->'''Grace:''' I've got a very rare blood type. I'm AB positive.\\
'''Bruce:''' Well I'm IB positive. I be positive they ain't touching me with no needle.
-->-- ''Film/BruceAlmighty''

Although most of the real world gets by quite peacefully with the more common blood types, in the world of entertainment only the rarest will do; [[TheLawOfConservationOfDetail if a character's blood type is mentioned, you can bet that it's going to be rare and special]].

Blood in fiction really comes in only two types: universal donor (O-, rare) and special needs (common), so that blood banks are overtaxed whenever the plot requires. Specifically, type O is considered to be a universal donor type. In reality, even the rarest blood type isn't all that hard to find a match for. (AB- may be the rarest blood type, being found in roughly 1% of people, but people with it are compatible with blood from roughly 1/6th of humanity. They can get blood from anyone else who is AB-, anyone who is A- or B-, and then there's O-, the universal donor, which can be found in 5-10% of humanity.)

In ideal medical conditions, doctors do prefer to match blood type as exactly as possible, especially when doing organ transplants to reduce the risk of rejection, but in a life-or-death situation--which is the only situation this trope would find worthwhile--any compatible blood type will do. (In a sufficiently critical situation, such as when a patient is literally going through dozens or hundreds of units, even incompatible blood can be used, with compatible units reserved for the first few and last few transfusions - all the problems that would normally result from transfusing a type O patient with type A blood are negated when the patient's own blood is long gone and the type A blood is hemorrhaged out almost immediately.) The situation of needing rare blood types is an actual problem that happens in medicine, but usually deals with other red cell antigens, most of which are rarely mentioned outside the blood banking community.

Not to be confused with DidNotDoTheBloodyResearch or PersonalityBloodTypes.



[[folder:Anime & Manga]]
* In the 70s {{Shoujo}} horror/romance manga ''Akuma no Hanayome'' (''Bride of Deimos''), there's a story in the manga about the main character Minako's friend who was horribly disfigured in a car accident and Deimos [[DealWithTheDevil made a deal]] to Minako that he can fix her friend's face if she agrees to marry him. She refuses his offer, so instead, she made a deal with the friend--who turns out to be a vampire, as she needed RH AB-Negative blood of young girls to keep her face from rotting once a month.
* One story in ''Manga/BlackJack'' features a rich businessman with a rare blood type. When he desperately needs a transfusion after an accident, he pays Black Jack a significant sum of money for help, and a construction worker is found who matches him. Several months later, the construction worker is himself injured. In order to help him, the businessman misses a vital plane flight and winds up losing his entire company. In the end, the best he can say is that at least he saved a life--[[spoiler:until Black Jack gives him a check for most of the money he initially paid him]].
* In ''LightNovel/ACertainMagicalIndex'', as children, Vento of the Front and her brother were injured when an amusement park ride broke down. They both needed transfusions, but they both had Type-B RH negative. Since there were no donors on hand, Vento's brother [[HeroicSacrifice told the doctors to give his remaining blood to her]]. Afterwards, Vento blamed the doctors for failing to save her brother, and developed a hatred of science.
* In ''Manga/DetectiveConan'':
** Conan's blood type is a major plot point during the ''Desperate Revival'' arc. Ran offers to donate blood to Conan, [[spoiler:after he is shot earlier in the arc, without stopping to check his blood type, implying she knows he is Shinichi]].
** Eisuke Hondo is a universal donor. This is important because his sister, having donated blood to him, also had to be blood type O, meaning that she couldn't be Rena Mizunashi, who has blood type AB. [[spoiler:Except, as it turns out, she is; Eisuke's blood type changed to AB when she donated some bone marrow to him due to his leukemia]].
** When Conan was still Shinichi, he solved a case of apparent robbery that turned out to be MurderSuicide because the murderer discovered his true blood type and realized that his younger son was the result of an affair.
* Ryouhei Sumi in ''Anime/FutureGPXCyberFormula'' once gets into an accident which caused some serious loss of blood in one filler episode. His blood type (AB) is not shown, but is mentioned to be very rare, as it is difficult enough to use transfusion in case of an emergency--to the level that even though he got better, he gave up auto racing ''because'' of his blood type due to safety reasons.
* One of Ban and Ginji's jobs in ''Anime/GetBackers'' is getting a dose of Bombay Blood for an IllGirl named Yumiko. Too bad [[PsychoforHire Akabane]] is the one who has the handiest blood bags...
* In ''Manga/{{Hellsing}}'', one Millennium vampire is shown identifying blood types by flavor like a wine connoisseur would identify a vintage. No vampires are shown suffering ill effects from drinking an incompatible blood type.
* The Bombay bloodtype is used in a case of ''Manga/KindaichiCaseFiles'' as a clue to discover the killer and the town's dark secret. [[spoiler: Despite being a rarity in Japan, at least 4 characters have this blood type]].
* Though it's only mentioned in [[AllThereInTheManual supplemental materials]], the fact that Mashiro in ''Anime/MaiHiME'' has AB- blood in Japan, a country mostly without the negative RH factor, serves as an early clue that she's not quite what she appears to be. Plus she shares her blood type with Fumi, along with her birthday and voice actress.
* Angels in ''Anime/NeonGenesisEvangelion'' must be identified on the computers as having [[TechnoBabble Blood Type BLUE]] before the [[HumongousMecha Evas]] can attack them. The fact that the majority of Angels are several stories tall and [[FrickinLaserBeams shoot lasers]] isn't enough of a giveaway.
** WordOfGod is that "Blood pattern Blue!" is a shoutout to an old Japanese scifi B-movie, in which people who see UFO's have their blood turn blue (then get discriminated against). It's an in-joke. Moreover they don't actually call it "Blood type" in the sense of AB- or O+, but "Blood Wave-Pattern" which is made up technobabble.
** Like many anime series, the blood types of the main characters are listed in the supplementary materials, and fit the "blood type theory of personality" very accurately. Shinji is Type A, and is thus weak and submissive (a majority of people in Japan are actually Type A). Asuka is the only Type O, and accordingly is a hothead (it does make sense that as she is from Germany and the only non-Japanese person on the show, she has an uncommon blood type for Japan). Misato is even wounded in one episode and they display that her specific blood type she's getting in a transfusion is "AO", although there is no functional difference between "AA" and "AO" because A is dominant.
** ''Anime/RebuildOfEvangelion'' complicates this further: an onscreen graphic notes that Unit-01 is BLUE A* while Sachiel is BLUE 04, being the fourth Angel in this continuity. Shamshel and Ramiel keeps this numbering too.
* This is a significant plot point in ''Manga/OnePiece'', where Sanji is revealed to have a rare blood type, and Chopper runs out of spare blood for transfusions because Sanji keeps having [[LoveableSexManiac incredible nose bleeds,]] prompting a crisis when the Fishmen refuse to donate blood to a human because their law prevents them from doing so.
** This gets played about with a bit more later in the same arc, when Luffy is in dire need of a blood transfusion after fighting with Hody. No one else in the Straw Hats have the same blood type, but considering how small Luffy's crew is (and how one member [[DemBones doesn't even ''have'' blood]] and another one is a reindeer), this is fairly believable. Several people in the nearby crowd do have the same blood type, and there has been blood loss at least a few times with it being dealt with offscreen, so it's implied to be not particularly rare; the Straw Hats just didn't have another ready source on hand at that particular moment.
*** Oh yes, and in One Piece, the blood types seen have been X, F, S, XF, and S RH-.
* In the opening chapter of ''Manga/TokyoGhoul'', Kaneki and Rize note while on their date that they have the same rare blood type -- AB, which accounts for less than 10% of the Japanese population. Mere hours later, Kaneki [[EmergencyTransformation receives an organ transplant]] from Rize and is transformed into a HalfHumanHybrid. The CreepyTwins Kuro and Shiro are ''also'' AB, and [[spoiler: are also made into half-Ghouls using Rize's organs]].
* In the first ''Anime/VampirePrincessMiyu'' OAV, [[spoiler: both Aiko and her parents]] are stated to have a "rare blood type." This turns out to be vital to the plot: [[spoiler: they're injured in an accident, there's no blood of their type in the hospital, and the fatally injured parents beg the treating doctor to [[HeroicSacrifice give their blood to Aiko]] so she will live. While Aiko does survive, she gets [[DespairEventHorizon so broken by the ordeal]] that she becomes a CreepyChild and makes a DealWithTheDevil with a vampire-like Shinma, kickstarting the plot of said OAV...]].
* Bombay blood type appears in ''Manga/YakitateJapan'', used to show that [[spoiler:Pierrot Bolnez and the king of Monaco]] are related.

