->''"You see, insanity runs in my family. It practically gallops."''
-->-- '''Mortimer Brewster''', ''Theatre/ArsenicAndOldLace''

A family full of eccentric, weird and sometimes insane relatives. Preferably all of them, but as long as it's the majority of them then it's okay. Commonly it's all of them except [[OnlySaneMan one perfectly normal one]].

Someone may observe their..."activities," but when they confront the family about this, the said family will often have no idea that they are considered to be out of the ordinary.

See also BigScrewedUpFamily. InTheBlood is the darker version of this, while HeroicLineage is the more... well, heroic version. Contrast TurnOutLikeHisFather. Compare SharedFamilyQuirks.


[[folder:Anime & Manga]]
* The Trinity siblings/Gundam Thrones. of ''[[Anime/MobileSuitGundam00 Gundam 00]]'' Michael is AxCrazy, Nena's CuteAndPsycho and Johann is TheStoic: they believe they are creating a better world... despite the fact [[KnightTemplar they attack non-active militants and innocent civilians]]. As do the protagonists, for that matter, only they at least ''try'' to involve the civilians less.
* The hero's three sisters in ''Manga/{{Magikano}}.''
* ''[[Anime/AfterWarGundamX Gundam X]]'''s Frost Brothers, Shagia and Olba.
* The Toguro Brothers from ''Manga/YuYuHakusho''.
* The ''Manga/RozenMaiden'' dolls.
* The Kunos in ''Manga/RanmaOneHalf'' are all totally bonkers. In the manga (the story wasn't converted to the anime), it's revealed that having NoSenseOfDirection is something that runs in Ryoga's family -- his mother and father are just as bad as he is. Some fans have even [[PoisonOakEpilepticTrees theorized]] that [[{{Squick}} his parents are brother and sister]] due to this.
* [[VisualNovel/UminekoWhenTheyCry The Ushiromiyas]]. Kinzo is [[MadLove dangerously insane]], Eva is a RichBitch who [[spoiler:goes totally AxCrazy in one arc]], Rosa is an [[AbusiveParents abusive]] single mother, and her daughter Maria is an extremely CreepyChild who may give her grandpa a run for the money in the "crazy" department. [[spoiler:Natsuhi]] is downright delusional, [[spoiler:and she ''married'' into the family]]. The rest are also neurotic, just less... violently so. Oh, and [[spoiler:at least six]] of Kinzo's descendants have been seen to use magic, [[MaybeMagicMaybeMundane if you take the Anti-Mystery perspective]]. It's more than [[BigScrewedUpFamily dysfunctionality]] and CuteLittleFangs that runs in this family.
** Even the at least vaguely sane Battler is [[spoiler:starting to act like his grandfather.]]
* ''LightNovel/ACertainMagicalIndex'':
** Anyone, ''anyone'', in who is in any way related to the Kiharas can be easily identified not only as evil scientists, but as batshit insane, downright monstrous evil scientists.
** Apparently ChickMagnet runs in the Kamijou family.
* ''Anime/CodeGeass'':
** Everyone -- ''everyone'' -- on the show arguably [[spoiler: goes insane]] by the end, but the Emperor's line is the most [[IncrediblyLamePun screwy]] of all, in both mind and manipulation.
** Lelouch. [[spoiler: Charles.]] Schniezel. [[spoiler: Marianne. Euphie, and Nunnally even.]] They're all [[WellIntentionedExtremist well-intentioned extremists]] bent on taking over the world for the greater good. The only family member who gets sufficient screentime and doesn't count is Cornelia, and she still gets introduced conquering a part of the world. It most definitely runs in the family.
* ''Manga/{{QED}}'': Touma's family are in general {{Cloudcuckoolander}}s and are geniuses in one field or another.
* Though we've only seen the female half of the Saginomiya family in ''Manga/HayateTheCombatButler'', they're all pretty well {{Cloudcuckoolander}}s. Isumi is the closest one to sane, and she barely qualifies as such.
