[[quoteright:215:[[Film/KillBill http://static.tvtropes.org/pmwiki/pub/images/killbilllist_6417.jpg]]]]
[[caption-width-right:215:[-Don't forget to [[OhWaitThisIsMyGroceryList buy milk]]-].]]

GottaCatchThemAll with a twist. The PlotCoupons or {{MacGuffin}}s in question have to be found... and then destroyed. Perhaps they are [[ArtifactOfDoom Artifacts of Doom]] that menace the existence of the world as we know it, or maybe they are a group of Villains that just appeared and instead of ganging up and going against TheHero, they decide to spread and be evil elsewhere.

Many a RoaringRampageOfRevenge plot will involve the hero hunting down each bad guy on [[EnemiesList his hit-list]] in this fashion and slowly working his way up to the BigBad behind it all for the final showdown. Or it may involve a villain [[EvilVersusEvil hunting down another]] BigBad and beating his minions, champions, and commanders, eventually leading to a showdown between the villain and the BigBad in order to become an AscendedDemon.

Compare ThereCanBeOnlyOne, EnemiesList and ShootEverythingThatMoves.

Not related to KillEmAll - not directly, anyway.



[[folder:Anime and Manga]]
* Being given a Manga/FutureDiary means you are now a candidate to become the next {{God}}. To claim the title, you have to be the only one left who has a Future Diary, meaning you have to kill any others you know about or [[RetGone erase]] them by destroying their Future Diaries. Oh, and there's a [[RaceAgainstTheClock time limit]]. You have until God dies to claim the title or else [[TheEndOfTheWorldAsWeKnowIt the world dies with Him]].
* The last StoryArc in ''Anime/DragonBallGT'' has Goku and Pan looking for the Seven Dragons formed by the bad energies gathered by the Dragonballs, and they have to destroy them to purify the balls and make them usable again. This could have presented a bit of a problem for them when one of the "evil" Dragons turned out to actually be a fairly decent guy, and a walking biohazard that was destroying the planet. [[BadGuysDoTheDirtyWork They were saved from any moral dilemma when he got defeated and absorbed by the most evil Dragon of all]].
* In ''Anime/StarDriver'', Takuto's goal is to destroy all of the Glittering Crux's [[HumongousMecha Cybodies]] so that Wako will be allowed to leave the island and fulfill her dream of becoming a pop idol in Tokyo.
* [[EldritchAbomination The Angels]] of ''Anime/NeonGenesisEvangelion'': [[CreatureHunterOrganization NERV's]] strategy is to kill them one by one [[SortingAlgorithmOfEvil as they invade]].
* The Poseidon saga of ''Manga/SaintSeiya'' has the heroes go and destroy 7 giant pillars below each ocean, to be able to destroy an even larger pillar in which Saori is trapped. Each pillar has a guardian of course, and 5 of those guards end up dead.
* Villainous example in ''Manga/DGrayMan'', where the [[BigBad Millennium Earl]] wants to destroy all Innocence. This may be made easier by the fact that one of the [[OneHundredAndEight 109]] Innocences is the Heart, which will destroy all the rest if it is destroyed.
* A Downplaying of this trope is the central plot of ''Manga/ZatchBell''. Although you don't technically kill your enemies (you just send them back to the alternate dimension where they came from), the effect is the same.
* ''Manga/RaveMaster'' uses this, where the group's quest is to destroy the Dark Bring (Shadow Stones).
* In ''Manga/{{Bakuman}}'', the main characters show their editor, Hattori, a story idea for a series about a world infested with demon dragons that has a sword with many demon dragons sealed inside. Every time one is killed, another emerges from the sword, and if the hero kills all of them without losing the sword to them, peace will be restored. Mashiro finds the story to be old-fashioned and stereotypical, but thinks it's worth showing to Hattori, and Hattori tells them they'll have to come up with a better idea than that if they want to go mainstream.
* Villainous example in Manga/{{Naruto}}- the Akatsuki are seeking to collect and extract all nine tailed beasts in order to form the original ten tailed beast. The extraction process is fatal to the [[SealedInAPersonShapedCan Jinchuriki.]]
* Kurapika in ''Manga/HunterXHunter'' is out for revenge with a double shopping list: Kill all the members of the Phantom Troupe that killed his tribe, and then retrieve the eyes that they stole from the bodies of his people.
* ''Anime/{{Shinzo}}'': While the overall MythArc is about Yakumo trying to find the fabled city of Shinzo, season 1 also set up a plot where the heroes had to confront the Seven Generals who started the Human-Enterran War and kill them to collect their cards. This plot is [[AbortedArc abandoned halfway through]] by the time they get to the third major villain on the list.

