[-[[caption-width-right:350:Illustration of common Achilles heels. By [[http://strawdogdesign.com/blog/wp-content/uploads/2009/11/weakpoints.jpg Olly Moss.]] [[labelnote:Examples included]]WoodenStake; DecapitationRequired; GoForTheEye; GroinAttack; ElementalRockPaperScissors; HolyBurnsEvil; SilverBullet; BoomHeadshot; AttackItsWeakPoint[[/labelnote]]]]-]

->''"Hey, Achilles! Nice work with the HEEL!"''
-->-- '''Bill Cipher''', ''WesternAnimation/GravityFalls''

Any seemingly {{Nigh Invulnerab|ility}}le character (or KungFuProofMook) will inevitably have some key weakness that can and will be [[FlawExploitation exploited.]] This is especially likely if the main character is a SuperHero; otherwise they could walk over criminals and other villains and flatten any chance of conflict or personal peril. Aliens and monsters that are ImmuneToBullets will usually have a fairly {{mundane|Solution}} Achilles Heel that only surfaces/is discovered when things look the bleakest.

Other versions and variations of the Achilles Heel include:
* AttackItsWeakPoint: Like Achilles himself, a specific body part is particularly vulnerable to direct damage.
* DecapitationRequired: The only way to kill them permanently is by removing the head.
* DepletedPhlebotinumShells: Weaponizing the substance that the creature is weak against.
* DramaPreservingHandicap: A method to give some sort of weakness to a character who normally doesn't have one.
* ElementalRockPaperScissors: Where one element is strong towards another and weak towards yet another.
* FantasticFragility: An in-built weakness to boost power.
* FatalFlaw: A psychological weakness, not a physical vulnerability.
* ImmunityDisability: Being immune to something comes with its own drawbacks that might be exploited.
* KeystoneArmy: Army whose weakness renders it defeated.
* KryptoniteFactor: A superhero weakness to something that has little or no effect on other characters.
* LogicalWeakness: The weakness is a logical consequence of whatever makes the character powerful.
* ManOfKryptonite: A living, walking KryptoniteFactor, which makes for a tricky enemy.
* SanityHasAdvantages: Being insane is an exploitable weakness.
* SelfDestructMechanism: [[TurnedAgainstTheirMasters Just in case....]]
* SoulJar: An object that provides great power or {{immortality|Inducer}} to its creator, but the person's essence becomes tied to it so strongly that its destruction will doom them.
* StraightForTheCommander: Enemy's commander is the weakness, and thus exploiting it. It's not that easy: [[AuthorityEqualsAsskicking the commander is usually stronger]] than a {{Mook|s}}.
* SupernaturalRepellent: Weaknesses that ward off supernatural creatures.
* TailorMadePrison: A prison designed to contain a specific character, often accounting for their weakness.
* VerbalWeakness: A usually harmless word or phrase that just so happens to hurt a particular character.
* VillainBeatingArtifact: The villain is invincible to everything ''but'' this artifact.
* WeaksauceWeakness: Weakness to something common and mundane.
* WeaponOfXSlaying: A weapon specifically designed to harm certain things, better than a normal weapon would.
* WhyDidItHaveToBeSnakes: A character-specific phobia.



[[folder:Anime & Manga]]
* ''Anime/PuellaMagiMadokaMagicaTheMovieRebellion'' reveals a key weakness in Homura's [[GameBreaker Time Control]] magic: there's a delay from its activation to when time actually stops. Sayaka hears the gears starting to whir and is fast enough to jam the mechanism with her sword. Also, if you're in contact with her, as Mami was via ribbon during their fight, you're unaffected.
* [[PlayingWithATrope Played with]] for the homunculi in ''Manga/FullmetalAlchemist''. Their immortality is fueled by the [[GreenRocks Philosopher's Stones]] in their bodies; Mustang tore Lust's out of her body attempting a one-shot kill, only for her to form a new body from the Stone. Turns out their only weakness is being killed a few dozen times (or the destruction of the Stone itself), with the exact number of "kills" required being dependent on [[spoiler:the number of human souls remaining in the Stone]].
** Pride has one in the form of pure darkness: since he uses shadow-manipulation powers, he's powerless in total darkness because you need light to cast a shadow.
** Alphonse is bound to his armor by his blood seal, and should that be destroyed, he's a goner.
** Wrath's Ultimate Eye turns him into the equivalent of a PerfectPlayAI: he can predict his opponents' moves with perfect accuracy and therefore wins almost every fight he's in effortlessly. [[spoiler:Even an Ultimate Eye cannot dodge something it cannot see coming.]]
** Played straight for the homunculi in [[Anime/FullmetalAlchemist the first anime]], where they are immortal, but can be killed if one gets anywhere near the remains of the human body they were created from. Wrath averts this because his remains were used as the raw materials in the attempt to resurrect him.
* The Zentraedi and [[Anime/Macross7 Protodeviln]] of ''Anime/{{Macross}}'' are both weakened by music - the Zentraedi because they haven't been exposed to "culture" for so long, and the Protodeviln because Basara possesses the Anima Spiritua.
* ''Anime/MazingerZ'': The titular HumongousMecha has several weaknesses:
** Mazinger can't move without its pilot. So the bad guys constantly attack Kouji when he is out of Mazinger.
** Mazinger's main body must be combined with the Hover Pilder to work. Kouji's enemies often try to prevent him from attaching the Pilder to Mazinger's head.
** Mazinger's underwater mobility is crap, even after getting upgraded to fight underwater. Of course, this is exploited frequently.
* Any character in ''Manga/GetBackers'' have fantastical abilities but with very heavy handicaps, more often than not forcing the characters to pull near-fatal trump card moves. The best example is one character of the main duo, Mido Ban, who can [[LotusEaterMachine subject people to dreams]] with his Jagan (Evil Eye) for exactly one minute in reality, but indefinitely in the dream itself, making it an ultimate twink move. The catch? He can only use it once on a person and three times total a day. Needless to say, a lot of antagonists find ways to avoid this or force him to use his Jagan needlessly until he's helpless.
* ''Manga/DeathNote'''s Shinigami, being [[TheGrimReaper grim reapers]], are immortal with two notable exceptions. First, a Shinigami's lifespan is extended by writing names in a Death Note: if a Shinigami forgets to write names, they will run out of time and die. Second is the fact that a Shinigami who intentionally uses their Death Note to protect a human - extending someone's lifespan rather than cutting it short - will die instantly. There are also a number of rules they have to follow while in the human world if they don't want to get on the bad side of the Shinigami King. On a personal level, Ryuk is addicted to apples, and goes through [[LostFoodGrievance some awkward withdrawal syndromes if he goes for too long without eating any]]. That said, Ryuk's withdrawal can't kill him, nor can starvation, as he doesn't really need to eat.
* ''Anime/ScienceNinjaTeamGatchaman'':
** The team's main vehicle, The God Phoenix, has a rather poorly thought out weakness in that all the team's sub-vehicles have to be docked for the God Phoenix's weapons systems to work. While that kind of weakness would make sense to create the plane's Fiery Phoenix effect since it's an exotic weapon system, to have it affect the regular weapons seems too much. Even worse, Galactor learns about this weakness and the visual clues for it and wastes no time to take advantage of it.
** Another Achilles Heel turned out to be their uniforms. Each piece of their clothes - shirt, pants, and shoes - turn into their uniforms. Lose any part of it and you can't transform, as Jun finds out.
* Although ImmuneToBullets, the cyborg assassins of ''Manga/GunslingerGirl'' are as vulnerable as any little girl when they are not focused. Furthermore, shooting them in the [[spoiler:eyes]] should be enough to kill them.
* Many times on ''Manga/SaintSeiya'', more than one character suffers from this. Shiryu's main means of attacking leaves his heart wide open to attacks for a fraction of a second, something a few people notice over the course of the story. Krishna likewise was only defeated when Shiryu struck his hidden "Star Points", and the Pope of Sanctuary's astral projection attacks left his body wide open to attack.
** The Pope's one is not as bad as the others, as he's smart enough to do it on targets that are far away from him and without the psychic powers you'd need to counterattack while staying in a well-guarded location. [[DidntSeeThatComing Then Shun revealed his chain would attack without missing if he had even a vague idea of who he had to attack,]] [[HoistByHisOwnPetard and the Astral Projection allowed the chain to hit him.]] Then the Pope refrained from attempting it again in case Seiya, Shiryu or Hyouga pulled something like that.
* The BigBad of ''Anime/DigimonAdventure02'''s only weakness was [[GoodHurtsEvil the Power of Dreams.]]
* ''Manga/{{Inuyasha}}'',
** A human artist gains the power to make his [[ArtInitiatesLife art come to life]], and starts creating some of the most horrible creatures imaginable as an army to obliterate his enemies. However, once Inuyasha destroys the artist's inkwell -- which turns out to be a ''magic'' inkwell -- he's down and out.
** Inuyasha himself: On the night of a new moon, he becomes fully human and loses all of his demon powers.
* Subverted in ''Legend of Lemnear''. The Big Bad transforms himself into a 50 foot demon cyclops, and the male hero: The warrior of Bronze declares [[spoiler:"You may be tough, but I know your weak spot! Your demon eye!" Then through a crazy set of acrobatics, lands on the demons face to plunge a sword into its eye. Only to have his sword shatter on contact]].
* ''Anime/DragonBall''
** Goku survives a bullet and an axe to the head (relatively) unharmed, but if you grab his tail, he'll pass out. Eventually he trains himself to not be unaffected by it. It even works when he's transformed into a giant ape. He also has a tendency of losing strength if he feels hungry, which results in his defeat in his first battle with Yamcha as well as his fight with Jackie Chun. Both weaknesses went away by the time he grew up, the former because he had his tail cut off, and the latter presumably because he got better at managing his metabolism.
** Goku and Piccolo themselves exploit this weakness in the battle with Raditz. After that attempt failed, Goku didn't bother going for the weakness again, because he remembered that Saiyans could also manually detach the tail from the body. Attempted against Nappa and Vegeta, although Piccolo finds out rather brutally that the Elites aren't stupid enough to not train that weakness.
** Goku also doesn't have a good history as far as Paralysis-inducing techniques (more specifically, the telekinetic kind) are concerned.
*** In the original ''Dragon Ball'', Goku manages to hold an edge over [[WakeUpCallBoss General Blue]], until the latter used his special power to freeze Goku's body. It's worth noting Blue nearly killed Goku no less than ''three'' times this way.
*** When fighting Tien during the 22nd World Martial Arts Tournament Chiaotzu manages to paralyze Goku several times, allowing Tien to score free hits on him.
*** During his battle against Frieza on Namek, Frieza successfully imprisons Goku in a ball of energy and Goku is helpless to stop it until Frieza intentionally makes the ball explode. This one, however, could simply be chalked up to the fact Frieza was way out of Goku's league at the time.
*** In ''Anime/DragonBallSuper'' Chiaotzu successfully restrains Goku for a few seconds using his power. Granted, Goku was only in his base form, relaxed, and Chiaotzu took him by surprise, but the fact that Chiaotzu can affected Goku for ''any'' length of time at all despite the massive, ''massive'' gap in power makes it clear it's still a soft spot for Goku.
** Though debatably non-canon, the fourth DBZ movie revealed that Namekians were sensitive to a certain sound frequency. In this case, it's the sound of ''whistling''. Piccolo flips out when Gohan whistles, but when BigBad [[Anime/DragonBallZLordSlug Lord Slug]] has everyone on the ropes, he instructs Gohan to start whistling to stop Slug. Piccolo himself avoids the weakness by way of ripping off his own ears.
* Makoto Shishio from ''Manga/RurouniKenshin'' is a ''very'' powerful swordsman, but can't fight for more than 15 minutes straight. If he does, [[KarmicDeath he will overheat to death]]. And by overheat, we mean ''burst into flames.''
* ''Manga/MahouSenseiNegima''
** Nagi Springfield is described as invincible with no weaknesses. Except for the fact that he's an {{idiot|Hero}} who needs a cheatsheet to remember spells. He also has trouble pronouncing Latin.
** Nagi's comrade Eishun is a more serious character who for his strong focus on his training means a lack of human contact, and therefore a difficulty with women. This seems a common trait in Shinmeiryuu swordsman if Setsuna is any indication. [[StalkerWithACrush Tsukuyomi]] takes this weakness [[PsychoLesbian too far in the other direction]].
* ''Manga/OnePiece''
** All Devil Fruit users have the common fatal weakness of becoming completely immobile and useless in deep water. Other fruits have more specific weaknesses; for example, Luffy's Gum Gum fruit makes him immune to blunt force, and can only be damaged by being slashed or pierced. On the other side of the coin, Buggy the Clown's fruit makes him immune to being cut, so his weakness is blunt force.
** The Logia Fruits, easily the most powerful of all the Devil Fruits, all seem to have a single weakness that negates their great power or their [[NighInvulnerability perfect defense]]. For example; Sir Crocodile, eater of the Sand Sand fruit, becomes solid when wet. [[AGodAmI God Enel]], eater of the Rumble Rumble fruit, which gives him lighting powers strong enough to destroy the entirety of Skypeia, is made completely helpless when pitted against Luffy, who is made of rubber and doesn't conduct electricity (until he finds ways to attack Luffy indirectly). Logia Fruit users can also be somewhat physically harmed when up against someone with a powerful Haki, though if a Logia user has Haki of his own he can counter that attempt to bypass his intangibility (as seen when [[spoiler:Whitebeard]] uses a Haki-imbued attack against [[spoiler:Admiral Aokiji]]). Logia users can also be hurt by someone whose Logia is more powerful than theirs in a similar area, such as Sakazuki's magma being hotter than Ace's fire.
** Franky is a powerful cyborg with superhuman defenses. Problem is, he did all of his enhancements himself, meaning that since he couldn't reach behind him to do anything in back, he's vulnerable to attacks from behind. Some of his moves therefore involve fighting with his back on the ground so that his weak point is harder to reach.
*** His genitals, especially his [[GroinAttack balls]], are his weakpoint as well.
** A few Fruit users have additional weaknesses that keep them from being completely invincible. Bartolomeo has an upper limit to both the number of barriers he can create at once and the total area he can cover with them, and his barriers [[MakeMeWannaShout cannot stop sound]]. Trafalgar Law's Fruit powers drain his stamina. Blackbeard's Logia powers draw in everything around him, so he can't dodge attacks. Some of Robin's techniques, such as making wings, are unusually tiring, and her generated limbs are considered part of her and thus make her vulnerable to any TouchOfDeath sort of power. [[spoiler:Big Mom's soul-infused constructs (known as Homies) are significantly more vulnerable to damage than she is, especially soul-targeting damage, and are also fairly disloyal and can be turned against her; either way, removing them from the equation can significantly neutering her damage output. On top of that, her soul-ripping abilities will simply not work on anyone that isn't afraid of her]].
* The Yato of ''Manga/{{Gintama}}'' have immense physical strength, but are sensitive to the sun and carry around umbrellas (which double as guns, shields (bullet-proof?), and are very durable, used something like swords) to protect themselves during the day. On one occasion a character died from being exposed to the sun only briefly, after years of being underground.
* ''Manga/{{Bleach}}''
** [[EmpathicWeapon Zanpaku-tou]] all have some kind of a weak point. [[TheMedic Hanatarou's]] can take the wounds it's healed and turn into an attack powerful enough to kill a Gillian, but afterwards it's a useless three-inch-long scalpel. Consider most enemies in Bleach have a horrible attack radius far, far greater than three inches, this makes him useless in combat. [[MightyGlacier Komamura's]] bankai can take down most enemies with just one hit, but any damage inflicted upon it also appears on Komamura, so if the enemy survived that hit and was able to retaliate... ouch. [[spoiler:Even [[MasterOfIllusion Aizen's]] got one - if you touch his sword before he starts the illusion, you can see through them. Also, while his illusions effect all 5 senses, you have to ''see'' him release his shikai once before you can be caught in them. Thus, the blind are immune.]]
** Ukitake contracted a lung disease when he was three years old. It was fatal, but his parents tracked down a mysterious holy being to beg for its intervention. It agreed to keep Ukitake alive on the condition that Ukitake repay that debt at a later date. Like Aizen and Ichigo, Ukitake has phenomenal reiatsu even by the standards of captains, but unlike those two, he cannot freely use it; it's tied up just keeping him alive. Despite this, he has made it to captain rank and is one of the longest-serving of all captains. However, his disease can debilitate him at unexpected moments, including in the middle of battle, making him unreliable on the battlefield - a fact that cost the life of his previous lieutenant, Kaien.
** Unlike all other beings (including humans), Quincies have no resistance to Hollows. While Shinigami and Humans can undergo Hollowfication, Hollowfication instead kills Quincies and destroys their souls. At best, a Hollow attack can have a permanent impact on the power level of a Quincy and his future descendents. Quincies therefore hunt Hollows as a matter of survival. Urahara uses this weakness against the Quincies who stole captain Bankais to restore the Bankais to their rightful owners. Even a tiny amount of Hollow energy can poison a Quincy's soul.
* In ''Anime/{{Voltron}}'', it turns out the right knee where Black Lion and Blue Lion connect is the titular mecha's weak point. The enemy constantly bombards it when they find out about it before they're able to pull away and finish the fight before they lose the leg. However, in the end, they fix THAT weak point and put in ''another weak point''! What the hell?!
* Many villains in ''Manga/{{Yaiba}}'' has this. For example, Bat-Man's weakness to sunlight, the Moon Bunnies' ears and Silver's [[GoForTheEye eye]].
* In ''[[Manga/PokemonAdventures Pokémon Special]]'', Yellow's Virdian-blessed powers include [[HealingHands healing]], {{telepathy}}, [[MindOverMatter minor telekinesis]], and SuperEmpowering. All this sounds like it would make her an invincible Pokemon trainer, but while her powers ''do'' make up for her sub-par battling skills, using them too much runs the risk of her being forced into a deep sleep that cannot be externally disrupted. At one point she gets taunted into using her powers vainly as to get tired out faster.
* The Gundam Double Zeta, the title mecha of ''Anime/MobileSuitGundamZZ'', is a powerhouse Mobile Suit armed with one of the strongest beam cannons made by that point. However, said beam cannon was such an energy hog that it would easily run itself out of power if continuously used.
** Power consumption is a big problem in the ''Anime/MobileSuitGundamSEED'' universe thanks to the N-Jammers preventing nuclear energy from being used. Many suits along the way have attempted to devise ways to extend Mobile Suit usage time, such as better versions of the Phase Shift armor and beam weapons that draw from external batteries. The Freedom and Justice are {{Game Breaker}}s because they have N-Jammer Cancellers that allow them to use nuclear reactors, giving them effectively unlimited operation time. Likewise for Providence, the BigBad's mobile suit. In ''[[Anime/MobileSuitGundamSEEDDestiny Gundam SEED Destiny]]'', N-Jammer Cancellers have been banned by treaty (since they also make it possible for nuclear warheads to be used), so yet another attempt to extend battery life is introduced: a technology that remotely beams energy from the mothership to the mobile suit for a quick recharge without needing to return to the hanger. And inevitably, the treaty banning nuclear power gets violated by all sides in the end.
*** In ''Manga/MobileSuitGundamSEEDAstray'', the Gerbera Straight katana was Lowe's answer to the power question - he couldn't risk using a beam saber and using a GINN's Heavy Sword used just as much power. His encounter with the blacksmith Un No leads Lowe to create the sword.
** This is also the problem concerning the GN Drive Tau in ''Anime/MobileSuitGundam00''. As the GN Drive Tau is a mass produced, but incomplete, version of the Celestial Being's normal GN Drives, it's missing a critical component to allow constant energy creation, thus it only has a limited amount when it's powered up and when it runs out, the suit's dead in the water. When a way is found to replicate the standard GN Drives' [[SuperMode Trans-Am mode]], it allows for a considerable boost in output but also exacerbates the existing weakness of the GN Drive Tau, usually burning out the Drive in the process.
* In ''Anime/GreatMazinger'', the title unit had a blind spot caused by its Scramble Dash flight pack, allowing enemies to sneak up and capture it. It was later fixed.
** It was also used for Anime/{{Mazinkaiser}} in ''VideoGame/SuperRobotWarsAlpha Gaiden'', with Mazinkaiser's Kaiser Scrander creating a blind spot. The Scrander was removed in ''Super Robot Wars Alpha 2'' to fix this.
* Many {{magical girl}}s tend to have their TransformationTrinket be their Achilles Heel due to the fact that they need it to transform and, thus, be useful. Many bad guys don't seem to actively go for these items in battle, but a few times they lead to a MidSeasonUpgrade. ''Manga/SailorMoon'' is a good example as Usagi had one brooch destroyed and a second damaged and needed those upgrades to get her powered up again, as well as temporarily losing access to them at times.
* ''Manga/AttackOnTitan'' has the Titan's vulnerable points as the base of their necks. Harm a Titan anywhere else and they'll just [[HealingFactor regenerate within minutes]], but slice the base of the neck and they die instantly. Why this is the case was a mystery for a long time, but eventually it was revealed: [[spoiler:all Titans are made from humans, and the remains of the human reside at the base of the neck. Kill the human, and the Titan dies with it. Only the Titan Shifters have the ability to revert to a human form]].
* In ''LightNovel/{{Campione}}'' the titular warriors possess magic resistance that renders them immune to most magic attacks, but if the magic enters via their mouth it bypasses the resistance as seen with Athena's KissOfDeath.
* Averted in ''Webcomic/OnePunchMan'', where Saitama despite being a traditional costumed superhero with power of NighInvulnerability inspired by the likes of Superman, never gets a real weakness and is pretty much invincible - series derives tension instead from readers being worried about characters other than Saitama who are actually vulnerable and can get hurt or die, and care about Saitama because he is unfairly treated by the ranking system in the Hero Association and public opinion rather because he's ever in any actual physical danger.

