[[quoteright:300:[[VideoGame/BioShock1 http://static.tvtropes.org/pmwiki/pub/images/bioshock_tk_plasmid_ad_7354.jpg]]]]
[[caption-width-right:300:[--Warning! May cause [[FantasticDrug Addiction]], BodyHorror, and/or PowerHigh.--] ]]

->''[[MyDadCanBeatUpYourDad My daddy's]] [[SuperIntelligence smarter]] than [[UsefulNotes/AlbertEinstein Einstein]], [[SuperStrength stronger]] than [[ClassicalMythology Hercules]], and [[PlayingWithFire lights a fire]] [[FingerSnapLighter with a snap of his fingers!]] Are you as good as'' my ''daddy, mister? Not if you don't visit the'' Gatherer's Garden, ''you aren't!''
-->-- Gatherer's Garden advertisement, ''VideoGame/BioShock1''.

The biological counterpart to {{Cyborg}}ing: instead of altering humans to add machine parts, the geeks in the lab-coats change the flesh, blood and DNA.

Genetic Engineering and stem cell research opens new avenues in the way science and SciFi writers can create modified humans to suit any environment. You could think of them as artificially created {{Mutants}}, but "artificially created" is the key to the definition. And we mean created on purpose, not by freak accident like [[Comicbook/IncredibleHulk being bombarded with gamma radiation]] or other exposure to GreenRocks.

On the mild end, this can entail things that, if current medical science keeps trending the way it does in RealLife, may not sound all that fantastic in a few decades: limb grafts, biological prosthetics and less visible gene mod enhancements that make people smarter, stronger and better at stuff. Further down the fantastic scale you start to get genetic [[StockSuperpowers superpowers]], quick and easy drastic cosmetic changes from plastic surgery on up (want green skin and spots? No problem!), extra limbs and stuff that makes humans look a lot more like aliens than most HumanAliens.

Can be combined with {{Cyborg}}ing for even more body mod fun. Certain types of FunctionalMagic may accomplish the same thing but many or most of them are better listed under MixAndMatchCreature or HybridMonster, and of those remaining, should be looked at with ClarkesThirdLaw in mind. Is a newer trope than cyborging because GeneticEngineeringIsTheNewNuke (and shares some but not all examples with it). Also see OrganicTechnology, LegoGenetics, MagicGenetics, SuperpowerfulGenetics, MixAndMatchCritters, ArtMajorBiology, BioPunk, and its SuperTrope, {{Transhuman}}.

----
!!Examples:

[[foldercontrol]]

[[folder:Anime & Manga]]
* ''{{Appleseed}}'' has "bioroids", {{Artificial Human}}s with genetically suppressed aggressiveness.
* ''GhostInTheShellStandAloneComplex'' also has a bioroid, [[spoiler:Proto]], in the second season.
* ''{{Claymore}}s'' use something like Graft Flesh from D&D for reproduction.
* The Millennium Organization in ''{{Hellsing}}'' uses surgical procedures to turn Nazi soldiers into vampires in order to better their odds at [[TakeOverTheWorld world domination]].
* Absalom in ''Manga/OnePiece'' is a freakish mixture of animal parts all sewn to his previously normal human body. You can't see most of it normally except for his lion's mouth. Sadly for him, biology and physics don't work the same in this world, so Sanji is much stronger than the [[BearsAreBadNews bear muscles]] comprising Absalom's limbs.
* Coordinators and Extended in ''Anime/MobileSuitGundamSEED'' and ''Anime/MobileSuitGundamSEEDDestiny''. The former are humans genetically engineered to be peak mental and physical specimens of the human race, the latter are ordinary humans turned supersoldiers through years of mental conditioning and carefully-administered drug regimens.
** The Human Reform Legaue in ''[[Anime/MobileSuitGundam00 Gundam 00]]'' also uses genetic engineering to create SuperSoldiers with telepathic ability. Such a project produced Allelujah and Soma.
* In ''{{Guyver}}'' the entire business plan of the Chronos[[CosmopolitanCouncil Corporation]] is to "optimize" humans into monstrous Zoanoids.
* In ''Manga/WildFangs'', Syon is created in attempt to make more Marked Ones. Besides being created via artificial insemination, he was continually having pieces transplanted onto him leaving huge raw scars where the natural markings would ideally be.
* Tsukune and [[spoiler:Hokuto]] from ''RosarioToVampire'' are humans who have been [[SuperhumanTransfusion infused]] with the blood of [[OurMonstersAreDifferent monsters]], and have gained some of their powers--and some [[WithGreatPowerComesGreatInsanity mental instability]].
* Many Bishokuya from ''{{Toriko}}'' are infused with Gourmet Cells which cause mutations giving them special powers and limited AdaptiveAbility. Eating food that is compatible with them will cause them to "[[NextTierPowerUp evolve]]". This isn't without risk since Gourmet Cells burn energy at an alarming rate, forcing those who have them to be {{Big Eater}}s. A few people were born with Gourmet Cells instead of having them infused later, such as Midora.
** Chapter 259 reveals that [[spoiler:the Earth itself was infused with Gourmet Cells by a meteorite. The "Human World" is the original Earth and "Gourmet World" is what the Gourmet Cells created.]]
* In ''Anime/YuGiOhGX'', Kenzan's DNA was accidentally spliced with that of a dinosaur sometime in the past when he suffered broken bones at a paleontological dig, and doctors mended them with dinosaur bones at hand. This enables him to somehow access primal, bestial powers when angered or excited, at which point [[HellishPupils his eyes become reptilian]] and he can gain a serious HeroicSecondWind. It also renders him impervious to the corrupting power of the Light of Ruin. (Sure, it really [[ArtisticLicense doesn't make sense]] but little in the show does.)
* Manga/SnowWhiteAndSevenDwarfs revolves around "tekigousha," people who've obtained special abilities (primarily of the BlessedWithSuck variety) by undergoing human experimentation. Virtually every major character is a product of said experimentation.
[[/folder]]

