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{{Mad Scientist}}s in WesternAnimation.
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* ''WesternAnimation/OneHundredAndOneDalmatiansTheSeries'': P.H. De Vil, Cruella's cousin who she often collaborates with to carry out some of her schemes. He's usually inventing some kind of device to accomplish some evil deed, such as an earthquake machine, a personality splitter, and a robotic version of Rolly. He is also willing to test dangerous chemicals on animals without any consideration of the harm he may be doing to them.
* ''WesternAnimation/AdventureTime'':
** [[Characters/AdventureTimePrincessBubblegum Princess Bubblegum]] is the sweet, benevolent ruler of the Candy Kingdom, but is also a highly intelligent scientist. Although normally level-headed and peace-loving, she has accidentally unleashed a zombie plague twice, created a number of artificial life-forms (including all the citizens of the Candy Kingdom, a giant immortal candy sphinx named Goliad who almost destroyed the kingdom, and the tyrannical, emotionally-unstable Earl of Lemongrab), has skeletons chained to her walls, created a potion that can permanently paralyze someone, killed a jellyfish to make a sandwich, tried to have the Duke of Nuts imprisoned on spurious charges just because she was mad about him compulsively eating her pudding stash, and was prepared to torture the Ice King in order to get a cure for the outbreak of "freezer-burn flu" he accidentally unleashed. Her "For SCIENCE!" attitude, and her devotion to protecting her kingdom, cause... interesting things to happen.
** Assuming that he was the one who designed and built the [[ElectricTorture Reconditioning Chamber]] and the [[CoolSword Sound Sword]], then [[TheMentallyDisturbed Lemongrab]] definitely qualifies.
** "Preboot" introduces Dr. Gross, a refugee from [[spoiler: the last surviving colony of humans on Earth]] who combines an obsession with [[TranshumanTreachery creating mutant cross-bred animals and cyborgs]] with [[UnwillingRoboticisation a rather lax attitude towards getting consent from her test subjects]].
%%* ''WesternAnimation/AlphaTeensOnMachines'': Recombo.%%Quotes aren't context.
%%-->'''Recombo:''' My colleagues laughed and called me Recombo. They said it couldn't be done. But I shall prove them all wrong. Back home, people called me mad.\\
%%'''King:''' Mad? I was thinking more "total wacko"!
* ''WesternAnimation/TheAlvinShow'' has Clyde Crashcup, who tries (but always fails) to "invent" something.
* Dr. Weird from ''WesternAnimation/AquaTeenHungerForce''.
-->'''Dr. Weird:''' Gentlemen! I have created... this thing.\\
'''Steve:''' What is it?\\
'''Dr. Weird:''' I don't know! Stand over here.\\
'''Steve:''' What, over here -- hey!\\
'''Dr. Weird:''' It works! [[TheMadHatter I am one can short of a six-pack!]] ''(EvilLaugh)''
* ''WesternAnimation/{{Arcane}}'':
** Singed is a chemist and biologist who assisted crime lord Silco in creating shimmer, a drug that enhances its users' strengths and durability while turning them into violent hulking beings.
** [[MadBomber Jinx]] is an engineer who uses scraps she could find to build her weapons and recreate Jayce's first Hextech experiment.
* ''WesternAnimation/{{Archer}}'': Doctor Krieger. Some of his creations include "Fister Roboto", a fully intergrated [[{{Sexbot}} multi-fetish artificial being]], and an [[NuclearMutant irradiated]] pig named Pigley III who eats people. He was also responsible for [[WeCanRebuildHim rebuilding]] Russian agent Katya Kazanova into a {{Cyborg}} and built Ray Gillette his [[ArtificialLimbs robot arm]].
* Dr. Gangrene in ''WesternAnimation/AttackOfTheKillerTomatoes'', the creator of the eponymous Killer Tomatoes. Defied by the man himself however,
-->'''Dr. Gangrene:''' I'm not a mad scientist, ''[[InsistentTerminology I'm an angry scientist!]]''
* The Dark Knight always seems to be neck-deep in mad scientists in ''WesternAnimation/BatmanTheAnimatedSeries''. Within the first five episodes of the show, he runs afoul of [[Recap/BatmanTheAnimatedSeriesE1OnLeatherWings Man-Bat]], [[Recap/BatmanTheAnimatedSeriesE3NothingToFear the Scarecrow]], and [[Recap/BatmanTheAnimatedSeriesE5PrettyPoison Poison Ivy]], scientists-turned-supercriminals all. Scarecrow actually goes the whole hog with the trope, as his initial appearance features a plot to ruin the university he was fired from and murder all those who [[TheyCalledMeMad called his sanity into question]]... which should answer the question of his sanity quite comprehensively.
