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->''"That's why I never kiss 'em on the mouth."''
-->-- '''Jayne Cobb''', ''Series/{{Firefly}}''

A character (naturally, usually a woman) wears lipstick with some sort of drug or poison in it, with the result that anyone who kisses her is affected by it. Only very rarely is it explained [[FridgeLogic why the wearer of the lipstick is immune]]. (In all likelihood, she has access to an antidote she takes beforehand.)

Compare KissOfDeath, PostKissCatatonia.

[[folder:Anime and Manga]]
* In ''Anime/SamuraiChamploo'', a woman called Hotaru is revealed to be an assassin who uses a special kind of lipstick that becomes toxic when mixed with alcohol. Luckily Mugen figured this out pretty quickly.
* There's a variation in ''Manga/BloodyCross'' where Hinata uses his ''tongue'' to apply a spell to knock Tsukimiya out under the guise of [[LecherousLicking examining]] the [[BuxomIsBetter location]] of her curse mark.
[[folder:Comic Books]]
* This was a favorite tactic of Poison Ivy in her early appearances in the Franchise/{{Batman}} comics. Gradually she gained the ability to [[PoisonousPerson generate poisons in her body]], negating the need for the drugged lipstick.
* It's later revealed in the ''ComicBook/TheBatmanAdventures'' comics that [[spoiler:the green-skinned, super-powered version of Poison Ivy was actually a body double created by the real one who had forgotten she was a clone. She thought her body becoming more plantlike was a result of it absorbing the poisons she worked with and giving her superhuman powers but it was actually due to it [[CloneDegeneration breaking down because she was never meant to live longer than it took for the real Poison Ivy to make a clean getaway from Gotham City]].]]
* ''ComicBook/ABCWarriors'': Morrigun also uses this to kill at least one human. Being a robot helps a lot when dealing with poisons that turn [[BodyHorror humans into plants]].
* ''ComicBook/TheDarkKnightReturns'' shows us why it is a ''[[KillEmAll very]] [[MasterPoisoner bad]] [[OmnicidalManiac idea]]'' to let ComicBook/TheJoker bring along his own lipstick to a [[ItMakesSenseInContext talk show taping]].
-->'''Make-Up Guy:''' You want lipstick, sweet guy?
-->'''Joker:''' No need. I brought my own.
-->'''[[TooDumbToLive Dr. Wolper]]:''' [[WhatAnIdiot Nice to see you taking an interest]]...
* ''Magazine/DoctorWhoMagazine'': In "The Broken Man", Amy Pond escapes from an MI6 agent by kissing him with a drugged lipstick (implied to be gift from River Song).
* One Franchise/{{Superman}} villainess infected the Man of Steel with a form of Kryptonite-like cancer by kissing him with drugged lipstick.
* In ''ComicBook/TheSpirit'', the Black Widow used poisoned lipstick. She put it on top of a layer of ordinary lipstick to avoid its effects.
* In ''ComicBook/ThePunisher'', a vigilante called Raving Beauty used poisoned lipstick to kill the men who had wronged her and forced her into drugs and prostitution.
* In a ''Anime/HeatGuyJ'' {{Yaoi}} fanfic called [[http://www.fanfiction.net/s/2718711/1/In_A_Different_Light "In A Different Light,"]] there is a mention of a fantasy club-drug called Black Tab being mixed into lipstick and eyeliner, so that the wearer can absorb them into his/her skin and get high without, say, getting caught with a bag of pills.
* Appears in ''Fanfic/WithThisRing'', where the main character finds it ridiculous.
* The LesYay UsefulNotes/HongKong action movie ''Naked Killer'' (1992): Poisoned lipstick is used on a couple of occasions.
* In the spy flick ''The Ambushers'', a beautiful enemy agent offers hero MattHelm a drink of whiskey. After he declines, she takes a drink herself, puts on lipstick, and starts kissing him. The lipstick is poisoned, and the whiskey is the antidote!
* Poison Ivy in ''Film/BatmanAndRobin'' actually has poisonous ''lips'', and kills the mad doctor inadvertently responsible for her creation with a kiss. [[spoiler:She tries to do the same to Robin later, but the rubber lips he's wearing protect him.]]
* ''Film/{{Holes}}'' has a variant; the Warden's nail polish has rattlesnake venom in it, which she assures someone she scratches is perfectly harmless - when dry. In a case of either BlatantLies or ArtisticLicenseBiology once the nail polish dries, all of the venom that would be left are the deadly toxins.
* In ''Film/LaReineMargot'' the resident MasterPoisoner gives Henri of Navarre's lover some poisoned lipstick. An unusual example in that this ''does'' in fact kill the woman wearing it; she was an UnwittingPawn and was deemed expendable as long as she inadvertently killed her target. [[spoiler: She failed, the poison was too fast-acting and it killed her before she got a chance to use it on him.]]
* ''Literature/FloraSegunda'' mixes sleeping powder into her lip rouge to take down Springheeled Jack.
[[folder:Live Action TV]]
* In ''Series/{{Smallville}}'', Lois once had [[spoiler:red kryptonite]] lipstick. Subverts the immune part, which would oddly be justified if played straight because [[spoiler:red kryptonite is not supposed to affect humans.]]
* River Song uses hallucinogenic lipstick in the ''Series/DoctorWho'' episode [[Recap/DoctorWhoS31E4TheTimeOfAngels "The Time of Angels"]], and [[ContinuityNod again]] in [[Recap/DoctorWhoS31E12ThePandoricaOpens "The Pandorica Opens"]] -- twice. Finally, she uses it a fourth time on [[spoiler:the Doctor himself]] in [[Recap/DoctorWhoS32E8LetsKillHitler "Let's Kill Hitler"]]. Except this time [[spoiler:it's poisoned]].
