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* In ''VideoGame/AmericanMcGeesAlice'' the Jabberwock is the only villain who stays dead after Alice defeats him, and is never revived later. The most likely reason for this is that, due to [[BreakingSpeech what he says to her]], he is the embodiment of the guilt she feels over the death of her family. Because the guilt is something she is able to completely rid herself of at the end of the first game, he truly dies.
* ''VideoGame/BatmanArkhamCity'' concludes with the death of The Joker. Yes, even despite having JokerImmunity. Even Commissioner Gordon is stunned by the news. Creator/MarkHamill has since tweeted that he had a great time playing the Joker, but he won't be doing so anymore.
-->'''Batman''': "Do you want to know something funny? Even after everything you've done, I would have saved you."
--> '''Joker''': ''[laughing and coughing uncontrollably]'' "[[ActuallyPrettyFunny That actually is... pretty funny...]]"
** Then Hamill did more work as the Joker and said that he never detailed his retirement from the Joker character even though he widely pronounced it.
* Several characters die in ''VideoGame/BlazBlue'', but due to the GroundhogDayLoop the game takes place in, no one ''stays'' dead. There are, however, two exceptions to this: [[SNKBoss Nu-13]], who dies at the end of ''Calamity Trigger'', and [[TheWoobie Lambda-11]], who performs a HeroicSacrifice in ''Continuum Shift'''s True Ending. As of the True Ending of ''Continuum Shift'', the GroundhogDayLoop is broken, so anyone who dies from here on out dies for good. Given the [[DarkerAndEdgier tone]] [[AnyoneCanDie establ]][[TheBadGuyWins ished]] [[CrapsackWorld so]] [[BittersweetEnding far]], expect more entries to be added here soon.
** And indeed. By the time of the [[VideoGame/BlazBlueChronoPhantasma real sequel]], there are no Murakumo unit characters.
*** Not anymore: Mu comes back due to Rachel, Nu wills herself back and a new Murakumo is said to come. [[spoiler:Said Murakumo being the Prototype, Izayoi, AKA Tsubaki Yayoi's Ars Armagus.]] This trope is still played straight for Lambda-11, though.
*** [[spoiler: Yuki Terumi/Hazama and Trinity Glassfield (both of whom were sort of already dead) are gone for good as of Chronophantasma; the former offing the latter, after his end at Hakumen's hands.]]
* After coming BackFromTheDead some 20 times over the course of the ''Franchise/{{Castlevania}}'' series, Dracula finally gets destroyed for good in an untold event prior to the game ''AriaOfSorrow''. He tries to reincarnate, but Soma Cruz (the would-be reincarnation) wants nothing to do with it, and thus Dracula stays dead. People argue about to what level Soma is Dracula, but it's kind of a meaningless argument, as the games following it are all set ''before'' ''Aria''.
** And the event in question hasn't been put into a game yet!
*** [[ContinuityReboot And it won't]].
* In ''VideoGame/CliveBarkersJericho'', a game in which the main characters make up an army-based squad of people with supernatural powers, two of whom who have the ability to bring recently-deceased squadmates back from the dead provided that they maintain visual contact, has both Simone Cole and Xavier Jones being killed off (extremely horribly) towards the end of the game, when the Firstborn decides to '''blow them into bloody pieces''', with no chance of revival even remotely possible.
* ''VideoGame/DarkSouls'' does this to ''[[AnyoneCanDie a lot]]'' of {{N|onPlayerCharacter}}PCs. Oddly enough, when they die or are killed by you, they die for real despite the Darksign supposedly bringing people back from the dead repeatedly.
* In ''VideoGame/DonkeyKongCountry'' and related games, Wrinkly Kong dies between ''Donkey Kong Country 3'' and ''VideoGame/DonkeyKong64''. She does remain in the series as a ghost, however.
* Any non main spirits that fall in battle in ''VisualNovel/EienNoAselia'' are killed off. Main spirits result in a game over. On the first playthrough, [[spoiler:Kouin and Kyouko]] are killed off and can be in later playthroughs as well if you don't do the third chapter exactly right.
* ''Franchise/TheElderScrolls'' series provides several examples of this. We won't be seeing much of the [[VideoGame/TheElderScrollsIIIMorrowind Tribunal]], [[VideoGame/TheElderScrollsIVOblivion Mankar Camoran]], or [[VideoGame/TheElderScrollsVSkyrim the loser of the civil war questline]] ever again, for instance. Daedra avert this (they cannot be truly killed), as do "essential" [=NPCs=] from ''Oblivion'' onwards. It should also be noted that any NPC (save aforementioned "essential" [=NPCs=], who are merely knocked out by lethal force) killed by the player is this, and ''Morrowind'' will warn you that "The chain of prophecy has been broken" (translation: [[UnwinnableByDesign "Good luck completing the main quest now!"]]) should you manage to kill off, say, Caius Cosades, Vivec, or another important Main Quest figure.