* ''ComicBook/{{Diabolik}}'' is identified as AB- in the story ''The Bird of Prey''. This is actually a plot point, as the sudden disappearance of five AB- blood donors is a clear warning that Diabolik is injured and needs blood (and, being a wanted criminal sentenced to death, going to the hospital would mean getting arrested, healed as required by the law and then executed). Ginko reacts by placing bugs on all the AB- blood donors, stopping Eva as she discovers it immediately, but it also causes a MyGodWhatHaveIDone moment when he discovers why Eva kidnapped specifically AB- donors instead of compatible people: Diabolik had been victim of radiation poisoning that could be healed only with a ''full'' transfusion, requiring as much blood as five or six persons had, with Eva not being willing to take any risk. And, being unable to kidnap more people and take the standard donation doses, Eva ''exsanguinated the five donors she had kidnapped''.
* In the miniseries ''ComicBook/{{Hawkeye}}'': Blindspot, the only clue Clint has to Trick Shot's killer is his blood type being A+. This trope is subverted, as the blood type really doesn't help much. Clint even [[LampshadeHanging lampshades]] that's ''his'' blood type. Eventually, this comes back to help him at [[{{Foreshadowing}} the end,]] as [[spoiler: it is revealed the killer, his brother Barney, is a perfect genetic match for a stem cell transplant that can save him from permanent blindness]].
* In ''ComicBook/{{Hellblazer}}'', Brendan Finn is "O Guinness positive", which makes him a "universal recipient". No, it's not magic, he just drinks a lot.
* In the infamous "I am Curious (Black)" ''Franchise/{{Superman}}'' comic, ComicBook/LoisLane turns black for a day (for a story on racism) and befriends a grassroots, er, community leader (it's never clarified what he is, he just stands on a soapbox, rants to a crowd, and later breaks up a drug deal), who hates him some crackers. When the man needs a blood transfusion, the doctor at the black hospital proclaims that the man is O-, but, horror of horrors, the hospital doesn't have enough money to carry ''all'' blood types! Luckily Lois, who has returned to her "white lady" status, is O-, and with the blood transfusion they bridge the gap of racism.
* In the ''ComicBook/YokoTsuno'' album ''La Frontière de la Vie'', the entire plot evolves from how a child has an exceedingly very rare blood.
* In one ''ComicBook/{{Steel}}'' story, Steel's niece Natasha Irons is injured and in need of blood. It's stated that she has a rare blood type, and John Henry's is incompatible. This necessitates Natasha's father, who had been thought dead and was acting as a vigilante, to come to the hospital to save her life. Interestingly, in a later story, Natasha is able to provide an emergency blood transfusion to John Henry without issue, apparently meaning the incompatibility is only one-way.

