[[quoteright:150:[[ComicBook/{{Pouvoirpoint}} http://static.tvtropes.org/pmwiki/pub/images/pouvoirpoint_fantastic_drug_0.png]]]]
[[caption-width-right:200: PXL : the more you're high, the more you're pixellated...]]

->''"People dance all day long if they take the stuff? What a weird drug."''
-->-- '''Shunsaku Ban''', ''Manga/AstroBoy''

If you need an addictive or psychedelic substance for a storyline, there's always one old standby: Make one up. This meshes perfectly with SpeculativeFiction, but would seem completely out of place in a realistic series. Alternatively, if it's a comedy, you could get away with ICantBelieveItsNotHeroin instead. Otherwise you can resort to the potentially {{narm}}y GRatedDrug.

Aside from a writer's hesitancy to show a beloved character using drugs, {{Media Watchdog}}s often cracked down on ''any'' depiction of drugs (even if they were negative) for many years. Lately it's been reduced to "heavily sanctioned" at best, creating the unfortunate irony that incorrect portrayal of the effect of drugs has made audiences more liable to dismiss the true effects of drugs as propaganda.

In RealLife, these are known as "designer drugs", for people who want to get high without using technically illegal street drugs.

Often can be the SpiceOfLife. Not to be confused (usually) with PsychoSerum. AddictiveMagic is closely related. Compare AlienCatnip when a mundane substance proves a drug to aliens.


[[folder:Anime & Manga]]
* ''Anime/CodeGeass'' has Refrain, which causes the user to relive their fondest memories, making it especially popular among the downtrodden Japanese. It's also rather important to the plot in several places.
* ''Anime/SerialExperimentsLain'' has Accela, a powerful nanomachine-powered stimulant that causes [[CaffeineBulletTime Accela Bullet Time]], heightened senses, and delusional thoughts.
** It also seems to physically link the user into the Wired, and susceptible to its more esoteric phenomena.
* ''Anime/CowboyBebop'' has the Red Eye, a stimulant which is sprayed in the eye and grants incredibly fast reaction times and dissociation from reality.
* One episode of the classic ''Anime/AstroBoy'' has "Yellow Horse", an intravenous drug made from "Space Dust" that causes euphoria & compulsive dancing followed by horrible withdrawal pains. The gang that created it, the bizarre Phantom Club (a group of mostly space colonists dressed up in ridiculous ghost costumes), in typical over the top cartoon villain fashion, apparently intended to get the entire population of Earth addicted so they could take over the world.
* A wide variety of new drugs are available in the setting of ''Manga/{{Gunnm}}'' (AKA, ''Battle Angel Alita''), as is typical of futuristic dystopias.
* An episode of ''Manga/SilentMobius'' deals with a drug known as Dommel, which is a very powerful performance-enhancing drug… with a tendency to mutate its users into hideous monsters before dissolving into a puddle of goo. It's extracted from the body of an demon from another dimension.
* Similarly, ''VisualNovel/TogainuNoChi'' has Line, which increases strength and reduces sanity.
* The BigBad of the Fishman Island arc in ''Manga/OnePiece'' uses this, as does his crew. It's called Energy Steroid, and taking one pill doubles your strength… but also shortens your life. We see the full effects at the end where [[spoiler: they age from their prime to weak old men just hours after the battle.]]
** From the Punk Hazard arc, we also have [=NHC10=], a highly addictive stimulant drug. It can be used as medicine, but only selected doctors in selected countries are allowed to use it. It only takes a small daily amount of it to be addicted, and its short-time withdrawal symptoms are pain and increased aggression. It's dangerous to the point that the characters who were shown to be addicted to it were writhing on the ground in agony, before going completely apeshit and attacking Luffy. [[spoiler: Oh, and said addicted characters were kidnapped children who were experimented on by the BigBad of the arc.]]
* Kerasine, a drug whose symptoms change with the dosage but also make people highly susceptible to suggestion, was a major plot item in ''Manga/GunsmithCats''.
* ''Anime/DarkerThanBlack'' has a substance like this produced in the bodies of bees who have fed off flowers from [[EldritchLocation the Gate]].
* In ''Manga/BananaFish'', the [[spoiler:mysterious "banana fish" that everyone is searching for is actually a variant of LSD that can be used to brainwash someone into doing whatever you want.]]

[[folder:Comic Books]]
* ''ComicBook/{{Watchmen}}'' had "Katies" (from KT-28, possibly a derivative of Ketamine), a type of drug often used by the Top-Knot gangs. It should be noted that this was not so much about avoiding naming real life drugs, but establishing that culture was divergent in this reality given the influence of Dr. Manhattan. Ordinary drugs such as marijuana and cocaine are also mentioned.
* ''ComicBook/ElfQuest'' has "dreamberries".
** In the Russian version they're called "Drunkberries".
* The ''Franchise/{{Batman}}'' comics give us "Venom", a highly addictive "super-steroid" which gives the user incredible strength, alertness, and agility temporarily. When first introduced, Batman himself is using it as a way to cope with his imperfections. He soon realizes he's made a terrible mistake, and must endure a horrific withdrawal before returning to normal. But Venom is most famous as the power source of Batman's enemy Bane, who wears a tank full of the stuff with tubes hooked up to his veins, giving him a constant, steady dose of Venom. The result is that he's incredibly strong (so much so that he once broke Batman's back… he got better) but totally dependent on the stuff, and Azrael eventually beat him by cutting off his supply.
** The Joker uses a deadly poison called "Joker Venom" that literally makes its victims laugh to death. Maxie Zeus (during one of his periods of sanity) diluted it with ecstasy and sold it as a recreational drug called Chuckles.
** In ''WesternAnimation/BatmanBeyond'', Terry encounters a new recreational drug called "slappers", transdermal patches which grant super-strength and occasional fits of "roid rage". When Bruce identifies the main chemical as Venom, he immediately suspects Bane is behind it; the real villain turns out to be Bane's orderly, who dies during his battle with Batman after he falls onto a box of slappers, overtaxing his heart. Afterwards Terry manages to scare teens away from the drug with a very effective PublicServiceAnnouncement: showing them that Bane had been reduced to an extremely frail invalid who needed Venom just to stay alive after decades of using the stuff.
** One ''ComicBook/JusticeLeague'' arc mentioned that Scarecrow has also gotten in on the act, selling a recreational version of his fear-inducing gas; signs of addiction include compulsively scratching one's nape. The same arc suggested that Psycho-Pirate has also somehow made a drug that can induce ecstasy.
* Creator/{{Marvel}} has Mutant Growth Hormone, or MGH. It induces a temporary genetic shift in the user, giving them superpowers. It also fucks you up good.
* In ''Comicbook/JudgeDredd'', there is a drug to give immortality to humans made by killing and harvesting glands of a sentient alien race, the Stookies, that have heart attacks at the slightest things (similar to fainting goats). Naturally, stookie glanding is completely illegal and people who deal in it are dealt with in Dredd's normal manner (most of them wind up dead). So do most of the Stookies he's trying to save. Stookie glands are so addictive, that the symptoms of coming off them involves rapid ageing.
** Umpty is a candy which is simply so extremely delicious that anyone who eats it develops an instant psychological addiction to it and will do anything to gain more Umpty to eat.
* In ''Comicbook/TheFlash'' and ''ComicBook/TeenTitans'', one of Vandal Savage's businesses is selling Velocity-9, a drug that gives the users superspeed. And then they burn out and die.
* D.M.N. in the ''ComicBook/{{Superman}}'' titles is a drug that ''turns the user into a demon''. It was created by [[{{Satan}} Lord Satanus]].
* Adam Warren's ''ComicBook/DirtyPair'' universe has several fantastic drugs, this being the future filled with transhuman technology. Wardrugs are (possibly) implanted applicators that inject a tranquilizing cocktail into the blood after a serious injury. Kei gets her leg half blown off, and starts 'glanding' wardrugs immediately, which makes her pretty loopy. There is also a chemweapon called 'Proust-in-a-Can', which places the victim into a coma while they are locked into re-experiencing a distant memory.
* Since ''ComicBook/{{Transmetropolitan}}'' is basically the adventures of HunterSThompson TwentyMinutesIntoTheFuture, there are several "future drugs" that protagonist Spider Jerusalem ingests injects and generally crams into every orifice. As noted in the Quotes section, among these is Mechanics, a nanotech drug that slowly turns your body into a cyborg system that turns addiction into a protocol.
** When Spider moves into an apartment, he finds his ''appliances'' are drug addicts. Someone went to the trouble of developing a drug that an AI can have plugged into its mainframe. (Those CoolShades? The Maker was high at the time.)
* ''ComicBook/TheInvisibles'' has the "Key" series of drugs (Key 17, Key 23) that cause people to hallucinate and mistake words for the thing they describe. Having been told he was infected with a flesh-eating virus, someone is tortured by being shown a hand mirror with a post-it saying "diseased face"; a villain drops to her knees, sobbing with regret and begging forgiveness in front of a "world's greatest dad" mug; and one of the {{Big Bad}}s explodes when [[BANGFlagGun a flag-gun saying "Bang!"]] unfurls in front of him.
* [[ComicBook/{{Marvel 2099}} Marvel's 2099]] line of comics in the early-to-mid '90s had quite a few examples of this:
** Rapture was a legal designer drug developed by (and exclusive to) the Alchemax corporation that would be distributed to employees in order to keep them loyal to the company. A "very high-powered, mind-expanding hallucinogen," it causes the user to feel perfectly calm and collected… unless he tries to fight the drug's effects, in which case it causes him to hallucinate wildly, "seeing monsters everywhere." It also bonds with the user's DNA in short order, becoming so addictive "you need it the way you need air to breathe." Geneticist Miguel O'Hara, who would become the Spider-Man of 2099, was slipped the drug by his boss when Miguel tried to quit the company. He tried to rid his system of Rapture by rewriting his own genetic code using a stored file of his genome which he'd been using for experiments. Things didn't go as planned, and Miguel ended up with spidery traits in his DNA as a result.
** A similar drug, Rhapsody, was mentioned in an issue of X-Men 2099, in which it was revealed that the Synthia corporation secretly laced its food products with the drug, so that consumers would become addicted to eating Synthia food, at the expense of their health.
** Chameleon 2099 turned out to be a drug rather than a person, which not only manipulated a user's DNA, it allowed him to shapeshift (either partially or completely) into whatever animal happened to suit the user's mindset at the time of taking the drug. Users have been seen assuming the characteristics of animals like bulls, mice, felines, and dogs. It was an Alchemax-designed drug, but "unstable even by their standards" to the point that users often die painfully from the toll it takes on their systems.
** Chain is one of the most illegal of drugs in that era. In 2099 A.D. Genesis, it was revealed that the legislation on Chain had been upgraded from a "thirty-year stretch" (being physically aged by three decades) for possession to a "death penalty" for even having it on one's person. In his only appearance in the 2099 comics, the Daredevil of that era planted a dime bag of Chain on a drug dealer just to make sure the dealer never pushes drugs again. At the time, the dealer had been peddling a drug laced with "a rider chemical" that "causes communicable sterility". In short, Daredevil signed a drug dealer's death warrant for trying to "kill all birth in Downtown."
** Perhaps the most bizarre example was found in X-Nation #1. The main characters, a group of teenagers living at the Xavier Institute for Indigent Children, had slipped away to a bar and try a unique hallucinogen: milk. They attached diodes to their foreheads; drinking milk stimulated their brains into producing bizarre hallucinations. But as one of them insisted, "'s really good f'r your bones an' teeeeeth."
* A shot of "buz", from an early issue of ''ComicBook/CerebusTheAardvark'', is one hundred percent addictive and provides all the nutrition an adult needs in one day. A villain uses it to subjugate and rule his entire city.
* Taduki from the ''Allan Quartermain'' novels (see below) also features in ''ComicBook/TheLeagueOfExtraordinaryGentlemen'', in which it's a thinly disguised version of opium, and Allan is hooked on it. ''Comicbook/TheLeagueOfExtraordinaryGentlemen Century: 1969'' also has the drug of choice in [[TheSixties Swinging London]] as "Tadukic Acid" (or "taddies") instead of LSD.
* The ''ComicBook/TopTen'' universe has drugs that induce super speed and give hallucinations that other people can see.
* So numerous in ''Comicbook/AmericanFlagg'' that the ''Comic Book Drug Reference'' has [[http://politedissent.com/cbdr_d.html a separate appendix]] dedicated to fictional drugs appearing in the series.
* In the "Five Years Later" version of ''Comicbook/{{Legion of Super-heroes}}'', a character is revealed to be taking [=ProFem=], a drug that [[GenderBender turns men into women]], but the change is only maintained if the drug is taken regularly.
* The mutant celebrity team ComicBook/XStatix had several custom drugs that helped to support their ultra-self-destructive lifestyles. U-Go Girl, for instance, took at least two different stimulants to counteract the extreme fatigue that her powers caused her. There was also a drug that many on the team used to instantly purge themselves of alcohol so that they could go straight from parties to missions. It was implied that this latter drug had terrible effects with long-term use, but since the average lifespan of an X-Statix member was only a few years at best, nobody really worried about it.
* During Creator/GrantMorrison's run on ''New X-Men'', Xavier and his staff had to contend with Hypercortisone D (or "Kick"), a highly addictive stimulant that boosted mutant abilities. Emma Frost described the high as making one feel both "angelic and violently insane for five hours." [[spoiler:It was eventually revealed that Kick was actually small portions of the sentient microbial colony Sublime, and allowed Sublime to [[TheVirus influence or even control]] its users' actions.]]
* The magic potion in ''ComicBook/{{Asterix}}'' is mostly just SuperSerum, but is played like this in a few stories where it's funnier. For instance, the druid who gives it to the villagers is named Getafix, athletes at the Olympic Games are banned from taking it, and in one story it's explicitly and repeatedly referred to as 'the dope' by a Roman trying to steal it. The official site also implies that it has some mild psychological effects, basically inducing childlike thought in people who drink it--explaining Obelix's [[ChildhoodBrainDamage strange personality]] and why even the more shrewd Gauls really enjoy beating people up on potion.
* In a few issues of ''[[ComicBook/ArchieComicsSonicTheHedgehog Knuckles the Echidna]]'' a substance called Lemon Sundrop Dandelion was hidden in hot dogs at an amusement park. After eating the dog most characters would begin tripping balls, though Charmy's friend Mello died of an overdose and Charmy himself almost did as well.
* ''ComicBook/AllSuperheroesMustDie'' has 90s, which apparently causes people injected with it to explode after 90 seconds.
* In a March 2015 story arc, ComicBook/{{Flare}} encountered Darkdust, which apparently turns people into {{Eldritch Abomination}}s.
* ''ComicBook/{{Pouvoirpoint}}'': various drugs with psychedelic effects are inhaled using a narghile, including a narcotic from Venus called ''PXL'' (which literally [[{{Pixellation}} pixilates]] you), and ''Demoulax'', which plunges the main character into highly hallucinatory dreams.
** During New Year's Eve, pills called ''En-fêtes'' [[EverybodyMustGetStoned are available at the buffet]], producing mild effects on the speech bubbles spoken by the characters (one will have reversed text, another will have hairy speech bubbles...).

