* Matthew Denton of ''{{Heroman}}'', no question. He's the good version-also no question, because in the 2nd episode he gives many InTheNameOfTheMoon speeches about how [[TheAtoner the alien invasion is his fault and thus he must stop it]]. Most of the stuff he comes up with could not have been conceived by a completely sane mind, ([[RuleOfCool This is Anime]]) the most notable being a weaponized guitar that can kill cockroach aliens.
* In ''Anime/ValvraveTheLiberator'', we have Dr. Tokshima, a man responsible for creating what he calls a new life form, "homo sapiens novus", and is completely happy that they are superior to humanity. He laughs constantly, and compares himself to god in a somewhat funny, somewhat disturbing fashion, because its less of a dramatic declaration and more of a question he asks himself logically.
* Dr. Hell from ''Anime/MazingerZ''. In some versions (including the original manga), Juzo Kabuto is a mix of this and TheProfessor. And he has a handsome and HotBlooded grandson named Koji Kabuto, the main character.
* Doctor Gero of ''DragonballZ''
* In ''Anime/YuGiOh5Ds'', Akutsu (the scientist who developed the current Momentum generator) was certainly nutty enough to fit the Trope (and he did work for the BigBad of season one), but he seemed harmless.
* Professor Souichi Tomoe from ''Franchise/SailorMoon''. In the first [[Anime/SailorMoon anime version]] he was possessed by a demonic being that lived in his eye; in the [[Manga/SailorMoon manga]], he was just plain evil.
* Dr. Franken von Vogler from the ''GiantRobo'' OVA was introduced as a classic ranting Mad Scientist. [[spoiler:The series subverts this trope, as successive flashbacks reveal more about his real motivations.]]
* Icchan from ''KidouTenshiAngelicLayer'' is often mistaken for a Mad Scientist; he seems to encourage it, making over-the-top dramatic entrances, speaking cryptically about his creations whenever he can, and wearing his lab coat all the time.
** However, his invention makes sense, is based on diligent research, operates on the notion that the principles discovered in previous discoveries can lead to new ones, is dependent on capitalism to provide funds and is profitable for mankind in general. Mad Scientists everywhere are very, very disappointed in him.
* At least a third of the major characters in ''Anime/NeonGenesisEvangelion'' are mad, or at least amoral, scientists.
* ''Manga/{{Bleach}}'':
** Mayuri Kurotsuchi is an extreme example, a combination of MadScientist, MadDoctor and AxCrazy to boot, openly boasting of the thousands of souls he's experimented on in his studies. Yet he leads one of the Soul Society's 13 squads (his contains lots of [[QuirkyMinibossSquad quirky]] [[TheIgor assistants]]) and is a valued member. You begin to see the problem that the rest of Soul Society has with the administration.
** His Arrancar equivalent is Szayel Aporro Grantz, who shares his twisted science, represented the aspect of death known as "madness" and whose own QuirkyMinibossSquad existed solely to provide him with food whenever he needed to heal injuries. In the battle between Szayel and Mayuri, the fight ended up boiling down to which scientist was the most insane and the most capable of using that insanity in disturbingly creative ways. The winner, by a large margin, was Mayuri.
** [[spoiler:Aizen]] is one as well. His madness is quieter than Mayuri, harder to see until he's unmasked as the villain early in the story. As the story develops, his madness becomes more and more noticable as the stakes get higher and higher. His shinigami/hollow/human/[[spoiler:quincy]] experiments, however, have never been the experiments of someone with a sound mind, what with the constant killing ForScience and his [[AGodAmI "I will become God!"]] obsession.
*** Somewhat unusually for a Mad Scientist, [[spoiler:Aizen]] ''likes'' when his experiments don't produce what he wanted them to, finding it more interesting when something unexpected happens.
* ''Manga/FullmetalAlchemist'', instead of dealing with the Mad Scientist, revives its predecessor-trope, the almost forgotten Mad Alchemist (see below).
** There's Shou Tucker, who, under the pretense of having to produce good results in order to keep his license as a State Alchemist (although he later admits it was mostly [[ForTheEvulz "just to see if I could do it"]], [[spoiler: combines his own young daughter, Nina, and her pet dog into a chimaera, condemning them to a FateWorseThanDeath from which Scar is forced to release them via MercyKill.]] He doesn't fit the traditional profile of this trope (he appears quite calm and kind for most of the time we see him), but there is no doubt that he crossed the MoralEventHorizon on that one.