[[folder:Comic Books]]
* In the ''ComicBook/XMen'' novel series ''Time's Arrow'', our heroes have to take out the Time Arrows that threaten to delete parallel universes a la DC's Crisis on Infinite Earths. Or at least that's what it's supposed to look like at first.
* ComicBook/RomSpaceknight was on a quest to wipe out all the AlwaysChaoticEvil Dire Wraiths in the universe... or at least banish them to [[PhantomZone Limbo.]] He does encounter ''one'' Wraith who did a HeelFaceTurn after disguising himself as a family man and BecomingTheMask, but this Wraith gets killed by his comrades when they discover he isn't evil any more.
* ''Franchise/TheCrow'', in all its adaptations, sticks with the BackFromTheDead version of this.
* The premise of ''ComicBook/ScottPilgrim'', albeit a quirky spin on it in terms of the trope and its execution. In order to date the [[GirlOfMyDreams (literal) girl of his dreams]], Scott has to defeat her League of Evil Exes. In this case, "defeat" roughly translates to "inflict bodily harm until they explode in a shower of coins".

[[folder:Fan Fiction]]
* In ''[[https://www.fanfiction.net/s/11989539/1/Hakkōna Hakkōna]]'' and ''[[https://www.fanfiction.net/s/12023508/1/Kaitō-Kokoro Kaitō Kokoro]]'', Obake are creatures that can shapeshift into just about anything. Unfortunately, their powers made them [[CursedWithAwesome feared by humans]] and massacred as a result with [[spoiler:Kiku as the only survivor.]]
-->Obake. A subcategory of Yōkai, supernatural creatures of Japanese Shinto myth. Obake are beings that can take on any shape, from an inanimate household object to the most ravenous of beasts. However, despite that, Obake can be of various species, possessing various base forms; cat, dog, monkey, even human are just some of them. Obake have generally lived in peace, respecting all those around them. Secluding themselves from people, they are one with nature, in perfect harmony with it and each other as they live through existences which aren't limited by the passing of time. Everything was perfect until that fateful day...
* In ''Fanfic/PerfectionIsOverrated'', the goal of the [[ParodySue SUEs]] is to kill all the Himes, and the one who succeeds will seemingly be rewarded with the power to change the world as she sees fit. [[spoiler:In reality, she will be possessed by the Usurper]].