[[folder:Comic Books]]
* Perhaps the most well-known Achilles Heel is Franchise/{{Superman}}'s weakness to {{kryptonite|Factor}}. He's also perfectly susceptible to magical and ([[DependingOnTheWriter sometimes]]) telepathic attacks. It's also generally accepted that Superman would lose all of his powers while exposed to red solar radiation, since the yellow sun is the source of his power though writers waffle about whether red sunlight instantly depowers him or if he gets gradually weaker as he uses up his stores of yellow solar energy. On top of that, chi-based attacks are an opposite force to aliens and Superman's solar based powers, besides having the opposite effect on Superman than the sun, it could kill him with ease. "Chi" is life energy and the basis of magic in the DC Universe.
* The unstoppable Juggernaut from ''Comicbook/XMen'' is highly susceptible to a mental attack. His costume includes a magic helmet that blocks telepathy, meaning that the bulk of most any fight against him is a desperate struggle to remove the helmet and then a telepath effortlessly dispatching him once that's accomplished.
* ComicBook/MartianManhunter (and indeed his species) was, then wasn't, deathly afraid of fire, which did, then didn't, and now does again melt him into a puddle.
* The Comicbook/UltimateMarvel version of ComicBook/IronMan can't touch anything with his bare skin, even dust, without causing himself excruciating pain--hence the suit. He wore a special body paint that numbed him to a normal level. It also gave him a normal color since the events of his birth made him blue in addition to neural tissue extending throughout his body, the reason for his pain.
* Ultimate Professor X has one weakness... [[MemeticMutation Stairs.]]
* Traditionally, Franchise/{{Green Lantern}}s have had trouble with the color yellow--except the first of them, whose power came from a different source, and was instead vulnerable to wood. Parodied by the parallel-universe "Green Guardsman" in an episode of the ''WesternAnimation/JusticeLeague'' TV series, whose ring was powerless against aluminum.
* The alien symbiotes from the Franchise/MarvelUniverse, that created such creatures as black-suit Franchise/SpiderMan, ComicBook/{{Venom}}, Comicbook/{{Carnage}}, and Toxin, are vulnerable to "sonics"--essentially, ''extremely'' loud or high-frequency noises. Extreme heat is also a notably unpleasant weakness of theirs. There's one time when Venom has been defeated by a lit ''zippo''.\\
Conversely, Venom is Spider-Man's Achilles Heel. Since the Venom symbiote spent a good bit of time bonded to Spidey as his black costume, not only does it know all about the SpiderSense (something that routinely saves Spidey's life by giving him a heads-up on an incoming sneak attack), it's also ''immune to detection by it'', an immunity that extends to any host the symbiote is bonded to.
* {{Inverted|Trope}} with the supervillain Doomsday. If you kill him, he comes back, ''[[ItOnlyWorksOnce immune to what killed him last time]]'' (so, if you tossed him into space, he'd come back able to survive sudden changes in pressure; if you did it again, he wouldn't need to breathe the next time; and if you did it a third time, he might--[[ConvectionSchmonvection eventually]]--[[SpaceIsCold freeze]], or burn up, and come back immune to that).
* The brilliant, amoral ComicBook/{{Thanos}} from the Franchise/MarvelUniverse has a particularly strange weakness: ''self-defeatism''. As ComicBook/AdamWarlock points out in a [[BreakThemByTalking Breaking Speech]] in ''ComicBook/TheInfinityGauntlet'' [[CrisisCrossover crossover]], he subconsciously knows he doesn't deserve victory, and thus arranges his defeat without realizing it. The Vision {{lampshade|Hanging}}d it in a dialogue with She-Hulk, explaining that Thanos himself helped the Avengers to defeat him in previous battles.
* ''ComicBook/RisingStars'' features a character completely immune to physical damage. However, he still needs to breathe, and is killed by someone sneaking up behind him and throwing a plastic bag over his head. More generally, in the third story arc, [[spoiler:it is discovered that the resistance to damage that, by this point, all specials have, does not guard against radiation. Thus, a special who has spent the last 10 years stealing and hiding nuclear weapons gets radiation sickness, and any special can be temporarily weakened by an electromagnetic pulse]].
* The Gladiator, one of Marvel's many Franchise/{{Superman}} expys, is exactly as powerful as he thinks he is, so he can be defeated by denting his confidence. The typical method is for a character to use trickery to make Gladiator think they did a NoSell, then clobber him when his disbelief saps his strength.
* ComicBook/NormanOsborn, the current BigBad of the Franchise/MarvelUniverse, has one rather serious Achilles Heel: he's a nutcase. As Osborn he's a twisted and brilliant MagnificentBastard -- and a sociopath. As the Goblin he's so batshit crazy he makes his Osborn side look well adjusted. As a result, it doesn't take much effort to get a VillainousBreakdown out of him. At one point [[spoiler:due to some "nudging" by imprisoned psychics]], just being ''reminded'' of Franchise/SpiderMan led to Osborn pacing around in his office naked and ranting. And this is ''still'' saner than his Goblin persona.
* General Zod's associate Ursa has all the regular Kryptonian powers and weaknesses, but her eyes can't stand bright light. Knocking off her protective goggles will briefly stun her as she clutches her eyes in pain. The Eradicator (or at least when he reappeared after Superman's death) was like that, too--he couldn't take Superman's body and ended up forging a new one with the room around him. It wasn't perfect and he couldn't take in light properly, hence his shades. It's because of this that his battle with Steel turned in Steel's favor--he knocked off his shades fighting back.
* Originally Comicbook/{{Spawn}} had his necroplasm suit which allows him to do anything, but with a countdown of energy which, when it hits 0, drags him to hell (though once they stopped displaying the number the energy was at, this became more of an InformedFlaw). He's also vulnerable to heavenly weapons in general.
* Comicbook/ManThing was {{Nigh Invulnerab|ility}}le so long as he remained moist.
* In ''Comicbook/NewAvengers'', the Ivory Kings (aka the Beyonders) are incredibly powerful god-like beings who are able to curbstomp just about anything -- even other cosmic entities. Doctor Doom eventually discovers a key weakness: [[spoiler:the Beyonders can't TimeTravel. He tries to exploit this by going back in time to kill them at the point of their creation]].
* Within ''X-Men'' stories, it's established that Comicbook/{{Wolverine}}, Comicbook/{{Sabretooth}}, and pretty much anyone related to them who has a HealingFactor, are ''really'' hard to kill, due to their healing abilities. The one weakness they had was that beheading them would generally kill them (note that this doesn't work on Wolverine, since his skeleton is indestructible[[note]]In one story, a ''freight train'' wasn't able to decapitate him, and he ''wanted'' to die in that story[[/note]]). However, Rick Remender later established a rule to tone things down: The brain requires oxygen, and depriving it of oxygen for long enough will kill these people. That means that ''all'' of the Howletts and Creeds can die from something as simple as drowning. So suffocation is now an easier method of offing these guys.

