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[[quoteright:350:[[VideoGame/DestroyAllHumans http://static.tvtropes.org/pmwiki/pub/images/disintegrator-ray_destroy-all-humans_4523.jpg]]]]

->''Being a device that flouts conventional scientific consensus that the molecules composing the human body must be arranged "just so", and not, for example, across a square-mile radius.''
-->-- '''[[FrickinLaserBeams Manmelter]] description''', ''VideoGame/TeamFortress2''

The cleanest variety of DeathRay. Whatever it strikes, be it commoner or king, is reduced to little more than sand and ozone (or simply vanishes in a flash of light). A great way to save money on special effects and not have to [[NoBodyLeftBehind litter the place with corpses]] or blood. Only a few stories will bother to [[HandWave elaborate]] on where all that matter actually goes, or how the ray gun "knows" to stop disintegrating things once the original target is vaporized (rather than [[GreyGoo disintegrating everything in the area]] up to and including the [[EarthShatteringKaboom very planet]] everyone is standing on).

Be warned, however. If you should [[DeaderThanDead fall foul of a Disintegrator Ray]], it may take much more than a stay at the TraumaInn to cure ''that'' [[StandardStatusEffects Status Effect]]. Even people whose HealingFactor can reconstitute their bodies FromASingleCell would have trouble doing so from a single ''atom''. If the shot is somehow shrugged off as not instantly lethal but still hurtful, expect it to hit ForMassiveDamage.

This may also make it the weapon most vulnerable to the InverseLawOfUtilityAndLethality.

A SubTrope of RayGun.


[[folder:{{Anime}} and {{Manga}}]]
* In ''Manga/{{Naruto}}'', Dust Release works like this.

* The second major invention of Baron Zemo (CaptainAmerica's once-archenemy from WWII), eventually revealed as being--tada!!--a laser beam.
* It requires physical contact, and so isn't technically a ray or laser beam or whatever, but the "vibrate through molecules" ability each [[TheFlash Flash-type speedster]] possesses can be used offensively as a disintegrator.
* {{Darkseid}}'s most oft-seen use of his [[EyeBeams Omega Beams]] is to disintegrate anyone he chooses. Furthermore, if he changes his mind, Darkseid can restore anyone so hit just as easily.
* {{Foolkiller}}'s "Purification Gun" works this way; [[SuspensionOfDisbelief no attempt has ever been made to explain where it came from or how it works]], which was intentional on the part of creator Steve Gerber.

