%%%
%%
%% This page has been alphabetized. Please add new examples in the correct order. Thanks!
%%
%%%
%%
%% Image selected via crowner in the Image Suggestion thread: https://tvtropes.org/pmwiki/crowner.php?crowner_id=pv1atswd
%% https://tvtropes.org/pmwiki/posts.php?discussion=1452266899092104700
%% Please don't change or remove without starting a new thread.
%%
[[quoteright:350:[[VideoGame/{{Octodad}} https://static.tvtropes.org/pmwiki/pub/images/octodadromance.png]]]]
%%
----
Examples of InterspeciesRomance in VideoGames.
----

* ''VideoGame/AgarestSenki'' has five different human/non-human matchups across the four generations, and the fifth generation can choose one of the girls not chosen in a past generation. As said romances consist of a Syrium (an elf-like race), a neocollom ([[AsianFoxSpirit kitsune]]) with god's blood on her mother's side of the family, two elven hybrid sisters (half High Elf, half Dark Elf), and a Harpuia (angel-like WingedHumanoid), this isn't as improbable as it may sound. There's also teasings of a homosexual version; the hermaphroditic god Deeth flirts with Dyshana in female form and gets hit on by Thoma after she mentions she should have shown up in male form. Both Dyshana and Thoma are human.
* ''Videogame/{{Albion}}'' features a planet inhabited by both humans and vaguely [[CatFolk catlike]] HumanoidAliens called Iskai. When the deaf-mute human druid Mellthas first encounters Iskai, he curiously touches the semi-telepathic forehead organ of the female Iskai Sira. They form a PsychicLink and exchange so much in a short moment that they fall in love instantly.
* ''VideoGame/AnimalRestaurant'': In the terrace movie "Pink Breeze", Student Samoyed (a dog) confesses to Dori (a cat) that she likes him.
* ''VideoGame/ArTonelicoMelodyOfElemia'': a part-RPG, part-dating sim whose dating sim aspects revolve entirely around relationships between humans and Reyvateils - an all-female race of magical girls whose ancestors were artificial intelligences created from scratch using alchemy. You can also date said at least one of said ancestors, who's immortal and still around.
* In ''VideoGame/{{Arfenhouse}} 3'', Housemaster (who is an [[AnthropomorphicFood anthropomorphic piece of bread]]) and Evil Kitty fall in love, have GRatedSex together, and finally get married.
* In ''Videogame/{{Arknights}}'', there are instances of this happening in the background between the various Ancient races, and the offspring of such pairings are usually one race or another rather than any kind of hybrid. A couple of notable examples:
** In the ''Guide Ahead'' story, Cecilia is the child of [[OurDemonsAreDifferent a Sarkaz]] and [[OurAngelsAreDifferent a Sankta]], who were very unusual parents because normally [[FantasticRacism the two races virulently hate one another]]. Cecilia is also a very usual case because normally Sankta children are not born from a [=Sankta/non-Sankta=] pairing.
** In ''Who Is Real'', it is eventually revealed that Dawn (a Feline) was in a RescueRomance with Dusk (a [[spoiler: Feranmut, born from the remnants of a broken dragon deity]]), which effectively also turns it into [[spoiler: a DivineDate]].
** While they don't openly follow up on the relationship, [[PlayerCharacter the Doctor]] has a number of their Operators fawning over them and openly attracted to them, despite the Doctor not being of any race known on Terra. These include Ambriel (one of the aforementioned Sankta), Platinum (a Kuranta, or horse-folk), Warfarin (a Vampire Sarkaz), and Skadi (an Aegir, or fish-folk). Skadi is a particularly notable example, because her AlternateTimeline version, Skadi the Corrupting Heart, is even more enamored with the Doctor and is [[spoiler: a vessel for [[EldritchAbomination Isharmla, a Seaborn goddess]] who brings about the end of the world in that timeline.]]
* ''VideoGame/BlazBlue'' gives us [[HotWitch Konoe 'Nine' Mercury]] and [[RetiredBadass Jubei]], members of the Six Heroes who defeated the Black Beast prior to the series' events. The former is a human who has passed down her peerless knowledge of magic to the rest of the world, while the latter is a feline beastkin and said to be 'the Strongest Creature Alive'. Eventually, they conceived their child [[MadScientist Kokonoe]], who inherits traits from both of them, namely Nine's temperament, hair and eye colors and Jubei's feline attributes such as a two-forked tail.
* Elvis of the heroes of ''VideoGame/BravelyDefault2'' grows fond and eventually confesses his feelings to [[spoiler: Adelle, who is a fairy and reciprocates him]].
* ''Franchise/BreathOfFire'', as more or less the UsefulNotes/FurryFandom in video game format, is full of examples.
** ''VideoGame/BreathOfFireI'' features the neighboring villages of Tantar and Tuntar, one of which is populated entirely by humans and the other is populated entirely by the "forest clan," people who look like [[http://bof.wikia.com/wiki/Image:Gilliam.jpg this]]. The two villages get along incredibly well, and in fact, when the player first arrives, both are celebrating the fact that the first forest clan/human marriage is about to take place. And it ''does'', though you have to do a bit of a FetchQuest to save both villages from an imminent threat before the actual wedding. (Forest clan male/human female, if anyone was curious.)
** A cutscene in ''VideoGame/BreathOfFireII'' retroactively reveals that [[spoiler:Ryu (dragon clan) and Nina (bird clan) from ''Breath of Fire I'' got together, and the current bird clan as of ''Breath of Fire II'' is weaker due to being less pure-blooded due to being descended from that pairing]]. That's why the bird clan in Breath of Fire II can't shapeshift without a special irreversible ritual, whereas they could go back and forth at will in ''Breath of Fire I''. Much less extreme than the first example, since the clans in question are both basically human with some magical traits added.
*** The Bird Clan seems to love the species so much, that, by the time of ''Breath of Fire III'', the entire clan have essentially lost their wings, becoming boring old humans. Making the hero and heroine of every ''Breath of Fire'' game Ryu of the Dragon Clan and Nina of the Bird Clan doesn't help matters either.
** Also in ''Breath of Fire II'', both that generation's Nina (a [[WingedHumanoid winged human]]), and Katt (a half-furry {{catgirl}}) develop crushes for Ryu. Ryu's friend Bow (an anthropomorphic bulldog) has a thing for Nina's sister Mina (also a winged human). Sten (a monkey man) tries to blackmail Nina (and later Katt) into a date. And hell, even Ryu's own parents are an interspecies couple (a human and a dragon).