[[folder:Fan Works]]
* In ''FanFic/AeonEntelechyEvangelion'' due to mobility reasons the joints in the armor (normal or subdermal) are less protected, and therefore exploited.
* In ''Fanfic/GodsAngelsAndKings'', Franchise/{{Godzilla}} retains his canon (one of them, anyway) weakness in the form of a large nerve cluster in his hip, which [[spoiler:Zeruel]] uses against him.
* ''Fanfic/LastChildOfKrypton'':
** Since Shinji has [[Franchise/{{Superman}} Kryptonian]] DNA, he is weak to Kryptonite.
** While Shinji fights Sachiel, he hears Rei saying that its weak point is the red core. Right away he punches the red orb until he cracks it.
* ''Fanfic/SOE2LoneHeirOfKrypton'': Being [[Franchise/{{Superman}} half-Kryptonian]], Asuka is weak to Kryptonite and she can't recharge her powers under light of a red sun.
* In ''FanFic/WinterWar'', [[spoiler:Yumichika's]] shikai power is given the weakness that if he tries to use it against someone with a sufficiently great reiatsu- say, a high-ranking Espada- rather than killing them, he is overwhelmed with their power and effectively self-BrainwashedAndCrazy.
* John in ''Fanfic/WithStringsAttached'' has to eat all the time; if he doesn't, he fades pretty fast. He's also vulnerable to shrill sounds and was completely put out of action when the Hunter's {{BFS}} started screaming.
* In ''Fanfic/TheKeysStandAlone'', it turns out that despite his overwhelming psionic power, Ringo is unusually susceptible to psionic attacks.
* In the ''Fanfic/BloodBondBloodOmenSeries'', [[spoiler:the Unshaper]] would have been completely invulnerable if it hadn't insisted on [[spoiler:using avatars]] to give destroying the Earth that personal touch.
* The trope's name is outright mentioned by Hobbes in ''Fanfic/CalvinAndHobbesTheSeries'' when fighting [[LiteralSplitPersonality Socrates' dark side]] - he's not as in touch with his feline roots as Hobbes is, and ends up taken out by a single, well-timed pounce.
* ''Fanfic/WithThisRing'': Initially, Orange Lantern (OL) has absolutely no ability to resist magic, meaning spells that others would shrug off were crippling to him. Chaos magic was even worse, as it could ignore his shields. Paragon!OL rectified this with a high-grade defensive magical amulet from Atlantis, but that only protects him from direct magical attacks, leaving magic-users one of his worst match-ups. [[spoiler:He grows out of it thanks to the Ophidian giving him a soul and lending her assistance with her resistance, though some skilled magicians can get around it.]] Grayven doesn't have this weakness due to being a New God.
** OL has a huge weakness to telepathic attacks. In a fight with Miss Martian she easily takes control of him. Renegade!OL rectifies this by getting [[TrainingFromHell training from Manchester Black]]. But psychics are terrible opponents.
*** [[spoiler:As Psimon learns the hard way OL is extremely strong against mindscape attacks because anyone invading his mind on that level also gets to fight Ophidian.]]
** He also employs clever tactics, advanced constructs, and sophisticated attacks as standard, but as a result he is easily flustered by direct, intense pressure that doesn't give him time to think or plan. This is in contrast to Green Lanterns, who are typically quite adept at simply reacting without thinking in combat.
* According to ''WesternAnimation/TheFairlyOddParents'' fanfiction, ''FanFic/NeverHadAFriendLikeMe'', a genie's lamp serves the function of portable prison, PowerLimiter (in the sense they've got to grant wishes of whoever has it), and PowerSource. Destroying their lamp, while supremely difficult, while they are still bound to it is also an assured way to kill them.
* ''FanFic/TransformersAnimatedCybertronianGenesis'': During the Siege of Polyhex, Starscream asks Megatron how he plans to defeat Optimus Prime. Megatron thinks of how Optimus draws strength from protecting those he loves, and then simply replies that every 'bot has a weakness. [[spoiler:His optics then shift to the oblivous [[OneTrueLove Blackarachnia]]]].
-->'''Starscream''': Ah. Hello, weakness.
* In ''Fanfic/PokemonResetBloodlines'', during the [[TournamentArc Fuchsia Tag Tournament]], [[TheRival Paul]] figures out the weaknesses on Ash and Red's battling styles: the former's Pokémon could be easily overwhelmed by a much stronger opponent, and the latter gets thrown off by unexpected factors. And he might have succeeded, had he not decided to [[spoiler: [[KickTheDog release his Raichu]] [[YouHaveFailedMe for losing one too many battles]],]] as this prompts Ash and Red, who at the time are angry at each other over [[OpposingCombatPhilosophies their conflicting views]], to leave their differences aside so Paul doesn't win the tournament.
* ''FanFic/{{Transcendence}}'': [[WrongContextMagic Arcane and fel magic]] both wind up being this to Ichigo. A clash between spiritual powers is straightforward; a stronger spiritual force will always triumph over a weaker one. Arcane and fel magics don't follow this rule, so Ichigo can't simply brute force his way past magically protected beings or tank spells the same way he can against spiritual and physical entities. Because of this, he has a much harder time dealing with magic users than he does with any other opponents.

[[folder:Films -- Animation]]
* In the Creator/{{Disney}} film ''Disney/{{Hercules}}'', Phil makes a reference to his old student Achilles and complains about "that [[AlterKocker furshlugginer]] heel". He even goes to Achilles' statue and flicks the heel, which causes the entire statue to shatter into a pile of rubble.
* The Omnidroid in ''WesternAnimation/TheIncredibles'' could only be harmed by its own weapons.
* ''Disney/AladdinTheReturnOfJafar'': Destroying Jafar's lamp kills him.
* ''Disney/LiloAndStitch'': Stitch's Achilles' Heel lies in his very design. Due to the high density of his molecular structure, he sinks in water. ''WesternAnimation/LiloAndStitchTheSeries'' revealed that Stitch can lift up to 3,000x his own weight (which is never specified), but not one ounce more.
* Beowulf in ''WesternAnimation/{{Beowulf|2007}}'' kills the dragon by stabbing the small part of its chest to where its heart should be, and he crushes it.

[[folder:Films -- Live-Action]]
* ''Franchise/StarWars'' example:
** One of the best known is the exhaust port on the Death Star, through which an invincible planet-destroying space station can [[EarthShatteringKaboom explode into an enormous fireball]] because of a couple torpedoes from a small one-man fighter spacecraft hit its reactor and caused a chain-reaction explosion. {{Justified|Trope}} due the simple fact the exhaust port was extremely small (only two meters wide) and would throw ''out'' exhaust, meaning the shot was considered impossible until Luke (who is a Force sensitive) somehow managed to do it.
*** In the old EU, it's made the clear the Emperor was ''pissed'' there was such a flaw and the designer repeatedly killed, brought back to life, and then killed again before putting him to work on a perfected design. The second Death Star attempted to avoid this, by instead having lots of much smaller exhaust ports, too small to shoot into. Luckily, the heroes still had an Achilles Heel to exploit because Death Star II was only about 70% complete when they attacked, which included holes wide enough for them to fly right up inside the main reactor and torpedo it.
*** In the new continuity, ''Film/RogueOne'' explains that [[spoiler:the flaw was deliberately added and laboriously hidden by a Rebel sympathizer, who was also the one who fed them the information they would need to exploit it.]]
** [=AT-ATs=] are massive {{Spider Tank}}s with heavy firepower and enough armour to [[NoSell not even notice when they're hit with blaster cannon fire]]. Aside for being hit by anti-starship weapons (that aren't normally used on a planet precisely because they're too powerful), there're four ways to take them down: the 'neck' with the weapons and the cockpit is relatively unarmored, and concentrated fire will severe the vehicle from its guidance system; the armour, while tough, isn't so effective against a large projectile at high speed such as a [[RammingAlwaysWorks kamikaze airspeeder]]; as they move through legs, a tow cable may be used to 'trip' them; finally, their armour can't resist lightsabers (that, to be fair, cut through pretty much everything), and Luke took one down by opening a hole and throwing a bomb inside.
* Possibly the silliest Achilles Heel in film history was in ''Film/{{Signs}}'', where the powerful aliens who had been wreaking havoc turned out to have a fatal weakness to ... [[KillItWithWater water.]] They shouldn't have [[TooDumbToLive invaded a planet two-thirds covered in water]] without protective suits. On the other hand the movie hints that the "Aliens" are actually demons and that that "Water" was actually Holy Water. Which would justify the water weakness.
* ''Film/IndependenceDay''. Not only is the alien mothership compatible with Mac OS, but despite millions of years of technological advancement, they don't have even the most rudimentary form of a firewall. It's possible in their [[HiveMind culture]] that software hacking was unheard of. The flying saucers are also weak to jets crashing into their giant death rays.
* In ''Film/TheWarOfTheWorlds'', the aliens are vulnerable to Earth bacteria and viruses. While new beings likely wouldn't be vulnerable to earth's viruses, bacteria would be able to wipe out any species without an adapted (or adequate) immune system. This is because the different ways that bacteria and viruses work. While it's stated to be the common cold in the movie, it could just be a "sinus infection" (bacterial). Any alien species moving to a different planet would be highly vulnerable to any and all new bacteria. This is a case of ScienceMarchesOn, since the movie came out three years before the cause of the common cold was discovered.
** In ''ComicBook/TheLeagueOfExtraordinaryGentlemen'' Volume 2, the virus was specially tailored by Dr Moreau. Yes ''that'' Dr Moreau.
* A blink-and-you'll-miss-it "Achilles Heel" appears in the Creator/JimCarrey movie ''Film/LiarLiar'', where, faced with the prospect of "doing The Claw to [his ex-wife]", main character Fletcher Reed says, "You've found The Claw's only weakness--[[IceQueen sub-zero]] temperatures!"
* ''Film/TheWizardOfOz'': The Wicked Witch of the West's vulnerability to water.
* Parodied in ''Film/ScaryMovie3''. The aliens are fighting the group (though just because strangling is how they say hello), when Mahalik decapitates one with a shovel and says:
-->'''Mahalik''': I found it! Without their heads, they're powerless!
* Also parodied in ''Film/HaroldAndKumarGoToWhiteCastle'', during a psychedelic dream sequence.
-->'''Officer Palumbo''': Bullets! My only weakness! How did you know?
* {{Lampshade|Hanging}}d and overdone ad nauseum in ''Film/{{Mindhunters}}''. The plot of the movie rests on a FBI profiler killer killing other FBI profilers by presenting them in situations where they will have to fall for traps he's devised, because said trap is their weakness. [[spoiler:In the end, he dies by getting shot in the head, causing LL Cool J's character to quip "I guess we found out his weakness. Bullets."]] However, the killer's true Achilles Heel is [[spoiler:time. Everything has to happen on his schedule]].
* In ''Film/AttackOfTheKillerTomatoes'', the eponymous tomatoes are defeated by playing the fictional artist Ronny Desmond's new hit song "Puberty Love," which causes them to shrink and become vulnerable to crushing.
* Similarly, in Tim Burton's ''Film/MarsAttacks'', the Martian attackers are defeated by playing Slim Whitman's "Indian Love Call," which causes their heads to explode.
* Talos the Titan in ''Film/JasonAndTheArgonauts'' has a near-literal version of this {{trope}}.
* The Djinn in ''Film/{{Wishmaster}}'' has one main weakness: he can only use his powers in the service of wishes, which annoys him quite a bit ("Do you have any idea how frustrating it is to have unlimited power, and only be able to use it when some worm asks you for something?"). Without a wish, he's virtually powerless except for his NighInvulnerability. Getting everyone to stop wishing is next to impossible, however. Particularly since what qualifies as a "wish" is pretty arbitrary. Like a woman at a party saying "You can see right through me..."
* Freddy Krueger of the ''Franchise/ANightmareOnElmStreet'' movies is an all-powerful RealityWarper... but only in dreams. In the real world, he is as vulnerable to damage as any normal person, although he's still [[MadeOfIron pretty resilient]]. The protagonists in the series [[ExploitedTrope use this to their advantage]] several times. In the original movie, [[spoiler:Freddy uses it right back at Nancy, since her return to the real world where she can defeat him [[DreamWithinADream turns out to still be a dream]]]].
* A rather clever one in ''Film/ManOfSteel'', [[spoiler:Clark was overwhelmed by his burgeoning SuperSenses and other powers and took some time to control them. He realizes in his first major confrontation that Zod and his crew were using sealed atmosphere PoweredArmor that minimized the reactions they would get from the yellow sun. By breaking those seals they were overwhelmed just as much as young Clark was. Zod later comments that it is a weakness they will adapt to and Zod later fights Superman with all those same powers]].
** The film also offers another natural weakness for Superman besides the stand-bys of [[BroughtDownToNormal red sun energy]] and [[KryptoniteFactor Kryptonite]]. Specifically the atmosphere of Krypton was a lot thinner and Clark had spent his whole life in a much thicker environment.
* ''Franchise/ChildrenOfTheCorn''
** Eli's weakpoint in ''Film/ChildrenOfTheCornIIIUrbanHarvest'' is his evil bible, and the book's weakpoint is Eli. To get rid of them, one must destroy them both at the same time.
** Josiah in ''Film/ChildrenOfTheCornIVTheGathering'' was poisoned with quicksilver before he died, and now in undeath he has an aversion to mercury.
* In ''Film/WhoFramedRogerRabbit'', a substance known only as "dip" is able to kill otherwise invulnerable toons. [[spoiler:It turns out that it is also the Achilles' heel of villain Judge Doom, who is revealed to be a toon himself.]]
* In ''Bollywood/RaOne'', both hero and villain are deliberately made {{Nigh Invulnerab|ility}}le --except for one weak point: their [[UpgradeArtifact HARTs]]. Neither can actually be killed unless the HART is simultaneously destroyed.
* In ''Film/EdgeOfTomorrow'', the aliens greatest ability (to reset time) is also their greatest weakness, as it can be passed on to its enemy.