** TheMovie of [[Anime/FullmetalAlchemist the 2003 anime]] introduces a scientist who is severely ticked at the world's alchemists for making his work worthless. The "mad" part of this shows up when he reveals that he discovered Uranium and threatens the Elrics with a ''hand-held nuke''. Clearly he never tested the thing.
* ''WeissKreuz'' is almost as fond of these as it is of {{Mad Artist}}s - see particularly Takatori Masafumi, and Tsuji Mayumi in ''Weiss Kreuz: Glühen''.
* ''HajimeteNoAku''. The protagonist Jiro is a self-proclaimed Mad Scientist, Although in fact he seems to be incapable of doing anything evil.
* ''Franchise/LyricalNanoha''
** [[BigBad Dr. Jail Scaglietti]] of ''Anime/MagicalGirlLyricalNanohaStrikerS''. In fairness, it turns out that [[spoiler:he's an ArtificialHuman who was specifically created to be that way]]. Unlike most of the {{Gadgeteer Genius}}es here, actually refers to himself as an engineer. He also seems to be incapable of feeling anger and never falls in a VillainousBreakdown.
** [[SpellMyNameWithAnS Presea]] [[BigBad Testarossa]] from the [[Anime/MagicalGirlLyricalNanoha first season]], who snapped over the [[spoiler:loss of her daughter Alicia, spending centuries to find a way to revive her]].
* ''[[{{Gunnm}} Battle Angel Alita]]'': Desty Nova. Mad laugh, human experiments, cloning, nanomachines, lack of morals, the whole works, and he's ''proud'' of it.
* Dantalion the [[BossSubtitles Seeking Researcher]] from ''LightNovel/ShakuganNoShana''. He is [[LargeHam outrageously excitable]] and creates his mad experiments ForScience, and not necessarily for evil means. One suspects that if he weren't contracted to the bad guys he'd be mostly harmless. For BonusPoints, he looks exactly like Father Anderson from ''Hellsing''.
* Speaking of ''{{Hellsing}}'', there is The Doktor, chief scientist of the [[StupidJetpackHitler Millennium Group]].
* The eponymous Dr. Kishiwada of ''Dr. Kishiwada's Scientific Affection.'' Clinically insane and more than a little sociopathic.
* Ginias Sakhalin from ''Anime/MobileSuitGundamThe08thMSTeam'', the head of the Apsalus Project, which could be best described as a miniature [[Franchise/StarWars Death Star]] that kills cities instead of planets. He starts out relatively sane if overly dedicated, but he deteriorates as time goes on.
** He also has the [[MadScientistsBeautifulDaughter Mad Scientist's Beautiful Sister]]. Who is the [[DatingCatwoman hero's girlfriend]].
** Granted his looks are a bit more... [[{{Bishonen}} delicate and effeminate]] than this trope usually entails. As in, he looks more like a stereotypical hairdresser than mad scientist.
* The Elder in ''ChronoCrusade'' is a mild example of this trope. He's not ''completely'' insane, but his inventions tend to be quirky at best and downright dangerous at worst. Some of the things he's responsible for in the series include purposefully allowing [[HotBlooded Rosette]] to steal an experimental bullet with a demon trapped inside so he wouldn't have to test it himself, and apparently fusing a friend with demonic legion in order to make him a better fighter. Oh, and he's a DirtyOldMan to top it all off.
* Nina Einstein from ''Anime/CodeGeass'', a Teenage Mad Scientist Girl. She is particularly known for being a PsychoLesbian and inventing weapons of mass destruction.
** And the [[CargoShip table incident.]] [[NeverLiveItDown And the table incident.]]
** Earl Lloyd Asplund is an older, slightly more comedic version of the trope. His BunnyEarsLawyer status has earned him the FanNickname "Lloyd Aspie".
*** Lloyd plays with the trope as while he is eccentric and disrespectful, he is fully aware that he is a mad scientist. Also, he is the only (non-royal) noble in the series to have no lust for power and not be racist, and in that respect is in some ways the OnlySaneMan.