* The ''VideoGame/EscapeVelocity'' and ''[[VideoGame/{{X}} X-Universe]]'' series feature play modes whereby the ''player'' gets Killed Off For Real if he dies (you can't reload your save because the game deletes it), called "Strict Play" and "Dead-Is-Dead" in their respective series.
** Borders on NintendoHard in the ''X-Universe'', because the game can't distinguish between dying because your ship got shot to pieces and dying because the RandomNumberGod decided to [[TeleFrag make a cruiser crash into you at a jumpgate]]. (In fairness, that would be really hard to code.)
* DoubleSubverted in ''Videogame/EvilGenius''. Each of your henchmen has 3 lives prominently displayed in their character pane, so if their HitPoints fall to zero three times they're gone, right? Yet as you play the game and this happens repeatedly, the life counters won't budge. The reason is that only a Super Agent can kill a henchman to the extent of losing a life -- if they die ''that'' way three times, ''then'' they're not coming back.
* The ''Franchise/FinalFantasy'' series has had its share of permanent character deaths.
** The very first such death in the series dates back to ''VideoGame/FinalFantasyII'', in which Josef makes a HeroicSacrifice. In fact, for a large part of ''VideoGame/FinalFantasyII'' the 4th party slot exists solely to accommodate a character who will die in some heroic fashion for the sake of the three main characters at some point. There were so many that you form a party from the deadin the GBA and PSP remakes for a bonus dungeon.
** In ''VideoGame/FinalFantasyIV'', [[HeroicSacrifice Tellah dies]] after casting [[EleventhHourSuperpower the ultimate magic Meteo to defeat Golbez]]. In a title positively ''dripping'' with {{Unexplained Recover|y}}ies, this is more a little jarring. [[FourIsDeath It's also the fourth game in the series, and Tellah is the fourth character to join your party, and the game subverts]] KillEmAll with said {{Unexplained Recover|y}}ies.
*** To add insult to injury, [[SenselessSacrifice Golbez survives]].
** In ''VideoGame/FinalFantasyIVTheAfterYears'', a number of characters can be Killed Off for Real if you screw up. In Rydia's Tale, Calca and Brina will, after glitching due to magic, be scrapped in order to repair the airship, unless you get the Mythril parts. In Edge's tale, All fo the ninja under Edge will die for real if you die during their mission before meeting back up with Edge. Time for some SaveScumming! And in the final chapter, It's possible to lose Golbez forever.
** In ''VideoGame/FinalFantasyV'', Exdeath kills Galuf in a duel. Levelling him up all this time is not in vain, as he imparts all his knowledge to the character who takes his place.
** In ''VideoGame/FinalFantasyVI'', General Leo is killed in a cutscene after the first and only time you get to use him in battle. Shadow will die for real if you don't wait for him on the Floating Continent.
** The most memorable of such deaths happened in ''VideoGame/FinalFantasyVII'', when Aerith is suddenly stabbed right through her back by [[spoiler:an avatar of Jenova assuming the form of]] the main villain Sephiroth. Although there [[UrbanLegendOfZelda are many rumours about resurrecting Aerith in some way created by fans]], the only way to do so is through some cheating device (which invariably messes up your game anyway). May be spoilers, but [[ItWasHisSled surely you've heard of this by now]].
*** Aerith is able to communicate beyond the grave, however, in her spirit form. She can even use Limit Breaks beyond the grave. And cure cancer. [[spoiler:Zack and Angeal]] similarly are dead for good, though only the former can communicate beyond the grave.
** ''VideoGame/FinalFantasyX'' sets you up to think this is going to happen to Yuna. In the end, Yuna lives (obviously, since she's the star of the sequel), but both Tidus and Auron really do die for real. Well, Auron was ''already'' dead, but he still sorta counts. Although, the perfect ending of both ''FFX'' and ''[[VideoGame/FinalFantasyX2 FFX-2]]'' shows Tidus apparently alive and well. The FFX-2 one even shows Yuna reuniting with him.
*** Tidus is an animated dream of several dozen dead people, so technically, he was never really "alive" to begin with. Though this depends on WhatMeasureIsANonHuman.
** In ''VideoGame/FinalFantasyXIII2'', Serah has one last vision before dying at the end of the game.
* This is built into the gameplay of ''Franchise/FireEmblem''. If one of your units reaches zero hitpoints, they die and are unusable for the remainder of the game, unless they happen to be important to the plot in which case they are merely "wounded" but still are unusable.