* WesternAnimation/TheBeatles have come across a couple of mad scientists. Professor Psycho (from "Baby's In Black") brings a vampire girl to life and tries to get her married to Paul, while Dr. Dora Florahyde ("If I Fell") wants to transfer John's thoughts into her FrankensteinsMonster to bring it to life. (This was unintended as the doc told TheIgor to get the brains of a beetle. Igor responded that John is "the brains of the Beatles.")
* ''WesternAnimation/Ben10'' has Doctor Animo, the very much insane scientist whose goal is to mutate the entire population of the Earth, humans and animals alike, into monstrosities as one of Ben's most persistent enemies.
* ''WesternAnimation/BikerMiceFromMars'':
** The original 1993 series has Dr. Karbunkle, who often creates inventions for Limburger and his minions to use against the Biker Mice and also experimented on the Biker Mice, which resulted in Modo getting an eye-patch and a robotic arm and Throttle being blinded and needing special sunglasses to see.
** The 2006 SequelSeries has Dr. Catorkian, a Catatonian scientist who creates inventions to help the Catatonians and Ronaldo Rump defeat the Biker Mice.
* ''WesternAnimation/CaptainPlanetAndThePlaneteers'': Dr. Barbara "Babs" Blight is an insane, yet brilliant scientist, and represents unethical scientific research and technology in the wrong hands. Sometimes, though, she simply causes environmental damage [[ForTheEvulz for the sake of doing so]]. Some of her plans have a FreudianExcuse related to her [[GoodScarsEvilScars facial scar]], which can actually make her UnintentionallySympathetic to some viewers. It's a pity that [[MotherNature Gaia]], the only character in the show who ''has'' healing powers, is the one Blight would ''never'' be willing to ask for help. Instead, she has tried to kill or at least harm the Spirit of Earth quite a few times.
* ''WesternAnimation/ChipNDaleRescueRangers'': Professor Norton Nimnul, who frequently creates inventions to cause trouble that the Rescue Rangers have to stop.
* ''WesternAnimation/ClassicDisneyShorts'':
** Dr. Frankenollie in ''WesternAnimation/RunawayBrain'' creates a FrankensteinMonster resembling Pete named Julius and invites Mickey Mouse over so he can have his creation and the hapless rodent switch brains.
** A much earlier example is Dr. XXX, the title character of the 1933 short ''WesternAnimation/TheMadDoctor'', who kidnaps Mickey's dog Pluto with the intent of putting the dog's head on the body of a chicken.
* ''WesternAnimation/CloneHigh'': Dr. Cinnamon J. Scudworth certainly qualifies. While his day job is principal of the eponymous school, he's also the scientist who created all the clones of historical figures attending Clone High. He's also certainly got the "mad" part down, being generally characterized as a wacky CloudCuckoolander.
* ''WesternAnimation/CodeLyoko'': Franz Hopper is less "mad" than he is "slightly unhinged". Still, though, he manages to create a computer program that can venture into the world, [[GrandTheftMe take people hostage]], create poisonous gas, create blizzards, and many many other things, so he definitely counts.
* ''WesternAnimation/CodenameKidsNextDoor'' has a couple, including Chester and Professor XXX-L.
* ''WesternAnimation/CourageTheCowardlyDog'' has Di Lung, a scheming GadgeteerGenius who often causes trouble for Courage and his owners with his unusual inventions.
* ''WesternAnimation/COPS1988'': Dr. Badvibes is the GadgeteerGenius of Big Boss' criminal organization.
* ''WesternAnimation/DarkwingDuck'':
** Megavolt is deranged and frequently has plans that involve using his inventions to manipulate electronic appliances.
** Bushroot is a botanist who mutated himself into a duck/plant hybrid.
* ''WesternAnimation/DextersLaboratory'':
** The main character Dexter is a kid scientist and isn't above conducting unorthodox experiments.
** Dexter's rival Mandark is also a boy genius and is often shown to be less scrupulous than Dexter.
* ''WesternAnimation/TheDickTracyShow'' has the Brow and Oodles in possession of Dr. Von Stooker's notebook which has a formula to turn people invisible ("Lab Grab"). Joe Jitsu plants a phony book on the crooks, with the resulting mixtures they make turning into GargleBlaster stuff.
