->''"A mouse in the wainscotting! Well squeaked, mouse!"''
-->-- '''The Doctor''', ''Series/DoctorWho'', ''The Robots of Death''

Because helium is lighter than air, when you inhale it and try to talk it causes the vocal cords to vibrate at a higher frequency, resulting in reedy, duck-like voices that can be used to great comic effect. This can be tried in real life, although it should be noted that helium displaces oxygen in your lungs, so breathing it too long can be harmful.

Gasses that are heavier than air, such as sulfur hexafluoride and xenon, have the opposite effect, resulting in a temporarily evil- or gruff-sounding voice, but this rarely appears in fiction probably because the gas is less widely known. They're also a lot more dangerous; for obvious reasons, it's easier for a heavier-than-air gas to build up in your lungs than a lighter-than-air gas. Unless you're standing on your head.

Because it is easy, plausible in many settings, and can be very funny, helium voice often shows up in fiction.

It should be noted that contrary to popular belief, helium actually changes the ''timbre'' (as in the quality) of one's voice, not the pitch. Regardless, those who favor the easy and cheap way of getting things done or just didn't do the research still go for artificially pitch-shifting the characters' voice in spite of this tidbit.

InstantSoprano is a more-painful way to induce higher-than-normal vocal pitches in fiction.



* [[http://www.youtube.com/watch?v=0Qh8vuXsk5c Used in this his Twix commercial.]]

[[folder:Anime & Manga]]
* An episode of ''Anime/{{Pokemon}}'' involved Team Rocket using the rather smart plan to disrupt the voices of an Officer Jenny and the other Trainers using helium, so their Pokémon wouldn't recognize their commands. Then they used voice changers to imitate the Trainers' usual voices. It fails because the Pokémon are able to tell who their real Trainers are in the end.
* The ''Anime/CowboyBebop'' episode "Waltz For Venus" features an expedition to the titular planet, whose atmosphere consists largely of helium when the series takes place. Naturally, it has the expected effect on the characters' voices.
* In episode three of ''Anime/WandabaStyle'', TheProfessor's latest experiment involves [[GirlGroup the girls of MixJuice]] and [[RobotGirl Satellite Girl]] Kiku#8 taking a blimp filled with experimental helium into the stratosphere. On the way up, they end up losing most of their air supply, and Kiku replaces it with "extra" air. Unbeknownst to any of them, the air was actually some of the helium, which they find out when [[ItMakesSenseInContext they're giving a concert]].
* Fat Buu talks like this in the English dub of ''Anime/DragonBallZ'', when in the Japanese he sounds more like a jovial old man.

* In the Creator/RobinWilliams stand-up routine ''Weapons of Self Destruction'', he states that this is the reason why we need to invent cars that run on helium. Because there would be nothing funnier than two angry guys getting out of the car after a wreck and having them going "I'm gonna kick your ass... Crap, I think one of us has a gas leak."
* An old short bit on ''The Dr. Demento Show'' ran like this:
-->'''Man:''' Well, first it was, y'know, just a social thing....\\
'''Interviewer:''' Right, mmm-hmm....\\
'''Man:''' ....then I found myself hangin' around supermarket openings, and kids' birthday parties, y'know, anywhere there was balloons.\\
'''Announcer:''' This man has a problem.\\
'''Man:''' And now it's every couple of hours. (''Sound of balloon deflating, breathing in'') (''In helium voice'') Here, y'wanna hit?\\
'''Announcer:''' This man is hooked on helium. Today, one in every two hundred million Americans is a habitual helium head. It may begin with a single heart-shaped balloon, but just a few birthday parties later -- this could be you:\\
'''Man:''' I think, uh, I realized I was in trouble on Thanksgiving Day.\\
'''Interviewer:''' What happened then?\\
'''Man:''' I was at the Macy's Day Parade, and, uh, I must've blacked out or something, I don't know... next thing I know, I was a hundred feet in the air, and.... (''Sound of balloon deflating, breathing in'') (''In helium voice'') ...I was sucking Snoopy's tail.\\
'''Announcer:''' Helium. Please....just say, [[{{Pun}} "No, tanks."]] (''Sound of balloon deflating, breathing in'') (''In helium voice'') A message from the National Helium Foundation.