** A few have subverted it, though. ''Fire Emblem Gaiden'' had resurrection springs (though reaching one was a sidequest in itself); more recent ones have had resurrection staves... though they have limited irreplaceable charges, so if you run out, anyone else who dies is still dead forever.
*** In addition, in ''Fire Emblem: Rekka no Ken'', during the first 10 chapters (Lyn's story), party members will not die, instead only being wounded and unable to be used until after chapter 10. This is also due to the fact that the first 10 chapters are meant to be the tutorial levels.
** Similarly, ''VideoGame/FinalFantasyTactics'' has party members die for real if they are not revived after 3 turns when their HP hits zero. This also counts as an instant game over if Ramza is killed. Guest units are simply knocked out instead of dying unless the mission conditions state otherwise.
*** ''VideoGame/FinalFantasyTacticsAdvance'' eases up on the concept of party members dying for real, restricting true death to Jagds where party members can die if they are not revived before the battle ends. This is explained in the story where judges and the laws prevent death and the Jagds are places where laws cannot exist, thus people can truly die and only the most hardened clans are willing to have battles in those areas.
** ''VideoGame/FireEmblemJugdral Genealogy of the Holy War'' takes it a step further: During Chapter 5, Cuan and Ethlin, who were previously in your party but are now [=NPCs=], get ambushed by Trabant and both of them are killed. Yes, characters that were once in your army are now dying without your control. At the ending of the same chapter, all of the first generation (with the exceptions of Levin and Tiltyu, although she [[KillTheCutie dies anyway]] in [[TimeSkip the interim]]), which is nearly '''half of the game's cast''' are killed when Alvis betrays Sigurd.
* Zato-1 from ''VideoGame/GuiltyGear''. His voice actor died, and they didn't want to use anyone else for the character, so they killed him off. Doesn't stop people from saying he should return. Conveniently, his character story involved being menaced by a psychic parasite he gained as part of a bargain to trade his eyesight for power, so they had said parasite kill him and take over his body, writing him out of the story but keeping his moveset and sprite in the game.
** The death of this same voice actor (Creator/KanetoShiozawa) also necessitated the killing off of another his characters, ''VideoGame/RivalSchools''' Hyo Imawano at the end of ''Project Justice''.
* As of ''Halo 4'', both Cortana and The Didact. Cortana dies from rampancy like all other AI eventually do and the Didact is given a one way fall into a slipspace portal, annihilating him.
* ''VideoGame/HeavyRain'' features permanent death, even making it possible to have a standard ending with all of the playable characters dying.
** Funnily enough, two of the characters have PlotArmor that doesn't come off until endgame. Those two are Ethan - who can be killed by the police or commit suicide - and Shelby - who dies either by getting shoved into a grinder by Jayden, shot by Jayden/Ethan/Lauren, or impaled by Madison.
* In ''VideoGame/{{Inindo}}'', characters on your party will be "injured" if they fall in battle. If you continue to fight with them, falling in battle again will likely result in permanent death. Likewise, potentially playable characters will randomly attack the main character while he rests. Defeating them either results in their surrender, or permanent death.
* While most of the original characters' deaths in Franchise/KingdomHearts have been {{Disney Death}}s, thanks to the way hearts work in that universe, there have been a few notable exceptions: [[VideoGame/KingdomHeartsChainOfMemories the Riku Replica]], [[VideoGame/KingdomHearts358DaysOver2 Xion]] and [[VideoGame/KingdomHeartsBirthBySleep Eraqus]]. Roxas and Naminé by the end of VideoFame/KingdomHeartsII and Vanitas in [[VideoGame/KingdomHeartsBirthBySleep Birth by Sleep]] might also count, depending on how you view their respective situations. Of the entire lot, though, [[TheObiWan Eraqus]] and [[FanNickname Repliku]] look like they might be the only ones who are almost assuredly going to remain this trope.
* The power of Orochi vaporized Rugal Bernstein at the end of ''VideoGame/TheKingOfFighters '95''. Yashiro Nanakase and his whole team take their own lives to empower Orochi's incarnation at the end of ''The King of Fighters '97''.
* Both ''VideoGame/Left4Dead'' games treat dying as DeathIsASlapOnTheWrist since dead players can come back later on in a closet, the next map (both representing the gathering of fellow survivors in ZombieApocalypse stories), or be revived with a MagicalDefibrillator. You don't get to respawn in a finale, since there are no closets. Realism and VS modes also enforce the trope.
** Also, Bill sacrificing himself to raise a drawbridge so the others could escape at the end of the first game. You find his corpse in the second game, and there is no way to bring him back.