** Isumi's grandmother mistakes her daughter, Isumi's mother, for Hayate when meeting him for the first time. And the mother thinks she actually is! Even wondering where she went when the grandmother changes paths.
* ''Manga/FullmetalAlchemist'': '''THE [[LargeHam LARGE HAMMINESS]], [[IdiotHair IDIOT HAIR]], [[CharlesAtlasSuperpower CHARLES ATLAS SUPERPOWER]], AND [[BishieSparkle SPARKLES]] HAVE BEEN PASSED DOWN THE ARMSTRONG FAMILY LINE FOR ''GENERATIONS!!!!'''''
* ''LightNovel/{{Oreimo}}'': Both Kirino and Kyousuke are {{Tsundere}} in their own ways. However, both of them ''clearly'' get it from their father.
* Shinichi's father in ''Manga/DetectiveConan'' is a mystery writer who doesn't investigate because he's BrilliantButLazy. Fellow detective Heiji's father is a well-known police investigator. Haibara's parents are scientists.
* ''Manga/InuYasha'': {{Youkai}} view compassion for [[ToServeMan humans]] as eccentricity at best and [[LoveIsAWeakness weakness]] at worst. Even the great Dog Leader was brough down by his compassion, an "infection" Sesshoumaru blames Inuyasha's human mother for even though Myouga states he was genuinely compassionate. Eventually, even Sesshoumaru succumbs to the family "curse" causing his mother to observe he's turned into his father.
* For Kakuma Keita in the anime adaptation of ''VideoGame/InazumaEleven'', being a LargeHamAnnouncer runs in the family. It helps that his father is a professional TV announcer for soccer matches.
* In ''LightNovel/ThePetGirlOfSakurasou'', Chihiro uses this to explain away resident IdiotSavant Mashiro's behaviour, and [[ThereAreNoTherapists did not suspect the latter]] [[WordOfDante may have some kind of mental disability]].
* ''Manga/OnePiece'': Luffy and his father [[spoiler:Dragon]] are the only known people to have [[spoiler:'''declared war upon the World Government''']] and gotten away with it. Completely unrelated to each other. [[spoiler:Dragon]] is also leading an active rebellion.
** Those who have D as a middle initial have a tendency to GoOutWithASmile, which is called the "Will of D". So far, the only exception is Marshal D "Blackbeard" Teach, which Whitebeard takes to mean that Teach is ''not'' a true inheritor of the Will. However, it's unclear just how the various D's are related.
** All of the introduced members of the Vinsmoke family seem to be perverts with the men being the worst.
* ''LightNovel/{{Baccano}}'''s Laforet family is a proud family line consisting of {{Mad Scientist}}s, [[KnifeNut knife-wielding]] [[LoveMartyr fanatics]], {{Enfante Terrible}}s and, [[spoiler:once Claire finds his way into the bloodline]], [[TheAce hypercompetent]] [[InsufferableGenius but insufferably arrogant]] solipsistic teenage girls. Only one can arguably be considered reasonably sane (Luchino Campanella), and he's a teenage assassin.
* In ''Manga/ServantXService'', as Yutaka Hasebe's sister Kaoru mentioned, the entire Hasebe family are (1) civil servants and (2) share extreme BrilliantButLazy / TheSlacker traits. Yutaka, who as at first seen as a loser if not for his HiddenDepths, is indeed the ''most downplayed'' in terms of this trait.
* In ''Manga/MagicalGirlLyricalNanohaVivid'', when Einhart relates what GeneticMemory she has of Wilfried Jeremiah and mentions the part about Reid [[TheDrifter coming and going for long periods of time]], Victoria snarks that Sieglinde seems to have inherited that trait from her ancestors. Victoria also mentions that the Jeremiahs are a nomadic tribe, which helps explain this tendency of theirs.
* Loz, Yazoo, and Kadaj from ''Anime/FinalFantasyVIIAdventChildren''. Like their Father, they all want to help their Mother Jenova in whatever they can. If that includes threatening Formerly Corrupt Corporate Executives, Kidnapping Children, and summoning a Dragon to destroy a City, all the better!
* PlayedForLaughs in one chapter of ''Manga/{{Horimiya}}'' when Miyamura ends up getting asked the exact same question by Hori, her father, and her brother in rapid succession. The inside cover of volume 10 shows that they've actually started rubbing off on him due to how much time he spends at their house.