* In ''Film/KindHeartsAndCoronets'', Louis Mazzini, black sheep member of the D'Ascoyne family, kills off six members of the family in order to become the Duke of D'Ascoyne. Bonus -- the six D'Ascoynes (plus two more who save Louis the trouble by dying on their own initiative) are all played by Alec Guiness!
* The Immortals from ''Film/{{Highlander}}''. In the end, ThereCanBeOnlyOne. Some, like the protagonists, are content to coexist peacefully for the time being, but the evil ones are [[VillainOfTheWeek constantly coming out of the woodwork]] to cause trouble.
* Because Skynet has little information about Sarah Connor's 1980s whereabouts other than that she lived in Los Angeles at the time, as soon as he arrives Film/TheTerminator simply looks up "Sarah Connor" in the phone book and goes down the list killing anyone with that name - it even gets him labelled the "phone book killer" by the media.
* [[NoNameGiven The Bride]] of ''Film/KillBill'' literally has a list. She sets out to kill the members of the [[MurderInc Deadly Viper Assassination Squad]] who attacked her on her wedding day, murdered her fiancé, [[NoHoldsBarredBeatdown beat her into a coma]], and put a bullet in her head.
* ''Film/{{Tombstone}}'' - After Wyatt Earp's family is attacked by the red-sash wearing Cowboys, he declares, "From now on, I see a red sash, I kill the man wearing it."
* If you don't kill all ''Film/{{Gremlins}}'', you'd better try to [[GottaCatchThemAll get them all]] next time they come around.
* This is half the plot of ''Film/{{Faster}}'' (The other half being those chasing Driver).
* This is the basic premise of the film ''Film/KillList'' -- two {{Professional Killer}}s are given a list and contracted to kill everyone on it.
* The premise of ''Film/PartingShots'', where the main character Harry Sterndale, a cancer-ridden photographer with only six weeks to live, plans to kill a number of people who made his life a misery.
* In ''Film/BillyMadison'' one minor character is shown to have a neat little list titled "people to kill". Notable in that we discover this when he's taking the titular character ''off'' it after he called on the phone to apologise for bullying the former in high school years ago.
* In the 1945 pirate flick ''Captain Kidd'', the title character keeps a list of accomplices he intends to eliminate. The first time the list appears, he's ''adding back'' a name he'd already crossed out, because the man he'd previously left marooned on a coral reef has turned up alive.
* In 1990 ''Kid'' the titular character is killing his parents' murderers. Making it look like accidents. Subverted: he doesn't kill the last one -- the mayor -- he just tells the story to his children and they leave him. Alone in a town that hates him and is no longer afraid.

* Harry's quest in ''Literature/HarryPotterAndTheDeathlyHallows'' have him searching for Voldemort's [[SoulJar Horcruxes]], which keep him alive while they are intact.
* ''Literature/DanielX'' - The whole premise of the book series. Danny essentially has a big wanted list of alien criminals on Earth, and surprise surprise the one that killed his parents is number one on the list. The entire series basically revolves around him killing off or capturing the aliens on the list one by one, making his way to the one who killed his parents.
* In ''Literature/TheWheelOfTime'', although not necessarily required, Rand & Co. are killing off the 13 Forsaken one by one since they are trying to release [[{{Satan}} the Dark One]]. Their efforts are largely negated by the fact that most of the Forsaken are actually resurrected by the Dark One via a method of putting their souls into living bodies, something the good guys don't find out until just before the end of the series. As such, most of the baddies are truly killed in the FinalBattle.
* Creator/JackVance's ''Literature/TheDemonPrinces'' quintology has the protagonist tracking down each of the 5 beings who destroyed his DoomedHometown and enslaved all the survivors except for him and his grandfather.
* In ''[[Literature/MatthewSwift A Madness of Angels]]'', each section of the book consists of Matthew tracking down and killing or defeating the head of one of the subsidiaries of the Tower, until the climactic scene where he fights the head of the Tower itself. More or less.
* In the original novel ''Literature/{{Dracula}}'', the vampire hunters have to track down and destroy the 50 boxes of earth Dracula transported to London from Transylvania and scattered throughout the city so that he will have no safe haven to go to when the sun rises or to change his shape.
* In the Literature/StarTrekDeepSpaceNineRelaunch novels, Iliana Ghemor is on a mission to kill every version of [[spoiler: Kira Nerys]] in the multiverse .
-->“I don’t fault you for not seeing the big picture, Captain. After what was done to me, it took me a while to understand what I needed to do so that I could be whole again. But when I meet the Prophets, they’ll see inside me, just as they did with your Emissary. They’ll understand what I need to get my life back. And I’ll use the Soul Key to find every other [[spoiler: Kira]] that has laid claim to a piece of my soul”.
* In ''Literature/TheHungerGames'', twenty-four adolescents are thrown into an arena to fight to the death until only one is left alive. Throughout the book, the main character frequently recounts how many competitors are left.
* ''Literature/BattleRoyale'' is similar to ''The Hunger Games'' in that it involves a group of young people being forced into a game where the objective is for each of them to kill their competitors and to be the last boy or girl standing. In this case, the number of kids who are still alive is noted at the end of each chapter.

