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->''"This is a bad experiment! We are bad people!! WHY DID WE USHER FORTH THE GREEN APOCALYPSE!?"''
-->-- '''[[VideoGame/HalfLife Gordon Freeman]]''' during the [[ApocalypseWow Resonance Cascade]], ''Machinima/FreemansMind''

StockPhrase used whenever that [[ScienceIsBad nasty old "science"]] inevitably [[FantasticAesop messes up royally.]]

The basic setup is simple: You have an outpost, a laboratory, a factory, or other facility dedicated to the research and production of technological marvels, staffed with [[ForScience flighty scientists]] and [[AmbitionIsEvil ambitious persons]] pursuing a goal with the aims of profit, peace, or other [[JustThinkOfThePotential potential applications.]] Oh. And did we mention that the research is on [[ScaleOfScientificSins cheating death?]] Or that the forest that those free market capitalists are clear-cutting just happens to be rumored to have an ancient IndianBurialGround somewhere within it?


[[{{Pride}} Well]], [[TemptingFate let's]] [[PhlebotinumRebel see]] [[TurnedAgainstTheirMasters here]].

In the course of their reasonable, maybe even noble quest to advance scientific knowledge, make a profit, help humanity, design a doomsday device, or otherwise undertake a high risk/high reward venture, ''something'' will have [[TitleDrop gone horribly wrong]].

The variations are endless. Perhaps the non-polluting energy source [[PoweredByAForsakenChild actually]] taps into the delicately balanced forces locked in a CosmicKeystone or drains the planet's LifeEnergy. Or the hunger-killing super-wheat is actually [[GreenAesop a super-weed that destroys all ecosystems]]. And that's for purely ''peaceful'' things. Weapons of any sort will have things go horribly wrong on a [[ApocalypseHow cataclysmic scale]]. The "completely loyal" robot workforce has a [[Creator/IsaacAsimov programming flaw]] that makes them [[TurnedAgainstTheirMasters revolt]]. Maybe the SuperSoldier program [[WithGreatPowerComesGreatInsanity inherently causes insanity]], [[{{Mutants}} mutation]], or plain old [[WhatMeasureIsANonSuper megalomania.]]

These researchers will observe [[NoOSHACompliance lax safety standards]], laxer morals, and be prone to [[ProfessorGuineaPig test things out on themselves]] or [[StrappedToAnOperatingTable unwilling visitors]]. The CorruptCorporateExecutive will callously and maliciously disregard all warnings, even for basic safety and good PR.

Expect these people to send out a DistressCall or chronicle the debacle in an ApocalypticLog, be visited by a group [[ClosedCircle whose car broke down,]] or have things go wrong when the [[DisastrousDemonstration stockholders/government oversight committee comes to view their achievement]].

This is comparable to a FreakLabAccident, except at the beginning of a story. Heck, a lot of SpeculativeFiction serves no purpose ''but'' to have something Go Horribly Wrong.

See also CameBackWrong for when an attempt at bringing someone BackFromTheDead Goes Horribly Wrong. For when the experiment would be successful but is deliberately sabotaged, see SpannerInTheWorks. In more cynical works, this may leave the character thinking "WhatHaveIDone?". When Gone Horribly Wrong results in a project or product being scrapped immediately after its debut, it's a DisastrousDemonstration.

[[GodzillaThreshold Of course]], it can [[FromBadToWorse always get worse]].

Compare with GoneHorriblyRight, where the project in question does whatever thing/task it was intended to do, often with flying colors, but, does it in a way that is really, really, really, really fear-inducingly horrible enough to make its creators want to [[SealedEvilInACan stuff it into a can and bury it]], anyhow. An EpicFail is this being {{played for laughs}}.



[[folder:Anime & Manga]]
* In ''Manga/{{Claymore}}'' there are women who are [[HalfHumanHybrid half human and half demonic]]. They hunt monsters that [[ToServeMan eat human guts]]. However, they may lose control of their powers and turn into huge, man-eating monsters called [[FaceMonsterTurn Awakened Beings]]. In the first generation of the organization that creates these warriors, many warriors were male. However, [[GenderRestrictedAbility men can not control these powers very well]], so almost all of them have awakened quickly.
* Anime/{{Digimon Tamers}} Takato orders his Digimon to Digivolve to the Mega Level...what results is a Mega whose mere existence threatens both the Digital and Real Worlds. Oh, and whose name is literally Meggidromon. As in, ya know, the battle of the Apocalypse!
* Anime/{{Daitarn3}} and Anime/NeoHumanCasshern. Creating cyborgs who are superior in every way to normal humans? [[SarcasmMode There is absolutely no way]] [[TurnedAgainstTheirMasters this is going to backfire]].
* ''Manga/ElfenLied''. Keeping that diclonius called Lucy seemed so easy, but as it turns out, it wasn't. "FromBadToWorse" is a mild way of putting the series.
* ''Manga/FullmetalAlchemist''. Try to bring back mommy dearest to life? [[EquivalentExchange I don't think so.]]
** Scientists create an [[spoiler:''immortal army'' that hates you because you put their souls in terrifying, freakish bodies and now they hurt ''all the time'']]? Yeah, shooting them is a good idea. That will kill them for sure. Let's do that.
* ''Manga/FrankenFran'': Fran really just wants to help people, but she seldom thinks through the non-biological consequences of her operations.
** Though, admittedly, only half the time. [[spoiler: The rest [[GoneHorriblyRight goes horribly right.]]]]
* ''Manga/{{Judge}}'': All Hiro wants to do is have a chance to confess his feelings to his brother's girlfriend, so he tells a little lie to his brother. [[TheLostLenore This leads to his brother Atsuya being run over by a truck]].
* ''Manga/{{Naruto}}''.
** Everything [[spoiler: Itachi]] has planned since the beginning concerning [[spoiler: his younger brother. After killing his entire clan, he couldn't kill Sasuke. Itachi's goal was to make his little brother be seen as a hero to Konoha, going as far as to die by his brother's own hands. Tobi told Sasuke all of this]] and [[GoMadFromTheRevelation now...]] [[LaughingMad well]], [[AxCrazy you]] [[SanitySlippage know]] [[FaceHeelTurn how]] [[FallenHero it]] [[StartOfDarkness all]] [[EvilFeelsGood turned]] [[OmnicidalManiac out]].
** This problem was temporarily fixed [[spoiler:by the revived Hokages.]] Unfortunately Sasuke took another message out of their story: [[spoiler:the world must be united by a common enemy, so he will be that enemy]].
** The Sage of Six Paths shared his chakra with the people of the world so that it would act as a bond between them, fostering understanding and peace. Instead they created ninjutsu and used chakra to fight one another. [[spoiler:This is why Madara views the society created by the Sage's ninshu as a "failed world" and believes that [[AssimilationPlot a more direct approach]] is needed]].
** Jiraiya loosens Naruto's seal in order to test the extent of Naruto's control over the Kyuubi's chakra. His action results in the destruction of the village they're in and a [[WaveMotionGun Bijuu-dama]] to his chest.
** Danzo is a more long-term example, as a fair amount of the tragedies that happened in the story can be ultimately traced back to his underhanded actions, in his obsession to "protect" Konoha, arguably creating more enemies and threats that didn't exist in the first place. Just about everything he did backfired horribly for the village, but of course, it didn't matter to him.
* In ''Anime/NeonGenesisEvangelion'', the Second Impact (a cataclysmic event which changed the world forever) is strongly implied to have been caused by an experiment on a huge god-like being Gone Horribly Wrong. This begs the question of what kind of result did they think they would get. "I'll just stick this thingy into the huge god-like being that we don't under..."(Recording irreparably damaged from this point on)
* Apparently getting used in experiments too much in ''Anime/GingaDensetsuWeed'' caused Kaibutsu to be the monster he had become when we first see him.
* ''Anime/PokemonJirachiWishmaker'': Butler spends the bulk of the film trying to capture Jirachi and use his power to resurrect a Groudon fossil in order to get revenge on Team Magma for expelling him from the organization. He ultimately succeeds in using Jirachi to do so, but instead of an actual Groudon, he ends up with a MadeOfEvil EldritchAbomination that only ''resembles'' Groudon. He's [[MyGodWhatHaveIDone rightfully horrified]] by the result, and helps Ash and co. destroy the monster after it absorbs his LoveInterest, Diane.
* ''Anime/{{Macross 7}}'' reveals the Protoculture experiment that went so horribly wrong it indirectly lead to the destruction of their entire species. They attempted to power their living superweapons with energy from an AlternateUniverse with no physical matter in it. Problem was, the energy they siphoned from that universe turned out to be ''intelligent'', and immediately took control of the superweapons. Termed the Protodeviln, they started a galactic war that, ultimately, the Protoculture did not survive.