* ''Literature/TheWarOfTheWorlds'':
** In the [[Film/TheWarOfTheWorlds1953 1953 Hollywood movie adaptation]], the "heat ray" truly could burn tanks to ashes, but for extra appeal, the war machines gained a second weapon, the green "skeleton beam" which "neutralized mesons," truly causing its victims to vanish in a glow of green light.
** The [[Film/TheWarOfTheWorlds 2005 Spielberg adaptation]] included not only a scene with many fleeing civilians getting disintegrated, but also a scene afterwards where the protagonist realizes that he's covered in ''people'' dust.
* The plot of ''ThePinkPanther Strikes Again'' has the crazed Chief Inspector Dreyfus threatening the world with a ray that leaves next to nothing behind unless Inspector Clouseau is killed. [[spoiler:The villain is HoistByHisOwnPetard at the end. Perhaps due to {{sequelitis}}, he got better.]]
* ''Film/QueenOfOuterSpace'' (1958). Yllana, the dictatorial matriarch of Venus, has the Beta Disintegrator which can destroy Earth in minutes. Though given her [[LadyLand rampant hatred of men]], she should have dubbed it the [[IncrediblyLamePun Alpha-Male Disintegrator]] instead.
* ''Film/SkyCaptainAndTheWorldOfTomorrow'' homages all of MadScience, including a hand held disintegrator pistol that fires a little blue ring that disintegrates a neat hole through a foot of metal.
* ''Film/MarsAttacks'' has the Martians armed with disintegrators that leave a brightly colored skeleton behind.
* The dirtship in ''Film/TheCore'' has an ultrasonic beam at the front that disintegrates everything in front of it so it can travel through to the center of the Earth.
* Gort's eye beam in the original ''Film/TheDayTheEarthStoodStill1951''. Used to disintegrate tanks, artillery pieces and individual weapons.
* ''Film/EarthVsTheFlyingSaucers''. The beams emitted from the hands of the invader's armor suits and (sometimes) the devices in the bottom of the invaders' ships.
* ''Film/TheAmericanAstronaut'': [[MadScientist Professor Hess]] has a handgun that can turn people to ash if they forget his birthday.
* The electro-fragmentizer room in ''OurManFlint''.
* Though [[InformedAbility it never occurs in the trilogy]], Darth Vader feels it prudent enough in ''TheEmpireStrikesBack'' to warn Boba Fett "[[IWantThemAlive No disintegrations]]" when sending the bounty hunters after the ''Millennium Falcon''.
** In one of the video game adaptations, there is a disintegrator grenade InNameOnly.
** In VideoGame/EmpireAtWar the expansion includes units wielding disintegrator rifles.
** Some EU tech books describe these, aparently they work like blasters do except turned UpToEleven, causing the heat to melt the whole person rather than sear holes through people.
* ''WesternAnimation/HeavyMetal''. In the "Harry Canyon" segment, the title cabbie is betrayed by a woman he helped: he destroys her with a device installed in his cab to prevent robberies.
* ''Film/{{District 9}}'': One of the weapon causes people to 'pop' leaving only a few splashes of blood.
* ''Film/FlashGordon'' (1980). The flying robot in Ming's palace uses one to destroy an escaping lizard man and the pistol in Dr. Zarkov's pocket.
* The [[CosmicKeystone Tesseract]]-powered EnergyWeapons used by HYDRA in ''Film/CaptainAmericaTheFirstAvenger'' fire blue bolts that violently explode when hitting an inanimate object and disintegrate any person hit with it. They only object immune to it (but not the knockback effect of the heavier versions) is Cap's own Stark-designed [[{{Unobtanium}} vibranium]] shield. The weapons are later [[spoiler:collected and stored by [[Film/TheAvengers SHIELD]] in order to build weapons with which to defend Earth]].