[[folder:Comic Books]]
* ''ComicBook/RogueTrooper'' centres around the last surviving Genetic Infantryman out to avenge his comrades.
* In ComicBook/TheMighty, Alpha One [[spoiler: Had been kidnapping humans for years and experimented on them to give them the same super powers as him. Most of them turned into monsters.]]
* In the story "Bats in My Belfry", in ''Series/TalesFromTheCrypt'', a man who was going deaf received an ear-canal transplant from a bat. The same back-alley surgeon who performed this impossible operation had previously given one of the protagonist's friends an eye-transplant from a panther.
* ''ComicBook/IronMan'' foe Ezekiel Stane augmented himself to be a biological version of Iron Man. He can use his own body's energy reserves to fly and generate repulsor blasts, but needs to consume a very high calorie goo to avoid starving himself to death after using his powers. To use his full powers, Ezekiel also needs to wear a suit designed to vent excess body heat to avoid burning himself up.
* In ''Comicbook/{{Uber}}'', the mysterious "Wotan's Blood" kills and/or horribly mutates most people but can transform others into the superhuman "Ubers". Depending on the potential of the candidates and the follow-up activation procedures, the results can be radically different. The rarest and strongest Ubers are the "Battleships" who can wipe out dozens of lesser Ubers with ease.
[[/folder]]

[[folder:Fan Works]]
* In ''FanFic/AeonEntelechyEvangelion'' before the First Arcanotech War there was a genefixing procedures that modified humans. After the Nazzadi joined, due to their existential angst by being an manufactured race with FakeMemories they put a stop to any transhuman experiments. By the time the fanfic starts, genefixing is slowly resurfacing.
* In ''FanFic/Warhammer40000Trouble'', all the ('''[[ChildSoldier teen]]''') humans are given BioAugmentation. Instead of painful surgery or something, they're only given drugs and manipulated diets, and they become stronger via TrainingFromHell and LevelGrinding. [[CompetenceZone The best result achieved when they're in puberty (14-20 years)]]. Elites are those who can stand heavier training, therefore higher PowerLevels. Result usually break into three categories:
** ''Soldiers'' = Simply [[BadassNormal stronger and faster]] (most people tends toward this, boys and girls alike). All of them Join [[RedShirtArmy Guardsmen]].
** ''Sisters''= Girls weaker than the female Guardsmen, but able to synchronize with PoweredArmor efficiently (without Black Carapace).
** ''Operators''= Incredibly high perception, G-tolerance, and motor control, resulting [[InstantExpert almost-instant]] AcePilot.
* In ''Fanfic/MassEffectHumanRevolution'' mankind uses this to LoopholeAbuse around their self-imposed anti-cyborg rulings. The genemods given to the average Alliance soldier makes them "only" peak human, but more potent ones exist - Jules Leng, being TheDragon to the CorruptCorporateExecutive running the most advanced MegaCorp in the trade, has bioaugs that grant him CompellingVoice, DeflectorShields, HealingFactor and InvisibilityCloak.
* ''Fanfic/TheHeadhunt'': The [[TheMafia Motta crime family]] has been known to get its soldiers genetically enhanced on independent fringeworlds like Adigeon Prime where such augs are legal. Dul'krah also reveals that his entire species is genetically enhanced to be resistant to disease and radiation and "able to subsist on materials that most would not even consider edible," which they believe dates back to the aftermath of their self-inflicted ApocalypseHow.
* Runs rampant in ''Fanfic/NoGodsOnlyGuns'' thanks to unscrupulous {{MegaCorp}}s experimenting on the human genome - with the side effect of inducing [[HumanityIsInsane mental instability in a large part of the human population.]] The process is explicitly described as "pummelling their DNA into submission."
* Starting to come to the fore in ''Fanfic/ChildOfTheStorm'', with both the MCU and Mainstream versions of Extremis being referenced (the latter is a refinement of the former), as well as the Infinity Formula.
* Played with in Fanfic/AlabasterOrchestra, with Ichigo [[spoiler: having his Shinigami side being purged from him after getting captured by the Vandenreich.]]
[[/folder]]

