cover up) a zombie outbreak. [[spoiler: they change their minds when footage of the outbreak ends up on [=YouTube=].]]
* A small-scale example in ''[[XWingSeries Wraith Squadron]]'': on Storinal, the Wraiths break into a disease-control center that houses small samples of various contagions for lab use. Their security includes a plasma bomb array, capable of leveling several city blocks, in case of leaks. Fortunately, Kell Tainer is able to defuse it (then hooks it back up before they leave, so that no one realizes they were there).
* In NightOfTheLivingTrekkies, the government decides on nuking the greater Houston metropolitan area as the best option for taking out the zombie plague that's broken out all over the city.
* Non-plague example: In Creator/JohnChristopher's ''The Death of Grass'' (US title: ''No Blade of Grass'') the British government decides to nuke cities to minimize the number of starving refugees that would otherwise roam across the countryside. (Though everything falls apart before they can actually execute the plan.)
[[/folder]]

[[folder: Live Action TV ]]

* An episode of ''Series/TheChampions'' involved an island where evil scientists were making a lethal gas for chemical warfare or terrorist attacks. At the end of the episode, the Army has a nuke dropped on it.
* In the adaptation of ''Series/TheWalkingDead'', the CDC is rigged with a thermobaric device to prevent the release of [[LargeHam WEAPONIZED SMALLPOX!!]]
** Later on, in the second season, we are treated to a flashback of military helicopters trying to contain the zombie outbreak by [[KillItWithFire dropping napalm in the streets of Atlanta.]] Judging by the fact that [[YouCantThwartStageOne the rest of the series exists]], [[CaptainObvious it probably didn't work.]]
* The {{Doctor Who}} episode ''Nightmare in Silver'' had a scene when it's mentioned that previously [[spoiler: the Cybermen were only defeated by blowing up an entire galaxy resulting the death of trillions.]] In the story itself the standard procedure upon encountering any survivors is to implode the entire planet immediately, before any damage is done.
* Applied very, very stupidly by the Borg Queen in ''Series/StarTrekVoyager'', in the episode "Unimatrix Zero". Let's lay out the issues: only a handful of Borg went rogue, something like 1-5 drones per cube - a construction that contains hundreds or thousands of drones, with many cubes having no rogue units at all. And the effect that releases them from the Collective is not contagious. For some reason, the Queen decided that the optimum way to handle this was to explode entire cubes to deal with these rogues. (Website/SFDebris concluded that this was a side effect to [[AssimilationBackfire assimilating Janeway]].)
[[/folder]]

[[folder: Tabletop Games]]
* Occurs with depressing regularity in ''TabletopGame/{{Warhammer 40000}}'', usually from the Imperial method of Exterminatus, either by Virus Bomb or Cyclonic Torpedo or good ol' fashioned "shoot the planet until it breaks apart" trick. Ironically, it's also always justified. (Would you rather a quick, relatively painless death or millenia of torment as your soul is flayed from you along with your skin inch by inch?)
** For instance, one of the major reasons for Exterminatus is the fear of a planet imminently becoming a Daemon World (it can't be used on one that's ''already'' a Daemon World since they don't completely exist in normal reality any more). Or the discovery of a Necron presence on the world - although unless the Imperials are very lucky, they probably won't discover the tomb until the Necrons awaken and kill everything. Or perhaps its invasion by [[BugWar Tyranids]], [[AxCrazy Orks]], or [[FateWorseThanDeath Chaos cultists]] - there are ''many'' worse things in 40k than a quick death by lance cannon.
** ''Almost'' always justified. 40k being the [[CrapsackWorld setting]] it is, there have been occasions where Exterminatus orders have been issued (and carried out) for reasons as petty as a communications specialist not being allowed to retire and return home. Poor, poor Stalinvast...
** And of course, as per usual with 40K, sometimes TheOnlyWayToBeSure ''isn't'' 100% sure. The Imperium has stopped using Virus Bombs once they discovered that making an entire planet's population with viruses was strengthening Nurgle, the Chaos god of disease. As Literature/CiaphasCain ('''HERO OF THE IMPERIUM!''') once put it, sometimes Exterminatus just gives them ideas.
* A common policy among the more hardline Firewall members in ''EclipsePhase'' is "sometimes, blasting the habitat into radioactive dust is the only way to...well, you know". Sometimes it works wonders; when applied by Earth's power blocs against the [=TITANs=], during the Fall, it was about as effective as a rubber hammer.
[[/folder]]

