''Defiance'' may refer to:

* [[Film/{{Defiance}} A 2008 film]] starring Creator/DanielCraig
* [[Series/{{Defiance}} A 2013 TV series]] on Creator/{{SyFy}}
* [[VideoGame/{{Defiance}} A 2013 MMO]] ThirdPersonShooter game which is a tie-in to the TV series
* {{Defi|ed}}ance of a {{trope}}.

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