[[folder:Films -- Live-Action]]
* ''RepoTheGeneticOpera'' has the realistic version, the most fantastic being Blind Mag's hologram projecting eyes.
* In ''[[Film/TheBourneSeries The Bourne Legacy]]'', Outcome agents are retrovirally engineered to enhance their physical and mental abilities.
[[/folder]]

[[folder:Literature]]
* Successful bio-augmentation exists in the world of the ''{{Literature/Alterien}}'' series. In fact, many variations of bio-augmentation is what goes into the creation of super soldiers. Other uses go to treating civilians as well.
* ''{{Duumvirate}}'' has [[PsychoElectro electroplaques]], [[MultiArmedAndDangerous quadbracchalism]], [[PlayingWithFire combustive gases]], and other things as "extras". The new ''basic'' humans have regeneration, super strength, and super speed.
* The ''VattasWar'' series has "humods", modified humans that use combinations of biotech and cyborg tech in a way that they practically stand in for the series' AbsentAliens. A tongue that can check the authenticity of precious gems? Extra-sensitive tentacle hands? Colored skin? You can have all that.
* In LoisMcMasterBujold's Literature/VorkosiganSaga books:
** The Cetagandans are extremely into genetic engineering on themselves. Especially the Haut caste.
** On Jackson's Whole we see body guards who have enhanced strength and reflexes, at the cost of shorter lifespans. They're also the ones who made Taura the super-soldier, and Baron Ryoval would make you a slave to satisfy any of your depraved desires, for a price.
* The novel ''Literature/BloodMusic'', winner of a HugoAward and a NebulaAward, is a GoneHorriblyWrong example: a scientist creates biological computers, each potentially as smart as a human from lymphocyte cells then injects them into himself. [[AIIsACrapshoot They attain self-awareness]]. Chaos ensues.
* Along with rampant xenophobia, a rigid caste system, a hatred of nonorganic technology, and institutionalized, religious masochism, this is the [[NewJediOrder Yuuzhan Vong]]s' "thing". Chopping off fingers or limbs to replace them with specifically-created animal bits is a sign of status; if their bodies then reject the new additions, it leads to a major drop in status.
* This trope is the foundation of Scott Westerfeld's ''Literature/{{Uglies}}'' Trilogy.
* In Orson Scott Card's "[[Literature/EndersGame Shadow]]" series, a rogue scientist alters the DNA of 24 fertilized eggs to create superhumans, with a possible goal of replacing humanity. They're highly intelligent from an impossibly young age; the only downside is that they [[spoiler:grow so large their bodies can't take the stress and they die by the age of 20]]. The experiment's only survivor is [[spoiler:Bean]], and he does his best to keep his children from inheriting it.
* This trope is also the foundation of James Patterson's ''MaximumRide'' Series.
* Further toward the fantastic end of things, we have the Bred in ''Literature/TheSiranthaJaxSeries''. They're engineered at birth to be better than average humans -- faster, stronger, more graceful, more beautiful. They even have at least one superpower -- [[spoiler: regeneration]].
* Tons of it in the ''Literature/CouncilWars'' series, as part of the general MagicFromTechnology nature of the milieu.
* Used in the ''Literature/HonorHarrington'' series. The depiction is fairly realistic, with such things as [[RequiredSecondaryPowers the titular character suffering malnutrition]] when her HyperactiveMetabolism isn't kept fed. The series also features a fight against [[MoralEventHorizon "genetic slavery"]].
* It's amazing how many fantasy stories let the protagonist to absorb his opponent's abilities simply by [[YourVampiresSuck drinking their blood.]]
* In ''Literature/{{Spin}}'' there is the Fourth Age, extending one's life and allowing to install different abilities on the human.
* The ''Sauron Cyborgs'' in Jerry Pournelle's [[CoDominium future history cycle]] are created through bioaugmentation rather than ''chop and replace''.
* This is the [[PlanetOfHats Hat]] of the planet Prometheus in GeorgeRRMartin's "Thousand Worlds" short stories. Through genetic engineering, the Prometheans are bigger, stronger, faster, and mentally they are always "three steps ahead", to quote a Promethean character from "Nightflyers". It's theorized that they live longer than non-augmented humans as well.
