->''"Biotechnology promises the greatest revolution in human history. By the end of this decade, it will have outdistanced atomic power and computers in its effect on our everyday lives."''
-->-- '''Introduction to''' ''Literature/JurassicPark''

Once upon a time, superheroes inevitably gained their superpowers from [[ILoveNuclearPower radiation]], the latest and most mysterious-yet-powerful fad of the 50s and 60s.

TechnologyMarchesOn, however, and gene splicing has replaced atom smashing as the most glamorous sciencey stuff: nowadays, many modern remakes of classic {{superhero}}es go with [[LegoGenetics Genetic Engineering]]. Be it a bite from a genetically engineered spider, or exposure to it in a freak accident, genetically engineered origins are the Phlebotinum for the 21st century. Rarely are the effects of "genetic engineering" anything like those portrayed in adventure fiction -- however, it's a buzzword that everyone knows, and that the average public knows just enough about for it to seem powerful, without any inconvenient actual education getting in the road of the Phlebotinum at work.

God only knows what superheroes will be getting their powers from twenty years from now - [[{{Nanomachines}} nanotechnology]], perhaps? (It's certainly very fashionable in CyberPunk these days.) [[QuantumMechanicsCanDoAnything Quantum mechanics]] is another good excuse - anything can happen [[Literature/{{Discworld}} because of quantum]].

Genetic Engineering also lends itself to being [[BiologicalWeaponsSolveEverything weaponized to do]] exactly the same thing as [[NeutronBomb those ultracool nukes that kill people but leave buildings standing]]. Now that nuclear apocalypse is substantially less likely (or at least less likely to [[ApocalypseHow wipe us all out]]), and Chemical/Biological weapons just aren't destructive enough in terms of human life, Genetic Weapons make a nice scary (and vague) alternative.

It's also interesting to note [[PhlebotinumDuJour the other favourite sources of weirdness]] used by SF writers before the advent of nuclear physics.

----
!!Examples:

[[foldercontrol]]

[[folder:Anime & Manga ]]
* The God Warriors from ''Manga/NausicaaOfTheValleyOfTheWind'' are both nuclear powered & genetically engineered, [[NinjaPirateRobotZombie in addition to being cyborgs]]. At least they were honest-to-goodness products of super-science, designed and built from the ground up to be what they were, not mooks with upgrades.
* The {{Super Soldier}}s in ''Franchise/LyricalNanoha''. Artifical Mages are genetically engineered so they will be born with full combat mage capabilities. [[HollywoodCyborg Combat Cyborgs]] are genetically engineered so they can be given cybernetic implants without their bodies rejecting the foreign object.
** The Ancient Kings of Belka qualified too. They altered their own genetics to transform themselves into [[PersonOfMassDestruction persons of mass destruction]] as part of a LensmanArmsRace, and they ensured that their descendants would [[SuperpowerfulGenetics inherit these abilities]].
* The girls of ''TokyoMewMew'' were "[[TheChosenOne chosen by the earth]]", i.e. born as perfect matches to various endangered animals. They were then injected with the DNA of said animals and became a squad of [[CatGirl kemonomimi]] {{Magical Girl}}s.
* Euphorics in ''SpeedGrapher'' gain super powers based on their fetishes after being carriers to a virus that is activated by contact with Kagura's bodily fluid.
* GuiltyCrown gives us the Void Genome, a genetic weapon that allows whosoever it's been implanted in the power to draw weapons known as Voids from anyone seventeen years of age or younger. These weapons can be [[{{BFS}} BFSs]] that can slice clean through HumongousMecha or ribbons of light than can repair anything (including ''a completely decimated bridge''.) Yes, it is a ''genetic'' weapon. And it winds up being implanted in an OrdinaryHighSchoolStudent [[PowersInTheFirstEpisode at the end of episode one.]]
* ''GundamSEED'' has the Coordinators, human beings whose genes have been improved prior to birth, resulting in a widespread increase in intelligence, talent, and physical aptitude. Unmodified humans are referred to as "Naturals", and there is significant tension (to put it mildly) between the two groups.
** Intresting enough, the Naturals tried destroying Coordinators with Nukes. It worked pretty well... Just not well enough.
* In ''Anime/PokemonTheFirstMovie'' a group of scientists funded by Team Rocket attempt to engineer "the ultimate Pokémon" by splicing genes from a Mew fossil. [[MemeticMutation And]] [[FamousLastWords they]] [[GoneHorriblyRight succeeded]].
* In the second season of ''BirdyTheMighty'' ''Decode'', [[spoiler: it's revealed that there exist [[OrganicTechnology spawning sacs]] left over from the days of TheEmpire which produce beings called Ixiora, which seem to be based on the HumanAlien Altan race. They possess extremely superior strength, durability, and, depending on the type of individual, various other incredible abilities. Whatever their original purpose was, the Federation government uses them for combat in a variety of capacities. Birdy herself is an Ixiora.]]
[[/folder]]