* ''WesternAnimation/{{Freakazoid}}'' has the title character's ArchNemesis [[MyBrainIsBig The Lobe]], as well as the guest villain Dr. Mystico (played by Creator/TimCurry!). Mystico is notable for being not only [[EvilIsHammy traditionally "mad"]], but also something of a CloudCuckooLander to boot.
-->'''Freakazoid:''' ''(Makes a "he's crazy" gesture with his finger)''\\
'''Dr. Mystico:''' I saw that!\\
'''Freakazoid:''' Saw what?\\
'''Dr. Mystico:''' That! ''(Copies the gesture)'' [[ComicallyMissingThePoint You think I've got a]] ''[[ComicallyMissingThePoint clock]]'' [[ComicallyMissingThePoint in my head,]] ''[[ComicallyMissingThePoint don't you!?]]''
* ''WesternAnimation/{{Futurama}}'': Professor Farnsworth takes this to the lengths of parody and beyond, casually creating doomsday devices, atomic supermen and hybrid lifeforms, experimenting on himself, and being several forks short of a silverware drawer.
** He builds {{Doomsday Device}}s a lot. Oh, he doesn't plan to use them, he just seems to think they're cool. "I suppose I could part with ''one'' and still be feared..."
** At one point the Planet Express crew were figuring how to enter New New York's Central Bureaucracy.
--->'''Prof. Farnsworth:''' You can't just waltz into the Central Bureaucracy! It's a tangled web of red tape and regulations. I've never been, but a friend of mine went completely mad trying to find the washroom there.\\
'''Leela:''' Then we'll need a guide, someone who's been there before.\\
'''Prof. Farnsworth:''' Oh, I've been there. Lots of times! ''[[[LaughingMad laughs maniacally]]]''
** One episode revealed that he spent twenty-five years in a mental institution starting when he was a teenager. His rival and former student, Professor [[BerserkButton WERNSTROM!]] is of the evil (or at least [[{{Jerkass}} asshole]]) variation.
** Creator/LeonardoDaVinci also counts.
* ''WesternAnimation/GarfieldAndFriends'': One builds the Incredibly Stupid Swamp Monster. [[ShoutOut How mad]] [[Series/TheTonightShow is he?]]" asks Roy. "He's so mad," replies Orson, "he spent ten years trying to cure his pet cat's measles before realizing it was a leopard."
* Nathan from ''WesternAnimation/TheGarfieldShow'' is a child mad scientist whose nefarious inventions have caused problems for Garfield on more than one occasion.
* ''WesternAnimation/{{Gargoyles}}'': Dr. Sevarius isn't quite mad so much as he is amoral, but he displays a touch of the theatricality that is the hallmark of the best nutty professors.
* ''WesternAnimation/GeneratorRex'': Cesar single-handedly invents weaponry that can take down an entire highly-trained government base, but is a CloudCuckooLander on a good day and a totally lacks any sense of practicality or ethics on a bad day.
* ''WesternAnimation/GIJoeARealAmericanHero'': Dr. Mindbender serves as Cobra's chief scientist, his most notable contribution being the creation of the terrorist organization's second leader [[ArtificialHuman Serpentor]].
* ''WesternAnimation/{{Grojband}}'' has Kin Kujira, TheSmartGuy and GadgeteerGenius of Grojband whose obsession with creating usually dangerous inventions (that often he tests on his friends) sometimes borders on making him a CreepyChild.
-->'''Kin:''' I think I can build something that can help us... '''or cause untold horrors'''! ''[EvilLaugh]''
* ''WesternAnimation/TheHead'': Not how the trope usually plays out, as he's a PunchClockVillain rather than a DiabolicalMastermind, but Dr. Elliot starts out as a {{Cloudcuckoolander}} and [[SanitySlippage just gets worse from there]], to the point that his mooks eventually mutiny against him.
* ''WesternAnimation/InsideJob2021'':
** VillainProtagonist Reagan Ridley is a GadgeteerGenius working as a team leader for an EvilInc run by TheIlluminati to help administrate their control over the free world. She's more on the AffablyEvil side of the spectrum, but her {{Cloudcuckoolander}} tendencies and [[NoSocialSkills lack of social skills]] have resulted in a mountain of HR complaints about actions such as terrorizing her coworkers with a {{mecha}} for forgetting to fill out their time cards.