* Creator/GregEgan's ''Literature/{{Quarantine}}'' focuses heavily on neural mods that alter people's thought processes - for instance, ''Sentinel'' allows a person to stay focused and alert through long periods of inactivity, and ''Boss'' allows a person to play with their circadian rhythm, meaning that they can fall asleep at-will or set aside the effects of fatigue. The protagonist in particular used a mod that dulls emotions to keep the mind clear for rational/tactical thinking (standard issue for police officers) to not be bothered by his wife's death, which is implied to be a semi-common form of abusing mods. More conventionally, the book also mentions that most southern Australians have black skin to combat the destruction of the ozone layer.
* Rob Grant's ''Literature/{{Colony}}'' has backstreet grafters, who can (illegally) replace existing organs and add extra body parts. A prostitute offers one character a handjob with a hand with a vagina in the palm.
* Jeff [=VanderMeer's=] ''[[Literature/{{Ambergris}} Finch]]'' features the Partials, people who have deliberately allowed parts of their bodies to be overtaken by beneficial fungus infections and replaced one of their eyes with a "fungus camera", in order to become [[TheQuisling Quislings]] for the Graycaps.
* Done with almost terrifying thoroughness by the "Change" syringes in ''Literature/BeggarsInSpain''. In addition to delivering the Cell Cleaner, which destroys any bearers of non-native DNA (from bacteria to cancer), it modifies the human body to be able to liquefy and absorb certain forms of matter, and adds organelles capable of photosynthesis and fixing nitrogen directly from the atmosphere. If mouth food is not available, a Changed person can lie on soil and in sunlight for half an hour and obtain all the energy they need. "[[TheSingularity You are now autotrophic]]."
* In the web-novel ''Literature/{{Domina}}'', something called the "toy maker" lets people modify their bodies relatively easily. It's described as "like stem cells, but without the moral implications." The products are called "toys," and are split into cosmetic "cosmos" and functional "buffs."
* The Susan Gates novel ''Dusk'', which centered on a girl engineered with hawk DNA
* In Creator/RobertSilverberg's story "At the Conglomeroid Cocktail Party", genetic engineering is such a common and casually-regarded thing in the far future that people actually hold "fetus parties" where they invite the guests to come up with the best design for the hosts' future offspring.
* "Pure" boys and some girls living in the Dome undergo "coding" (enhancing their speed, strength and intelligence) in Julianna Baggott's sci-fi novel ''Pure''.
* In Creator/RogerZelazny's ''Literature/CreaturesOfLightAndDarkness'', this is common on the human worlds, especially Blis, where we meet a wrestler with four arms, and Megra of Kalgan has such enhanced strength that she can only trust the strongest of men to survive her lovemaking.
* In ''{{Neuromancer}}'' Wintermute replaces Case's failing pancreas and liver with bioengineered ones that make him ImmuneToDrugs, he then spends much of the book looking for something that can get him high.
* In Creator/RobertReed's ''Literature/GreatShip'' universe, the [[HumanSubspecies Remoras]] are constantly bombarded by interstellar radiation due to them living on the outer hull of the [[PlanetSpaceShip Great Ship]], which causes rampant mutations. The Remoras use technology to cultivate the mutations into forms they consider useful or beautiful - such as being able to see further up the visual spectrum by [[EyelessFace replacing their eyes with photosensitive hairs]].
* ''Literature/TheMortalInstruments'': [[spoiler: Valentine unknowingly added angel's blood to Clary before she was born.]]
** [[spoiler: He also added angel's blood to Jace before he was born, through the naivete of his birth mother Celine Herondale.]]
* In the MonsterBloodTattoo series, people do various forms of this; the most disturbing ones augment their senses to the point they have to wear special helmets to help direct things so they don't go insane from sensory overload. Unusually, this series is set not in the future, but in a world resembling a magical version of Napoleonic Europe.
* ''Literature/TheUltraViolets'' got their superpowers from accidentally being exposed to Helitropium, a substance capable of genetically altering any living thing on planet Earth.
* In ''Literature/AConfusionOfPrinces'', Princes have a combination of this and {{cyborg}} parts.
* ''{{The Witcher}}'' has [[CursedWithAwesome mutations]]such as faster reflexes, higher regeneration, more durability, higher tolerance to toxins, immunity to diseases and control over the body to a incredible degree (such as controlling the widening or shrinking of the pupil). However, this comes at the price of [[BlessedWithSuck infertility]]. Also, most aspiring witchers die due to the horrible side-effect and high mortality rate.
[[/folder]]

