[[quoteright:320:[[Film/LordOfTheRings http://static.tvtropes.org/pmwiki/pub/images/rsz_tumblr_mgkc4w79hg1s3p6mwo1_1280_7830.jpg]]]]
[[caption-width-right:320:[[ElvesVersusDwarves Elves and dwarves are enemies]], you say? Not this time.]]

->''"I don't mind having a demon friend."''
-->-- '''Fuka Kazamatsuri''', ''VideoGame/Disgaea4APromiseUnforgotten''

In everyday life you're unlikely to know anyone of a different species to yourself, besides pets, and however much you might love your furry/scaly/feathered friends, the relationship probably isn't quite the same as the one you have with your bipedal ones.

In fiction, this restriction is ''way'' more lax, especially in the realms of of Fantasy and Science Ficton. Those worlds are populated by a whole host of fantastic aliens, elves, werewolves, robots, vampires, and who ''knows'' what else. It's incredibly common for people of completely different species to become close friends. Since the majority of these creatures tend to have an intelligent on par- if not greater- than that of humans, it might be stranger if people of various species didn't develop some sort of kinship. Even for species that are AlwaysChaoticEvil, you can expect at least one individual to [[PlanetOfHats throw off his hat]] and say MySpeciesDothProtestTooMuch, thus joining the good guys.

Sometimes, in universes where the existence of other magical/advanced races are part of TheMasquerade, or there's a lot of FantasticRacism going on, these friendships might be more limited. This will usually allow people to comment how strange the hero(e)s' friendship is.

See InterspeciesRomance, when the relationship is closer than this. Sometimes overlaps with OddFriendship.
If they are not supposed to be friends, see ForbiddenFriendship.

LoyalAnimalCompanion is a Subtrope. See also AndroclesLion, ABoyAndHisX. One of these may lead to a MayflyDecemberFriendship.

----
!!Examples:

[[foldercontrol]]

[[folder:Anime & Manga]]
* Ash Ketchum and series mascot, Pikachu, from ''Anime/{{Pokemon}}''. Friendship, trust, and understanding between trainers and their Pokémon are recurring themes on the show.
** Jesse and James with Meowth. This is different than any of the other examples from this show because Meowth is treated more like a equal than a {{Mon}} or pet. This is probably because he is one of the few Pokémon that speak human.
* Rem ({{Shinigami}}) and Misa (human) of ''Manga/DeathNote''. Rem develops a platonic love for Misa and is even willing to die for her. Light (human) and Ryuk ({{Shinigami}}) also fall under this having a few VillainsOutShopping moments together, though they are of a more {{vitriolic|BestBuds}} type.
* ''{{Hellsing}}'' has Integra and Pip (humans) with Alucard and Ceres (vampires).
* ''WolfsRain'' had a pack of wolves and a genetically engineered flower-human hybrid.
* Kimba and Roger Ranger from ''Manga/KimbaTheWhiteLion''.
* Used in ''Manga/BlackJack'', with a human scientist who's a friend of Manga/BlackJack adopting his last experiment (a super-intelligent deer) and treating him like a brother. It soon went FromBadToWorse.
** Also between a young fisherman and a whale. Again, it got worse when the whale was blamed for the death of some fishermen. [[spoiler: Unlike the scientist and the deer, they get better.]]
* Manga/DragonBall: Goku and most of his friends. But a more prominent example is Gohan (Saiyan/Human hybrid) and Piccolo (Namekian), which looks more like an IntergenerationalFriendship, but Piccolo is [[YoungerThanTheyLook only four years older.]]
* Several examples of this trope exists in ''OnePiece''. The most notable being Tony Tony Chopper, a reindeer who is a member of the Straw Hat Pirates and a [[TrueCompanions dear friend]] to the other 8 Straw Hats, who are all human.
** Luffy and Jinbe, who is a fishman.
* Manga/AxisPowersHetalia: America and Tony, his alien friend. They've been shown hanging out and playing video games, and America goes to Tony for help regarding the Pict invaders in the movie.
** England and Norway with their respective magical friends might count as well.
* In ''{{Manga/Bleach}}'', Tousen and later his lieutenant Hisagi with the anthropomorphic wolf Komamura.
** Ichigo (human/shinigami) with Nel (Arrancar).
* The demon Chrono with his human allies in ''ChronoCrusade''.
* San (human) and her wolf brothers from ''PrincessMononoke''. And then there's her "mother", Morro.
* Natsume and most of his spirit/Youkai friends in ''NatsumeYuujinchou'', including a inukami (a wolf-like spirit) and a kitsune-kodomo (a child fox spirit).
* From ''YuYuHakusho'', there is Yusuke and Kuwabara (humans) and Kurama and Hiei (demons).
* Any friendship Mamoru in ''GaoGaiGar'' develops, as he is an [[HumanAliens alien.]]
* The titular ''Manga/InuYasha'', who is a half-demon, half-human, with Miroku and Sango, both humans.
* ''Anime/YuGiOhGX'': Any human and duel spirit friendship, such as Juudai and Hane Kuriboh, Manjoume and Ojama Yellow, or Hayato and Death Koala.
* The premise of ''Literature/ArashiNoYoruNi'' revolves around this idea. Though whether this crosses over to {{Bromance}} or InterspeciesRomance territory is up for interpretation, especially in the anime when they change Mei's gender
[[/folder]]