* Creator/HGWells' famous work ''Literature/TheWarOfTheWorlds'' involves aliens who come to invade the Earth and the governments of the world are unable to stop them, until they get defeated by ordinary bacteria for which the aliens' immune system, having never been exposed to them, are extremely vulnerable.
* Leto Atreides II, the eponymous ''God Emperor of Literature/GodEmperorOfDune'', who combines his body with a sandworm to extend his life by thousands of years and gain immunity to almost every form of physical damage, also inherits the sandworms' vulnerability to water.
* In the ''Literature/{{Chrestomanci}}'' series by Creator/DianaWynneJones, the Chrestomanci are powerfully magic characters who are nearly invincible due to their powers, [[spoiler:and their nine lives]]. However, every Chrestomanci has one particular weakness.
* In Creator/DavidEddings' ''Literature/TheBelgariad'', it appears the Achilles Heel of the [[BigBad ancient and evil god Torak]] is to tell him nobody loves him. As everything he'd done through his existence was to force people to love him, this throws him into an UnstoppableRage... which causes him to drop his guard. Cue impalement.
* Although it can vary, [[OurWerewolvesAreDifferent werewolves]] are typically weak to silver; touching it causes severe burning.
* In ''Literature/TheLordOfTheRings'', Sauron is incredibly tough, but if the [[ArtifactOfDoom One Ring]] he created is thrown into Mount Doom, he will lose ''all'' of his power, so that all he becomes is a little formless evil spirit incapable of affecting anything around him forever. Tolkien goes to lengths to justifies this. The original point of the One Ring was for Sauron to gain control over the leaders of Men, Elves, and Dwarves, to whom he had (while in disguise) given the other rings of power. He ''had'' to put most of his strength into the One Ring in order for it to be powerful enough to control the others, especially the three Elven rings.
* Then there's Smaug, in ''Literature/TheHobbit''. He knew that dragons typically have a weak underbelly, but had rolled around in his hoard for so long that coins and gems had become embedded among his scales, creating a "diamond waistcoat" that made him {{Nigh Invulnerab|ility}}le. From this he took to calling himself "Smaug {{the magnificent}}" or "the golden". It was this protection that was flawed. There was just one spot in his belly that he missed but Bilbo didn't.
* Generally a SoulJar is '''the''' weakness for anyone who uses it.
* In ''Literature/{{Animorphs}}'' both the heroes and the villains have one:
** For the Animorphs, their weakness is the two-hour time limit they can spend in a morph. If they go over that time limit, they're trapped in morph forever.
** For the PuppeteerParasite Yeerks, their weakness is the need to leave their host body every three days and swim in a Yeerk Pool to absorb life-giving Kandrona rays. Without doing so, they will die.
* According to Dumbledore in the ''Literature/HarryPotter'' series, Voldemort's weakness is his inability to love.
** Lily Potter's HeroicSacrifice for the son she loves so much gives Harry a shield that is able to make a Killing Curse rebound and that same shield burns Quirrell's skin when he has been possessed by Voldemort, rendering him unable to attack Harry due to pain.
** ''Literature/HarryPotterAndTheChamberOfSecrets'': His brotherly love for Ron and, to some extent, Ginny, pushes him to go down to the Chamber of Secrets to rescue the girl, and his respect for Dumbledore gives him the things he requires to kill the Basilisk, one of whose fangs he uses to destroy Tom Riddle's Diary.
** ''Literature/HarryPotterAndTheGobletOfFire'': His parents' ghosts protect him when he has to run away from the cemetery after Voldemort's resurrection.
** ''Literature/HarryPotterAndTheOrderOfThePhoenix'': When he is possessed by Voldemort, just thinking of the recently deceased Sirius is enough to kick Voldemort out. Also, Dumbledore's love for him stops the Headmaster from killing Harry in the hopes of killing Voldemort (which wouldn't have worked due to the [[SoulJar horcruxes]]).
** ''Literature/HarryPotterAndTheDeathlyHallows'': First, Snape turned spy for Dumbledore when Voldemort targeted Lily Potter, whom he had always loved. Then, Snape protects Harry and helps him to the best of his ability due to his love for his mother (his mistreatment of him comes from his being a look-a-like of James Potter) during all the books. Later, Harry sacrifices himself so that his friends and schoolmates don't die (and thus casts upon them the same shield his mother cast upon him). Much later, Narcissa lies to Voldemort about Harry being alive because she wants to see her son Draco (which is the signal that they are fed up with how Voldemort has treated her). And, in the end, it's Harry's ability to work with all of his friends that allows them to defeat the Death Eaters. There is also his reliance on and treatment of the horcruxes. They were supposed to prevent him from dying, and they accomplished that perfectly well. The problems were that: a) He was very lax with their protection at times (giving the diary to Lucius Malfoy, for example), because he had so many, and b) He couldn't tell when they were destroyed and so left his guard down.
* One of ''Literature/TheDemonHeadmaster'' books featured a super logical computer which was defeated by all the children in the world yelling pointless anti-logic.
* In Creator/DanSimmons' ''Literature/{{Illium}}'' and ''Olympos'' the Trojan war is being deliberately recreated. Part of this involves Achilles being given a sort of quantum invulnerability that ensures he will only every be hurt by an arrow intentionally fired at his heel by Paris, which probably takes the cake for most specific and most inevitable Achilles Heel.
* Fairy folk in the ''Literature/ArtemisFowl'' series are all susceptible to animal fat. Being exposed to animal fat will suck out all of their magic.
* This becomes a plot point in the final book in the ''Literature/PercyJacksonAndTheOlympians'' series. A character who bathes in the River Styx gains the "Curse of Achilles," making him or her a one-man army. However, since humans aren't meant to be invulnerable, the Styx will burn them away if they don't focus on one point on their body to be their mortal point--a literal Achilles Heel, just not at the heel. [[spoiler:Percy]]'s Achilles spot is the small of his back; [[spoiler:Luke]]'s is his left armpit.
* The Steel Inquisitors in Literature/MistbornTheOriginalTrilogy are ''very'' dangerous customers, with [[FunctionalMagic Allomantic]] powers as well as superhuman strength and speed. [[spoiler:However, the steel spikes that pierce their body are their weakness - if you pull out both the spikes in their eyes, or the one in their upper backs]] it kills them instantly. [[spoiler:Marsh]] uses this to [[spoiler:take out all the Inquisitors in Luthadel near the end of the first book]]. Of course, when they show up again in the third book, they've learned and armored up their weak spot.
** Also, [[spoiler:all creatures created with Hemalurgy, Steel Inquisitors included, can be controlled by a Mistborn using Emotional Allomancy along with duralumin. Or by several Soothers or Rioters working in concert, or by [[BigBad Ruin]]]].
* In Creator/AaronAllston's ''Literature/GalateaIn2D'', Red comes from a painting of Achilles and has the heel.
* In ''Literature/TheDresdenFiles'' Nicodemus is made invulnerable by wearing [[PublicDomainArtifact Iscariot's Noose]], but [[spoiler:he's vulnerable to the noose itself, which naturally is conveniently already around his neck]].
** Fairies are consistently vulnerable to iron.
* In the ''Literature/SimeGen'' series Simes frequently kill Gens by sucking out their LifeEnergy, but any Gen can kill the Sime first if they know where the Sime's conveniently at hand weak spots are.
* In the last book of ''Literature/TheWheelOfTime'' [[spoiler:Padan Fain, aka Mordeth, aka Shaisam had become a borderline EldritchAbomination with a host of unnatural powers and a small army of the undead at his disposal, and was a genuine threat to the forces of both good and evil- not bad for the snivelling PunchClockVillain he started out as. However, his original human body, which was at the heart of the shifting cloud of [[FogOfDoom white killer mist]] that in many ways was ''really'' him, remained mortal. When [[BadassNormal Mat]] killed said human body, the entire horrible entity was dissipated]].
* ''Literature/LegacyOfTheDragokin'': Due to Jihadain's magic, the Kthonian Knights can survive any injury so long as their heart remains intact.
* ''Literature/AdventureHunters'': No matter how powerful the gargoyle, light will turn him to stone.
* In ''Literature/ThoseThatWake'''s sequel, hired goon Castillo has a weak knee.
* Even though it features the trope namer, ''Literature/SongOfAchilles'' does not include the literal heel as Achilles' one weakness. Metaphorically it's actually his {{Pride}}, and he dies by being shot in the heart by an arrow shot by Paris and guided by Apollo. This is actually consistent with the original version by Homer since the bit with the heel was added several centuries later.
* The werewolves in ''Literature/UncommonAnimals'' heal faster than normal people, but a blow to the head still stuns them.
* The proxy worms in the ''Literature/{{Fallocaust}}'' series can only survive in highly radiated areas. Although they can inhabit a born immortal and use their abilities to irradiate an area, it's also possible for an uninfected born immortal to absorb enough radiation in an area to kill them off.