[[folder:Comic Books]]
* Responsible for quite a few supervillain origins. For example:
* ComicBook/NormanOsborn creates a compound that grants super-strength and healing powers. And turns him into the insane '''Green Goblin'''.
* The New Mexico experiments with Gamma Radiation went very wrong for [[ComicBook/IncredibleHulk Dr Bruce Banner]].
* [[ComicBook/SonicTheHedgehog Doctor Finitevus']] first use of his Chaos Siphon suit turned him into a MadScientist and [[EvilAlbino bleached his fur.]]
** Thrash The Devil had been told echidnas were evil for turning the race of Tasmanian Devils into dog-like Devil Dogs for ages. He then goes and banishes what's left of the echidna race to another dimension out of pure spite.
* ''Comicbook/{{Empowered}}'''s superteam was looking for an easy win for the PR, so they try to bring down the obscure villain Willy Pete. It doesn't go well ''at all''.
* Comicbook/{{Daredevil}}'s attempt to reform the Hand as its new leader in the ''ComicBook/{{Shadowland}}'' storyline failed horribly [[spoiler: after the Hand's ''true'' leader, the demon known as The Beast, possessed him.]]
* A real life example of this is the origin of the "Fatal Attractions" storyline in ''X-Men'', wherein ComicBook/{{Wolverine}} has his adamantium stripped from his body. During a writer's meeting, Peter David suggested the concept... ''as a joke'', parodying the extremes the franchise had gone to. To his horror, the other writers kept spinning it and created one of the [[DorkAge most infamous X-Men stories of all time]].
* In DC's ''ComicBook/{{Flashpoint}}'' event, [[spoiler:Barry Allen's attempt to recreate the FreakLabAccident that made him Franchise/TheFlash]] goes horribly wrong and burns all of his skin off.
** The entire event happened because [[spoiler:[[NiceJobBreakingItHero Barry's attempt to save his mother from Zoom]] caused a TimeCrash.]]
* In the MarvelUniverse, there have been attempts to recreate Project Rebirth for decades ever since Dr. Erksine was killed just after enhancing Steve Rogers into ComicBook/CaptainAmerica. Unfortunately, they have all backfired, most often creating supervillain maniacs and monsters like the 1950s Captain America and Nuke.
* ComicBook/{{Morbius}} tried to counter his fatal blood disease but the experiment instead turned him into [[OurVampiresAreDifferent a living vampire]].
* ''Franchise/{{Superman}}'' and ''Franchise/GreenLantern'' villain Cyborg Superman (Hank Henshaw) has two (in a meta sense) in his origin story. His backstory is modeled after that of the ComicBook/FantasticFour, which already involves a trip into space going Horribly Wrong. If that wasn't bad enough, the expied origin story goes ''more'' horribly wrong when, instead of developing useful powers, two of Henshaw's teammates die horribly as a result of their mutations and his wife commits suicide, either because of what she's become or from seeing what's happened to her husband. Henshaw himself winds up as a disembodied soul inhabiting technology, goes insane, and spends most of his time [[DeathSeeker trying to die]].
* ''ComicBook/SpiderMan'': During the Six Arms Saga, Peter, having had enough of being Spider-Man, creates a potion intended to [[BroughtDownToNormal strip him of his spider-powers]] for good. Rather than nullifying his powers, the potion increases them, causing him to sprout four extra arms.
* In ''[[ComicBook/RobinSeries Robin]]'' Strader Pharmaceuticals develops a drug designed to give the user super-strength. It of course ends up being a PsychoSerum that turns the users homicidal in addition to giving them strength and slowly and horrifically breaks down their bodies killing them.

[[folder:Fan Works]]
* The Nightmare Virus from the ''FanFic/TamersForeverSeries'' is ''much'' more sadistic and [[TakeOverTheWorld power-hungry]] than its programmer ever intended it to be.
* In ''FanFic/GloriousShotgunPrincess'', [[Franchise/MassEffect Cerberus]] continues its trend, [[LampshadeHanging with characters joking about it on several occasions]]. In particular, Liara half-expected their project to resurrect Shepard to end in their usual "experiment killed all the scientists and took over the base" fashion. The fic is also known for giving rise to the [[MemeticMutation famed]] "Cerberus Taco Cart Theorem" which states that most (if not all) projects that Cerberus undertakes will kill all the scientists and take over the base.
* ''Fanfic/TheConversionBureau'' is a ''fanfic'' that went horribly wrong. The author of the original fanfic, [[WordOfGod Blaze, has gone on the record to state]] that the fic was solely written as WishFulfillment and as an explanation on his hypothesis on why Equestria had no humans. Instead, thanks to ham-handed writing, he attracted a sizable {{hatedom}}, some [[MadArtist crazy authors]] with stories based on their own views set in his universe and a [[NeverLiveItDown permanent reputation]] as an [[MisanthropeSupreme absolute misanthrope]].
* ''[[http://www.fanfiction.net/s/9145129/1/Naruto-Shinobi-Institute-of-Perfomance-Analysis Naruto: Shinobi Insitute of Performance Analysis]]'' mixes this with GoneHorriblyRight in the case of Itachi using Tsukiyomi (a genjutsu he barely understood) on Sasuke. The result? A homicidal sociopath that kills enemies and prisoners at every opportunity and brutally murdered at least one classmate before he graduated.
* ''Franchise/LyricalNanoha'' fanfic ''Toward the World's End'' gives us this combined with {{Too Dumb to Live}}. The TSAB detect a huge anomaly in the void. What do they find? An artificial universe that appears to be doing something to other universes. What do they do? ''Shoot at it with ALL WEAPONS!''. The thing creates shields out of nothing, and then fires back with some weapon that the TSAB can't even idenitfy. They manage to stop it obliterating Mid-Childia, but the radition that spills over destroys life and creates apocalyptic conditions on millions of planets in a ton of other universes. Including the one that Nanoha, Yuuno and OC Protagonist Arthur are on... Earth. If that wasn't bad enough, the radiation also unleashes {{Eldritch Abomination}}s that are ONLY capable of destruction. [[NiceJobBreakingItHero Nice going, TSAB]].
* In ''FanFic/MegaManDefenderOfTheHumanRace'', Gamma and the Civil Defense Tower are this. Both projects were hijacked by Wily and nearly doomed the world.
* In ''Fanfic/FlashFog'', Caligo Manufacturing of Cloudsdale developed a new industrial cloud formula - one that is much more resilient and almost impossible to disperse compared to normal clouds. It works so well, the tanks can't hold it and the whole mixture becomes a fog bank. The whole story circles around how plain hard it is to eliminate [[FogOfDoom the fog]] by conventional means.
* ''Fanfic/AVoiceInTheWilderness'' presents an OriginStory for the Borg Collective of this sort. Preserver scientists on a planet in the Delta Quadrant were attempting to create {{nanomachines}} for medical purposes, but the nanites somehow merged with an ArtificialIntelligence that spread through the planet's {{Alternet}}, becoming the first Borg Queen, One of One. The present-day Queen happened later, after the surviving Preservers managed to capture and imprison One of One's central processor.
* The entire premise of ''Roleplay/LordsAmongTheAshes''. It is decided that the best way to display the skills of the [[WebAnimation/{{RWBY}} Huntsman Academies' leaders for the Vytal Festival]] [[InsideAComputerSystem is to place them inside a simulation for ten days]] [[YearInsideHourOutside so that they can rule over a kingdom of their own for ten weeks]]. Cinder's virus then interacts in an unexpected manner with the SDC's simulation software, causing the time dilation to change from x7 to '''x365'''.

[[folder:Films -- Animation]]
* In ''WesternAnimation/CloudyWithAChanceOfMeatballs'', Flint Lockwood creates a device that makes it rain food. At first, everything is fine, but through constant overwork, the machine develops a mind of its own, and starts sending down bigger and bigger food, threatening to destroy the world.