* In ''Fanfic/EmpathTheLuckiestSmurf'', smurfnip is treated the same as pot with the attendant MarijuanaIsLSD trope. A telltale way to know that someone is stoned on smurfnip is that the whites of their eyes turn green.
* In the ''Anime/HeatGuyJ'' {{Yaoi}} fanfic [[https://www.fanfiction.net/s/2718711/1/In-A-Different-Light "In a Different Light,"]] there are three such drugs mentioned. All are evidently connected with Rave culture. The first is a very addictive one called "Black Tab," which can lead to extreme suggestibility and/or hallucinations. The second is called "Celestial Blue," which appears to be some hybrid of MDMA and heroin in terms of its effects. The third is called "Virgin's Blood," which is stated to be a dilute form of MDMA dissolved in a red syrup containing various aphrodisiacs, and is often taken with other drugs (such as Celestial Blue) that [[TheLoinsSleepTonight inhibit sexual performance]].
* Diamond Eyes in ''FanFic/CapeAndCowl''.
* ''FanFic/FalloutEquestria'': Littlepip gets addicted to Mint-als, especially of the Party Time variety. By chapter 20, she gets over her addiction (unlike Pinkie Pie, who was also addicted to these), flushing down her remaining Party Time Mint-als (which were a lot, mind you) down the toilet.
* In the ''WesternAnimation/TeenTitans'' fic ''[[https://www.fanfiction.net/s/3362802/1/One-Thing-Leads-to-Another One Thing Leads to Another]]'', Beast boy and Raven discover during their first time that Raven's magic can create an empathic link between them during sex. It proves to be [[PowerPerversionPotential a wonderful experience]], but causes significant tension after the effects prove to be mildly addictive for Beast Boy. They agree to reserve it for special occasions.

[[folder:Film - Animated]]
* ''WesternAnimation/StrangeFrame: Love and Sax'' features a scene where protagonists Parker and Naia get high on a selection of futuristic designer drugs.
* ''WesternAnimation/WhereTheDeadGoToDie'': where in the second chapter of ''Liquid Memories'', that it happened of the unnamed protagonist is use the drug.
* In ''WesternAnimation/{{Nine}}'', BigGuy 8 is at one point seen holding a magnet over his head, making his eyes go all fuzzy in a DoesThisRemindYouOfAnything way; presumably it messes up the electronics in his head.
* The "So Beautiful, So Dangerous" segment of ''WesternAnimation/HeavyMetal'' shows two alien starship pilots getting wasted on a white powder they identify as "plutonium nyborg" and then flying home utterly stoned. "NOSEDIVE!"
* As with the book it was based off, ''Film/AScannerDarkly'' prominently features the use of Substance D.

[[folder:Film - Live Action]]
* ''Film/RoboCop2'' has "Nuke," which is "injected" via disposable eyedrop vials. There was pretty much a cult based around the drug.
* ''Film/AttackOfTheClones'' had death sticks, something which the writers of the Holonet News promo [[https://web.archive.org/web/20120512054854/http://www.holonetnews.com/49/life/13328_1.html had some fun with.]] The ExpandedUniverse featured harder drugs such as ryll and glitterstim (which was, incidentally, the "spice" that Han used to smuggle for Jabba the Hutt).
* In ''Film/RepoTheGeneticOpera''[=GeneCo=], the company that makes artificial organs and cosmetic surgery, also sells a highly addictive painkiller called Zydrate that is used in its surgeries. It comes in a little glass vial and glows blue. LovableRogue Graverobber sells black market Zydrate that he extracts from the brains of corpses.
* Played with in ''Film/{{Transformers}}'' when a police detective accuses Sam of partaking in "mojo", which he assumes is a designer drug. "Mojo" is the name of the family's chihuahua, and the drugs are said dog's painkillers.
* ''Film/HarleyDavidsonAndTheMarlboroMan'' has Crystal Dream "...what it is, you don't shoot it, you don't smoke it, you don't snort it. Apparently, you put it in your eyes, and it tells you lies."
* The main plot of ''Film/{{Dredd}}'' involves stopping the distribution of a new street drug called "Slo-Mo" which causes the user to [[SlowMotion experience time at a fraction of its normal speed]].
* ''Film/AClockworkOrange'' (film and book) features substances like "synthemesc" (presumably mescaline or a close analogue), "drencrom" (presumably adrenochrome) and "vellocet" (given the resemblance to "velocity", probably "speed"-like amphetamines), all normally mixed into milk (thus why it's called ""milk ''plus''", as in milk ''plus'' whatever you put in it.
* ''Film/MinorityReport'' has "neuroin," dispensed from futuristic inhalers.
* ''Film/{{Looper}}'' features an unnamed designer drug administered via eye drops. It appears to cause awful withdrawal symptoms.
* The Creator/DolphLundgren film ''Film/IComeInPeace'' features an alien drug "collector" who overdoses humans with stolen heroin so he can extract endorphins from them for sale off-world.
* Ed Nygma's invention, the "Mind Blender"… er, the Box from ''Film/BatmanForever'', which allows him to suck the neural energy of everybody watching TV with the thing. Taking hits from Nygma's machine is apparently quite addictive. The Riddler himself spends hours on a stylized throne shaped like "The Thinker", jittering like a coke fiend as he sucks up more energy.
* The hero of ''Film/{{Limitless}}'', a hapless writer with no initiative, receives a mysterious drug called NZT that turns him into a genius.
* In ''Film/XMenDaysOfFuturePast'', Xavier being dependent on his medicine, and suffering intense pain from his powers returning when he stops taking it, is about the closest a PG-13 film can come to depicting the effects of drug abuse and withdrawal.
* ''Film/{{Snowpiercer}}'' has Kronol, an industrial waste that two of the protagonists as well as some of the upper class rave about in a world where even cigarettes are extinct. [[spoiler:Because of its highly flammable properties, the stuff is also used to make a makeshift bomb]].
* Hypnocil is a dream suppressant from the ''Franchise/ANightmareOnElmStreet'' films. It's useful as a defense against Freddy's attacks, but is later shown to pose a serious risk of rendering patients comatose.