** Rand's mother Daisy in ''Breath of Fire II'' is of...somewhat debatable race, looking more or less like a human, though slightly larger. Whatever she is, though, she looks absolutely ''nothing'' like her very obviously armadillo son, which raises certain questions about his unseen father. Although, to be fair, the female representatives of some races (including Rand's race) tend to look much more human than the males.
** ''VideoGame/BreathOfFireIII'' teases SlapSlapKiss-style UnresolvedSexualTension between Momo (technically a dog, though the degree of anthropomorphism is so far toward human and the ears look so much more rabbit-like than dog-like that she more like a bunny-girl than anything else) and Rei (weretiger) from time to time.
** Bleu/Deis, a somewhat perverted lamia-like snakewoman, who hits on the different Ryus throughout the entire series.
* In ''VideoGame/BrutalLegend'', this is how [[spoiler:Eddie came to be. Demon Emperor Succoria and her human slave-turned-assassin-turned-lover settled down in the future after Succoria realized that demons would lose control of the world and humans would come to rule the Brutal Land, and she had a Villainous BSOD]].
* It's a bit of a spoiler for this example to be here, but here goes: ''VideoGame/{{Catherine}}'' can potentially end with this trope, [[spoiler:with the human protagonist Vincent and the succubus Catherine hooking up]]. Subverted in another ending with the same pairing [[spoiler:since Vincent becomes a demon too]].
* ''VideoGame/CaveStory'' can have [[RidiculouslyHumanRobots Quote]] or [[RobotGirl Curly]] [[OptionalSexualEncounter spend the night]] with Chaco, a [[MixAndMatchCritters Mimiga]].
* ''VideoGame/ChickenPolice:'' Several examples.
** Natasha Catzenko and her gangster lover Ibn Wessler: cat woman and rat man.
** Doctor Bubo and Ursula Fragaria: owl man and bear woman.
** Marty and Laura: chicken man and wolf woman.
** Sonny and Molly: chicken man and lovebird woman.
* In ''VideoGame/ChicoryAColorfulTale'', Pizza's parents are a dog (mother) and a raccoon (father). [[spoiler:Later, you end up playing a role in getting Beans, a female cat, and Pepper, a female skunk, to start dating]].
* ''Corruption of Champions'', its sister games ''Trials in Tainted Space'' and ''Fall of Eden'', and its spin-off sequel ''Corruption of Champions 2'', are all about this. And by romance we mean porking any enemy you beat if your lust meter is high enough, and even then many [[NonPlayerCharacter NPCs]] are open to sex up to and including a [[AttackOfThe50FootWhatever giant turtle woman]] who lives in a lake. To be fair though, you can romance companions and lovers if you feel inclined too.
* ''VideoGame/{{Darkstalkers}}'' loves to ShipTease between Felicia (a catwoman) and Jon Talbain (a werewolf). There's also one between Morrigan (a succubus) and Demitri (a vampire).
* ''VideoGame/DevilMayCry'' has Sparda, a devil, take on a human bride, Eva, begetting Dante and Vergil in the background stories. Sparda and Eva remain in the AlternateContinuity ''VideoGame/DMCDevilMayCry'', only Eva is changed from being human to being an angel.
* ''VideoGame/{{Diablo}}'': It turns out that the world was created by renegade angels and demons who wanted to [[HeavenVersusHell stop fighting]]. Their interspecies kids are the humans that make up the Player Characters. The project flopped horribly, with most of the renegades slaughtered by their insane leaders / punished by both heaven and hell, which is why you never see any renegade demons throughout your entire slaughterfest.
* ''Videogame/DivinityOriginalSinII'': The PlayerCharacter can pursue a romance with any of their companions, which can be any combination of a human, an elf, a dwarf, a LizardFolk, or an [[BoyMeetsGhoul undead]] {{Precursor|s}}. This passes largely without comment.
* Diddy and Dixie Kong from ''VideoGame/DonkeyKongCountry'', not that obvious though: Diddy has a tail which makes him a New World Monkey, while his girlfriend, Dixie, is a chimpanzee.
* ''Franchise/DragonAge'':
** In ''VideoGame/DragonAgeOrigins'', none of the party members with whom you can pursue a romance (consisting of three humans and a male elf) care what race the player character is, be he or she a human, elf, or dwarf. If a dwarf, the only option is an interspecies romance, and the romantic interlude is about as awkward as one might expect.
** In the expansion pack ''VideoGame/DragonAgeOriginsAwakening'', there is a heavy flirtation between Nathaniel Howe (human) and Velanna (elf).
** ''VideoGame/DragonAgeII'':
*** The player character, Hawke, is always human. Two of the potential love interests, Fenris and Merril, are elves. Neither particularly mind despite the setting's use of EnslavedElves. Of course, as a hunted former slave himself, Fenris has bigger things to worry about than social taboos, while Merrill seems to decide that the Dalish disapprove of her choices ''anyway'', so what's one more broken rule?
*** Isabela admits to having slept with humans, elves, and a "[[MythologyGag dwarf in drag]] once", but doesn't recommend the last one. She has a history with Zevran established in the first game and becomes FriendsWithBenefits with Fenris if neither of them are romanced.
*** While no romance occurs, Merrill once admits to finding [[ScaryDogmaticAliens the Qunari]] particularly "[[WalkingShirtlessScene easy on]] [[EatingTheEyeCandy the eyes]]". If Carver is alive, he has a crush on her, of which she may or may not be aware. If Carver isn't alive, ShipTease exists between his twin sister Bethany and Varric, who is a dwarf; YMMV on how serious it is.
*** A series of quests relates to a side character named Feynriel, who is the son of an elf woman and a human man. That particular Interspecies Romance was not especially happy, however.
** ''VideoGame/DragonAgeInquisition'':
*** The game brings back the ability to choose the player character's race, resulting in all the same race combinations as the first game, with Tal-Vashoth / Qunari added to the mix. As in ''Origins'', if playing as a dwarf, this is the only option available for a romance (unless you count flirting with Scout Harding); it's also the only romance option available to a male elf. Solas (an elf) is the only love interest to exclusively date within his own species.
*** If neither is romanced by the Inquisitor, it's possible for [[spoiler:Dorian (human) and the Iron Bull (Qunari)]] to end up together.
*** If the Inquisitor does not romance Sera (elf), she ends up with the Inquisition's arcanist Dagna (dwarf).
*** ''Inquisition'' also potentially allows the Inquisitor to reunite estranged lovers Briala (elf) and Empress Celene (human).