[[folder: Video Games ]]
* Quite a few ''Franchise/ResidentEvil'' games end with this:
** [[VideoGame/ResidentEvil The original]] had the mansion explode in a self-destruct sequence.
** ''VideoGame/ResidentEvil2'' and ''[[VideoGame/ResidentEvil3Nemesis 3]]'' had the government destroy Raccoon City with nuclear missiles to contain the infection.
** ''[[VideoGame/ResidentEvilGunSurvivor Resident Evil: Dead Aim]]'' had the cruise liner that served as the setting for the game blown up by a KillSat by the Chinese government.
** TheMovie spin-off ''Anime/ResidentEvilDegeneration'' actually averts this scenario with the main outbreak at an airport, but the [=WilPharma=] pharmaceutical laboratory is destroyed in a ''spectacularly'' elaborate self-destruct sequence.
* In ''VideoGame/{{Prototype}}'', Manhattan is set to be destroyed by a nuclear bomb after the Blacklight and Redlight viruses have run amok. [[spoiler: The player character Alex Mercer averts this by personally flying the bomb away from Manhattan, dumping it into the river and sacrificing himself in the process. [[FromASingleCell He gets better.]] So does New York, despite seemingly the entire city being infected by the end of the game.]]
** In ''VideoGame/{{Prototype 2}}'', the government tries again, using [[spoiler:thermobaric rockets fired from helicopters. They fail again.]]
* ''VideoGame/MetroidFusion'' double subverts this. When the BSL Station is overrun by the X Parasite, Samus plans to activate the station's self-destruct to kill all of them aboard. However, her AI informs her that this doesn't guarantee she'll kill ''all'' the X Parasites, just the ones aboard the station, [[spoiler:so it recommends causing the station to fall out of orbit so that its self-destruct field also destroys the planet, ensuring all the X die.]]
* The Covenant in ''{{Franchise/Halo}}'' doesn't stop at nukes when it comes to Flood outbreaks. They bombard the entire planet with plasma until rock and sand starts to melt and is transformed to volcanic glass. Earth gets spared this treatment due to the Arbiter advising Half-Jaw against it, though half of Africa is still glassed.
** The Halos themselves are the Forerunners' execution of this trope, killing all non-Flood life in the galaxy to ensure the Flood has no food.
* The plot of ''VideoGame/FinalFantasyXIII'' starts with an ancient being awakening in a tomb that was assumed to be empty, and immediately starting to force locals into its service. To contain the curse, the entire population is to be deported to the main planet their world is orbiting and which is the home of the ancient beings, but it soon becomes obvious that the people in charge don't really intend to let anyone remain alive.
** In ''VideoGame/FinalFantasyX'', upon fleeing their home on a CoolAirship, the Al Bhed feel that the best way prevent the enemy occupiers from getting their hands on their technology is to [[ThereIsNoKillLikeOverkill blow the entire facility up with nuclear missiles]].
* One of the possible methods by which you defeat the [[BigBad Naughty Sorceress]] in ''KingdomOfLoathing''. After you counter her first two attacks with [[spoiler:the Wand of Nagamar]], [[OneWingedAngel her final form]] attacks you with a [[SignificantAnagram HEARTBREAKING TOFU MOUSSE]]. You counter ''[[RuleOfThree again]]'' with the same thing, and [[spoiler:[[SignificantAnagram NUKE THE SAUSAGE FROM ORBIT]]]]. [[ShoutOut After all, it's the only way to be sure.]] Referencing the TropeNamer is a bit of a RunningGag in that game.
* In ''VideoGame/HalfLife1: Opposing Force'' Black Ops assassins trying to blow up alien-infested facility and cover up the whole Black Mesa incident use a [[http://half-life.wikia.com/wiki/Mark_IV_Thermonuclear_Device fusion warhead]] they removed from a nearby missile. [[PlayerCharacter Shephard]] kills them and deactivates the device, but later the G-Man sets up its timer again.
--> '''The G-Man''': The biggest embarrassment has been Black Mesa facility, but I think that's finally taken care of itself... quite so.
* In ''VideoGame/DeadRising2'', the military plans to destroy Fortune City by firebombing [[spoiler:when a team sent in to rescue the survivors is wiped out]]. It's never shown in the best ending.
** Inverted in ''VideoGame/DeadRising''. Carlito (the villain) wants to blow up the mall to ''spread'' the virus rather than contain it, and you have to stop him.
* In DawnOfWar II: Retribution, the Inquisition executes the Exterminatus (explained in Tabletop section) to prevent a planet from being seized by an emerging Demon Prince. [[spoiler: They are a bit too late and not so thorough]].
* In ''{{Starcraft}}'', right before the first game, the Protoss incinerate ''a planet'' because it was overrun by the Zerg. The same thing happens another few times (off-screen) during the Terran campaign. The Protoss executor Tassadar abandons this tactic though, because he feels bad for all of the Terrans that die in the process.