**** However, Lloyd plays it straighter in the AlternateUniverse manga ''Suzaku of the Counterattack'', where he willingly goes along with Prince Schneizel's plan to gain C.C.'s powers in order to ([[Website/ThatGuyWithTheGlasses you guessed it]]) TakeOverTheWorld, even though it could potentially destroy the Earth (and almost does, if not for the intervention of the heroes).
* Another one is Grace O'Connor from ''MacrossFrontier''. Though she doesn't heavily advertise that she ''is'' a scientist in the first place, in fact [[EvilutionaryBiologist she is]], and not the worst one. Given that she's also a HotScientist, and what a [[TheChessmaster scheming]], [[ForScience amoral]], and utterly {{badass}} [[MagnificentBastard Magnificent Bitch]] she comes in the end, it's simply unfair to leave her out.
* ''{{Sekirei}}'' has a few, but the biggest, craziest, and downright [[LargeHam hammiest]] of them all is Hiroto Minaka, MBI's [[CorruptCorporateExecutive psychotic and manipulative CEO.]] He's hinted to be behind the discovery of the original Sekirei and the making of the current ones, and is CONFIRMED to be [[ChessMaster manipulating every single person in the series towards his own bizarre ends]] and [[JerkAss making every character hate him in the process]], but earning [[DracoInLeatherPants massive fan love]] for his ImpossiblyCoolClothes and general {{Crazy Awesome}}ness.
* [[HeroicComedicSociopath Professor Franken Stein]] of ''Manga/SoulEater'', whose love of dissection is played for laughs early on. [[spoiler:The "mad" aspect becomes important later on, as madness is [[CosmicHorrorStory somewhat more concrete]] in this world.]] [[MagnificentBastard Medusa]] definitely counts as well. Eibon could count as this as well, in both the anime and manga, because not only does he eradicate the madness of knowledge but he teamed up with Arachniphobia (an evil witch) to invent his magic tools and demon weapons, although it seems as if he has truly benign intentions at heart.
** Stein's likening for cutting people up ''is'' played for laughs, but it's also what he seriously would have done to Medusa given the chance (and Spirit, and Maka, and Kid, and anyone he saw as interesting..). In the witch's case he settles for dismembering her and shoving a scythe blade into her skull for good measure.
* ''GetterRobo'' has a few. Saotome is the most famous example, though he's very low-key (except in the ''Armageddon'' OVA) about it and fairly normal on the surface. Professor Shikashima on the other hand has several screws loose (and indeed, actually ''has one lodged in his skull'') but his craziness is mostly played for laughs. In GetterRobo ?? [[spoiler:Hayato replaces Saotome as the leading scientist, with his trademark AxCrazy streak]].
* Some of the ''Manga/{{Naruto}}'' villains get into this, most notably [[SmugSnake Orochimaru]] and his MadDoctor BastardUnderstudy, [[TheMole Kabuto]].
** Madara is getting into this too, what with him collecting eyes, Zetsu army, and cloning Hashirama. Though you could argue he's not really a "mad" scientist so much as a douchebag scientist.
* Dr. Kaff from the Korean version of ''MazingerZ'', ''[[Animation/RobotTaekwonV Robot Taekwon V]]'' is a thoroughly ridiculous example of this, and a LargeHam who wants to TakeOverTheWorld.
* Hiroshi from ''MyDearMarie'' builds himself a RobotGirl [[ReplacementGoldfish who both looks identical and has the same name to a woman he has a crush on]]. When the two meet by chance, he tells everyone that they're [[LikeBrotherAndSister siblings]] as a cover story.
* [[Manga/FrankenFran Fran Madaraki]]. She's also a MadScientistsBeautifulDaughter (if you don't mind the stitches), who [[BodyHorror completely lacks]] any understanding [[NightmareFuelStationAttendant of the word]] squick. And she does half of it ForScience, and the other half to save lives... no matter the cost to quality of life.
* While Shiho Miyano of ''Manga/DetectiveConan'' may not qualify as a Mad Scientist, since she was forced into doing her research, her father certainly does. The series specifically mentions that her father was considered a mad scientist even by the standards of the Black Organization. That's pretty mad.
* One story in ''TheKindaichiCaseFiles'' features the story of a mad scientist who, during WWII, chopped up soldiers and tried to sew the pieces into the ultimate human. [[spoiler:It turns out that the ''real'' "mad scientist" was a pharmaceutical company that tested experimental drugs on six patients, all of whom died.]]