* RareMaleExample in the ''Series/{{Torchwood}}'' episode "Kiss Kiss, Bang Bang", Jack tells Gwen not to let Captain John Hart kiss her; when he does, it turns out that it's because he wears paralyzing lipstick. Oddly enough, Jack himself seems to be immune, as Jack and John repeatedly engage in SlapSlapKiss and KissKissSlap throughout the episode. (Though John did disappear right before he kissed Gwen, so he could have been putting it on then and could have taken it off afterward when he kissed Jack goodbye.)
* In the ''Series/{{Firefly}}'' episode "Our Mrs. Reynolds", Saffron wears lipstick with some kind of soporific property, which she uses to knock out Mal (and, indirectly, Inara). Simon, the ship's doctor, explains that he frequently dealt with unconscious men being brought in on the night shift who had been drugged and robbed.
-->'''Simon:''' A narcotic compound, probably spread over a seal on her lips. You get it on yours and pow. We used to get a lotta guys brought in on the night shift at the E.R.--usually robbed, very groggy. They called it the "goodnight kiss".
* This happens in an episode of ''Series/LoisAndClark'' with kryptonite lipstick.
* In the ''Series/GilligansIsland'' episode "The Invasion", Gilligan dreams that he's secret agent 014. During the dream, Ginger Grant's character wears poisoned lipstick, but 014 is prepared with lip guards.
* At least a couple of times during the run of ''Series/GetSmart'': once a bad girl wears some and tries to kiss Max -- luckily he has his [[ShoePhone lip protector]] on; and once 99 wears some and uses it to knock out (not kill) a bad guy who's about to kill her and Max (her LastRequest is a LastKiss...from the bad guy!). Surprisingly for the show, the KAOS girl is always shown to first apply a "protective undercoating" to her lips. Even ''more'' surprisingly for the show, she never mixes the two up.
* Angel of Death from the TV series ''Series/BlackScorpion'' uses poison lipstick as a weapon.
* In ''Series/ArrestedDevelopment'', GOB puts ether on the lips of his ventriloquist dummy, Franklin, and knocks people out by having Franklin kiss them.
* In an episode of ''Series/{{No Ordinary Family}}'', Jim loses his superpowers. It turns out that cynoxate, an ingredient in Stephanie's lip gloss, is the kryptonite to Jim's AppliedPhlebotinum, the trilsettum coronis. She claims to have gotten rid of it, but apparently still has it lying around, because in a later episode, the evil shape-shifter Victoria turns into Stephanie and steals the lip gloss, neutralizing Jim's powers when she kisses him.
* The ''Series/{{Charmed}}'' episode "Bride and Gloom" has a demon who steals the lipstick Prue was just wearing so he can cast a spell on it, making it so that when he kisses her with it she gets paralyzed and he can force her to marry him.
* ''Series/{{Nikita}}''. Nikita's lipstick contains peanut oil, which Victor Han is deathly allergic to. She manipulates him into kissing her, and he goes into anaphylactic shock
* In ''Series/SixHundredSixtySixParkAvenue'', Olivia Doran puts on poisoned lip gloss and kisses her husband's enemy, Frank Alpern, who immediately collapses.
* Subverted in an episode of ''Series/{{CSI}}'' where some prostitutes put sedative on their nipples so they can knock out clients and rob them. Unfortunately, it knocks them out too.
* In ''Series/AgentCarter'', Peggy uses her 102 SWEET DREAMS lipstick tube to knock out a black market dealer/nightclub owner. [[LesYay A female assassin later steals it to use on Peggy.]]
* ''Series/GameOfThrones''. Princess Myrcella is given a goodbye kiss by Ellaria Sand. [[spoiler:Unfortunately her lips are coated with a delayed-action poison which kills her a short time later. Ellaria just takes the antidote after the princess has left.]]
** In Season 7, [[spoiler:Cersei returns the favor to Ellaria by kissing her daughter, Tyene, which the same poison used to kill Myrcella and forcing her to watch her daughter die and rot in chains]].
[[folder:Tabletop Games]]
* The bloody cochineal poison in the ''TabletopGame/LamentationsOfTheFlamePrincess'' module ''No Salvation for Witches''. It at least addresses the immunity issue by specifying that the poison has no effect on women, somehow. (Presumably [[AWizardDidIt it's magic]].)
[[folder:Video Games]]
* In ''VideoGame/FallenLondon'', you can buy a kiss from Sinning Jenny during the Feast of the Exceptional Rose. Normally the kiss goes off without a hitch, but there's a rare possibility of Sinning Jenny turning out to be wearing poisoned lipstick that knocks you out because someone unknown paid her to harm you.
[[folder:Western Animation]]
* ''WesternAnimation/BatmanTheAnimatedSeries'':
** In her earliest appearances, Poison Ivy is shown applying drugged lipstick to create her toxic kisses, something she uses against Harvey Dent and Batman in her first episode. Later episodes make the poisonous kisses natural, and show her creating doctored lipstick for Harley Quinn to use in order to cause the same effect. Whether this is a [[RetCon retcon]] or an implication that Ivy's powers evolved over time (a reasonable hypothesis, given other changes, like her skin color) is unknown, but as she does possess an antidote to her own poisons and was later shown giving Harley Quinn an injection for the same, it can be assumed that even in her earliest appearances she'd already treated herself to prevent from being poisoned.
** There's the episode ''Holiday Knights'' which was split in three parts. The first part dealt with Bruce Wayne being kissed by Harley Quinn, who, along with Poison Ivy, kidnapped him and made him spend a ridiculous amount of money on them. When the lipstick began wearing off, Harley tried to kiss him again.