[[folder:Comic Books]]
* Mickey Mouse and Goofy.
* In the ComicBook/{{X-Men}} there is Kitty Pryde and Lockheed the Dragon, who is her friend, not her pet.
** Also in the X-Men there is Cyclops' father Corsair and the other Starjammers (except [[InterspeciesRomance Hepzibah, who is his lover]]), each of whom belongs to a different race (except for Sikorski, who is a robot).
** Longshot and Shatterstar - both from Mojoworld - and their teammates (except for lovers) on various X-teams.
** Warlock and the other New Mutants.
* Human Rick Jones and the Kree [[CaptainMarVell Captain Marvel]] (Mar-Vell as well as Genis-Vell).
* {{She-Hulk}} and Jazinda the Skrull.
* Most of {{Superman}}'s friendships qualify, though not necessarily Clark Kent's.
* The Wolfrider elves and their wolves in ''ElfQuest'', partly because they can exchange feelings telepathically, and partly because they're [[ItMakesSenseInContext related by blood]].
* ''{{Nextwave}}'' has a human, two superhumans, a mutant, and a robot.
[[/folder]]

[[folder:Fairy Tales]]
* From the Grimms' collection:
** "Literature/TheBremenTownMusicians": A donkey, a dog, a cat and a rooster form a happy company.
** "Literature/PussInBoots": A boy and his cat.
** "Old Sultan": An old dog, a wolf and a three-legged cat.
** "Dog and Sparrow": A tale of [[RoaringRampageOfRevenge vengeance (and how!)]] for a friend's death.
** "Literature/TheGooseGirl" and her horse Falada.
[[/folder]]

[[folder:Fanfiction]]
* Empath Smurf and Polaris Psyche in ''Fanfic/EmpathTheLuckiestSmurf''.
* Pretty much the plot of ''[[http://www.100megspop2.com/kayasps/main/mikehero.html Scar The Unsung Hero]]'' as the plot is Scar befriending a teenage human.
* "Human in Equestria" stories are a ''very'' common theme in ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' fanfictions. FishOutOfWater comedy or [[InterspeciesRomance romance]] stories are most common, but stories involving time travel, alien invasions, and just about everything have been done.
[[/folder]]