[[folder:Films -- Live-Action]]
* The film ''Film/AlienResurrection'' had scientists clone Ripley in hopes of creating a Xenomorph for [[JustThinkOfThePotential potential military applications]]. Things go horribly wrong when the cloning gave the aliens more grey matter than the scientists, allowing them to escape and wreak havoc.
* The ''Franchise/{{Terminator}}'' series. Because it's SUCH a good idea to make computers smarter than you then hand them military control. How come the only one smart enough to keep the Terminators from learning too much is Skynet? And yet ''Series/TerminatorTheSarahConnorChronicles'' reveals the existence of machines who have decided to fight Skynet on their own.
* The reason they have to drill into ''Film/TheCore'': [[spoiler:secret government experiments with a giant earthquake-causing weapon has somehow ruined the Earth's EM field by causing the core to slow down and eventually stop]].
* ''Crack In The World'': Scientists try to tap magma from the Earth's core by detonating a nuclear bomb deep underground. This turns out to be a very bad idea indeed. Considering the fact that you can tap magma from the Earth's core at one of the hundreds of active volcanoes all over the ''surface'' of the world, they probably deserved to have it go horribly wrong.
* ''Film/TheDarkCrystal'' is set [[AfterTheEnd 1,000 years after]] the urSkeks, a [[SufficientlyAdvancedAlien hyper-advanced]] species, made the ill-advised and arrogant (if somewhat noble) decision to try and eliminate their darker natures; a decision that literally caused a near-apocalypse-level event. This single choice wrought, in its 1000-year aftermath, the eventual near-extinction of one race, the decimation of a second, and the creation of beings of pure evil that ruled over the planet for an entire millennium.
* In ''Film/DeepBlueSea'', scientists try to cure Alzheimers by harvesting the brain matter of super-smart genetically modifed sharks. What went horribly wrong? Well for one thing, experimenting with really aggressive sharks, underwater, [[TooDumbToLive on a platform in the middle of the ocean]], with no way of easy escape might not be the best idea ever ... [[spoiler:A shark fucking ate Samuel L. Jackson, for one thing.]]
* The movie ''Film/EventHorizon'' is about a [[GoneHorriblyRight brain-twistingly successful]] attempt at FTL travel... that then promptly Went Horribly Wrong. [[HyperspaceIsAScaryPlace Really]], [[{{Gorn}} REALLY]] [[GeniusLoci horribly]] [[EldritchAbomination wrong]].
* ''[[Film/TheFly1958 The Fly]]''. [[TeleportersAndTransporters Teleportation experiment]] is upset by a literal fly in the ointment. And [[Film/ReturnOfTheFly then it happens again]]. [[Film/CurseOfTheFly Twice]]. And then Creator/DavidCronenberg [[Film/TheFly1986 gets hold of the idea]] and [[Film/TheFlyII does it twice]] as well and ten times as ugly.
* ''Film/JurassicPark''. A zoo which houses dinosaurs? [[TemptingFate What could possibly]] [[WhatCouldPossiblyGoWrong go wrong here]]?
* Nearly every other movie based on a Creator/MichaelCrichton story follow this trope, with the exception being ''The Great Train Robbery''.
* Omni Consumer Products "improved" police robots went Horribly Wrong in both ''Film/RoboCop1987'' and ''Film/RoboCop2.''
** Murphy succeeded, but only because he's a special case. As shown by failed cases in the second film, most cyborgs don't handle their new existence well. Of course, using a drug-addicted criminal as a cyborg-policeman is probably not the best idea.
* The big reveal of ''Film/{{Serenity}}'' involves an experimental chemical named Pax. Given [[http://en.wiktionary.org/wiki/pax#Noun_2 the name's meaning]], you can guess what it was ''supposed'' to do, and for the most part, its problem was that it [[GoneHorriblyRight worked too well]]. But on a small segment of the population... [[spoiler: You know the Reavers? Yeah, this is where they came from.]]
* In ''Film/SonOfGodzilla'', an experiment trying to control weather plans to start by freezing the tropical island it's happening on. Well, radio interference prevents the detonation of a specific device at the right time, resulting in a massive heat wave, tropical storms, and the already rather large (ten feet long or so) praying mantises living on the island growing to {{Kaiju}} proportions.
* ''Film/{{Species}}'': They try to grow an alien child. Then they try to dispose of it when the experiment is shut down. ''Not happening.''
* ''Film/TotalRecall1990'': a routine implantation of false memories at Rekall goes haywire.
** [[spoiler:[[AlternativeCharacterInterpretation Or worked perfectly]].]]
* TheFilmOfTheBook ''TimeMachine'''s TheEndOfTheWorldAsWeKnowIt is triggered when humanity starts excavating more living space into the moon with nuclear weapons. When the hero uses the titular machine to go forward a few years, he finds himself in a dystopia and the fragments of the moon in the sky are getting bigger and bigger...
%%* The [[Series/MysteryScienceTheater3000 MST3K]] episode ''Film/ItConqueredTheWorld'' where SCIENCE almost lets a giant Venusian pickle take over the world. Too bad that the chief head science guy "learned almost too late that man is a feeling creature? and, because of it, the greatest in the universe..." This episode also spawned its own {{Meme}} and possible alternative title for this trope in "He tampered in God's domain..."
%%** Incorrect, that episode was Ed Wood's ''Bride of the Monster'' wherein Bela Lugosi attempts to create a "rice of pipples" by turning people into atomic supermen. It doesn't end well for him at all.
* ''Film/BattlefieldEarth''. Beyond the obvious reference, how else can you describe the plot [[AlternateCharacterInterpretation from the Psychlo perspective]]? You have a planet completely under your thumb, and one greedy mid-manager does an experiment on a subjugated race, which ultimately results in it gaining the knowledge and power to wipe out your home world and all of the occupying forces.
** [[spoiler: And the reason he bothers is he's so desperate to go back home that he's willing to do ''anything'' to get the money to buy his way out of the trouble he caused himself, making this trope also apply to the government official who exiled him to Earth in the first place.]]
* In the 2008 ''Film/TheIncredibleHulk'' film, the army's experiments with Gamma radiation gives birth to the Hulk, and [[spoiler: [[GeneralRipper Thunderbolt Ross]] and [[PsychoForHire Emil Blonsky's]] experiments with the [[ComicBook/CaptainAmerica super-soldier serum]] leads to Blonsky becoming the Abomination]].
* In ''Film/XMenFirstClass'', [[spoiler: Hank's serum to allow him to change his feet to normal ends up transforming him into Beast.]] Doubles as ForegoneConclusion.
** Stop it Erik, these men are JustFollowingOrders! Really, Charles?
* The premise of ''Film/MeanCreek'' is that a group of kids devise a plan to get revenge on an overweight, troubled bully named George on a boating trip, effectively humiliating him in the process. [[spoiler:However, George ends up being accidentally pushed off of a boat and into the lake below. He is unable to swim and drowns.]]
* In ''Film/{{Pixels}}'', humans send into space videos of them playing then-popular computer games as a message of peace. The aliens who receive it believe it to be a declaration of war to be fought with those games.
* ''Film/DasExperiment'' is based on the StanfordPrisonExperiment, but goes further. Within just a few days the guards are terrorizing and humiliating the prisoners to keep order, right up to abusing their position of power to commit murder and rape. The head scientist was even aware how quickly the experiment was escalating, he just chose to ignore it ForScience.

* ''Literature/TheDayOfTheTriffids'' by Creator/JohnWyndham. No one knows for sure where such weird plants came from. But they produce high-quality oil and that's what matters, JustThinkOfThePotential! Of course, the oil's even better if their deadly stings are left intact, but simple safety measures are enough, right? And yes, that meteorite shower is... ''strange'', but all the more reason that we cannot miss such an opportunity! Let's ''all'' go and look! Right?.. It's only natural... [[spoiler: Wait, we just became hapless food for ''plants''?]]
** ''TroubleWithLichen'' averts this by having the chief scientist [[spoiler:and the researcher who semi-stole the discovery]] anticipating the problems before they start.
* In ''Literature/TheCityAndTheStars'', by A. C. Clarke, the hyperadvanced galactic civilization of the far future sets out to create a fully disembodied intellect so as to create a being that may comprehend the universe without the defining bias of physical form, which it hopes will be its crowning achievement in a galaxy it no longer feels challenged by. They succeed, but [[spoiler: the first attempt creates the Mad Mind, which is vast and powerful, but, alas, as the name suggests, quite insane. The galactic civilization eventually wins the subsequent war to contain the Mad Mind, but at the cost of widespread galactic-scale devastation, with most of the Milky Way's stars blown up or prematurely aged by the conflict's end.]]
** Even though tired beyond measure by this ordeal, the galactic civilization [[spoiler: tries again and this time succeeds, creating Vanamonde, a similar intellect that is sane and friendly. It is suggested that Vanamonde's ultimate destiny is to battle the Mad Mind, at the end of time when the prison containing it fails.]]
* Creator/MichaelCrichton made his living writing novels about science that Goes Horribly Wrong.
** With the exception of ''Next,'' where Science does reasonably fine, except for a few cases of rapidly aging a couple of drug addicts that it managed to cure anyway (there were 5, at most). It's greed that goes horribly, horribly wrong.
*** Also ''The Great Train Robbery'', which is basically a Victorian caper story.
* Downplayed and parodied in Mikhail Bulgakov's short story, "Literature/HeartOfADog". The protagonist, Professor Preobrazhensky, experiments in the area of transplantation of animal organs to humans and vice versa, with the purpose of rejuvenation. His final experiment is transplanting a human's pituitary gland to the brain of a stray dog, which is adopted by him at the start of the story. The reader expects that the experiment will lead to the creation of a violent and homicidial mutant, but it's not true, the experiment's results are completely safe to humanity: just a short and hair-covered homunculus, who is almost as intelligent as a human. What's the catch? Well, the pituitary belonged to a persistent criminal and alcoholic, and the resulting hybrid personified the worst qualities of both humans and dogs - a heavy-drinking, lazy, violent thug, who is also pathologically cruel and sadistic to stray animals, especially to cats, due to his dog origins. He also sexually harasses Preobrazhensky's female servants and steals money from him. At the end, Sharikov (that's the homunculus's surname, which is taken from the dog's nickname "Sharik") becomes so annoying and cruel, [[spoiler: Preobrazensky's assistant Dr. Bormental strangles Sharikov almost to death, then they remove the pituitary gland from his brain, and he becomes the dog again.]]
* ''{{Mutant 59}}: The Plastic Eaters'' by Gerry Davis and Kit Pedler. Look, we really need to do ''something'' with all that plastic junk anyway. Look how many things are made of plastics. So why couldn't microbiologists conduct some experiments privately? After all, little buggers eat only freakin' plastic, so even if some strain ''could'' go loose it's still completely safe, right? At worst, they'll eat... Oh. By the way, if low-oxygen organics decay, what can we get as a result?
* In ''Literature/TheGodsThemselves'' by Creator/IsaacAsimov aliens help humanity build the source of clean unlimited power which will, unfortunately, [[spoiler: blow up the sun.]]
* ''Striking Steel'' by Lukins. Defend your planet with a replicating anti-personnel complex! This [[MechanicalLifeforms metal hive's]] [[MacrossMissileMassacre mini-rockets]] shred anything its radar sees moving: small arms, aircraft or shuttle, can even incapacitate armored vehicles. Then little robots collect the scraps and grow thousands of new complexes -- no extra burden for your war-torn industry. They have proper communication and Friend-or-Foe, so you can keep them away from ''your'' troops and objects, but it's very secure, don't fear they will be hacked, in this you're ahead of the enemy. WhatCouldPossiblyGoWrong? [[spoiler:Accumulation of their tolerable limits with copying, for once. Especially in the radio resonators of Friend-or-Foe and control. Three generations, and you're in DeathWorld. And the time for Wi-Fi hacking is just too limited when all this ReverseShrapnel rips your antennae.]]
* A rare example of sociology going horribly wrong is Joe Haldeman's ''Literature/TheForeverWar''. Instead of conscripting all the stupid people into the army, TheGovernment conscripts all the smart and fit people for military service. Needless to say, things go horribly wrong on Earth soon afterwards.
* One of the recent books in the Franchise/StarWarsExpandedUniverse, "Crosscurrent", involved an old Imperial experiment [[spoiler: to create Force-sensitive clones by combining the DNA of various Jedi and Sith. Suffice to say that the result involved gratuitous amounts of human sacrifice and cannibalism.]]
** Pretty much any attempt to clone Force-sensitives end up with insane Force-powered clones. It's speculated in universe that this is due to the Force itself rejecting or being confused by these strange beings.
** Well before ''Literature/GalaxyOfFear'', two scientists were performing experiments on the nature of life on Kiva, since the Kivans had offered to host them. [[BigBad Gog]] knew that the latest experiment would backfire and create a WorldWreckingWave that destroyed all life on Kiva, but he convinced the other that it was safe. The other - Mammon [[spoiler: Hoole]] - was [[MyGodWhatHaveIDone utterly horrified]] by the result and blamed himself. So to Mammon it was this trope, to Gog it went exactly as he'd been hoping.
* The FirstContact on Rakhat in ''Literature/TheSparrow.'' About half the book is flashbacks to the events that led up to the mission; the other half is the "present day," when the damaged remains of the crew come back to tell the story.
* In the Creator/DaleBrown novel ''Wings of Fire'', the Night Stalkers were supposed to only go into Libya to destroy some missiles. Then [[spoiler: Paul dies in the process of stopping the missiles and Wendy goes missing fending off a Libyan retaliation.]]
** In ''Executive Intent'', a KillSat is used in an attempt to destroy a bunch of terrorists and the missiles they hijacked. [[spoiler: It misses and kills many civilians.]] Things get worse from there.
* In ''Discworld/CarpeJugulum'', the vampires try to get AcquiredPoisonImmunity to various vampire weaknesses by constant exposure to them, included a wide variety of holy symbols. Unfortunately, when their will breaks, they start seeing holy symbols ''everywhere''.
* In Creator/JohnBrunner's book ''The Dramaturges of Yan'', a race of lonely aliens decided to convert their planet into a spaceship, using the rotary force of the planet's moon. Guess what: [[spoiler: It shattered]] When they get a chance, they try again. [[FromBadToWorse It gets worse]]: [[spoiler: This time the planet is destroyed.]]
* ''Distant Rainbow'' by the Strugatski Brothers: Rainbow is the name of a lush planet which is used for experiments with teleportation. But one day the experiments [[spoiler: create the Deadly Wave, which begins to consume all organics on the planet from poles onwards, dooming it.]]
* In Robert Jordan's ''Literature/TheWheelOfTime'' series one man's plan to seal away [[UltimateEvil the Dark One]] ends up causing every man who uses magic to go horribly insane and rot while still alive. This continues indefinitely into the future as well...[[spoiler: until [[TheChosenOne the Dragon Reborn]], our protagonist, restores the magic to its prior purity.]]
** An even more extreme example in the same series happens before this, when all the trouble began when the greatest magic users in history discover a new and amazing source of power, without realizing that they are tapping into [[UltimateEvil the Dark One's]] prison, thus unleashing SealedEvilinaCan and destroying civilization.
* In Creator/AlastairReynolds's ''Literature/RevelationSpace'' universe, while the origin of [[PlanetEater Greenfly]] is never explicitly revealed, it's strongly implied to have originated as some ancient race's (or distant future humans'... don't ask) terraforming device of sorts (as the artificial planetoids it transforms all planetary matter into are technically habitable).
* ''The Rising'' and ''City Of The Dead'': let's just run this particle accelerator and...oops, looks like we found the SealedEvilInACan that will [[KillEmAll wipe out our species]] with a ZombieApocalypse. Joy.
* In the children's book ''Fish Out of Water'' by Helen Palmer and P.D. Eastman, a boy is instructed to feed his goldfish only a certain amount of food, and no more. But the goldfish still looks hungry, so he gives him a little more, and then the fish starts growing and growing.
* In ''Literature/{{Coda}}'', the music started as ways to calm people after the war, as medications were in rare supply. Then the people in power got hold of it...
* In ''Literature/TheStand'', the U.S. Army should have expected that trying to design a killer virus as a biological weapon would probably go wrong. But, they didn't, and it escaped...
* In ''Literature/AnimalFarm'', the theory of Animalism compared to what it became in practise. This, of course, parallels Communism perfectly.
* ''Literature/WildCards'': The Wild Card virus was invented by psychic aliens in order to give themselves superpowers and an advantage over rival houses. They decided to test it on humans (due to the strange coincidence of humans and Takisans being physiologically near-identical). After it was released, it was discovered that ninety percent of victims "drew the Black Queen" (mutating so horrifically they died in minutes), nine percent "drew the joker" (mutating but surviving), and one percent "drew the ace" (remaining physically unchanged but gaining superpowers). This made the virus absolutely worthless as a method of improving themselves, as a one percent success rate is too low for even the most amoral person to use on their own people. It also made it worthless as a weapon, since one percent success is too high to use on your enemies.
* In ''Literature/TheMortalInstruments'' there is Jonathan Morgenstern. [[BigBad Valentin]] wanted to create a [[{{Nephilim}} nephilim]], who is also partially a demon, to create a whole new kind of shadowhunters. And although Jonahthan was much stronger, faster, and more resilient than the other nephilim, he had been corrupted to evil by the [[InTheBlood demonic blood]].