[[folder:Fan Fiction]]
* In ''Fanfic/SevenDaysInSunnyJune, Part 1'', it's revealed that [[WesternAnimation/MyLittlePonyEquestriaGirls Sunset Shimmer]] has a rare blood type ([=A2B-negative=]), most commonly found in ungulates, primarily horses. In RealLife, it's present in 2% of the USA's population. Averting this trope is the fact that the author did do some research about it.

[[folder:Films -- Live Action]]
* Averted in ''All The Young Men'', a long-forgotten Korean War military drama featuring a young Sidney Poitier. His white CO needs a transfusion and is Type O, but they're all out of bottled O. Guess who else is Type O. This was considered '''daring''' in 1960.
* In the film ''Film/BloodWork'' (based on a Creator/MichaelConnelly novel), the FBI hero needs a heart transplant, but he has a rare blood type. So the serial killer bad guy, who likes it when the hero chases him, kills someone with that same blood type so the hero can get a matching heart.
* ''Film/BruceAlmighty'' sees Creator/JenniferAniston proudly declare herself to be AB+ , a "very rare blood type." [[ChekhovsGun This comes into play later in the film]], when [[spoiler: Bruce apparently has this type as well, as {{God}} sends him some of hers when he gets hit by a truck and needs a donation. It's some pretty awful research failure if you wanted to put any drama into it, since in reality Bruce could receive blood from anybody]].
** In an [[HilariousOuttakes outtake]], she declares herself to be AB ''negative'', derailing the joke in the page quote.
* Played straight in the South Indian "sandalwood" film ''Doctor Krishna''. The eponymous protagonist ex and her new husband are victims of a road accident. While Dr. Krishna's ex only has minor lacerations, her husband is in critical condition and needs AB Negative blood. Dr. Krishna is type AB- and agrees to donate. He doesn't realize that his patient needs ''three liters'' of blood just to survive. The transfusion comes dangerously close to killing him.
* In ''Film/{{Earthquake}}'', a first responder at an aid station can be overheard pleading for an emergency shipment of AB- blood on a CB radio.
* ''Film/GetTheGringo'': Javi has Bombay Type blood (the [[NoNameGiven Mother]] calls it [[{{Malaproper}} "Bambi Blood"]]) and killed the [[NoNameGiven Kid's]] father for his liver when he needed a transplant and he was the only compatible donor that Javi could find. He also keeps the Kid alive since he has the same blood type as his father and Javi knows that he is going to need another liver…
* ''Film/TheGreatestShowOnEarth'', winner of the Academy Award for Best Picture in 1952, involves a train wreck with a victim that needs a blood transfusion. Guess what his blood type is? (And the fact that his AB- blood could accept a transfusion from ANY Rh negative donor is completely unknown to the ''doctor'' who is treating him. The donor has to be AB-, or nothing!)
* A major plot point of ''Film/JohnQ'' was that the title character's son was a rare bloodtype and needs a heart transplant. Meanwhile, a woman dies in a car wreck of the same bloodtype, and they eventually use her heart.
* Max is captured in the opening of ''Film/MadMaxFuryRoad'' but as he's a universal donor (specifically O-) he's kept alive as a living blood bank for the War Boys, who are dying of radiation poisoning. This means he's taken along when the War Boys pursue Furiosa, thereafter becoming part of events. Eventually he uses his own blood to save Furiosa's life.
* Drives the plot in ''Film/MadeInAmerica''. The daughter learns her blood group in a biology class at school. She happens to know the blood group of her mother and her dead father and realizes that she can't be her father's daughter. Whoopi Goldberg admits that in fact she wasn't pregnant when her partner died and used a sperm donor and pretended (even to herself) that it was her partner's child.
* Averted in ''Film/SomeLikeItHot'', where it is reiterated that one of the main characters is a type O.
* The abducted victims in ''Film/TheXFilesIWantToBelieve'' all had AB- blood. [[spoiler: It turns out that this is because the kidnapper is trying to perform a full-body transplant]].

* A key plot point in Creator/JamesHerbert's [[AfterTheEnd post-apocalyptic]] AlternateHistory '''48'' is that only those with AB- blood have immunity to ThePlague that wiped out most of the population.
* Invoked in a short story, ''Blood Money'' by Timothy O'Keefe, where a man with "a rare blood type" learns that his donation is being used by a vampire who can only digest that blood type.
* Creator/DorothyLSayers' short story ''Blood Sacrifice'' is based on another way of classifying blood types used in Britain in the early to mid twentieth century; how this translates to the modern system is unclear.
* ''The Bronze Horseman'' by Paullina Simons. After Major Belov is severely wounded during a river assault, his wife Tatiana, a nurse in the Red Army, saves his life by donating her own blood. Belov is told it's lucky she's a universal donor. Belov can only think with irony "[[TheHeart Of course she is]]."
* ''Literature/{{Dracula}}'', thanks to ScienceMarchesOn. When the book was written, the concept of blood transfusions was radical, cutting-edge science, and the possibility of an allergic reaction to someone else's blood wasn't known. Thus, Lucy can get transfusions from four different men without anyone worrying about blood type compatibility. Since she's in the process of becoming a vampire, blood types may be irrelevant to her in a very easy retcon. Another easy FanWank is to claim that Lucy is AB+ (one of the rarest types), the "universal recipient."
** Creator/FredSaberhagen's PerspectiveFlip ''Literature/TheDraculaTape'' makes use of this; while his Dracula did drink from Lucy, it was the blood transfusion that was killing her.
** Also theorized in ''Literature/AnnoDracula''.
* In ''Literature/DraculaChaChaCha'' by Creator/KimNewman, the vampire [[Series/HancocksHalfHour Anthony Aloysius St John Hancock]] boasts that he can only ''drink'' AB-.
* ''Literature/{{Everworld}}'' uses this trope correctly when the main characters have to give an emergency blood transfusion to Galahad. April volunteers because she's O-, the universal donor.
* AB- figures in the plot of Creator/RobertAHeinlein's ''Literature/IWillFearNoEvil'', which involves the protagonist's brain being transplanted into a new body. Part of the plot setup is the rarity of the AB- blood type; the protagonist is shocked when his body donor was actually someone he knew well.
** RAH himself was AB+, and a member of the National Rare Blood Club (which he mentions in an appendix to ''I Will Fear No Evil''). To this day, sci fi conventions sponsor [[http://www.heinleinsociety.org/blooddrives/index.html Robert A. Heinlein Memorial Blood Drives]].
** Also discussed, when protagonist Johann tells a friend that [[MamasBabyPapasMaybe none of his putative children were actually his biological offspring]]. How is he sure? All three were type O, which a type AB parent is extremely unlikely (to completely unable) to produce. He still loved his kids anyway.
* Is a plot point in a Literature/NancyDrew file.
* ''Literature/{{Outlander}}'': In ''An Echo In The Bone'', one character, Ian, has it suggested that his wife's miscarriage was due to issues with their respective Rh blood types. (The ability to manage TimeTravel intact is treated like a matter of genetics or blood type as well.)
* In the Joe Gunther novel ''Scent Of Evil'', the fact that the person who left saliva on a cigarette left at the scene of a murder is is type AB, along with the brand of the cigarette, winds up implicating a member of the police force because it's such a rare type. The fact that the man is a secreter is also specifically called out as a bit of good luck since it allows them to identify his blood type through his saliva. The book was written in 1992, and actual DNA testing is not mentioned, but given how new the technology was at the time and the series being set in Vermont using an ABO system was much faster.
* ''Literature/{{Twilight}}'': In ''Breaking Dawn'' the Cullens keep a refrigerator full of blood in their house. Naturally it's the very rare O-.