[[folder:Films -- Animated]]
* This is common in ''{{Disney}}'' and ''{{Pixar}}'' films:
** Mickey Mouse, Donald Duck and Goofy (dog?) going back to before World War 2.
** Genie [[ExactlyWhatItSaysOnTheTin (a genie)]] and Aladdin (human) in ''Disney/{{Aladdin}}''.
** In ''Disney/TheLionKing'', Zazu (bird) and Mufasa (lion). Also Timon (meerkat) and Pumbaa (warthog), close friends who later befriend Simba. (lion)
** ''Disney/TheFoxAndTheHound''. Between, well, a fox and a hound.
** ''LiloAndStitch'', a human and a genetically engineered alien monster.
** ''BrotherBear'': Kenai (a human turned into a bear) to Koda (a bear cub). Alternatively, two bears and Rutt and Tuke (two moose brothers).
** In ''WesternAnimation/FindingNemo'', not only do different kinds of fish get along, but they also befriend sea turtles, and species that otherwise prey on fish, such as sharks and pelicans.
** ''Disney/TheJungleBook'' has Mowgli the human (who was raised by wolves) befriending Baloo the bear. They also friends with Bagheera the Black [[strike: panther]] leopard.
** ''OliverAndCompany'' has Oliver the cat befriend Fagin's dogs.
** ''TheRescuers'', along with its sequel, involves mice talking to and befriending humans. The first even has a cat talking to and befriending both humans [[ItMakesSenseInContext AND mice]]. The sequel also has Cody feeling very attached to Marahoute the eagle, though they can't communicate with each other.
** ''Disney/{{Bolt}}'' has a trio of three different species: Bolt (a dog), Mittens (a cat) and Rhino (a hamster).
** ''WesternAnimation/ToyStory'': While Andy does not know his toys are alive, they do care a lot about him. Woody in particular gos to great lengths to return to him when separated. Said toys are also TrueCompanions with each other.
** The title character of ''Disney/{{Tarzan}}'' is friends with a gorilla and an elephant.
** ''WesternAnimation/ABugsLife'' has several different insects and arthropods as friends.
** In ''Disney/{{Mulan}}'' Mushu the dragon is friends with Mulan (human), Crikee (cricket) and Khan (horse). Villain Shan Yu has his falcon.
* In ''WesternAnimation/AnAmericanTail'', Fievel Mousekewitz ([[CaptainObvious mouse]]) makes friends with Tiger (cat). They even have [[http://www.youtube.com/watch?v=dQeBcnNQys0 a song together]].
* In ''TheLandBeforeTime,'' a long-neck ([[YouKeepUsingThatWord "Brontosaurus"]]), three-horn (Triceratops), swimmer (Saurolophus), flier (Pteranodon) and spike-tail (Stegosaurus) overcome their parents' generations-long [[FantasticRacism racism]] and become TrueCompanions. A sequel adds a sharp-tooth (TyrannosaurusRex) to the gang and the TV series adds a Oviraptor.
* ''IceAge'': Manny and Diego and Sid form one of this type of friendship with each other by the end of the first film and it continues into the second film and third film. (The unusual nature of this "herd" is duly lampshaded.)
* Shrek, [[OurOgresAreHungrier (an ogre)]] Donkey and eventually Literature/PussInBoots become friends in the ''{{Shrek}}'' films.
* The wolf-dog ''WesternAnimation/{{Balto}}'' is friends with a Russian goose and two polar bears.
* The title character of ''[[WesternAnimation/SpiritStallionOfTheCimarron Spirit]]'' (a horse) appears to be friends with an unnamed bald eagle and he later befriends a human.
* Hiccup and [[OurDragonsAreDifferent Toothless]] in ''WesternAnimation/HowToTrainYourDragon''.
[[/folder]]

[[folder:Films -- Live-Action]]
* ''{{Blade}}'' ({{Dhampyr}}) and Whistler (human)
* ''Film/{{Dragonheart}}'' features the friendship of a man and a dragon.
* The original ''StarWars'' trilogy had Han Solo and Chewbacca, the Wookie, as friends and partners.
* As with the books, in ''Film/TheHobbit'', a friendship was struck up between Bilbo (a hobbit) and Gandalf (disguised as more or less human), not to mention Bilbo's friendship with the dwarves.
** In ''Film/LordOfTheRings'', the Fellowship is composed of hobbits, men, an elf, a dwarf and a Maia. There was already a strong friendship between Aragorn (a human) and Legolas (an elf) and one would develop between Legolas and Gimli (a dwarf).
** Merry and Éowyn, and Pippin and Faramir, hobbits and humans respectively, also become quite close.
* Being a FriendToAllLivingThings that she was, Giselle from ''{{Enchanted}}'' was close to all her animal friends, particularly Pip the chipmunk.
* It takes most of the film but one develops between Kirk (human) and Spock (half-Vulcan, half human) in ''Film/StarTrek''.
** Also, Scotty and Keenser. A human and a... [[BuffySpeak cute alien thing]]...
* Sam and Bumblebee in ''Film/{{Transformers}}'', as well as Captain Lennox and the rest of NEST with the other Autobots.
* Kevin Flynn and the program ''{{TRON}}''.
* In ''[[{{District9}} District 9]]'', Wikus and Christopher, a human [[spoiler:(in the beginning, at least)]] and an alien respectively.
* Any relationship with Thor in ''MarvelCinematicUniverse''.
[[/folder]]