[[folder:Comic Books]]
* During Mark Waid's ''ComicBook/FantasticFour'' run, a shrink-rayed Ben is combing the Baxter Building's air ducts for an alien bug. Reed, talking to him via intercom, keeps cracking up over his "little helium voice" and asks him to say "It's clobberin' time."

[[folder:Comic Strips]]
* In one ''ComicStrip/FoxTrot'' strip, Jason imagines himself floating to the ceiling after inhaling helium, only to express his disappointment (in [[PaintingTheMedium curly letters]]) that it only makes his voice funny.
* On ''ComicStrip/TheFarSide'', some big dogs take turns inhaling helium balloons and barking like small dogs.
* There's a ''Magazine/{{MAD}}'' gag where two men come across a vending machine labeled "A hit of helium - $1.00." The first man takes a hit and then speaks in a squeaky voice (represented by a lot of whitespace in his speech balloon). The second man, having only a quarter, puts his money in a machine labeled "Helium substitute," and a boot comes out to [[GroinAttack kick him in the 'nads]], having [[InstantSoprano a similar effect on his voice]].

[[folder:Fan Works]]
* [[http://mrmenoc.wikia.com/wiki/Little_Miss_Light_(MrMenCentral) Little Miss Light]], a Literature/MrMen fan character. Bonus points for her being shaped like a balloon.

[[folder:Films -- Animation]]
* Used to get the voices of the WesternAnimation/ToyStory Martians, rather than artificially speeding up the voices.
* In ''WesternAnimation/{{Up}}'', Alpha's malfunctioning collar makes him talk like this. The collar's normal voice is deep and menacing, of course.
* In ''WesternAnimation/IceAge3DawnOfTheDinosaurs'', "deadly gas" turns out to be helium which, as mentioned before, can become deadly after extended periods. The characters' discovery leads to an Franchise/AlvinAndTheChipmunks impersonation and HilarityEnsues. It is later explained that the deaths were because the victims died laughing.

[[folder:Films -- Live-Action]]
* ''Film/PoliceAcademy4CitizensOnPatrol'' has characters switching helium and oxygen bottles to play a trick on Captain Harris.
* ''Film/MyBestFriendsWedding''
* Robin Williams has this in ''Film/ClubParadise'' when he went diving and found out that he bought helium tanks instead of oxygen.
* The Martians in ''Film/MarsAttacks'' [[spoiler:get the same effect from huffing a nuclear explosion. It even makes sense if it was a fusion bomb, since they work by fusioning hydrogen to, well, helium]].
* In ''Film/HotShotsPartDeux!'' the President of the United States, played by Lloyd Bridges questions while diving why he brought helium instead of air - with the voice shift at an appropriate point of the InnerMonologue.
* [[InvertedTrope Turned on its head]] in the first ''Film/AlvinAndTheChipmunks'' movie: there's a scene where Alvin inhales helium, but since his voice is already high-pitched, it becomes low-pitched instead. A definitive ArtisticLicensePhysics moment, even if it ''is'' funny.
* In ''Film/{{Flubber}}'', Robin Williams' character's flubber experiment causes a helium gas tank to leak open and you know what happens after that.
* Film/{{Sneakers}}: Carl does this during a party at the team's HQ, much to the amusement of the other hackers.
* ''Film/BroadwayDannyRose'': Creator/WoodyAllen with a helium voice. Heh heh.
* ''Film/MaxKeeblesBigMove'' had Robe trying to pass the time waiting for Max to arrive for his going away party by blowing up balloons to get the desired effect. As soon as he does get it, he shouts "Yee-haw!" in a very high-pitched voice, and sounds this way for the remainder of the scene.
* In ''Film/DirtyWork'', [[Creator/NormMacDonald Mitch]] sounds like this, after [[ItMakesSenseInContext his father]] [[GroinAttack crushes his balls]].
--> Note to self: Forget about having kids.
* ''Film/WhoFramedRogerRabbit'': The villain does this at the end to unnerve Eddie.
--> "When I killed your brother, I talked...'' ''[[PunctuatedForEmphasis JUST...]][[ExaggeratedTrope LIKE...]][[UpToEleven THIIIIIIIS"]]''
* In ''Film/PlanesTrainsAndAutomobiles'', Neil talks like this after his confrontation with the guy who runs the cab stand:
--> '''Del:''' I've never seen a guy get picked up by his testicles before. Lucky thing for you that cop passed by when he did. Otherwise, you'd be lifting up your schnutz to tie your shoes. I'm sorry. That's terrible. Do you have any idea how glad I am I didn't kill you?
--> '''Neal''' (''in Helium Speech'')''':''' Do you have any idea how glad I'd be if you had?