* In ''Literature/ABrothersPrice'', so-called "crib drugs" are used to keep men able and willing to have sex. One of those drugs is, apparently, called "Everlast". It is implied that making men last longer is not the only effect, though--they seem to also act as aphrodisiac.
* In ''Literature/DragonBones'', Muellen, the mother of the protagonist, is drugged most of the time. One of her favourites is "dreamroot", but she also has other plants in her garden. It's what happens when a botanist becomes severely depressed--she was a well-adjusted, but delicate soul in Ward's childhood. Then her abusive husband became too much to bear, and she started seeking solace in the psychoactive plants in her garden. She doesn't seem to be quite there even when she's not drugged, having effectively fled reality and turned herself into a full-time {{Cloudcuckoolander}}.
* Kef from ''Literature/AncillaryJustice''. It suppresses emotions, so people either take it in the mistaken belief they will become [[TheSpock transcendent beings of pure rationality and logic]] or they use it to dull emotional trauma. If used for the latter it can be incredibly habit forming and addictive.
* From the beginning, drugs figure among the limitations on Literature/{{Deryni}} powers in the works of Creator/KatherineKurtz:
** ''Merasha'' is a drug that severely disables Deryni, with nausea, dizziness, blackouts, and severely disorienting psychedelic effects on the brain that prevent the drugged person from concentrating (a requirement for the use of Deryni powers). In ordinary humans, it only produces a mild drowsiness. In earlier times, Deryni were exposed to it as part of their training; after the persecutions began, knowledge of it, like so much else, became fragmented and contradictory. It does appear quite frequently in ''The Deryni Chronicles'' and ''The Histories of King Kelson'', and arrangements are made to expose Kelson and Dhugal to it in a controlled setting so they can learn to recognize it and mitigate its effects.
** The climax of ''High Deryni'' involves the use of two such drugs, though they are not explicitly named. One is a ''very'' slow poison (said to take '''at least a day''' to kill) which also prevents Deryni from using their powers, and the other is an "antidote" which slows the initial symptoms of the first but hastens its end result
* In ''John Dies at the End'', the plot revolves around a mysterious drug called "Soy Sauce," which gives the user enhanced sensory perception, clairvoyance, and the ability to see monsters and dimensional portals.
* In the ''WheelOfTime'' series, male and female magic users (called channelers) find the very act of casting magic from the Source is very addictive. So much so that many channelers only use magic when necessary, since it is easy to "burn out", permanently severing your ability to do magic, if you try to pull in too much magic.
* The first book in the ''Space Cops'' series, "Mindblast", centered around the spread of Hyper 2, complete with full chemical name and a lengthy description of how the drug worked. Cue heartbreak when the heros discover that the man who created the drug wasn't some sleazy dealer, [[spoiler:he had been trying to research a cure for his mentally retarded daughter.]]
* ''Literature/TheBlackCompany'': Mushrooms growing on a golem's body have an euphoric effect. The consumers start singing or laughing for no reason, and stop feeling both tired and hungry.
-->'''Sleepy:''' This stuff could get addictive.
* In [[Literature/MatthewSwift The Minority Council]], Pixie Dust is a super-addictive drug that enhances the magical talent of the user ten fold. It's also [[spoiler: made out of the ashes of previous users, as prolonged use turns you into dust]].
* The ''Franchise/MassEffect'' ExpandedUniverse introduced red sand, implied to be cocaine that's been exposed to [[MinovskyPhysics element zero]] radiation. Gets the user high, and also lets them temporarily use a weakened form of biotic powers. It started popping up in the main game series soon afterward.
* ''Literature/ASongOfIceAndFire'' also features a handful of drugs
** ''Milk of the poppy''--basically opium, which is usually used to deal with pain, but can also get addictive. Gregor Clegane takes it to deal with his chronic headaches, and seems to guzzle it like water.
*** In "A Feast for Crows", this comes back to bite Clegane ''hard''. [[spoiler:His excessive use of the stuff has given him such a high tolerance for it that it's practically useless against the pain of a poisoned spear wound to his abdomen.]]
** ''Sourleaf''--a mild drug apparently similar to tobacco that, when chewed, stains the user's teeth bloody red.
** ''Shade of the evening''--a psychotropic drug used by warlocks. It turns the user's lips blue.
* ''Literature/PerdidoStreetStation'' probably had several, but the plot relevant one was Dreamshit. Which is made up of dreams made physical and sawdust. A dose knocks the user unconscious while they experience all the dreams (of all "genres") semi-simultaneously. It's very intense but the hangover doesn't last long.
* Soma in ''Literature/BraveNewWorld'' is the ideal recreational drug. There is a RealLife drug of the same name, but it's clearly not the same substance.
* ''Literature/AScannerDarkly'' had Substance-D, sometimes abbreviated as "D" or "Slow Death." It was a powerful hallucinogen with some schizophrenic side-effects.
* Another Creator/PhilipKDick novel, ''The Three Stigmata of Palmer Eldritch'' had Can-D, another hallucinogen. You might [[AuthorAppeal sense a theme…]]
* The third book of the ''Literature/{{Spaceforce}}'' series, ''Oblivion'', centres around a FantasticDrug of the same name. Oblivion induces a lucid dreaming state in users, allowing them to experience a fantasy scenario of their choice--innocent or less so. Unfortunately, it can also cause users to return to the dream state without warning and at random days or weeks later, often causing fatal accidents.
* The ''Literature/InDeath'' series has a lot, with names like Zoner (a marijuana FictionalCounterpart), and Zeus (a PCP analogue).
* The ''Literature/RedDwarf'' novels had "Bliss", a brown powder that literally made you believe you were God, could supposedly get you hooked just by looking at it & would cause the user to become suicidally depressed for decades after coming down, which is probably what made it so addictive. Also, Better than Life, which was a sort of LotusEaterMachine in the books rather than the more innocuous artificial reality video game of the TV series.
* The universe of ''[[Literature/TheShipWho The Ship Who Sang]]'' has several designer drugs, including Blissto and Seductron.
* Fictional drugs abound in ''Literature/NakedLunch'' by William Burroughs: Black Meat, Mugwump Juice, etc.
* AUM from the ''Literature/{{Illuminatus}}'' trilogy, alongside a whole pharmacy of real drugs.
* The novel of ''Film/{{Metropolis}}'' (and cut portions of the film) had Maohee, a hallucinogen that causes a large group to experience the visions of a single person ([[DrugsAreBad problems arise]] when a worker takes it). Drinking water erases any memory of the drug whatsoever.
* In one of Creator/AndreNorton's books, she described a drug called crax seed, apparently chewed like tobacco (there's a reference to someone having spit out a crax cud). While high on the stuff, you're lots faster, stronger, and smarter than normal. When you come down, you come down '''hard''': "What occurred to them later was not pretty at all."
* Creator/AlanDeanFoster created Bloodhype, which must have ''fantastic'' marketing to ever sell, given that ''one'' dose is addictive--and withdrawal is ''fatal''.
* ''Literature/{{Discworld}}'' novels have the troll drug Slab, which is ammonium chloride cut with radium and is a hallucinogen--but only if you're a troll. It also makes their brains melt.
** There's a long list of drugs in ''Discworld/TheTruth'', some of which are genuine street names for real drugs, some of which sound like they ''might'' be street names for real drugs, and a couple of which are established as variants on Slab in ''Discworld/{{Thud}}''. These variants include Scrape (called so because you ''scrape'' the remains of Slab you have and cook it with pigeon droppings and alcohol. Also, you're scraping the bottom of the barrel), and Slide, which seems to be an ersatz for crack and PCP.
** ''Discworld/{{Snuff}}'' introduces Crystal Slam, an even-worse narcotic that's implied to literally [[YourHeadASplode make trolls' heads explode]].
* The ''Literature/{{Lensman}}'' series had nitrolabe, thionite, bentlam, and hadive. However, opium and heroin were still in circulation.
** Most of the stuff listed is comparable to drugs on the streets today (bentlam is described in decent detail in ''Gray Lensman'' and comes off as pretty tame: basically snuff that conks you out). Then there's thionite: the big one, ''so'' dangerous that trafficking in it ''is a capital offense''. With thionite, the user experiences the illusion of the gratification of their every desire, however noble or base. The catch is that while the psychotropic effects are tolerance-inducing (and so incredibly addictive that the one-time user can be traumatised for months), the physiological effects are not--and eventually the increasing dose required by the addict to have the same psychological effect is lethal. Always. And the effective dose is ''tiny'': in ''First Lensman'', a single dose was described as several tiny granules in a nasal capsule.
* Subverted in ''Literature/HouseOfLeaves'', one of the writers/editors, Johnny Truant, of the story within a story claims in one of the footnotes/journal entries that [[spoiler:he visited an old friend, who was a doctor, on one of his journeys. During his visit Johnny told the doctor about night terrors and screaming in his sleep, the doctor gave him a "yellow pill". Afterwords the dreams stopped and slept more peacefully. It was suddenly revealed that the Journal entries were faked by Johnny to make himself believe that his life was better than it actually was in the duration of the writing, painfully subverting the trope.]]
* A full list of fictional drugs found in ''Franchise/{{Dune}}'' would take up most of this page. The most important one is Spice, aka Melange. Melange is is highly desired not for recreational purposes, but because of its geriatric (life-extending) properties, and its ability to trigger precognizance and other advanced mental abilities in specially-trained individuals. Because of this, and the fact that it cannot be artificially synthesized, the entire economy of the ''Dune'' universe is centered around it. WordOfGod is that it's also [[{{Aesoptinum}} an analogy for the importance of petrol/crude oil in the real world]].
* Creator/TamoraPierce likes to do this. In the Literature/TortallUniverse, there's "laugh powder" and "hotblood wine" and and "rainbow dream." Some or all of these are probably real drugs under fantasy names (poppy is also mentioned), but we'll never know.
* Pierce's other series, the ''Literature/CircleOfMagic'' books, has "dragonsalt" in ''Magic Steps''. It's so addictive that trading in it is a capital offense. It has extremely stimulating effects, which handily counteracts the lethargy caused by [[AntiMagic Unmagic]].
* In ''Literature/TheDresdenFiles'':
** The "[=ThreeEye=]" in the first book, which was supposed to give its users second sight. Harry was skeptical [[spoiler:until a junkie noticed a rather nasty psychic scar of his. Turns out it actually ''did'' work; it was a potion an EvilSorcerer was mass-producing after he realized it was addictive.]]
** [[KissOfTheVampire Red Court vampire saliva]] contains an addictive narcotic, which helps them keep control of their victims.
** The series also contains a MundaneFantastic[=/=]AlienCatnip drug: dew drop faeries ''looooove'' pizza. [[spoiler:Except Lacuna in ''Cold Days.'' She's a GranolaGirl.]]
* Getting more specific in the Franchise/StarWarsExpandedUniverse, mind-altering drugs are typically called [[http://starwars.wikia.com/wiki/Spice spice]] and many of them are actually mined. Confusingly, perfectly normal food additives are also called spice, and a lot of spices also have medical uses.