[[folder:Literature]]
* ''Literature/TheJungleBook'', ''The Second Jungle Book'', and the ''Just So Stories'' by Creator/RudyardKipling are full of friendships between humans and animals - Mowgli, the adopted wolf and friend of Baloo the bear, Bagheera the panther, and Kaa the python is only one example of many - and between different species of animals.
* ''Literature/WinnieThePooh'': Features a human boy and his friends, who are [[strike:toys]] a bear, pig, tiger, rabbit, donkey, owl, and two kangaroos. The animated series adds a gopher.
* The Literature/{{Twilight}} books and films, which feature friendships and [[InterspeciesRomance romance]] between humans and vampires, werewolves (technically shape shifters) and humans, and friendships between werewolves and vampires.
* In the book FireWorld, Rosa (A human) and Alleron (A Firebird) are friends.
* In ''Literature/TheLordOfTheRings'', the Fellowship consists of representatives of five species and races (Elves, Humans, Dwarves and Hobbits, plus Gandalf the Maia). Hobbits Pippin and Merry also later become friends with the Ent Fangorn, while Gandalf numbers Gwaihir the Wind-Lord (an intelligent eagle) among his friends.
* A number of examples from the ''Literature/{{Discworld}}'' novels, notably in the Ankh-Morpork Night Watch, starting with Detritus the Troll, Cuddy the Dwarf, and Angua the Werewolf in ''Men at Arms''.
* ''Literature/GoodOmens'' has Aziraphale (an angel) and Crowley (a demon).
* ''Literature/TheBookOfNightWithMoon'' has Arhu (a cat) and Ith (a t-rex).
* ''Literature/DragonridersOfPern'' in which humans form lifelong bonds with intelligent dragons.
* ''Literature/{{Animorphs}}'' has Ax, an Andalite, and the five human characters. Or four human characters and one red-tailed-hawk/human/Andalite (Tobias). The team also count Hork-Bajir and Chee among their friends and allies. Cassie even befriended a Yeerk.
* The core premise of {{Literature/Dinotopia}} is human/saurian friendship. And human/prehistoric mammal friendship, and etc. When they're close enough, they are called "nestfriends", bringing to mind a common sight in the books: babies and children of different species being raised together, sometimes literally with time spent in nests.
* ''Literature/IfYouGiveAMouseACookie'' has a friendship between the eponymous mouse and the nameless protagonist.
* Literature/HarryPotter is friends with Dobby, a house-elf, which is considered odd because most wizards treat them as [[FantasticRacism inferior slaves]]. Before him, [[spoiler: Regulus Black had a similar relationship with his house-elf Kreacher]].
** Harry, Hermione, Ron and a fairly large number of the Hogwarts staff are also friends with [[spoiler: Hagrid, a half-giant. The slightly strained relationship with Hagrid's full giant brother might fit this trope better, though]].
** Depending on whether or not you count [[OurWerewolvesAreDifferent werewolves]] as a [[FantasticRacism different species]], all of Remus Lupin's friendships could count as this.
* ''Literature/TheHorseAndHisBoy'', about the friendship between...[[CaptainObvious well...]]
* Lyra Belaqua (human) in ''Literature/HisDarkMaterials'' becomes close friends with Iorek Byrnison and Serafina Pekkala, an armoured polar bear and a witch respectively.
* In the ''[[Literature/InheritanceCycle Inheritance]]'' quadrilogy you have riders and their dragons. You also have friendships between humans, dragons (outside their riders), elves, dwarves and werecats. Eragon (a human) in particular has several friends from other races, including Arya (an elf), Orik (dwarf) and Solembum (a werecat).
* The ''Literature/MalazanBookOfTheFallen'' includes quite a bit of this. Sometimes it's odd, others times it's not.
* In ''Literature/{{Temeraire}}'' the bonds between dragons and their captains probably go beyond even friendship. However, even if you're not that dragon's captain, close friendships exist. One of the things that marks the Aviators apart from everybody else is that they see dragons as equals, while practically everyone else think they're just talking beasts of burden.
* The ''Literature/ArtemisFowl'' series contains quite a lot of this, especially between human Artemis Fowl and high-tech fairy Holly Short.
* The Second-Stage Lensmen of E.E. "Doc" Smith's ''{{Literature/Lensmen}}'' series are all good friends: Kinnison of Tellus (human), Worsel of Velentia ([[OurDragonsAreDifferent Dragon]] with multiple eyes on stalks, multiple hands and arms, and a multi-compartment mind), Tregonsee of Rigel IV (Oil-drum body with four legs, four branching tentacle-arms, and no eyes or ears - uses a "sense of perception" instead), and Nadrick of Palain VII (Whose appearance cannot be described because his species has a metabolic extension into the fourth dimension). And it's hinted that these sorts of friendships are not all that unusual among Lensmen or in the Galactic Patrol in general.
* In ''Literature/DonQuixote'', it is mentioned that Don Quixote's horse Rocinante and Sancho's donkey Dapple develop a close bond of friendship throughout their adventures.
[[/folder]]