[[folder:Comic Books]]
* The ''ComicBook/ShamansTears'' comic introduced Bar Sinister (who later got their own short-lived series), a group of genetically engineered, super powered human/animal hybrids.
* In ComicBook/SonicTheHedgehog, it ends up the entire planet of {{Funny Animal}}s is the result of the alien species called the Xorda dropping a "gene bomb" on the planet, mutating it severely. Yes, the origin story for the heroes homeworld is that Earth was bombarded by genetic engineering weapons that caused fault lines to shift, seas to drain, and left the planet uninhabitable in many places for many years. Which is what you'd expect to happen if a planet got hit by several thousand multi-megaton nuclear weapons. In other words, in the Sonic universe genetic engineering ''is'' the new nuke.
** Knuckles the Echidna's origin has a combination of this and ILoveNuclearPower in the ArchieComics ''SonicTheHedgehog'' comics; his father, Locke, did genetic and radiation experiments on himself, then irradiated his son's egg with Chaos Energy from the Master Emerald.
* Taken to pretty literal extremes in ''Comicbook/{{Daredevil}}'', where the government's secret genetic experiment is ''named'' Nuke, to give an indication that, yeah, he ''was'' as deadly as a walking megaton bomb.
* Comicbook/UltimateMarvel takes this trope all the way, with genetic engineering being compared to nuclear weapons in other ways, such as international supersoldier escalation & treaties being proposed to curb it. Several Spider-Man rogues (as well as Spidey himself) were re-imagined to be the subjects of secret, illegal super soldier experiments, and other superheroes and villains were designed by secret government projects for the same end. [[spoiler: ''{{Ultimatum}}'' reveals that [[UltimateXMen this includes mutants]]]]. UltimateMarvel has even applied this trope to people who weren't even ostensibly super to begin with in regular Marvel. Ultimate IronMan's super genius is explained as the result of genetic experiments his parents were involved in (which resulted in his mother's tragic death) that resulted in him being born with braincells throughout his entire body. Unfortunately, due to a defect in the process it also gave him cancer and constant, agonizing pain.
** To quote NickFury: "The next war will be a genetic one."
** MarkMillar's big finale to the ''[[TheUltimates Ultimate Avengers]]'' took this to the logical extreme: with the team racing to stop radicalized countries like North Korea from getting their own superhumans.
* The Comicbook/{{X-Men}} have always been mutants, but interestingly, the earliest issues of the X-Men comics refer to them as "children of the atom" and say that Xavier is a mutant because of radiation his parents were exposed to before he was born. Current X-Men comics have abandoned the nuclear angle in favor of pure genetics, but all mutants are the end result of genetic engineering- by [[SufficientlyAdvancedAliens godlike aliens]] called the Celestials tens of thousands of years ago.
** The Celestials also created two other races by experimenting on humans- the ugly, shape-shifting Deviants, and their enemies, the PhysicalGod CanonSue race the Eternals, which after a bit of space-travel and civil war ended up founding a colony on Saturn's moon Titan, which eventually spawned {{Thanos}}, who conducted further genetic experiments on himself to make himself stronger. The Celestials split other alien races into Deviants and Eternals as well- the Skrulls are a race of Deviants who conquered their entire planet and built an interstellar empire.
** About the time the Celestials showed up on Marvel Earth, the Elder Gods had a similar idea and started making their own species, though these were engineered magically- [[MultipleHeadCase Set]] created [[ConanTheBarbarian the Serpent Men]], whilst [[OurAngelsAreDifferent Oshtur]] and [[GodOfEvil Chthon]] created numerous [[AlwaysLawfulGood good]] and [[AlwaysChaoticEvil evil]] races, respectively, with Chthon going out of his way to corrupt and re-engineer some of Oshtur's (or attempting to, with varying levels of success).
** A lot of improbable origins, including many of the 'radiation is magic' type, have been retconned as Celestial experiments resulting in people who would gain powers from things that would kill most people. Before this, it was often theorized by fans that maybe these people were mutants with a 'get powers instead of cancer from radiation[=/=]toxic waste' power, or latent mutations triggered by the FreakLabAccident; this seems to be AscendedFanon without making ''everybody'' an X-Man. Creator/DCComics has a "metagene" explanation that's similar. TheInhumans are a result of Kree experiments exploiting humanities' potential for superhuman abilities.
** ''Comicbook/SilentWar'' revolves around ComicBook/{{SHIELD}} getting a hold of the Terrigen Mist and trying to create its own [[TheInhumans Inhumans]] for military use. [[PowerIncontinence It doesn't work out so well]].
* Similar to the above, Franchise/SpiderMan's origins have moved from being bit by a radioactive spider in the original to being bit by a genetically enhanced "super spider" in [[TheSpectacularSpiderMan Spectacular]], [[Comicbook/UltimateSpiderMan Ultimate]], and both the [[Film/SpiderManTrilogy original movie]] and the [[Film/TheAmazingSpiderMan the reboot]]. 90's [[SpiderManTheAnimatedSeries Spider-Man show]] actually went half way, being bit by a spider that was hit by "neogenic" radiation. The mainstream comics eventually decided to hint that his powers might actually be magic, which to be fair makes more sense than radiation.
* In ''ComicBook/{{Watchmen}}'', [[FanNickname Squid]] is a genetically engineered monster whose effect visually strongly resembles a nuclear attack, making it both a figurative and an almost literal example of GeneticEngineeringIsTheNewNuke.
** Although the "nuclear" flash has nothing to do with genetic engineering and is in fact a result of the unstable teleport processes used to transport it.
* In a general sense, superheroes that would have been, and [[{{Retcon}} in some]] [[AlternateUniverse cases were]], created by [[ILoveNuclearPower radiation accidents]] in the SilverAge are now created by genetic accidents.
[[/folder]]