[[folder:Live-Action TV]]
* In ''Series/{{Angel}}'', where Angelus figures out the Beast's weakness:
--> "I mean, look at this guy, hm? Pretty much the only thing that could do damage to that thick, stony hide...is himself. Or, maybe, I don't know, a piece of himself."
* ''Series/DoctorWho'' does this ''a lot''.
** In "The Moonbase", Cybermen were weak against solvents, or as the Doctor would later put it, "cleaning fluid".
** Cybermen were also given an Achilles Heel in the story "Revenge of the Cybermen": gold dust would asphyxiate them. This was not a tremendously damning weakness, since gold is neither common nor easy to form into an effective weapon. In "Revenge of the Cybermen", the Cybermen were Nigh Indestructible even on a ''planet made entirely of gold'', because the locals didn't have the technology to make an effective delivery system for the gold. As the series progressed, gold was promoted to Kryptonite status: in "Earthshock", the Doctor injures, but does not incapacitate, a Cyberman by grinding a gold badge into its chest, but by "Silver Nemesis", Cybermen can be killed by lobbing gold coins at them, or shooting gold-tipped arrows. Gold-tipped arrows are very effective against Cybermen, but, of course, totally ineffective against anything else. It is sometimes joked that had the original series gone on, it would eventually have been possible to destroy a Cyber-war-fleet just by ''saying'' "gold" at them. After the show was revived in 2005, [[AllThereInTheManual a fake website connected to the revival's second series]] hints that the Cybermen seen in "Rise of the Cybermen" and later episodes had the gold weakness worked out in the prototype stage. It was showed on a computer screen in that episode that the weakness had been worked out. Though not present in the Cybermen themselves, the older programming of the Cyber-Planner in "Nightmare in Silver" made it temporarily shut down when a golden ticket was placed against it. The latter story also revealed this weakness to be a software error, rather than a hardware one.
** In addition, the Cybermen have been vulnerable to emotions in several appearances.
** The Sontaran's 'probic vent'. "Back of the Neck!" Of course [[spoiler:bullets work perfectly well too…]]
** The Slitheen, being composed largely of calcium, can be killed with acetic acid, most commonly accessible as '''vinegar'''.
** The Daleks were originally vulnerable to turning off the static electricity. They also couldn't climb stairs due to their flat bases and gliding motion, which was made fun of outside the universe and sometimes even in it. However, ''Remembrance of the Daleks'' managed to bring a whammy subversion by showing Part One ending with an Imperial Dalek ascending a flight of stairs, ready to '''EX-TER-MIN-ATE''' the Doctor. From that point on, all Daleks could levitate.
** The Macra were helpless without their special gas (which made one wonder how they managed to force humans to start making it in the first place).
** The Ice Warriors are vulnerable to (what else?) heat.
** The deadly sea weed of ''The Fury from the Deep'' were vulnerable to Victoria screaming (luckily, she was good at it).
** Autons are also vulnerable to solvents and high-frequency noises.
** The Nestene Consciousness is susceptible to "anti-plastic" and, like its minions, high-frequency noises.
** The "Seeds of Death" are (ironically) vulnerable to water.
** The evil computer in ''The Green Death'' was vulnerable to [[LogicBomb logical dilemmas]].
** The maggots in ''The Green Death'' weren't fazed by bullets, bombs, or bug spray, but met a quick end after eating hybrid mushrooms meant to be a meat substitute.
** Mandragora energy is vulnerable to being conducted away.
** The Fendahleen are vulnerable to salt.
** The giant octopus Kroll was vulnerable to... a small stick. Okay, a ''special'' stick.
** The Mara is (are?) vulnerable to mirrors and happy thoughts.
** The Sea Devils and Silurians are helpfully vulnerable to a deadly gas which is blatantly introduced at the start of "Warriors of the Deep", then conveniently forgotten about until the climax.
** The Destroyer in "Battlefield" is vulnerable to silver.
** Fenric is vulnerable to puzzles.
** The Master leaves himself vulnerable to happy thoughts in "Last of the Time Lords". In addition, his biggest weakness throughout the series is... the Doctor, the one person he's never fully understood. (One episode of the classic series shows that his worst fear is a room full of the Doctor, laughing at him.)
* In ''Series/GameOfThrones'', being stabbed with dragonglass or Valyrian steel causes White Walkers to crystallize and shatter. After all, what's the opposite of ice? Volcanic glass and dragon-forged steel.
* In ''Series/TrueBlood'', besides the usual vampire weaknesses (sunlight and silver), since vampires are undead, they can be controlled by a necromancer, to the extent they can be forced awake during the day and made to walk into the sunlight to their demise.
* In ''Series/TheSixMillionDollarMan'' and ''Series/TheBionicWoman'', extreme cold could make the bionic heroes' parts stop working until they warmed back up.
* In ''Series/{{Heroes}}'', Claire Bennet has a Wolverine-class healing factor that can repair her body to brand new after taking the [[GoodThingYouCanHeal unrealistically extreme amount of punishment]] that always comes her way. However, if an object is stabbed into a certain spot in the back of her head, she's rendered [[NotQuiteDead "dead"]] until it's removed, and the same goes for anyone who [[PowersAsPrograms copies her powers.]] It's implied ([[spoiler:and confirmed in an alternate future episode]]) that if this part of her brain was removed or destroyed, she would die permanently.
* The Blutbad from ''Series/{{Grimm}}'' have a weak spot at the lower right part of their back. If hit there it will stun them for a few seconds.
* Sheriff Lucas Buck's vulnerability in ''Series/AmericanGothic1995'' is his ThirdEye--if stabbed there, he could be killed. What makes this a particularly JustForFun/{{egregious}} example is that not only is there no indication of this vulnerability until the next to the last episode of the show, but what could have been a very cool mythologically resonant plot point is instead wasted twice over: the person who reveals and exploits this weakness is a throwaway character we'd never met until the previous episode and [[WeaksauceWeakness the stabbing doesn't even take, since Buck is revealed alive in his grave at the end of the episode]].
* In ''Series/StarTrekDeepSpaceNine'', Founders are almost absolutely immune to physical damage, vulnerable to BIG amounts of radiation or phaser weapons... [[spoiler:and can be killed by specific virus.]] There is another downplayed weakness: Odo has to go into liquid form for 8 hours a day, much like humans need to sleep. In one episode, he was prevented from doing so, and started physically falling apart as a result. This is not a problem for the others and is only a problem for him because of his lack of experience shapeshifting.
** ''Series/StarTrekTheNextGeneration'' has Data, an incredibly strong, fast, durable, and intelligent android...with an off switch on his side. Flipping it renders him effectively dead until he's turned back on.
** The Borg are near unstoppable forces of nature that assimilate and adapt to everything they come across, but ''Series/StarTrekVoyager'' reasoned that if they can't assimilate it then they can't adapt to it, which is why they were so vulnerable to Species 8472. The Voyager crew, on the other hand, used scientific investigation and creativity, which allowed them to design a weapon to use against 8472. They are also unable to adapt to blades: Worf killed them plenty with those and they ''never'' adapted.
* Although not one related to the villain itself, the Goa'uld of ''Series/StargateSG1'' have force shields that can be bypassed by slower-moving objects. (Bullets won't work, but a thrown knife will). Later, the Replicators can only be destroyed with projectile weapons. Yes, their only weakness is ''getting shot''. [[ItMakesSenseInContext It makes sense in the show.]] Specifically, energy weapons don't work on Replicators because the machines have energy shields resistance to all forms of harmful energy. However, projectile weapons like modern-era guns do their damage through ''kinetic'' energy, which causes the Replicators' relatively fragile bodies to shatter. Even this only slows them down, as the Replicators reassemble themselves from their component parts. Later a weapon is developed that disrupts the energy field animating the blocks, finally giving the heroes and effective way to kill Replicators.
* Each MonsterOfTheWeek in the short-lived ''Series/DeadlyGames'' generally could only be stopped in two ways and were otherwise invincible. The first varies from villain to villain but is usually elaborate or silly: shoot him with an arrow [[AttackItsWeakPoint through the small target on their chest]], drop a house on her (a mobile home worked in a pinch), etc. The second is always "foil their evil plan"; they don't get do-overs. Either method makes them vaporize instantly.
* ''Series/MightyMorphinPowerRangers'':
** The Warzord Cyclopsis was one of the best things Rita ever deployed, because its computer could adapt to each Zord and Zord formation used, (configuring the shields, targeting, weapons, armor-plate angling and such). However, quickly switching formations enough would overtax this system, causing the computer to lock up due to being asked to do more tasks at once than it was capable of. This allowed the Rangers to beat its restored form, obliterating it permanently.
** Z-putties. In the first fight, the rangers stated they were invincible, until Jason discovered they explode when you hit the "Z" on their chest. Later, kids were able to destroy them launching balls at the "Z".
** Because he was the SixthRanger, the Green Ranger was plenty powerful, but because of how he returned to action, he couldn't stay in battle too long or his powers would run out. Come the second season, most of Zedd's early plots were essentially "take out Tommy."
** ''Series/PowerRangersLostGalaxy'' had the Chameliac Warrior who copied the Rangers' powers... that is, until they swapped their attack moves with their friend's moves: Pink used Blue's moves, Green used Yellow's moves... you get the idea.
** The Storm Megazord of ''Series/PowerRangersNinjaStorm'' (and it's ''Series/NinpuuSentaiHurricaneger'' counterpart, Senpuujin) had a SuperMode referred to as "Lightning Mode'/"Senpuujin Hurrier" that purged its armor and made it extremely agile - but only for sixty seconds. After that, it risks internal damage.
** In ''Series/PowerRangersMysticForce'', the otherwise invincible Megahorn's only weak spot was a small area on the back of his neck. This was carried over from Drake in ''Series/MahouSentaiMagiranger''.
* In ''Series/MythQuest'', the main characters meet two mythological characters that have this kind of flaw: Baldr and Lleu, from Norse and Welsh mythology, respectively.
* For all their power, Whitelighters and Elders in ''Series/{{Charmed}}'' can be mortally wounded by arrows tipped with Darklighter poison. Additionally, a wounded Whitelighter/Elder cannot heal themselves in this event (but another, unwounded one can).
* The immortal Adam of ''Series/{{Forever}}'' reasons that the weapons used to give him and Henry their first deaths (an ancient Roman dagger and a flintlock handgun, respectively) can also give them their FinalDeath. [[spoiler:Subverted, at least as far as Adam's theory goes: Henry resurrects even after being shot with the aforementioned flintlock. Turns out Adam was mistaken.]]
* Minbari warships in ''Series/BabylonFive'' depend on a large drive fin in their aft to move, and if it's taken out they are immobilized. This weakness is offset by Minbari warships having a ludicrous firepower and [[StealthInSpace being almost impossible to target]], meaning that among the Younger Races only another Minbari ship (whose sensors can break through the Minbari stealth) can take advantage of this weakness.
* Cecilman from ''Series/TheLibrarians2014'' episode "The Librarians and the Infernal Contract" is an all-powerful demon who will grant the wish of whoever signs his contract, in exchange for their soul. He's basically unbeatable in any kind of straight-up fight, but he does have one crippling weakness: He must grant the wish of whoever's name is on the contract, even if that wish would hurt him. Eve Baird exploits this weakness by signing the contract herself and then wishing that Cecilman [[BroughtDownToNormal was a human being.]] He becomes human, freeing both Eve and the previous signatory from the contract (as Cecilman is no longer a demon, he has no claim on Eve's soul).

[[folder:Myths & Religion]]
* Myth/ClassicalMythology:
** The [[TropeNamers name]] for this trope is the Greek hero Achilles. In Homer, he's not invulnerable (he bleeds from a minor spear wound). Classical Greek art depicts Achilles being killed by an arrow to the body. But Statius, writing in the 1st century AD (900-some years after Homer), gave him a colorful superpower. According to Statius's account, Achilles' mother, the nymph Thetis, dunked him in the River Styx to make him immortal. However, she wasn't able to dunk the foot she held him with, since as a goddess, she could not bear the touch of the Waters of Styx. Quite naturally, he was killed by a poisoned arrow to the heel, courtesy of Prince Paris of Troy. [[FridgeLogic For some reason she didn't think to dunk him, pull him out, dry him up, flip him over and dunk the dry foot]] (according to the myth, Thetis had seven children, but only Achilles survived the dunk in Styx, presumably Thetis didn't want to risk dunking Achilles a second time). An alternate version has Thetis anointing Achilles with ambrosia and burning the mortality out of him over a fire. Her husband Peleus happened to walk in on her and, well, there's a reason the two are living separately by the time Achilles grows up.
** Also from Greek myth, the Gigantes were the children of Gaia and only had their supernatural powers when they were touching the ground. Heracles defeated one of them by picking him up with one hand and beating him with the other. Other stories say the true Gigantes could only be killed by weapons of a mortal being. Hence, the gods invited Herakles (or perhaps that was the entire point about their affairs with mortal women). Some Gigantes were defeated by gods, but not killed - one is still alive, breathing fire under Etna.
** Another weak-heeled one was Talos, a giant bronze man who guarded Crete from invaders and was defeated by losing the nail in his heel that acted as a plug for the one vein in his body and promptly bled out.
* In the Persian epic ''Literature/TheShahnameh,'' the Persian prince Esfandyar bathed in a pool of invincibility, but kept his eyes closed as he submerged himself. When he picks a fight with the hero Rostam, he gets killed by an [[EyeScream arrow through his eyeballs]].
* In the [[Literature/TheBible Biblical]] Book of Judges, Samson loses his SuperStrength when Delilah [[TraumaticHaircut cuts off his long hair]]. Notice that this is hinted to ''not'' be a 100% Achilles Heel. HotBlooded as he was, Samson had broken all of the other rules God gave him to keep his SuperStrength and telling Delilah about his hair (and how he was consecrated to God) was figuratively the last straw. In a nutshell, the big three vows require Nazarites to abstain from alcohol, to not cut their hair, and to avoid corpses. Apparently Samson was known to have had wine in the past, touched (and consumed honey out of) a lion's corpse and there was that whole 'beat hundreds of Philistines to death [[ImprobableWeaponUser with the jawbone of an ass]]' bit, which doubtless left him around a number of dead bodies afterwards.
* When Baldr of Myth/NorseMythology started dreaming of his own death, his mother went around to every single thing in existence and made them swear an oath to never harm Baldr. Presto, invulnerable god, right? Not quite: she forgot to ask mistletoe, since it seemed too small and shriveled to be a threat. When the rest of the pantheon decided to make [[WhatCouldPossiblyGoWrong "Let's throw things at Baldr"]] into their favorite party game, Loki (who was [[GreenEyedMonster jealous]] of the attention accorded Baldr) tricked the blind Höðr into shooting a Mistletoe arrow at Baldr...
* In the German poem, the ''Literature/{{Nibelungenlied}}'', the hero Siegfried [[BloodBath bathes in the blood of a dragon]] after he's slain it, and becomes invincible as a result. However, a leaf had stuck to his shoulder, and thus left a spot there untouched by the blood... and yes, the similarities between him and Achilles have been noted before.
* Myth/{{Russian mythology|AndTales}} features Koschey the Deathless, an elderly evil warlock who has his death [[SoulJar stored separately from him]]. His death is a needle hidden in an egg, that's inside a duck, that's inside a hare, that's inside a chest, [[OverlyLongGag that hangs on a great oak, that grows on a distant island]]. To kill Koschey, a hero must break the egg and/or the needle.
* The Tlingit people of the Pacific Northwest have a monster with an Achilles Heel: Once there was a giant that ate people. A man decided to kill the giant, so he played dead where the giant walked every day. The giant found him, brought him home and left to get firewood. The man jumped up, threatened the giant's son with a skinning knife to make him tell where his father's heart was. It was in.... The left heel! The giant returns, and the man stabs his heel. The giant screams, "I will eat your people forever!" But the man chops him into pieces and burns him. The ashes become mosquitoes, which form into a cloud and laugh, saying "I told you: I will eat your people forever!" Then the man looks on his arm, which has a mosquito on it...
* ''The Folklore of Discworld'' mentions one British town's story of a {{Nigh Invulnerab|ility}}le dragon that had only one unarmored spot on its body, which was its anus. It was slain by a hero's well-placed (and spike-booted) kick under the tail.