* The Martian "Heat Ray" in H. G. Wells' 1898 novella ''Literature/TheWarOfTheWorlds'' is one of the earliest examples of this trope, although it did tend to leave messy burnt bits around the edges of the blast zone.
** Inside the blast zone, the messy burnt bits are smaller and harder to notice.
** The "Heat Ray" was a death ray. The first true disintegrator appears in the 1898 ''Edison's Conquest of Mars''.
* The quark-level dissociator spell from the ''YoungWizards'' series.
* In ''Literature/{{Ringworld}}'' and Creator/LarryNiven's other ''Literature/KnownSpace'' stories, the [[AbusivePrecursors Thrintun Slavers]] left a lot of their LostTechnology lying around in stasis, including a disintegrator digging tool that suppresses atomic valence-- atoms simply fly apart. It is weaponized to slice a miles-deep canyon into a planet during the Man-Kzin wars.
** The planet is now known as "Canyon", for it's defining feature.
** ...And the weapon was called the "Wunderland Treatymaker" for ''it's'' defining feature.
*** The details are amusing enough to relate: one version of the Slaver Disintegrator suppressed the charge on electrons. Another suppressed the charge on ''protons''. Neither version acted quickly enough to be useful as a weapon, but if two beams were fired in parallel, current would flow between them. ''Lots'' of current.
* The "Little Doctor" (from "Doctor Device", from "M.D. device", from molecular disruption device) in ''Literature/EndersGame'' is an especially potent version. While later books in its original form it fires a pair of beams which generate a field that breaks atomic bonds at the point where they meet -- and uses the energy released to expand the field, with the end result that a single shot could take out a target of any size, anything nearby, and so on in a chain reaction limited only by the vast void of space. Needless to say, the weapon was only used in space combat. [[spoiler:At least until Ender had it used on the buggers' homeworld.]]
** In later books, the weapon is [[RetCon retconned]] as a missile.
** The prequel novel ''Earth Unaware'' has the "gravity laser" (or "glaser"), originally meant for very efficient [[AsteroidMiners asteroid mining]] but proving extremely effective against Bugger/Formic ships. It works by firing a focused gravity beam that breaks apart targets into atoms. It's heavily implied that the glaser is the ancestor of the Little Doctor.
* In the ''Literature/{{Animorphs}}'' series, the Yeerks' Dracon beams were deliberately engineered to disintegrate living targets [[KickTheDog slowly and painfully]]. Other weapons did so more cleanly.
* The disruption-balls fired by "The Gun That Shot Too Straight", in Ralph Roberts' short story.
* Another of these weapons that works ''too'' well appears in Creator/RobertSheckley's short story "The Gun Without a Bang."
* The balefire weave of ''Literature/TheWheelOfTime''. Manifests as a beam of light that instantly banishes whatever it touches from existence, not even leaving dust behind. The destruction visited upon the target is so extreme, being killed with balefire [[DeaderThanDead prevents a person from]] [[BackFromTheDead being brought back to life]], even by [[PhysicalGod gods]]. If that isn't enough, contact with balefire also ''burns the very actions that the person recently took [[RetGone out of existence, undoing them]]''.
* A disintegrator ray is the weapon ultimately (and accidentally) created in the Creator/ArthurCClarke short story "Armaments Race" in ''Literature/TalesFromTheWhiteHart''.
* ''[[http://www.gutenberg.org/etext/19174 The Man Who Rocked the Earth]]'' by Arthur Train and Robert Wood.
* Disintegrators are one of the earliest stock energy weapons introduced in ''Literature/PerryRhodan''. They work on the "disrupt molecular bonds" principle and so turn whatever they touch into expanding gasses and/or very fine dust; since the beam only affects what it touches ''directly'' (and doesn't, say, expand from that spot to magically consume the whole person or object), the technology has practical applications away from the battlefield as well.
* The Ultravibe weapons in Creator/RichardKMorgan's ''Literature/BrokenAngels'' effectively did this... they were presumably some sort of intense directed broad-spectrum ultrasound device which vibrated targets apart. Used as battlefield weapons and mining devices. One character is hit by a big, warship-mounted version of these and is reduced to a thin, smooth red paste coating the surfaces of the docking bay he was in.
* Creator/IsaacAsimov's robot story "Robot Al-76 Goes Astray". A robot creates a Disinto device powerful enough to destroy the top 3/4 of a mountain.
* Colin O'Boyle's serialized novel, TheChroniclesOfProfessorJackBaling, has one of these. After the main character accidentally shoots his kitchen island, it shivers, takes on an ashy appearance--as though a newspaper image of the island had been lit on fire--and then collapses into a pile of dust.
* In ''{{Literature/Doom}}: Endgame'', Fly is introduced to the Fred ray. The disintegrator weapon disturbs him because it has no visible emissions and just erases things from reality.