** Easy justification for the confusion: "spice" is a street name.
** Pure [[http://starwars.wikia.com/wiki/Glitterstim glitterstim]] is made by giant underground spiders, is activated by light, and grants temporary ability to read nonhostile minds, although it also brings paranoia and apparently can make people stupider--in the Literature/XWingSeries, a habitual glitbiter forgets that he's talking to Wedge Antilles via hologram and thinks he's under attack.
** [[http://starwars.wikia.com/wiki/Bota Bota]] is a MagicAntidote to, well, ''everything'', and when a Jedi accidentally injects herself with a recently-prepared sample she momentarily becomes one with the Force. She tries it again later and it works a second time, and it then preoccupies her thoughts and causes her to doubt and and struggle with herself until she overcomes it, gives the samples to a droid, and sends it off to give to the Jedi Masters, who presumably will know what to do with it. Years later Vader, having read the report, takes it along with something that would make the effects more permanent. It doesn't work too well. Apparently bota goes bad.
** ''The Essential Guide to Alien Species'' mentions that Arcona can become addicted to ''salt''. Yes, sodium chloride. It's a hallucinogen.
* In Creator/RogerZelazny and Creator/RobertSheckley's ''Literature/BringMeTheHeadOfPrinceCharming'' trilogy, demons, angels, witches, and other supernatural beings drink a substance called ichor in lieu of alcohol. Ichor is also shown to have a raft of other possible uses, most notably as a magical preservative. It is also implied that a number of the more esoteric alchemical ingredients can double as drugs, particularly "black hellebore," which is noted to both stunt your growth and give your hairy palms.
* The ''Literature/SprawlTrilogy'' from Creator/WilliamGibson has several. There are a wide variety of "derms" that can be stuck to the skin and several kinds of crystals that are ingested or inhaled.
** And in ''Literature/{{Neuromancer}}'' Case goes through several trying to find something that his augmented liver can't [[ImmuneToDrugs process]] (it's augmented to prevent him getting high). [[spoiler:And he actually ''found'' one: a drug so wild that his body can't figure out what to do with it, meaning Case undergoes one weird trip.]]
* ''Literature/{{Bordertown}}'' has a river (theMad River, aptly enough) of this stuff, which, oddly, produces edible fish which are a bit freaky but don't cause intoxication. There's also "dragon's milk", which is a drug for [[OurElvesAreBetter elves]] but just makes humans sick, and the drug in ''Finder'' which supposedly turns its users into elves… needless to say, it doesn't work.
* Creator/ZilphaKeatleySnyder's ''Literature/GreenSkyTrilogy'' had Wissenberries. Also known as Sacred Berries, or just Berries. A narcotic with both medicinal and recreational uses, the Kindar also used it as a means of social self-control, even giving it to kids to quiet them down in class (Snyder was a school teacher, and the use of pharmaceuticals to make kids quiet and obedient is OlderThanYouThink). Addicts were called "Berry-dreamers". Snyder never said that Berries caused the dreaded "wasting" disease, but she did say that people with the wasting tended to eat a lot of Berries, even when they won't eat anything else. If you were really hardcore you could try pavo-berries, which come from a "parasitic shrub" and will kill you sooner rather than later.
* In the ''TabletopGame/{{Warhammer 40000}}'' Ravenor series by Dan Abnett, where a large part of the plot involves a drugs ring investigation, mentions several fictional drugs such as lho (which is the 40k tobacco), obscura, lodestones and flects.
* Continuing the previous example, several of these substances such as obscura and lho are also mentioned elsewhere in the ''TabletopGame/{{Warhammer 40000}}'' canon, such as the ''Literature/GauntsGhosts'' series. Though they are fantastic drugs, their uses approximate that of opium and something between cannibus and tobacco, respectively.
** While Ravenor (mentioned above) depicts Lho akin to tobacco, descriptions of the effects of lho by other authors made it more similar to cannabis.
* ''Literature/TheNameOfTheWind'' by Patrick Rothfuss has Denner Resin, which acts like opium. Addicts can be spotted because of their very white smiles (and the fact that they will do ''anything'' to get their next fix). This becomes a significant plot point when [[spoiler: a local dragon finds a Denner Tree orchard, eats the trees, and becomes addicted. And then it runs out of trees…]]
* In ''[[Literature/EddieAndTheGangWithNoName The Seagulls Have Landed]]'' by Colin Bateman, one of these, called "Crush" becomes a critical plot point. A whole gang war is going on over the stuff.
* The Taduki herb is a hallucinogen in Creator/HRiderHaggard's later ''[[Literature/KingSolomonsMines Allan Quartermain]]'' novels, which the title character uses to go on vision quests.
* Onadyn in ''Literature/RedHanded'' by Gena Showalter. The drug was made for aliens who couldn't handle oxygen, but humans started using it to get high.
* The ''Literature/{{Nightside}}'' series is prone to blend this trope with a ShoutOut, featuring references to people who smoke [[Literature/TheWarOfTheWorlds Martian red weed]] or mainline [[Literature/TheStrangeCaseOfDrJekyllAndMrHyde some Hyde]] for kicks.
* Fisstech in ''Literature/TheWitcher'' series is, for all practical intents, cocaine.
* In ''Literature/TheHungerGames'' we have morphling, a futuristic drug with probably heroin-like effects due to its name being derived from morphine, another opiate. Psychotic ex-Tribute Johanna has an addiction to it.
* ''Literature/LabyrinthsOfEcho'' has a few, and established early on that people born in one world reacts abnormally on psychoactive substances of another. So while locals, along with children, guzzle their Soup of Rest for a little relaxation and daydreaming, while Sir Max was instantly on high to the giggling idiocy followed by a withdrawal "as if trying to GoingColdTurkey after several years of heroin addiction" despite the help of highly skilled healers. On the other hand, Kakhar's Balsam is a psychostimulant strong enough that locals don't let each other drive under it, even though their traffic is excruciatingly slow by our standards, while Max drinks it much like strong coffee, and suffers even less side-effects. Conversely, once he accidentally acquired pot from our world and gave it to his NighInvulnerable friend with steel self-control to "relax a little"--HilarityEnsues; he was berated for not having a clue after personal experience with such things.
* Lemon sap in Cherie Priest's ''Literature/ClockworkCentury'' universe. It's distilled from a DeadlyGas and is highly addictive. The worst part, however, is that extended consumption turns the user into a rotting, flesh-eating [[OurZombiesAreDifferent zombie]]. A ''zombie''.
* Blisterweed in Jane Yolen's ''Literature/PitDragonChronicles'' is normally dragon food. Humans occasionally smoke it, which causes aggression and (with prolonged use) distinctive stains.
* The wizard Aurelianus in Creator/TimPowers' ''Literature/TheDrawingOfTheDark'' smokes dried snakes cured with "herbs and spices". He claims the fumes are beneficial.
* ''Literature/DinnerAtDeviantsPalace'' by Creator/TimPowers features a drug with the street name "Blood" (it's a reddish-brown powder that makes people think of dried blood) that's reputed to give the user a sense of warmth, happiness, and freedom from care. [[spoiler:It turns out that one of the key ingredients is, in fact, human blood, harvested from the victims of a psychic vampire.]]
* ''Literature/AliceGirlFromTheFuture'' features a planet which is a slum, with no one caring about anything around them. Turns out a few years ago someone invented pills allowing time travel. Naturally, everyone spends as much time as possible reliving the best moments of his life. Future can be traveled to as well, but people are afraid to.
* ''Literature/TheButterflyKid'' gives us the "reality pill", a psychedelic which causes hallucinations that physically manifest. The alien invaders planned to use it to cause chaos. Unfortunately for them, our heroes are hippies who know how to handle their drugs…
* Mentioned in passing in the Claire Carmichael book ''Incognito'': kava is a drink which appears to be as popular as coffee or tea. [[http://en.wikipedia.org/wiki/Kava Kava]] is a real drug, though not particularly well-known outside the islands of the Pacific.
* In the ''Literature/StarCarrier'' series acetic acid (like in vinegar) has similar effects on the Agletsch as alcohol does on humans (the most common way of producing vinegar is to turn loose ''acetobacter'' on some diluted alcohol, so it's possible to see a correlation).
* The GovernmentDrugEnforcement regimen in the ''Literature/{{Matched}}'' trilogy includes the Green Tablet, whose calming sensation works something like [[Literature/BraveNewWorld Soma]]-Lite.
* The ''Literature/{{Thraxas}}'' books feature two of note--''thazis'', which seems to be roughly equivalent to cannabis, and ''dwa'', which seems to be the equivalent of heroin.
* The ''Literature/AnnoDracula'' universe has "drac", which is made of powdered vampire blood and temporarily gives humans vampire abilities.
* In Creator/MCAHogarth's ''Literature/{{Paradox}}'' series one of the few drugs the Alliance bans is "wet", so called because it liquifies the brain after two doses. And one of the cheaper ways of producing it is apparently [[spoiler: to crack open sentient crystals]].
* In ''Literature/{{Coda}}'', the Corp's music is this. You can even overdose on it if you're not careful.
* ''Literature/SnowCrash'''s titular drug is the center of its plot, and is unusual in that it's distributed both in real life and in virtual reality ("The Metaverse"). Its real life version is distributed in special timed delivery canisters with self-destruct mechanisms to avoid anyone getting their hands on a sample of it. This to hide that [[spoiler:it's in fact a meme virus laced with drugs like cocaine]].
* In ''Literature/{{Masques}}'', Aralorn at one point ingests a herb that numbs pain, but has the side-effect of making her inable to eat anything, and she has problems walking in a straight line, too. [[spoiler: Considering that her fingernails have been removed by a torturer, it's understandable that she's not worried about side-effects at the time.]]
* In ''Literature/{{Nightshifted}}'', there is a drug called "Luna Lobos", which is [[spoiler: water extracted from the footprint of a werewolf. Which is known to turn people into werewolves according to myth. It does so in the novel, too, that's why people feel so good after ingesting it; werewolves do have superior healing abilities.]]
* In ''Literature/RedMoonRising'', real blood is this to vampyres as it's highly addictive. Some vamps also use prescription blood thinners and coagulates to obtain a species-specific high.
* The ''Literature/HammersSlammers'' series has "stim cones" that are used to inject a variety of stimulants that keep people, such as the titular mercs, awake for long periods of time. In ''The Sharp End'' a team from the Slammers evaluates two drug cartels planning a GangWar that sell a stim called "Gauge", which also seems to be hallucinogenic when mixed with by-products of the refinement process, as potential clients. [[spoiler: The survey team has an attack of conscience when they see what the cartels have done to the planet where they grow the drug and try to manipulate them into wiping each other out. Until the government has enough and hires the company to finish them off.]]
* In ''Literature/AlienInASmallTown,'' kreg is an alien virus. The human body can fight off the infection, but the user experiences a hallucinogenic high until it does; and the user's body does not gain a lasting immunity, so subsequent use will give a longer and longer high until the user may eventually be trapped in a hallucinogenic state lasting for days.
* ''Literature/TheStormlightArchive'': The Alethi elite are afflicted with something called "the Thrill," a race-wide bloodlust that drives them to fight, contest, and conquer. Their BloodKnight nature (as well as the fact that every aspect of their culture revolves around war and combat in some way) makes a lot more sense when you keep in mind that many of them are ''literally'' addicted to killing, and have built their society and religion to justify it. For example, the Vorin religion teaches that the afterlife is one massive war to reclaim [[{{Heaven}} the Tranquiline Halls]], so soldiers are the most important occupation, and getting your own soldiers killed in pointless battles isn't seen as a big deal since it's important training for the afterlife.