[[folder:Film]]
* Biollante from ''Film/GodzillaVsBiollante''.
** Also the Anti-Nuclear Energy Bacteria made from G-Cells that ironically is used to stop Godzilla. Still other nations see it as a huge threat that could upset the balance of power since it could render nuclear weapons redundant despite Japan making it clear they only wanna use it on Godzilla. In fact several contraries try to steal it and one agent is sent to kill the only man who knows how to make it.
* The 2002-2007 ''Film/{{Spider-Man}}'' movies. The [[Film/TheAmazingSpiderMan reboot franchise]] plays with it by having the spider be ''both'' radioactive and genetically engineered.
--> ''Is he strong? Listen here/He's genetically engineered.''
** Applied to the ''ComicBook/UltimateSpiderMan'' incarnation. Ultimate Nick Fury can even often be found reciting the trope.
* The Ang Lee ''Film/{{Hulk}}'' movie. Bruce gets his power from a combination of genetic engineering, pharmaceutical drug testing, nanomachines, and radiation. It seems the scriptwriters just figured that ''one'' of those was bound to work. [[Film/TheIncredibleHulk The new one]] fixed it to being genetic engineering jumped started with radiation.
** In the 2008 movie Bruce's research was specifically to recreate the super soldier serum, playing this trope as straight as possible since the original comic origin has Bruce developing a nuclear bomb using gamma radiation for the military.
* Any modern remake of a [[LongRunner long-lived]] superhero is doing this.
* In the original ''PlanetOfTheApes'' movies the apes simply [[HollywoodEvolution "evolved"]] greater intelligence. In the remakes, they're genetically engineered.
** Also, in ''RiseOfThePlanetOfTheApes'', [[spoiler:it appears mankind will be wiped out by the genetically-engineered virus which gives the apes intelligence instead of the nuclear war from the original.]]
* ''Film/TheIslandOfDoctorMoreau'' is a prime example: In the [[Literature/TheIslandOfDoctorMoreau 1896 science fiction novel]] by H. G. Wells, Moreau [[HumanityEnsues transforms animals]] on his island into PettingZooPeople called the Beast Folk and gives them intelligence, by a gruesome prolonged surgical vivisection process that is left deliberately vague, because the author wanted among other things to make a point against animal vivisection, common during his time, so the "how" wasn't the point of the novel. In the 1996 movie remake, set in 2010 and starring Marlon Brando and Val Kilmer, however, Moreau uses genetic engineering to create transgenic human/animal hybrids, some of whom look almost perfectly human, while others are humanoid but covered in fur and have snouts, hooves, horns, fangs and claws; without regular injections of Moreau's [[AppliedPhlebotinum serum]], however, these creatures lose their intelligence and slowly regress to their animal forms.
[[/folder]]