[[folder:Live-Action TV]]
* The ''Franchise/StarTrek'' universe does not indulge in this to a great deal but it's reasonable to believe they have the technology for it, given that when someone needs to pass as, say, Romulan or Cardassian (or Cardassian posing as a human in one case), they can drop into sick bay for some easy plastic surgery and genuine pointy ears.
** TheFederation [[NoTranshumanismAllowed banned it]] due to having the genetic engineering equivalent to a RobotWar. Earth's early attempts created Khan and his supermen, superior in mind and body but too aggressive. Having been engineered to be superior to ordinary humans, they felt that they should ''rule'' the ordinary humans. They ended up starting the Eugenics Wars before being defeated and exiled as {{Human Popsicle}}s. This causes a major problem for [[Series/StarTrekDeepSpaceNine Dr. Bashir]] when he gets found out. Genetically enhanced humans were eventually dubbed "Augments".
** The United Earth had a ban on genetic enhancement before becoming founding the Federation, as mentioned on Enterprise. However, other species are not discussed. The question of whether a society that regularly used genetic engineering could join the Federation is not discussed.
** Bashir would later be charged with the care of a quartet of...slightly off Augments in "Statistical Improbabilities." Nicknamed the "[[FanNickname Jack Pack]]" after their nominal leader, the four are able to postulate how the Dominion War will end... and then try and facilitate the Federation's surrender to prevent the needless waste of life.
** Despite the ban, one ''The Next Generation'' episode had the Federation allow a research station to develop an "ideal" human species. With long lifespans, improved intelligence, youthful appearance, telepathy, and an advanced immune system, they were the scientist's every dream. Almost.
** On the other hand, The Dominion, Federation's EvilCounterpart, is a huge genetic engineering society. Jem'Hadar were created from nothing[[note]]Or, according to some fan theories, from modifying the Tosk (who have weaker versions of the special abilities demonstrated by the Jem'Hadar), themselves genetically engineered.[[/note]], Vorta bred from some other form; and it's stated that [[spoiler: The Founders were once humanoids but genetically engineered themselves into shape shifters. It is even supposed that their close-mindedness is the price they paid for their new body abilities.]]
** The Suliban on ''Series/StarTrekEnterprise'' obeyed a mysterious figure from the future, known to fans only as "Future Guy" since his identity was never revealed, in exchange for genetic upgrades.
* ''Series/BabylonFive'': Vorlons bioengineered various younger races to have telepathy. The Psi-Corps does extensive experimentation to allow telepaths greater abilities. Gill implants exist that allow the recipients to breathe in atmospheres they usually can't.
* A regular character in ''SeaQuestDSV'' had himself implanted with gills to allow him to breathe underwater. Apparently, he is also able to survive at great depths.
** Also, there is a race of [[FunWithAcronyms GELFs]] (Genetically-Engineered Life Forms), bred to be {{supersoldier}}s. They eventually force [=UEO=] to recognize them as equals. They can breathe in rarefied atmosphere.
* The ''Series/RedDwarf'' episode ''DNA'' had a DNA modifier which would allow a user to change their genetic structure. When the crew encounter the ship it was on, they find a man with three heads. Kryten accidentally becomes human, Lister becomes a chicken, a hamster and a foot tall "Man-Plus" (Essentially Lister crossed with Franchise/RoboCop) and a mutton vindaloo becomes a mutant vindaloo-based creature that can only be killed with the application of lager.
* {{Series/Heroes}} has a red formula that gives people a seemingly random ability.
* In ''Series/{{Firefly}}'', this appears to be the goal of [[SchoolForScheming the Academy]], which gives people PsychicPowers, mental conditioning, and combat training to create superhumanly powerful assassins.
* In ''Series/{{Supernatural}}'' the [[Characters/SupernaturalSpecialChildren Special Children]] gain psychic powers after they were fed demon blood as an infant.
* In ''Series/OrphanBlack'' Olivier has had a tail transplanted onto himself, which he seems quite proud of. More generally, the neolutionists are believers in this.
* The villainess in the ''Series/DoctorWho'' story "The Two Doctors" is an Androgum woman who has been "augmented" to the point where she has reached "mega genius level". However, both the Second and Sixth Doctors have misgivings about this, saying that, regardless of what has been done to her mind, the fact that Androgums are inherently treacherous and self-serving cannot be altered.
[[/folder]]