* The ''Anime/{{Pokemon}}'' anime loves this trope, especially for villains:
** Dr. Fuji, the ReluctantMadScientist who created Mewtwo for Giovanni [[spoiler:in hopes he'd be able to revive his dead daughter]]
** Professor Sebastian, who likes [[GadgeteerGenius messing with radio waves]] to lure Pokemon/force them to evolve.
** Dr. Namba, the campiest mad scientist on the list, who builds frequently ridiculous contraptions to capture Pokémon for Team Rocket, particularly Cassidy and Butch. [[BerserkButton Don't get his name wrong, whatever you do.]]
** Dr. Zager, another Team Rocket scientist, who assists Jessie and James in Unova and [[HighClassGlass sports a monocle]].
** Dr. Yung, from Mastermind of Mirage Pokémon, who [[spoiler:is revealed to be the titular "mastermind", attempting to take over the world with super-powerful Pokemon holograms]]
** Butler, in the sixth movie, [[spoiler:laughed out of Team Magma for a failed attempt to re-create Groudon]], who now travels as a circus magician, [[spoiler:but tries his experiment again using [[PoweredByAForsakenChild Jirachi as a power source]]]]and ends up having it work a little too well.
** Zero, the {{yandere}} villain of the eleventh movie, an assistant for an aborted project. After being abandoned by his mentor, obsession drives him to [[ThereIsNoKillLikeOverkill take reviving it a bit too far]]. And by "take it a bit too far" we mean "threatening anyone who stands in his way with poisonous gas or a [[HumongousMecha giant robot"]].
** Cyrus, leader of Team Galactic and OmnicidalManiac.
** Charon, official scientist of Team Galactic.
* Inverted with Irie, from ''VisualNovel/HigurashiNoNakuKoroNi''. While he did [[spoiler:do vivisections on people]], and does act a bit "[[{{Lolicon}} odd"]] toward Satoko, he's an honestly nice, smart father figure.
** But played terribly straight with his boss, [[spoiler:Miyo Takano]], who was perfectly willing to [[spoiler:kill the reported host of a HatePlague to make a village suffer the said plague]] ''just to prove that her grandfather wasn't mad''.
* ''Manga/HayateTheCombatButler'': Makimura Shiori seems to think that nursing robots need lots of missiles and rocket boosters. Unfortunately, most of her inventions either blow up or go berserk. In one episode, her boss asks her why all of her projects are complete failures. Her answer? [[StuffBlowingUp "Um, not enough firepower?"]]
* ''LoveHina'': Kaolla Suu is CrazyAwesome in that she's always gotta build bigger and better mechas based on the flying turtle, Tama-chan. These also explode on a regular basis. She even [[LampshadeHanging lampshades]] it in one episode by saying that having your creations explode spectacularly just seems like something a Mad Scientist would do.
** Kaolla Suu's name follows the "Western" order; that is, her surname (or family name) is Suu, and her given name is Kaolla.
* ''HollowFields'' is a manga about a school for mad scientists' children. The children get a classic education in things like making SteamPunk killer robots, making hideous animal hybrids, poisonmaking, and many, many other subjects.
* Dr. Schroeder from ''DarkerThanBlack'' is a nice old man, but, as a [[http://www.epicwin.org/2007/10/01/darker-than-black-24/ review]] put it, "just when you start thinking he's fairly normal, he goes on a slightly psycho, childish rampage".. He only wants to rid the Earth of the AlienSky that shut all space programs down. The side effect he ''expects'' would be [[spoiler:killing as many people as there are stars in the sky]]. A problem not explored in series is that there's [[NoPlansNoPrototypeNoBackup no way to test]] his project and ensure that in process the whole Earth will not suffer the same fate as all those vanished rockets, turn into one big [[RealityIsOutToLunch Gate]], etc. ''He'' is quite sure his theory will work out ''exactly'' as he expects, so WhatCouldPossiblyGoWrong?
** Dr. Etou from the ''Shikkoku no Hana'' manga, on the other hand, is a [[SlasherSmile grinning]], stuttering and almost drooling specimen -- when his superior [[DopeSlap snaps him out of rants by punching]] this doesn't even look like needless cruelty.