[[folder:Live-Action TV]]
* ''Series/GameOfThrones'': Tywin's first lesson to Tommen about being king is wisdom, specifically the wisdom to know when someone else knows more than you do. This is a not-so-subtle attempt by Tywin to set himself up as the power behind the throne. However, Tywin dies not long after, so the indecisive Tommen is left with people who only want to manipulate him for their own gain including Margaery, making him an even bigger PuppetKing than his brother. As a result of the machinations of the High Sparrow and his StupidEvil mother, King's Landing is well on its way to becoming a theocracy, with Tommen having been easily conned into enabling it because no one has taught him to stand up for himself.
* In ''Series/{{Smallville}}'', let's just say that literally every last one of ComicBook/LexLuthor's experiments have Gone Horribly Wrong.
** ''Truth'': A truth serum that almost gets [[spoiler:Chloe]] killed. ''Twice''.
** ''Onyx'': Messing with lasers and [[GreenRocks green kryptonite]] leads to [[spoiler:the creation of black kryptonite, which splits Lex into good and evil Lexes.]]
** ''Power'': A suit of sorts that bestows {{Physical God}}hood is stolen by [[spoiler:Lana]].
* ''Series/DoctorWho'' has naturally dabbled in this, with a key example being the classic Third Doctor story ''Inferno''. A scientist team attempts to drill through the Earth's crust to access an energy pocket to be used for fuel, but the pocket happens to come with nasty side-effects; namely a toxic slime that reduces humans to primitive ape-men and a [[ApocalypseHow colossal volcanic explosion that will roast the entire planet]]. The story mostly takes place in a parallel universe, so we get to see the Earth (well, a fascist-controlled version of it, but Earth nonetheless) get destroyed in real-time with loving [[TearJerker detail]]. Thankfully the Doctor was able to stop it before the cataclysm came to pass in his world.
* This trope is used in a light, funny way in the episode of ''Series/TheBigBangTheory'' entitled "The Vengeance Formulation." To get back at Kripke for humiliating him on NPR, Sheldon devises a scheme. He concocts a solution with the help of Leonard and Raj that has the ability to slowly expand and get all foamy, and puts some in the ceiling tiles of Kripke's office. However, the plan goes horribly wrong when Kripke enters his office accompanied by the president of the university and the board of directors. The foam breaks through the ceiling and drenches all of them. It goes FromBadToWorse when a pre-made video of Sheldon [[EvilGloating gloating evilly]] comes on Kripke's monitor, so the bigwigs now all know that he did it. He also names Leonard and Raj as accomplices.
* ''Series/TheIncredibleHulk'' TV show.
--> "Doctor David Banner: physician, scientist; searching for a way to tap into the hidden strengths that all humans have. Then an accidental overdose of gamma radiation alters his body chemistry."
* ''Series/{{Lost}}'': The DHARMA Initiative has gone horribly wrong at least once, with "the incident" that necessitated pushing the button every 108 minutes. (The demise of most DHARMA members may count, too, after we find out the whole story.)
* ''Series/TheXFiles'' is proof positive that you should not let scientists anywhere near a laboratory without very strict supervision by a non-governmental agency.
* Many of the [[SugarWiki/FunnyMoments funniest moments]] of ''Series/WhoseLineIsItAnyway'' happen when a game goes terribly wrong. Such as Wayne's H-O-R-W-A-R-D song, Ryan breaking the light on Drew's desk with his head, and the legendary "Quacking Elephants" sound effect game.
** Or Ryan Stiles eating an entire tin of Altoids mints as a joke ''after'' a sketch ended. (Colin Mochrie had given him a quick kiss as part of the prior sketch.) It didn't take long for him to realize what a really bad idea it was.
* In the ''Series/{{Dollhouse}}'' episode "Omega" has Alpha's plan to [[spoiler:turn Echo into another Alpha by causing her to undergo a composite event]] go horribly wrong... for Alpha. [[spoiler:Since the bulk of Echo's imprints were good guys, Composite!Echo is a moral person, and turns against Alpha. From the perspective of everyone else, the experiment went horribly ''right'']].
** Actually, it's made pretty clear that it's not the whole "bulk of the imprints" thing - it's who they were originally. [[spoiler: Alpha was originally a serial-killer-in-training so he of course was evil, whereas Echo was (mainly) a good person back then so she was good. In the future, Alpha's good imprints have eventually turned him into a good person and he's scared of turning back to who he originally was]].
** ''Epitaph One'' is a bonus episode set in a future where ''everything'' has gone horribly horribly wrong.
* Pretty much all science on ''Series/BuffyTheVampireSlayer'' with the possible exception of Warren's robots. Whether it's mutant steroid fish men, demonic Frankensteinian cyborgs, the animated dead looking for a girlfriend, or just the plan to collect the school library info on a database, if it's on the Hellmouth it will work and then start killing people.
* ''Series/StarTrekTheNextGeneration'' has several:
** "Half a Life": They attempt to revitalise a star, and instead it goes supernova.
** "New Ground": they test a "soliton wave", which will allow ships a warp without a need for a warp drive, but [[spoiler: it destroys the test ship and threatens to destroy the target planet as well.]]
** ''Series/StarTrekTheOriginalSeries'' has the episode ''The City on the Edge of Forever'', where in an alternate timeline, [[spoiler: the survival of Edith Keeler led to an influential peace movement which later delayed US entry into WWII, resulting in UsefulNotes/AdolfHitler winning the war and the Space Age never happening. [[FridgeHorror Everyone else in the galaxy is presumably screwed, too, as there is now no]] [[Series/StarTrekEnterprise Jonathan Archer to stop the Sphere Builders]]]].
* This seems to be humanity's [[PlanetOfHats hat]] in ''Series/SpaceAboveAndBeyond''. Create a race of androids to be slaves? Congratulations, you get a RobotWar. Create a race of GattacaBabies to fight the androids and get, at best, TeethClenchedTeamwork. You could be forgiven for thinking humanity is the ''villain'' faction in this show.