** In [=SC2=] Wings of Liberty, Selendis wants to do this to an infested colony, albeit less drastically than the ones in the original. Instead of incinerating the entire planet, her method is vaporising the (potentially) infested parts.
** And at the beginning of the game, Raynor states that it apparently didn't work - new dens are found out there all the time.
* ''VideoGame/MassEffect1'': The research facility on Noveria includes a safety mechanism in the so-called "hot labs" that initiates a neutron bomb explosion and sterilizes the labs, to contain outbreaks. There's also a more comprehensive system that shuts down environmental control throughout the facility and sinks it deeper into the ice shelf, letting the conditions kill off anything hazardous. Similarly, this approach is also taken with Saren's facility in Virmire with the Salarians converting their ship's drive core to a makeshift nuclear device.
** In the sequel ''VideoGame/MassEffect2'', everyone except the Illusive Man thinks blowing [[spoiler: the Collector Base]] is the only practical solution to prevent the mind controlling effects of Reaper technology from creating new minions that serve them. [[spoiler:Which turned out to be futile, since the Illusive Man already had implanted himself with reaper technology years before, but at least it significantly slowed him down.]]
** Depending on what you make of [[GainaxEnding the ending]] in ''VideoGame/MassEffect3'', the "Destruction" option is just that. Even [[UnreliableExpositor if the claims are true]] that it will also [[spoiler:destroy all [[PortalNetwork Mass Relays]], erradicate the Geth, and kill [=EDI=]]], it's the only chance to permanently putting an end to the threat.
* In the [[AllThereInTheManual backstory]] of ''VideoGame/{{Nier}}'', the White Chlorination Syndrome epidemic (a disease caused by the magic from the ''VideoGame/{{Drakengard}}'' world, specifically the EldritchAbomination, entering the modern world in Ending E of the first game) is slowly spreading across Japan. A huge wall --the wall of [[MeaningfulName Jericho]]-- is erected to contain the disease and the infected. When it starts creating horrible monsters called Legion, the US military drops a nuclear bomb on it... [[NiceJobBreakingItHero spreading the infection]] [[TheEndOfTheWorldAsWeKnowIt worldwide]].
* This is the standard, ''human'' way to deal with demonic invasion in ''Franchise/ShinMegamiTensei''.
** The one that started it all: in ''ShinMegamiTenseiI'', the combination of a military coup and the appearance of wild demons in Tokyo (and the former weaponizing the latter) leads to the United States bombarding the city with nuclear weapons. It is revealed, however, that it was actually [[spoiler:a plot by the Law-aligned Ambassador [[MeaningfulName Thorman]] and the CouncilOfAngels to wipe the slate clean in order to start building the Thousand-Year Kingdom of God]], using the demon invasion as the perfect window of opportunity.
** In ''Shin Megami Tensei: VideoGame/DevilSurvivor'', the wards of Tokyo encircled by the Yamanote train line are sealed off to prevent escape of either the demons or the people in contact with them. [[MultipleEndings If all attempts to save the city fail]], everything inside it is ''fried''.
** In ''VideoGame/ShinMegamiTenseiStrangeJourney'', when it seems the reconnaissance teams sent to explore the [[NegativeSpaceWedgie Schwarzwelt]] have vanished and failed, the assembled world governments acting under the Schwarzwelt Investigation Project [[spoiler:actually DO this, by bombing the HellGate with nuclear weapons... and it fails. Nothing can stop the Schwarzwelt from expanding]]. However, the teams trapped inside it devise a plan to [[spoiler:use their own nuclear weapons (strapped to {{Cosmic Keystone}}s of world-creating or world-ending power) to nuke the portal from the ''inside'']].
* Threatened in ''VideoGame/MetalGearSolid'' and ''VideoGame/MetalGearSolid3''--but it's less a tactic to neutralize a threat and more to dispose of pesky witnesses and incriminating evidence (though there is some of the former, too).
* ''[[FirstEncounterAssaultRecon F.E.A.R.]]'' has this happen at the end of the first game, [[spoiler:in a desperate attempt to kill the now-freed Alma. To everyone's horror, it completely fails to affect her.]]
* ''VideoGame/DeadIsland'' averts this trope. Ryder White intends to call in a nuclear strike on the island of Banoi to burn out the infection. [[spoiler:White fails to carry out his plan due to mutation and death.]]
* In Creator/{{Bungie}}'s ''VideoGame/{{Myth}}'' series, the forces of light tend to do this whenever they're able to defeat the current incarnation of [[BigBad The Leveller]]. Things done to its host include: Beheading him and throwing the head into a [[BottomlessPits bottomless pit]]; Beheading and cremation; Having him drawn and quartered with the various parts scattered across the continent; Burning the body, mixing the ashes with salt, and then burying it all underneath a mountain.
* In ''VideoGame/TheColony'', [[spoiler:this is your goal after rescuing the survivors of a transdimensional alien invasion.]]
* In ''[[VideoGame/XComEnemyUnknown XCOM: Enemy Within]]'', there is the Council Mission known as Site Recon. A village in Newfoundland is so badly overrun by Chrysallids that Central decides it best for your field team to mark the site for a saturated bombing run and then get out of there.
[[/folder]]