[[folder:Comic Books]]
* The [[Franchise/MarvelUniverse House of M]], currently made up of Magneto, Quicksilver, the Scarlet Witch, and Polaris (probably), All of them pretty much known for periodically leaving their sanity at home. The third-generation kids may or may not be affected, but so far they're... mostly doing well.
** Except for the ones who may or may not have just been a physical manifestation of [[RealityWarper Wanda's]] psychosis.
** Oh, and the one who's currently being treated for an addiction to the Inhumans' Terrigen Mists.
*** Which her father got her hooked on after taking a few hits himself.
* ''{{Deadpool}}'', a SociopathicHero hooks up with Shiklah, an evil Succubus who's crazier than he is. Both have shown an attraction to one another's violent sides. Their relationship was as stable as one could expect. They can be lovebirds one minute , and literally going to war with one another the next, while having sex in the middle of that. They have a daughter together sometime in the future. Needless to say their daughter, Warda is just as violent as both of her parents. She doesn't have a high opinion of Deadpool, held him hostage and tortured him for years trying to get info on what he'd done with Shiklah, while also causing another war. Deadpool's first child, Ellie, fights against her. While Ellie isn't as crazy as Deadpool or her half-sister, she is not shy to solving problems through violence. Even as a kid, she got into many fights after changing schools, with Deadpool encouraging her to tell teachers about bullies, instead of fighting. But no luck.
* In ''ComicBook/AllFallDown'', IQ and IQ Squared are both lonely, brilliant, irritable men who find it impossible to talk to each other.
* In certain stories, we learn that [[Franchise/ArchieComics Archie Andrews']] ancestors were just as girl-obsessed and clumsy as he is.
* ''Comicbook/LaffALympics'':
** Dastardly Dalton says so when Dread Baron's brother Dick Dastardly says he never won any "of those WesternAnimation/WackyRaces".
** A page in the comics describes the Creeplys as direct descendants of the Gruesomes and states that, like their ancestors, like gloomy weather, ants at picnics and monster movies where the monster wins and hate rock music.

* In Chapter 14 of the ''WesternAnimation/{{Superjail}}'' fanfic [[http://www.fanfiction.net/s/8803490/1/Extended-Stay Extended Stay]], it is revealed that the Warden and the Mistress's children Matilda and Ethan have grown up to be sadists like them. Combined with TroublingUnchildlikeBehavior.
** Actually, they're 4 years old, but still...
* This is an assumption if Sayu knew if Light was Kira and continued his work. A couple have Ryuk be her Shinigami, only one or two have Light reincarnated as a Shinigami himself.
* In ''Fanfic/BlackkatsReverse'', Sarutobi is quickly persuaded that Uzumaki Kurama really is a Uzumaki, for the good reason he left an unholy amount of trouble in his wake.

[[folder:Films -- Animation]]
* The Sanchez family from ''WesternAnimation/TheBookOfLife'' boasts three main traits.
** The first is bullfighting. And, as Carmen [[DeadpanSnarker points out]], it is why there are so many Sanchezes in the Land of the Remembered, as they were all killed in the ring.
** The second is music. Manolo has an ancestor several generations back who wanted to be an opera singer but was pushed into bullfighting. As such, he sympathizes with Manolo, and even gets one heck of a solo in the big final battle. (Fittingly, he is voiced by Placido Domingo!)
** The [[RuleOfThree third]] is a certain unflinching courage. It could be argued that Manolo got his due to La Muerta's blessing. But his mother, Carmen, on meeting Xibalba, bitchslapped him.
* Bill's family in ''{{WesternAnimation/Its Such A Beautiful Day}}'' is a very good contender for the MostTriumphantExample, with examples of mental illness and insanity going back for at least ''four'' generations before him. To recapitulate:
** His great-great-great uncle was a WildChild who once beat a church organist with a shovel.
** His great-grandmother had hallucinations of phantoms.
** His grandmother rubbed severed cat heads on her skull because "the fish are smothering her brain"
** His great-aunt beat imaginary animals with a hammer.
** His great uncle was a preacher who grew his mole hairs "to cleanse is soul" and believed a sea monster stole the sherrif's cow.
** His mother shaved the cat on weekends and forced Bill to wear a heavy coat year-round in order to protect him from "walking pneumonia".
** His brother Randall suffers from mental retardation and eventually runs into the sea and drowns.
** Bill himself is the victim of psychotic episodes and eventually suffers from acute amnesia.
* The eponymous family from the film ''Disney/MeetTheRobinsons'' are all eccentric verging on insane.