** Reagan's cohort Dr. Andre Lee is a free-spirited MadDoctor and head of their biochemistry department. He's a FunctionalAddict who spends most of his time high on whatever he can get his hands on and doesn't concern himself with the ethical ramifications of things like implanting a subdermal ShockCollar in the President of the United States to make him a more effective PuppetKing.
** Reagan's father Rand was her predecessor at the company but was fired after he had a mental breakdown that resulted in him attempting to [[TheNightThatNeverEnds destroy the Sun]] (which he justifies by saying he was going to end skin cancer) and almost blowing their cover. Nowadays he's TheAlcoholic {{Cloudcuckoolander}} who spends his time finding [[TheGadfly creative ways to piss off his old boss]], such as turning Reagan's robotic replica of the President of the United States into a PresidentEvil or starting a Website/YouTube channel [[CassandraTruth exposing various conspiracies]] [[ConspiracyTheorist but acting crazy enough that nobody believes him so he's more of an inconvenience than an actual threat to the organization]].
* One episode of ''WesternAnimation/InspectorGadget'' features the [[FunWithAcronyms M.A.D.]] Scientist -- that is, a scientist who works for [[NebulousEvilOrganisation M.A.D.]] However, he gets [[BerserkButton really, really peeved when someone calls him a mad scientist]], screaming, "I'M NOT MAD!"
-->''"I'm not '''MAD!''' I'm '''Dr. Focus!''' ''[gets arrested]'' Now I'm '''really''' mad!"''
* ''WesternAnimation/InvaderZim'':
** [[Characters/InvaderZimZim The title character]] is a mad scientist himself. In fact, in a script for an incomplete StartOfDarkness episode about him, Zim was actually a military scientist for his race whose creation, an "Infinite Absorbing Blob" was responsible for killing two of his previous leaders.
** Dib and Professor Membrane are also Mad Scientists, albeit less on the evil side than Zim. Dib is perhaps Madder, since his inventions revolve around his all-consuming obsession to destroy ZIM, whereas his father's inventions are more geared toward helping humanity (even the Super Toast).
* ''WesternAnimation/{{Jellystone}}'': No sane doctor would even consider half of the things Cindy Bear comes up with. Her innovations do work the way they're intended to but the purposes she creates them for aren't exactly conventional or necessarily ethical. She complains in "Squish or Miss" about the ethics board prohibiting one of her experiments.
* ''WesternAnimation/JimmyTwoShoes'':
** Heloise. [[EnfantTerrible Despite appearing as a cute little girl, she is a sadistic evil genius]] who makes destructive inventions to spread misery, conducts torturous experiments on others, and likes to destroy things for fun.
** Heloise isn't the only one in Miseryville (the town even has an award ceremony just for them). One recurring character is Dr. Ludwig [[HisNameReallyIsBarkeep Von Scientist]], a German-accented evil genius of a demon who's got [[MyBrainIsBig more forehead than body]]. He's usually just the go-to "evil scientist" character when Heloise isn't available, but in "Heads Will Roll" he's shown to be Heloise's arch-rival and the only one who comes somewhat close to being as good of a mad scientist as her.
* ''WesternAnimation/JohnnyTest'''s older sisters Susan and Mary are both Mad Scientist teenagers. Also their friendly enemy, Eugene, a.k.a. "Bling Bling Boy".
* ''WesternAnimation/JonnyQuest'':
** Dr. Ashida in "Dragons of Ashida", who uses genetic engineering on lizards to increase their size and also has a [[LaughingMad maniacal laugh]].
** In "Terror Island", Dr. Chu Sing Ling uses a chemical to grow gigantic versions of normal creatures.
%%** Dr. Phorbus in "Peril of the Reptilian".
%%** Dr. Zin in general.
* The Ultra-Humanite from ''WesternAnimation/JusticeLeague'' has all the characteristics of the traditional, cultured MadScientist -- [[WickedCultured with an emphasis on 'cultured']].
-->'''Ultra-Humanite:''' ''[[[ItMakesSenseInContext giving an educational toy to a group of orphans]]]'' [[PetTheDog I welcome any opportunity to bring culture to the uncorrupted.]]
* ''WesternAnimation/{{Kaeloo}}'': Olaf, who is bent on trying to TakeOverTheWorld. He builds robots which he uses to attack people and doesn't think twice before kidnapping [[CosmicPlaything Stumpy]] and turning him into a cyborg [[UnwillingRoboticisation against his will]].