[[folder: Web Comics ]]

* In ''Webcomic/SchlockMercenary'', Tagon quickly remembers that encouraging his MadBomber's eager paranoia is a bad idea when he asks for ways to defend Northport.
-->'''Pi:''' There are so many possibilities... I'd have to requisition some ordnance, sir.
-->'''Tagon:''' You are ''not'' allowed to nuke Northport ''"Just to be sure."''
-->'''Pi:''' I'd have to nuke a lot more than just Northport to be ''really'' sure.

[[/folder]]

[[folder: Web Originals ]]

* The short-lived live-action web series ''Dead Patrol'' involved military teams tasked with delivering nuclear warheads to zombie-infested cities - by truck, [[FridgeLogic for some reason]].
* The ''[[http://digg.com/newsbar/topnews/Alomal-137_Case_Study Alomal-137 Case Study]]'' by Lon Miller briefly describes nuclear annihilation of several east-coast cities in response to a pandemic.
* The game [[http://www.hardcorepawn.com/zombie3/ Zombie 3]] requires the player to bomb entire city blocks to stop a spreading zombie infestation. Depending on the player's skill, it may be easier to protect a small enclave of survivors and carpet-bomb the rest of the city as a precaution.
* Several sites run by the ''Wiki/SCPFoundation'' that house their more dangerous anomalies feature a tactical nuclear warhead or three as part of their structures. This is in case of a break-out, since "these things NOT running amok" is of a higher priority than "Contain, not destroy." In several instances, it's explicitly stated that the nukes wouldn't even destroy the objects, just slow them down enough that re-containment would be possible. Maybe.
[[/folder]]

[[folder: Western Animation]]
* In ''ReBoot'' the Guardian Collective takes this approach to dealing with web creatures. They don't even ''try'' conventional methods to get rid of them, opting to destroy the system as soon as one is found. Bob knows about this and is pissed when he sees Mouse tell the guardians about the web creature in Mainframe. Bob manages to stop this, [[FromBadToWorse but makes the situation worse]].
* In ''ClerksTheAnimatedSeries'', Leonardo Leonardo plans to takeover the town. Dante and Randal find a book detailing his master plan, which is full of counter-measures for every possibility. If things spiral completely out of control, the city is to be nuked from orbit. Randal even invokes the trope name.
[[/folder]]

[[folder: Real Life]]
* Declassified materials from the US Department of Defense seems to indicate this is an official position of last resort on many biological weapons. Apparently, this is one of the few cases where use of nuclear weapons on friendly (or home) soil is both planned for, and expected to be used should the conditions arise. A confirmed smallpox outbreak which can't be contained is one such scenario.
* While not confirmed, most other nuclear powers are expected to have similar contingency plans, and many non-nuclear nations have either a conventional form of this, or agreements with nuclear powers to perform this action upon request.
[[/folder]]

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