[[folder:Live Action TV]]
* Nyko of ''Series/{{The 100}}'' has Rh-null blood, one of the rarest blood types in the world. This proves a problem when they can't find a match for him when he's dying from a wound.
* Comes up ''twice'' on ''Series/TheATeam''. The first time, B.A. needs a blood transfusion, type ABNegative. The only other member of the team with this blood type is Murdock. The second time, Murdock needs a transfusion. Guess.
* Rare blood types always uncover parentage secrets on soap operas. ''Series/AllMyChildren'' used it a few years ago to reveal that Jack was Greenlee's father, though the rare blood type was never named. Much worse, ''Series/OneLifeToLive'' back in the 80s had Tina find her lost son because they both had [[ArtisticLicenseBiology Blood Type G]].
** ''All My Children'' even inverted this--when Dimitri learned that his presumed daughter Madeline was O-, he realized that she couldn't be his daughter because her ''common'' blood type was not possible, given his rare one.
* (Sort of) averted on ''Series/{{Angel}}'', where when a vampire has refrigerated blood on hand, it is usually "O-neg".
* In "Anslo Garrick" (Part 1) of ''Series/TheBlacklist'', it is revealed that both Red and Ressler share the same blood type (B-), which came in handy since Red needs to give Ressler an immediate blood transfusion to help him recover after having been shot in the leg.
* On ''Series/{{Charmed}}'', Piper has AB negative blood as does Andy. This is shown in the episode "The Wendigo". The Wendigo also attacks people with the AB negative blood type.
-->'''Piper:''' Yeah, I'm fine. If I pass out and I need a transfusion, I'm AB negative. It's very rare. It could be a problem.\\
'''Andy:''' Uh, I was just thinking how I'm probably not the best cop to be on this stakeout with, seeing as how I'm, uh, AB negative.\\
'''Andy:''' Maybe. I've just gone over the coroners reports from Chicago, New Orleans, and now local. It turns out all the victims were AB negative.
* A third season episode of ''Series/{{Chuck}}'' features Casey [[spoiler:having to donate his AB- blood to save the life of a man he'd been trying to kill off and on for years (well, Chuck 'stole' it, but whatever)]].
* In a variant on ''Series/{{CSI}}'', a power outage shuts down the lab's equipment, and the investigators must resort to old-school ABO typing of blood evidence. Greg remarks that he's got clumping in his Type O sample; this is an error, as Type O is distinguished as such by its ''failure'' to clump when exposed to anti-A or anti-B serum. (It could've been O-positive and clumped in anti-Rh serum, but Rh-typing wasn't otherwise mentioned.)
* One episode of ''Series/DadsArmy'' was based around Pike being called up to join the regular army. The platoon can't get him out of it, so they hold a fish and chip supper to say goodbye to him - after which Pike announces that he was excused from joining the army because he has a very rare blood type, but didn't want to tell anyone until after the fish and chips.
* On ''Series/DarkAngel'', Max, all of the other X5s, and most likely other transgenics as well, are specifically genetically programmed to have O- blood, so they could swap blood (and organs) on the battlefield. Also, the show makes the goof of a blood transfusion for Logan being difficult to find because he's AB-. Fortunately, universal donor Max was handy.
* In ''Series/DeGrassi'', Holly J. only learns that she is adopted after discovering that she is type B, while both her parents are AB. She says--incorrectly--that children tend to have the same blood type as their parents, and Revelations Ensue. In fact there is absolutely nothing unlikely about two AB parents having a B child. Even if the script had been reversed--an AB child with B parents--it might only have implied that her ''father'' wasn’t who she thought.
* In ''Series/DesperateHousewives'', one of the characters began to suspect that another was their father because they both had AB- blood. Never mind that blood types don't actually work like this in real life (it's something to do with which factors you have and how they add together, he was far more likely to be A or B, and then positive simply because more people are positive and the positive genes are dominant, which is also why Rhesus negative women are more likely to have birth complications). It's also how [[spoiler: Gabrielle ultimately learns that Juanita was SwitchedAtBirth, which Carlos had tried to keep a secret from her]].
* The title character of ''Series/{{Dexter}}'' has a AB- as his bloodtype. It's shown in flashback that [[spoiler: Dexter's foster father contacted Dexter's biological father when Dexter was injured and needed a blood transfusion, which falls into the ArtisticLicenseBiology trope since in reality Dexter could have had ''any'' negative blood type given to him and been fine]].
* ''Series/DueSouth'' [[InvertedTrope inverts it]] in one episode, when an over-eager FBI agent excitedly declares that they now know the suspect's blood type. Fraser points out that the suspect's blood type is shared by a significant portion of the population of Chicago.
* In the ''Series/EverDecreasingCircles'' episode "A Strange Woman", Paul (Peter Egan) is taken away in a police car in the middle of the night. The following day, he explains that he is a registered blood donor and has a rare (yet unspecified) blood type and had to be rushed to the hospital to donate to an accident victim. His neighbour and self-perceived rival Martin (Richard Briers) promptly registers as a blood donor, and is disappointed to learn that he has Type O blood.
* ''Series/{{The Flash|2014}}'' plays with this in the episode Trajectory. Jesse needs an emergency blood transfusion but she has the blood type PZ-negative. Justified as she is not from this earth, she's from a different dimension, Earth-2. Luckily her father is a match.
* In ''Series/ForeverKnight'', they actually not only [[ShownTheirWork get the blood type info right]], saying Schanke, who is AB+ , "can take anything but motor oil," while O- can only receive O-, it's involved in a plot point, too. [[spoiler:The killer's mother had died from hepatitis contracted from a blood transfusion, which slipped through the screening process; he was taking out only O- donors who could have been the source]].
* ''Series/GoodTimes'' featured a rare blood type, U-, to facilitate a WhosOnFirst joke: "I have a very rare blood type, U Negative." "You positive?" "No, U Negative." And so forth.
* ''Series/GossipGirl'': Dan and Rufus Humphrey are both AB+. [[spoiler:Georgina's and Dan's "son" Milo is 0-]].