[[folder:Puppet Shows]]
* On an episode of ''WebVideo/TheFundayPawpetShow'', Simba is dared to eat an entire pack of the new Listermint breath strips when they were first introduced. Not a pretty sight.

* [[http://www.youtube.com/watch?v=4aBUH3ILq6Q Barrett's Privateers: ]] The singer's character is convinced by the lure of easy fortune to join a privateer ship whose condition is somewhat less than perfect even before departure. Three months of deterioration are described in awful detail and ''only then'' do they engage their first target, [[spoiler: which turns out to be armed far more heavily than they are.]] It all ends horribly badly, with only one mutilated survivor.
* Sting's ''Something the Boy Said.'' At the end of the song, all the characters who started out so blithely and fearlessly are dead except for the singer [[spoiler:and even he is too terrified to look behind him as he leaves the scene of the disaster, in case he sees his own corpse.]]
* The US Army paratroopers' song [[https://www.youtube.com/watch?v=5HtVYr9aKRM Blood on the Risers]]. The young paratrooper readies for his first jump and does everything right ''except'' checks his static line (the line attached to the airplane itself which releases the main parachute automatically). Normally a reserve parachute is used should the main parachute fail. The trooper falls in bad position, deploys his reserve parachute in panic, gets tangled and he bounces. [[spoiler:"To bounce" is skydivers' lingo, meaning "to land on unsurvivable speed".]] [[{{Squick}} The rest is best left on reader's imagination.]] "Risers" are the four straps which connect the parachute lines to the harness.

[[folder:Tabletop Games]]
* Happens all the time in ''TabletopGame/GeniusTheTransgression''. The number one cause is letting one of the {{Muggles}} touch your machinery. As these wonders don't really work on ''actual'' science, which gets imposed when this happens, this tends to drive them haywire instantly in many, many fun ways.
* Each Lineage in ''TabletopGame/PrometheanTheCreated'' started with one human trying to raise the dead for whatever reason - companionship, curiosity, slavery - and getting bitten hard in the ass by this trope. Prometheans themselves can fall prey to this trope, as they need to produce another Promethean in order to complete their [[ToBecomeHuman Pilgrimage]] -- and if they screw it up, they spawn a number of [[CameBackWrong Pandorans]] that will turn on them and try to eat them alive.
* Happens every now and then in the backstory of ''TabletopGame/{{Warhammer 40000}}''. Not infrequently, the result is the Imperium destroying the planet where it has gone wrong.
** Someone asked along the line why, 40,000 years in the future, the Imperium seems to not have any robots at all, at most an automated defense array or like that. Because, tens of thousands of years in "the past", they DID have robots all over the galaxy...until they [[TurnedAgainstTheirMasters decided they didn't want to be slaves any more]] and started a war that almost annihilated the human race and all but destroyed humanity's entire technological base. Thus started a ban that, millennia later, has been incorporated as sacred law into the tech-worshiping religion of the Mechanicum. That's basically the [[CrapsackWorld best case scenario]] when something goes wrong here.
* Happens ''all the time'' in ''TabletopGame/{{Ravenloft}}'', where ThingsManWasNotMeantToKnow seem to be a required course in any university science program.
* Any given mission in ''TabletopGame/{{Paranoia}}'' will inevitably go horribly wrong, as will all the experimental gadgets. In fact in Alpha Complex getting a new pair of boots can go horribly wrong. This is as it should be, as the universe runs on unleaded high-octane RuleOfFunny.
* Everything wrong with the universe in ''TabletopGame/MageTheAwakening'' is a result of someone lighting some blue touch paper he shouldn't have, and breaking the universe as a result. The False Awakening is a good example - it resulted from an impatient mage's attempt to ''force'' her Sleeper boyfriend to Awaken, and exists as a contagious form of twisted ascension that drives its bearers to destroy themselves and large chunks of the scenery. It can be cured by a true Awakening, but if these were ''easy'' to induce, there wouldn't ''be'' False Awakenings...
* [[ExactlyWhatItSaysOnTheTin Pretty much the entire point of]] ''Fiasco''.
* How Florida got drowned in ''TabletopGame/{{Trinity}}'', as recounted in "America Offline": a young Aberrant (a superhuman) with power over the oceans was concerned about climate change in Florida, her home state, and attempted to stabilize the Gulf Stream. Unanticipated resonance resulted in massive ocean waves that killed millions of people, including the Aberrant herself.
* ''TabletopGame/YuGiOh'':
** Natalia and Noelia summoned the Steelswarm to fight the Fabled, but that backfired as Natalia lost her life.
** Happened again when Avance tried to revive Emilia using the power of Photomirror/Soulmirror. The ritual turned Avance into the monstrous Levianima.
* ''TabletopGame/RocketAge'': The Planet Killer Rocket for the Ancient Martians. The mutated slug controlling Dr Ritterbach would count as another.

[[folder:Theme Parks]]
* This is the plot of a lot of the thrill rides at Ride/DisneyThemeParks. It started with [[Franchise/StarWars Star Tours]], [[NewerThanTheyThink which opened in 1987]]. Before that, the "plot" was to just explore the place. When Star Tours opened, almost every ride afterwards followed the same concept.