[[folder:Live-Action TV]]
* The fictional blue meth from ''Series/BreakingBad''. It is actually possible to make blue meth using the method Walter used in the show, but in reality that kind of methamphetamine is [[http://breakingbad.wikia.com/wiki/Blue_Sky#Purity_and_chirality rather impure.]]
* In addition to the drugs mentioned under Literature, ''Series/RedDwarf'' the series also has several examples:
** Outrazone (prounced vaguely like "ultrazone" in a mock-Canadian accent) is a chemical gunk that is apparently marijuana for mechanoids.
** A second season episode mentions a powerful hallucinogenic mushroom species native to Titan (one of the moons of Saturn).
** Apparently, by the time before Arnold Rimmer caused Red Dwarf's fatal accident, humanity had learned to create a form of gin out of marijuana. They called it [[CaptainObvious Marijuana Gin]].
* In ''Series/{{Smallville}}'', red kryptonite is Clark's personal drug, having almost destroyed his life several times over.
* Shows up in ''Series/{{Battlestar Galactica|2003}}'', where Laura Roslin's use of the drug "chamalla" has elements of morphine, heroin and marijuana, including painful withdrawal, hallucinations, and its use as a painkiller rather than actually affecting the disease she's taking it for. Similarly, several of the pilots find themselves obligated to use "stims" (the all-purpose sci-fi version of amphetamine) to keep up with their round-the-clock responsibilities, and suffer severe physical and emotional damage as a result.
** There was also a plant on New Caprica that was made into cigarettes that was smoked by Adama and Roslin, among others. From the way the effects were described, and that they already had an equivalent plant to Earth tobacco, it was assumed by many to be some form of cannabis. (They also referred to it as New Caprica ''weed''!!)
* "Stims" were used before ''Galactica'', in ''Series/BabylonFive'', with similar realistic effect. The abusing character, Dr. Franklin (yes, a medical doctor), starts out simply using them as necessary to keep up with his work, then grows addicted, almost kills a patient, gets investigated by Security Chief Garibaldi (a recovering alcoholic who knows whereof he speaks), leaves his job, suffers withdrawal, and eventually almost dies in an attempt to "find himself."
** There's also "Dust", a substance that temporarily grants telepathy to "mundanes" (non-Telepaths); this is used to [[MindRape take somebody else's thoughts for a spin]]. G'Kar gets his hands on some and tries using it on Londo; he realized halfway through that this was wrong, and got enlightenment (probably by [[spoiler:the telepathic intervention of Kosh]]) in the process. He ends up writing a book, founding a religion, and [[spoiler:[[OddFriendship becoming friends]]--if [[VitriolicBestBuds vitriolic ones]]--with Londo]].
* Season 6 of ''Series/BuffyTheVampireSlayer'' focuses quite a bit on Willow's addiction to casting magic spells.
** Season 5 has vampires feeding on drug-using humans-including Buffy's boyfriend Riley. It may or may not be the Orpheus from ''Series/{{Angel}}''.
* ''Series/StarTrekTheNextGeneration'', "The Game". A really lame video game with the power to seduce the entire crew's brains, to the point of ''unthinking loyalty'' to the game's creators, leaving the CreatorsPet and some-girl-we've-never-seen-before to save the day.
** ''TNG'' also came up with synthehol, a {{justified|Trope}} version of this trope. It's a replacement for alcohol in beverages that can (apparently) be flushed from the system quite rapidly if you're called back to duty while in Ten Forward. The science book ''Life Signs: The Biology of Star Trek'' went so far as to figure a way how it could work: broken down by adrenaline when RedAlert sounds.
** In ''Series/StarTrekDeepSpaceNine'', the Jem'Hadar are addicted to the milky substance ketracel-white so much that they die without it.
*** It's not just an addictive drug, it's their only means of nourishment past puberty.
*** And note: This is an ''engineered'' dependency; ketracel-white, in addition to providing complete sustenance, also provides essential chemicals their bodies need for normal function. The Jem'Hadar were essentially genetically crafted by the Founders to be their vision of perfect soldiers; the dependency ensures absolute loyalty.
** ''Series/StarTrekEnterprise'' introduces trellium-D, a substance which is harmless to most humanoids but screws up the brains of Vulcans, making them uncontrollably emotional, paranoid, and violent. After being exposed to it once, T'Pol develops an addiction and starts injecting herself with small amounts of trellium so she can experiment with the emotions that it helps her unlock.
* In ''Series/TheSecretCircle'', The concoction Nick and Faye were taking in Episode 2. Magic itself could also count.
** "Medallion" introduces us to a magical "enhancer" called Devil's Spirit.
* In ''Series/TrueBlood'' (and the original books ''Literature/TheSookieStackhouseMysteries'') [[OurVampiresAreDifferent vampires' blood]], a.k.a. V-blood, V-juice, or V, is apparently more fun than every other recreational drug ever. It also increases the libido, the senses, and gives limited SuperStrength. It even has medicinal value for those who are wounded. Too bad vampires as a whole don't take kindly to the commoditization of their life essence.
** It also creates adverse withdrawal symptoms if one gets addicted. In ''TrueBlood'', Jason's went static, and he became more aggressive and desperate. It also gave him a boner from hell when he overdosed on it, and had to have the blood painfully removed from his penis.
** Don't forget that taking the stuff will create a mystical bond between the user and the vampire it came from, allowing them to feel each others emotions, making the user sexually attracted to the vampire in question, and at least to an extent allowing the vampire to keep track of the user, though the extent of how well this works is unclear.
* ''Series/{{Angel}}'' has Orpheus, a drug which vampires take by drinking the blood of a human who's injected it.
* Several episodes of ''Series/RobocopTheSeries''.
* ''{{Series/Lexx}}'' called its Fantastic Marijuana "gongslanger root".
* Vraxoin in the ''Series/DoctorWho'' story ''Nightmare of Eden''.
** One New Who episode dealing with a future Earth had drug-ified emotions. [[spoiler:The invention of a "Bliss" drug led to the collapse of civilization]], resulting in humanity being forced to live in [[FateWorseThanDeath horrible traffic]] for generations.
* In Creator/{{Syfy}}'s 2009 miniseries ''Series/{{Alice|2009}}'', Wonderland's economy runs on the sale of liquid emotions extracted from Oysters, or people from the human world.
* The Trolls of ''Series/TheTenthKingdom'' have "dwarf moss" that makes you see fairies. However, the real example is the Troll King's invisibility shoes, which give their wearer such a great sense of power that they become more and more obsessed with wearing them all the time. Even touching them seems to be enough to begin the process; as soon as Virginia does so, she hides them in her backpack, thinks of nothing else, and acts increasingly paranoid, even clutching the shoes like Linus's security blanket. This is [[LampshadeHanging lampshaded]] by Wolf (twice!) when he claims "magic is very nice, but it's very easy to get addicted", and later tells Virginia she is "hopelessly addicted to those shoes… and I'm not too far behind!" Whether this is meant to be a parody or an object lesson is never made clear, but it certainly plays out with extreme hilarity.
** Of course, there are literary antecedents for [[Literature/LordOfTheRings some sort of invisibility equipment acting as a drug]].
** A later example would be the scene in the Deadly Swamp, where Tony and Virginia eat the magic mushrooms, drink the swamp water, and sleep ([[GenreBlind after being explicitly told not to]]) and hallucinate a [[DreamSequence bizarre dream]]. The fact that Music/ProcolHarum's "Whiter Shade of Pale" plays throughout is of course only window dressing for setting the scene…
*** To [[{{Anvilicious}} hammer the point home]], the soundtrack piece which accompanies both this scene and parts of the magic shoe shenanigans is entitled "Addicted to Magic".
* ''Series/{{Farscape}}'' has "Distillate of Laka" which helps take the edge off of John's Aeryn issues… when he doubles the dose.
** There's also freslin, a form of Space Ecstasy, which turns out to be made by [[HumanResources "milking" the glands of sentient beings]].
* The {{Series/Dinosaurs}} had a drug special which Robbie, Earl, and Charlene became addicted to a plant that they never really named.
** Robbie also develops an addiction to "thornoids" when trying to develop his muscle mass, a small [[{{Jerkass}} annoying and insulting]] rodent covered in spikes that acts just like steroids when eaten.
* The survivors of the show {{Whoops}} found a mutated berry bush that make you high by smashing it on your forehead.
* Vampires' blood-drinking in ''Series/{{Being Human|UK}}'' is an addiction, not a biological necessity, and comes complete with painful withdrawal symptoms and a 12-step program (well, for a while anyway.)
* ''Series/{{Tracker}}'' had an Enixian who was making a drug that his species used as eyedrops into their highly sensitive eyes. It was destructive and often fatal to humans, which meant Cole and Mel had to put the producer out of business.
* Dealing in kassa, an addictive corn-like grain, is a major source of income for the Lucian Alliance in the Franchise/StargateVerse. Some of the SGC's military actions in the last couple seasons of ''Series/StargateSG1'' involved kassa interdiction.
** There's also the Blood of Sokar, a Goa'uld-developed hallucinogen used by Apophis to interrogate SG-1 in "The Devil You Know".
* ''Series/{{Grimm}}'' has Jay, a [[{{PettingZooPeople}} Wesen]] only drug described as a combination of Meth, Rat Poison, and Helium, though functionally it's basically Heroin. Nick has to hunt down and break up a drug ring dealing the stuff, made more difficult from the fact that, since it's lethal to normal humans, it's not on any official government lists.
* In ''Series/{{Continuum}}'' Retrevinol (or "Flash" in street slang) is a drug from the future originally used as an Alzheimer's treatment. It allows the user to vividly recall memories, but results in a dangerous sleepwalking effect as they get lost in their memory, not to mention addiction as they continue to pine for their brighter past.
* ''Series/InTheFlesh'' has a new drug just for zombies (or act and behave like people but without the need to drink or eat) and seems rather popular seeing as no other vices are available to them. The only person we see use one however ends up dead… well, more dead at any rate.
* BrassEye notoriously aired an episode on drugs which highlighted the danger of a new designer drug called "cake." This came in the form of a giant yellow pill, and potential effects included slowing down time so a second lasts an hour, a bloating condition known as "Czech neck" and, in one case, a girl who "cried all the water out of her body." What made this example particularly controversial was that several real-life celebrities were asked to give their opinions and one MP even asked a question about it in Parliament. Suffice it to say that he didn't see the funny side, and subsequent repeats of the episode include an apology.
* ''Series/AlmostHuman'', being a future crime drama, inevitably has these. Such as "deep", a drug made from a deep-sea plant that is heavily addictive and has a low lethal dose.
* In ''Series/{{Supernatural}}'' Sam Winchester becomes addicted to drinking demon blood. Crowley later becomes addicted to injecting human blood after human blood was injected in him to "cure a demon".
* ''Series/{{Defiance}}'' has "Blue Devil", a powerful stimulant developed by the Earth Republic during the war. One of the main ingredients is human epinephrine, when the synthetic kind became scarce some cooks started using obtaining it from natural sources.
* ''Series/{{The 100}}'' has "the Red", a synthetic drug developed by the Mountain Men to turn people into Reapers. It's so addictive that anyone injected with it becomes borderline feral and will do absolutely anything to get another dose, and if they go too long without dosing up the withdrawl symptoms will kill them.
* ''Series/OnceUponATime'' has Maleficent diluting Sleeping Curse poison with seawater and mushroom to create a sedative that "takes the edge off". Essentially, it's the fantasy medieval counterpart of heroin.
* NZT in ''Series/{{Limitless}}''. It allows people to retain and access every memory they have, make connections between abstract pieces of information, and calculate everything around them. Nobody, not even the FBI, know where the drug comes from or who is distributing it. Even government attempts to reverse engineer it have failed and caused the users to burn out and die. Main character Brian is the only known person who can use it without the potentially fatal side effects.
* ''Series/SpaceAboveAndBeyond'' has pylaphatamine, street name "Green Meanies". To normal humans the little green pills are just painkillers, but they're instantly addictive to [=InVitros=], tank-grown humans such as Col. [=McQueen=] and Cooper Hawkes. Used for a DrugsAreBad subplot in the late-series episode "R&R".