** In season five it turns out Chuck Bass has a super duper rare blood type (never specified which one) that means the only people in the whole wide world who could possibly give him blood are blood relatives. [[spoiler:Which is how he ends up finding out his father is not quite as dead as we thought he was]].
* The ''Series/HancocksHalfHour'' episode "The Blood Donor" is an iconic piece of British comedy. The Hancock character is nervous about giving blood at first but changes his mind when he discovers that his blood is AB- (although at one point the doctor tells him he is rhesus ''positive'', causing him to remark "Rhesus? They're monkeys, aren't they?"). This is really TruthInTelevision given that the Rh factor is indeed named after the Rhesus monkey in which it was first discovered. On returning home he pesters the hospital to make sure his blood is given to "the right sort of person", but then [[spoiler:he injures himself, is rushed back to hospital and is given a transfusion of the blood he has just donated. HereWeGoAgain]].
* ''Series/{{House}}'' both lampshades the first and subverts the second. The subversion is something we expect from a medical show, while the lampshading comes later as House solves a case based on a patient's blood type (and a conversation with Wilson): the patient had blood type A, but when he was given a blood transfusion, was given the wrong type. Nobody ever thought to ASK him what his blood type even was to begin with. Then again, the fact that doctors do not ask patients their blood type is TruthInTelevision. ([[spoiler:In the episode, the patient's Lupus caused a blood test to give the wrong result]].) Many people don't know, some think they know but are wrong, and very very few people know that more than the ABO/Rh factors even exist, much less what they have. And that's assuming the patient is conscious and coherent.
** In another episode, they play the trope straight. A woman in need of a liver transplant is apparently disadvantaged by having AB- blood. In fact, blood type would be the least of her worries.
* This is how Tommy discovers [[spoiler:that he's adopted]] in ''Series/HeroesReborn''. [[spoiler:He's AB while his mother Anne is O negative, making their relationship biologically impossible. Anne has wanted to tell him about his true parentage, but doesn't out of fear that Tommy would be captured because Tommy is an evolved human]].
* BSM Williams in ''Series/ItAintHalfHotMum'' has Type AB blood. In the episode "It's a Wise Child", this provides the Concert Party with evidence that, contrary to what Williams suspects, he is not Gunner Parkins' father, as Parkins has Type O blood.
* ''Series/{{iZombie}}'' has a slightly justified example in the first season finale when [[spoiler: Evan is caught in an explosion at Meat Cute]]. He has O Negative blood, which can only receive itself in transfusions, and the hospital is in short supply (TruthInTelevision, as O Negative is the universal donor and is used quite often). Since he needs a transfusion immediately, the only option available at the moment is [[spoiler: his sister, Liv. She refuses, however, because she's also a zombie and doesn't want to infect him]].
* Another blend of this with CriticalResearchFailure appeared on ''Series/{{Law and Order SVU}}'', when a comatose woman's mysterious pregnancy is under investigation. Her blood type is A and the fetus's is AB, so the investigators conclude that its father ''must'' be type B ... even though a type AB father would also have a 50/50 chance of passing the B trait on to his child. Particularly deserving of a YouFailGeneticsForever is Huang, who agrees that the father's type must be B despite his own medical training.
** And again on ''SVU'', they assert that two type A parents must have a type A child. In real life, there is a chance they could have a type O child. This includes dismissing the possibility the mother had an affair because, they say, there's no way a Type A mother could have a Type B child, regardless of the father's blood type -- also completely untrue.
* ''Series/{{Lost}}'' features a scene in which Jack struggles to find a universal O- donor (needed in emergencies when a blood type cannot be determined) for Boone. Failing to find a match among the other survivors, reveals himself to be O+ (which could put Boone into shock if he is not an O type himself) and performs the transfusion using his own blood. He actually got Hurley to ask nearly everyone in the camp their blood type but only 4 people knew.
** Season 5 reveals that Kate is actually universal donor.
* In ''Series/MajorCrimes'', during their investigation, the team discovers that the father that was missing had AB type blood, [[spoiler: which means he couldn't have fathered his type O daughter]].
* The ''Series/{{MASH}}'' episode "Life Time", where Hawkeye and company are racing against the clock to save a soldier who of course has AB-, luckily Winchester has "that elusive type."
** Normally averted on the show: All sorts of blood-types show up and they routinely run short of all of them.
** The writers adapted the trope to make its use accurate and believable for the time period. It's never said that the soldier can only take AB- blood; it's stated (by Potter) that AB- blood would be the best for him. In the 50s it was thought that the more blood the patient had lost, the more important it was to provide the exact blood type.
** They also had an episode about this. One wounded racist marine has a rare blood type and they tell him the only source is from a black soldier. They start applying makeup to make him darker and darker until he believes he's turning black. After they tell him he learns some tolerance.
*** Which seems to be based on "Archie Gives Blood", a season one episode of ''Series/AllInTheFamily'' where Archie donates blood, and is concerned the recipient will not be Caucasian, because [[ArtisticLicenseBiology he believes blood can only be given to a recipient of the same race as the donor]].
** In another episode a soldier is given the wrong blood and has a severe reaction. They gave the blood type listed on his dog tags - but they weren't his tags. He [[DeadPersonImpersonation stole them from a buddy who was killed]] in the attack he was wounded in, because the buddy [[{{Retirony}} was going to be sent home]].
** Another common order given for patients who don't need to go into surgery ''right this damn second or they're going to die'' is "type and cross-match" so many units of blood. This directly tests the recipient's serum against the donor's blood cells, to verify that the recipient won't have any transfusion reaction from secondary antigens due to antibodies that might be present in his blood.
** [[Recap/MashS1E11GermWarfare An early episode]] has a North Korean patient with a rare blood type needing a transfusion, and the only one in the entire camp with the same blood type is Frank. When the patient shows signs of hepatitis, HilarityEnsues when Hawk and Trapper must keep him away from Hot Lips until his test results are in.