[[folder:Live Action TV]]
* Sylar to other superpowered people in ''Series/{{Heroes}}'', although it's more like a combination of both this and GottaCatchThemAll.
** And in season 2, [[spoiler:Adam Monroe]] targets the original founders of the Company as part of a RoaringRampageOfRevenge.
* Uther's RoaringRampageOfRevenge against magic users in ''Series/{{Merlin}}'' probably counts.
* ''Series/KamenRiderDecade'' has the titular hero being told that, in order to avert the collapse of TheMultiverse, he has to travel to the realities of the last nine Heisei ''Kamen Rider'' series and kill all of the heroes. He refuses, of course, and helps the Riders. [[spoiler: It turns out that the collapse proceeded apace, accelerated by the villains but inevitable with or without them. When Decade was provoked into going to his SuperpoweredEvilSide, slaughtering all Riders as Decade Fury, the worlds, no longer being forced together by the Riders' powers, were all restored to their original states - including the slain Riders. It turned out plan A ''was the right one'' and EverybodyLives in the end.]]
* ''Series/KamenRiderDrive'' has to kill all 108 [[RidiculouslyHumanRobots Roidmudes]] to save the world from their [[EndOfTheWorldAsWeKnowIt rampage]]. It is as [[BlatantLies simple]] as it sounds. Individual numbers get crossed out on a checklist as the story goes on.
* Ziggzagged in ''Series/KamenRiderExAid'': [[DeadlyGame Kamen Rider Chronicle]] can end only if a player clears all the games it consists of and clearing a game ''usually'' means defeating its [[MonsterOfTheWeek Bugster]]. First stage Bugsters are simply video game characters, so defeating them is the only way. Second stage Bugsters are video game people and can be reasoned with. CR Crew uses a picture overview of all games to plan their next steps rather than as a "we have to kill so and so" list.
* The nineties show ''Series/{{Brimstone}}'' features a policeman brought back from hell (it's complicated) by the devil to return a number of escapees to hell the hard way (killing them, though the vast majority are only vulnerable in the eyes.)
* The entire premise of ''Series/{{Arrow}}'' at the first season; Oliver even has a literal list to work from and cross names off of.
* Arya Stark in ''Series/GameOfThrones'' recites the names of the people she wants to kill every night before she goes to sleep. She's nine years old.
* Omar from ''Series/TheWire'' is found to have a list of people from the Stanfield Organization he intends to kill. He only had a chance to cross out one name...
* This is part of the Thinker's plot in ''Series/{{The Flash|2014}}'' Season 4. He provoked the heroes into freeing the Flash from the interdimensional prison in the Speed Force, unleashing a wave of dark matter on the passengers of a bus in close proximity of the opened portal, turning them into metahumans. And the Thinker wants to steal the powers of all these "[[InSeriesNickname Bus-Metas]]" and [[AllYourPowersCombined add them to his own]], in a method that also involves taking their lives.

[[folder:Tabletop Games]]
* In FASA's ''TableTopGame/{{Earthdawn}}'', in order to kill a Horror one must first kill its physical body, then travel to the astral plane and kill its astral body.
* The ultimate goal of the Necrons in TabletopGame/{{Warhammer 40000}}: by exterminating all life (including bacteria), they close off the Warp (an alternate dimension essentially made of emotion), the only power that can stop them. Fortunately, most of the Necrons are still dormant.
* Liliana Vess from ''MagicTheGathering'' made a DealWithTheDevil - well, several devils - for eternal youth and beauty and power and all that good stuff, in exchange for which the demons would get her soul. Then she decided that, while the youth and beauty and power were all well and good, she'd ''also'' like to keep her soul. Cue Liliana going and hunting down each of the demons to permanently terminate the contract. [[spoiler:One of the demons, Griselbrand, was trapped in a magical vault on the plane of Innistrad. Good thing for the people of Innistrad that when Liliana shattered the vault, she [[NiceJobFixingItVillain also freed their archangel Avacyn]]...]]