** The tie-in novels reveal that King Maric (human) had love affairs with two different elf women, Katriel and Fiona. [[spoiler:The latter relationship resulted in the birth of Alistair, one of the potential love interests in ''Origins''.]]
** The tie-in comics reveal that Maevaris Tilani (human) is the widow of Thorold Tethras (dwarf), Varric's cousin.
* ''VideoGame/DragonNest'' has one [[spoiler:between a human and an elf. Sadly, the human dies, and there's a string of sidequests about it]].
* This is deconstructed ''horribly'' in ''VideoGame/DragonQuestXI''. Because a man named Kainoa fell in love with a mermaid named Michelle, who lives for hundreds of years, it ends with [[SurprisinglyRealisticOutcome Michelle outliving Kainoa]], and [[TearJerker Kainoa and Michelle living the rest of their lives in depression and denial]]. When Michelle finally comes to terms with the fact that Kainoa died long ago, she commits suicide while thanking the hero and Kainui (Kainoa's grandson) for helping her come to terms with it all.
* The closest thing to a healthy romance in the first ''VideoGame/{{Drakengard}}'' game is the bond that develops between Caim (AxCrazy human) and Angelus (dragon). In the sequel they get to be [[spoiler:TogetherInDeath]].
* ''VideoGame/EarthwormJim'', whose name speaks for itself, has a huge crush on Princess What's-Her-Name, who is a humanoid insect. On the other hand, if [[ItMakesSenseInContext they're really all cows]] then this trope is averted.
* ''VideoGame/EasternExorcist'' have the second half of Xiahou-xue's campaign. She's a [[HalfHumanHybrid half-human]], half-''hulijing'', and a human scholar named Chen You-qing had fallen for her. After several missions she finally accepts and reciprocates his love, and the final cutscene upon completing the game sees Xiahou-xue and Chen You-qing travelling the world together.
* ''Franchise/TheElderScrolls'':
** Each game starting with ''Morrowind'' features an in-game semi-pornographic play titled ''The Lusty Argonian Maid''. In it, the main character, an Imperial (human) named "[[HerCodeNameWasMarySue Crantus Colto]]", is looking to get his "spear polished" by the titular Argonian (LizardFolk) maid. ''Skyrim'' introduces a sequel.
** Another in-game book introduced in ''[[VideoGame/TheElderScrollsIIDaggerfall Daggerfall]]'', ''The Real Barenziah'', tells the story of the future queen of Morrowind and Wayrest, Barenziah. In it, she (a Dunmer, aka "[[OurElvesAreDifferent Dark Elf]]") has sex with a Khajiit (CatFolk) named Therris so that he will induct her into the ThievesGuild. (As is the case with real life felines, Khajiit males have sharp spines on their penises, as Barenziah finds out the hard way.) Later, Barenziah has an affair with the human Emperor Tiber Septim, and becomes pregnant by him. (As a bastard child with a Dunmer mistress would be very inconvenient for the Emperor, he orders Barenziah [[GoodGirlsAvoidAbortion to have a magical abortion]].) The books are also in ''Morrowind'' and ''Oblivion'', although the version present in both is censored.
** The book ''The Last Scabbard of Akrash'' provides another Dunmer/Khajiit example, though it is less detailed about the actual act.
** When walking around the city of Stormhold in Shadowfen in ''[[VideoGame/TheElderScrollsOnline The Elder Scrolls Online]]'', your character may be accosted by an excited Dark Elf man who is telling everyone "I'm going to be an uncle!", something which obviously delights him. If you speak with him, you find out he has only one problem: His brother's wife is an Argonian (LizardFolk), so the child is Argonian and he can't pronounce its name properly. He's philosophical about it, though, remarking, "I'll just have to go with Junior."
** A book found in the ''Shivering Isles'' DLC to ''[[VideoGame/TheElderScrollSIVOblivion Oblivion]]'', ''Vitharn: The Fall'', states that the lord of Vitharn, a human, married an Argonian (LizardFolk) woman and they had a son together.
** The in-game book ''Notes on Racial Phylogeny'' discusses this trope from a scholarly perspective. It is stated that each race of Men (Imperial, Breton, Redguard, Nord) and Mer ("Elves" - Altmer, Dunmer, Bosmer) can indeed interbreed, with the race of the offspring being virtually identical to the mother (averting AllGenesAreCoDominant) with a few of the father's traits potentially sprinkled in. For example, if an [[SquishyWizard Altmer father]] and [[HornyVikings Nord mother]] produce a child, it wouldn't be a MagicKnight combination of each race. Instead, the child would be almost entirely Nord with the potential of having slight points to his ears or a slightly different skin tone. Over ''very'' many generations, however, this can result in offspring closer to [[HalfHumanHybrid Half-Human Hybrids]]. This is how the Bretons got their start as a race, with their (human) ancestors being {{Breeding Slave}}s to the Direnni Altmer of High Rock. Further, it notes that although there are ''tales'' of human or elf having children with the other races, there are no ''confirmed'' reports. (''[[VideoGame/TheElderScrollSIVOblivion Oblivion]]'' confirms via first-hand evidence that at least [[OurOrcsAreDifferent Orcs]], who are the Orsimer, or "Changed Elves", can have children with humans (and presumably other elves). [[spoiler: As can Cyrodiil-style vampires.]]
** In the {{backstory}}, the Tsaesci, a race supposedly made up of "[[SnakePeople snake vampires]]" hailing from [[{{Wutai}} Akavir]] who once invaded Tamriel, supposedly left behind offspring with the Tamrielic races who are considered "beautiful, if frightening." (Other sources indicate that the Tsaesci are men little different from those in Tamriel, downplaying the trope if true.)
** Also from the backstory, St. Alessia, the Slave Queen who overthrew the Ayleids ("Wild Elves") to found the first Cyrodiilic Empire of Men, was [[DivineDate romantically involved]] with Morihaus, an [[OurGodsAreDifferent et'Ada]] who took on the form of a great humanoid, winged bull. They eventually gave birth to what would become [[OurMinotaursAreDifferent the Minotaur race]].
** In the [[SaintlyChurch religion of the Nine Divines]], Mara, the LoveGoddess of the Nine Divines (with a focus on commitment, family, fertility, and matrimony compared to Dibella's (another Divine) focus on the carnal and sexual aspects of love) does not place any restrictions on marriage within the religion of the Nine Divines; thus all may marry, irrespective of gender and race, and unite their souls in the holy union.