* In ''VideoGame/TheLegendOfZeldaTheWindWaker'', this is highly implied to be the case with [[spoiler: Ganondorf]], as he hasn't appeared in any of the ''Wind Waker'' timeline sequels, only being a mere mention.
** Also implied in ''VideoGame/ZeldaIITheAdventureOfLink'': Ganon's minions need Link's blood to revive Ganon. This is said to be the ONLY way to revive him at this point, since Link took the Triforce of Power from him after his defeat.
* The trope caused something of a problem for the very lore-conscious designers of ''VideoGame/TheLordOfTheRingsOnline''. Since resurrection (or even magical healing) of any kind is exceptionally in Franchise/TolkiensLegendarium, the dev team came up with a semantics-based gimmick to stave off the need for either: the player's green life bar doesn't measure life, it measures morale. Players are explicitly never referred to as being killed, only "defeated". Running out of morale represents the player losing the will to fight and fleeing the battle. Hope and Despair, a pair of super-buff/debuffs that represent overall mood, even cut or add to morale.
* In ''VideoGame/{{Mass Effect|1}}'', on Virmire, Shepard has to leave either Kaidan or Ashley behind as a nuke goes off. Wrex can be killed earlier in the mission if you fail to secure his loyalty. [[WordOfGod BioWare has explicitly said]] that the dead party member(s) will not return in the sequels, potentially solidifying the series' listing under this trope.
** ''VideoGame/MassEffect2'''s final dungeon requires a coordinated attack using your entire squad, in which you must assign characters to perform certain tasks (hacking a door, leading a squad, etc). Picking the wrong characters for certain roles will get them permanently killed off. Depending on how you resolve your party's loyalty quests, Shepard him/herself may not survive, either. A save file with this ending cannot be imported into ''VideoGame/MassEffect3''.
** Obviously, characters who died in the first two games don't appear in ''VideoGame/MassEffect3''. Of the squadmates who can survive through to the third game, two (Thane and Legion) are guaranteed to die no matter what choices you pick, one (Mordin) can only survive if another squadmate (Wrex) is dead or killed, and several others (Jack, Miranda, Tali, Grunt, Samara, Zaeed) can die depending on the choices you make. Additionally, Shepard dies in all of the endings except for one variant of the "Destroy" ending.
* Zero, throughout the entire ''VideoGame/MegaManX'' series, has been killed and resurrected several times already. However, at the end of the ''[[VideoGame/MegaManZero Zero]]'' series, he is never coming back, with a HeroicSacrifice that will last.
* ''VideoGame/{{Metal Gear Solid 2|SonsOfLiberty}}'' has a character named Vamp who, no matter how many times he'd seemingly "die," he always comes back to life. ''Metal Gear Solid 4'' explained this as a result of nanomachines enhancing his already powerful healing factor, and once Snake disables them with a syringe, Raiden is able to kill him off for good.
** ''VideoGame/{{Metal Gear Solid 4|GunsOfThePatriots}}'' ties up the Solid storyarc with ''lots'' of this. Big Boss, who was [[HesJustHiding just hiding]], is finally Killed Off for Real, as is Solidus. The same might safely be said for Ocelot but he's... [[MagnificentBastard well, you know]].
* In ''VideoGame/MortalKombat9'', the SequelHook offers hope that ''most'' of the slain heroes might be restored. [[spoiler:Shang Tsung, however, given how he was killed, is likely toast.]]
** This happens to [[FinalBoss Blaze]] at the end of ''VideoGame/MortalKombatArmageddon'', no matter which character's ending it is.
* Surprisingly, Gameloft's ''VideoGame/MyLittlePony'' iPhone game has this happen to Queen Chrysalis (and every other Changeling in Canterlot). At the end of the "Canterlot Wedding" event/level, they're ''vaporized'' by the Elements of Harmony. Rainbow Dash even says they'll "Get rid of these Changelings once and for all", which leaves little room for ambiguity.
* [[spoiler:Shandra Jerro]] in ''VideoGame/NeverwinterNights2''.
* In ''VideoGame/{{Persona 3}}'', Shinjiro Aragaki bites it a mere month after he joins your party. And so does Junpei's love interest, Chidori (though in the FES version of the game, it is possible to resurrect her). And in the very end, the Main Character sacrifices his life to save the world.
** It's also possible to save Shinjiro in the PSP version.
* This is Nanako's fate in the [[MultipleEndings worst ending]] of ''VideoGame/{{Persona 4}}''. However, that's only if you ''really'' screw up. In every other scenario, she suffers a mere DisneyDeath.