** The episode "Your Hit Parade" in Season 6 features an AB- patient during a period of heavy casualties. Hawkeye asks for 4 units during surgery, Klinger informs they only had 2 to start with and both were used during the first batch of wounded. They mention collecting the patients blood during surgery to filter and give back to him, then spend the rest of the episode trying to find more. The unavailability of any donors is partly justified by the heavy casualties and the other medical units being forced to bug out, but it is implied there are only 2 other people available to donate in Asia with the correct blood type.
* The season-two finale of ''Series/{{Monk}}'' featured a victim whose blood group was "AB-negative with a D- antigen--the rarest blood-type in the world!" It is indeed rare; in fact, [[ArtisticLicenseBiology it doesn't exist]]. [[note]]Although it is possible for certain blood subtypes to show up this way on a test, the one doing the testing should have recognized an impossible result and retested.[[/note]] This turned out to be why he was murdered -- he was a death row inmate about to be executed, with his blood going to a local philanthropist in need of an operation. A prison employee had a grudge against the philanthropist and couldn't let that happen, so they poisoned the prisoner's last meal, making the blood worthless.
* On ''Series/{{Moonlight}}'', Beth Turner has "AO-" blood, which is especially tasty to vampires. While technically a real blood group, AO is just a rather pedantic way of giving one of the two genetic possibilities for type A blood.
* ''Series/NeverTheTwain'': Oliver tries to get out of donating blood to his rival Simon by claiming his blood type is 'Z'. (He's...not a doctor.)
* ''Series/{{Oz}}''. When a prison guard is stabbed in the eyes and needs a blood transfusion, the only donor immediately available is inmate Ryan O'Reilly, who makes it a condition of his helping that his mentally-ill brother be moved into Em City with him.
* In ''Series/PersonOfInterest'', Shaw is AB+, which allows her to accept blood from anyone. She takes advantage of this in one episode after being wounded by taking a Russian mobster prisoner and stealing his blood for a transfusion.
* ''Series/{{Preacher}}'': Tulip has AB- blood. No surprisingly, Cassidy does not have a blood pack from among his dozen or so that matches. Apparently having little to no medical knowledge, neither he nor Jesse consider the option of using A-, B- or O-.
* ''Series/ThePretender'': Jarod and Kyle both had AB- blood, along with a young boy from one episode who was in dire need of a heart transplant. Guess where that went.
* ''Series/{{Psych}}'' actually did the research in an episode. When a man needed O negative donations, Lassiter had the needed blood type. But it's also played straight when Lassiter's O-neg blood is referred to as such a rare blood type that donors are extremely difficult to find.
* In the last season of ''Series/QueerAsFolk'', after the bombing in Babylon, Michael has been seriously hurt and taken to the hospital. The ER doctor says he needs a blood tranfusion, but he's AB negative and they are short on his type. Brian answers he's O negative, universal donor and wants them to take his blood. But they won't take it because he's gay and they are considered too high of a risk for HIV. Brian then goes berserk, but Ben tells him he couln't give his blood anyway because he had cancer. This is a reference to the [[http://gaylife.about.com/od/stdsgeneralhealth/a/blooddonation.htm Ban On Blood Donations From Gay Men]] in the USA implemented in 1985, and despite what the show says the policy isn't as set-in-stone as many media outlets make it seem. Doctors at hospitals are desperate for any compatible blood type in a pinch, and in real life they more than likely wouldn't turn Brian away if he were on the scene. It's only at blood drives that they screen for gay men. It was all just a convenient excuse for an {{Anvilicious}}ly [[RuleOfDrama dramatic]] take on a real gay issue.
* In ''Series/StarTrekTheOriginalSeries'' episode "Journey to Babel", Ambassador Sarek requires open heart surgery which is hampered by his T- blood, noted as being rare, even for a Vulcan. Luckily, another person on board also had T- blood -- Sarek's son, Spock, and that had to be filtered because of Spocks [[HalfHumanHybrid human heritage]].
** And since Vulcans have copper-based rather than Humans' iron-based blood, it's realistic that it would use a different blood type system.
* In ''Series/{{Supernatural}}'' it was claimed that a man with AB blood had a son who was O-.
* Bay in ''SwitchedAtBirth'' has AB blood, though she doesn't mention her Rh factor. This is a clue to her parentage, since both her parents are type A. (Type AB requires inheriting an A from one parent and a B from the other. A child of two type As can only be type A or type O.)
* In ''Series/TerminatorTheSarahConnorChronicles'', they mentioned that Sarah had O- blood but John had AB- blood; this would mean that she couldn't possibly be his mother, barring vanishingly rare situations like mutation or [[http://en.wikipedia.org/wiki/Hh_antigen_system Bombay blood type]][[note]] For the record, type O is recessive, and Sarah is therefore by necessity homozygous for O. Johny could be AO (type A) or BO (type B), but type AB is not possible[[/note]]. Sarah being unable to give blood to the AB- Derek Reese despite being a universal donor is correct due to compatibility for plasma being reversed compared to blood cells -- someone with type O is the least useful donor because their plasma could contain antibodies against non-O blood types.
* ''Series/TrueBlood''. The (sorta) title drink has each blood type as a separate flavor, and vampires have preferences on their favorite. Newbie vamp Jessica drinks a cocktail of several different types to get used to the taste.
** Vampires on the show also express preference for different "flavors" of real blood; Jessica orders room service in a hotel and a young man at the door introduces himself as "male, straight, B positive." Later, Erik offers another vampire "a human, AB negative, very rare."
* ''Series/TwinPeaks'': In the first episode of the second season, the blood of the killer [[spoiler:later revealed to be Leland]] is said to be "a rare type, AB Negative".
* In ''Series/{{Victorious}}'', Robbie is about to have a surgery, but needs O- blood. Tori is the only one of their friends who has this blood type, but is about to star in a play. After Tori donates a pint of blood, the doctors end up losing it, and after donating another pint, Robbie ends up dropping it on the floor, forcing her to donate a third pint. Tori then becomes weak and disoriented during the play.
* In the present day scene at the end of one episode of ''Series/YoungIndianaJones'' (which took place in a hospital waiting room), a doctor comes out and asks if anyone present has a certain blood type, as they're running low and there's a kid with that blood type who needs immediate surgery. The person who Indy had been telling part of his life story to over the course of the episode volunteers to donate.