[[folder:Video Games]]
* The Colossi in ''VideoGame/ShadowOfTheColossus''.
* The evil path in ''VideoGame/KnightsOfTheOldRepublicIITheSithLords'' is hunting down and assassinating what is left of the Jedi Council.
* ''Franchise/FinalFantasy'':
** The four elemental Fiends from [[VideoGame/FinalFantasyI the first]] game.
** And the [[VideoGame/FinalFantasyIX ninth]].
** Also, a sidequest involving the eight dragons in [[VideoGame/FinalFantasyVI the sixth]], and the advanced versions in the UpdatedRerelease.
** In ''VideoGame/LightningReturnsFinalFantasyXIII'' it is possible to hunt most of the monsters to extinction. The final one of each breed is bright pink, tougher, and has better drops. There is an extermination side quest.
* The various Franchise/{{Metroid}} evolutions in ''VideoGame/MetroidIIReturnOfSamus'' and the remake ''[[VideoGame/MetroidSamusReturns Samus Returns]]''. And, consequentially, the various forms of X in ''VideoGame/MetroidFusion''.
* The initial goal of SEES in ''VideoGame/{{Persona 3}}'' is to defeat the twelve Full Moon Shadows that have been popping up ever since the protagonist first joined the party. [[spoiler:[[NiceJobBreakingItHero Unfortunately, in doing so, they release]] the herald of [[EveryoneHatesHades Nyx]], the AnthropomorphicPersonification of death, who had been split in twelve by Aigis and [[SealedEvilInACan sealed inside the protagonist ten years ago]]]].
* The members of the ''United Assassins Association'' in ''VideoGame/NoMoreHeroes'' and ''VideoGame/NoMoreHeroes2DesperateStruggle''. As the main character, Travis has to murder the top ten ranked assassins in the nation, one by one, to rise through the ranks and gain the top spot for himself.
* Most of the NES and SNES ''VideoGame/MegaMan'' games have the titular character hunting down Robot Masters to take their powers and eventually fight their evil master, Dr. Wily himself.
* In ''VideoGame/SonicAdventure 1'', E-102 Gamma's story following his rebellion against Robotnik is to find and "liberate" his fellow E-100 series robots. "Liberate" in quotes because he ''destroys them and frees the captured animal powering them''. [[spoiler:The last one to die is, of course, Gamma himself]].
* Halfway through ''VideoGame/SeikenDensetsu3'', the eight God Beasts are released into the world, and the heroes are forced to go out and slay each one of them. [[spoiler:Of course, that just plays straight into the villain's plan.]]
* The six dragons in ''VideoGame/ChronoCross''. Well, you can get by without beating the Black Dragon, but that's only if you fail to do it the right way.
* To some extent, the four sentinels in ''VideoGame/WildARMs5''. They're guarding four towers that have to be destroyed before you can fight the BigBad Volsung.
* ''VideoGame/MagicalGirlLyricalNanohaAsPortable: The Battle of Aces'' has the Dark Pieces and Materials, beings formed from the remnants of the [[EldritchAbomination Darkness of the Book of Darkness]] that must be taken down lest the Darkness of the Book of Darkness [[BackFromTheDead return]].
* Though you don't actually ''kill'' them, the whole point of the main series ''Franchise/{{Pokemon}}'' games is to defeat the Gym Leaders in each city by knocking out their Pokémon, so you can defeat the Elite Four and subsequently, the regional Champion. The Frontier Brains can qualify as [[BonusBoss Bonus Bosses]] in regards to this goal, though.
* The Desert Treasure Quest in ''VideoGame/RuneScape'' involves running around the whole continent and defeating four guardians who hold four diamonds you need to access an ancient pyramid, where the eponymous treasure is located.
* The "Gnomes Are Evil!" sidequest in ''VideoGame/FableIII''. Due to a magical spell gone wrong, 50 garden gnomes were given sentience and then teleported all over Albion. You have to hunt them down and shoot them, which transports them back to their owner. Fortunately the gnomes are foul-mouthed, annoying little jerks.
** ''Fable II'' is similar, with 50 foul-mouthed stone gargoyles who you must shoot.
* The ''Franchise/AssassinsCreed'' series basically embodies this trope. From the main plot of every game revolving around assassinating a group of villains, to the optional sidequest of killing the 60 Templar Knights in the 1st game.