[[folder:Films -- Live-Action]]
* Averted in ''Film/BigGame''. Oskari ''wishes'' that he was as good a hunter as his father and rest of his family is.
* The Family Firefly from ''Film/HouseOf1000Corpses'' and ''Film/TheDevilsRejects''.
* ''Film/TheHouseOfYes'' only shows four members of the Pascal family but they all have some severe issues. Not to mention that it is hinted that [[spoiler: Mrs. Pascal killed her husband, which echoes the climax of the film.]]
* The Portokaloses of ''Film/MyBigFatGreekWedding''.
* The Merrye clan of ''Film/SpiderBabyOrTheMaddestStoryEverTold'', who suffer from a degenerative disease that causes them to become murderous, insane cannibals. Played for nervous, {{squick}}y laughs.

* Inverted in ''Literature/ASeriesOfUnfortunateEvents'': the Baudelaire siblings are the only people who aren't insane, evil, or completely oblivious.
* The Bagthorpes, in the children's novels by Helen Cresswell (they start with ''Ordinary Jack''). Tess, Rosie and William are all somewhat eccentric, and their parents and grandparents might edge into mildly deranged, as might their cousin Daisy... They all (well, except Daisy) believe wholeheartedly in their genius as a family and individually, and take themselves very seriously. In one of the books in the sequence, they try to break as many Guinness World Records in a summer as they can...
** And in keeping with the trope, Jack and his ally Uncle Parker are the only sane ones people can bear to have anywhere near them. Also Grandpa (though he's less developed as a character).
* ''Literature/HarryPotter''
** The Weasleys are one big kooky red-headed family who are implied to be quite old and presumably extensive, as females are very rare in their line. There's only one Squib, who Ron reveals to be an accountant.
** The Black family? Many are completely insane. Sirius claims that if they turned out anybody half-decent they were blasted of the Family Tree.
* The [[Literature/VorkosiganSaga Vorkosigans]]:
-->'''Cordelia''': Counts Vorkosigan have come to horrible ends throughout your history. You've been blown up, shot, starved, drowned, burned alive, beheaded, diseased, and demented. The only thing you've never done is die in bed.
** Count Piotr, the guy Cordelia was talking to and the 10th Count Vorkosigan, was the first to actually accomplish that last one: dying in bed at an advanced age. Miles Vorkosigan (whose own mother explicitly states is not quite sane, if only to cope with the insane amount of expectation and social pressure that have characterized his entire life) has also got a lot of other crazy people in his family tree, especially from the Vorrutyer and Vorbarra branches of the family.
* Subverted in the ''Series/DoctorWho'' Literature/EighthDoctorAdventures novel ''The Taint'': Fitz's maternal relatives are mostly more or less insane. It turns out it's due to alien brain slugs, which the Doctor deals with. It seems, however, that Fitz has a slightly different view of matters, as in one or two later stories, he thinks he's hallucinating and blames it on the craziness that runs in his family, even though he hasn't got a brain slug any more. Naturally, he's not hallucinating.
* The Pendergasts, in the thrillers of Douglas Preston and Lincoln Child, have a strong streak of insanity in the family. Sometimes this takes the form of a [[BunnyEarsLawyer brilliant, unorthodox]] approach to [[DefectiveDetective investigating crime]]. More often, it takes the form of [[ScienceRelatedMemeticDisorder finding novel ways]] to [[KillEmAll wipe]] [[InsaneEqualsViolent out]] [[NietzscheWannabe humanity]].
* The Smedry family of the ''Literature/AlcatrazSeries'', in addition to having hereditary magical talents, have a reputation for extreme eccentricity.
* In Creator/GKChesterton's ''Literature/TheManWhoWasThursday'', it's mentioned in passing that Syme grew up in an extremely odd family and eventually got so BoredWithInsanity that he rebelled by being as sane as humanly possible. In fact, he's so sane that he's almost ''too'' sane, and therefore, in his own way, just as crazy as the rest of them.
* The Woosters in ''Literature/JeevesAndWooster'' are a pretty eccentric bunch in general, and at least one (Henry Wooster) spent his last days "in some sort of a home". For this reason, the "nerve specialist" Roderick Glossop has latched onto {{Cloudcuckoolander}} Bertie Wooster as insane and [[InsaneEqualsViolent potentially dangerous]].
* Literature/MaryPoppins and her relatives each have at least one mystical quirk.
* ''Literature/TheDresdenFiles'': magic runs in the family. It's a hereditary trait. But getting in trouble with vampires runs in Harry's family. Harry accidentally started a war between the vampires and the UN of Wizards, and his mother bore the bastard child of one. Also, generally getting in trouble with werewolves, wizards, demons, angels, and fae.
* The Igors (and Igorinas) in the ''Franchise/{{Discworld}}''series are not so much ''in''sane as ''differently'' sane. They're definitely eccentric, but they're competent enough surgeons that when an Igor says of another Igor "He has his grandfather's eyes" he's not speaking metaphorically.