[[folder:Video Games]]
* ''VideoGame/{{BioShock|1}}'' had an Objectivist Utopia go horribly wrong. Basically, the resident PsychoSerum caused everyone go insane, then PresidentEvil had a civil war with TheMafia. Not to mention the hideous tumours and deformation on the infected , zombie little children draining blood from 'angels' (read: corpses) while accompanied by massive armoured brutes fused into their diving suits. If this wasn't more than enough, by the sequel we have a SENTIENT FETUS in a tank, a sub-Christian Communist cult (responsible for the above, and headed up by an exceptionally unpleasant example of the 'Splicers', a creature whose infected muscle tissue grows over it's clothes. Body Horror taken to the nth degree.
* If you're going to make an MMORPG set in a ComicBook universe, you're probably contractually obligated to lampshade this at least once. ''VideoGame/CityOfVillains'' brings us the surprisingly GenreSavvy [[http://wiki.cohtitan.com/wiki/Vernon_von_Grun Vernon von Grun]], a [[CardCarryingVillain card-carrying]] MadScientist who not only expects things to go wrong, ''he looks forward to it'':
-->''This is terrible! Nothing bad is happening! We did everything perfectly, but something has gone wrong! My plans are all off-track. Mad science isn't supposed to go wrong like this! But the true test of a mad scientist is how much worse you can make things go wrong.''
** His "colleague" [[http://wiki.cohtitan.com/wiki/Doc_Buzzsaw Doc Buzzsaw]] appears to be not so savvy:
--->''Oh, what has science wrought? I sought only to turn a man into a metal-encased juggernaut of destruction powered by the unknown properties of a mysterious living crystal. How could this have all gone wrong?''
* ''Franchise/{{Halo}}'': Keeping samples of the unstoppable parisitic lifeform you just wiped out all sentient life in the galaxy in an attempt to starve for study? Fine, if you lock them away in a secure installation. It's not your fault that thousands of years later, a bunch of CargoCult religious fanatics decided that it would be a good idea to around, carefully ignoring your pointed warning.
* ''VideoGame/ChronoTrigger'' has everything start going bad with Lucca's teleporter experiment. In hindsight, though, [[BecauseDestinySaysSo that was probably preordained.]]
* In ''Franchise/DeadSpace'', pretty much anything [=EarthGov=] does with the Markers goes horribly wrong in the form of Necromorph outbreaks. They want to study the Markers due to the fact that the Markers seem to produce enormous amounts of energy, and humanity is in a bit of a resource crisis at the moment. They are aware of the risks of people going insane, scribbling on the walls, killing each other and causing Necromorph outbreaks, and they take precautions against such, but they inevitably fail...
* ''Videogame/{{STALKER}}'': The backstory of the Zone:[[spoiler: A group of Soviet scientists set out to cure mankind of violence, grief and greed by manipulating a psionic field around the Earth. Their experiment backfires and damages the psi field to a point where it breaches the physical plane and begins horribly warping the area around Chernobyl]].
** And if that wasn't bad enough[[spoiler: It is heavily implied that the damage they caused is irrevocable, and the breach will continue to grow until the entire Earth is consumed by the Zone]]]
* The plot of the ''VideoGame/{{Doom}}'' games has [[TeleportersAndTransporters experiments in teleportation]] going horribly wrong due to the teleportation technology tapping into Hell itself, allowing the demons access to our dimension in the process and unleashing a plague of Hellspawn upon the moons of Mars. The Marines are called in to deal with the threat, and are wiped out except for [[OneManArmy one survivor who has to kill his way through the forces of Hell]]. And then, [[DemonicInvaders things]] [[HellOnEarth get worse]].
* The Peak 15 facility on Noveria in ''Franchise/MassEffect'' was build to hold the queen of an insect species that once almost destroyed the whole galaxy and develop a method to directly control her brood. Not only did the part about controlling the brood didn't work out, the "holding the queen" part didn't work either. When asked a week later in the midst of a hideous disaster what Peak 15 was built for, the captain of the security guards doesn't seem too surprised:
-->'''Captain Ventralis''': Labs like these exist to do stupid crap that gets people killed.
** [[VideoGame/MassEffect2 It all seemed harmless...]] The Overlord experiment was anything but. Particularly for [[spoiler:poor David Archer, the guy at the centre of the experiment]].
** This happens all the time with [[NebulousEvilOrganisation Cerberus]]. Most of their projects (almost all of which are massively amoral and unethical) tend to backfire horribly upon them. In the Citadel DLC of the third game, Joker lampshades how frequently this happens, with Shepard being an example.
*** This is known as the "Cerberus Taco Cart" theorem in the fandom (based on [[http://i.imgur.com/JwpyHd4.jpg this]] Webcomic/ThreePanelSoul page): any Cerberus project will eventually go rogue and kill all of their guys, usually taking over their base in the process. For a full list of failed projects, see the Cerberus section on [[Characters/MassEffect1AntagonistsAndNpcs this page]].
** Tali's loyalty mission in ''VideoGame/MassEffect2'': [[spoiler:Tali had been sending deactivated geth parts to her father, Rael'Zorah, as part of an experiment with the intent of trying to figure out a way to control them. Unfortunately, when the geth parts were reconstructed into complete geth bodies and brought online, the geth proceeded to kill everyone onboard the ship where the experiment was conducted, including Rael.]]
** The Leviathans created [[spoiler:the Catalyst]] in an attempt to find a solution to the danger that organic life will inevitably create synthetic life, which will then destroy its creators. [[spoiler:The Catalyst]] created the Reapers as a response.
* In ''[[VideoGame/FirstEncounterAssaultRecon F.E.A.R.]]'', saying that things have Gone Horribly Wrong is a ''massive'' understatement. Harlan Wade, whose actions throughout the game's backstory very nearly propel him right past the ''MoralEventHorizon'', should've known that having his psychic and ''batshit insane'' daughter impregnated and stealing her children away from her to engineer them into {{Super Soldier}}s wouldn't end well. And it doesn't, once Alma gets free.
* Say it with me now: ''VideoGame/FinalFantasyVII.'' Contains both the "power source draining the planet's LifeEnergy" and "borked SuperSoldier program" varieties.
** And the whole "Let's make a materia that can destroy the entire world! Who'd misuse that?" [[spoiler: turns out to be a subversion. While it seems insane, it turned out to be the best way to stop Jenova.]]
** ''VideoGame/FinalFantasyVI'' also has the SuperSoldier variety. Hey, [[TwoOutOfThreeAintBad two out of three]] non-OmnicidalManiac Generals ain't so bad!
*** [[BadassNormal Leo]] wasn't part of the experiment. That gives it a 50% Omnicidal Maniac output.
*** And they learned how to do it right after they tried it on [[PsychoPrototype Kefka]], anyway.
* ''VideoGame/WildArms3'' features the Council of Seven and their Yggdrasil system, which sought to produce nanomachine colonies to modulate the amount of nutrients and resources of their planet, Filgaia, to rejuvenate it, so it could restore the amount of life it once had on it. And guess what? The project worked. Right up until the scientists realized that Yggdrasil was sucking the planet dry of absolutely every life resource it possibly had.
* In the ''VideoGame/{{Geneforge}}'' world, experiments go wrong so often that laboratories, workshops, and schools are designed with the expectation that this will happen sooner or later. Some are built on uninhabited island, some are [[CollapsingLair built underground]], and some just rely on thick doors to [[SealedEvilInACan seal the place off]].
** Which makes the Shapers the most GenreSavvy and sensible group on this page, since they know what they do is dangerous and try to control the experiments and consequences as much as possible. Almost all the strife and catastrophes in the series come from intentional misuse of Shaping.
** And some of those Shapers used their GenreSavvy to contribute to making things worse. The Geneforge itself is a history of things gone horribly right, from Trakov to the latest Ur-monsters. Even the rebels most interested in applying its powers admit that its as terrible as it is successful.
* ''VideoGame/HalfLife'':
** ''VideoGame/HalfLife1''. A routine... [[BuffySpeak whatever-it-was-they-were-trying-to-do]] procedure, but "Unforeseen Consequences" happen.
** ''VideoGame/HalfLife2: Episode Two'' reveals that actually [[spoiler:everything went JustAsPlanned. Though we still have no idea what the [=GMan=] intended by goading the Combine to invade Earth and suffer a massive slave uprising 10 years later.]]
** In the same universe, ''VideoGame/{{Portal}}''[='s GLaDOS=] can be considered an experiment Gone Horribly Wrong. Or an experiment [[WildMassGuessing gone]] ''[[WildMassGuessing right]]''. Look -- there's no evidence [=GLaDOS=] failed as a de-icing system, and she is [[StayingAlive arguably alive]].
* In ''VideoGame/QuakeIV'' every mission seem to do this [[spoiler: first your drop ship get shot down nearly killing you,then the EMP bomb plan fails, then you get turned into a Stroog, then you get shot into battle in a flying coffin (drop pod)which crashes.]] Basically then entire game is a series of plans gone wrong that somehow works out in the end.
* In ''VideoGame/TimeSplittersFuturePerfect'', [[spoiler: Jacob Crow's attempts at eternal life result in zombies and the Timesplitters.]]
* ''VideoGame/{{Transarctica}}'''s backstory for the new Ice Age is "[[MeaningfulName Operation Blind]]", a plan to cool global warming by kicking up dust with [[DeusExNukina nuclear weapons]] at the poles.
* ''VideoGame/SystemShock'': Let's just say that SHODAN wasn't designed to do what she did. [[spoiler:SHODAN was messed with before things got worse, though.]]
* ''VideoGame/OutpostTwo'': Eden's terraforming microbe was intended to break apart organic molecules and release oxygen to make New Terra into an earth-like planet in a single generation. Organic molecules like the ones ''in our bodies''. Needless to say, it gets loose and starts eating everything on the planet.
* In ''VideoGame/{{Prototype}}'', there were two virus-based experiments. One, Blacklight, was a case of GoneHorriblyRight. The other, Redlight, which Blacklight was based upon, was more of a Gone Horribly Wrong. Among other things, instant ZombieApocalypse as soon as the latter gets released. This is why you don't try to create ridiculously powerful bioweapons ''without off-switches'', folks.
* In ''VideoGame/TraumaTeam'', [[spoiler:Albert Sartre]]'s research into the [[spoiler:Rosalia]] virus ultimately ended in an entire university becoming infected and dying, him going insane and [[spoiler:murdering Rosalia]] before similarly succumbing, and ultimately [[spoiler:a massive part of the US population becoming infected with the virus.]]
* In ''VideoGame/{{Freelancer}}'', it is implied that the massive NegativeSpaceWedgie nebula in the Texas system was caused by an incident at a jumpgate research laboratory. The details are unclear, but it can't have been pretty.
* In ''{{VideoGame/Gauntlet}}: Legends'' and its re-release Dark Legacy, Garm attempts to summon the Demon King Skorne and use his power to usurp his older brother, Sumner, as the ruler of the Eight Realms. To do this, he requires the thirteen Runestones, but after a long time searching, Garm only manages to find twelve. Growing impatient, he goes ahead with the ritual anyways without the thirteenth Runestone, and manages to summon Skorne from the Underworld. Lacking the final Runestone, though, Skorne breaks free from Garm's control and crushes him to death, then proceeds to lay waste to the Realms.
** Subverted in the true ending of Dark Legacy [[spoiler:when Garm absorbs power from Skorne's remains to begin his own campaign to conquer the Realms.]]
* In the ''VideoGame/{{Fallout}}'' series, most of the underground Vaults seemingly designed to spare the population were in fact huge-scale social experiments designed to test their residents in order to determine their suitability and effectiveness in the event of the populace escaping the war on ''starships''. As the player character, you can locate and explore several of these vaults... most of which are abandoned, in ruins, littered with skeletal corpses and containing plenty of evidence to suggest that these experiments went very ''very'' badly wrong. Considering that the nature of most of these experiments took the form of sadistic and largely pointless psychological torture, [[ForegoneConclusion this is not entirely surprising]]. And then there's the ones that had GoneHorriblyRight instead...
* ''VideoGame/StarControlII'' has several examples: first, the Slylandro Probes. The Slylandro meant to program the Probes to go out and make contact with other alien species, and in the meantime, self-replicate using nearby raw materials. They accidentally set the priority for "self-replicate" above "make contact", unfortunately, meaning that the Probes see ''everything'' as raw materials to be used in self-replicating (the Slylandro are horrified when they learn of this). The other example is the Mycon, a race of sentient fungi engineered by the {{Precursors}} as a terraforming system... that, due to several millenia of being left to its own devices with no input, now terraforms in reverse, seeking out fertile, beautiful planets and turning them into hellish firestorms in which to make more Mycon.
* The Xel'Naga of ''VideoGame/{{Starcraft}}'' made the Protoss and the Zerg to make the next generation of Xel'Naga. The Protoss attacked them after they realized that the Protoss were diverging from the plan due to them revealing themselves, while the Zerg killed and ate them due to sabotage from a third party known as The Dark Voice.
* ''VideoGame/{{Portal 2}}'' halfway through the game introduces the origins of [=GLaDOS=] and how she became the overhead of Aperture Science. [[spoiler: Cave Johnson had his secretary, Caroline, be uploaded to a computer should he die before he could be uploaded. Caroline didn't want this at all, but she was forced against her will and essentially became immortal and stuck running the facility forever as [=GLaDOS=]. She then proceeded to kill all the scientists that tried to control her and make test chambers full of death traps.]]
* ''[[VideoGame/{{X}} X-Universe]]'':
** This is the plot-triggering event of ''[[VideoGame/{{X}} X: Beyond the Frontier]]''. Your character is a test pilot of a prototype jumpdrive-equipped starship, Earth's first attempt at FasterThanLightTravel in nearly eight centuries. During the jump test, the jumpdrive goes haywire and locks onto the method used by the ''previous'' attempt, in other words the X-Universe [[PortalNetwork jumpgate network]]. As the drive charges, you can hear the scientists yelling everything up to and including "Abort the jump test!" Then WHAM! Suddenly you're on the other side of the galaxy with most of your ship's systems shorted out, and to add insult to injury, within a few minutes, you're a few thousand credits in debt to the local ProudMerchantRace for making your ship able to fly again.
** According to the [[AllThereInTheManual backstory]] of the ''VideoGame/{{X}}-Universe'', this is how the Xenon came into existence. Originally, the Terraformer fleets were doing their jobs perfectly well and weren't a danger to anyone, then humanity gave them a software patch which turned out to be bugged ([[spoiler:or possibly sabotaged]]), and they immediately turned rogue and hostile, becoming the most dangerous force in the known universe. For added irony, the software patch that caused all this was meant to ''destroy'' the Terraformers; humanity had had an attack of [[GenreSavvy Genre Savviness]] and had realized just how bad things would be if the Terraformers ever went out of control, and wanted to get rid of them before that could happen.
* ''Concentration Room'' begins when a group of kids visiting their parents at a drug research facility are exposed to a botched batch of TruthSerum.
* ''VideoGame/{{Halo 4}}''[='s=] ''Spartan Ops'' lampshades this, with two missions in Episode 5 set one after the other titled 'Nothing Can Go Wrong' and 'Everything Has Gone Wrong'.
* There's a sizeable one in the backstory of ''VisualNovel/HatofulBoyfriend''. [[spoiler: When humanity was devastated by a new flu strain and the population dropped by ''seventy percent in two years'', scientists unleashed a virus to annihilate the birds that spread the flu. This killed many birds, but it [[UpliftedAnimal uplifted the survivors]], who promptly started to fight humanity.]] The end result is that the world is run by birds and humans are a tiny minority living in caves, and there are ''still'' agitators on both sides.
* The portal that warps the LegionsOfHell into VideoGame/AvencastRiseOfTheMage was opened by an experiment in dimensional travel. [[spoiler:Subverted in that this was exactly the result intended by Meganteolis as a way to get back to the Kyranian relics and enslave [[DemonLordsAndArchdevils Morgath]].]]
* Pokémon villains usually run into this at some stage, though the crowner has to be in ''[[VideoGame/PokemonDiamondAndPearl Platinum]]'', wherein Cyrus's plans managed to [[spoiler:piss off this universe's equivalent of ''Satan'', who stopped the world-remaking process, dragged Cyrus into a twisted dimension, and almost flat-out destroyed the planet instead of remaking it.]]
** ''[[VideoGame/PokemonSunAndMoon Sun and Moon]]'' have their own version, in which it turns out that [[spoiler:fusing with an EldritchAbomination called ''Nihil Ego'' has serious consequences for a person's mental and physical health. Lusamine has to go to Kanto to try to get the remains of the neurotoxin it left behind out of her!]]
* In ''VisualNovel/FateStayNight'' the Heaven's Feel Ritual was created to produce wonders of magic for use by the three founding families. Due to the fact that it could only grant one wish every sixty years and required ''seven'' magi to power it, the collaborative effort of the families turned into the Holy Grail War where ''nobody'' got a wish. And this repeated for the next two centuries.
** The [[spoiler:corruption of the Grail]] also resulted from this when the Einzbern subverted the safety system of the Grail in a failed attempt to summon a god. This resulted [[spoiler:the Grail being changed to [[JackassGenie grant wishes only in the most destructive manner possible]] while also [[PhysicalGod creating a god]] of [[GodOfEvil evil]]]].
** And ''then'', it turned out [[Literature/FateStrangeFake a group of American mages]] copied the ritual ''imperfectly'' during the Third Holy Grail War and tried to implement it into early 21st century America. Since the original ritual was so complex and magnificent, lots of stuff just fell into the cracks, allowing for the summoning of homicidal {{Eldritch Abomination}}s as Servants, the complete loss of the Saber template, and the start of two entirely different, ''simultaneous'', Holy Grail Wars.
* In ''VideoGame/DarkSouls'', the first thing the Lords tried upon learning that the First Flame, the source of their power, was dying was to create a new Flame. The Witch of Izalith, the most learned in the ways of magic fires, attempted to do so. Well... she was successful in creating a new Flame, alright, but rather than a source of power and safety, it became known as the Flame of Chaos, corrupting anything it touched and giving birth to horrific demons. In ''VideoGame/DarkSouls2'', the creation of the Flame of Chaos is said to have been "the greatest sin ever committed", such that the Witch of Izalith's ''reincarnation'' willingly imprisoned and tortured herself for life in penance, despite not even having committed said sin in her own lifetime.
* ''VideoGame/FiveNightsAtFreddys4'': [[spoiler: Oh, hey, let's prank my little brother who is totally scared of these animatronics by shoving his head inside [=Fredbear=]'s mouth-- Oh, shit, it just [[AmbiguousSituation bit off part of\crushed his head]].]]
* On the path to ''VideoGame/{{Undertale}}'''s GoldenEnding, you investigate the "True Lab", and the experiment with [[OnlyMostlyDead fallen-down]] monsters to attempt to preserve their [=SOULs=] after death by injecting them with Determination extracted from captured human [=SOULs=]. The monsters ended up actually getting back up, and looked to be good as new -- technically a failure, but [[HopeSpot a happy outcome nonetheless]]. [[spoiler:Then they all started melting, and their bodies fused together into the terrifying Amalgamates.]] The experimenter's notes also mention the disappearance of one early and apparently unresponsive test subject, [[spoiler:known to the player as Flowey]].
* From ''VideoGame/{{Warframe}}'', everything [[spoiler: the Orokin Empire]] build ended up backfiring on them. This includes things they created to fix their previous messes. Let's see, in chronological order of project crashing down on them, how much of a staggering display of GenreBlindness they exhibited:
** The Sentient. Meant to colonize another star system, ended up TurnedAgainstTheirMasters.
** They created the [[TheVirus Infestation]] to fight against the Sentient. Unsurprisingly, they lost control.
** The Grineer genetically engineered SlaveRace, which so far has been working pretty well, ended up being conscripted to fight both Sentients and Infested, and were generally treated like dirt. It unsurprisingly ended up in a mutiny since now they were the ones with the guns.
** And the last nail in their coffin, [[spoiler: [[PlayerCharacter the Tenno]], child soldiers in]] PowerArmor, who ended up [[spoiler: turning against the Orokin by the [[MissionControl Lotus]], though they were also treated like dirt]], bringing down [[spoiler: the Orokin Empire for good.]]
* With ''VideoGame/PathOfExile'''s ''Fall of Oriath'' expansion, this roughly explains the nature of The Beast. [[spoiler: Created by Sin to stifle the Gods from terrorizing humanity, it was created without any ambition which was great for resisting their temptations]] until humans came along and provided that missing piece and then used it as a weapon to terrorize each other.
* At the end of ''VideoGame/{{Bayonetta 2}}''[='=]s prologue, the titular protagonist summons a massive demon to pull off a [[FinishingMove Climax attack]] against a boss angel, much like how most boss fights end in [[VideoGame/{{Bayonetta}} the first game]]. Unfortunately, about a second after the demon retreats into the portral it came from, it then pops back out and [[TurnedAgainstTheirMasters turns against Bayonetta and Jeanne]], knocking the latter's soul out of her body and ''[[DraggedOffToHell dragging said soul to Hell]]'' and turns into the actual endboss of the prologue. Afterwards, Bayonetta spends much of the game journeying to Infero in order to rescue Jeanne's soul.