* ''Franchise/TheLegendOfZelda'':
** The Gold Skulltulas in ''VideoGame/TheLegendOfZeldaOcarinaOfTime''. Good luck [[ThatOneSidequest finding the whole hundred of them]]. Also doubles as GottaCatchThemAll as you must collect all the tokens they drop as well. Same case in ''VideoGame/TheLegendOfZeldaMajorasMask'', though the hunt is restricted to two {{Bonus Dungeon}}s.
** ''[[VideoGame/TheLegendOfZeldaTwilightPrincess Twilight Princess]]'' has 60 Poe souls for you to collect in a side quest by killing Poes. They're almost everywhere and some are only visible at night.
* The goal of ''VideoGame/{{Crackdown}}'' is simply to kill about 20 different gang bosses, and a skilled player could simply charge off and get to work immediately upon starting a new game. Of course, leveling up your skills and finding new weapons will help out a lot.
* If one goes through the Ruling End of ''VideoGame/HyperdimensionNeptuniaMkII'', one must kill [[spoiler: ALL the other goddesses just to power up a sword to finally kill Magiquone. However, [[DownerEnding it fails.]]]]
* Going for HundredPercentCompletion in ''VideoGame/GrandTheftAutoIV''? Among other things, you'll need to kill all ten most wanted criminals on each island (Broker/Dukes, Algonquin, Alderney), and you'll also need to kill all ''two hundred'' pigeons scattered across Liberty City.
* ''Videogame/GrandTheftAutoV'' ups the ante with the final mission. What do you do when [[spoiler:you are blackmailed by two of your worst enemies to kill one of your companions]], and you will die if you don't comply? Why, you simply have to [[spoiler:TakeAThirdOption and ''kill everyone who opposes your band'']].
* The main objective of Arena mode in VideoGame/TeamFortress2, your team's goal is to kill ''everyone'' on the opposing team while they try to do the same to you. Whichever team still has at least one player standing at the end wins.
* ''VideoGame/HalfLife2'' has an achievement where you need to kill 333 Antlion grubs. It's easily the most [[ThatOneAchievement infuriating achievement]] in the game.
* The idea of the ''VideoGame/{{Hitman}}'' series is to kill the targets in the level as an elite-assassin clone known only as [[NamesToRunAwayFromReallyFast Agent 47.]]
** ''Videogame/Hitman2016'' has the Patient Zero campaign, specifically the third and fourth missions, which requires you kill 3 random militia members who've been infected by a Death Cult doctor, who you also have to kill. This is done with a sniper rifle in a Colorado military camp, while the other mission has you going around a high tech hospital in Hokkaido, Japan to make sure the virus doesn't leave the hospital facility.
* In ''VideoGame/DarkSouls'', the player needs to collect the remaining Lord Souls to open the way to the First Flame. How do you get the Lord Souls? By killing the badass ''gods'' you see in the ActionPrologue.
* ''VideoGame/S4League''[='=]s Chaser mode. Each round, one player is randomly designated as the Chaser and has to kill all of the other players, who have to [[HoldTheLine defend themselves until the time runs out]]. The Chaser gets bonus points for killing whoever has the most points of anyone alive, and gains extra points if they kill every opponent which also deprives the victims of any points (15 if alive when time runs out, 5 if dead but other players survive).
* This is the goal of every ''VideoGame/MonsterHunter'' game, since the majority of quests ask you to kill a certain monster, which you can carve afterwards to get useful parts to build armors and weapons with. There are occasions where you're asked to capture a monster alive, but it's a rarer occurrence.
* ''VideoGame/RomancingSaga2'' has the Seven Heroes, while ''VideoGame/RomancingSaga3'' has the four demon lords.
* In the final mission([[spoiler: itself a [[RoaringRampageofRevenge Roaring Rampage of Revenge]]]]) in ''VideoGame/GhostRecon'': Future Soldier, you and your squad hunt down a series of targets until you get to the Big Bad, [[spoiler: which is then [[ExactWords smashed by a train.]]]]