[[folder:Live-Action TV]]
* Pretty much any reality show that involves some sort of family member swap. The shows will always show families that have weird quirks and the person who is swapping into that family usually finds it disturbing.

* ''Series/TheAddamsFamily'' as a case of a CreepyFamily.
* ''Series/{{Angel}}'': Connor seems to take after his father Angel in one respect. "A weakness for Slayers. You're ''definitely'' his son."
* ''Series/ArrestedDevelopment'' is about a family that has no idea how to live conservatively and act like decent human beings....except for Michael Bluth, who the family both counts on to keep them afloat and takes for granted.
* ''Series/BuffyTheVampireSlayer'': A gift for banter and sarcasm runs deep in Summers women, as shown by Buffy, her sister Dawn and their mother Joyce.
* ''Series/DoctorWho'':
** The Pond family is smaller than most examples, but has more wackiness than most small planets. Poor Rory seems to be the OnlySaneMan[[note]]Though you would be too if you had 2000 years of memories of protecting Amy and nothing can scare you any more[[/note]], as his wife spent her childhood biting psychiatrists, his daughter is a self-proclaimed psychopath, and his son-in-law puts the "crazy" in CrazyAwesome.
** In the ''AudioPlay/BigFinishDoctorWho'' and ''AudioPlay/{{Gallifrey}}'' audios, the Doctor's relatives Brax, Susan, and Alex[[note]]respectively his brother, granddaughter and great-grandson[[/note]], have a habit of being reckless, independent, highly intelligent, and self-sacrificial. [[spoiler:The latter costs poor Alex his life when he is only twenty years old.]] Special mention goes to Brax for also having a tendency to lie to his friends to keep them safe. Sound familiar?
* Kenny's family in ''Series/KennyVsSpenny'' are all pure ''evil''. At one point the entire clan comes together to fake Kenny's mom's death and hold a fake funeral and going in mourning just to keep Spenny from winning a footrace.
* ''Series/LazyTown'''s Stephanie is the only character in the show who has bright pink hair. But according to her uncle, it's a trait that runs in the family.
* Malcolm's family from ''Series/MalcolmInTheMiddle'' fits this perfectly, in a beautifully dysfunctional manner.
* ''Series/TheMunsters'' are all members of the MonsterMash and are considered weird...except for human-looking Marilyn--who was considered ugly by the rest of her family (though she shares some of the other members' inhumanness like her very low body temperature).
* This trope was the name of an episode of ''Series/MurderSheWrote'' featuring Jessica's British cousin Emma (also played by Angela Lansbury); she's just as much a DoomMagnet (and just as much a sleuth) as her cousin.
* The Winchester-Campbells in ''Series/{{Supernatural}}''. Hunting, making deals with demons, coming back from the dead...