[[folder:Live-Action TV]]
* In ''{{Smallville}}'', any friendship involving [[HumanAlien Clark]], obviously.
* Dean (a human) and Castiel (an angel) in ''Series/{{Supernatural}}''. Also, Dean's brother Sam and Castiel after they grow closer over the seasons (although, to quote Castiel, he and Dean do share a more profound bond…)
** Sam, as a child, became friends with Amelia, a kitsune who saved Sam's life. Dean, however, saw her as a threat [[spoiler: and ultimately kills her (right in front of her son, no less) in season 7,]] an incident that starts creating a breach in the brother's relationship. Ironically, Sam was meant to accept anyway Dean's friendship with Benny (a vampire who helped Dean get out of Purgatory), to which Sam responds by pointing out the hypocrecy of it all after Dean's actions towards Amelia.
* In ''Series/DoctorWho'', all of the Doctor's companions aside from his granddaughter Susan, as well as Romana, fall under this.
* It's hard to imagine ''Franchise/StarTrek'' without this.
* In ''Series/BabylonFive'', there's a particularly [[OddFriendship odd]] one is between Londo (Centauri) and G'kar (Narn), who are the ambassadors of two warring species--one of which (the Centauri) had previously conquered and enslaved the other--and started out hating each other. [[FireForgedFriends Circumstances force them to tolerate and eventually like each other]], if a bit [[VitriolicBestBuds snarkily]].
* ''Series/BuffyTheVampireSlayer'' and the spin-off ''Series/{{Angel}}'' had several frienships between humans, vampires, werewolves, and demons.
* ''{{Lexx}}'' had a human, [[HalfHumanHybrid a half-human lizard girl]], an undead assassin, a robot head, and a living spaceship.
* ''Series/{{Farscape}}'' had a human, HumanAliens, and StarfishAliens.
* ''Series/StargateSG1'' - the Stargate team (humans) with Teal'c (a Jaffa).
** As the series progresses, it also becomes evident that Thor ''really likes'' SG-1, particularly O'Neill. They even named the first of their new line of Starships "The O'Neill". They had to blow it up 5 minutes later, but the thought was there.
* Series/{{Tracker}} Mel and Cole-Although Mel is a HalfHumanHybrid, that only came out in the next to last ep of the series, so it was viewed as human and alien for most of it.
* The ''Franchise/PlanetOfTheApes'' series had two humans (Virdon and Burke) and an ape (Galen).
* ''Series/{{Roswell}}'', with its human and alien teens.
* In ''{{Grimm}}'', Nick (a human/Grimm) and Monroe (a Wesen/Blutbad).
* ''Series/TeenWolf'': Stiles and Scott remain best friends despite the latter being turned into a werewolf in the pilot episode. Also, Scott's girlfriend Allison Argent, who's human, and Lydia Martin, [[spoiler: a banshee.]]
** Kali and [[spoiler: Jennifer ]] were pretty close in the past despite belonging to different species (the former a werewolf, the latter a druid), although they were torn apart when Kali massacred her entire pack to become an Alpha and join Deucalion, marking the druid's StartOfDarkness.
[[/folder]]