* Used to the point of annoyance on ''Franchise/StarTrek'' for years. No one seemed to ever use the settings on phasers that were between ''stun'' and ''unmake utterly without burning the carpet''...intentionally, at least. In the TOS episode ''[[http://en.wikipedia.org/wiki/The_Conscience_of_the_King_(TOS_episode) The Conscience of the King]]'' Lenore accidentally kills Karidian without disintegrating him, but a master of phaser use and safety, Lenore was not.
** Also, Karidian needed to give a FinalSpeech. This was the sole exception to the rule in TOS (if we don't count super-strong aliens who could shrug off phaser fire altogether.)
** A couple of [[Series/StarTrekTheOriginalSeries original-series]] episodes used a hand-phaser heat-ray setting to warm up a rock on a cold world, and coffee during a power outage, respectively, serving Roddenberry's vision of phasers as ''tools that are incidentally weapons.''
** There was one ''[[Series/StarTrekDeepSpaceNine Deep Space Nine]]'' episode where a DisintegratorRay used by [[ThoseTwoBadGuys a couple of snarky murderers]] ''did'' burn the carpet after unmaking their unfortunate target. "Oh? Now look what you did to the rug." They covered the stains with a chair, which was not enough to fool Odo.
** In ''[[Film/StarTrekVITheUndiscoveredCountry The Undiscovered Country]]'' Star Fleet subversives were [[RewardedAsATraitorDeserves disposed of]] via a point-blank [[StunGuns phaser on stun]]. Rumor has it there's an episode in The Original Series where this phenomenon was mentioned. Then the topic was tabled until ''[[Series/StarTrekTheNextGeneration Next Generation]]'' era and beyond, during which phasers had ten settings and up.
*** But it was established in ''TNG'' that the phaser's highest setting didn't actually burn or vaporize, it broke down matter into Technobabblium particles which harmlessly dissipated. It's a plot point in one of the season-end three parters, when the crew scan the floor near a phaser shot for said particles to find if Picard was really killed, or just beamed away.
*** In one episode both Riker and Picard fire phasers at a human possessed by alien bugs, causing [[YourHeadASplode his head to explode]] and left behind a bloody corpse. Evidently this effect and the whole episode/storyline didn't go down too well.
** In the original series episode "The Apple", a ''lightning bolt'' acted as a DisintegratorRay.
** And in the original series episode "The Changeling", Nomad's beam weapon vaporized many a red-shirt without trace.
** In ''Film/StarTrekTheMotionPicture,'' V'Ger disintegrated ''entire Klingon battle cruisers.''
** In the ''TNG'' episode ''The Most Toys'' there is the Varon-T Disruptor, which combines this ''and'' AgonyBeam, as it tears the body apart at the molecular level from the inside out, resulting in a relatively slow and excruciating death by disintegration compared to most phasers and disruptors, which is why it was banned in the Federation and only five were ever made.
* Three shots of a Zat gun on ''Series/StargateSG1'' ''used'' to do this, but after the writers realized it was stupid, they quietly stopped using that function.
** A joke in a later episode implies that a ''fourth'' shot will reintegrate the target.
** Parodied in the "[[ShowWithinAShow Wormhole X-treme!"]] episode, where a producer considers the concept "the dumbest thing I ever heard!"
** The Zat gun went through a few changes over the course of the show. Originally, a single shot from the gun would wrack people with tortuous agony, but at some point along the way, this was replaced with a simple, humane "stun" effect.
** The Asgard used their [[TeleportersAndTransporters transporter systems]] this way to spectacular effect in a second season episode, with a single ship [[CrowningMomentOfAwesome completely disintegrating three pyramid ships and an entire Goa'uld army]]. [[ForgottenPhlebotinum This was never mentioned again.]]
*** Until ''Series/StargateAtlantis'', where the Asgard have specifically built safeguards into the transporters they installed on human ships to prevent using them in an offensive capacity.
* Hilariously spoofed in the British comedy series ''{{Hyperdrive}}''. The ruler of Queppu has a fearsome-looking Doom Ray that can disintegrate his enemies... provided they stand perfectly still for three days.
* ''TheOuterLimits'' TOS. In the episode "Soldier", the title character's weapon made the target glow and disappear.
* ''Series/DoctorWho'' has numerous instances of this technology, the Daleks having one of the more frequently used. However, the [=DeMat=] Gun used by the Fourth Doctor in "The Invasion of Time" is a special weapon. Powered by the Great Key of Time, it doesn't just disintegrate the target, it removes their entire existence from time itself.
* Subverted in the episode "Bad Wolf", where the ray used in several deadly gameshows turns to be a transmat device, but those affected generally end up as Dalek meat (as in their cells are used to grow Daleks).
** The episode "Robot" had the title character using a disintegrator gun and making a battle tank glow and disappear. When asked what the "range and power of that device is", the Doctor's answer was "the power is limitless, and as to range, it could cut a hole in the surface of the moon". See also {{BFG}}.
* An episode of ''Series/TimeTrax'' featured a villain-of-the-week who is a high-tech weapons designer from the 22nd century. Two of his specialties include a powerful beam weapon and something called a "sonic demolecularizer". It fires a sonic blast that turns people and objects into a rapidly-disappearing cloud. Like the BigBad, the villain is a [[ItsPersonal personal]] case of Darien, whose partner was killed by the villain with the demolecularizer when they first came to arrest him in the future.
* An episode of ''Series/TheInvisibleMan'' has the villain-of-the-week use a particle accelerator in this manner by throwing a colleague inside the accelerator tube before turning it on. The unfortunate victim is turned into energy atom-by-atom. Somehow, though, her energy essense survives and is visible in a certain spectrum (i.e. Darien can see it via quicksilver). The villain is HoistByHisOwnPetard when the essense of his victim is able to exert control over the physical world and trap ''him'' in the same particle accelerator before turning it on.
* In ''TheLostRoom'', the Eye has the ability to restore or disintegrate flesh. However, in order to use it, it has to be inserted into an empty eye socket. The villain manages to disintegrate a squad sent to take him out, but the aim of the Eye is terrible, as he later accidentally kills his NumberTwo this way.
* ''Series/BuffyTheVampireSlayer'': The Trio's Invisibility Ray also has this function, which Warren nearly uses on Buffy.
* ''Series/TheGoodies''. In "UF-Friend or UFO" Bill is being chased by what he thinks is an alien, but Tim won't let him in the door, so he orders Graham's robot to open it. The robot promptly disintegrates the door, so Bill can't lock it after him.