* ''WesternAnimation/KimPossible'': A fairly large share of the {{Recurring Character}}s, notably major antagonist [[HarmlessVillain Doctor Drakken]]. Even some of the good-guy characters (such as Kim's father and brothers) have mad-scientist tendencies.
%%* ''WesternAnimation/LeagueOfSuperEvil'''s Doktor Frogg.
* ''WesternAnimation/TheLegendOfKorra'': [[Characters/TheLegendOfKorraVarrickAndZhuLi Varrick]], although he's less cacklingly crazy and evil and more quirky and amoral.
%%* ''WesternAnimation/MakingFiends'': Vendetta creates tons of fiends, which also can be considered as forms of life.%%And?
%%* ''WesternAnimation/MegaBabies'': Nurse Lazlo.
* ''WesternAnimation/MiltonTheMonster'': Professor Weirdo and Count Kook create a monster with six drops of essence of terror and five drops of sinister sauce. Professor Weirdo means to add a tincture of tenderness so the creation would not turn on him, but Count Kook accidentally knocks in the entire beaker. The creation becomes the childlike Milton.
* ''WesternAnimation/MyLifeAsATeenageRobot'': Most of Tremorton’s citizens ''think'' that Nora Wakeman is this. While she is more saner then most of the examples listed, some of her inventions don’t seem to serve a true purpose.
* ''WesternAnimation/MyLittlePonyAndFriends'': The gizmonks, from "[[Recap/MyLittlePonyAndFriendsE15TheGreatRainbowCaper The Great Rainbow Caper]]", are obsessed with invention and experimentation for their own sake, gleefully cobbling together complex machines for no real reason or gain, and sometimes without even knowing what they're supposed to do.
* ''WesternAnimation/TheNewAdventuresOfSpeedRacer'':
** Dr. Norbius, a competitor of Pops Racer who sells his inventions to terrorists.
** Dr. Brainbiter traveled back in time to the Jurassic to acquire a rare mineral that would allow him to mind-control the human race.
* ''WesternAnimation/PhineasAndFerb'':
** [[Characters/PhineasAndFerbHeinzDoofenshmirtz Dr. Doofenshmirtz]] is an AffablyEvil PunchClockVillain trying to conquer the [[WhereTheHellIsSpringfield Tri-State Area]]. He insists on being called an ''evil'' scientist, considering "mad scientist" a slur. His alter ego from the 2nd dimension was one, but now serves as the dictator.
** Phineas and Ferb themselves, actually. They ''do'' build things like city-spanning roller coasters, time machines and space ships after all, and ''landscapes'' in their backyard. [[CheerfulChild Two of the sweetest, friendliest mad scientists you'll ever meet]], but still.
** With Phineastein, the Regurgitator, Professor Poofenplotz and all the members of L.O.V.E.M.U.F.F.I.N., it seems the show runs on this trope.
* The Brain of ''WesternAnimation/PinkyAndTheBrain'' always devises a scheme to take over the world, several of them involving machines and potions. He quite often pilots mechanical bodies to appear human and once tried to hypnotize everyone by feeding them pancakes laced with hypnotic fluid.
* ''WesternAnimation/PJMasks'': Romeo, a ChildProdigy with a knack for creating evil inventions and planning to take over the world.
* ''WesternAnimation/ThePowerpuffGirls1998'':
** Mojo Jojo sometimes tries to stop the girls using devices of his own invention and actually laughs maniacally several times. Also, he's a monkey.
** Professor Utonium, although he's far more benign than most. Every time he creates something useful (including the Girls themselves), it's by accident. But when he tries to do something ''intentionally'', it leads to a disaster.
* ''WesternAnimation/RandyCunninghamNinthGradeNinja'':
** [=McFist=]'s [[TheDragon Dragon]], Willem Viceroy III. To the point that he literally attended a college called "Mad Scientist University" (MSU for short) and was even valedictorian of his graduating class.
** Mrs. Driscoll's husband Jerry Driscoll, back when he was alive. In fact, he was in the same class as Viceroy at MSU and his primary rival for valedictorian. Viceroy got him arrested in order to take him out of the competition, and he died not long after. When he's briefly revived by Randy in "Dawn of the Driscoll", he tries to complete the "destroy the world" DoomsdayDevice he was building in college in order to become valedictorian of his class, completely unaware of how much time had passed since his death. He only gives up after he finds out the truth from Mrs. Driscoll. [[spoiler:And then claims it's time to get started on his "destroy the ''universe''" DoomsdayDevice. [[EveryoneHasStandards It's at this point Mrs. Driscoll requests Randy turn him back to normal]]]].