[[folder:Literature]]
* The virus in the ''WildCards'' series.
* TheIronDream: While a worldwide nuclear war 1100 years in the past completely polluted Earth with radiation and turned most of mankind and the fauna into a race of mutant mongrels (and the BigBad faction using radiation to breed their different sorts of mooks), in the end mankind is saved by excessive usage of genetic engineering, which finally even replaces normal procreation.
* The Meliorare Society in Creator/AlanDeanFoster's ''HumanxCommonwealth'' series was a group of [[EvilutionaryBiologist rogue genetic engineers]] who attempted to "improve" humanity by [[LegoGenetics tinkering with the DNA]] of unborn children, hoping to create physical and [[PsychicPowers mental]] superhumans. Naturally, things didn't go as planned, and after some of their more grotesque results came to light, they were [[ZeroPercentApprovalRating outlawed]] and eventually hunted down. Their "experiments" were mainly destroyed or, where possible, surgically altered to remove their abnormalities. The fate of the few who are left over is a major plot point of the series, forming the origin story of Flinx as well as [[spoiler:Mahnami]].
* ''MaximumRide''- Max and her friends are all bird-human hybrids, complete with [[WingedHumanoid wings]]. The laboratory that created them specializes in animal-human hybrids. In the sister books, (When the Wind Blows and The Lake House) Max is even more bird-like, even to the point of laying eggs and aging faster.
* Parts of the StarWarsExpandedUniverse involve "Sith alchemy", which does [[AppliedPhlebotinum whatever the writers want it to do]]. In the JediAcademyTrilogy, Exar Kun spent the four thousand years since his death using it to breed monsters.
** Quick cloning. With [[TheThrawnTrilogy Spaarti cylinders]], humans could be safely grown in as little as a year without [[PowerNullifier ysalamiri]], and as little as a ''month'' with them. While they grew they received flash training, so it was possible to get an army in as little as two months. The HandOfThrawn duology has a clone who had a bit of Thrawn mixed into his learning matrix in the hopes of making a leader with Thrawn's ability and long-range thinking. In ''Literature/GalaxyOfFear'' there is a cloning method that works in ''hours'', but the results are too unstable to be particularly useful.
** In the XWingSeries, Evir Derricote created and tailored the Krytos Plague, a very nasty disease with several variants, each targeting a different related group of nonhumans. The Quarren strain spreading to Mon Calamari, the Bothan strain also devastating Wookiees, and so on. He was ordered to make it something that mutated very quickly to infect as many species as possible, but also to be sure that [[FantasticRacism it didn't infect humans]], and while he succeeded on both counts that high rate of mutation also meant that once it was released it became less lethal.
** ''Literature/GalaxyOfFear'' is kicked off by a MadScientist trying to create a creature that would be the "ultimate weapon"; first creating six projects, many of them [[PlayingWithSyringes biological]], then using them to make something with AllYourPowersCombined.
* Used in the Whitney A. Curtis novel ''Legacy of Cryptia'', in which it turns out that genetically engineered superwarriors doubled as living batteries for the weapons that devastated Wellia with all the force of nukes.
* ''Literature/TheMoreauFactor'' (note the title) by JackChalker.
* The whole point of ''OryxAndCrake''.
* The Shongili family in the {{Petaybee}} books.
* SergeyLukyanenko's ''{{Genome}}'' novel is all about how genetic engineering results in DesignerBabies that are specialized and conditioned to love their "chosen" profession. This ranges from simple mental modifications (e.g. police detectives have a hightened sense of logic and love for truth and law and are unable to form emotional attachments; {{High Class Call Girl}}s easily falling in love with their clients and cannot fall out of love until the client reciprocates) to physical ones (e.g. starship pilots have a well-developed cerebellum for balance and can shrug off a 30-foot fall; fighters can move in the blink of an eye and have extra arm joints; power plant specialists have radiation-proof skin and hair with the males able to [[{{Squick}} "suck in" their genitals]]).
* ''Literature/TheHungerGames'' have several weaponized creatures scattered around both the titular games and the Capitol; like ferocious wasps with hallucinogenic venom and wolf "Muttations" with the faces of dead children.
* ''TheHollows'' replaced the nuclear arms race with the genetic arms race as part of the backstory, which in Turn creates the virus which wipes out a big chunk of humanity allowing the loss of the {{Masquerade}}.
* ''Literature/VorkosiganSaga'':
** The Houses focused on medical issues on the lawless planet of Jackson's Whole occasionally dabble in this if they think there's profit to be had from it, including the creation of Sgt. Taura, a failed SuperSoldier project.
** Cetagandans are big on genetic engineering, working toward {{Transhumanism}} for their ruling caste, as well as various bioweapons.
* In Creator/TomKratman's ''Literature/{{Caliphate}}'', the virus being developed [[spoiler:by the eponymous Caliphate, for use against the rest of the world]] is 97% fatal, with it believed by the protagonists that the other three percent would be crippled even if they didn't die from the disease.
* Much of the conflict in ''Literature/HonorHarrington'' was driven by the, ahem, ''conflicting'' opinions about genetic engineering and its outcomes, including the [[EarthThatUsedToBeBetter Final War on Earth]], and plans [[spoiler:of the [[AncientConspiracy Mesan Alignment's]]]] for the galactic domination. Weber even [[WordOfGod went to record]] stating that the BiggerBad's position on {{transhumanism}} and genetic engineering is actually ''[[VillainHasAPoint correct]]'', but that they are antagonists because [[TheyCalledMeMad they're dicks about it]].
[[/folder]]