** ''[[VideoGame/TheElderScrollsIIIMorrowind Morrowind]]'':
*** A RomanceSidequest available for any male character in ''Morrowind'' is a Khajiit woman. She's not picky, of course.
*** One side quest involves finding a Dunmer thief who stole a Breton noblewoman's jewellery. It turns out that she's not actually too concerned about the jewellery, [[LoveAtFirstSight but the thief himself]]. Finding this man reveals that her love is, in fact, requited.
*** A quest that is part of both the Thieves Guild and Fighters Guild quest lines tasks you with gaining the support of Hrundi, a Nord man who was the NumberTwo to the ReasonableAuthorityFigure former Guild Master before the current (very corrupt) Guild Master took over. You can learn that he has taken on a Dunmer lover, and can {{Blackmail}} him with that fact for his support. (The "interspecies" part itself isn't the reason for the blackmail, rather, it's because this information puts his lover in danger if the corrupt Guild Master finds out about her.)
** ''[[VideoGame/TheElderScrollsVSkyrim Skyrim]]'':
*** You can marry any marriageable character, regardless of race or [[EveryoneIsBi sex]], allowing you to be in an interspecies romance. The only races without a marriageable character are the Bosmer (Wood Elves) and Khajiit.
*** In the ''Dawnguard'' expansion, the player can flirt with Serana, a vampire, and can indicate romantic feelings for her, which she will reciprocate but won't allow to go farther than that. It's implied that she had [[RapeAsBackstory a very dark past involving the ritual that turned her into a vampire, as she had to "submit" to Molag Bal.]] She also has issues with marriage, since her parents (the only married couple she's ever known) had a pretty awful one, and isn't comfortable with entering a temple long enough to go through with the ceremony anyway.
%%(Administrivia/ExamplesAreNotGeneral)*** There are also several examples of [=NPCs=] who are in interspecies marriages - quite a few more than one might expect, given Skyrim's FantasticRacism.
* [[ChickMagnet The Duchess]] of ''VideoGame/EmbricOfWulfhammersCastle'' can romance a dark elf, and is lusted after by at least one dwarf.
* Your goal in ''VideoGame/EVOSearchForEden'' is to guide evolution so that you can eventually shack up with Gaia, the personification of the Earth itself. [[spoiler:This is also the goal of Bolbox, the main antagonist of the final era. Bolbox happens to be a heavily mutated algae cell who thinks he's a human]].
* ''Franchise/FateSeries'':
** ''VideoGame/FateExtra'': Servants are not human, so any of Hakuno Kishinami's romances count, especially with the LittleBitBeastly ones like Tamamo no Mae and Elizabeth Bathory.
** ''VideoGame/FateGrandOrder'':
*** The same principle, Ritsuka Fujimaru has romances with many Servants, and many of them do not look purely human.
*** Euryale and Asterios the Minotaur fall in love.
*** Sakamoto Ryōma's wife Oryō is a dragon who fell in love with him and took human form to be with him.
*** Surtr the Fire Giant fell in love with the human Ophelia Phamrsolone.
*** Yu Miaoyi is a vampire-like nature spirit who fell in love with the robot Xiang Yu, even when he's modified into a monstrous centaur-like sentinel.
*** Boggart, a lion-headed man, marries an amnesiac Mash Kyrielight, though he is unable to consumate the union because she is too strong for him.
* ''Franchise/FinalFantasy'':
** ''VideoGame/FinalFantasyIV'', [[spoiler:Cecil and Golbez]] were sired by Kluya, a Lunarian (that is, an alien from a very, ''very'' distant world, who eventually settled on a moon orbiting the game's planet,) from a human mother. [[spoiler:Cecil]] goes on to have children of his own, again with a human mother.
** ''VideoGame/FinalFantasyVI'', Terra is the daughter of [[{{Woolseyism}} Madonna]]/Madeline, a human girl, and Maduin, a satyr/Gigas Esper. She eventually gains the ability to [[SuperMode turn into an Esper-like humanoid herself]].
** ''VideoGame/FinalFantasyVII'', Aerith, [[LastOfHisKind the last Cetra]], is the daughter of a human scientist named Gast, and a Cetra woman named Ifalna. Of course, the Ancients are almost entirely human themselves, so there's really not much of an issue here, until [[MadScientist Hojo]] comes along and tries to mate Aerith with Red XIII, a huge talking wolf/lion that is another LastOfHisKind. There's no indication that Hojo's idea would have actually ''worked'', though. According to the Compilation, there ''was'' at least one more, female, member of Red XIII's race, who had been his mate before he was captured by Shinra.
** In ''VideoGame/FinalFantasyIX'', [[spoiler:Garnet and Eiko]] were Summoners, apparently a different species from normal people, since they were born with horns. Also, Zidane's not entirely human either -- obvious from the start since he has a ''tail'', but this turns out to be more than a cosmetic quirk. And then there was the Vivi/Quina marriage, which involved a techno-magical construct and an ambiguously gendered giant frog thing.
** In ''VideoGame/TheFinalFantasyLegend'', not only does this occur, but it's so common that [[UnusuallyUninterestingSight nobody bats an eyelash]] about King Armor (human, or close to it) falling in love with a girl that uses the same sprite as beholders and slimes!
** In ''VideoGame/FinalFantasyX'', villain [[DarkMessiah Seymour]] has ([[ParentalAbandonment or]] [[SelfMadeOrphan had]]) a Guado father and a human mother. [[MessianicArchetype Yuna]], as his {{Foil}}, is also the product of one of these; her father, Braska, was a human, while her mother was an Al Bhed. Yuna doesn't bring it up often because of [[FantasticRacism how the Al Bhed are treated in Spira]], but it's still visible due to her mismatched eyes.
** ''VideoGame/FinalFantasyXI'', being an MMO with five humanoid races and all, is bound to have plenty of romance, found both in the player base and story lore. The tragic romance between Raogrimm, a Galka, and Cornelia, a Hume, became the catalyst of war. The main character of Wings of the Goddess, Lilisette, is apparently the offspring of an Elvaan and a Hume, in a game where cross-breeds were never mentioned before. Also, one cannot deny the massive amounts of Tarutaru x Mithra doujin...
** ''VideoGame/FinalFantasyXII'':
*** There's a little [[ShipTease shipteasing]] between Fran and Balthier, particularly in the Pharos after [[spoiler: defeating Dr. Cid]]. ''Revenant Wings'' expands on this -- when Tomaj attempts to romance Fran, she tells him Balthier's methods were different.