[[folder:Multiple Media]]
* The Piraka in ''Toys/{{Bionicle}}'' bribe Brutaka (who's a good guy suffering from a major CrisisOfFaith) into working for them by supplying him with Antidermis. This works as a sort of highly powerful steroid to his species… and is also the substance that (unknown to them) [[EnergyBeing makes up]] the [[BigBad Makuta]]. As long as he only received small doses of the stuff (which were separated from Makuta's mind), he got a [[AmplifierArtifact power boost]], but when he soaked up multiple ''full'' Makuta essences, [[ManySpiritsInsideOfOne they took control over his body]], seemingly permanently--but in return, [[PowersViaPossession made him infinitely more powerful]].

* ''Radio/{{Undone}}'' had a story arc about a whole range of bizarre designer drugs being smuggled between parallel worlds, all PlayedForLaughs.


[[folder:Tabletop Games]]
* Since the only law in the titular city of {{Mortasheen}} is "Chaos Reigns", then it should come as no surprise that a few of the game's {{Mons}} are made for producing these. Aside from [[http://www.bogleech.com/mortasheen/daemonut.htm the two]] [[http://www.bogleech.com/mortasheen/grimbrosia.htm plant based ones]], there's also the [[http://www.bogleech.com/mortasheen/crepusculent.htm Crepusclent]], which secretes psychotropic worms that give you ludicrously powerful PsychicPowers, but also [[HilarityEnsues causes very vivid hallucinations]]. There's also [[http://www.bogleech.com/mortasheen/jitter.htm Jitter]], who has tumorous drug-producing glands in its head, that make it "a viable alternative to the coffee machine". Unfortunately, due to these glands' they're pretty much all insane.
* ''TabletopGame/OverTheEdge'' has several imaginary designer drugs such as Slo Mo, which gives the impression that time has slowed down.
* ''TabletopGame/{{Warhammer 40000}}'' features 'combat drugs' as options on several units, sometimes taken voluntarily. In-universe, these are basically a mix of stimulants, painkillers, and more exotic chemicals intended to keep a soldier going for as long as possible before dying. Usually in a berserk rage (the most common name for drugs inducing this condition being "frenzon"). The Literature/CiaphasCain '''[[MemeticMutation Hero of the Imperium!!!]]''' novels mention the names of several drugs: 'slaught, psychon, blissout, and others.
** Some background materials imply that the Emperor's Children, a legion of the settings worst abusers of combat drugs, manufacture those drugs from the basic components from [[HumanResources broken down human bodies]].
** Combat drugs aside, there are several recreational drugs that exist in the background as well. The most ubiquitous being the narcotic lho-sticks, which are smoked like a cigarette and apparently an opiate. Others include obscura, gladstones, and grinweed. Another example that plays the trope much straighter is flects, which are warp-saturated bits of broken glass, "used" simply by looking into them; keep in mind that since they are tainted by the [[HyperspaceIsAScaryPlace warp]], flects are a much more insidious example than most others on this page…
** The urban gang-warfare spinoff game Necromunda allows outlaw gangs to buy and use a variety of exotic drugs, including the frenzy-inducing 'slaught, "spook", which confers minor psychic powers at the price of probable mental and spiritual damage, and the powerful Icrotic Slime, which is really a brain-eating alien parasite that induces euphoria and considerable physical enhancements in its host to discourage removal (the user or an associate has to remove it before it encysts and begins feeding.).
* Both ''[[TabletopGame/VampireTheMasquerade Vampire: The Masqueradee]]'' and TabletopGame/VampireTheRequiem go for vampire blood as a drug. Humans who take it can look forward to halted aging and a measure of supernatural power, but risk getting addicted and being "blood bound," entering a state where no matter how much they hate the vampire, they can't raise a hand to harm them.
** In various sourcebooks for ''TabletopGame/MageTheAscension'', there are examples of magically created drugs, from the enchanted tabs of LSD, to various [[MadScientist Progenitor]] created drugs that are intended to have effects ranging from making the user aware of all things within a set area, more likely to believe certain realities, or become completely incapable of feeling emotions. Of course, this being Mage, players are able to make any kind of magical fantasy drug they want. Crack that turns you into fire? Go for it! Mushrooms that makes any hallucinations real? Of course! Drugs that [[TVTropesWillRuinYourLife make you aware of how every action you take has been taken before]] and it's all been [[BreakingTheFourthWall codified by magical beings who observe you invisibly?]] Sure.
** Additionally, the blood of other supernatural creatures has various effects on vampires in ''TabletopGame/VampireTheMasquerade'': werewolf blood is analogous to PCP, for instance, while mage and fairy blood act as powerful hallucinogens.
** The ''Mythologies'' sourcebook for ''Requiem'' actually introduces a drug specifically for vampires--Solace. It's injected via the tongue, made partly from the blood of teenaged "cutters", and allows the vampire to temporarily feel like they're alive again. It's extremely addictive.
** A suggested plothook in ''TabletopGame/ChangelingTheLost'' is the discovery of a goblin fruit known as "bloodroot", which has vampire-only narcotic properties, and the potential havoc that can ensue as unscrupulous changelings begin messing with vampire society and vampires, in turn, discover there is a drug they can actually ''feel'' and come hunting for it in turn.
*** The "Rites of Spring" sourcebook for Changeling: The Lost also notes that a shot of Glamour (the "mana" of changelings) has the same general effects as Solace--it makes a vampire feel alive again.
** One running plot for the ''TabletopGame/{{Orpheus}}'' line involved "pigment," a special type of heroin created by exposure to ghostly matter. Those who overdosed on it became their own special type of ghost--a "Hue," which could use [[TheDarkSide Spite]] with reduced penalty.
* ''The Book of Vile Darkness'' for ''TabletopGame/DungeonsAndDragons'' lists several fantastic drugs along with game rules for them (presumably because it's a book about everything that [[DrugsAreBad is bad]]). One of the nastier examples is distilled pain, which, [[ExactlyWhatItSaysOnTheTin well]]. There are naturally rules for addiction, but fortunately you can always remove that if you have access to the right spell.
** Also, in the Known World/Mystara setting for D&D, there's an Alphatian drug called zzonga.
** Somewhere between FantasticDrug and ICantBelieveItsNotHeroin is Lurien Spring Cheese from the ''ForgottenRealms'', also known as Halfling Cheese, mind cheese, and cheeeese. To humans it's a rather unpleasant dairy product; to halflings it's the most powerful narcotic imaginable.
* ''TabletopGame/{{Exalted}}'' not only has fantastic drugs, it has fantastic ways to produce mundane drugs. Namely, the Beasts of Resplendent Liquid, immortal dinosaur-like beasts engineered in the First Age by a Twilight Caste bioengineer. They feed on pharmaceutically helpful plants and [[SolidGoldPoop ferment]] the plants into an associated medicine. The Guild, however, got their hands on the Beasts, and now mainly put them to work on poppy fields so they can corner the heroin market.
* The future world of ''TabletopGame/{{Shadowrun}}'' has come up with a ''lot'' of these. Perhaps the most interesting is "deepweed", an Awakened form of seaweed that causes you to astrally perceive when eaten… whether you want to or not. Then there's BTL (short for [[Series/RedDwarf "Better Than Life"]]) chips/programs, which come in varieties ranging from "pornography" to "emotional overload" to "deliberate synthesia".
* ''TabletopGame/UnknownArmies'' features the magical school of Narco-Alchemy, which allows an adept to apply the principles of alchemy to the drug trade. There's a ''lot'' of fantastic drugs involved.
* ''TabletopGame/EclipsePhase'' features a lot of drugs. Recreational drugs, combat drugs, social drugs, narcoalgorithms for cybershelled characters… but most notably nanodrugs that use NanoMachines to induce states that simple chemicals could never accomplish. For instance "petals" are a variety of nanite-infused flowers whose petals send the user into a very trippy virtual reality when consumed; one popular variety makes the user think his hand has detached itself and is running away.
* ''TabletopGame/GURPSTechnomancer'' has two magic-enhancing drugs. "Spelljack", which is powdered [[PowerCrystal powerstone]] mixed with cocaine, and PHTP, which is a treated version of the chemical that allows humans to control magic [[HumanResources harvested from the brains of mages]].
* ''TabletopGame/TranshumanSpace'' also has nanodrugs. Nanodrugs that affect someone's brain chemistry (including positive effects like increased mental stability or improved memory as well as hallucinogens and narcotics) are called brainbugs.
* ''TabletopGame/PsionicsTheNextStageInHumanEvolution'' has several drugs that unlock, supress, or otherwise affect psionic powers, in addition to several combat drugs that don't exist.
* ''TabletopGame/MyriadSong'' has several, many are lethal to species other than the one they're designed for, such as the [[SiliconBasedLife Towser]] drug Snowblind. And then there's Charas, produced by [[PlantAliens Morphir]] that have eaten brains and containing absorbed memories, occasionally smokers come off a trip with new skills.
* ''TabletopGame/HcSvntDracones'' features ordinary stims, which do everything from boosting reflexes to replacing sleep, and are inhaled and legal. And then there's Vitae, a miracle compound that keeps flesh alive and vital regardless of lapses in infrastructure (i.e. gaping holes in your body). Taking regular infusions of Vitae gives you a ton of energy and makes you immune to poisons and allows you to ignore a lot of damage, but unless you have a very expensive implant that's only available to loyal Progenitus employees and carefully regulates the Vitae that durability comes at the cost of your sanity. Unregulated Vitae users have a tendency towards [[http://hcsvntdracones-game.tumblr.com/post/104000215878/tti-and-progenitus-are-one-of-the-few-corporate horrific self-mutilation]].