* Most individual missions in ''VideoGame/XComEnemyUnknown'' are played this way: To succeed, you have to kill or disable every alien in the zone. There are a couple of {{Escort Mission}}s where you just have to get one character to the exit area (possibly with a couple of tasks on the way), and to win the final mission and the game, you just need to kill one particular alien (though it's hard to get to him without killing almost every other alien on his ship).
* In ''VideoGame/{{Okami}}'', there are four sidequests in which Amaterasu is tasked to defeat a group of enemies. The enemies can be identified by having exorcising arrows inlaid in their bodies. They're in Shinshu Field, Taka Pass, Ryoshima Coast and Kamui.
* ''VideoGame/TheOutfoxies'': Seven hitmen were contracted to kill seven art collectors. Each one was also [[ContractOnTheHitman hired to kill one of the other hitmen]]. You're one of the seven. You don't know who has your contract. Answer? Kill all six of the others.
* A few of the ''VideoGame/SaintsRow'' games have the Hitman series of diversions, which will give you a list of targets to kill, along with instructions of how to draw them out. Each kill nets you some money and respect.
* In ''{{VideoGame/XCOM}}'', most missions don't end until every extraterrestrial on the map is dead.
* [[VideoGame/CallOfDutyBlackOps Dragovich... Kravchenko... Steiner... all MUST die!]]
* The Genocide/No Mercy route in ''{{VideoGame/Undertale}}'', which leads to the worst ending, requires you to systematically hunt down and kill every last monster in an area. If you miss even one you get shunted into a neutral ending instead.
* All the ''VideoGame/{{Sinjid}}'' games require you to do this. ''Battle Arena'' tasks you with killing every monster in the game (something you can only fully achieve on [[HarderThanHard Terminator mode]], since the lower difficulties end after a certain amount of levels), ''Shadow of the Warrior'' tasks you with killing every human enemy to prepare for a war (and getting OneHundredPercentCompletion requires killing every monster found in the game, which is [[BrutalBonusLevel no easy feat]]), and ''Sinjid'' tasks you with killing all the warlords loyal to the [[BigBad Shogun]] to end another war and get the protagonist's captors to free him so he can continue his [[ClearMyName initial mission to find his master's true killer (he was falsely charged with said master's murder and they agreed to let him go if he helped them)]].
* The Chaos Saga of ''VideoGame/AdventureQuestWorlds'' has the protagonist setting out to take down the Thirteen Lords of Chaos to stop Drakath from destroying Lore. [[spoiler:Things get complicated when not only does King Alteon of Swordhaven become the Twelfth Lord of Chaos as a result of tragic events brought on by the Chaorruption he suffered at the very beginning of the saga, but the final Lord of Chaos turns out to be YOU!]]
* ''VideoGame/TheElderScrollsVSkyrim'' has an example of this as a side quest. Eight powerful Dragon Priests are scattered throughout Skyrim, each one bearing a mask with special perks. There's a shrine that can be decorated with each mask as well. Naturally, you must hunt down and kill all eight of them to restore the shrine. Your reward for this is another mask.

* Othar Tryggvassen, GentlemanAdventurer! from ''Webcomic/GirlGenius'' has this as his primary goal concerning sparks. Yes, including himself (last).
* ''Webcomic/ElvenLacryment''. The lead character is on a quest to rid the world of the orcs that destroyed her village.

[[folder:Web Original]]
* The Dark Generals in ''Literature/SailorNothing''.
* ''Literature/TheHoldersSeries'' - of course, it's a tossup as to whether the results of bringing them together or preventing them coming together are worse, and if they are all destroyed they will "unite in the destroyed state", so it's rather a no-win situation.

[[folder:Real Life]]
* Antibiotics and pesticides: The danger of bacteria and pests developing immunity to chemicals make it important that these chemicals be used sparingly, but when they are used, they should be used in sufficient amounts and for sufficient durations that the pests are truly wiped out.
* Vaccines: Same as above, the ultimate finish line would be the complete eradication of a/all disease. Still a long way to go, but we're making progress.