[[folder:Web Comics]]
* Webcomic/TheGoodWitch: WhatCouldPossiblyGoWrong when you give magic powers to a trans girl who's bullied by apparently everyone in town? Her turning into a psychopath in a "magical girl inheritance" trope gone awry.
* Pretty much anytime Riff begins playing around with TimeTravel or [[AnotherDimension dimensional portals]] in ''Webcomic/SluggyFreelance'', things go horribly wrong ''fast''.
* Many of the spells Anne performs in ''Webcomic/TheWotch'' (There's a whole arc titled "Consequences".) Cassie too, even the most innocent situations seem to have these problems.
* ''Webcomic/ElGoonishShive'':
** [[BigBad Damien]] was created as an attempt to cheat a vague prophecy by fulfilling it in controlled circumstances -- presumably, no survivors.
** "''Every'' properly trained wizard [[NeverLiveItDown has heard]] of Abraham, the ''[[SorcerersApprenticePlot idiot apprentice]]'' who ''[[DidntThinkThisThrough recklessly]] enchanted'' a massive ''diamond'' instead of ''[[CutLexLuthorACheck selling it]]'' to pay someone more ''skilled'' to fix his cursed noble friend."
* Happens about as often as one would expect in ''Webcomic/GirlGenius'', given its mad science setting. Sometimes inverted, as some {{Mad Scientist}}s will have their plan to take over the world go horrible wrong, resulting in them becoming happy well-adjusted individuals that are content to be lab assistants.
* ''Webcomic/TheOrderOfTheStick'': [[spoiler: Turning Xykon into a lich went very [[GoneHorriblyRight too well]], but it ''was'' also partially done to give Redcloak some leverage on Xykon. That part of the plan... didn't work. At all well.]]
* ''Webcomic/{{Homestuck}}'': Jade gave John four {{Infinity Plus One Sword}}s attached to an Infinity Plus One Bunny for his birthday. She didn't count on it falling into the hands of [[OmnicidalManiac Jack Noir]], giving him the firepower to become TheStarscream and promptly [[OneManArmy tear their Sburb session to shreds]]. And that's just the beginning of what led to their game session becoming [[UnwinnableByMistake unwinnable]].
* In ''Webcomic/LuminaryChildren'', people tried to improve humanity by undoing mistakes in history with time travel. [[BadFuture It went terribly wrong.]]
* In ''WebComic/StandStillStaySilent'', attempts to find a cure or vaccine to the Rash have been this, with humanity only finding products that cause quite unpleasant side effects and even the solution found JustBeforeTheEnd [[spoiler:killing people despite curing the disease, and making them into murderous ghosts without the people using it noticing due to the lack of mages at the time]].