* In the latest Franchise/StarWarsExpandedUniverse novel (''Literature/FateOfTheJedi: Outcast''), Luke Skywalker's teenage son Ben removes his oxygen mask on a planet with a lot of helium in the atmosphere (Plo Koon's homeworld in fact). He then goes on to sing a song to the annoyance of his father.
** Here's the song:
-->''Where fields once grew, a road runs through, and buildings hide the sun,''
-->''Where grass of green could once be seen, are only gray and brown.''
-->''My childhood home, while I did roam, became a place of sadness.''
-->''Now I return, my heart does yearn for times of light and gladness.''
** A very sad song. [[SoundtrackDissonance Until you imagine it in a helium voice.]]
* ''Literature/TheEyeOfArgon'' is often read aloud this way.
* The title character of ''Literature/StepsisterFromPlanetWeird'' is from a shapeshifting alien race that lives off helium. When her Earthling stepsister walks in on her sucking the helium from a party balloon as a snack, the alien tries to explain herself and is surprised that her human form suddenly has a high, squeaky voice.
* In ''Judgement at Proteus'', the fifth Literature/QuadrailSeries book, Frank Compton uses this to [[spoiler:disrupt the Shonkla-raa's ability to control the Modhri through a special hummed tone]]. This may have been inspired by the ''Series/DoctorWho'' example above.
* In James Blaylock's ''Homunculus'', the oxygenator device spews out blasts of helium and chlorophyll whenever it's activated. Willis Pule mistakes it for another Macguffin and steals it, only to be hit in the face by one of these blasts when he tries to open it, freaking out when he hears his own altered voice.