*** There's also a sidequest in Rabanastre in which you can pair a Viera up with a Hume. The Hume tells the party that he wouldn't have imagined a Viera/Hume pairing could work until he saw Balthier and Fran.
** ''VideoGame/FinalFantasyXIV'', like ''Final Fantasy XI'', has five playable races and there are some [=NPCs=] that show interest in another person, regardless of their race. According to WordOfGod, there are actual pairings of different races, but they are usually hidden from public view due to different pairings generally being frowned upon in most societies. [[spoiler: There's also Shiva, an Elezen (humanoid elf) woman from Ishgard's ancient history, who had fallen deeply in love with a dragon, who reciprocated. It's rumored she [[HotSkittyOnWailordAction laid with him]], but whether this is true or just propaganda because she had taken the side of the dragons during the nation's first conflict with the dragon race is never clarified. The more alarming aspect is that he ended up ''eating'' her, ''consensually'', which joined her spirit to his and averted the MayDecemberRomance of a mortal Elezen falling in love with an immortal dragon. A thousand or so years later, her influence is the only thing stopping Hraesvelgr from joining the dragons’ eternal war against Ishgard. It is later explained that dragons pick soulmates purely based on their spiritual bond and love with their mate rather than based on sexual feelings. And dragons in fact reproduce asexually in any case. This may imply that Shiva and her dragon mate simply loved each other for what they were to each other.]]
*** Notably, an endgame quest to unlock a dungeon is explained by a gay male couple consisting of a Miq'ote and a Hyur. The dialogue states the two were forced out of their home village due to discrimination and lead one to assume it was due to being a homosexual relationship. [[BaitAndSwitch However]] they state shortly after it was due to their differing races and the fact that both of them are men is never even discussed.
*** It's also possible for the players to engage in this, as the Eternal Bond system allows two players purchase engagement bracelets on the cash shop which lets them embark on a quest with the reward of an in-game wedding and appropriate attire as well a wedding band that teleports the player to their spouse. (At least on the free tier. Higher paid levels offer more rewards) This is entirely unrestricted by race or gender.
** ''VideoGame/FinalFantasyCrystalChronicles'' has a half [[PlantPerson Lilty]]/Clavat princess (disguising herself as a half Lilty/Selkie, which seems to go unnoticed) in the first game.
** The Lilty princess from ''Crystal Bearers'' seemingly has a crush on the Layle, the crystal Clavat player character. Layle himself has further ShipTease with Belle (Selkie), Keiss (Selkie), and Amidatelion (a crystal Yuke), though in Ami's case she considers herself the same species as Layle in ''Dissidia Opera Omnia'' due to them both being crystals.
** ''VideoGame/DissidiaFinalFantasy'': The [[VideoGame/FinalFantasyI Warrior of Light]] and the goddess of harmony Cosmos seem to have a strong bond with each other. This bond is most prevalent in 012 as he nearly dies in order to protect her from a swarm of Manikins. One just might call it romantic. However, if they do have romantic feelings for one another, it is unknown whether or not either one and/or both of them are [[ObliviousToLove oblivious]] to it. [[spoiler:Then subverted when its discovered both are in fact the same species after all.]]
* ''Franchise/FireEmblem'':
** In ''VideoGame/FireEmblemMysteryOfTheEmblem'', Xane(A Divine Dragon in Human form) attitude towards Marth comes off as somewhat flirty.
** In ''VideoGame/FireEmblemTheBlazingBlade'', [[spoiler: Ninian the half-ice dragon]] is a possible mate for the human hero Eliwood. There's also [[spoiler:Nergal (human) and Aenir (ice dragon), the couple that spawned Ninian and her brother Nils]].
** InterspeciesRomance between Beorcs (HumansByAnyOtherName) and Laguz (humans who can [[{{Animorphism}} shapeshift into animals]]) is all over the place in ''Path of Radiance'' and ''Radiant Dawn''. In fact, some of these romances are either directly or indirectly responsible for most, if not all of the events in the two games. Though in this case it's somewhat {{justified|Trope}} as [[spoiler: Beorc and Laguz share a common ancestry]].
*** Romances between different types of Laguz [[DownplayedTrope could also count]], such as [[spoiler:the Raven Naesala and the Heron Leanne]] in ''Radiant Dawn''.
** In ''VideoGame/FireEmblemAwakening'', Nowi and Panne are potential wives for the majority of the male characters, and are of the [[OurDragonsAreDifferent Manakete]] and [[HairRaisingHare Taguel]] races, respectively. Tiki, reappearing from Mystery of the Emblem makes a reappearance where its said she had a crush on Marth in the past, she can also marry the PlayerCharacter.
*** In the second half of the game, should Nowi and Panne be married, the players will meet [[spoiler:Nowi's half-Manakete daughter Nah and Panne's half-Taguel son Yarne (specifically said in one of Panne's endings to have inherited almost all his genes from his mom). They can marry either their human companions from the second generation, or the PlayerCharacter. Any second generation marriage that involves PlayerCharacter's own exclusive child, Morgan, will also count if s/he is the produce of the player's own marriage with Panne, Nowi, Nah, Yarne, or Tiki]].
** In ''VideoGame/FireEmblemFates'', Kaden the [[AsianFoxSpirit Kitsune]] and Keaton the [[OurWerewolvesAreDifferent Wolfskin]] are potential husbands for most of the female characters, including a Female PlayerCharacter. Like in ''Awakening'', if Kaden and Keaton are married, [[spoiler:the players will be able to recruit their respective hybrid children, Selkie and Velouria, who themselves can marry most of the second generation males or a male PlayerCharacter.]]
*** The PlayerCharacter him/herself, who can transform into a dragon, is revealed to be [[spoiler:the produce of a relationship between the human Mikoto and the dragon Anankos]]. Additionally, [[spoiler:any romantic relationship involving his/her own exclusive child, Kana, will always count as this trope (for obvious reasons), though Kana's own degree of human ancestry can vary from 3/4 all the way down to 1/4 depending on who his/her other parent is. In the localization, the Kanas have more limited romantic options -- Female Kana can only date the human Kiragi (and maybe Siegbert, [[MaybeEverAfter when she grows up]]), while Male Kana will only hook up with the aforementioned Selkie (and maybe either Nina, Rhajat or Mitama, [[MaybeEverAfter again whe grows up]]).]]