[[folder:Web Original]]
* Lots of ''Literature/WhateleyUniverse'' examples, but how about the Russian program to create a nanotechnology SuperSoldier? The ''best'' iteration had one functional survivor... who melted into goo a year later.
** Or how about the bioengineering mad scientist who was found on a personal military submarine... or, rather, the people searching that submarine found around a dozen or two protozoan monstrosities, and [[{{Squick}} no trace of the crew]].
* ''WebVideo/YuGiOhTheAbridgedSeries'': This is what happens when the main characters try to fix things. Also, the backstory is portrayed as this.
-->'''Shadi''': ''But then something go horribly wrong.''
* Lampshaded in ''Roleplay/MSFHighForum'', as Michelle quotes it word for word. "If I'm in hand-to-hand combat, things have gone horribly wrong."
* In Episode 666 of ''WebAnimation/BowsersKingdom'', [[VideoGame/SuperMarioRPG Geno]] believes that the Zombie Apocalypse occurred because of the [[Franchise/ResidentEvil Parasol Corporation's]] attempts to create an unbreakable umbrella.
* In ''WebAnimation/IfTheEmperorHadATextToSpeechDevice'', the Emperor considers the Imperium in its [[CrapsackWorld current state]] this trope writ large. He believes that Malcador's Marines Errant turning into the Inquisition are also this. He's pretty much right.
* ''Literature/{{Starwalker}}'': The star step drive has the unfortunate consequence of [[spoiler: destroying stars and, by implication, entire systems.]]
* ''Website/TheOnion'': [[http://www.theonion.com/articles/what-kind-of-powdered-chocolate-drink-mix-have-we,11350/ What Kind Of Powdered Chocolate Drink Mix Have We Unleashed Upon The World?]]
* ''LetsPlay/UnoTheMovie'' is a LetsPlay by Creator/AchievementHunter with the idea of using the points system so that they would play to 500 points. It took nearly ''three hours'' to finish.
* In the sequel series to ''Literature/FearLoathingAndGumboOnTheCampaignTrailSeventyTwo'', an attempted American invasion of Cuba ends up a complete fiasco thanks to [[PresidentEvil President]] [[spoiler: Donald Rumsfeld]]'s insistence on hiring PrivateMilitaryContractors. Highlights include Special Forces remaining behind because their transports aren't insured by the Pentagon, a missile from an F-16 dropping like a lead weight and then ''locking onto the plane that fired it,'' body armor so worthless that soldiers just discard it in the middle of battle, a rifle that jams worse than the Vietnam-era M16, you name it. The situation is so bad that Soviet leader Nikolai Ryzhkov initially believes the intelligence reports to be propaganda by the KGB until it's confirmed by President Mitterand.

[[folder:Western Animation]]
* ''WesternAnimation/AdventureTime'' has Princess Bubblegum and her Frankenstein's Idiot, Lemongrab. She created him in her laboratory as the heir to the throne, in case something happened to her. Well... he didn't turn out as planned. Instead of a proper, reasonable heir, she ended up with a screaming, brain-damaged, mentally challenged sourpuss with a pathological obsession with sending people to the dungeon. She stuck him in a castle outside of the kingdom, but he came back when she was transformed into a child, as she was "too young" to rule the kingdom. He ended up screaming at everybody and sending all of the candy people to the dungeon for one million years. All of this because something went wrong with that life serum...
** Goliad is an even worse example. A candy sphinx created by Princess Bubblegum with her own DNA to lead the kingdom as an undying ruler to succeed her upon her death, she easily becomes corrupted due to following Finn and Jake's inept teachings in ruling. Without the timely intervention of the Princess's more successful experiment, Stormo (created from Finn's heroic DNA), she could have easily destroyed the entire kingdom with her psychic powers.
* ''WesternAnimation/AdventuresOfSonicTheHedgehog'': Dr. Robotnik planned for his CoDragons, Scratch and Grounder, to be [[HypercompetentSidekick hyper-competent]] {{Super Soldier}}s who could easily defeat Sonic. Instead, he got the exact opposite: two LethallyStupid clowns who Sonic regularly outsmarts and runs circles around.
* ''WesternAnimation/AmericanDad'' has "Project Daycare," an experiment mentioned in "Haylias" that had CIA agents put their children to undergo severe training and brainwashing to turn them into powerful [[ManchurianAgent sleeper agents]] that will be activated by a phrase only used by the parent; however, should the child remain activated for more than seven days, they'll immediately [[TurnedAgainstTheirMasters turn against their handler/parent and kill him]]. Unfortunately, Stan, who had subjected Hayley to this, was LockedOutOfTheLoop in regards to this and assumed that the project was discontinued simply because the children lost their free will permanently after seven days; he only finds out the truth ''after'' missing the deadline.
* ''WesternAnimation/BeastWars'', Scorponok hits Optimus Primal with a cyberbee designed to turn him into a coward. Unfortunately, Scorponok is an incompetent scientist and instead turns Optimus into a [[AxCrazy crazed berserker]] who, by the end of the episode, tears through the Pred base with ease.
** Rampage was an attempt to replicate the immortal spark of Starscream. While that part was successful, Rampage was also driven completely nuts. [[GoneHorriblyRight And almost unstoppable]]. He broke out, and brutalized, massacred, and ''ate'' his way through several Cybertronian colonies before he was finally stopped.
** An [[GoneHorriblyRight inversion]] when the Predacons infect Rhinox with a virus intended to make him into a Predacon (basically, it removed any inhibitions and gave him tons of ambition). Optimus, a good friend of Rhinox, immediately relizes what will happen and simply sits back to watch the fireworks. In a matter of days, Rhinox uses his genius-level intelligence and newfound ambition to subvert the Predacons from within and is an inch away from getting rid of Megatron. Luckily (for the ''Predacons''), the Maximals find him and turn him back.
* The underlying premise of the 90's cartoon ''WesternAnimation/ExoSquad'' was that, in an effort to terraform Mars and Venus, humanity genetically engineered a race called "Neo-sapiens" that were bigger, stronger, and more durable in pretty much every conceivable way... and used them as [[WeWillUseManualLaborInTheFuture slave labor]]. Nope, can't see any way ''that'' could go wrong.
** Luckily, they're sterile. And can collapse into a pile of mush. Yay, science.
* The Nanites in ''WesternAnimation/GeneratorRex'' were created to improve life on Earth and the human condition. Then something happened at the primary Nanite research facility that released a batch of Nanites with incomplete programming, infecting ''every living thing on Earth''. Now every living thing on Earth, from people to bunny rabbits, has a chance of spontaneously mutating into a horrible monster at any moment with little, if any, warning.
* ''WesternAnimation/JonnyQuest'' TOS episode "The Invisible Monster". Dr. Isaiah Norman's experiment gets away from him and creates a mass of energy that exists only to feed on other energy - including living things.
* ''WesternAnimation/ReBoot'': Wellman Matrix was just trying to find other systems and create a doorway to them through his experimental stargate. Unfortunately the targeting scanners locked onto Killobyte in the Super Computer and transported him to the stargate and overloaded it. This triggered a massive explosion that obliterated Mainframe's twin city and spawned Megabyte and Hexadecimal in the process.
* Dr. Weird from the openers of the first two seasons of ''WesternAnimation/AquaTeenHungerForce.''
* In ''WesternAnimation/TheTick'', a scientist tries to genetically engineer the perfect NonIronicClown. The only surviving hatchling (yes the clowns hatched from eggs) became the monstrous hulking superpowered Proto-Clown who quickly goes on a city wrecking rampage. He does manage to fulfill his intended purpose at the same time: his rubber nose's squeaking immediately makes people laugh. Unfortunately, the Proto-Clown ''[[BerserkButton hates]]'' it when people laugh at him. His city wrecking rampage was triggered by his creator laughing at him, and the attempted CooldownHug fails when his nose squeaks and everyone laughs.
* ''WesternAnimation/InvaderZim'' episode "Big Bad Rubber Piggy" has Zim try to use a time machine to erase Dib from existence. Because the time portal will only allow rubber piggies, Zim uses them to put past Dib in painful situations. Eventually, Dib becomes so physically malformed that Professor Membrane gives him an exoskeleton that grants him the power of "Ten THOUSAND LITTLE BOYS!!" The result is a super-strong and weaponized Dib rampaging through Zim's base, and each piggy sent in from there just makes Dib stronger.
* WesternAnimation/ErnestLeVampire: Simple household tasks would end this way, useually in "vacuum cleaning leads to the house burning down" kind of way, or a "picking up a can leads to the house collapsing" kind of way. Fortunately every episode was [[AllJustADream a nightmare]]
* In ''WesternAnimation/BatmanUnderTheRedHood'', Ra's al Ghul hires the Joker to ''distract'' Batman while he goes off to set up one of his usual plans to eradicate most of mankind. He didn't expect the clown to go and ''murder Robin''. It gets even worse when [[spoiler:he uses the Lazarus Pit to resurrect him, turning him into a man filled with a lot of pent up rage.]]
* ''WesternAnimation/WeBareBears'' plays this for laughs. Ice Bear's tinkering with robots has gotten his brother chased up a tree by a homicidal Roomba, and later resulted in a robot bear rampaging through San Francisco.
* In ''WesternAnimation/TransformersPrime'', Megatron views the revival of the Predacons as this when the powerful dragon Predacon he initially viewed as a success reveals [[spoiler:that he is sapient and can transform like any other Cybertronian. Megatron is especially disturbed when the Predacon names himself "Predaking" and asks that Megatron give him command over all of the other soon to be revived Predacons. Megatron wanted an army of mindless [[AttackAnimal Attack Animals]], not another potential [[TheStarscream Starscream]] (who unlike Starscream himself is fully capable of kicking Megatron's ass) with his own army.]] Megatron decides the risks are too great and has the project scrapped.
* ''WesternAnimation/StevenUniverse'': When (post SanitySlippage) Jasper is getting her butt kicked by [[spoiler: Smoky Quartz]] she attempts to get stronger by [[spoiler: Fusing with a Corrupted Gem. Unfortunately, it turns out that TheCorruption is contagious...]]
** As it turns out, ''the entirety of the Crystal Gem Rebellion'' was this. [[spoiler:[[WhiteSheep Pink Diamond]], hoping to save Earth and its inhabitants from the inevitable destruction of [[HostileTerraforming Gem colonization]], invented the persona of "Rose Quartz" and started a revolt against her own rule. Rather than accept the Rebellion as cause to abandon Earth, however, Pink's fellow Diamonds effectively told her to suck it up and take charge. Pink interpreted their words to mean that ''without'' her, the colonization would end, and [[FakingTheDead faked her death]] at the hands of Rose Quartz. Unfortunately, she drastically underestimated how much the Diamonds [[EvenEvilHasLovedOnes cared for one of their own]]: Blue, Yellow and White withdrew all Homeworld forces from Earth, but they also unleashed a FantasticNuke that inflicted a FateWorseThanDeath on every remaining gem as retribution.]]