[[folder:Live-Action TV]]
* In ''Series/{{Farscape}}'', Rygel will, if nervous or angry, [[BizarreAlienBiology fart helium]]. Anyone in close proximity to him will start speaking in a high-pitched voice.
* ''Series/MythBusters'' not only does this during experiments where helium is involved, but they've also used Sulfur Hexafluoride, a gas six times denser than air to get the opposite effect, with a "Don't try this at home!" warning from Adam right before he starts inhaling the stuff ("And my voice gets really low, although somehow I'm still funny. It's scientific! [[EvilLaugh HAHAHAHAHA!]]") Watch it [[http://www.youtube.com/watch?v=d-XbjFn3aqE here]].
** And while it did make his voice almost demonic in how deep it sounded, it would later be revealed that the Sulfur Hexafluoride displaces the gas in the lungs required to - you know, ''breathe'' - and that a potential side effect of breathing it in could very well be ''death.'' Of course, the same can be said for helium. Either way, DontTryThisAtHome.
* Parodied in ''Series/WillAndGrace'', a character with a high pitched voice doesn't sound any different.
* One episode of ''Series/{{Friends}}'' has Chandler inhaling helium and singing "I Will Survive".
* ''Series/DoctorWho'' uses this for a non-comedic purpose in ''The Robots of Death''. After the villain controlling the robots orders them to kill the humans (except himself), the Doctor gets Leela to open a cylinder of helium so that robots won't recognise the villain's voice and kill him. The Doctor is unaffected by the helium though, due to his BizarreAlienBiology.
* On ''Genius'', Dave Gorman and guest Neil Innes couldn't resist giving this a try when someone suggested Helium-filled bubble wrap.
* ''Series/TheDayToday'' uses the trope to [[http://www.youtube.com/watch?v=w6UhXivPyw4 particularly hilarious effect]] in a report on Sinn Fein. In a case of ArtImitatesLife, ''The Day Today'' mastermind Chris Morris, as a junior in radio, released helium into Creator/TheBBC's air vents just as the news was about to be broadcast.
* Once on ''Series/ThePriceIsRight'', announcer Rich Fields inhaled helium before reading the prize copy as part of a Showcase skit. He then did it again for his signoff.
* There was also an episode of ''Series/WheelOfFortune'' where, on a set decorated with balloons, neither Pat Sajak nor Vanna White could resist.
* ''Series/TheBigBangTheory'':
** In the episode "The Vengeance Formulation", when Sheldon appears on the National Public Radio talk show Science Friday, his enemy, Barry Kripke, fills his office with helium.
** In the episode "The Launch Acceleration", Leonard shows Penny how the sulfur hexafluoride he uses in his experiments causes deep voices.
* One death in ''Series/OneThousandWaysToDie'' (#226, to be exact) involved a teenage couple breaking into a large helium-filled basketball due to this trope. By the time they realized they couldn't breathe, they were in no state to find the seam again.
** Presumably based on this [[http://darwinawards.com/darwin/darwin2006-05.html 2006 Darwin Awards story.]]
* Wayne Brady of ''Series/WhoseLineIsItAnyway'' was known for pulling this off ''without actual helium.''
* An episode of ''Series/HannahMontana'' had Miley and Jackson throw a makeshift party for Robbie Ray and invite a few people, one of whom is the guy who blows up the balloons.
* The ''Series/{{Eureka}}'' episode "What Goes Around Comes Around" has a particle accelerator that's cooled by liquid helium. Naturally the cooling line breaks and everyone becomes squeaky for about half a scene until they can shut the line off.
-->'''Carter:''' Why are we talking like Chip N' Dale?
* ''Series/TopGear'' once tested how well the roofs of old convertibles had held up by putting the presenter in their vehicle with an open tank of helium. [[https://www.youtube.com/watch?v=-zcBMVkVT4I James and Jeremy's]] roofs were in good condition and held in the helium, resulting in them getting squeaky voices. Richard's [[TheAllegedCar heavily-modded]] convertible allowed the helium to leak and didn't change his voice at all, much to his disappointment.
* In ''Series/MyNameIsEarl'':
-->'''Randy''': ''(inhales balloon air)'' ''(in helium speech)'' [[Film/TheWizardofOz We represent the lollipop guild, the lollipop guild, the lollipop]]--
-->'''Darnell''': Randy, those aren't helium balloons.
-->'''Randy''': ''(Normal voice)'' Aw, too bad.
* On ''Series/{{Cheers}}'', Norm and Cliff sing "Lollipop" this way at Rebecca's bridal shower until Frasier stops them.
* On her talk show, Ellen [=DeGeneres=] decided to put deep-voiced ''Series/AmericanIdol'' winner Scotty [=McCreery=] to the test. The [[https://www.youtube.com/watch?v=SY0we-OJS0c results]], or lack thereof, were amusing.
* In one episode of ''Series/LateNight with Creator/DavidLetterman'' where the theme of the night was audience voting, the audience voted to have Dave's and his guest's voices [[http://www.youtube.com/watch?v=f4Z4dyVANA8 electronically modified to sound as if they had inhaled helium.]] Dave's guest (Jane Pauley) refused to talk after that
* In an episode of ''Series/TheAdventuresOfBriscoCountyJr'' Brisco and several of his companions board a blimp created by Professor Wickwire. The blimp uses helium, and the trope is invoked.
* In a [[http://www.youtube.com/watch?v=9SwQtVsRXsc scene]] from Series/{{Scrubs}}, J.D. talks about a nervous patient who accidentally inhaled air from a helium tank.
* One episode of ''Series/HellsKitchen'' had Sabrina and Tek messing around with helium while blowing up balloons for a dinner party, even going so far as to imitate Ramsay.
* In one episode of ''Series/SpecialUnit2'' they found the Pied Piper of Hamlin (or at least one of his species) acting as a kid's show host and using his music to make the viewers commit crimes. The agency determined that they needed to alter his instrument so it dropped half an octave to break his control, then discovered that the instrument was fake and that the music was his own voice, so Nick shot a few nearby balloons while he was playing.
* The Spanish GameShow ''Series/ElGranJuegoDeLaOca'' (The Great Game of the Goose) had this as one of the challenges. The contestant was blindfolded and had to [[https://www.youtube.com/watch?v=O8ppdkkIAyA guess the voices]] of the show's hosts and characters after they sucked helium from a machine.
* [[https://www.youtube.com/watch?v=qhYaYuc0WJE The Helium Chorale]]. Scottish comedy Duo Hale&Pace slaughter Händels "Halleluja". Cue instant loss of dignity.
* ''{{Series/Scorpion}}'': In "Dam Breakthrough", the team needs helium balloons. Toby inhales from a tank and starts singing "Grandma Got Run Over by a Reindeer". Cabe, looking incredibly serious, also inhales some and continues singing. Happy breathes some in and finishes the verse, culminating in a rare slight giggle from her.
* ''Series/{{CSI}}'': In "The Finger", a kidnapper inhales helium capsules to disguise their voice when making ransom demands.