* [[Characters/RickAndMortyRickSanchez Rick Sanchez]] from ''WesternAnimation/RickAndMorty'' is as mad as they come, though he replaces the usual creepiness and cackle-happy lunacy with heaps and heaps of apathy for everything and everyone else (except maybe his grandchildren [[MoralityPet Morty]] and [[OnlySaneMan Summer]] and his daughter [[MadScientistsBeautifulDaughter Beth]]). He's someone who gives absolutely zero fucks about [[spoiler:leaving his entire dimension to die, and fleeing into another where his counterpart had died half a minute ago, burying him in the back yard and taking over his life]], and that makes him just as crazy as the cackling lunatic the trope usually conjures.
* ''WesternAnimation/RobotChicken'': [[NoNameGiven Whatever the scientist was]] who decided to resurrect a dead chicken in the title sequence for Seasons 1-5. The character in question is named [[MeaningfulName Dr. Fritz Huhnmörder]], though it isn't mentioned much ([[AllThereInTheManual not at all]]).
* ''Franchise/ScoobyDoo'':
** In the ''WesternAnimation/ScoobyDooWhereAreYou'' episode "[[Recap/ScoobyDooWhereAreYouS1E11AGaggleOfGallopingGhosts A Gaggle of Galloping Ghosts]]", Shaggy and Scooby play "mad scientist", whipping up a formula that would turn werewolves into pussycats. It is summarily rejected.
** Scooby himself becomes one in ''WesternAnimation/TheThirteenGhostsOfScoobyDoo'' episode "That's Monstertainment" when he and his pals are zapped into an old monster movie.
--->'''Scooby:''' Rive my reation rife!
** Velma Dinkley, the brains of the Scooby gang, becomes a mad scientist in the DVD feature ''WesternAnimation/ScoobyDooFrankencreepy'', but only because she's hypnotized.
* Parodied by ''WesternAnimation/SheepInTheBigCity'''s Angry Scientist (who becomes especially angry whenever anyone incorrectly refers to him as a mad scientist).
* ''WesternAnimation/TheSimpsons'': Professor Frink is a rather more amicable Mad Scientist, always apologetic when things go wrong with his inventions, and has a passion for inventing crazy things like self-aware robots that only scrub floors, auto-diallers with retractable wheels, automatic tap-dancing shoes, buildings that can sprout legs and run away from danger, and hamburger earmuffs.
-->'''Frink:''' ''[as a radio-controlled baby-plane with his son in it crashes]'' Oh, dear. My wife is going to kill me.
* ''WesternAnimation/SkysurferStrikeForce'' BigBad Cybron creates at least seven lethal cyborgs (and maybe his own daughter too, which would make eight), then wires an experimental computer brain into himself.
* ''WesternAnimation/SouthPark'':
** Dr. Mephesto, based on [[Film/TheIslandOfDrMoreau1996 Marlon Brando's Dr. Moreau]]. The guy's greatest experiment is a FIVE-ASSED MONKEY!
--->'''Chef:''' Hey, you're that crazy cracker from up on the hill.\\
'''Mephesto:''' Sir, if making mutant animals spliced with humans is crazy, then-! Uh. Hmm. Oh, never mind.
** UsefulNotes/SteveJobs conducts an experiment called the "[[Film/TheHumanCentipede HumancentiPad]]", in which he surgically connects three people together mouth-to-anus and constantly tortures them in the process. One of the victims is Kyle, [[WouldHurtAChild who is only in fourth grade]].
* ''WesternAnimation/TheSpectacularSpiderMan'''s Doctor Octopus is one of these.
* Dr. Bent, a.k.a. Overlord in ''WesternAnimation/SpiralZone'', a particulary nasty one for a kid's show as he created a horrible mist that causes "zones" that turn people into mindless zombies.
* In ''WesternAnimation/{{Spliced}}'', almost all of the characters are the creations of "some crazy doctor" based on [[Literature/TheIslandOfDoctorMoreau Dr. Moreau]], who was arrested prior to the series by authorities disgusted with the freaks of nature he created.
* [[Characters/SpongeBobSquarePantsSheldonPlankton Sheldon Plankton]] from ''WesternAnimation/SpongeBobSquarePants'' shows signs of being this.