[[folder:Video Games]]
* ''Franchise/TheLegendOfZelda'':
** ''VideoGame/TheLegendOfZeldaOcarinaOfTime'' had the friendship between Saria (a Kokiri) and Link (a Hylian/Human), sans ShipTease. He was also friends with Navi, a fairy. The plot of [[VideoGame/TheLegendOfZeldaMajorasMask its sequel]] starts with him trying to find Navi after she left him.
** ''VideoGame/TheLegendOfZeldaTwilightPrincess'' has Link growing a friendship with [[TheImp the imp-like]] Midna, a Twili. This one also comes with some good ammounts of ShipTease.
* Early in ''VideoGame/SuikodenII'', the player is given the opportunity to recruit Kinnison and his dog companion (who's actually a wolf), named Shiro.
* Yuri Lowell and Repede from ''VideoGame/TalesOfVesperia''. Bonus points since Repede earns two titles specifically regarding his friendship with Yuri:
** "Sinful Sidekick", which is earned after [[spoiler: he witnesses Ragoh's death at Yuri's hands.]]
** "Considerate Sidekick", earned after [[spoiler: he leads Karol and the others to Yuri, for trying to strike off on his own]].
* Pretty much all of ''Franchise/SonicTheHedgehog's'' friendships fall into this. For example, there's his long-timed friendship between him, a blue hedgehog that can run at mach speeds, and Miles "Tails" Prower, a twin tailed fox... who can fly.
* ''Franchise/MassEffect'', where [[PlayerCharacter Commander Shepard]] can develop close, non-romantic friendships with several different kinds of aliens, and, of course, develop {{Interspecies Romance}}s as well. Not to mention the ones between [=NCPs=].
* In ''VideoGame/DragonAgeOrigins'', no matter your race, you can befriend elves, dwarves, humans, and [[OurOrcsAreDifferent Qunari]].
* ''Franchise/{{Metroid}}''
** In ''VideoGame/SuperMetroid'', Samus can befriend creatures who teach her to WallJump and use the speed booster. They survive [[EarthShatteringKaboom through the ending]], and show up again in ''VideoGame/MetroidFusion''.
** In ''VideoGame/MetroidPrime 3'' Samus can count among her friends Rundas, a [[AnIcePerson Phyrigisian]] and [[{{Shapeshifting}} Gandrayda]], whose species is unknown, though Gandrayda seems to love piling on the LesYay.
* ''Franchise/SuperMarioBros''
** Considering humans, dinosaurs, mushrooms, [[LoadsAndLoadsOfRaces and what not]] live all in the same kingdom it's only natural this'd show up. For a specific example, Mario and Yoshi are best friends.
** The ''VideoGame/PaperMario'' series is even more obvious about this, with its focus on storyline and the huge ammount of partners Mario has, many of them being friendly versions of {{Mook}} especies like Goombas, Koopas, Lakitus, Boos, and many others.
* ''VideoGame/{{Okami}}'' has Amaterasu, a sun goddess in wolf form, and Issun, a [[{{Lilliputians}} Poncle.]]
* The entire Creator/NipponIchi verse is full of these, since regular humans live side by side with angels, demons, robots, aliens, talking animals, and bipeds with animal aspects. For example: Flonne with Laharl and Etna in 'VideoGame/DisgaeaHourOfDarkness''.
* ''Franchise/{{Pokemon}}''
** An important {{Aesop}} in all of the games, but especially ''VideoGame/PokemonGoldAndSilver'' and the remakes, is that Pokémon should be friends and partners to their trainers, instead of just tools.
** The ''VideoGame/PokemonMysteryDungeon'' series has the PlayerCharacter and their partner. Not only are both different especies of Pokémon, but the PlayerCharacter is also a human turned Pokémon by some circumstance.
* In ''VideoGame/BlazBlue'', we have the trio of Noel Vermillion, Tsubaki Yayoi (two humans) and Makoto Nanaya (squirrel girl). This has such a great effect that the formerly prejudiced-for-her-race Makoto is incredibly loyal to those two and makes it her mission to ensure no harms come between them, and anyone who does get horribly killed by her hands (Or so she says for the latter), and the mere thought of her friendship to them is the one thing that enables her to survive the Boundary like Hakumen, and be immune to Terumi's infamous {{Troll}}ing. [[spoiler: Unfortunately, while getting [[MindRape mind raped]] in her bad ending, it's revealed that deep down, Makoto doesn't trust Noel and Tsubaki either, and she's just waiting for them to reject her like everyone else. We'll see if this comes into play in future games.]]
* The vast majority of ''VideoGame/{{Kirby}}'s'' friendships are of the interspecies variety, due to living in a world inhabited by many different sapient species but very few of his own kind.
* ''VideoGame/{{Xenoblade}}'' has several examples of this all around the world. Amongst the main party, both Riki (a Nopon) and Melia (a High Entia) have a good friendship, and also develop some close bonds with their [[HumansByAnyOtherName Homs]] partners as the game goes on; in one case even growing into unrequited InterspeciesRomance.
* ''KingdomHearts'': Most notably, Sora's friendship with Donald and Goofy.
[[/folder]]