*** Any romance involving the player character also counts, due to [[spoiler:their aforementioned [[HalfHumanHybrid half-dragon genes]]]].
** ''VideoGame/FireEmblemThreeHouses'' has three non-humans who can become romantically involved with other characters. In a twist, the non-human nature of all three is initially secret. They are [[spoiler: Rhea, Seteth, and Flayn, all of whom are Children of the Goddess (a near-extinct species of shape-shifting dragon demigods) that have taken up human identities]]. In addition, [[spoiler: Flayn herself is a product of one of these relationships, being the child of Seteth and a human woman]].
* In ''VideoGame/FridayNightFunkin'', Girlfriend, a demon, is in a committed relationship with Boyfriend, a human.
%%* ''VideoGame/GiantsCitizenKabuto'': Baz and Delphi [[https://www.youtube.com/watch?v=V_TNfjfQvto here]]
%%-->"We've got to help, Delphi. Yes, she may be different to us -- slightly taller and a different colour -- but I love her, you hear me, I love this woman!"
* ''VideoGame/{{Gish}}'' has the titular protagonist—a sentient ''ball of tar''—rescuing his human girlfriend, and in a good ending they get married. In the mobile phone port, they even have children.
* Ambiguous on whether or not it's truly interspecies, but in the ending of ''VideoGame/GoldenSunTheLostAge'', a couple of Mars Clan girls (scaly draconic AmazingTechnicolorPopulation) seem romantically interested in Felix, not to mention his ShipTease moments with Karst. In ''VideoGame/GoldenSunDarkDawn'' there's some ambiguous ShipTease between {{beast|Man}}girl Sveta and HeroicMime Matthew (and also some subtext between Sveta and [[LesYay Karis]]). This is to say nothing of ''VideoGame/GoldenSun'''s notorious {{Shipping}} fandom, who will readily pair up characters and sometimes even [[CargoShip inanimate objects]] that have [[ShipsThatPassInTheNight very little interaction]], [[FoeYayShipping purely antagonistic interaction]], or [[CrackPairing none at all]].
* Generally averted in ''VideoGame/GuildWars2,'' with WordOfGod pointing out that none of the five playable races (human, charr, norn, asura, or sylvari) can interbreed and a bout of extended ShipTease between Rox the charr and Braham the norn in Living World Season 1 being hastily undone with an insistence that they're "JustFriends". However there ''is'' finally a canonical interspecies couple introduced during a mission in the 'Path of Fire' expansion, where you meet a human called Nicholas and a norn called Ygnvild who have fallen in love with each other and decided to spend eternity together, [[spoiler:[[NotHyperbole literally]], since they're both dead and you meet them in [[AfterlifeAntechamber the Realm of the Lost]], where they've decided they'd rather stay instead of moving on to their respective afterlives and being separated]].
* ''VideoGame/GuiltyGear'' has the human Ky who married [[spoiler:Dizzy]] (a Gear). [[spoiler:Subverted come Xrd, when it turns out that Ky has become at least a partial Gear.]]
* ''VideoGame/HarvestMoon'':
** In ''VideoGame/HarvestMoonAnimalParade'', either gender of player character can choose a god or mage as their {{Love Interest|s}}. In the latter case, the Witch and Wizard don't seem ''particularly'' nonhuman, but there is at least one moment where the Witch makes a point of referring to the main character as a human.
** A better example is the Harvest Goddess and Harvest Lord in ''Animal Parade''. A Harvest Goddess is available for marriage in ''[[VideoGame/HarvestMoonFriendsOfMineralTown Mineral Town]]'', ''[[VideoGame/HarvestMoonDS DS]]'', and ''Hero of Leaf Valley''. Before ''Animal Parade'', what did female players get? A Kappa.
** ''VideoGame/HarvestMoonDS'' even added a mermaid for you to marry. Yes, a mermaid. You can "[[HideYourGays best friend]]" her in the Japanese version of ''Cute'', though [[HideYourLesbians not the English version]].
** ''VideoGame/StoryOfSeasonsTrioOfTowns'' adds a [[AsianFoxSpirit Kitsune]] named Inari. Inari's gender is the opposite of the player's, so they can marry either gender. Originally Inari was the only bachelor/bachelorette who you couldn't have children with, though an update added the option in.
* Among the romance options in ''VideoGame/AHouseOfManyDoors'' are a sentient murder of ten million crows and [[CargoShip an oil rig]]. Alternatively, ''any'' romance option has the potential to be this if you choose a nonhuman portrait during character creation. There's also an optional sidequest that involves helping a fish monster woo the river it used to live in.
* In ''VideoGame/HuniePop'', it's possible to romance [[OurFairiesAreDifferent Kyu]] under the right conditions. It's also possible to romance [[spoiler:an alien woman, a CatGirl and ''the Goddess of Love herself'']].
* In ''Videogame/IMissTheSunrise'', your options of crewmates to pursue romantically are not limited to species. You are free to play a human character who professes their love to LizardFolk, or vice versa.
* In the ''VideoGame/JakAndDaxter'' series, [[GeniusDitz Tess]] went from [[CutenessProximity finding Daxter adorable]] in ''Jak II'' to [[SickeninglySweethearts falling in love with him]] between then and ''Jak 3''. Thankfully, they don't actually ''do'' anything [[spoiler: until Tess is turned into an ottsel]].
* Ever play the classic arcade game ''VideoGame/{{Joust}}''? When you destroy one of the vulture riders, the vulture lays an egg that you must collect to complete the round. If it is allowed to hatch, an enemy human emerges, and a new flying steed comes in to pick him up. The question is, ''why does this happen?'' An explanation comes to mind...
* In ''[[HGame Kamidori Alchemy Meister]]'' one of the three main love interests is an elf. The main character is also known for ''getting along'' with all kinds of supernatural creatures, including elementals, angels, kitsune, succubus and more.
* One story event in ''VideoGame/KingOfTheCastle'' involves the Archduke of Saal's engagement to Prince Glorb of the Finfolk, a sapient amphibious species who live in the waters between the Kingdom and Saal. The King is invited to attend the wedding but can choose instead to sabotage it, which can involve sending the Chancellor to seduce Glorb (resulting in their marriage) or having the King do so themself (resulting in ''their'' marriage)!
* ''VisualNovel/IWaniHugThatGator'': The "Prehistoric Romance" is between Inco, the human man, and Olivia, the baryonyx woman. When the two of them go an arcade with Liz and Damien, the latter compares it to a double date. It is only after [[spoiler:Art Teacher Mr. Iadakan dies]] that the two consider themselves a couple.