* The VideoGame/PhantasyStar series also exhibits this with respect to main characters:
** In ''VideoGame/PhantasyStarII'', Nei is either killed by [=NeiFirst=] completely overpowering her or dies after killing [=NeiFirst=] due to them being part of the same original being - even the Clone Shop says that nothing can be done. Subverted in the Sega Ages remake - after completing a process that can only be described as GuideDangIt on a MASSIVE scale, Nei is resurrected without fanfare at the Clone Shop as if it was a normal combat death.
** In ''VideoGame/PhantasyStarIV'', Alys Brangwin is hit by, declines from, and permanently dies [[HeroicSacrifice due to saving the main protagonist Chaz Ashley]] from the Dark Energy Wave. It is specifically mentioned that healing techniques do nothing to help as her health declines.
* It is strongly implied that [[BigBad Lysandre]] is, indeed, killed in ''[[VideoGame/PokemonXAndY Pokemon Y]]''; he is directly hit by the death ray of the Ultimate Weapon after foolishly activating it in rage after being defeated by the player, making him the first character in a main Pokémon game (even the DarkerAndEdgier ''VideoGame/PokemonColosseum'' ironically), to canonically die. It is vaguely suggested that he's still alive in the ''Pokémon X'' version, but his fate there is [[AndIMustScream even worse]]...
* ''VideoGame/RatchetAndClankFutureACrackInTime'' features an impressive deathcount of important characters: Clank's father Orvus, Alister Azimuth, Lord Vorselon, Cassiopeia, Carina and Libra, Pollyx, and Ratchet, though he gets better.
* After being an immortal villain for almost the entire series up until ''VideoGame/ResidentEvil5'', Albert Wesker turned into a monster and was finally -according to WordOfGod- [[http://ps3.ign.com/articles/100/1006931p1.html killed for good]]. Word of God ''also'' said ''Franchise/ResidentEvil'' would definitely [[FlipFlopOfGod never come back to the PlayStation]], so make of that what you will.
* ''VideoGame/Rockman4MinusInfinity'' had Shadow Man escape from every battle until his last battle. He falls off the kite and dies with an offscreen explosion.
* In ''VideoGame/SamAndMaxFreelancePolice'', [[spoiler:Max dies in his EldritchAbomination form]] in the Season 3 finale, ''The City That Dares Not Sleep''. Specifically, [[spoiler:he was transformed into [[EldritchAbomination a giant Cthulhu-rabbit hybrid]] in the fourth episode, and at the end of the fifth episode, seconds before he is saved by the Narrator, he gets hit by one of the Maintrons and teleports to Stinky's cell phone before it goes off.]] Despite being the perfect set-up for a GrandFinale, [[spoiler:[[ChekhovsGunman Max's time-travel paradox duplicate from 204]] re-appears soon after Maxthulhu's death, implying future adventures.]] The current body count for that episode also includes everyone caught in [[spoiler:Max's explosion]], i.e. everyone on [[spoiler:Skun-ka'pe's ship]] (To be more precise: [[spoiler:Max, Sammun-Mak('s brain), Gra-pea'pe in Grandpa Stinky's body and Girl Stinky]]), as well as [[spoiler:Sal and possibly Sam Jr]] earlier in the episode.
* The MMORPG ''Shaiya'' does this to players playing on [[HarderThanHard Ultimate Mode]]. While you have access to the most powerful weapons and equipment on that difficulty level, if you don't get revived by an ally within three minutes of your character's death, that character's data is ''erased'', and you have to start all over.
** There is actually an AP item (premium item that you have to pay REAL money for) called "Character Revival". It costs 7500 AP. The exchange rate of AP to USD is approximately 100:1 (i.e., it'll cost you $75). However, seeing as how you have to reach level 40 on both Normal and Hard mode (no mean feat, if you don't use AP items and have a life outside of playing the game) to be able to create an Ultimate mode character in the first place AND it takes 4x the normal XP to level such a character, it may be worth it.
*** NOTHING is worth 75$ in an online game!
* This happens to Harry Mason in ''VideoGame/SilentHill3''.
* ''{{VideoGame/Skullmonkeys}}'', the sequel to ''VideoGame/TheNeverhood'', applies this trope to the BigBad of both games, Klogg. To really drive it home, they even [[http://www.youtube.com/watch?v=4BUmv8imdH0 sing it!]]
* E-102 Gamma in ''VideoGame/SonicAdventure''. After the battle with E-101 Beta, he self-terminates himself to free the last trapped bird.