[[folder:Webcomics]]
* Pretty much every FurryComic ever.
* Florence ({{Uplifted|Animal}} wolf) and Sam ([[StarfishAlien Alien Sqid]]) in ''Webcomic/{{Freefall}}''.
* ''TheInexplicableAdventuresOfBob:'' Bob is friends with [[DragonsAreDinosaurs dragons,]] [[{{Unicorn}} unicorns,]] [[BigfootSasquatchAndYeti bigfeet,]] [[AlienTropes aliens,]] [[RobotBuddy robots,]] [[StockNessMonster mutants,]] [[OurGiantsAreBigger giants,]] and [[CuteMonsterGirl furry lab accidents.]]
* ''Webcomic/TheMansionOfE'' has the repair-team of Sprocket and Flange (Gnoll and Helipath), and the idlers Tuft and Dap (Gobule and Gnoll).
* In ''OffWhite:'' [[{{Hellhound}} Hati]] the wolf and the two ravens. One raven even [[spoiler: sacrifices himself for Hati.]]
* ''Webcomic/{{Digger}}'' and... everybody, really, since she's the only (living) wombat in the cast, but especially her relationship to the [[{{Unperson}} nameless]] hyena she calls "Ed".
* In ''Webcomic/{{Homestuck}}'', between the kids, carapacians, and some of the trolls. The post-scratch kids and Calliope are also friends, though Calliope's abusive brother makes it strained at times.
[[/folder]]

[[folder: Web Original]]
* ''Website/ChatoyantCollege'': Corrie/Dawn and [[spoiler: Professor Lal]], the gang and [[spoiler: Troy]], and [[spoiler: Dawn and Tom]]
* ''WebAnimation/RatboyGenius'' has Happyman and Green Monster. [[ExactlyWhatItSaysOnTheTin Happyman appears to be human and Green Monster is a ... Monster. Who is green.]]
* In ''WebOriginal/AfterlifeLabirynth'', Wryg the bred (male, Polish ''bred Wryg'') and Waom the wohu (female, Polish ''uowujka Uaom'') are [[TheProtagonist Joseph]]'s friends.
[[/folder]]