[[folder:Live Action TV]]
* New ''Series/DoctorWho'' has a tendency to use genetics and DNA as a sort of AppliedPhlebotinum, especially for the Daleks.
* ''DarkAngel'': The superhuman abilities of X5 supersoldiers and other Manticore transgenics are the result of mixing genetic material from various humans (generally people who were very strong, smart, or talented) and animals, with some serious tweaking, into DNA cocktails. Genetic engineering is also the explanation for their attractiveness (the ones that don't look half-man half-beast or covered in huge bumps).
* Used in ''Series/{{Heroes}}'', whereby the plot-arc of a world-changing nuclear bomb from the first season has been replaced with the plot-arc of a [[LegoGenetics gene-altering formula]] in the third season.
* In one episode of ''Series/StargateSG1'', the villain was messing around with genetic engineering. A similar experiment later turns up in ''Series/StargateAtlantis''.
** Somewhat subverted, though, as powers tend to come from characters being naturally or artificially evolved toward some post-human ideal that results in ascension. Rather than powers being some unique attribute, all characters tend to evolve in roughly the same way. Other "superpowers" are usually the result of alien technology that operates on unexplained principles or some vague appeal to quantum mechanics (which probably ties back into how near-ascended beings actually do what they do, anyway).
* In ''Franchise/StarTrek'', The Eugenics Wars (aprx. 1993-1996) were a series of wars caused by an attempt to improve humanity through selective breeding and genetic engineering. Records of the era are patchy, so exact causes are unknown, but in 1992 genetically [[BioAugmentation augmented]] SuperSoldier [[Film/StarTrekIITheWrathOfKhan Khan Noonien Singh]] gained control over more than half the Eastern hemisphere. The following year, over forty nations were overthrown by Augements, most of whom proceeded to enslave unaugmented humans to varying degrees. The subsequent wars nearly plunged the Earth into a second Dark Age and killed over 37 million.
** Genetic engineering was also a main cause of WorldWarIII (2026-2056), a genocidal conflict that killed 600 million, destroyed many of the planet's major cities and governments, and irradiated the atmosphere causing several nuclear winters. Recovery as a species was perhaps only possible through the help of the Vulcans, whom we made First Contact with in 2063, shortly after the official end of the war.
* In ''Series/StarTrekDeepSpaceNine'', the Founders, the DangerouslyGenreSavvy ruling caste of the Dominion, utilize bio/genetic engineering to create super soldiers and personal advisors.
** Once upon a time, a primate family hid a gravely injured Founder from pursuers. The Founder expressed its gratitude by promising that they will, one day, be transformed into a superior form and rule a vast galactic empire. The primate species is now known as the Vorta, advisers, scientists and policy makers of the Dominion.
** The Jem'Hadar, super soldiers of the Dominion, are noted to qualify at least dozens of recommendations of the EvilOverlordList in their biological design. They wear no helmets(1, 130), wear carapaces that have no semblance to Nazi uniforms(21, 130), have superior eye sight that makes them expert marksmen(4, 56), possess exceptional strength and hand-eye coordination(236) are asexual in design(33, 43, 51, 84, 153), gain sustenance from a single source the Founders have absolute control over and require nothing else to function(127, 200, fark-9), require no sleep or rest(172, fark-9), work for the pleasure of obeying the "order of things" imprinted in their instincts(44, 48, 94, fark-9), have no fear or qualms using human wave attacks for the "order of things"(75, 234), memorize the entire manual with eidetic memory(57), and finally, can camouflage themselves to match the surroundings(237). And that's just the "design" part, not including their equally DangerouslyGenreSavvy training.
*** Their design, summarized by Quark, is that "the Jem'Hadar don't eat, don't sleep and don't have sex."
* The conspiracy in ''Series/{{Utopia}}'' revolves around a genetically engineered two-part [[spoiler: SterilityPlague]].
[[/folder]]