* The song "0 rhesus negativ" by German singer Udo Lindenberg involves the singer meeting a vampire, but being spared because the vampire can't stand that blood type.

* In the middle school musical ''{{Dracula}}, Baby'' Dracula offers to do anything in his power to help Lucy. He is asked if he's type B (Lucy's type) or O - the universal donor. He replies that he's type AB - the universal receiver.

[[folder:Video Games]]
* In ''VideoGame/DeadIsland'' all four of the virus-immune survivors have O negative blood. This is presumably not a coincidence, although it is never really explored.
* Toko in ''VisualNovel/KaraNoShoujo'' is of the Bombay blood group [[spoiler:which means that she can't get a blood transfusion after getting hit by a truck]].
* ''VideoGame/PersonaQShadowOfTheLabyrinth'' reveals Rise Kujikawa has type AB blood. The inverse side of this trope is also Lampshaded, as the groups note the strangeness of neither the Persona 3 or 4 case having any girl with type A blood, the most common type in Japan.
* Both Futaba Sakura and Goro Akechi in ''VideoGame/Persona5'' are AB-, which is especially notable as RH- is so rare in Japan that most works don't even list positive/negative distinction in blood types. It's very fitting for Futaba, as her Persona is a UFO (based on the works of Creator/HPLovecraft at that) and she's a very eccentric {{Hikikomori}}. For Akechi, [[spoiler:it may be an allusion to how he was born and raised as [[BastardAngst an outcast]] due to his parentage.]]
* In ''VideoGame/ResidentEvil6'' Albert Wesker and by extension his son Jake possess a rare blood type that grants immunity to TheVirus. Jake is willing to share his blood to save the world... for a price.
* ''VideoGame/ShadowHeartsCovenant'' has a door in one dungeon that will only open if a person with AB blood tries to open it; this was done by its builder to ensure her apprentice, the party member Lucia, wouldn't get into things she shouldn't. Only one member of your party can open it, leading to a brief puzzle to determine which of your party members is AB. Oddly enough, it isn't Yuri (type A) or Karin (also type A), the main characters -- it's [[spoiler:Gepetto. Joachim is type O and Lucia is type B]].
* In ''VideoGame/{{Yakuza}}'' 4, [[spoiler: Lily's rare blood type is the reason why when she suffered kidney failure, Saejima located her biological father and did whatever it took for him to donate one of his to her]].

[[folder: Webcomics]]
* In ''Webcomic/DarthsAndDroids'', Qui-Gon's player has his character's blood type written on his character sheet. It's O- making him a universal donor, however he ''actually'' wanted AB+ to make the character more capable of receiving medical treatment, but didn't know that there was a difference, and the type he picked would only be useful if he just needed blood plasma. Pete brings up that a universal recipient would be preferable, but he's also the {{Munchkin}} of the group.
* Feral from ''Webcomic/StrongFemaleProtagonist'' takes the universal donor version of this trope UpToEleven with her organs and tissue being a perfect match for anyone who gets them grafted in. In addition her HealingFactor means that 8-10 fully functional healthy hearts, over 30 livers and kidneys, etc. can be removed from her per day; with the hardest part being keeping her body cavity from healing shut long enough to extract said organs. Well, that and her [[StrappedToAnOperatingTable immunity to painkillers and anethesia]]....