* Basketball player Shaquille O'Neil (or [[FanNickname Shaq]]), one of the best players in NBA history, had an infamously poor free throw percentage. The best way to keep Shaq from steamrolling you was to intentionally foul him, forcing him to shoot free throws that he'll probably miss. This tactic became known as "Hack-a-Shaq." Interestingly, Shaq was a consistently decent-to-good free throw shooter in practice throughout his career; something about the pressure of being put on the spot in a game situation always threw him for a loop.
* Lebron James, a seemly unstoppable force, was exposed as a poor mid-range shooter during the Finals of the 2006-07 season. He's since corrected this problem, however; as the Finals during the 2012-13 season would prove. And both against the same Finals opponent, the San Antonio Spurs.
* In the world of boxing, a large number of knockout artists often have weak chins that make them just as vulnerable to getting knocked out themselves.

[[folder:Tabletop Games]]
* ''TabletopGame/{{Anathema}}'': It is literally impossible for a human to kill a shroud. They can fly as fast as a commercial jet, move through walls, become invisible, and have magic powers, but they can be killed by other shrouds and will be utterly destroyed if their will drops to 0.
* ''TabletopGame/DungeonsAndDragons'': many monsters have specific weaknesses that either do more damage than normal, or are necessary to even be able to kill them. The most famous is arguably the troll, which in most editions can't be killed with just standard weapons, but that also needs to be burned with acid or fire for it to permanently die. Unconventional tactics can also exploit certain weaknesses, or at least find other ways to kill them. Also included are demons/devils vulnerability to certain metals such as cold iron and silver
* Virtually any named enemy in ''TabletopGame/{{Deadlands}}'' will be {{Nigh Invulnerab|ility}}le, except for one weakness somehow obscurely related to [[spoiler:its past]]. The list goes on: Stone, Raven, the Bishop, [[BigScrewedUpFamily prominent Whateleys]], [[spoiler:Grimme, [[BigBad Death, War, Pestilence, Famine]] ]]... In fact, it's so common that one of the most coveted abilities of arcane characters is the rare ability to intuit these weaknesses. (That's part of why the BadassNormal[[BandOfBrothers posse]] keeps the bookworms around.)
* ''TabletopGame/{{Champions}}'' was the first ever Tabletop RPG to feature ''intentionally'' taking weaknesses (called "Disadvantages" in the rules) as a part of the character creation process. The disadvantages "Susceptibility" (which causes a character to take damage from something other characters find harmless, such as Superman's reaction to Kryptonite or a vampire's taking damage from holy water) and "Vulnerability" (which multiplies incoming damage from certain types of attacks, such as a werewolf's vulnerability to silver) were specifically created to mimic an Achilles Heel.
** ''TabletopGame/{{GURPS}}'' [[FollowTheLeader copied the Vulnerability disadvantage]] from ''TabletopGame/{{Champions}}''.
** Most {{Tabletop RPG}}s based on ComicBooks (''TabletopGame/{{Villains and Vigilantes}}'', ''TabletopGame/MutantsAndMasterminds'' etc.) have followed ''TabletopGame/{{Champions}}'' lead when it comes to weaknesses as a standard part of their character creation rules.
* ''TabletopGame/{{Shadowrun}}'' has the Allergy disadvantage, which comes in three grades, depending on the effect of contact with the substance: mildly annoying, exceptionally discomforting, and physically harmful. Shapeshifters automatically have Severe Allergies, typically to silver, vampires have Severe Allergies to sunlight and Moderate Allergies to garlic, etc. The really silly thing is that the rulebook has some recommendations for allergies, which include seawater and oil.
* Yozis in ''TabletopGame/{{Exalted}}'' can be sent through an agonisingly painful and debilitating death-and-rebirth cycle if you take out their [[DemonLordsAndArchdevils fetich soul]]. It is worth noting, however, that this is often ''much'' harder than it sounds.

[[folder:Video Games]]
* As powerful as [[Franchise/SuperMarioBros Mario & Luigi]] are (They are the ''Super'' Mario Bros after all), they seem to have one consistent weakness throughout the series: Losing their iconic [[NiceHat hats]]. In ''VideoGame/SuperMario64'', Mario's defense decreases (he takes more damage) should he happen to lose his hat. He is also unable to use {{Power Up}}s, causing a Bob-Omb to appear out of power up boxes. Taken even further in ''VideoGame/SuperMarioSunshine'', where Mario slowly dies unless he gets his hat back. It was finally taken to a logical conclusion in ''VideoGame/SuperMario3DLand'' and ''VideoGame/SuperMario3DWorld'', where the Mario Bros, [[OneHitPointWonder small forms]] are hatless. The [[ClothesMakeTheSuperman clothes really do make the Superman]] in this case.
* Just about any [[AttackItsWeakpoint glowing spot]], on any {{boss|Battle}}, in any video game. Sometimes just does extra damage if hit, but is often (in {{Platform|Game}}ers especially) the only place where the boss is not {{Nigh Invulnerab|ility}}le.
** If there is no glowing spot, [[BoomHeadshot heads]] and [[EyeScream eyes]] are also favored weak points.
* In many FirstPersonShooter games, enemies may have strong body armor, but can be killed faster by shooting them in the head (i.e. headshots).
** For example: VideoGame/HouseOfTheDead, where not only do headshots take down enemies faster, but each boss has a specific weakpoint, and cannot be damaged (or only take minimal damage) if shot anywhere else. The best one is the one with a huge gaping hole in its chest that opens to reveal its heart every time it beats (How...not easy...).
** Tried to be subverted with the final bosses, where the weak-point identifier (journal, PDA, ect) malfunctions or otherwise doesn't tell. While showing a close up of the boss in question. Showing their glowing, red weakspots. Sega seemed to give up in Overkill, as it flat out tells you instead.
** ''VideoGame/TheHouseOfTheDeadOverkill'' points these out before you face the boss in the loading screen.
* The superhero MMO ''VideoGame/CityOfHeroes'' balances all classes and power sets by giving them strengths and weakness, but only the Peacebringers and Warshades have a specific crippling weakness, Quantum Energy damage, which only [=NPCs=] with Quantum Weapons can deal. The problem was that the developers overdid it and made the weapons available to every enemy group in the game, essentially distributing kryptonite bullets, and it many cases it was powerful enough to kill the player in a single hit. As this was a major gripe about the two classes, eventually the developers responded by reducing the effects of the weapons to make it simply a danger rather than an overwhelmingly crippling threat. Furthermore, many defensive sets have Achilles Heels in the form of damage types they offer only minimum protection against. Ice Armor melts under fire damage, Fiery Aura is susceptible to cold, Dark Armor has only minor protection against energy and so on. Only two or three armors in the game offer appreciable protection against psychic attacks.
* ''Franchise/TheLegendOfZelda''. Boss monsters are often vulnerable in the eye. [[BigBad Ganon/Ganondorf]] usually has a spot on his chest or his weakness is his tail. The Master Sword is more or less kryptonite because the sacred sword has the power to repel evil.
** Many enemies and bosses have a crippling weakness that is not immediately apparent, and requires use of an uncommon technique or one of Link's many, many secondary weapons. Knowing the method can easily reduce DemonicSpiders and even final bosses from hellish trials to mere annoyances. Often the boomerang is involved: it can stun most enemies, even those with an otherwise impenetrable defense, and in some games can OneHitKill even the strongest of enemies. A common alternative is to FeedItABomb.
** In particular, there is Veran from ''VideoGame/TheLegendOfZeldaOracleGames''. Her specialty is DemonicPossession, and in such a state she is effectively invincible, because the heroes don't want to harm her host. However, hitting her with a mystery seed briefly breaks her possession spell, allowing her to be attacked directly. She tries to cover this by investigating mystery seeds early in the story (presumably to defend herself against them), though ironically this leads Link straight to the tree that produces them. Probably also doubles as a WeaksauceWeakness, though the seeds are at least somewhat rare.
* In the later editions of the ''Franchise/ResidentEvil'' series, bosses began to show certain specific weak points. For example, all of the Uroboros creatures in ''[=RE5=]'' have glowing weak points which can be shot to expose bulbous body parts that can then be targeted to kill the creature itself.
** ''VideoGame/ResidentEvil4'' gives two main ways of dealing with Krauser. Shoot him in the knee so he drops his shield, then shoot him in the head, over and over again. With indifferent aim it's easy to run out of ammo before Krauser is killed by gunshots. Or stab with the knife, normally a weak EmergencyWeapon, about 10 times.
* In ''{{Videogame/Robocraft}}'', no matter how good your robot is built, there are two main weak points : the blocs under your driver seat, and the driver seat itself. Lose either, and the bot immediately explodes.
* ''VideoGame/StarshipTitanic'': "Please do not prod my Achilles buttocks." The line is delivered by the Maître d'Bot (in a hilarious French accent) when you poke him in the butt with the stick. You have to do this because it's the only way to get to the corpse holding a fuse you need to repair the ship.
* Some ''Franchise/{{Pokemon}}'' have "abilities" that can have this effect.
** Shedinja is immune to 13 of the 18 attacking types, thanks to "Wonder Guard." However, it will always get knocked out quickly when hit by an attack of those 5 that can hit it because it has just one hit point at any level. Several forms of indirect damage will also defeat it, like switching in when the widely used Stealth Rock is up. Oddly, this leads to Shedinja being used in both the lowest and highest tiers in competitive battling. Those 5 types and Stealth Rock (especially in overused) are much more common in the middle and low tiers. However, in the lowest tier it actually has stats that don't completely suck compared to other Pokémon.
** Slaking has ridiculously high stats, so it's {{nerf}}ed by its "Truant" ability, which only lets it attack every other turn. The nastiest thing a Slaking can face is an opponent with Protect--a move that completely neutralizes any incoming attack, but is only guaranteed to work if you don't use it two turns in a row. (Detect also works, but has less PP.) Slaking can't attack two turns in a row, so an enemy with Protect can simply alternate between that and any other move, [[DeathOfAThousandCuts chipping away at Slaking]] or weakening its stats while it sits there helplessly.
** Then there are Pokemon that have double weakness against some elemental types, which means that basically any attack of that type will faint them. Rather unfortunate for those who have double weakness to [[ThatOneAttack Stealth Rock]]. This can also include, and frequently does, some of [[InfinityMinusOneSword Infinity -1 Mons]] that aren't banned in battle facilities like OlympusMons. An example would be Dragonite, Salamence, Hydreigon, Nihilego ..
* In ''VideoGame/LostSoulsMUD'', great power notoriously often comes with great vulnerability to holy damage.
* Every RPG ever with a BarrierChangeBoss. Figuring out what the new Achilles Heel is in order to even make a dent in the boss (or avoid healing it) [[PuzzleBoss is the entire point of the battle]].
* While almost any of the monsters' body parts in ''VideoGame/MonsterHunter'' can be attacked and damaged, going for their weak points is the fastest way to finish them off. Of course, weak points vary from monster to monster, although it's usually the head, stomach or limbs. This becomes a sort of GuideDangIt moment if you're unfamiliar with the monster you're fighting and unsure of where to hit them, although visual cues do exist to help players tell whether they've dealt a damaging blow, most frequently in the form of a lengthy HitStop and [[HighPressureBlood huge splashes of blood]].
* In a rare FightingGame example, [[VideoGame/PunchOut Little Mac]] in ''VideoGame/SuperSmashBros'' is PurposelyOverpowered... on the ground. If he's thrown or launched into the air even once, he becomes almost completely helpless.
** The VideoGame/{{Ice Climber}}s perform at all times as a duo. Taking out the lead Climber respawns them both as it would any other fighter; taking out the partner Climber severely cripples the lead, as their recovery power no longer works effectively (unless you count "boosts you upwards by mere millimeters" as working) and their attacks lose a lot of utility as they expect to be performed by both Climbers in tandem.
* The {{Trope Namer|s}} appears in ''VideoGame/WarriorsOrochi'', but this trope is averted. In no way you can attack Achilles on the heel, and you can beat him by just beating the crap out of him on any body parts.
* The Reactor in ''VideoGame/MightAndMagic VI'' has a very simple Achilles Heel: it only takes damage from blasters. This is, in fact, blasters greatest advantage: their damage ignores any resistances or immunities possessed by enemies, and as the final dungeon not only features the Reactor you need to destroy, but also hordes of enemies with high resistances to every other sort of damage...
* Parodied somewhat in ''[[VideoGame/GanbareGoemon Mystical Ninja Starring Goemon]]''. At one point you receive an item called the Achilles Heel which is used to defeat a minor boss in a timing minigame.
--> '''Narrator''': Ever since the Achilles' heel was thrown at Benkei... \\
'''Narrator''': Achilles' heel was meant to be the weak point of someone. \\
'''Ebisumaru''': There's something fishy about that story...
* ''VideoGame/ShadowOfTheColossus'': The whole point of the game is to kill [[{{Kaiju}} Giant Monsters]] via this method, with the creatures often having more than one, being in really hard to reach places, or requiring a lesser weakness be exploited before the real one opens up. Finding the weak point is fairly straight forward. Staying on the thing long enough to damage it while it bucks about trying to throw you off it? Less so.
* ''VideoGame/DarkSouls'':
** The Everlasting Dragons were completely invincible to any kind of attack... except for lightning. This weakness holds true throughout the series: anything draconic in nature will often have a weakness to electricity, and those who hunt dragons often wield electricity-imbued weapons.
** Anything related to the Abyss and the Dark will often be weak to Fire, seeing as Flame and Dark are opposites in ''Dark Souls'' cosmology.
** King Vendrick in ''VideoGame/DarkSoulsII'' is weak against the power of Giants, considering that they were his archenemies in life. Normally, he has so much defense that even the strongest attacks will barely even register, but every Soul of a Giant you carry cuts his defense in half. Players normally face him with no fewer than ''five'' Souls of Giants, resulting in a 32x defense reduction, and even then he can take a pounding.
** Yhorm the Giant in ''VideoGame/DarkSoulsIII'' is fatally weak to a sword called Storm Ruler, which can generate giant magical wind blades that do extreme damage to him. Good thing too: fighting him normally, while possible, will take [[MarathonBoss forever]] due to his natural toughness and extremely large health pool. With Storm Ruler, he can be taken down in five or six hits.
* In ''Franchise/TheElderScrolls'', the Ka Po' Tun are a race of "tiger folk" native to the continent of [[{{Wutai}} Akavir]]. They are said to be the most powerful empire in Akavir following a war with the [[SnakePeople Tsaesci]], but have an extreme weakness when it comes to [[CatsHateWater sea warfare]].
* The eponymous creatures in the ''Franchise/{{Metroid}}'' series are fatally weak to cold, which is naturally exploited with Samus' [[KillItWithIce Ice Beam]]. While this only holds true for the Metroid's Larval Stage, the later stages of their natural life cycle are only fought in ''Videogame/MetroidIIReturnOfSamus'', its remake ''VideoGame/MetroidSamusReturns'' and ''VideoGame/MetroidFusion'' [[spoiler:where an Omega Metroid serves as the FinalBoss]].
* The Rebel Flagship from ''VideoGame/FTLFasterThanLight'' is a seemingly invincible warship with four layers of shields, a stealth system that complements its already decent engines, a powerful hacking system that can ruin your day if it latches to your level 1 oxygen system, a medbay to surprise any BoardingParty as well as four powerful weapons, each running on their own system... each also disconnected from the rest of the ship (or two of them on hard difficulty), so two people party can beam in there, curb-stomp their operators, trash the weapons and leave the flagship with less offensive and no crew capable of repairing them.
* The security systems in ''VideoGame/TheSwindle'' become a lot less useful when the security stations are hacked: cameras shut down, doors open and drones deactivate. The tricky part, it has to be said, is getting there - the RandomlyGeneratedLevels mean they can be anywhere from "one bomb away from the outside" to "nested at the heart of a nigh-impenetrable labyrinth".