[[folder:Tabletop Gaming]]
* ''TabletopGame/AfterTheBomb'' can be summarized by this trope, and this trope alone. It's a postapocalyptic setting brought about by genetic modification becoming so commonplace that everybody and their little kid could buy a kit from the store to do it, and the consequences of that coming back to bite everyone in the ass (a program to breed a better chicken accidentally produces theropod dinosaurs, for instance).
* Palladium's other game: TabletopGame/{{Splicers}} takes this further, with LaResistance employing living PoweredArmor and [[BeastOfBattle Beasts of Battle]] to fight a RobotWar.
* The D20Modern remake of ''TabletopGame/GammaWorld'' abandoned ILoveNuclearPower in favor of this; the Big BlastOut was a horrific spasm of genetic engineering and nanotechnology gone haywire that annihilated civilization and unleashed all manner of ghastly abominations, including giant snake/bears that are eternally, ravenously hungry, featureless shadow-skinned humanoids, and worse.
* While genetic engineering is mostly a low-level background affair in the ''{{BattleTech}}'' universe (sometimes offhandedly mentioned as having been used to adapt a particular plant or animal species to a new world, but even the Clans' warrior breeding program relies primarily on just old-fashioned eugenics), the recent ''Wars of Reaving'' sourcebook introduced DNA-targeted viruses capable of selectively infecting trueborn in general, particular bloodlines, and even specific ''individuals'' if desired as part of the arsenal of the renegade Clan scientist faction known as "the Society". (Of course, part of what made them effective in this case was that Society members had easy access to DNA samples of their intended targets courtesy of the scientist caste being charged with managing the breeding program just mentioned in the first place.)
[[/folder]]

[[folder:Video Games]]
* The twisted monstrosities of ''VideoGame/{{Fallout}}'', which in spite of being set in a 1950s-esque retro post-nuclear wasteland, the UniverseBible credits largely to a mutated bioweapon.
** According to one source, Deathclaws are the products of direct genetic engineering. This applies to a number of other (significantly less widespread) creatures as well, with more canonical certainty.
* According to the Pokédex, Mewtwo was genetically engineered to be the most powerful Franchise/{{Pokemon}} ''ever''. Unlike [[GameplayAndStorySegregation most of what the Pokédex says]], this was unmistakably true, at least in Generation I. Not only was the [[GameBreaker/{{Pokemon}} Psychic-type]] a total GameBreaker, but Mewtwo had ''the'' highest base stat total of all 150+1 {{mon}}s at the time. Later generations have introduced Pokémon that surpass the Genetic Pokémon, but Mewtwo is still one tough bastard.
** [[VideoGame/PokemonXAndY Mewtwo later]] [[TookALevelInBadass takes back his title]] as the world's strongest Pokemon with his [[SuperMode Mega Evolutions,]] which are stronger than ''[[PhysicalGod Arceus.]]''
** In ''VideoGame/PokemonBlackAndWhite'', this trope is also the method in which Genesect was created.
* The Trigen of ''FarCry''.
* The subjects of ''Les Enfants Terribles'' in ''VideoGame/MetalGearSolid'' and its sequels. They use the 'genetically engineered from before birth' ''and'' 'nanomachine enhanced' versions.
* ''VideoGame/{{Crusader}}'' implies that Silencers are genetically engineered living weapons, just one of many in the ClicheStorm.
* The premise of the ''VideoGame/{{Geneforge}}'' series was the creation and alteration of new life-forms with magic and 'essence'. Indeed, all of the game's plots consist of one side trying to keep irresponsible people from creating life and others trying to stop the other from hoarding their power. Two of the more obvious examples are massive, fast-breeding bugs that are equally likely to eat your crops and yourself, or canisters that make spellcasting part of your DNA.
* This is also the entire premise of ''GEM: Genetically Engineered Monsters''.
* ''VideoGame/{{BioShock|1}}'': all of your plasmids and power-ups have abilities that, even with the most advanced bioengineering in the world, would be physiologically if not ''physically'' impossible. One of the worst offenders is a tonic that alters the way your research camera behaves.
* The Zerg in {{Starcraft}}.
* In the ''Compilation of VideoGame/FinalFantasyVII'', genetic engineering in the form of the Jenova Project and its side-projects is responsible for producing Sephiroth, Genesis, Angeal, the Tsviets, and most of the series' other SuperSoldiers.
* [[Franchise/SonicTheHedgehog Shadow The Hedgehog]], the UltimateLifeForm. Envisioned as a great defender of the world, and this is indeed what he ultimately becomes in spite of [[VideoGame/SonicAdventure2 a]] [[RoaringRampageOfRevenge set]][[DisproportionateRetribution back]] after his creator went mad with grief over Maria's death, then [[VideoGame/SonicHeroes amnesia]], [[VideoGame/ShadowTheHedgehog and then discovering]] that one of the genetic templates for his creation was an EldritchAbomination. Shadow has gone on to destroy or take part in destroying a number of Eldritch Abominations and armies of MechaMooks. His prototype, the Biolizard, also counts.
* In ''{{Evolva}}'', your Genohunters will change their physical appearance (change colors, develop spikes or horns) based on the DNA (acquired from your enemies) they've used to mutate themselves.
* In ''VideoGame/{{Syndicate}} (2012)'', Eurocorp and Aspari use gene splicing in their Agents. One of the fruits of this is Agent Crane, who has an accelerated HealingFactor.
* ''VideoGame/ResidentEvil6'' has a literal example of this trope, with the BigBad [[spoiler: Carla Radames]] possessing airburst missiles filled with the [[TheVirus C-Virus]] in gas form, which she launches on the city of Tatchi in China to cause an instant ZombieApocalypse.
* The "Mutation!" table of ''VideoGame/BallsOfSteel'' is about a genetic experiment that has mutated into a deadly green BlobMonster.
* The titular Galerians in ''VideoGame/{{Galerians}}'' are a group of [[DesignerBaby genetically engineered]] superhumans designed to [[KillAndReplace supplant the human race]].
[[/folder]]