[[folder:Video Games]]
* ''VideoGame/Sly2BandOfThieves'' has Spice, harvested from Indian flowers. In large amounts, it causes uncontrollable rage and hatred in the user, acting a little like [[GRatedDrug G-rated PCP]].
* The ''VideoGame/{{Fallout}}'' series features a wide array of drugs, from Mentats that boost your brainpower to Jet, a stimulant extracted from Brahmin manure with severe withdrawal symptoms. Also Buffout (short-term boost to physical strength and endurance) and Psycho (increased damage resistance). The player character can become addicted to any or all of them; certain traits taken at character creation can affect how effective and addictive they are.
** ''VideoGame/{{Fallout 3}}'' had to change the name of a drug morphine to 'Med-X' in order to keep distribution in certain countries. A cry against 'censorship' went out, but real life drug names were never part of the Fallout franchise before, and Bethesda pretty much designed them to act like magic potions anyway, and this one in particular doesn't realistically simulate morphine. Also, in Fallout 3, a Ghoul comes up with a way to come up with a drug that can actually affect his kind. Ghouls barely feel anything from Jet, so he cooks up a way to turn it into ''Ultra''jet. Put simply, Ultrajet has serious and potentially permanent consequences on a human.
** Some products were addictive in some but not all games they showed up in. Ordinary Nuka-Cola, for instance, was addictive in the first two games and ''Tactics'' but not in ''3'' or ''New Vegas'' (granted, it was a rather benign addiction--all withdrawal did was tell you you craved another Nuka-Cola--and there ''are'' several references and allusions to it in ''3''). The same is true for Radaway, though with a slightly harsher addiction and no mention at all in later games.
* ''Franchise/SilentHill'' has the hallucinogenic White Claudia/PTV.
* The plot of ''VideoGame/MaxPayne'' revolves around Valkyr, colloquially known as "V", a PCP-like drug [[spoiler:originally developed as a SuperSerum for the military, but abandoned when it turned out to be addictive PsychoSerum, spurring the manufacturer to recoup their losses by selling the stuff to the mob, who then turned it loose on the streets.]] V also appears to have hallucinogenic properties, sending the titular hero on a ''really'' bad trip when he gets forcibly dosed up with it at one point.
* ''VideoGame/DeusEx'' has Zyme, the drug of choice for teenage rebels and junkies in 2052, in game it just gives you the effect of at least a dozen bottles of alcohol (wobbly and blurry vision - although presumably the effect is more potent on normal humans who don't have nanoaugmentations to quickly flush the drug from their system) the Shifter game mod allows you to use it for temporary bullet time (normal effects still come after it).
** TheNamelessMod has Melk (TM), it has religious uses with the Goat cult, who have fountains of the stuff [[spoiler:that allow their high priest to resurrect herself everytime she is killed, until they are shut off]]
*** There is also crystal melk, which functions just like Zyme in the original game.
** ''VideoGame/DeusExInvisibleWar'' introduces Black Market Biomods, which have elements of this. They're illegal, and supposedly have negative effects on some people (forunately, your character is not one of those unlucky people). Complete with messages warning parents about the dangers. Plus, they're only sold by cyborgs in dark alleys.
* ''Franchise/TheElderScrolls'' series has Moon Sugar and its derivative Skooma, not to mention loads of fictional alcoholic drinks. Puts a whole new twist on the Alchemy skill.
** There are mods that allow you to produce Skooma out of raw Moon Sugar, which can then be sold for a decent profit to certain less than scrupulous traders.
** It should be noted that most honest merchants won't even barter anything with you if you have Skooma on you. You have to drop it first.
*** ''[[VideoGame/TheElderScrollsVSkyrim Skyrim]]'' adds Sleeping Tree Sap, an extract of a glowing tree that make you feel healthy but is a hallucinogenic that slows you down.
*** For a more complete list see [[http://elderscrolls.wikia.com/wiki/Narcotics here]]
* Black Lotus is mentioned in passing several times in ''VideoGame/BaldursGateII''--a backroom in the Cornet Inn suggest that it's an Opium Analog, and for a very mercantile city, Amn forbid the selling of it.
* In ''VideoGame/SaintsRow2'', the Sons of Samedi manufacture Loa Dust, which is popular amongst the potheads at college. Part of the Saints' campaign against the Sons is in figuring out how to make it themselves, then stealing the competition's market.
* [[ShoutOut Liquid Sky]] in ''VisualNovel/{{Snatcher}}'', which was necessary since the game was made right in the middle of the 'War on Drugs' campaign.
** And Narc from ''VisualNovel/{{Policenauts}}'', which gave a shout out to the use of Liquid Sky in ''Snatcher'' by complaining that the two places with the highest drug rates in the populated world are Beyond Coast and "America, where the War on Drugs is still being fought".
** Narc is described as having 'the addictiveness of heroin and the hallucinogenic effects and potency of LSD'. Presumably it also gives you the ''high'' of heroin, because, otherwise, what'd be the point when you could take normal, non-addictive LSD?
*** One character in ''Policenauts'' has the ability to not even respond physically to being shot due to the anaesthetic effects of Narc, and the main ingredient is from poppies, so it's presumably more opiate than hallucinogen.
* Nekoko's fairy dust in Yume Miru Kusuri.
* Instead of the benign {{Mana}} potions [[StandardRPGItems found in other games,]] ''Franchise/DragonAge'' features lyrium, an addictive mineral that can either be inhaled as a powder or made into elixirs. Side effects include delusions, paranoia, dementia, obsessive behavior, hallucinations, [[ArsonMurderAndJaywalking dry mouth…]] higher doses or exposure to large amounts of naturally occurring lyrium can cause overdose-like symptoms along the lines of brain damage and death.
** The [[ArtifactOfDoom pure lyrium idol]] in ''VideoGame/DragonAgeII'' is responsible [[spoiler:for Bartrand and Meredith both going insane. The latter is a Templar, and thus ''already'' reliant on lyrium to power her anti-magic abilities.]]
** Offhandedly mentioned is Aquae Lucidius, a liquor whose ingredients include ''wyvern poison''. It's apparently popular among [[DeadlyDecadentCourt Orlesian nobility]] (including the Empress herself). According to Tallis, it'll make you see [[PinkElephants purple dragons]] for days. The codex entry has these testimonies:
-->"I feel confused but happy!"\\
"It was as though my soul took wing and floated about my head."\\
"I had a vision of my great-grandmother and found it oddly arousing."\\
"[[ShoutOut I can see through time!]]"
* The nastier effects of lyrium usage are shown in even greater degree in ''Videogame/DragonAgeInquisition''. Cullen struggles throughout the game with lyrium withdrawal, since he stopped taking lyrium after leaving the Order. He also tries to discourage a Warrior Inquisitor from becoming a Templar since that means taking lyrium. And that's not getting into Red Lyrium, a far more potent variety [[spoiler:which was used in the above-mentioned idol's creation.]] As Varric puts it red lyrium is lyrium like a dragon is a lizard. Regular lyrium is only dangerous if it's ingested. Just being near red lyrium is dangerous enough, let alone consuming it. [[spoiler:Red lyrium is normal lyrium tainted by the Blight… which means that lyrium is technically alive, since minerals aren't affected by the Blight.]]
* ''VideoGame/{{Haze}}'' has Nectar, which makes soldiers easier to control by concealing how much of a CrapsackWorld they're in (and how much of that they're responsible for). Withdrawal is ''really'' bad.
* ''VideoGame/HeavyRain'' has triptocaine, a drug that one of the main characters, Norman Jayden, is addicted to. It's up to the player whether he will use it or not.
** Norman is only addicted to triptocaine because he abuses it to suppress the symptoms of another addiction he has: [[CoolShades ARI]], his virtual reality sunglasses that can be very dangerous with overuse and ''really'' screw with your perception of reality. Near the end of the game, keeping them on too long will make his [[TearsOfBlood eyes bleed]], and further use will [[TheManyDeathsOfYou kill him]].
* ''Franchise/MassEffect'' has red sand, a derivative of [[MinovskyPhysics element zero]]. It gives the user temporary [[MindOverMatter biotic powers]], or enhances them if the user is a biotic. Other effects are unknown but it's implied to be extremely addictive and causes nasty psychological side effects, making it a banned substance across nearly all of Citadel space. It's legal on [[WretchedHive Illium]] though, provided one has acquired a license to sell it.
** Hallex, seen in Samara's loyalty mission, causes euphoria and heightened senses. It's probably one of many drugs that originate on alien worlds.
* The city of Billion in ''VideoGame/{{Gungrave}}'' is overrun with crime and a mysterious drug known only as "seed". It's highly addictive and gives the user increased resilience and strength, along with lowered inhibitions and euphoria. However, it eventually drives the user insane and leads to death. Turns out that seed is really [[spoiler: derived from a malevolent race of alien parasites whose [[AlwaysChaoticEvil only reason to live is to reproduce by taking control of other lifeforms]]]]. And it's used in the technology that brought the protagonist back from death and nearly all the enemies he fights throughout the series.
* Dream Leaf in ''VideoGame/GoldenSunDarkDawn'' is an iridescent tree leaf from a semi-sentient (?) tree that acts as a sedative and gives the user good dreams. Its typical use is by old people and insomniacs. In war-torn Border Town, it is taken recreationally by those who want to dream of the good old days [[spoiler: or by our heroes, [[GuideDangIt to access the Haures summon in the blocked-off part of town]]]]. When the Dream Tree is under attack by the ghostly monster Sludge, its leaves instead induce nightmares.
* ''WorldOfWarcraft'' has Bloodthistle, an herb that can only be taken by Blood Elves. When taken, it can increase spell power for ten minutes. On the other hand, it has a twenty minute 'withdrawal', which lowers your spirit. Oh, and it's outlawed in Shattrath City.
** In a lore interview, the blood specialization of Death Knights apparently have blood that works like this, blood that heals their allies (blood tap and bloodworms being the most apparent) are addictive if overused, causing reliance and withdrawls in a way similair to the ghouls of TabletopGame/VampireTheMasquerade.
* The Medic in ''VideoGame/TeamFortress2'' can apparently get high off the fumes from his Kritzkrieg [[HealingShiv medigun]]. It also heals him by +11 health! So, as it turns out, [[FamilyUnfriendlyAesop huffing fumes to get high is sometimes good for you]].
* ''VideoGame/EscapeVelocity Nova's'' [[AllThereInTheManual official timeline]] mentions FATE, a "highly addictive narcotic" created accidentally when scientists tried to use a spaceborne chemical called TCTLIDS to create medicines. [[TheyWastedAPerfectlyGoodPlot The drug does not appear in the game proper, however.]]
** A [[GameMod fan-made sequel]] has 324-florazine iodase (street name "stardust"), which is a regulated but legal antidepressant for humans, and an illegal drug for several alien species.
* The ''[[VideoGame/{{X}} X-Universe]]'' has spaceweed (think [[RecycledInSpace space marijuana]]) and space fuel (a.k.a. Argon whiskey). Both are illegal in the Commonwealth, and both are highly prized by players for pacifying the SpacePirate population.
* UltimaVII features Silver Serpent Venom, which temporarily ups all your stats only to permanently damage them when it wears off. [[spoiler: Hilariously, using far too much of it at once will cause the damage to wrap backwards around the {{Cap}} into an absurd stat ''boost'' when it wears off, making them [[AGodAmI ridiculously strong]] with some very odd effects on game mechanics.]]
* The ''Videogame/{{Gothic}}'' series has swampweed. While it works mostly like marijuana in that it is smoked in joints and affects perception, magic users can benefit from its side effects to enter a trance-like state required for certain magical endeavours. In particular, one of the storyline quests in ''Gothic 2'' requires a priest of each of the three main gods of Myrtana to enter in this trance state with joints of swampweed to help the Eye of Innos regain its power.
* VideoGame/FallenLondon has "prisoner's honey" which transports you physically into a DreamLand. It's regulated, but legal. But stay away from red honey, which is one of the few things that's outright illegal in Fallen London. [[spoiler: Red honey lets you [[MindRape enter somebody else's memories and mess around]].]]
* ''VideoGame/{{Xenoblade}}'' has the red pollen orbs. Out of all the orbs that [[RidiculouslyCuteCritter the Nopon]] manufacture there's the red variety. Like some real drugs, if they are processed correctly they can have some good potential uses, if not, they are very addictive and dangerous for health. There's a group of Nopon that sell this variety illegally to the citizens of [[AdvancedAncientAcropolis Alcamoth]], and [[SidequestSidestory a huge sidequest arc]] involves finding who and where they are and putting a stop to their business.
* According to Yale in Episode 6 of ''[[Creator/ZapDramatic Ambition]]'', Paxwic is a new drug developed to subdue prisoners by making them blissed-out and non-violent. Angie was pursuing a study showing that Paxwic also has the effect of destroying the subject's critical thinking ability, which would make her enemies with the manufacturer Somaplex if her paper on the side effects were to be published. Later we learn that [[spoiler:Ted was injected with an [[ExpoLabel ominously-labeled]] faulty batch of Paxwic which could have ''heightened'' his anxiety just before he woke up to his blood-splattered apartment.]]
* ''VideoGame/FinalFantasyXII'' has a VendorTrash item called Demon Drink which is described as extremely addictive.
* Project Eden has a unnamed (?) drug which increases a users strength and toughness but also transforms them into hideous monsters.
* ''VideoGame/MetalGearAcid'' has ACUA, an experimental combat drug that boosts strength and kills pain. It also plugs the user's mind straight into that of the psychic HiveQueen, theoretically allowing her to coordinate tens of thousands of people as one organism from her Metal Gear. And is quite hallucinogenic (dissociation from reality, disorientation and visual trails are what we see).
* ''VideoGame/BatmanArkhamAsylum'', in addition to Venom (detailed above in Comic Books) introduces Titan, a supposedly improved version that the Joker is working on inside the titular asylum. Its effects are even more dramatic, not just bulking up victims but turning them into misshapen monstrosities (Titan goons with odd-sized arms are common, and [[spoiler:the Joker himself]] ends up with bones protruding from his flesh after taking a dose). In ''VideoGame/BatmanArkhamCity'', [[spoiler:it turns out that Titan causes severe blood poisoning, which actually ends up [[KilledOffForReal killing the Joker for real]].]]
** ''VideoGame/BatmanArkhamOrigins'' introduces TN-1, the precursor to Titan, which causes brain damage (primarily to the memory centers of the mind) as a side-effect. This is used to {{Retcon}} Bane's appearance in ''Asylum'' and ''City''; in ''Origins'' he's similar to his comics counterpart (a GeniusBruiser who's larger than normal men but not ''too'' unrealistic), but after taking TN-1 he turns into a walking mountain of muscle and seems to lose some brainpower in the process.
* ''VideoGame/WeHappyFew'' has Joy, the bliss-inducing drug taken by the citizens of [[FalseUtopia Wellington Wells]] to keep their spirits high and help them forget about [[NoodleIncident the Very Bad Thing]] that happened during the war. [[BigBrotherIsWatching Uncle Jack]] likes to assure the citizens that [[SideEffectsInclude any rumors about Joy causing severe memory loss, paranoia, increased aggressiveness, and other complications]] are [[BlatantLies completely untrue]].
* ''VideoGame/{{Lisa}}'' has a drug also called Joy, it works as a painkiller which on use, ups the persons defenses and attack capabilities in a pinch, at the cost of mutating into a [[HumanoidAbomination hideous monster after consistent use of it.]] [[spoiler: The worst part being that two of the playable characters already start off with Joy-Addictions, [[DownerEnding leaving you knowing what will happen to them.]]]]
* ''VideoGame/StyxMasterOfShadows'' has processed amber, with amber being the liquid sap of the world tree and double as {{Mana}} for Styx to use his various abilities. Though officially prohibited, amber was seen widely traded and smuggled in various parts of Akenash, providing a justified source of bottles of amber lying about or being carried around for Styx to steal.
** It wasn't described what drinking amber does to non-magic using humans, but human amber-users are frequently shown vomiting.
** It was suggested that consumable amber certain hallucinogenic effects on human users. When human enemies briefly sees or hears something moving in the corner (Styx), but then lose perception before they get suspicious, they may say "(Beep-), and I didn't even taken any amber…" and dismiss it as themselves seeing or hearing things.
* Half the plot of ''VideoGame/GrandTheftAutoIII'' revolves around [[TheCartel the Colombian Cartel]] flooding Liberty City with a new drug called SPANK, a perverse cross between cocaine and meth. It seems to be the new 'party drug' for most of Liberty's residents, but extended use can turn it's users into [[spoiler:psychopathic suicide bombers]]. [[EvenEvilHasStandards The Mafia and the Yakuza won't deal with the stuff]], but other gangs, like the Triads and the Yardies, have no such qualms.
* ''VideoGame/FinalFantasyVII'' occasionally dips into this with Mako. In combination with Jenova cells it gives people superhuman abilities and glowing eyes--when exposed to high levels souls become intertwined and a psychedelic VisionQuest results. It's also poisonous, physically addictive, and the Mako therapy use is very bad for one's mental health.
* ''VideoGame/ShinMegamiTenseiIV'' has the Red Pills produced by the [[{{Yakuza}} Ashura-kai]], which are used to quell the demons' [[ToServeMan craving for human flesh]]--seems harmless enough, right? Well, if a human consumes a Red Pill, they transform into a demon. The real kicker is that Red Pills [[spoiler:are made by [[HumanResources harvesting neurotransmitters from the brains of kidnapped and imprisoned humans]] in a secret underground facility.]]
* ''VideoGame/KingdomOfLoathing'' has ''goofballs'', which gives you a nice 20% Muscle and Moxie boost that lasts 10 adventures. It's the withdrawal debuff that gets you thought--you lose 10% of '''all''' your stats until the game considers that you have officially kicked the addiction after going around with the debuff for 30 adventures. Also, the dealer that gives you the first bottle for free [[AdamSmithHatesYourGuts subsequently increase the price of each bottle by 1000 meat with each purchase]].
* In ''VideoGame/StellaGlow'', the protagonist's party runs into mercenaries high on a drug called "nopium" on their journey to [[PortTown Port Noir]] in search of one of the Witches. When ingested, it grants enhanced strength and endurance, but also eats away at the user's mind, driving them insane. They later find out that [[spoiler:[[TownWithADarkSecret the nopium trade is the main reason for the town's prosperity]], and [[CorruptPolitician Port Noir's mayor]] is forcing the Wind Witch to keep the windmill running in order to continue to harvest the stuff. The mayor sends more of the nopium-addled soldiers after them to try to keep them from talking.]]

[[folder:Web Comics]]
* ''Webcomic/SluggyFreelance'' occasionally uses super-scientific drugs in the place of real ones. There was Riff's experiment with [[http://www.sluggy.com/daily.php?date=050107 "Senti-Mental"]] and, of course, ''[[http://sluggy.com/daily.php?date=070605 "Intravenous Drugs From Another Dimension!"]]''
* ''Webcomic/{{Homestuck}}'''s [[OurTrollsAreDifferent trolls]], a race of aliens plagued by violent night terrors, sleep in coccoons filled with a powerful sedative gel called sopor slime, which has effects similar to marijuana when eaten. [[LoveFreak Gamzee]] [[{{Juggalo}} Makara]] is a [[TheStoner chronic user.]] [[spoiler: [[SplitPersonality For]] [[MadArtist a]] [[AxCrazy good]] [[MonsterClown reason!]]]]
* ''Webcomic/TheLydianOption'' has both Janta Leaf (a future "soft drug") and highly addictive blue alien fruit.
* In ''Webcomic/{{Sinfest}}'', [[http://sinfest.net/view.php?date=2012-04-10 Jogs, apparently.]] [[http://en.wikipedia.org/wiki/Endorphin#Runner.27s_high Some truth in the matter…]]
* Several of ''Webcomic/FairyDust'' 's creatures have mind altering toxins.
** Fairies' dust is a hallucinogen, elves' venom is a hypnotic and anesthesic, and incubae's is a dissociative.
** Unicorns' proximity causes euphoria and mental regression, but no chemical causing this effect has been identified so far.
* [[spoiler: Bo's zombie blood]] in ''Webcomic/MonsterSoup''.
* ''Webcomic/{{Erfworld}}'' shows that Hippiemancers can create these. They look like little pink flowers, but are insanely addictive and eventually fatal. The BigBad of Book 0 uses these to control her entire side. She names them hero buds, or ''heroine'' if the user is female.
* Captain Tagon from ''Webcomic/SchlockMercenary'' mentions in a reminiscence about what happened to a unit given far too much room for their quarters something called "hyperjuana", which from the name is probably some kind of extra powerful marijuana equivalent.
* ''Webcomic/NeonIceCreamHeadache'' is named after Neon Ice Cream, a drug that causes its user to be TrappedInTVLand.
* ''Webcomic/{{Runners}}'' 'verse has crush, which for some reason [[StuffBlowingUp tends to explode violently]] in addition to turning entire villages of Ulon Dosi into {{Opium Den}}s.

