* In ''Roleplay/TheGamersAlliance'', [[TheAtoner Omaroch]] and [[WanderingMinstrel Delora]] are a demon and a human who fall in love although such union is seen by many as blasphemy. The Land of the Living witnesses several intermarriages between different races, including elves, humans and dwarves among others, which result in children with mixed ancestry such as half-elves. Interspecies romance becomes a major plot point with [[NatureSpirit nymphs]] who need males from other races to breed because a magical curse makes them only give birth to female nymphs; this causes them to have no males of their own to keep their population going so they need to seduce men from other races in order to become pregnant and stop the nymph race from becoming extinct.
* Carmilla and all her more-or-less human entourage, in the WhateleyUniverse. In fact, with a major-league lust demon for a father and a [[HalfHumanHybrid human/Deep One hybrid]] mother, Carmilla is also the ''result'' of one of those...and from what we've seen of her dad since he showed up in the stories, which basically paint him as a devilishly charming rake with some trouble keeping his tentacles to himself who honestly dotes on his only daughter, romance may well have actually figured into it.
** Aside from the above, we've also seen hints at possible romance between one or two of the students and members of the local tribe of lycanthropes, and of course there are plenty of mutants whose mutations have forced them into more or less inhuman forms with little hope of reprieve. (The technical term is [=GSD=], for 'gross structural dystrophy'.) While the latter may still be technically and legally human, speculations about their potential present or future love-life (such as the Fury Twins idly musing on their chances of finding a boyfriend) necessarily do invoke this trope.
* The most prominent example from ''Roleplay/{{AJCO}}'' is Clovis/Mei - the former being a PlantPerson and the latter being an anthropomorphic zombie dog. ItMakesSenseInContext.
** Egg and Kube's relationship probably qualifies, though it's not quite as obviously romantic as the above.
** While it's unconfirmed and seemingly one-sided Kaja and Crez also come under this trope - Kaja is a bizarre Angel and Crez is... Crez.
* The art of Fredrik K. T. Andersson does this a lot, with plenty of hybrids, half-human or otherwise, resulting. [[ExtremeOmnisexual The Bard]] is the most infamous, having bred with a dragon, a werewolf, a minotaur, a naga, a scorpion woman, a centaur, a ''rock'' and possibly some more. The rock case is [[LampshadeHanging lampshaded]]. [[http://andersson.elfwood.com/Family-Gathering.2524339.html Here]] are six of his girlfriends with children (NSFW for scorpion breasts).
* ''{{Neopets}}, '''full stop'''''. It seems that any species of Neopet can breed with any other, leading to what can best be described as 'unusual' family combinations...To the point where a simple family of four ''could all be different species''.
* WebVideo/TheNostalgiaChick talked about how this was a bad idea in her "Science going wrong" video. "Don't put your dick in it!"
** But she also says “beauty soothes the savage beast,” if you’re female, you should let the creature put its dick in you.
* Unten & Thorn from {{Fantendo}} lore.
* Anything and everything produced by the FurryFandom.
** Case in point, the ChakonaSpace setting, hardly anybody is in a same-species romance, and most of the ones that are have [[{{Polyamory}} a little extra interspecies thing going on on the side.]].
* In {{Roleplay/Disney World of War}} there are several and the most prominant are Scatani, Scamp (dog) and Vitani (lioness) and Berlielle, Berlioz (cat) and Danielle (dog).
* Someone keeping track from ''Literature/{{Elcenia}}'''s Rhysel's point of view would assume this was the norm on Elcenia. Though it isn't entirely, it is assumed that a dragon will go through a number of non-dragon mates before settling down with a dragon--dragons live a ''long'' time.
* Literature/TheJournalEntries are practically MADE of this trope. There are VERY few ongoing relationships in which all people are the same species.
* Has happened sometimes in Roleplay/WeAreAllPokemonTrainers. At some point there are romances between humans and ''Legendaries'', such as Luke with Reshiram and Jane with Zekrom. (Both ended up breaking up though.) In a later case, [[spoiler:Sierra's boyfriend Vyvyan is {{baleful polymorph}}'d into a Rayquaza]].
* The website of the Neocene Project includes a creature that is the result of hybridization of coyotes, domestic dogs, and jackals ([[FridgeLogic hybridization between three species?]])
** Hybridization of coyotes, wolves, and domestic dogs is TruthInTelevision. At least one population of coyotes was [[RealityIsUnrealistic found by researchers to be genetically mostly wolf]].
* Foul Bachelorette Frog is a red-eyed tree frog, and Foul Bachelor Frog is an American bullfrog. Two very different kinds of frogs that don't even live in the same part of the world, and so would never even ''see'' each other, much less mate. But the two memes have been combined into "Foul Frog Couple."
* Happens in ''Theatre/TheLeagueOfSTEAM'''s "Tall Tails" (with a mermaid)... albeit briefly.
* [[OurElvesAreBetter Enoriel]] is revealed in later episodes of ''AudioPlay/RefletsDAcide'' to have had a romance with [[OurDragonsAreDifferent Alia-Aenor]], though she was posing in a human form when they met. As soon as he learnt what species she really was, he ran away out of fear.
* ''Website/ChatoyantCollege'': [[spoiler: Edie and Leila]] and [[spoiler: Dawn's Aunt Pru and Tom]].
* ''[[DNAKPTS4TV Death Note: The Abridged Series (Kpts4tv)]]'': along with the ''canon'' ship of Rem/Misa this series also gives us the Shinigami Ryuk as the resident MemeticMolester who's gone after Light, Misa, Matsuda, and [[CargoShip an apple]]. Later ''Souichiro'' hits on Ryuk when he mistakes him for a Goth chick.
-->'''Ryuk (to Light)''': [[BedmateReveal So... You want to talk about it?]]
* The pony BrainInAJar of ''Blog/AskBrainyTwilight'' is in a relationship with Carapace the changeling of the ''ReadingRainbowverse,'' taking this trope and multiplying it exponentially.
* Averted in Aelan mythology from WebOriginal/UstalNaror islands through existence of many more or less similar races.