* According to the Greeks and at least one psychic from the early 20th century, [[http://en.wikipedia.org/wiki/Edgar_Cayce Edgar Cayce]], Atlantis was destroyed when they discovered machines that were essentially ancient ideas of the Disintegrator Ray.

* ''ComicStrip/BuckRogers'' is the UrExample and possibly the TropeNamer.

* ''TabletopGame/DungeonsAndDragons'' had the "Disintegrate" spell, which did ExactlyWhatItSaysOnTheTin, but only if it managed to kill the target, and is mutually canceling with [[DeflectorShields force effects]]. This made it slightly less useful than most [[GameBreaker Save or Be Screwed]] spells, but the spell was still a fan favorite, purely because of the RuleOfCool.
** Destroyed remnants also require more serious magic to bring one BackFromTheDead, so it makes sort of DeaderThanDead.
** Also appeared as one of beholders' EyeBeams (making an occasional smooth shaft or breach in the wall a hint, e.g. in ''Song Of The Saurials'' or ''The Summoning''). As of the 4th Edition, beholders can no longer do this, having more varied and balanced powers.
** In the earlier editions of the game, this was one of the special purpose powers that could be chosen for an intelligent sword with a special purpose. This effect was delivered on ''any hit'' with the weapon (in addition to its normal damage) against those that the weapon was dedicated to slaying. In fact, in the original D&D rules, this was the main power that Chaotic special purpose swords had against the Lawful beings that they were designed to slay - Lawful special purpose swords, in contrast, paralyzed Chaotic beings they were specialized against.
** As pointed out in the undead-specific source book ''Libris Mortis'', under 3.5E rules the "Disintegrate" spell is useful to fight TheUndead because it requires a constitution-based saving throw. Undead, having no constitution score, typically have low constitution saves. Also, unlike most effects that target that particular defense (which Undead typically ignore), Disintegrate works on inanimate objects (so it also works on Undead).
* ''{{GURPS}}'': Ultratech has the "Reality Disintegrator" and the more traditional "Nucleonic Disintegrator".
* ''MutantsAndMasterminds'' includes the Disintegration power where a sufficiently damaging attack can entirely remove the target from existence, preventing regeneration. A single power feat allows the user to reverse the effect at will.
* ''TabletopGame/{{Warhammer 40000}}'' has Necron Gauss weaponry, which disintegrates its target ''one molecular layer at a time''.
** The practical upshot of this being, not actual immediate disintegration of the target, but all Gauss-type weapons doing damage regardless of the target's normal resistance to weapon types. E.g. [[DeathOfAThousandCuts an infantry Gauss flayer will damage a tank despite the tank's normal invulnerability to such small weapons]].
* The first set of ''TabletopGame/MagicTheGathering'' has the Disintegrate spell as one of the staples for red magic. Its damage is limited only by how much mana you have, allowing you to either nuke a big creature or simply obliterate your opponent.