** This also applies to all {{Big Bad}}s who are not Robotnik, Chaos or Metal Sonic.
* Tassadar, in the original ''{{Starcraft}}'', dies to save the galaxy from the original Zerg Overmind. It is completely real, as far as video games go: he gives a stirring speech to those who will live on after him, to remember what was done there that day, which is then followed by the cinematic of him effectively blowing himself up via his awesome psionic abilities, and taking the Overmind with him. In sequel games, the death is so complete that the Protoss change their usual greeting of "An'taro Adun," which effectively means "May Adun protect you," to "An'taro Tassadar." If he were brought back, it would destroy half the ''Starcraft'' canon.
** In the sequel, it seems that Blizzard has managed to do just this without ruining the canon. Tassadar comes back just long enough to warn Zeratul of the impending apocalypse in the capacity that Obi-wan does in ''StarWars'', as a sort of Force ghost, or Khala ghost, as it may be.
** Many other characters are also killed, most of them in the Brood Wars expansion and some in official (or authorized) side campaigns. Other than obviously the Overmind (and the new Overmind formed to replace it); these include Raszagal, Gerard [=DuGalle=](suicide), Edmund Duke, Fenix (died, came back, then Killed Off for Real), Aldaris, Alan Schezar, probably Ulrezaj, Atticus Carpenter, Edullon, Jack Frost and EVERY ZERG CEREBRATE. Most of these are unlikely to come back, however it is not impossible as Fenix came back once before dying again, and it turns out Alexei Stukov is definitely BackFromTheDead. Even so, the only ones likely to come back are the cerebrates...and probably not the same ones. Other characters also die in other media, such as the novels.
** And FINALLY, Kerrigan kills [[spoiler: Mengsk. [[BoomHeadshot Oh]] [[MoreDakka yes]]. And possibly Lt. Duran, if he wasn't just Narud's brother]].
* DummiedOut in ''VideoGame/StarWarsTheOldRepublic'', at least in regards to companion characters, for game balance reasons.
* ''VideoGame/SteelBattalion'' does this WITH THE PLAYER. The game is so determined to present the most realistic mecha combat simulation possible, that there is no way to resume a game after you die; when your mech is close to blowing up, you are given ample chances to eject. If you don't, and your character dies, it ERASES YOUR SAVE.
* In the ''VideoGame/{{Suikoden}}'' series, your characters may randomly die for real if defeated in a large-scale war battle.
* Most of the [[Franchise/SuperMarioBros Mario]] villains benefit from JokerImmunity, especially Bowser who either survives his battles with Mario or on occasion gets revived from them. The [=RPGs=], however, are not so forgiving, [[MarioAndLuigiSuperstarSaga Cackletta]] is the first Mario villain to outright ''die'' (they even [[DeaderThanDead destroy her ghost]] for good measure). The [[PaperMarioTheThousandYearDoor Shadow Queen]], [[SuperPaperMario Dimentio]], [[DragonAscendant Fawful]], and [[MarioAndLuigiDreamTeam Antasma]] follow, though Fawful managed to last more than one game.
* After beating Aim in VideoGame/{{Super Robot Wars Z}}2: Saisei-Hen during Scenario 52 of the ZEXIS route or Scenario 57 of the Zero Requiem route, he regenerates from all his wounds. [[http://www.youtube.com/watch?v=X3Ix4aPAVVQ Asakim, who managed to escape from the ZONE with help from Gaioh, arrives on the scene. Thanks to his time trapped in the ZONE, Asakim has learned how to utilize the power of the spheres in his possession. He invokes the power of the Inquisitive Goat which reveals Aim's past.]]
** It seems Aim's real name is Hamal Argo and he was once a researcher who built his career based on lies. Forced to face this truth, Aim's Sphere is weakened to the point of deactivation. Uther soon arrives, makes short work of Aim and takes his sphere.
* Wingmen who get killed in ''VideoGame/TachyonTheFringe'' stay dead. The exception is the [[FunWithAcronyms JASPER]] robots, who are mass-produced and replaceable.
* In ''VideoGame/TalesOfTheAbyss'', Iemon, Tamara, Hencken and, Cathy are killed and later on Frings is killed by replicas. As well as the Six God Generals minus [[GainaxEnding Asch]] and [[MadeOfIron Dist]]
* In ''VideoGame/TalesOfDestiny'', Leon Magnus [[TheReveal spills half the game's plot]], just before drowning himself by filling the cave the party is in with floodwaters for no apparent reason. Way to go.
* In ''VideoGame/TalesOfLegendia'', Stella after performing a HeroicSacrifice and later [[KillTheCutie Fenimore dies too]].
* In ''VideoGame/TalesOfSymphonia'' this is both played straight ''and'' subverted all at once, due to MultipleEndings. If you pick the path where you fight Zelos, he dies and dies for real. It's subverted, though, because thanks to the OVA and especially the sequel, this is revealed to be the non-canon path; in the canon path, he lives.