[[folder:Web Comics]]
* ''Webcomic/{{Freefall}}'' generally shows Florence treated with as much suspicion as [[AIIsACrapshoot robots]], the fact that she is a living thing only adds to their fears of unpredictability.
* In TheKennyChronicles one can guess why a bunch of pirates scientists would create the Tarnekis, though they probably didn't intend them to rebel and form a "nation" of ships on the Pacific.
* The Lycanthrope [[http://egscomics.com/?date=2002-03-17/ Project]] in ''Webcomic/ElGoonishShive''.
* ''Urgent Transformation Crisis'' uses this as the central plot element.
* The Krakow Studios comic ''{{Spinnerette}}'' lampshades and double-subverts it. The title character gains her powers from a FreakLabAccident involving a "genetic infusion chamber" used to study spider heredity. This occurs soon after the head researcher [[http://www.krakowstudios.com/spinnerette/archive.php?date=20100218 berates a reporter]] for suggesting such nonsense.
-->'''Dr. Lambha:''' "God damn you idiots in the media! I'm doing research on ''spider genetics'', and you infer that I'm going to cure fatness or turn people into spidermen! Do you understand nothing about science?"
** In-universe, this is known as the "Cherenkov-Kirby Reaction". It was being studied by Dr. Universe before he turned evil as a clean source of power.
* [[http://www.schlockmercenary.com/d/20000725.html Comes]] [[http://www.schlockmercenary.com/d/20000802.html up]] in ''Webcomic/SchlockMercenary'' (okay, maybe not as powerful as an actual nuke, but still).
* Chapter 2 of ''MushroomGo'' involves a piranha plant genetically engineered to be intelligent.
* All over the place in ''TheCyantianChronicles'', first the [[{{Precursors}} Rumuah]] created the [[PettingZooPeople immigrant Cyantians]], then the [[AbusivePrecursors Squids]] enslaved the Cyantians and augmented some as pit fighters, forming the first generation of Elites. Finally Exotica Genoworks has been creating new species of Cyantians ranging from skunks designed as air fresheners to psionic raccoons.
** And the WMD version as well when ED accidentally [[DepopulationBomb wiped out most of the fox species]] with a virus.
[[/folder]]