[[folder:Tabletop Games]]
* In {{Mortasheen}}, as you level up, you can improve your {{Mons}} via this.
* ''TabletopGame/{{Warhammer 40000}}'', [[SpaceMarine Space Marines]], need I say [[http://wh40k.lexicanum.com/wiki/Creation_of_a_Space_Marine more?]]
* ''TabletopGame/DungeonsAndDragons'' has the "Graft Flesh" feat and several variations that allow the altering of a creature's biology.
** In the ''DarkSun'' setting supplement ''The Windriders of the Jagged Cliffs'', players are introduced to living "life shaped" items that could be implanted in living beings.
* ''Cyberpunk203X'' includes a sea-faring tribe that uses genetic manipulation instead of cybernetics.
* ''TabletopGame/{{Shadowrun}}'' has bioware (biological implants that enhance the recipient's abilities) as well as genetic augmentations. They aren't nearly as cool as and more expensive than cybernetic implants, but they do cost less [[CyberneticsEatYourSoul essence]].
** The one that shows up all over the place, especially in the novels, is the Supra-Thyroid Gland. Better, stronger, faster... all in one easy operation. The [[BigEater side effect]] is fun, too.
* Approximately half of ''{{GURPS}}: Biotech'' is devoted to this.
* A common trope in the StarDrive setting, especially for Thuldan characters.
* MagicTheGathering:
** Take BioAugmentation, add a generous dose of HollywoodCyborg and BodyHorror, and you've got [[MagicTheGathering Phyrexia]] [[{{Metaphorgotten}} and a couple of spare livers]].
** The Simic Combine has this as one of their premier products, allowing customers to add various augmentations with Cytoplasts (such as give a normal-sized human a giant's strength). Unfortunately Momir Vig had ulterior motives for these...
* In ''TabletopGame/HunterTheVigil'', The operatives of the Cheiron Group keep up with supernatural creatures by abducting them, [[TheyWouldCutYouUp cutting them apart]], and grafting bits of what make them special into their own systems.
* The [[YouDirtyRat Skaven]] supplement ''Children Of The Horned Rat'' for WarhammerFantasyRoleplay has several sections on body augmentation - either technological, using [[{{Cyborg}} bionics or powered frames]] built by [[GadgeteerGenius Clan Skryre]] and done willingly, or actually warping flesh (usually that of prisoners) and melding creatures with weapons or mechanisms to produce horrific shock troops as practiced by [[BodyHorror Clan Moulder]]. Moulder members also tend to "improve" themselves as well, with extra limbs or massively altered metabolisms, with roughly the same results.
** For a period, there was a Skaven-specific GaidenGame of Rat Ogre Pitfighting on the Games Workshop website, dedicated to the deranged craft of Clan Moulder. The entire point of the game was to do this kind of stuff to your "pets" and hurl them against the other players.
* ''GURPS TranshumanSpace'', obviously. Implanted bioengineered organs ranging from straight-up replacements to lungs that allow you to breathe Mars' atmosphere, and Proteus [[NanoMachines nanoviruses]] that can rewrite DNA in living cells ("soft" changes only though).
* ''EclipsePhase'' again. In this RPG, changing bodies is done so often that a body is referred to as a 'sleeve'; all it takes is for someone to extract your "Cortical Stack" (which makes a backup of your mind once per second) and plug it into a new sleeve. Most biological sleeves, aside from non-engineered humans (called ''Flats'') are immune to aging, immune to all natural diseases including cancer, and can even regenerate lost limbs over time.
[[/folder]]