** There are some minor characters who don't escape, though, including Botta.
* ''VideoGame/{{Tekken}}'' has several cases of this, especially after the time skip and Ogre attacked and absorbed several characters' abilities, with suspicions that he killed them for good. But most characters later were brought back in the latter installments, thereby setting up that the only one Killed Off for Real were Jun Kazama and the original King. Not to worry, they got their successors all right (Asuka and the second King).
** Armor King was another case where at first, he's thought to be Killed Off for Real outside the Ogre interference (Marduk killed him), but he reappeared in ''Tekken 5: Dark Resurrection''. However, his personality is rather different, raising predictions whether Armor King really came BackFromTheDead, or it's Armor King's successor and the first Armor King was really Killed Off for Real.
*** ''Tekken 6'' reveals that the Armor King who attacked Craig is the brother of the original Armor King; he even used the same outfit and stage name alongside his brother at the same time.
** Kunimitsu was supposedly killed off for real by Yoshimitsu in ''Tekken 2'', although there's no official WordOfGod.
** The [[WordOfGod official statement]] ([[http://www.computerandvideogames.com/226228/interviews/tekken-6-your-questions-answered/ see here]]) is that only King I (killed by Ogre) and Armor King I (dying from [[IncurableCoughOfDeath some]] [[BloodFromTheMouth disease]] he picked up around the time of ''Tekken 2'', later killed in a bar brawl by Marduk pre-''Tekken 4'') kicked the bucket. Jun is [[HesJustHiding apparently just hiding]] (she's [[TheBusCameBack set to return]] [[http://www.youtube.com/watch?v=ieWp4FvXxk8 in the non-canon]] ''Tekken Tag Tournament 2''), as is Kunimitsu (maybe) and the first Kuma is also [[HesJustHiding apparently just hiding]].
* In ''VideoGame/ValkyriaChronicles'', Isara dies on the Marberry shore, after her latest invention, the smoke shells, save her squad. In a case of GameplayAndStorySegregation, Isara and many other characters who were in fact killed off for real, such as Selvaria, are secret unlockables in Valkyria Chronicles
* Turned into a core game mechanic in ''VideoGame/ValkyrieProfileCovenantOfThePlume''. Activating the titular item [[SuperMode maxes out a character's stats]], at the cost of [[DeadlyUpgrade having them die permanently at the end of the battle]].
* Speaking of Telltale games, ''VideoGame/TheWalkingDead'' has this in spades-and they make sure you feel it. In the first episodes, they feature not one, but two SadisticChoice scenarios, one of which resulting in either [[spoiler: Carly]] or [[spoiler: Doug]] ending up [[EatenAlive horribly devoured]]. The second episode features [[spoiler: Mark]] being used as a food source by cannibals and [[CruelAndUnusualDeath eventually succumbing to his wounds]]. The third episode kills off [[spoiler: Carly or Doug, depending on who survived]] in the most [[PlayerPunch sudden and upsetting way imaginable]] ([[TearJerker made more depressing]] if the Lee and [[spoiler: Carley]] [[ShipSinking relationship had been built up]]), and both [[spoiler: Duck and Katjaa]] in one fell swoop. By the end of the third episode, [[DwindlingParty the body count]] and the [[DividedWeFall amount of trust issues plaguing what's left of the original group]] will leave both the player and Lee ''seriously'' emotionally drained.
* While a few characters in the ''VideoGame/{{Warcraft}}'' series have cheated death such as Medivh, many others have been Killed Off for Real. King Llane, Blackhand, Gul'dan, Anduin Lothar, Ogrim Doomhammer, King Terenas, Uther the Lightbringer, Grom Hellscream, Tichondrius, Mannoroth, and Archimonde from the RTS games have all died in ways to show that they likely won't be coming back, even with all the resurrection and necromancy present in the series. Llane had his heart ripped out, Blackhand had his head cut off, Gul'dan was torn apart by demons, Lothar and Doomhammer both died on the battlefield (not the same battle), Terenas and Uther were both slain by Arthas with Frostmourne, Hellscream died in a HeroicSacrifice, Tichondrius was(presumably though he ''is'' a Dread Lord) permanently killed by Illidan after Illidan absorbed the Skull of Gul'dan's power, Mannoroth was killed by Hellscream's aforementioned HeroicSacrifice (and his ''skeleton'' has been made into a memorial dedicated to Hellscream), and Archimonde was ''disintegrated'' by the released power of the World Tree. And that's not even covering the characters permanently killed by the players in ''VideoGame/WorldOfWarcraft''. Although Gul'dan's soul "lived on" within his skull.