* Amanda Palmer's "Runs in the Family" describes people who have inherited various complications from their bloodlines (''My friend has maladies/ Ricketts and allergies/ That she dates back to/ The seventeenth century'') and goes on to talk about her own family.
* Music/TheWho, ''[[{{Quadrophenia}} The Real Me]]'':
-->I went back to my mother\\
I said I'm crazy ma, help me\\
She said I know how it feels, son\\
'Cause it runs in the family

[[folder: Roleplay]]
* A fairly minor case PlayedForLaughs in Roleplay/DinoAttackRPG. Sarah Bishop gained a particular infamy among the cast when she became the first known person to hate the [[SupremeChef Brickolinis']] pizza (though Pierce ''might'' also count, or he may just have eaten a particularly hot one). Sure enough, a few posts later, it turns out her daughter Kate can't stand the taste of Brickolinis' pizza either.
** The Alexander family has an aversion to aging, which is one of the few things that [[LongLostRelative Dr. Rex and Katerina Schattenberg]] have in common.

* The d'Ambrevilles of Glantri in the TabletopGame/{{Mystara}} D&D setting are a large and fractious family of wealthy, self-indulgent, scheming and often magically-gifted weirdos. They were even stranger in the adventure (Chateau d'Ambreville) that introduced them, having been trapped in a bizarre PocketDimension for years; many had turned single rooms or suites within their cursed mansion into their own private gardens/laboratories/banquets/whatever, and had been physically transformed by curses to have the heads of animals.

* The Sycamore family from ''Theatre/YouCantTakeItWithYou''.
* The Brewster family in ''Theatre/ArsenicAndOldLace''. The one family member who's not insane, murderous or both is Mortimer. [[spoiler:He eventually learns, to his relief, that he's not a blood relative.]]

[[folder:Video games]]
* Caulder/Stolos's "children" in ''VideoGame/AdvanceWars: Days of Ruin/Dark Conflict''. Cyrus is fairly levelheaded, but Penny/Lili and Tabitha/Larissa... notsomuch.
* The Magus Sisters from ''VideoGame/FinalFantasyIV''.
* The Royal Family and all their Cousins/Second Cousins/Distant Cousins in ''VideoGame/KatamariDamacy''.
* The Sasaki family of the ''Franchise/MetalGear'' series have always been some {{Ineffectual Sympathetic Villain}}s who had some toilet problem of some sort.
* [[VisualNovel/AceAttorney The von Karma family]]. It's subtle, but if you pay attention, Franziska von Karma from the second game onward shares the same poses for her sprites as her father Manfred from the first game. Less subtly, both are prosecutors with obsessions for absolute perfection [[spoiler:(and although Franziska eventually gets over it, she does maintain the no-nonsense sense of authority that had come with it)]].
** [[spoiler: Edgeworth]] is a good example of this as well in the fourth case. The outfit is ''very'' similar to Manfred's, and the fingerwag is shared by both.

* The River family from ''Webcomic/IrregularElis''. A Spanish webcomic about a BadassFamily of [[{{superhero}} Superheroes]] with a lot of Creator/HannaBarbera influences.
* In ''Webcomic/TheFancyAdventuresOfJackCannon'', we have seen three members of Jack's family so far: Him, his Mum, and his Dad. Each of them is a badass.
** Jack can dodge flying knives, grab them from the air, and throw them back at whoever threw them in the first place. He can also punch his way out of the ground.
** Mom is an ex-agent who beat up Jack's dad when they first met and tried to take him hostage. She randomly throws knives at her son and puts poison in his cereal (among other things) to teach him how to defend himself from attacks both subtle and direct.
** Dad is an ex-agent who almost beat up Jack's mom when they first met and she tried to take him hostage. He wears Kiss The Cook aprons, yet likes to single-handedly grab foes by the head and throw them at one another.
* In ''Webcomic/GirlGenius'' Spark, which might be better known as ScienceRelatedMemeticDisorder, tends to run in families. It's probably the most apparent in the Heterodynes, a house full of powerful Sparks and vicious warlords who terrorized Europa for centuries.
* In ''Webcomic/UndyingHappiness'', Keisuke's HealingFactor, [[FeelNoPain immunity to pain]], and [[TheKlutz clumsiness]] appears to be hereditary: his grandmother has it (and laughs off [[spoiler: [[{{Fingore}} accidentally slicing off the fingers of her left hand]]]]) and the TimeSkip shows his son Yusuke has it as well.