[[folder:Toys]]
* The Great Beings in ''{{Bionicle}}'' do this to many of their experiments, including giving the Vorox and Zesk [[BewareMyStingerTail tails]].
** The Order of Mata Nui has been known to do this as well; for example, they are known to have experimented on Ehlek's race, but just what they did to them is unknown.
[[/folder]]

[[folder:Video Games]]
* The Splicers in ''VideoGame/BioShock1'' are this GoneHorriblyWrong, quick and easy gene modification for superpowers at the cost of sanity. The plasmids/tonics that cause the most mental damage are the cosmetic plasmids (which the player can't use), which were ''designed'' that way.
* ''VideoGame/DeusEx'' has the protagonist, his brother and the [[EvilCounterpart two main antagonists]] equipped with [[{{Nanomachines}} "nano-augmentations"]]. In [[VideoGame/DeusExInvisibleWar the sequel]], this technology is much more widespread.
** In the [[VideoGame/DeusExHumanRevolution prequel]], the vast majority of augmentation are still of [[{{Cyborg}} the mechanical sort]], as nanomachine-based augmentation isn't even being tested yet.\\
That said, a sidequest does reveal that bio-augmentation tests performed on infants (presumably not using nanomachines) was the reason [[spoiler:Adam's body can accept augmentation without the use of any drugs]], and the ending implies [[spoiler:what was recovered of this technology from Adam's body was used to create the Denton brothers.]]
* The Genome Soldiers of ''VideoGame/MetalGearSolid'' are enhanced by gene therapy with the genes of Big Boss to have augmented senses and reflexes.
** The entire first game in the Solid series is a {{Deconstruction}} of gene therapy (among other things). The end of the game includes a character noting that having the genes necessary to succeed means nothing if you don't have the mentality. And Snake himself is supposed to be a living example: despite receiving "all the recessive genes" and being an inferior clone of Big Boss, he is perhaps the greatest soldier in the world.
* In ''Franchise/{{Metroid}}'', Samus gets this a lot. She first was augmented with Chozo [=DNA=] as a kid to help her survive on their planet after the race adopted her. [[VideoGame/MetroidFusion Later on]], she's also transfused with Metroid [=DNA=] to save her life after being infected by the X-virus.
* This happens quite a lot in ''VideoGame/{{Geneforge}}'', as skill canisters manufactured by the titular Geneforge can enhance the abilities of anyone who absorbs their contents by re-writing their genetic structure. However, [[spoiler:WithGreatPowerComesGreatInsanity...]]
* ''VideoGame/EVEOnline'':
** The mysterious Jove race became masters of gene manipulation and other bioengineering, transforming themselves into emotionless, quasi-superhumans. It's since bitten them in the rear, as they suffer from a degenerate disease that threatens to wipe them out.
** The Blood Raider Covenant runs an ample research of improvement of the human body through transfusions of modified blood that, among other examples, grants its citizens reduced aging, improved inmunological system and enhanced physical fitness, making their troops rival even Sansha's Nation [[{{Cyborg}} True Slaves]] in combat effectiveness. Combined with a populace-wide public blood transfusion system (which has its basis on their ritual of "Blooding", main axis of their cult, the [[{{ReligionOfEvil}} Sani Sabik]]), the Covenant's citizens enjoy a far more healthy life than those of even the main Empires. Unfortunately for outsiders, that means they might get their ship captured and themselves dragged to "Blood Farms" for having their blood used for the rituals, research, or even nourishment of the Blood Raiders.
* Genetic enhancement is fairly commonplace in ''Franchise/MassEffect'', but is strictly regulated by Council law. Enhancing existing abilities is legal; adding new ones is illegal. Alliance soldiers routinely undergo genetic enhancement upon entering the military, and almost all children are screened before or just after birth and provided treatments to fix genetic defects. In addition, there now exist "designer babies", children of the wealthy that were engineered from the ground up to be better than normal humans. In some places they're the equal of any other human, in others they're regarded as little more than property.
** ''Mass Effect 2'' squadmate Miranda Lawson is one of these "designer babies", [[CursedWithAwesome and shows why it's not such a good idea]]. You can also pick up a "krogan retrovirus" upgrade, which alters the genetic code in squadmate Grunt to increase his health.
* ''VideoGame/{{Halo}}'':
** The SPARTAN-II supersoldiers, at 14, underwent a laundry list of enhancements that made them physically and mentally superior to all other humans--those that survived the process, that is. Even so, [[{{Asexuality}} damage]] remains in that they lack interest (and, through implication, ability) in sex.
** The list of enhancements to SPARTAN-[=IIIs=] is even longer, as their instructor, a SPARTAN-II, got tired of watching his students get slaughtered in suicide missions and added a few illegal enhancements to make them highly resistant to pain.
* In the Compilation of ''VideoGame/FinalFantasyVII'', various kinds of SuperSoldiers are created via bioengineering and ruthless human experimentation.
** The most extreme case is Sephiroth, who is technically human, but with truly bizarre DNA since he was altered in the womb with Jenova cells and infused with mako energy.
** Genesis and Angeal from ''CrisisCore'' were products of Project G (a less successful Shinra research project that competed with Project S which produced Sephiroth) which also involved the use of Jenova cells and mako in developing fetuses.
** [=SOLDIERs=] such as Zack Fair and experimental subjects such as Cloud Strife are the result of modifying humans with both Jenova cells and Mako.
** Vincent Valentine was originally human, but was modified by both Hojo and Lucrecia Crescent into a deadly shapeshifter.
** Also from ''DirgeOfCerberus'', the Deepground soldiers and Tsviets were results of various bioweapon experiments.
* The ''FinalFantasy'' franchise actually first utilized this trope in ''VideoGame/FinalFantasyVI'', where TheEmpire bio-engineered [[BigBad Kefka]] and Celes to be magic-wielding SuperSoldiers by implanting the genes of magical Espers. The process turned Kefka into a PsychoPrototype MonsterClown, but it was refined in time to give Celes magic without any downsides (though a cut plot point from the game would've made Celes unstable as well). Then she proved just as problematic as Kefka, but for [[HeelFaceTurn different]] [[PhlebotinumRebel reasons]].
* In the expansion pack to ''VideoGame/XCOMEnemyUnknown'', called Enemy Within, you have the option to upgrade your troops with gene mods to increase their combat potential. The modifications include, among others, increased muscle density, which allows them to jump to rooftops, a secondary heart, which prevents them from dying instantly when critically wounded, and mimetic skin, which let's them blend with the environment.
* ''VideoGame/CivilizationBeyondEarth'': The Purity affinity is nominally anti-transhuman, but still partake in some basic genetic modification to improve lifespan and resistance to disease. It is the Harmony affinity, however, who take genetic modding into transhuman territory, incorporating alien DNA into their own and allowing them to empathise better with alien lifeforms and breathe otherwise deadly Miasma. High-tier Harmony foot-soldiers are basically [[HalfHumanHybrid Human-Alien hybrids]].
[[/folder]]