* The Commander in ''TotalAnnihilation'' has one of these. It fires a spiky ball that wipes out whatever it touches. A Krogoth won't survive, either. Nasty weapon. It consumes a metric assload of energy when fired, though, and has a very short range, so blowing up a Krogoth is likely to also blow up the Commander in the resulting nuclear blast.
* Combine dark energy weaponry in ''VideoGame/HalfLife2'' and its Episodes instantly disintegrates any enemies (with the exception of [[BadassBookworm Gordon]] [[OneManArmy Freeman]]), including the Strider's mounted cannon, a mortar-like "suppression device" and the secondary fire of the Pulse Rifle. Seems to be an innate quality of all dark energy-based technology, as even the dark energy reactors in the Citadel disintegrate anyone who touches them.
** The pulse machine guns equipped on the Striders and Gunships don't disintegrate their targets but their impact does release a small amount of the particles that come off disintegrating targets, implying that they still work by disintegration, but on a much smaller level.
* The Gluon Gun from ''VideoGame/HalfLife1'' unleashes a deadly solid blue beam of destruction, one of the only weapons able to damage Gargantuas and almost instantly killing anything else the beam touches; it is a primo example of this trope.
* Lavos, the BigBad of ''VideoGame/ChronoTrigger'', can fire off a Disintegrator Ray from its eye/maw, strong enough to [[spoiler:[[DeaderThanDead reduce the main protagonist to dust]]]]... but only in [[CutscenePowerToTheMax cutscenes]].
* The final boss of ''VideoGame/{{Iji}}'' has this as one of his attacks. If you're unfortunate enough to get hit, you're dead no matter how much life you have, and are vaporized so quickly that Iji's usual dying scream is abruptly cut off.
** And the entire bottom menu clears. All your weapons and stats disappear.
* The aptly named Disintegrator Ray in ''VideoGame/DestroyAllHumans''. It's one of the most useful weapons in the series since it deals good damage, has an excellent rate of fire, and has lots of ammo, but it has the slight drawback of leaving behind no bodies for you to harvest brains from.
* In ''VideoGame/MightAndMagic'' games, Blasters work like this if enemies use them, having a chance of Eradicating a target. [[TheComputerIsACheatingBastard (But not when you do.)]]
* ''{{Prey}}'' has a Leech weapon which, when loaded from a special terminal fires a big beam of energy at your foes, leaving a brittle, burnt, rapidly-disintegrating corpse behind.
* The Particle Cannon from ''VideoGame/{{Wolfenstein|2009}}'' (2009), which vibrates matter at such incredibly high frequencies that it instantly reduces enemies to green ash.
* Several of the experimental weapons in ''{{VideoGames/Crusader}}'' disintegrate their targets. One weapon reduces its victim into dust, another completely destroys their molecular structure and vaporizes them at once, and so on. Note that killing enemies this way prevents them from dropping weapons or ammunition or supplies.
* Averted in ''VideoGame/{{Fallout 3}}''/''VideoGame/FalloutNewVegas''. Laser and plasma weapons normally leave corpses, but fatal critical strikes by them turn your fallen enemies into piles of goo or ash.
** This is a callback to the first two games, where plasma weapons would melt foes into puddles of green goo on a CriticalHit.
*** The lasers in ''VideoGame/{{Fallout|1}}'' and ''VideoGame/{{Fallout 2}}'' would merely chop the target into a pile of steak on criticals, but plasma weapons would indeed reduce victims to a puddle of (usually red) goo. The ''Fallout 2'' Pulse Rifle had the hilarious effect of making the target's hair all stand on end, burning them to a crisp, and finally the charred corpse collapses into a pile of dust. Might also have caused XRaySparks, to boot.
*** Despite this, the goo (or dust) can still be looted for perfectly intact items (even armor).
** The alien weapons in ''VideoGame/{{Fallout 3}}'' are intended to be this (a rifle added in the "Mothership Zeta" DLC is even called the Alien Disintegrator), though their in-game effects on [=NPCs=] are similar to laser weapons.
* The [[SniperRifle disruptor rifle]] in ''Franchise/StarWars: VideoGame/JediOutcast'' and ''VideoGame/JediAcademy'' can completely disintegrate most enemies with one fully charged shot. But they'll still conveniently drop their weapons for you. The only enemies it doesn't work on are Force-sensitive ones, who are [[TheComputerIsACheatingBastard Cheating Bastards]] and can dodge the HitScan weapon (to force you to use your lightsaber).
* ''VideoGame/CommandAndConquerRedAlert2'' had at least three ways to disintegrate infantry; radiation (gloop), electricity (ash) and light (ash/dust).
** Yuri's Revenge had the Floating Disk with its Disintegrator Ray which reduced infantry to gloop with its radiation laser, while Yuri's Psychic Blast let enemy soldier's brains explode. In-game, they were reduced to nothingness by this.
** Tiberian Sun had the Laser Tower, the small anti-infantry brother of the Obelisk, which toasted enemy infantry and reduced them to dust as well.
* In ''SpaceQuest'', the slot machine fires one of these if you get triple skull & crossbones symbols, turning Roger to ashes. The Sariens' pulserays take this a step further, completely vaporizing the target.
* In ''VideoGame/KingsQuestIII'', this is one of the favorite spells your master [[BigBad Manannan]] will cast on you if you misbehave too often. ZAP, indeed!
* Various weapons in ''VideoGame/{{Crusader}}'' have this effect on the protagonist or enemies, causing them to fade away into nothingness with an echoing scream.
* In ''VideoGame/MetroidPrime 1'', the Plasma beam would disintegrate a target completely if charged, while the uncharged shot set things on fire. The Light beam did the same in ''Prime 2''. ''Prime 3'' the plasma beam returned, and when combined with the nova beam would turn a target to dust, even when uncharged if they were on fire long enough.
* In ''{{Strife}}'', you get the [[{{BFG}} Mauler]], which functions as a disintegrater ''shotgun'' with a combination energy bomb launcher.
* ''{{Amorphous}}+'' has the dreaded [[BossInMookClothing Void]] [[EldritchAbomination Eater]]. If it's not using its InstantDeathRadius attack, it will [[SuckingInLines charge energy]], then fire out a black beam which disintegrates ''anything'' it touches (including mooks, like [[KungFuProofMook Sharps]], [[DemonicSpiders Horrors, Grays]], and even the Queen and [[spoiler:[[TrueFinalBoss Razor Queen]]]]; only excluding Grinders, who just crack instead). No amount of Reactive armour will save you either.
* In ''{{League of Legends}}'', Vel'Koz ultimate ability is called ''Lifeform Disintegration Ray''.
* In ''{{Nethack}}'' black dragons [[BreathWeapon breathe]] disintegration beams which, strangely, [[ReflectingLaser bounce off of walls instead of destroying them]]. There are five ways to survive a disintegration blast: 1) [[spoiler:have equipped an item with [[AttackReflector "reflection" attribute]]]], 2) [[spoiler:wear black dragon scale mail]], 3) [[spoiler:have a shield or body armor equipped (in which case the item gets disintegrated instead of you)]], 4) [[spoiler:get disintegration immunity by [[AcquiredPoisonImmunity eating the corpse of a black dragon]]]], 5) [[spoiler:be wearing an [[AutoRevive amulet of life saving]] (which gets used up in the process)]].
* The Cow Mangler and Righteous Bison for the Soldier in VideoGame/TeamFortress2, complete with agonizing pose before being vaporized. The Engineer has his own with the Pomson 6000, and the Pyro gets his odd versions with the Phlogistinator and the Manmelter.
* ''VideoGame/FirstEncounterAssaultRecon'''s Type-7 Particle Weapon [[StrippedToTheBone vaporizes the flesh of its victims, leaving only charred skeletons]]. It's the game's go-to SniperRifle.
* Laser guns in ''VideoGame/AnotherWorld'' do this to victims.
* The N64 version of ''VideoGame/DukeNukem3D'' has a Plasma Cannon that vaporizes enemies.
* The 'Disintegrate' skill for the Wizard in ''VideoGame/DiabloIII'', It can be upgraded to be fired from both hands, make enemies explode on death, and other neat tricks. Unfortunately it has ArbitraryMaximumRange.
* ''{{Halo 4}}'' the Composer works just like this,[[spoiler: but its true function is converting organic material to data, and use it to create more Prometheans.]] The remains of its victims are just piles of dust of where they once stood.