** In the Wrathgate event of ''VideoGame/WorldOfWarcraft'''s Wrath of the Lich King expansion, Highlord Bolvar Fordragon and Dranosh Saurfang are killed off for real. With Wrath's new "phasing" technology it's now possible to kill [=NPCs=] off for real for any individual player by changing the way they interact with the game world. This happens to a number of [=NPCs=] in several quest lines, after which they are never encountered again by that player and other [=NPCs=] will refer to them in the past tense. (Although they can still be not-yet-killed from another player's perspective.)
*** A later patch revealed neither were actually Killed Off for Real. Saurfang returns as a TragicMonster boss, Deathbringer Saurfang, in the Lich King's dungeon, and while we have yet to see Bolvar, he appears to be suffering a FateWorseThanDeath at the hands of the Lich King.
** As of Cataclysm, still ''more'' {{N|onPlayerCharacter}}PCs have been Killed Off for Real. The one most likely to hit home? The Grimtotem clan took advantage of a duel to assassinate [[BadassGrandpa Cairne]] [[ALoadOfBull Bloodhoof]] and try to pin it on [[CreatorsPet Garrosh Hellscream]].
*** Not just that, but Cho'Gall, a Warcraft II character of the Orc side, was finally killed off by players in the Bastion of Twilight.
*** Nefarian and Onyxia have a BackFromtheDead moment in BlackWing Descent. But in the end, both fell for good by players.
*** Ragnaros averts this in Firelands Normal mode, but in Heroic, players are aided by Cenarius, Malfurion Stormrage and Hamuul Runetotem to finally deliver this trope to one of the most well-known World of Warcraft lore villains.
*** The Hour of Twilight dungeon reveals Archbishop Benedictus' FaceHeelTurn as the new leader of the Twilight's Hammer, forcing players(Regardless if they're Alliance or Horde) to kill him.
*** After being a Warcraft 2: Beyond the Dark Portal Unit for members of the Horde, and after the terror he caused in the Cataclysm, Neltharion the Earth-Warder, AKA Deathwing, is brought to an end by players in the Dragon Soul Raid.
** Mists of Pandaria does have its own share of Deaths.
*** Subverted with Gara'jal the Spiritbinder. To him, DeathIsASlapOnTheWrist. He would later return to assist his Zandalari brothers and sisters in defending the Throne of Thunder from the Alliance and the Horde. Sadly, said brothers and sisters bite the big one.
*** The Grand Emperess Shek'zeer fell to the Sha before the arrival of the Alliance and the Horde. It takes a team of 10/25 heroes to bring her down.
*** Lei Shen winds up getting a Backfromthedead moment in Kun Lai Summit. But it is at the Pinnacle of Storms at the Throne of Thunder in which you bring down the tyrant, rip out his heart and make sure he never comes back again.
** The Siege of Orgrimmar brings among the death of many characters, including, but not limited to...
*** [[spoiler: Rook Stonetoe, He Softfood and Sun Tenderheart]]
*** [[spoiler:General Nazgrim. For many Horde players, this will be the ultimate Tear Jerker: Having to kill your Horde commander in Pandaria.]]
*** [[spoiler:Malkorok]]
*** [[spoiler:The Klaxxi]]
*** And finally, [[spoiler:The Old God Y'Shaarj after having his heart and soul converted to armor by Garrosh Hellscream(who gets arrested by Taran Zhu after losing) in the final battle in the Siege of Orgrimmar]]
* In ''VideoGame/TheWorldEndsWithYou'', all the Players are already dead and are playing the Reaper's Game to win another chance at life. However, Players erased by the Noise are killed off permanently and their entry fee is lost forever. Notable victims of Erasure include Rhyme in the first week (she recovers though), Sota and Nao in the second (as well as that Reaper)) and all three Game Masters (Sho also gets recovers) as well as Megumi.
* The Flash-based platformer ''You Only Live Once'' is ExactlyWhatItSaysOnTheTin. If you die once, it's game over. Try to continue, and you'll just get several cutscenes showing your girlfriend finding your body, calling an ambulance, a news report of your death, etc. Keep reloading the game and it'll just end up showing your grave. You ''can't play again''. (unless you delete two save files from your computer).
* Most every Roguelike game has this in effect for the player; dying deletes the save for the character, meaning any player death is permanent. Often times in these there are randomized dungeons involved that can very easily lead to player death for something small or impossible to see coming, like a very powerful creature showing up well before the player is ready, or a trap destroying critical pieces of the player's equipment. Slightly subverted in those that have an item (Amulet of Life-Saving in ADOM) that will resurrect the player immediately after death (usually breaking to avoid invulnerability).