[[folder:Web Comics]]
* In ''{{Drowtales}}'' this is what the all-female Jaal'darya clan is (in)famous for. Well, this and OrganicTechnology.
* ''{{Spacetrawler}}:'' Yuri gets part of an Eeb brain implanted into her own, in order to gain greater technological understanding and limited telekinesis. And she gets cat ears, because she wants to be a CatGirl.
* The K-Series soldiers in ElfBlood were designed before birth to have bodies ultra-compatible with MagiTek implants. They were quite successful.
* In ''Webcomic/JetDream'', Virus-X gives T-Girls enhanced strength, agility, and endurance in addition to [[GenderBender its most obvious effect]].
* Many characters in ''Webcomic/SchlockMercenary'' get various strength and resiliancy boosts, due to their occupations as soldiers or mercenaries. More than a few characters end up getting full-body makeovers (turning a very runtish character into TheBigGuy, for example). Later on, some characters learn too late that this process can [[BodyHorror turn them]] into unwitting [[TyphoidMary bio weapons]].
* ''Webcomic/AmongTheChosen'' has quite a few heavily modified characters, but the technology tends to be so advanced as to blur the line between this and {{Cyborg}}s.
[[/folder]]

[[folder:Web Original]]
* This is the point of Pelvanida Base in ''DarwinsSoldiers''.
* In NewVindicators, this pops up with the Primes, man-made Neo-Sapiens (or super powered mutants), with powers of their genetic donors (though not always willing). In one case, cunning terrorists buy samples of this Prime technology and have it used by their duplicating leader to impregnate several women-leading to supers not only with doctored in super powers, but the man's own duplicating power as well.
* The Bioborgs of ''OrionsArm''.
* The Coalition soldiers (Ourkind) and several of the protagonists are this in ''UnlikelyEden''.
* This is a common way of gaining superpowers in the ''GlobalGuardiansPBEMUniverse''. [[EvilOverlord Lord Doom]] even bio-engineered a raft of children to serve him as [[SuperSoldier super soldiers]].
* Literature/WhateleyUniverse: It's how Delta Spike went from a nerdy teen inventor to a super-strong energy blaster with the MostCommonSuperpower. She was experimented on by the dreaded Dr. Pygmalion. The doc's other experiments have all that, plus they are his mindslaves.
* Happened to [[ShadowhunterPeril the Architect]] in 1943 at the hands of Nazis, but the actual events of this time period take place on a different storyline called Upworld, Downworld. He was part of a highly unstable project by Nazi Germany to create a SuperSoldier race of Nazis. Because of the danger this would theoretically pose to human lives, they used prisoners in the concentration camps. They infused demonic steroids within his body. The result augmented his muscular strength and turned his bones into a kind of living metal. [[TooDumbToLive Naturally after discovering his new abilities, he killed the people who slaughtered his family and then escaped.]]
* Planet Shield from ''Literature/{{Phaeton}}'' do this all of the time, though its mostly done with mindless clones who they then control with remote stations.
* Panacea of ''Literature/{{Worm}}'' has this as a superpower. She can exert complete control over the physiology of any living thing she touches. She mostly uses it [[HealingHands to heal people]], but the possible applications are pretty much endless.
** Bonesaw is a [[GadgeteerGenius tinker]] who specializes in the biological, and it's expressed mainly through this trope, both on herself and [[BodyHorror her victims]].
* Common in Roleplay/VoidOfTheStars, nearly every species practices it in some way.
** Aside from the humans. It's illegal to genetically modify one of them.
* In ''Franchise/{{Noob}}'', this is the advantage given to Empire neogicians compared to those from other factions according to the webseries and novel. The one from the main guild is known to have gotten SuperSpeed, while the advatage gained by the other ones are currently unknown. The ''Literature/{{Neogicia}}'' SpinOff focuses on Empire neogicians. The FirstPersonPerspective protagonist is shown to have gotten the standard SuperStrength, HyperAwareness and much more rare {{Telekinesis}}.
[[/folder]]

[[folder:Western Animation]]
* Alpha, a recurring villain on the ''WesternAnimation/MenInBlack'' cartoon, collected alien body parts which he stuck onto himself.
* In ''WesternAnimation/TheSpectacularSpiderMan'', Kraven the Hunter is created by Sergei Kravinoff having himself injected with an "electrolized" [[LegoGenetics DNA formula]] of various jungle cats, turning himself from a BadassNormal, to a formidable feline supervillain.
* ''WesternAnimation/BatmanTheAnimatedSeries'' has Manbat. Unfortunately, WithGreatPowerComesGreatInsanity.
* ''WesternAnimation/TransformersAnimated'': This was the goal of Prometheus Black, who wanted to prove that people could measure up to Professor Sumdac's robots. Unfortunately, his investors bailed out after a PR stunt turned into a disaster. One rage-induced FreakLabAccident later, he's a supervillain with a grudge against both the Autobots and the Sumdac family.
* ''The New Batman Adventures'' episode ''[[http://dcanimated.wikia.com/wiki/Critters Critters]]'' gives us augmented farm critters and pests, including giant bugs ''preprogrammed'' to 'die' after a particular length of time. Originally microbiologist Farmer Brown was only out to augment cattle and other farm animals to provide more and better food; a PR event gone awry resulted in a court order[[note]]the judge doesn't seem particularly sympathetic to Farmer Brown[[/note]] preventing him from experimenting in Gotham. [[spoiler: So Brown & daughter move to extortion by threat of bio-augmented monster animals.]]
* ''WesternAnimation/BatmanBeyond'': Genetic splicing and other kinds of augmentation were a running theme on the show.
** An episode of deals with Terry fighting a group of teenagers who were spliced with animal DNA to take on certain animal traits. Other splicers are seen throughout the series.
** A crossover episode with ''WesternAnimation/StaticShock'' also featured the "Splicers," however they seemed to be only using lizard DNA in that episode.
** The Kobra cult tried to use dinosaur DNA to create [[ReptilesAreAbhorrent a new race of reptile-people]] and take over the Earth.
** An Ace the Bat-hound centered episode involved a dogfighting ring full of biologically-altered dog-monsters.
* In ''WesternAnimation/{{Spider-Man The Animated Series}},'' Kingpin turned to this for his living weapons after a few too many failures by Smythe's robots. They were made by Herbert Landon, who was introduced accidentally turning himself into an electricity-eating, city-wrecking {{Kaiju}}. (Mostly got better, but spent rest of series looking like Two-Face.) When Smythe turned against Kingpin, Landon captured him and had him upgraded into his Ultimate Slayer form.
* Parodied in a scene from the episode "Abducted" of ''WesternAnimation/InvaderZim'', the aliens believed by duct taping a gopher to Zim's head they were fusing him and possibly making him more powerful.
[[/folder]]

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