* Music/{{Ween}}'s ''Push Th' Little Daisies'' is popularly but erroneously believed to invoke this trope. Also overlaps with LyricalDissonance.

[[folder:Video Games]]
* Rayman uses this practically in the opening of ''Rayman VideoGame/RavingRabbids 2''. You'll see.
* Guybrush in ''VideoGame/MonkeyIsland2LeChucksRevenge'', shown through giving his dialogue lines a tiny font (the remake of the game has voice acting, so you get to hear it). Also used in ''VideoGame/TheCurseOfMonkeyIsland'', which had voice acting as well.
* Helium is an important element of several puzzles in one of the ''SamAndMax'' games, since it lets Sam sing high notes. Badly.
* The Science Vessel in ''Franchise/StarCraft'' has this as one of their StopPokingMe sounds:
-->I think we may have ''(shift)'' gas leak.
* In ''VideoGame/ConkersBadFurDay'', if you use the first ContextSensitiveButton for a second time after Conker's hangover is healed, he'll pull out a helium canister, which Birdy will snatch and huff (as if he was drinking a beer, actually):
-->Really nice helium, heheheh.
* In ''TheSimpsonsGame'' one of Homer's powers is inflating himself in which he'll say random dialogue in helium speech. "I'm slightly lighter than air".
* In ''[[VideoGame/GuiltyGear Guilty Gear Xrd]]'', one of items Faust can throw at random is a bottle of helium that serves no purpose other then giving the one who touches it a comically high pitched voice for a lengthy period of time.
* Miis in ''VideoGame/MarioKart'' have become (in)famous for this.
* In ''VideoGame/Crysis2'', [[GeneralRipper Commander Lockhart's]] [[LargeHam hammy]] exhortations to his men to kill you can be made even more comical via an [[EasterEgg easter egg]] that you can trigger to release helium into his room.

[[folder:Visual Novels]]
* Used in the prologue of ''VisualNovel/{{Ever17}}''. Before visitors can enter the underwater theme park of [=LeMU=], they must go through a compression chamber and adjust to the change in air pressure via helium. Earphones are given to each visitor to make everyone's voices sound normal, but when Takeshi removes them and talks to an already high-pitched Coco...

[[folder:Web Animation]]
* ''WebAnimation/HappyTreeFriends'': Cuddles pulls this in "A to Zoo" with a helium tank for inflating balloons. Of course, it's ''Happy Tree Friends'', so eventually he manages to impale and inflate his eyeball with it, which later traumatizes Flaky.
* ''WebAnimation/HomestarRunner'':
** Played with a bit in the [[http://www.homestarrunner.com/sbemail38.html appropriately named SBEmail]]. Strong Mad tries to do this, but it has no effect on him:
--->'''Strong Mad:''' (''usual guttural half-shout'') THIS IS MY FUNNY VOICE! (''speaks louder for emphasis'') ''THIS IS MY FUNNY '''VOICE!!!!'''''
** However, we later find that sucking up ''bandwidth'' has this effect on Strong Mad. Don't ask.

[[folder:Web Original]]
* In the ''WebVideo/BadCallTV'' episode "[[http://www.youtube.com/watch?v=fVasBa2jgXs You Got the Flight Stuff, Baby,]]" one man winds up with this voice after consuming enough Pepsi to gain the ''Seven Million Pepsi Points'' required for a Harrier Jump Jet that was (jokingly) mentioned in the commercial. Sadly, this is only [[http://en.wikipedia.org/wiki/Leonard_v._Pepsico,_Inc partly fictional]]. No, one man didn't actually drink ''that much'' Pepsi, but he did manage to convince enough people to give him their Pepsi Points to try for the plane.
* A young couple earned a mention on the Website/DarwinAwards web archive, having remained inside a large helium-filled (and oxygen-deficient) inflatable chamber, laughing about their own altered voices, long enough to pass out and die.
* Daniel Floyd of ''WebAnimation/ExtraCredits'' constantly narrates his videos with a voice that sounds like it's been computer-shifted into this.
* In the MusicalEpisode of ''Series/FlandersCompany'', Armand Trueman breathes in a helium balloon so he can sing with a high-pitched voice.