* Many {{death ray}}s in ''Webcomic/GirlGenius'' work like this. At one point, Agatha builds one (seen in [[http://www.girlgeniusonline.com/comic.php?date=20090306 here]]) that can zap huge holes in walls (and mountains,) much to the distress of [[GeniusLoci the castle she's in at the time]].
* In ''LifeWithLamarr'', Magnusson uses the Neek Ray, which he later fits into his [[EverythingsBetterWithDinosaurs pet T-Rex's]] [[RuleOfCool eye sockets]].
* In ''Webcomic/TheOrderOfTheStick'', [[TheDragon Redcloak]] and [[TheSmartGuy Vaarsuvius]] both use Disintegrate as a go-to high-level spell for single targets. A big part of this is the fact that Redcloak especially [[RuleOfCool looks completely badass]] when using it. It doesn't always work, though.
* In ''Webcomic/EverydayHeroes'', Dr. Unpleasant has invented the [[http://www.webcomicsnation.com/eddurd/everydayheroes/series.php?view=single&ID=207406 Hyperframmiton(tm) Ray.]]
* In ''Homestuck'', [[spoiler:Lord English]] has a shoop-da-whoop beam attack that can disintegrate even [[spoiler: the souls of the dead]] wandering [[spoiler: the dream bubbles of the outer ring]] which was a terrible shock to the fans, who until that point believed [[spoiler: the dead would stick around and so nobody would "really" be killed]]
* In ''Webcomic/{{Endtown}}'' handheld disintegration rays are commonplace, and D-bombs were one of the most common weapons of the apocalypse resulting in the surface being a vast wasteland. D-rays can also be dialed back to stun instead of kill.