* ''WesternAnimation/StarWarsTheCloneWars'':
** Dr. Nuvo Vindi was a former medical doctor who disappeared sometime around the Battle of Naboo before resurfacing in the employ of the Separatists. With their backing he decided to resurrect the [[ThePlague Blue Shadow Virus]], a plague that no known species is immune to and killed many people back in the day. Vindi went a step further to make it deadlier by converting it from a water-based strain to an airborne strain and having it delivered via bombs on key Republic worlds. After he's captured and his assistant droid sets off all the bombs in his hidden bunker, he's excited at the idea of one of the battle droids exiting the bunker and releasing the plague across Naboo.
** Not of the cacklingly crazy variety, the [[MegaCorp Techno Union]] has been shown to dabble in inhumane experiments on sentient beings in both this show and the now ''Legends'' [[WesternAnimation/StarWarsCloneWars microseries]]. In the Bad Batch arc in this series, [[CorruptCorporateExecutive Wat Tambor]] has the previously thought dead Clone Trooper [[spoiler: Echo]] plugged into a stasis tube to be used as an [[WetwareCPU organic computer]] against the army he fought for, while [[AndIMustScream reliving the moment of his "death" on loop for months]]. They also built the Organic Decimator, [[ExactlyWhatItSaysOnTheTin a small weapon that seeks out organic matter and vaporizes it]], which in the unfinished reels, Tambor casually tests on a captive native as a threat to intruders. In the latter series, they kidnap male Nelvaanians and mutate them into brainwashed, cyborg supersoldiers. While the latter series is not canon, the Techno Union's activities on Nelvaan have been re-canonized.
* The first of the ''WesternAnimation/SupermanTheatricalCartoons'', "WesternAnimation/TheMadScientist", has one as the villain, threatening to enact vengeance on all those who laughed at him with his electrothanasia-ray.
* Baxter Stockman from ''Franchise/TeenageMutantNinjaTurtles''.
* ''WesternAnimation/TheTick'':
** Chrome Dome and Brainchild.
** El Seed and the Breadmaster may also quality for developing formulae that make plants come to life and bread explode, respectively.
** "The Tick vs. Science" has an entire convention worth of mad scientists. To Chromedome's disgust, the attendants were all of the "weird but affable" variety.
---> '''Chromedome''': "Bah! Warm fuzzy nice nice! What good is science if no one gets hurt!?"
* ''WesternAnimation/TinyToonAdventures'' has Dr. [[PunnyName Gene Splicer]], the BigBad of the episode, "Hare Raising Night", who specializes in making MixAndMatchCritters, most notably Melvin the Monster. In addition, he is a boss in the Platform/SuperNintendo game, ''[[VideoGame/TinyToonAdventuresBusterBustsLoose Buster Busts Loose]]'', but in that game, he's only referred to as "the Mad Scientist". He is also the main villain (aside from Montana Max himself) in the Platform/SegaGenesis game, ''[[VideoGame/TinyToonAdventuresBustersHiddenTreasure Buster's Hidden Treasure]]'', which properly uses his full name.
* ''Franchise/{{Transformers}}'':
** ''WesternAnimation/TheTransformers'':
*** Dr. Arkeville, though his madness is one-upped by Starscream himself in "Countdown to Extinction".
*** Wheeljack of is one. Part of his appeal was him convincing the other Autobots that his crackpot inventions were worth something. His ''[[ComicBook/TransformersShatteredGlass Shattered Glass]]'' counterpart is also a mad scientist, but less the cheery genial type normal Wheeljack is, and much, much more pure distilled ranting TheyCalledMeMad type of mad scientist.
** Tarantulus of ''WesternAnimation/BeastWars'' is, if not a mad inventor, certainly crazy enough and scientific enough and treacherous enough to qualify for MadScientist. This is actually a case of CharacterDevelopment; in the first season, while he was the Predacon Science Officer, he was characterized more as "that creepy bot who'll eat ''[[ImAHumanitarian anything]]'' he can catch". This was AdaptationDisplacement--in the original toyline, he was a (still cannibalistic) ''ninja warrior''.
** ''WesternAnimation/TransformersAnimated'':
*** Prometheus Black. He started out messing around with biochemical enhancements to try and beat out Professor Sumdac's robotics industry, but after a lab accident changed him into the supervillain Meltdown he went into full vengeful mad science mode. The chemical warfare specialist Oil Slick might also count, although outside the fact that he's a ninja who developed the Transformer equivalent of ebola not much is known about him.