[[folder:Western Animation]]
* Happened unintentionally to WesternAnimation/EarthwormJim in the animated series, with Peter Puppy being unable to stop laughing.
* Used in ''WesternAnimation/ClerksTheAnimatedSeries''; Silent Bob inhales helium and stands in silence for several seconds. Jay tells him in exasperation, "It's only funny if you talk, stupid."
* In an episode of ''WesternAnimation/SeaLab2021'' in which a Franchise/{{Predator}} was running around the place killing people, Dr. Quinn had the bright idea to mess around with the station's atmosphere in an attempt to hinder the alien aggressor. This ended up pumping a lot of helium into the air vents, which resulted in the crew laughing uproariously over how one of them sounded like [[Franchise/AlvinAndTheChipmunks a Chipmunk]]... who is then killed by the Predator, [[BlackComedy the crew laughing at his high-pitched screams of agony]].
* A ''WesternAnimation/FamilyGuy'' cutaway shows Stewie doing helium at a birthday party:
-->'''Stewie:''' I'm a female! I have a high voice! I have reproductive organs inside of me, and I buy groceries!
* ''WesternAnimation/TheSimpsons'''s Sideshow Bob, while broadcasting his plan to destroy Springfield from inside the Duff blimp in "Sideshow Bob's Last Gleaming"; Lisa figured out where he was from the squeaky voice, and she and Bart head out for the Duff blimp. After Bob finishes his speech in his chipmunk voice, he says "Pesky helium! Shoo! Shoo!" and waves his hands, and his voice goes back to normal.
* In ''WesternAnimation/HomeMovies'' episode "It Was Supposed to Be Funny," Brendon and Jason take balloons and candy over to Melissa's house, and after she says, "It'll take more than balloons and flowers for me to forgive you, Brendon Small," and upon her departure her dad says to the boys, "Could I have some of that candy?" the three male characters suck in helium on Melissa's dad's couch - the moment highlights that they're all very stuck in boyhood.
* ''WesternAnimation/BatmanTheBraveAndTheBold'': Batman teams up with the Metal Men, a team of periodic element-themed robots, to fight the Gas Gang, a team of slightly-less periodic element-themed animated gas clouds (one of them's named Chloroform) in the episode "Clash of the Metal Men". Helium's [[WhatKindOfLamePowerIsHeartAnyway only power is to give people]] Helium Speech. Luckily for him, he's the kind of guy who thinks [[AngstWhatAngst that gag never gets old]]. Truthfully though, when used on Batman, it's [[TheComicallySerious hilarious]].
* ''WesternAnimation/RobotChicken'' depicts Franchise/AlvinAndTheChipmunks as having fairly deep voices until Dave floods the recording studio with helium in an attempt to asphyxiate them, but [[BlackComedy kills them in the process]].
* In ''WesternAnimation/PhineasAndFerb'', one of Dr. Doofenshmirtz's evil plans involved filling the entire tri-state area with "Doofelium" making his high squeaky voice lower in comparison, because making his own voice lower would be too much of a hassle. Ended up affecting himself and yelling out his {{catchphrase}} [[OncePerEpisode ("Curse you Perry the Platypus!")]] in helium speech.
* Happens once in ''WesternAnimation/FanboyAndChumchum'' when Boog's [[BubbleBoy plastic bubble]] gets filled with helium, right as he's about to punch the titular characters. He notes that it's VERY hard to sound threating with his voice like that.
* ''WesternAnimation/TotalDrama'':
** Noah gets one of these in ''Total Drama World Tour'' after a serious GroinAttack with a golden statue head.
** Harold gets one in the finale after Courtney {{Groin Attack}}s him, hilariously, he does a literal ''speech'' while in Helium Speech mode.
* The ''WesternAnimation/LooneyTunes'' short "Long Haired Hare". Bugs Bunny replaces an opera singer's throat spray with liquid alum; as he does warm up exercises singing Figaro, each time he says it his head shrinks and his voice becomes higher pitched.
* In the ''WesternAnimation/ScrewySquirrel'' cartoon "Lonesome Lenny" at one point Screwy sticks Lenny's head into a bucket of alum and he says while his head is shrinking "Why did you put my head in the bucket George?, you shouldn't have put my head in the bucket George, why did you do it?" in a high pitched voice.
* In an episode of ''WesternAnimation/RocketPower'' Sam accidentally spreads the "Fiji Flu" to his friends where one of the side effects is having a very high pitched voice.
* In an episode of ''WesternAnimation/ClassOf3000'', helium is released into the cooling vents as a practical joke. Those affected included [[CoolTeacher Sunny Bridges]], [[ButtMonkey Kam]], [[BookDumb Li'l D]], and Principal Luna. Notably, it didn't affect [[GeniusDitz Philly Phil]], who thought his voice would sound weird.
* Falsetto Jones, the villain of the week on ''WesternAnimation/KimPossible'', has an extremely high-pitched voice due to a freak accident involving helium (hence his name).
* Alan the balloon from ''WesternAnimation/TheAmazingWorldofGumball''.
* An early ''WesternAnimation/BeavisAndButthead'' episode had the duo steal balloons from a vendor in order to get high from the helium, after they inhale it and comment how funny they sound they exclaim "Oh no, we're neutered!"
* WesternAnimation/DonaldDuck: TropeCodifier and he could be the {{Trope Namer|s}}. The [[Wiki/{{Wikipedia}} Other Wiki]] even has him as the Trope Namer!
* Averted with Plo Koon in ''WesternAnimation/StarWarsTheCloneWars'', who speaks in a low, deep voice, despite the fact that he breaths helium.
* ''WesternAnimation/TheLooneyTunesShow'': Daffy starts speaking like this in "Mr. Wiener" after he inhales a tank of helium to stretch is stomach to win a hotdog eating contest.
* ''WesternAnimation/{{Futurama}}'': The Planet Express crew have to rescue "helium miners" from ''inside the Sun''. Bender convinces them to sing Camptown Races.
-->'''Leela:''' Attention, helium miners! Can you hear me?\\
'''Miners:''' For God's sake, help us! We're in agonizing pain!\\
(''Fry, Leela and Bender giggle'')
* Inverted in ''WesternAnimation/TheSmurfs'' episode "The Magic Egg", where Clumsy gets a deeper voice when he is turned into a giant.
* Characters in ''WesternAnimation/TotallySpies'' speak in a high-pitched voice when [[SuperDeformed chibified]], but only in the sixth season.