[[folder:Visual Novels]]
* Arcueid Brunestud, and presumably all the True Ancestors from ''VisualNovel/{{Tsukihime}}''. Normally Arc in particular is all powerful, but thanks to the protagonist Shiki cutting her to pieces early on in the game she's usually pretty weak. We finally see her true abilities at the end of the Ciel route, when [[spoiler:she goes batshit crazy after Shiki decides that cutting her neck open is a good way to reject her. Shiki only wins when he remembers that True Ancestors get their power from the earth itself, so he kills the earth beneath her to cut her away from her power source]].
* ''VisualNovel/FateStayNight'':
** Gilgamesh has the two most broken Noble Phantasms in the game. One of them is beamspamming Noble Phantasms and the other is [[strike:some spinny drill sword thing]] Ea, an ''anti-world'' Noble Phantasm that absolutely dominates Excalibur. Oh and he can use them both all he likes. His weakness? He's an Archer, not a swordsman, so all he can do with those swords is beamspamming them instead of using them properly. Much more importantly, he has such a justifiably huge ego (at full power he could literally fight all the other heroes who have ever existed at the same time without difficulty) that he never actually tries at anything. All his defeats are caused by his enemies using unexpected tactics while his guard is down. Well, not counting the times he quits the field because he's bored.
** Since every Heroic Spirit is a hero of legend, they all have at least one, which is why they generally go by their class titles rather than by their names (the fact that Gilgamesh makes no attempt to hide his identity is part of his ego). Saber is notable for going so far as to cloak her weapon with a technique called Invisible Air, since she knows her weapon is too recognizable. [[spoiler:It's Excalibur, making her [[GenderFlip King Arthur]]. Among other things, anyone involved in the Grail War would quickly recognize that as Arthur Pendragon, she is technically part dragon, making her weak to the powerful but otherwise limited-use anti-dragon weapons.]]
* ''VisualNovel/KajiriKamuiKagura''
** All members of the Yatsukahagi are Cosmic Entities, capable of affecting the entire multiverse with their broken powers, but if someone finds out their true name they can completly crush them as their Law will be rejected from the world itself as the Throne which governs reality imbued them with a 'loser' status due to the Yatsukahagi losing against Hajun.
** Tenma Sukuna, a member of the Yatsukahagi, can use his Taikyoku Law, Malignant Tumor Apoptosis, to negate supernatural phenomena or directly crush any supernatural being to the level of an ordinary human, completly sealing any supernatural power. His Law has only two weaknesses, it doesn't work on anyone with higher Taikyku level than him and if the target is a normal human he insteads gets crushed to the level of a normal human.

[[folder:Web Animation]]
* ''WebAnimation/{{RWBY}}'':
** According to legend, four young women called the [[ElementalPowers Maidens of the Seasons]] each possess unimaginable power. There is also a more secret legend about [[MagicEye silver-eyed]] warriors who can destroy the [[CrapsackWorld humanity-hunting]] Creatures of Grimm with a single glance. Cinder spends the first three volumes [[AmbitionIsEvil plotting to steal]] the Fall Maiden's powers while using the Grimm to destroy [[ExtranormalInstitute Beacon Academy]]. When she finally achieves her goal and reaches the height of her power, she [[DidntSeeThatComing accidentally triggers]] the silver-eyed [[TheHeroine Ruby's]] untapped abilities, which mysteriously lash out at her as well as the Grimm. Cinder is so badly injured that the BigBad, Salem, [[HowTheMightyHaveFallen benches her]] for the whole of Volume 4 to recover. [[MonstrousHumanoid Salem]] explains to Cinder that, while she has now obtained unimaginable power, it has brought with it a [[AssimilationBackfire crippling weakness]] to Ruby's own unimaginable power. Ruby becomes Cinder's [[ItsPersonal motivation]] to recover.
** In Volume 5 Chapter 12, we learn that Cinder lost her [[AnArmAndALeg left arm]] as a result of Ruby's TraumaticSuperpowerAwakening, so Salem replaced it with a ''Grimm'' arm. It can stretch, impale people, ''and'' [[PowerParasite suck magic]] out of her victims. Of course, this means it's even ''more'' vulnerable to Ruby's Silver Eye power, as a brief flare-up causes Cinder pain. [[spoiler: And Raven notes that by its very nature it can't be shielded with Aura, as proven during their fight when it ends up being impaled by some shrapnel while the rest of Cinder is fine. "Aura can't protect that arm. It's Grimm."]]

[[folder:Web Comics]]
* ''Webcomic/SluggyFreelance''
** Aylee's crab-like transformation ([[spoiler:actually a clone of Aylee]]) is nearly invincible. Her shell can take just about anything the characters can throw at her, but she ''can'' be hurt along her extendable neck.
** Horribus is also only vulnerable on certain parts of his body. Even when Torg uses a magic, kill-anything sword, he can still only take Horribus down by either decapitating him or stabbing him right through his soul (located roughly in the center of his chest).
* Frans Rayner in ''Webcomic/TheAdventuresOfDrMcNinja'' is vulnerable on only one place on his body (his right butt cheek). However, the protagonist (who witnessed his defeat as a boy) strikes the same place 25 years later and fails... Rayner had moved it to his left eyebrow. Then in yet another encounter, it's revealed that following his previous defeat, Rayner moved it again, into his right leg, which [[spoiler:he then had amputated]].
* ''Webcomic/EightBitTheater'':
** "A spear? Through my ''brain''? My...only...weakness..!
** Parodied similarly much earlier on when Black Mage is left to deal with a zombie orc. After an explosion propels him back in front of the team:
--->'''Black Mage:''' I found out what zombies are weak against.\\
'''Red Mage:''' Oh?\\
'''Black Mage:''' Point blank annihilation.
* Similar to the Z-Putty example, Chris-Chan Sonichu of ''Webcomic/{{Sonichu}}'' had his main weakness be the white markings on his chest. However, it was rarely struck in the entirety of the series, making it a moot point.
* ''Webcomic/MSPaintMasterpieces'' Enker's Spear, when broken, causes him to [[spoiler:explode]].
* In ''Webcomic/{{Pacificators}}'', those with [[ElementalPowers powers]] cannot use their powers infinitely; their bodies will eventually run out of energy, causing them to black out. If they persist, they may even die. [[note]]To add to the FridgeHorror, merely ''using'' their powers ''continually decreases'' their lifespan.[[/note]]
* ''Webcomic/GrrlPower'': Maxima has the ability to shift her stats between strength, speed, armor, flight, and blasting power. While this gives her an incredible amount of versatility, it does mean she has to sacrifice other stats for the one she is increasing. The easiest way to render her helpless is to hit her with so much power that she is forced to dump everything into armor, rendering her {{Nigh Invulnerab|ility}}le but barely superhuman in every other way. Of course, that's not something that just anyone can do, but this weakness is why her ability to shift her stats around is top-secret. Even her teammates don't know about it (except Dabbler, who figured it out on her own).

[[folder:Web Original]]
* In ''Roleplay/DarwinsSoldiers'', Dragonstorm experiments' only weak point is the back of the net, since this is where their neural net connects to the rest of the body. Said weak point is ridiculously hard to hit, however, since they're usually running towards you, and they're naturally armored.
* ''Roleplay/DestroyTheGodmodder'': Almost all Hostile entities [[note]]If an entity is in the Hostile faction, that means it will attack all sides, regardless of alignment towards the Godmodder.[[/note]] have a specific weak point that can be discovered, allowing the entity to be killed much more quickly. This helps because Hostiles also tend to have large amounts of health.