*** Blackarachnia also has elements of this. The [[AllThereInTheManual Allspark Almanac]] reveals she invented triple-changing, and her attempts to better understand her techno-organic mutation lead her to try and create another hybrid...resulting in [[FromNobodyToNightmare Waspinator]].
* Simon Bar Sinister, the main antagonist on ''WesternAnimation/{{Underdog}}'', a short, nasty-looking scientist only about two feet tall, who's goal was to TakeOverTheWorld. Unlike most examples of this trope, he tended to actually ''listen'' when his henchman Cad Lackey made suggestions.
* Dr. Thadeus "Rusty" Venture in ''WesternAnimation/TheVentureBros'', although his lack of ambitions and laziness mean that he comes up with far fewer superweapons and far more get-rich-quick schemes than most of his ilk. Other M.S.'s in the Ventureverse include Pete White and Master Billy Quizboy, Jonas Venture Jr., Otaku Senzuri from the lost pilot, Professor Impossible, Mike Sorayama, Dr. Septapus, Baron Ünderbheit (implied), and Phantom Limb (confirmed, as part of his backstory). Mad science occurs with such frequency in the Venture Bros. universe it's seen as a valid career path and given the politically-correct name "super-science".
* VillainProtagonist Dr. Flug of ''WesternAnimation/{{Villainous}}'' works as TheDragon to the GodOfEvil Black Hat, creating {{Genetic Abomination}}s and MechaMooks for his EvilInc. Most of the time he comes across as a meek MinionWithAnFInEvil, but very rarely [[SoftSpokenSadist displays a sadistic side rivaling that of his boss]]. He certainly has the "mad" part down however, as he [[TheFaceless constantly wears a paper bag over his head]] and has a strange obsession with airplanes (with his surname Flugslys [[MeaningfulName being Icelandic for "plane crash"]]) to the point he shoots them out of the sky with a shrink ray and keeps them in glass jars ([[AndIMustScream with the passengers still inside]]).
* ''WesternAnimation/TheWackyAdventuresOfRonaldMcdonald'': The main villain of "Birthday World" is an evil scientist named Professor Thaddeus J. Pinchworm, who takes advantage of Hamburglar's guilt at not getting Ronald a birthday present by inviting the gang to a theme park as a front for using Ronald and his friends as guinea pigs for his Babe-O-Matic Ray, which he intends to use to turn everyone else on the planet into babies so he could therefore rule the world on the basis of being the only remaining adult.
* Crossing this trope with {{Magitek}} is ''WesternAnimation/{{Wakfu}}'''s Season 1 BigBad Nox, a watchmaker who discovered that the most effective way of powering [[ClockPunk his inventions]] was [[PoweredByAForsakenChild draining]] [[LifeEnergy the Wakfu]] [[PoweredByAForsakenChild out of living organisms]]. A sampling of his creations include {{Vampiric|Draining}} {{Literal Surveillance Bug}}s, [[SpiderTank ambulatory pocket watches]], {{Killer Robot}}s powered by the residual substance of ''dead souls'' (generated in the first place by Nox's constant killing for wakfu), [[spoiler:[[TearJerker animatronic replicas of his dead children]]]]...
* Wallace from ''WesternAnimation/WallaceAndGromit'' is an eccentric AbsentMindedProfessor, although he usually uses his inventions for mundane things such as window-washing and humanely rounding up bunnies so they don't get in the way of the town's upcoming vegetable-growing competition. This has resulting in one case of mind-switching, Wallace turning into a Were-Rabbit, a penguin attempting to use his inventions for a jewel heist, and Wallace nearly getting killed several times. Luckily, his dog Gromit is loyal to a fault, an [[ShoutOut ace]] [[ComicStrip/{{Peanuts}} pilot]], and smart enough to be able to fix things whenever they go wrong (and they do, frequently).
* Doctor Two-Brains in ''WesternAnimation/WordGirl''.
** Tobey has managed to invent entire armies of giant robots at the ripe old age of ten.
* [[HarmlessVillain Jack Spicer]] on ''WesternAnimation/XiaolinShowdown'', although he seems to specialize almost entirely in robotics.
* Professor Crazyhair from ''WesternAnimation/YakkityYak'' is a fairly benign and friendly example, but is still mad.

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