* One of several uses ''WesternAnimation/KimPossible'' villain Shego makes of her powers.
* ''WesternAnimation/DuckDodgersInTheTwentyFourthAndAHalfCentury'' parodies this trope more than once: First Daffy/Dodgers dares Marvin the Martian to shoot him with his disintegrating ray because Dodgers is "wearing his disintegration-proof vest." Marvin fires, and the vest is the [[ArmorIsUseless only thing not reduced to dust]]. Fortunately for Daffy, the cartoon also features a much rarer integration pistol. ''Then'', when Dodgers tries to retaliate:
-->'''Duck Dodgers:''' Ah-ha! Now I've got the drop on you with ''my'' disintegrating pistol! And brother, when it disintegrates, [[ExactlyWhatItSaysOnTheTin it disintegrates]]!
-->''(Dodgers pulls trigger, pistol crumbles into dust.)''
-->'''Duck Dodgers:''' Heh, well, what do you know, it... [[ExactWords disintegrated]].
* The Ghost Dematerializer, preferred weapon of ''WesternAnimation/FilmationsGhostbusters'', functions as one of these, but it only works on ghosts, temporarily sending them to another dimension.
* Many ''TheHerculoids'' {{villains}} had these, including the Electrode Men.
* In ''WesternAnimation/{{Futurama}}'' Professor Farnsworth sells cheap disintegrator rays that actually just teleport people a few feet away, making it appear as though they've disintegrated until anyone bothers to look.
* On ''JimmyTwoShoes'', Jimmy finds a strange egg from outer space that shoots rays like this, [[ThePollyanna not that he ever noticed]].
* ''WesternAnimation/AmericanDad:'' In the episode "I Can't Stan You," Stan fights with another CIA agent over a disintegrator, and accidentally blasts the other agent with it; apparently, Stan mistakenly believed it to be a penis enlarger until then. "That almost went horribly wrong!"
* DependingOnTheWriter, Kang and Kodos sometimes have these on the HalloweenEpisode of ''WesternAnimation/TheSimpsons''. (Kodos once vaporized [[AssholeVictim the whole studio audience]] of ''[[Main/JerrySpringer The Jerry Springer Show]]''.)
* ''WesternAnimation/BraveStarr'''s mentor Jingles Morgan used this kind of weapon. Bravestarr rightfully called it "a dangerous weapon", and admired Morgan for his ability to use it properly. [[BrokenPedestal This admiration was misplaced]]; he later discovered that his hero was wanted for ''murder'', having used to kill someone after losing his temper.

* Weta Workshop markets several SteamPunk rayguns, [[http://www.youtube.com/watch?v=PKQDqCvGjhM delightfully spoofed in their add on Youtube]].
-->''Last but by no means least is the Goliathon 83 Infinity Beam projector. Designed for the gentleman who takes his sports hunting very seriously, its infra-wave undulations will dissolve 7/9th's of an African elephant in ten Earth seconds.''