[[folder:Western Animation]]
* The plot of ''WesternAnimation/BatmanAndMisterFreezeSubZero'' involves Mr. Freeze kidnapping Barbara Gordon because she shares the AB- blood type with his wife. Barbara even brings up that he could use any negative blood for a blood transfusion, but it turns out that [[OrganTheft he needs more than just her blood]]. TruthInTelevision in that organ transplants are ideally done between people of the same blood type to reduce the risk of rejection, and Mr. Freeze is obsessive enough over getting his wife back that he'd try to be as exact as possible.
* An episode of ''WesternAnimation/CourageTheCowardlyDog'' has a government agency capture [[DamselInDistress Muriel]] to [[PokeThePoodle forcefully grow her hair out and then shave it to make wigs]], because she was one of the three or so people on the planet (who they hadn't already captured) with the blood type "ABXYZ."
* In ''WesternAnimation/HighlanderTheAnimatedSeries'', it is mentioned in one episode that all Immortals are universal blood donors (O-). This is used in that episode as an explanation as to why Quentin's blood can save a wounded mortal's life, then never gets mentioned again.
* ''WesternAnimation/KingOfTheHill'' sees Peggy bragging to neighbour Minh about how she has blood of type AB- and giving this trope its name.
-->'''Mihn:''' I'm type O. Universal donor.\\
'''Peggy:''' Oh, yeah? Well I have the rarest blood of all; AB Negative! Liquid Gold!
* ''WesternAnimation/TheSimpsons'' second season episode "Blood Feud," Mr. Burns needs a OO- (double-O negative) transplant, and Bart is the only person in town with the same blood type. He uses it as a bargaining chip.
** Homer is also stated as being "N negative", [[http://en.wikipedia.org/wiki/MNS_antigen_system which does exist]].
* In ''WesternAnimation/SouthPark'', it is revealed that Kyle and Cartman are the only two people in town with AB- blood... leading to some problems when Kyle needs a kidney transplant and Cartman won't let him have it.
* In the ''WesternAnimation/SuperFriends'' episode "A Pint of Life", a young boy is injured in an accident. He needs a transfusion, but his blood type is so rare that the only possible donor they can think of is his father. Since his father is currently exploring the Amazon Rainforest, the Super Friends have to retrieve him.
* In the ''WesternAnimation/YoungJustice'' episode "Image", a young boy named Garfield Logan is caught in an explosion and is badly injured. Dying from his injuries, he needed a transfusion of type O blood to live, of which the isolated farm's supplies were just destroyed. Nobody on site has type O blood, except [[spoiler: Miss Martian, who can shapeshift her body to the cellular level. The [[SuperhumanTransfusion transfusion]] will later give the character shapeshifting powers and he reappears in season 2 as Beast Boy.]]

[[folder:Real Life]]
* [[http://en.wikipedia.org/wiki/Hh_antigen_system Bombay Type blood]] is an extremely rare blood type that cannot accept any ABO-normal blood. Genetically they may have any of the normal ABO types, but they test as type O due to a lack of H antigen, which is present in ABO-normal people (type O only has H; in A, B and AB the H acts as an anchor for the additional antigens). They will have a hemolytic reaction if given O negative (which is otherwise considered the universal donor for blood) and must be given Bombay (Oh) blood. For this reason when a blood bank receives a Bombay donation, they never discard it as they do with other blood types after a certain period or expiration date. It's named after the city in which it was discovered, and people who have it are mostly concentrated in that region of India (even there, they're a minority), and practically nowhere else in the world.
* Patients with active systemic lupus erythematosus ([=SLE=]) sometimes become intolerant of their own ABO/Rh blood type, as their overly-picky immune systems launch attacks against even their own blood cells. A perfect cross-match is essential before such patients receive a transfusion, and the blood itself must be infused slowly and at body temperature to minimize any risk of reaction.
* In Japan, one's blood type is considered important. Having AB- blood apparently marks one out as, essentially, a ByronicHero (destined for leadership, intelligent, magnetic personality ''but'' prone to arrogance and poor self-control). Given that UsefulNotes/JohnFKennedy and Creator/MarilynMonroe were AB-, perhaps they are on to something.
* The Rh-null phenotype comes around when a person has no Rh antigens in their bloodstream. [[note]]The term "Rh-negative" refers to the lack of Rh antigen D, the most clinically significant; Rh-null means 99% or more of the known Rh antigens are not present. [[/note]] Because of this, people who hold this blood type are the universal donors for the Rh system, but can only receive blood from other Rh-null people -- something that may prove difficult because it's ''extremely'' rare. First reported in 1961, there are currently [[http://www.theatlantic.com/health/archive/2014/10/the-most-precious-blood-on-earth/381911/ less than 50]] known people with this blood type around the world.
* Scientists are continually discovering new blood group antigens so rare that they may only be present in ''one family'' (or so common that they're only ''absent'' in one family). Typically, these antigens are only discovered when a daughter or daughter-in-law of one of said families finds herself unable to carry a child to term, and the doctors pin the cause on [[https://en.wikipedia.org/wiki/Hemolytic_disease_of_the_newborn HDFN]] caused by an antibody no one has ever seen before, that reacts to either nothing but a family member's blood or everything but a family member's blood[[note]]If possible, if the antigen in question is a variant of a known antigen, genetic testing will also be done to confirm that this is a completely new variant[[/note]]. In the case of families missing an antigen that basically everyone else on Earth possesses, a family member who develops an antibody to said antigen will literally only be able to receive blood from a close relative.