[[folder:Real Life]]
* Creator/TonyShalhoub used it in the ''Film/MenInBlack'' movies, for the bits when Jack Jeebs's head is growing back after being blown off by either Agent J or Agent K, but the rest of the time, he uses the same voice he uses on ''Series/{{Monk}}''.
* This trope often shows up in works set deep underwater, like the book ''Literature/{{Sphere}}''. This is TruthInTelevision to some extent; the nitrogen in normal air becomes toxic at very high pressure, so deep divers breathe a gas mixture which has had some or all of the nitrogen replaced with helium. However, films in such settings often purposely ignore the effect when it should be present. Having live actors breathe helium for every line would be distracting to the audience, not to mention being somewhat dangerous and ridiculously expensive.
* A new trend around anime conventions: getting voice actors to say their characters' famous lines after inhaling helium. HilarityEnsues, usually.
-->'''Creator/TravisWillingham:''' My friends wanna know, "When you go out of town, what do you do?" "Oh, you know, [[BreadEggsMilkSquick eat cake... huff balloons...]] [[http://www.youtube.com/watch?v=YZFIxM7SWr0 make a big dumbass out of myself..."]]\\\
'''Creator/VicMignogna:''' [[Manga/FullmetalAlchemist Don't call me small]]--''[[SugarWiki/FunnyMoments (barely avoids headslamming the table)]]'' [[http://www.youtube.com/watch?v=lRq9Y4sMUMI I'll break off your feet and stick 'em on your head!]]"
* ''Disney/LiloAndStitch'': Chris Sanders when providing the voice for Stitch.
* {{Inver|tedTrope}}sion: [[http://www.youtube.com/watch?v=d-XbjFn3aqE sulfur hexafluoride]].