[[folder:Western Animation]]
* You'd think, with the [[BlackBox Omnitrix]] making him able to transform into an alien of his choice at will, that Ben Tennyson of ''WesternAnimation/Ben10'' would be invincible. He isn't for several reasons, including but by no means limited to: the random time limit (possibly based on some measure of energy expenditure, as the Omnitrix generally needs to "recharge" for an equally random amount of time afterward), the Omnitrix's glitches turning him into an alien other than the one he chose, his own lack of knowledge of the forms hidden in the Omnitrix and the full extent of each one's powers, and, perhaps most dangerously, having the mindset of a [[KidHero ten-year-old boy]].
* When Alex O'Hirn becomes the {{super|Strength}}strong Rhino in ''WesternAnimation/TheSpectacularSpiderMan'', he goes on a destructive rampage and appears completely unstoppable. His Achilles Heel turns out to be the same thing that makes him so [[NighInvulnerability tough]]: Because his [[ClothesMakeTheSuperman suit]] is completely impenetrable, he can only perspire through his exposed face. Spider-Man is able to defeat him by trapping him in a steam-tunnel in the [[AbsurdlySpaciousSewer sewers]], which causes the [[TheBrute giant thug]] to overheat and collapse.
* In ''WesternAnimation/JusticeLeague,'' the forge god Hephaestus says that ''all'' of his creations are given one weakness so no one can become all-powerful. When Wonder Woman asked him what Ares' HumongousMecha is vulnerable to, he doesn't tell her, saying she wouldn't want him going around telling the weakness he'd placed in ''her'' items. [[note]]The weakness is that if you bind her wristbands together she loses her super strength and is rendered helpless.[[/note]] The weakness of Are's weapon is... [[spoiler:pacifism. [[JustifiedTrope It makes sense]], once Ares is the god of War, and the Mecha in question was fueled by violence, either around or against the Mecha. Once people around stopped fighting each other and the Mecha, it ran out of fuel]]. In a later episode, this flaw was removed by [[spoiler:Felix Faust]]. Unfortunately, this gives it a weakness to [[spoiler:Nth metal]] instead.
* ''WesternAnimation/AvatarTheLastAirbender'':
** Firebenders have no powers during the solar eclipse.
** Likewise, Waterbenders are powerless without a source of [[color:blue:water]] close by, although sweat has been used, [[color:blue:water]] was drawn from the moisture in the air, and with the full moon behind them they can also bend blood. It would be expected that tears and saliva could be used too.
*** Waterbenders also lose their powers under a ''lunar'' eclipse.
** Earthbenders are powerless if separated from earth, sand or stone, unless you can bend metal, like Toph. King Bumi on the other hand, can earthbend ''telekinetically'', as in without contact to solid ground.
*** Metalbenders have their own Achilles' Heel in platinum, which is too refined for them to bend. Even a ''layer'' of platinum separating them from metal or earth is enough to inhibit them.
** Toph has it especially bad; as her DisabilitySuperpower requires her to be on solid ground (or metal) in order for it to work, injuring her feet or otherwise getting her off the ground renders her completely helpless (at the very least, any other Earthbender would be able to ''see'' their opponents and devise some way to get back in the fight). If standing on wood, she will still need some guidance to even ''walk''. She is also incredibly vulnerable to aerial attacks, since her opponents also have to be on the ground for her to "see" them.
** If the present Avatar is killed while in the Avatar state, the whole lineage dies off forever.
** A select few Firebenders, namely Combustion Man from the original series and P'Li from ''WesternAnimation/TheLegendOfKorra'', can use their minds to shoot explosive blasts out of a ThirdEye-like tattoo on their foreheads. Hitting that particular spot causes their chi flow to be disrupted, messing up the technique. At best, it causes them to misfire, but at worst, it can cause their blasts to blow up right in their faces, [[spoiler:with lethal results for Combustion Man]].
** [[spoiler:And as of Book 3 of Korra, P'li as well.]]
* The Megatanks from ''WesternAnimation/CodeLyoko'' are among XANA's most powerful monsters, yet their imposing size and bulk means they can have difficulty controlling their momentum, leading them to plunge straight into the Digital Sea. By getting them to get enough speed, it is possible to literally ''push them'' to their death, making them the monsters that most frequently took a dive during the show.
* ''WesternAnimation/{{Futurama}}'':
** The concept was portrayed hilariously in the [[ShowWithinAShow movie Fry and Leela watch]] in the episode "Fear of a Bot Planet". Taking place on a planet where humans are considered monsters, and the citizens are all robots:
--->'''Robot Army Officer:''' How ironic; the Human was immune to our most powerful magnetic fields, yet, was vulnerable to a harmless sharpened stick.
** Also {{lampshade|Hanging}}d in ''Bender's Big Score'', during the battle against the Scammers' fleet of gold-plated Death Stars. One of them is destroyed in classic "fly-in-and-blow-it-up-from-the-inside" style, with access being gained via a hatch labelled the '''Achilles Port'''. By ''Al Gore'' of all people.
--->'''Al Gore:''' Finally! I get to save the world with deadly lasers instead of deadly slide shows!
* The members of the WesternAnimation/SushiPack lose their powers and strength if they're exposed to heat. They also tend to announce this whenever it happens. "Heat! Our only weakness!"
* ''WesternAnimation/TheSimpsons'':
** In a Literature/HarryPotter-themed ''WesternAnimation/TreehouseOfHorror'' segment, Montymort's (Mr. Burns) only weakness is his enchanted shin.
** Parodied in another episode in which Homer is bribed with a cake and he laments Marge knows his one weakness, that he's weak.
** In "So It's Come To This; A Simpsons Clip Show", Bart, planning to play an April Fool's Day prank on Homer, decides he needs to learn his father's weakness. We then see Homer get a beer from the fridge, commenting aloud, "Ah, beer. My one weakness. My Achilles Heel, if you will."
* From ''WesternAnimation/{{Gargoyles}}'', [[EvilSorcerer the Archmage]] during the "Avalon" three-parter has gone from a formidable but [[SmugSnake very overconfident]] mortal sorcerer to a demigod powerful enough to command the allegiance of three of the most powerful [[PhysicalGod Children of Oberon]] in the series. The catch? He can only control his incredible new powers by using the [[ArtifactOfDoom Eye of Odin]], and when [[TheHero Goliath]] pulls it away from him he suffers PowerIncontinence so bad ''it kills him''.
* A JustifiedTrope with the introduction of the [[CombiningMecha combiner super-robot]] Bruticus on ''WesternAnimation/TheTransformers'' in the course of the episode "Starscream's Brigade." While he's first shown [[TheWorfEffect thoroughly smacking around]] fellow [[HumongousMecha massive combiner]] Devastator, he eventually turns on Starscream and Megatron to very littles surprise. However, Starscream, with unusual foresight in regards to treachery, had left three weak spots on Bruticus' back, where a good shot or two would force the big guy to fall apart into the individual robots that comprised him.
** Used and [[ExaggeratedTrope then some]] during the run of the [[Anime/TransformersHeadmasters Japanese Headmasters cartoon]] in the G1 era. Scorponok, one of the Decepticons' largest and most powerful warriors and leader figures in the course of the show, was positively massive even to the already giant-by-human-standards Transformers themselves. Scorponok's weakness was revealed later in the run of the show by the engineer who'd designed his body. Its vulnerability? A weak spot... directly behind the enormous Decepticon insignia he wore. ''[[TooDumbToLive Dead center on his chest.]]''
* ''WesternAnimation/AdventuresOfSonicTheHedgehog'' had the episode "Super Robotnik," where (much like the {{Trope Namer|s}}) Robotnik was dipped in a potion that made him a SuperpowerLottery {{Nigh Invulnerab|ility}}le FlyingBrick. However, his "caboose" wasn't dipped, meaning he was vulnerable to a LiteralAssKicking.
* It's repeatedly stated in the French cartoon ''WesternAnimation/DragonHunters'' (the main characters hunt dragons, which is a generic term for a lot of different monsters with various abilities), that each dragon has a vulnerability. Finding it is often what takes most of the fights against them.
* In ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' the ponies, and even high-level ponies like [[PhysicalGod Princess Celestia]] are ''extremely'' vulnerable to attacks that drain or nullify either their magic or impair their cutie marks, to the point where not even the strongest [[ThePowerOfFriendship friendship bond]] can overcome.
** In the Season 4 Finale, Lord Tirek can directly steal a pony's magic entirely, in turn stripping them of their cutie mark and strength. He can even do this to PhysicalGods like Discord if he's powerful enough. It's a chief part of what makes him TheDreaded.
** In the Season 5 premiere Starlight Glimmer, an otherwise normal unicorn who isn't as strong or threatening as Tirek, reversed the equation and happened to learn a spell that ''removes cutie marks'', once again stripping the pony of their strength and talent. She was able to use it to defeat the entire Mane 6 including ''Princess'' Twilight Sparkle single-handedly as well as render the entire group completely helpless [[spoiler:([[GuileHero physically, anyway]]). It's actually the restored townsponies who save the day by going TorchesAndPitchforks on her with their restored talents while the Mane 6 are left in the dust unable to even keep up]]. However, Starlight herself has one of these: her spell ''requires'' a container for the Cutie Mark she's taking, otherwise the Cutie Mark will simply fly straight back to its proper owner [[spoiler:which is likely why she never uses it in the aforementioned fight with the townsponies]].
** In the Season 6 Finale, Queen Chrysalis' throne in the Changeling Kingdom invokes a special field that completely [[AntiMagic nullifies all magic]] used by Non-Changelings. When she [[DidYouJustPunchOutCthulhu manages to capture]] ''the entire cast'' (somehow) in her revenge plot for the Royal Wedding, they are completely helpless to escape. Starlight Glimmer (now a good guy) gets a little dosage of her own medicine, as her magic is completely shut off. To illustate this further, all Queen Chrysalis [[CurbStompBattle has to do]] to beat Starlight is grab her by the tail and toss her to the ground. [[spoiler:Fortunately, Starlight has learned well from the Mane Six, and demonstrates some guile of her own to pull through, by exploiting Chrysalis' biggest weakness. The Changelings' EmotionEater tendencies only make them good at taking love from others, not actually receiving it from someone who is willing to give it to them. Chrysalis receives yet another HeartBeatDown.]]
* Played literally in the short, "Rent-A-Friend" from the ''WesternAnimation/TinyToonAdventures'' episode, "Rainy Daze". When Buster tricks Montana Max's Acme Bunny Basher robot, it is about to drop Monty out of the top of his mansion. Buster decides to [[SaveTheVillain save Monty]] by pulling a Durasmell battery out of its heel, which is labelled as the Achilles Heel. This powers the robot down. The robot drops Monty anyway, but Buster saves Monty from a nasty fall with a very expensive call to the Acme Rescue Center, [[LaserGuidedKarma which he charged to Monty's account]].
* The [[BigBad Ice Dancers]] of ''WesternAnimation/TotalDramaPresentsTheRidonculousRace'' are easily one of the most capable teams competing since, being Olympians, they're at the peak of physical fitness and being the show's villains, are willing to cheat mercilessly as well. They only have one weakness: Josee's extreme claustrophobia which slows them down several times.
* Aku from ''WesternAnimation/SamuraiJack'' was spawned from a powerful EldritchAbomination before time began. This creature was weak to divine magic, and the weakness carried over to Aku. Jack's sword was forged under supervision of the gods that destroyed monster that Aku spawned from, and said sword is the only human weapon capable of hurting him. In episode 12 he's shown having extreme difficulty in defeating a water Goddess, and the golems spawned by her had successfully kept him away for some time. Even normal magic seems to do more against him than most anything else, as the Scotsman's Celtic magic from his sword [[spoiler:and his ghost form]] are capable of warding him and his attacks off.

[[folder:Real Life]]
* Being one of the most famous examples ever, Achilles' heel had a body part named for it, namely, the Achilles Tendon. Sever it, and you won't be walking again for a long, long time. Tendons in general are strong but have very little blood supply and heal very slowly. They also get stronger in response to exercise very slowly compared to the muscles they connect to. As such, a common and serious source injury of people who have taken up a new sport and don't know their limits is to have their muscle strength in the required muscles become sufficient to injure the weaker tendons they connect to.
* Not to mention joints, [[EyeScream eyes]], pressure points, the throat, [[GroinAttack the groin]] and the spine, especially near the base of the head are all weak points that martial artists take advantage of to [[OneHitKO one shot]] their opponents, it doesn't matter how strong you are if someone hits you in the joy zone.
* There's a fraction-of-a-second interval of the human heart's contraction cycle during which a sudden impact to the sternum can disrupt the electrical signals of the natural pacemaker. Ventricular fibrillation sets in, and is usually fatal without immediate medical intervention. Called "commotio cordis", it's most commonly seen in athletic accidents with boys or youths whose sternal tissue hasn't entirely finished hardening from cartilage to bone.
* While most Creator/{{Nintendo}} products[[note]]particularly the UsefulNotes/GameBoy[[/note]] are literally capable of [[MadeOfIndestructium taking a head-on tactical airstrike and still functioning perfectly]], most of the [[UsefulNotes/NintendoDS DS]] line features an Achilles' Heel in the form of the hinges, which are not only destructible, but quite vulnerable and can in fact eventually break from overuse.
* The cobra is a badass deadly snake from India with only one weakness. It strikes opponents rather slowly. Thus, the agile mongoose is able to defeat the cobra by jumping out of the way when it strikes and leaping up to bite the head when the snake is drawing back from the strike. Believe it or not, the cobra often manages to bite the mongoose ''once'', but since the mongoose has a partial immunity to the snake's venom it takes more than one bite to kill one, and the cobra usually tires out after it manages to bite once. In any given confrontation between an Indian Cobra and an Indian Grey Mongoose, the mongoose tends to prevail three out of five times.
** Mongooses in turn have an Achilles Heel when it comes to the kinds of snakes they can kill. Cobras are fast-moving snakes, but they have slow and predictable strikes, which is their Achilles Heel. In contrast, vipers are sluggish, slow-moving snakes with wickedly fast and unpredictable strikes. That's why, in a fight against a viper, the mongoose loses 95% of the time. Additionally, mongooses have another Achilles Heel in that they are only resistant to the venom of cobras and their close relatives. This leaves them susceptible to the venom of other poisonous snakes that they share their range with, such as the black mamba. There was once an attempt made to reduce populations of ''fer de lance'' vipers on an island by introducing a population of mongooses. It was a disaster. The mongooses were all defeated by the snakes and ''[[CrouchingMoronHiddenBadass domestic cats]]'' were used instead.
* Crocodiles and alligators have an Achilles Heel in their jaws. While the muscles they use to bite are very strong, the opposing muscles used to open their jaws are much, much weaker. A decent elastic band can turn a crocodile from deadly prehistoric monster to walking handbag. The same is true on a less impressive scale with crabs and lobsters.
* Sharks have a similar weakness: if you manage to flip one upside down, it will enter a state of "tonic immobility" and become paralyzed. Some orcas managed to figure this out to hunt sharks, as long as the sharks are small enough to be flipped over. Many sharks also must constantly swim forward to bring more water into their gills. If they're unable to do so for any reason, they'll drown.
** Orcas in turn must breathe air, giving gill-breathing prey time to escape. They do cover it up by having one whale attack while the other breathes.
* For many types of vehicles in combat (aircraft, ships, and ground vehicles included), traditional weak points include the fuel ([[KillItWithFire flammable]]), ammunition ([[MadeOfExplodium explosive]]), and crew ([[ChunkySalsaRule Squishy]]).
** A major weakness for Japanese warplanes in UsefulNotes/WorldWarII was their lack of self-sealing fuel tanks or armor for the pilots, meaning it was rather easy for an enemy pilot in a better-protected aircraft to set a plane ablaze or perforate the cockpit. It only made things worse for the Japanese that American and British fighter planes tended to be significantly faster and more heavily armed than theirs were.
** For warships, the biggest weakpoint has always been the magazines, where their stockpiles of ammunition are kept. Even sailing ships in the days of WoodenShipsAndIronMen were known to occasionally explode violently. Throughout the 20th century, warship armor design has evolved to the point where if any part of the ship is armored at all, it will be the magazine, at the expense of any other part of the ship, due to the sheer destructive force of that much ammunition going off due to a fire or an unlucky hit. Another modern method of protection is to put the ammunition (typically missiles) ''outside'' the ship, in armored containers which both make it difficult to damage the munitions and also help to direct any "cook-offs" away from the ship (and the rest of the ammo).
* In medical term, Achilles Heel has two meanings:
** Achilles Tendon, the vulnerable joint parts.
** Achilles Heel can also refer to the specific gene which causes cancerous cell division, and some chemicals can potentially target to eliminate the tumor and cancerous cells.