[[folder:Web Originals]]
* In the Wiki/TVTropes original webseries ''WebVideo/EchoChamber'', [[{{Cloudcuckoolander}} Zack's]] entire family seems to be severely messed up.
** Zack keeps a dead cat in a box.
** His dad is a [[MyBelovedSmother control freak who screwed up Zack's childhood]], and keeps him [[ManChild forever at that level of emotional maturity]].
** His Uncle Bill [[DontExplainTheJoke insists on telling a story]] [[ToiletHumour about how Zack once pooped himself while playing in a sprinkler]]. [[spoiler: [[DepartmentOfRedundancyDepartment His "story" is simply him repeating the already-stated fact that Zack pooped while playing in a sprinkler.]] This happened not when Zack was a kid, but around three years ago, when, [[UnreliableNarrator according to Zack]], he ought to have been studying for his Ph.D.]]

[[folder:Western Animation]]
* In ''WesternAnimation/AvatarTheLastAirbender'', the royal family of the Fire Nation have a tendency to be sociopathic nutjobs. For some odd reason it only seems to happen to one family member per generation, unfortuanetly, until the last two generations that one person was the eldest son.
* ''WesternAnimation/GravityFalls'': Pretty much the entire Pines family is rather careless about safety when there's adventure in play. Mabel runs around with a grappling hook and an axe, Dipper can just wander off into the woods when Grunkle Stan is not looking, Stan has made counterfeit money, is a [[spoiler:persona non grata in multiple states, stole radioactive waste]] and thinks bears should drive, and finally [[spoiler:Ford thinks giving weapons to children is valid, which can kind of be justified seeing he [[FishOutOfTemporalWater hasn't been in this dimension for a very long time]]]].
** As such, the making of [[spoiler:fake ID's]] is also a family thing.
* Poopeye, Peepeye, Pipeye and Pupeye, WesternAnimation/{{Popeye}}'s nephews.
** Plus Junior from ''Popeye and Son''. He has his father's strength, "[[WesternAnimation/FamilyGuy tumor arms]]", and speech impediment.
* In ''WesternAnimation/TheSimpsons'' all Simpson men are born intelligent, but suddenly become idiots at the age of eight.
* ''WesternAnimation/SouthPark''. If "Butterballs" is anything to go by, child abuse runs in Butters' family.
** In "Merry Christmas, Charlie Manson", the boys spend the holidays with Cartman's relatives. Not only are they all as fat as he is, they also have the same whiny voice and {{jerkass}} tendencies. (The only exception being Cartman's own mother, who is of average weight and generally nice, whatever her [[HookerWithAHeartOfGold other faults]].)
* ''WesternAnimation/TotalDramaIsland'' implies [[GenkiGirl Izzy's]] family may be like this:
-->'''Izzy:''' Genius runs in my family. ''AND'' psychotherapy!
* In the ''WesternAnimation/{{Futurama}}'' episode "A Fishful of Dollars", off of Leela questioning Fry's sanity, Professor Farnsworth claims madness runs in his family. Given what we see of Fry's family (Particularly, his CrazySurvivalist father), he just might have something.

[[folder:Real Life]]
* TruthInTelevision. Families often have quirks others find weird.
* A possible explanation for Music/MichaelJackson's extensive plastic surgery is because he didn't want to look like his abusive father.
* The Durrell family, if youngest son Gerald is to be believed, were all amiably eccentric, with a few downright barmy older relatives. See ''Literature/MyFamilyAndOtherAnimals''.
* Left-wing ideologies and a love for the theatre run in the Redgrave family, as seen in Sir Creator/MichaelRedgrave, his daughters Creator/VanessaRedgrave and Lynn Redgrave, and his son Corin Redgrave. Other members of the Redgrave dynasty include Creator/NatashaRichardson, her sister Joely (both Vanessa's daughters), and Jemma Redgrave (Corin's daughter).

* A recent rage comic meme had an extremely overweight lady visiting the doctor. The doc tells her "Ma'am, I'm afraid you're morbidly obese." The lady says "I'm sorry, but obesity runs in our family." The doc comes back with "Lady, ''nobody'' runs in your family!"