* The implied pairing in ''VideoGame/{{Klonoa}}'' is between [[TheHero Klonoa]] (cat-rabbit looking creature) and his friend [[CuteClumsyGirl Lolo]] (a humanoid girl with a cat tail.)
* ''VideoGame/LeagueOfLegends'': Human Jarvan and half-dragon Shyvana are...''close'', put it that way, and Blitzcrank's dating service ships Rammus the Armordillo with a cactus (whether it's the one from ''VideoGame/PlantsVsZombies'' remains to be seen).
* ''Franchise/TheLegendOfZelda'':
** ''VideoGame/TheLegendOfZeldaALinkToThePast'''s instruction manual states that the [[OurElvesAreDifferent Hylians]] are an extinct race by this time, replaced with the rounded-ear Hyruleans. An excerpt from ''Hyrule Historia'' implies that this is the reason why (which also explains why the Sages' descendants all appear to be humanoid). However in ''VideoGame/TheLegendOfZeldaBreathOfTheWild'' Hylians seem to have supplanted ordinary humans somehow.
** ''VideoGame/TheLegendOfZeldaTheWindWaker'', a girl named Maggie asks you to deliver a love-letter to her love at the Forsaken Fortress. As it turns out, the person she met and fell in love with while being held captive there is actually a Moblin -- one who is torn between wanting to return the affection and wanting to eat her. In addition, Link gets hit on by the Queen of Fairies. He appears to actually quite like it.
** The ''VideoGame/TheLegendOfZeldaOracleGames'' have a good dose of this, too. In ''Seasons'', Link (Hylian) dates the Subrosian pop star Rosa (and, in the manga, draws the romantic attention of his pet chicken, Piyoko). In ''Ages'', Link gets propositioned by the ''Maku Tree'', and Queen Ambi pines for... the undead Piratian Captain. Then again, since he's been stuck in another world for years, he may have been human a long time ago.
** Link's AccidentalMarriage to [[OurMermaidsAreDifferent Princess Ruto]] in ''VideoGame/TheLegendOfZeldaOcarinaOfTime''. While she does let him off the hook due to the "Sage of Water/Hero of Time" thing, she really did want to go through with. Also, WordOfGod confirms that [[FairyCompanion Navi]] had fallen for Link [[ChickMagnet just like nearly every other girl in the game]].
** ''VideoGame/TheLegendOfZeldaTwilightPrincess'':
*** There's pretty blatant hinting at something between Link (Hylian) and Midna (Twili), [[spoiler:made tragic by the ending]]. The [[Manga/TheLegendOfZeldaTwilightPrincess2016 manga adaptation]] [[spoiler:throws the hints out the window and has the two [[AdaptationalRelationshipOverhaul openly showing affection]] for each other, turning the pair into StarCrossedLovers by the end]].
*** Link's childhood friend Ilia is also a heavily ImpliedLoveInterest and is a human, though it's difficult to tell if Hylians are really a separate species from humans or not (especially in this game, where Hylians are referred to as "human").
** A strange case in ''VideoGame/TheLegendOfZeldaSkywardSword'' where Scrapper, a reanimated robot, falls for Fi, the "spirit" of the Master Sword.
** In ''VideoGame/TheLegendOfZeldaBreathOfTheWild'', there is Mipha, a Zora, who has strong feelings for Link, a Hylian. She even made him a special set of armor, which is apparently a custom among the Zora for a princess to give to the man she intends to be her husband. There's also another female Zora, Finley, who wants a boyfriend and you can assist her in finding one. She ends up with a Hylian man and despite Finley's body not reaching adulthood yet (she's mentally an adult), the two seem to get along well. [[GenerationXerox Finley's mother]] was also in love with Link when she was younger.
** Gerudo are a OneGenderRace of women who find Hylian boyfriends in order to breed. In ''[[VideoGame/TheLegendOfZeldaBreathOfTheWild Breath of the Wild]]'', Several Gerudo [=NPCs=] mention looking for husbands, and there are even classes in Gerudo Town dedicated on how "voe" work and how to court them.
** The Zonai in ''VideoGame/TheLegendOfZeldaTearsOfTheKingdom'' were a race of [[BeastMan sheep-man]] {{precursors}} and it's revealed that one of them married Zelda's ancestor and founded/refounded the Kingdom of Hyrule.
* In ''VideoGame/{{Littlewood}},'' the Hero is never implied to be anything other than human. However, you can date a half-elf (Iris), a half-orc (Zana), a bird-person (Bubsy), or a cat person (Toby).
* Crow, the heroine's bird companion from ''VideoGame/TheLongestJourney'', claims he's made advances to female birds of multiple species, although it's not clear if his efforts were successful or if he's just making it up.
* In the ''VideoGame/{{Lunar}}'' series, it just happens to work out that all the beastfolk characters with romance arcs have human love interests.
** Jessica (a half-beastperson) and Kyle (a human) in ''VideoGame/LunarTheSilverStar''.
** Ronfar (a human) and Mauri (a beastperson) in ''VideoGame/LunarEternalBlue''.
** Senia (a beastperson) and Azu (human) in ''VideoGame/LunarWalkingSchool''.
* ''VideoGame/Macross30TheVoiceThatConnectsTheGalaxy'' has a love triangle between the male human protagonist, a female [[OurGiantsAreDifferent Zentraedi]], and a native Ouroboros girl.
* A strange example is found in ''VideoGame/MagnaCarta2'', where [[OurElvesAreDifferent Celestine]] falls in love with [[ProudWarriorRaceGuy Argo]] at first sight. Everyone but Celestine finds it all... Awkward since Argo's a massive creature who looks like a mix between a Dragon and a Hawk. He does eventually warm up to her however.
* In '' VideoGame/{{Mana Khemia|AlchemistsOfAlRevis}}'' one of the human [[spoiler: (sort of)]] protagonist's possible love interests is a [[CatGirl catfolk]] named Nikki, and if you manage to get her ending, not only do they get married, but they also have kids.
* ''Franchise/MassEffect'':
** [[http://masseffect.wikia.com/wiki/Asari Asari]] are an [[OneGenderRace all female species]] that reproduces by randomizing part of their DNA using that of any other species [[EveryoneIsBi regardless of gender]] as a template. Indeed they're ''encouraged'' to do this, and two asari having a daughter together gets [[FantasticRacism rather looked down upon]] in their society. Somewhat understandable, in that pureblood couples supposedly increase the chance of [[SuccubiAndIncubi Ardat-Yakshi]] being produced. Liara T'Soni was an asari romance option for both male and female Shepards from the very first game.