[[folder:Web Original]]
* ''TheTaleOfTheExile'': The elves of The Physician's Guild use an extract from the [[PunnyName Elisdee Lily]] as an antiseptic. Unfortunately for the main character, a side effect of Elisdee exract is [[MushroomSamba wild hallucinations]]. It's implied that the elves actually [[MorallyAmbiguousDoctorate sell the extract to patients once they become addicted to the hallucinations]].
* In the {{GURPS}} adventure based on the Literature/ChaosTimeline, one dealer tries to sell the [=PCs=] the drug "black niig", which supposedly makes people feel "like Stalin [[note]]Not our UsefulNotes/JosefStalin, but still a bad guy[[/note]], when he [[GroinAttack crushed his enemies' balls]]", and later they meet a crazy fundamentalist Christian who claims he knew a girl who never listened to advice, took nanodrugs and one day literally fell apart to dust.
* The unnamed "cloudy drink" that is supplied to all the inhabitants of the eponymous ''WebVideo/SexHouse'' when they refuse to have sex.
-->'''Tara:''' [[spoiler:[[MadnessMantra Cloudy drink kills frog!]]]]
* Prifleden in ''Literature/AvalonsReign'' is a completely legal drug injected through a needle (a "hypo") that fires off the pleasure center of the user's brain. Some people call it "orgasm in a needle", but others claim the high is much more intense than that. The company that produces it advertises the drug as non-addictive, but this does not appear to be true.

[[folder:Western Animation]]
* Spin, from the ''WesternAnimation/{{Bravestarr}}'' episode "The Price". It has a level of addictiveness bordering on CompressedVice. Its effects are shown to be violent, with many users being taken to the hospital, and the kid who is the focus of the episode [[spoiler:dying at the end]].
* ''WesternAnimation/CaptainPlanetAndThePlaneteers'' did this trope with an anti-drug episode, "Mind Pollution", where the drug in question (oh-so-creatively called "Bliss") turns its victims into strung-out hollow-eyed zombies. Like "Bravestarr" sample above, [[spoiler:Linka's cousin, Boris dies.]] The episode even calls it a "new designer drug."
* The ''GIJoe'' VerySpecialEpisode "The Greatest Evil" featured a drug known as "Sparkle" which was sparkly red in color. The episode did go some way further than most of its type, however, in displaying relatively realistic effects of its use; one character was hospitalized with an overdose. At the end of the episode, the villainous drug-dealing Headman is unambiguously killed when he accidentally overdoses on his own drug, a rare moment for an episode of the type.
** Of course, the message of said episode is a little lost when you consider that the main plot suggests that drug dealers were a greater threat than heavily armed international terrorists, for whom EvenEvilHasStandards, leading to the EnemyMine situation of them teaming up with the good guys.
* In ''WesternAnimation/TheSpectacularSpiderMan'', the series pays homage to the storyline about Harry Osborne's drug addiction in the comics by using the PsychoSerum "Globulin Green".
** Which has the fortunate side-effect of merging two of Harry's biggest storylines, his drug addiction and his eventual becoming of the Green Goblin (which is alluded to in the series, as [[spoiler: he is originally thought to be the Green Goblin before its revealed Norman's been manipulating Harry into taking the fall for him. Besides making the Harry story tighter it also makes the reveal of Norman Osborn being the Green Goblin a genuine shock for the first time in over forty years!]])
* In ''WesternAnimation/BuzzLightyearOfStarCommand'', Mira becomes addicted to phasing through radiation, because as we all know, [[ILoveNuclearPower radiation gives you superpowers]]! However, it also apparently gives you withdrawal, unkempt hair, and a really creepy voice.
** {{Justified|Trope}} by BizarreAlienBiology.
* ''WesternAnimation/BatmanBeyond'' did a story about steroid use in athletics without using the word "steroids". They were "slappers" and turned out to contain the Venom used by Bane. The effects of Venom, of course, are ''much'' more disturbing than those of steroids.
** ''Batman Beyond'' loved this trope. Splicers used animal mutagens to make a drug-like culture (no adverse or overt addictive side-effects were shown, but the Splicers were portrayed as being deviant and intrinsically more confrontational) and total-immersion Virtual Reality (basically computer-generated euphoric hallucinations) was portrayed as being very addictive, with catastrophic side effects inevitably resulting from prolonged use. Both episodes were very dark and laced with terrifying imagery, particularly the Splicer episode, which culminated with Batman defeating the bad guy by splicing him over and over again with different animals until the [[OneWingedAngel villain]] had a SuperpowerMeltdown.
* Stimutacs, from the ''WesternAnimation/{{Sealab 2021}}'' episode of the same name, are a fictional drug derived from the venom of the fugu invented by Sparks to make an assload of cash. HilarityEnsues.
-->'''Marco:''' I have the strength of a bear that has the strength of '''two''' bears!
* An episode of Creator/{{ABC}}'s version of ''WesternAnimation/{{Doug}}'' had a tobacco analogue called Nic-Nacs, which could cause people's mouths to freeze up.
* In an episode of ''WesternAnimation/HarveyBirdmanAttorneyAtLaw'', Birdman became addicted to a tanning cream that gives him massive boosts of energy because he's solar powered. It showed him selling all of his stuff to get more and end up getting a sort of intervention.
* Bender from ''WesternAnimation/{{Futurama}}'' loves to smoke and drink, but that's okay since he's a robot. However, robots can become addicted to electricity, as Bender did in "Hell is Other Robots". It eventually caused him to be dragged to Robot Hell…
** Similarly in "The Butterjunk Effect" Leela and Amy become addicted to a performance enchancer marketed as "Nectar", which comes from a species on Kif's planet. Near the end of the episode they have to kick the stuff and go through severe withdrawal doing so.
* ''WesternAnimation/{{Metalocalypse}}'' had "Totally Awesome Sweet Alabama Liquid Snake", a drug that would get you "so high your brain will blow chunks into the Milky Way." [[ImmuneToDrugs It has no effect on Pickles.]]
--> '''Pickles:''' I grew up smokin' government weed everyday, you know…
* ''WesternAnimation/TheSmurfs'' episode "The Lure Of The Orb" hides a story of the effects of drug addiction behind the use of a magic orb that's supposed to give enlightened inspiration to whoever uses it.
* The ''Franchise/MyLittlePony'' special "Escape from Katrina" features a CatGirl witch named Katrina who was addicted to a powerful PsychoSerum called "Witchweed Potion". She tries to capture the ponies as ''slave labor'' for gathering the ingredients so she could make more. Interestingly, while Katrina ''does'' eventually kick the habit and make a HeelFaceTurn, this only happens at the last moment before she would have otherwise ''died'', namely by falling into a pit of her own potion. [[GoodIsNotSoft And it's only because of her promise to kick the habit that the heroes save her life.]]
* On ''WesternAnimation/OvideAndTheGang'' a.k.a. ''Ovide Video'', there was a certain flower that, when sniffed, would make anybody extremely happy and relaxed. As in, ''very'' mellow, laid-back, and agreeable. The villain of the show hated the flowers, as he didn't like getting along with others, but many episodes ended with him being ''forced'' to take a sniff. So in a nutshell, all the good guys on the show would sniff a flower to get high, and the villain didn't want to but was usually coerced into doing it. ''On a kid's show.''
* It is implied in ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' (specifically, "Over A Barrel") that salt acts like alcohol for ponies.
-->''A pony gets thrown out of a saloon called "The Salt Lick"''
-->'''Saloonkeeper:''' That's enough salt for you!
-->'''Salted pony:''' Can't I at least get a glass of water?
* In ''WesternAnimation/CloneHigh'', Creator/JackBlack expy Johnny Hardcore comes to the school to warn the students about the dangers of "doing raisins." [[DoNotDoThisCoolThing Reverse psychology drives them all to try it, of course.]] [[spoiler: Which is exactly what the council of raisins wanted in order to sell more, although this example of FantasticDrug is an aversion because the entire buzz they give is nothing more than a placebo effect.]]
-->'''Abe:''' Hm. I don't really feel anything… Well, I have a strong constitution, so I don't really ''I CAN TASTE THE SUN!!!''
* ''WesternAnimation/TransformersPrime'': The synthetic Energon has this effect on Ratchet, making him increasingly unstable. This is a rare example of the drug being made by the affected party.
--> '''Bulkhead:''' Stronger, faster, studlier.
* ''WesternAnimation/TheSimpsons''
** Tomacco, a tomato/tobacco hybrid accidentally invented by Homer. It's very addictive and makes people aggressive. Eventually a tobacco company executive tries to steal the last plant, which leads to [[AssholeVictim his helicopter being brought down by a tomacco-addicted sheep.]] (The sheep survives.)
** Swank, a drug marketed by the [[ShowWithinAShow villain in a movie Bart and Homer watch]]; it is ten times more addictive than marijuana.
* ''WesternAnimation/TronUprising'': In "Price of Power," the experimental weapon makes Beck faster and stronger, but also far more aggressive. The fact that this was allowed on a Creator/DisneyXD show was probably because the situation was applied to computer programs as opposed to humans.
* ''WesternAnimation/SouthPark'': The episode "Major Boobage" has the town in a moral panic over "cheesing"--getting high off cat pee (where their hallucinations are a parody of ''Film/HeavyMetal'').
** From the latest episode, the titular Member Berries, which placate people by talking about nostalgic things, like "Member Chewbacca?" or "Member Ghostbusters?" But there is a side effect; after a while, they start saying things like "Member when there weren't so many Mexicans?" and "Member when marriage was just between a man and a woman?"
* The ''WesternAnimation/DoubleDragon'' animated series gives us RPM, a drug that turns its users into hulking blue monsters with super strength. The Shadow Master was able to make it out of a natural alien substance called Black Fungus.
* In ''Westernanimation/{{Phantom 2040}}'', simulations of the natural environment from before the Resource Wars are portrayed like addictive drugs, complete with strung-out junkies going without food for a hit, and getting violent when their session is interrupted.

[[folder:Real Life]]
* There have been a number of cases where jokes from comedy and Internet hoaxes have been taken seriously: [[Series/BrassEye cake]], bananadine, and jenkem (supposedly a fadding drug among teens, created by storing raw sewage in a plastic bag for a week or so) have each raised their share of moral panic before people realized they were fake.
** The latest of these would be strawberry Quik-flavored meth.
*** This one is at least based in reality. If allowed to dissolve in the mouth, some specific formulas of generic Adderall and/or Ritalin have a flavor very similar to strawberries.
** ''VideoGame/TheSecretOfMonkeyIsland'''s grog recipe was picked up by [[https://www.youtube.com/watch?v=XdgJfHDS4YE an Argentinian news show]] and promoted as a real thing teenagers drink. As an added bonus, they interpreted the original poster's emoticon as part of the name: "Grog XD".
* On surveys about school environments, students will sometimes be asked how many times in the past thirty days they've taken Panda B; there is no such drug, and if someone says they've taken it, their survey answers can be disregarded because they're obviously lying.
* Then there is the UrbanLegend of [[http://www.snopes.com/horrors/drugs/bluestar.asp "Blue Star Acid."]] There's no evidence that "lick-n-stick tattoos" have ever been used to distribute LSD, or any other substance, to kids.