* Yoshizumi-sensei of ''ZombieLoan''. He started off as a reasonably sane college scientist, but when [[spoiler:Caramelo]] of the ARRC turned him into a zombie, he [[GoMadFromTheRevelation snapped]]. He ends up [[spoiler:merging with his "masterwork", the Phalanx, only to be killed by Sawatari.]]
* ''Anime/HanaukyoMaidTai''. Head maid of the Technology Department Ikuyo Suzuki sometimes becomes one of these. When she does so, her spectacles become ScaryShinyGlasses. In ''La Verité'', her face usually gets distorted as well.
* Okabe Rintaro (or [[LargeHam HOUOIN KYOUMA!]] as he sometimes prefers to be called) of ''SteinsGate'' is a self-proclaimed example, often prone to peals of EvilLaughter, bouts of paranoia, and referring to his inner circle of friends as lab members. Yet despite all of this, he can be surprisingly grounded at times, and realizes that he and his friends' dabbling in time travel and poking about a GovernmentConspiracy could land them in very hot water.
* Rinichiro Hagire, from ''DeadmanWonderland''. He found a way to overwrite people's memories with his own, so that his conscious could continue to live through another's body, completely under his control. He also started a macabre carnaval in his search for the strongest Deadman for his next "generation." Death was expected by the loser. At the time of the [[spoiler: the Wretched Egg's birth, he was testing human immunity, searching for a way to improve it, and eventually created the Deadman]], he is now [[spoiler:trying to turn of the MGS so that Shiro can be at FULL POWER which caused a huge earthquake when she first awoke, submerging the entire city of Tokyo]].
* Doc from ''{{Texhnolyze}}'', who doubles as a HotScientist. Putting aside her prosthetic limb fetish and her tendency to have sex with her patients, she also puts wheels on a rat for no reason other than her own apparent amusement.
* Dr. Hogback from ''OnePiece'', who builds zombies for his master Gekko Moriah, and has no respect for life despite being a doctor.
** From the Punk Hazard arc, we have Caesar Clown, who's an even bigger asshole, and even more nuts (Watch out, loads of spoilers ahead). [[spoiler: He kidnapped and experienced on children, and used a very dangerous drug on them to keep them from escaping, he has absolutely zero respect for anyone, his forte is [[WeaponOfMassDestruction weapons of mass destruction]], he acts like a nice guy to his underlings only to perform more experiments on them later, he caused an incident that made Punk Hazard into a wasteland, then collected the leftover poisonous gas from that incident to make a BlobMonster, which he later changed ''back'' into an even deadlier gas that petrifies its victims]]... What makes it even worse is that [[spoiler: a [[TheMole mole]] in the Marines covers up all of his actions, allowing him to do as he pleases]].
* [[spoiler: Ivan Alexandr]] in ''{{Manga/Marginal}}''. He is obsessed with the womb and runs away to [[spoiler:Earth]] so that he can freely experiment with creating [[ArtificialHuman hermaphrodites]].
* ''LightNovel/{{Baccano}}'' has Szilard Quates, Huey Laforet, and Renée Brinvillier. All three are immortal alchemists, and also happen to have [[MadScientistsBeautifulDaughter the requisite beautiful daughter]] (with the latter two sharing theirs).
* Izaya Orihara of ''LightNovel/{{Durarara}}'' is what happens when a mad scientist tries his hand at sociology. Note that this ends up being impossible to distinguish from a {{troll}}.
* ''Anime/MobileSuitGundam'' has a rather tragic example with Tem Ray, Amuro's father. Originally he was a decent man (if very distant to his son), but when their home colony is attacked he gets pulled into space and suffers brain damage due to oxygen deprivation. The next time Amuro sees him, he's in a basement cobbling gobbling electronics into "upgrades" for the Gundam and rambling to himself.
* Hange Zoe of ''Manga/AttackOnTitan'' is a heroic example, being the [[CloudCuckooLander eccentric]] head of Titan research for the Survey Corps. Hange has some aspirations towards being a FluffyTamer, but is also responsible for a good percentage of what humanity knows about Titans. Traps, zany experiments involving [[spoiler: Eren performing tasks in titan form]], and generally terrifying bystanders is business as usual.
* Akihiro Kurata from ''Anime/DigimonSavers''.
* Hakase Saotomi and Chao Lingshen from ''MahouSenseiNegima'', refer to themselves as having sold their souls to science.
----