[[folder:Web Original]]
* Jobe, of the WhateleyUniverse, is one of the great genetic engineers of the planet, despite only being fourteen. He has a plan for taking a person and changing her into a perfect drow. He accidentally gets an injection of the serum and finds out it has GoneHorriblyRight.
* [[http://vimeo.com/32844733 The Gate]] (2011) is an 8 minute sci fi/ horror film about people being mutated by unregulated performance enhancing drugs bought online.
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[[folder:Western Animation]]
* ''WesternAnimation/BatmanBeyond'', one of the groups of villains were the Splicers, [[CaptainObvious they spliced animal DNA into their own.]] [[AnimalStereotypes Generally lizard or snake.]]
** However most of them rarely use them for fighting, just purely cosmetic. To them it is pretty much getting a Tattoo in today's time. Just as tattooing can have unwanted side effects [[note]]such as allergies and infection[[/note]], even ''with'' clean equipment, so splicing can have negative effects as well.[[note]]Increased aggression and impulsiveness are noted in one episode.[[/note]]
* Came up a few times in ''[[WesternAnimation/AdventuresOfTheGalaxyRangers Galaxy Rangers]]''. On the lighter side was a NoodleIncident with mutated, flying plants that smelled horribly when decomposing. "Marshmallow Trees" had the titular trees (genetically engineered crops) growing out of control and threatening to destroy a colony world. The darkest example is the [[SuperSoldier Supertrooper Project]].
* ''TheSpectacularSpiderMan'' uses this as the PhlebotinumDuJour, not only with Spider-Man's [[LegoGenetics genetically-altered]] spider-bite, but with Electro's [[PsychoElectro powers]], granted partly by genetically-altered, [[AppliedPhlebotinum phlebotinum-enhanced]] [[PsychoElectricEel electric eels]]. The Lizard too, is a result of Curt Connors [[ProfessorGuineaPig dosing himself]] with an [[LightningCanDoAnything electrically catalyzed]] formula containing genetically-modified lizard DNA. The big one, though, is many of Spidey's enemies- Rhino, Sandman, Kraven etc.- are the result of [[MegaCorp OsCorp]] experiments designed to create superhumans, some of whom were pitted against Spidey for the sole purpose of distracting him so that he is too busy dealing with them to worry about TheManBehindTheMan Tombstone and all the crime he is behind (other villains are tech based). The Green Goblin, likewise, got his powers from an experimental superhuman serum. The series was ScrewedByTheNetwork, but had it continued it would have adapted ''The Clone Saga'' which would have continued using this trope as a theme, with MadScientist Miles Warren already working on such stuff by the end of the second season.
* The 90s animated [[SpiderManTheAnimatedSeries Spider-Man]] series uses a weird mixture of this trope and [[ILoveNuclearPower its predecessor]]. Several of the heroes & villains in that series got their powers from the "Neogenic Recombinator", a device that used a controlled beam of radiation to rewrite a subject's genetic code, and "neogenics" was a new science that was being investigated by many parties.
** Almost invoked the trope by name when Landon claimed that metal was the way of the past, the material for the future being human flesh.
* Several of the monsters Godzilla, Jr. fights in ''WesternAnimation/GodzillaTheSeries'' are the result of genetic-altering, such as the DNA Mimic and the D.R.A.G.M.A.s.
* During his FreakLabAccident, ''WesternAnimation/DannyPhantom'' had his genetic makeup modified with with ectoplasm, thus making him half-ghost.
* ''{{WesternAnimation/Gargoyles}}'' has Anton Sevarius, a geneticist working for Xanatos (or whoever else is paying him at the moment), creating a genetics-altering compound that mutates Derek Maza and three other humans into Gargoyle-equivalents. The compound combines bat, big cat, and electric eel DNA, [[LegoGenetics among others]].
[[/folder]]

[[folder:Real Life]]
* While the summary of the topic is almost universally true (at least in human experience) there have been very recent success with ''gene therapy'' - a process where an engineered virus is used to inject DNA into a particular tissue to modify the function of that tissue in some slight, but predictable fashion. Gene therapy has been a "holy grail" of sorts in the medical/genetics world for the last couple of decades with little-to-no success to show for the time and effort. However, very recently there has been success in a specific instance, where the process has shown some success at reversing the effects of macular degeneration, a disease - usually in the elderly - that causes blindness. DNA is injected ''directly'' into the affected eye tissue with sequences that are designed to counter the effects of the degeneration, which is known to have some genetic components. The tissue accepts the new DNA and starts generating appropriate proteins to counter the degeneration. This is a well-known, well studied disease, with a very specific application of this treatment, but the literature has shown measurable, medically significant effect. It's not exactly super-powers, but ''is'' capable of modifying, however slightly, a very specific body tissue, in a very specific way, WITH SCIENCE!!
** A more general (that is, not focused on a single body part) application is the production of insulin from bacteria. We used to use pig or cow insulin, but they don't work quite as well for people, it's easier to retrieve from bacteria, and there is a chance of an allergic reaction to residual bits of pig or cow.
* Technically, a genetically engineered super power could be more probable than a random mutation by radiation. With radiation, even if you do somehow get a beneficial mutation (and this is incredibly improbable, mind you), ''you'll still get radiation poisoning and die.'' GE is at least purposefully done with an aim in mind, instead of just randomly damaging bits of the genome in the event of radiation exposure.
* Genetic engineering, when applied to animals, can create blind or abnormally smart mice. Or mice that are always very hungry. Or cats with coats that glow under black lights. Still a far cry from superpowers.
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