[[folder:Western Animation]]
* ''WesternAnimation/AdventuresFromTheBookOfVirtues'' has two human kids, a bison, a red-tailed hawk, a bobcat, and a prairie dog.
* ''WesternAnimation/AvatarTheLastAirbender'' also has this with Aang and his sky bison, Appa. Later, he befriends Momo (his pet Lemu) as well; which isn't surprising since Aang's a FriendToAllLivingThings.
* Ben10Omniverse has Ben with Rook, a Revonnahgander.
* In ''WesternAnimation/{{Futurama}}'' there is Bender and Fry, and to a lesser extent the other members of the Planet Express crew. Also Zoidberg.
* ''GeorgeOfTheJungle'' comes to mind.
* In ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' the unicorn Twilight Sparkle is friends with her assistant Spike, a baby dragon. [[FriendToAllLivingThings Fluttershy]] is friendly with most non-pony animals and beasts (which seem to be more intelligent than real-world animals), and goes on to become the first friend [[MadGod Discord]] has ever had and [[ReformedButNotTamed reform him to boot]]. Pony characters have also developed friendships with buffaloes, zebras and gryphons (all of which are sapient species equal to ponies).
** In the [[WesternAnimation/MyLittlePonyEquestriaGirls movie]], Twilight Sparkle makes friends with the human counterparts of her friends in an AlternateUniverse. Her friendship with Flash Sentry even gets ''this'' close to being an InterspeciesRomance.
* Pretty much any human friendship in ''{{Transformers}}'':
** Starting it was Spike, his father Sparkplug and Carly in ''[[TransformersGeneration1 Transformers G1]]''.
** In ''TransformersAnimated'', there was Sari.
*** Sari doesn't really count, she's [[spoiler: half Cybertronian]].
** ''WesternAnimation/TransformersPrime'' has Jack, Miko and Raf.
* ''WesternAnimation/AdventureTime'' has the two main characters, Jake the dog and Finn the human. There's also Marceline the Vampire Queen and Princess Bubblegum (the anthropomorphic candy). Really though, almost every relationship in the land of Ooo could count as this on account of the world being made up almost entirely of anthropomorphic everything (animals, food, land etc).
[[/folder]]

[[folder:Real Life]]
* They say a man's best friend is his dog. Cats, birds and horses are also common companions.
** Really, just about any solid pet/owner friendship. Most domesticated animals quite enjoy human company.
* Koko the gorilla used to have a pet kitten.
* [[http://www.msnbc.msn.com/id/10903211/ns/world_news-weird_news/t/hamster-snake-best-friends-tokyo-zoo/#.Tzw8eVHC5v8 This news story]] tells of Gohan and Aochan - a dwarf hamster and rat snake, respectively - who peacefully share an enclosure at a zoo in Japan (or ''shared,'' most likely, due to the average lifespan of hamsters and the article being written in 2006). [[MeaningfulName Gohan]] was intended to be Aochan's lunch when the snake refused to eat frozen rodents, but Aochan never showed any hostility, eventually taking to frozen food. They got along so well that Gohan could safely climb onto the snake's back to take naps.
* The French racehorse Allez France shared its box with a sheep.
* [[http://youtu.be/0czs_OtqrLA An old man named Dominic and a goose]] known by locals as "[[http://en.wikipedia.org/wiki/Maria_(goose) Maria]]"[[note]]now known as "Mario" after [[UnsettlingGenderReveal they discovered that the goose was in fact a male]][[/note]] from Echo Park suddenly started following him and has been doing so ever since. The goose would even scare away people and other animals whenever they get anywhere near the old man.
* There is a show on the channel AnimalPlanet called UnlikelyAnimalFriends that has many examples of this trope. Warthog and baby rhino, boar and cows, baboon and bush baby, etc.
** Also happens a lot on ''Series/TooCute'', particularly between kittens and dogs.
* It turns out that goats and horses make very good friends. This is actually where the term "Getting your goat" came from: owners of racing horses would give them goats as stable companions, and sometimes before a race someone would kidnap the goat to make the horse perform poorly.
* This [[https://www.youtube.com/watch?v=vL8x7LcA-Y4 grizzly bear and wolf cub]], even after six year they were still together!
** It seems it's not just grizzlies, [[http://channel.nationalgeographic.com/wild/unlikely-animal-friends/videos/polar-bears-heart-wolf-dogs/?cmp=user_post polar bears and wolves]] also make fast friends.
* At Noah's Ark animal sanctuary in Georgia, an African lion, a Bengal tiger, and an American black bear all share the same enclosure. The three were rescued from a drug dealer's house as cubs, and they have lived together as the best of friends for over a decade, even acting out and getting distressed when sanctuary personnel tried to split them up. What makes the arrangement even more unusual is that black bears and Bengal tigers in the wild are solitary creatures who rarely associate even with their own kind.
[[/folder]]

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