*** In ''VideoGame/MassEffect2'' there's another asari option with Morinth. The resulting sex scene lasts [[NonStandardGameOver six seconds because, as an Ardat-Yakshi, she has a rare genetic disease that kills anyone she mates with]]. Well, [[SchmuckBait you are warned]].
*** The Game Seller is overheard mentioning an asari/hanar porn game from a section of the Citadel.
*** [[CoolOldLady Matriarch Aethyta]] mentions past romantic relationships with a turian, [[HotSkittyOnWailordAction an elcor]], and a hanar. And her father was a krogan.
** ''VideoGame/MassEffect2'' has more aliens than humans with a RomanceSidequest; Thane and Garrus ([[http://masseffect.wikia.com/wiki/Drell drell]] and [[http://masseffect.wikia.com/wiki/Turian turian]], respectively) for female Shepard, and Tali ([[http://masseffect.wikia.com/wiki/Quarian quarian]]) for male Shepard, the two latter being [[FanPreferredCouple fan favorites]] returning from the first game.
** Joker and EDI in [[VideoGame/MassEffect3 the third game.]] Him being a human and her, an AI controlling a robot body.
** Mordin mentions in passing that he's gotten a surprising number of passes from other species... but then he's Mordin so that may not count. He also mentions that salarians like himself are considered as quite attractive by certain unlikely species.
*** He talks a lot about interspecies sex. He even [[https://www.youtube.com/watch?v=mAP92rvm1hQ gives you]] TheTalk of the... biological implications of such romance. He notes that chafing will result and recommends you not to *cough* ...ingest.
*** One time you visit him, he tells you he's currently busy with dealing with an outbreak of a sexually transmitted disease, that is only present in varren. "[[BestialityIsDepraved Implications unpleasant.]]"
** After completing a certain quest line on the krogan homeworld EDI will inform you that "We have received several breeding requests for Grunt... and one for Shepard".
---> '''Grunt:''' [[Funny/MassEffect2 Ha!]]
** There's a human magazine named ''Fornax'', which features asari, hanar, drell, quarian, batarian and volus models. It has a monthly production run of ''127 million'' and features '''five-sensory stimulation'''.
** [[EthicalSlut Yeoman Chambers]] makes no secret of her attraction to many alien species.
** A widely popular in-universe film called ''Fleet and Flotilla'' is about a turian and quarian pairing. This gets mentioned in ''Mass Effect 2'' by one unlucky-in-love turian. There is also a videogame. The kicker? [[spoiler:''Legion has played it.'' And he's ''terrible'' at it.]]
*** The ''Citadel DLC'' for ''3'' reveals that Tali apparently is a ''big'' fan of the musical version of ''Fleet and Flotilla''. It also reveals she borrowed some lines from the movie to give her the courage to admit her feelings for Shepard, in her romance arc in ''VideoGame/MassEffect2''.
** If Shepard doesn't romance either Garrus or Tali and both survive to ''VideoGame/MassEffect3'', they end up together. Both are apparently fans of ''Fleet and Flotilla'', humorously enough. Should a female Shepard romance Garrus, a drunken comment from Tali during the ''Citadel'' DLC indicates that she'd be perfectly happy with both of them at the same time.
** Turian-quarian romances are a bit of a thing, apparently, as they're biologically compatible, at least in terms of [[MirrorChemistry chirality]]. So there's less of a chance of one or both partners suffering a violent biochemical reaction in case of...''ingestion''.
** Curiously, interspecies couples became ''significantly'' more prevalent in background scenes as the series continues, especially in ''Mass Effect 3'', which has seemingly more of them than same-species ones. Such is [[LikeYouWereDying life during]] an AlienInvasion -- as Joker points out, people have a lot more to worry about than a little public disapproval.
** In the ''Citadel'' DLC, if you get a female Shepard drunk enough, and she's on good enough terms with him, [[spoiler: she and ''Javik'']] can have a one-nighter. Which they will ''[[LetUsNeverSpeakOfThisAgain never speak of again]].''
** In ''VideoGame/MassEffectAndromeda'' [[PlayerCharacter Pathfinder Ryder]] can romance several alien characters, including Peebee (asari), Vetra (turian) and Jaal (angara, a new species native to Andromeda), who are available to male and female Ryder. Both Ryders can also have a fling with asari reporter Keri T'Vessa, and male Ryder can also woo the angara Avela Kjar.
*** Several NPC[==]s and background characters are shown or implied to be in an InterspeciesRomance as well, such Sloane Kelly with her turian second-in-command Kaetus.
*** Peebee herself is the product of an asari-elcor couple, while fellow asari crewmate Lexi T'pero is the product of an asari-turian couple and has a thing for krogan.
*** In the krogan colony on Eledaan, there is mention of a ShowWithinAShow called ''[[Film/CantHardlyWait Krant Hardly Wait]]'', which is about a male krogan trying to romance a female human.
* ''VideoGame/MegaManZero4'' introduced two characters, Neige (human) and Craft ([[RidiculouslyHumanRobots Reploid]]). The latter even explicitly stated that he fell in love with her, and their romance is a very important turning point in the game!
** There are [[ShipTease tons of hints]] concerning Ciel's feelings for TheHero [[VideoGame/MegaManZero Zero]]. And [[AllThereInTheManual not just in the main medium]], in fact...
** In one of the games in the ''[[VideoGame/MegaManZero Zero]]'' series, there is an NPC that looks like an old man - despite being a ''Reploid''. Years ago he fell in love with a human girl and married her. As she grew older he had his appearance modified to match her age. [[TearJerker When she finally succumbed to old age, he chose to keep his elderly form as a way to remember her]].
* The whole point of the (in)famous ''[[http://monstergirlquest.wikia.com/wiki/MonsterGirlQuest_Wiki Monster Girl Quest]]'' by/from/of Japan.
* ''Franchise/MortalKombat'':
** [[VideoGame/MortalKombatMythologiesSubZero The original Midway timeline]] features one between Bi-Han (the original Sub-Zero), a mostly human [[AnIcePerson Ice Person]], and [[NobleDemon Sareena]], a demoness transformed into a beautiful girl. [[VideoGame/MortalKombatDeadlyAlliance Later]], after Bi-Han was [[spoiler:killed and [[CameBackWrong brought back as the more evil Noob Saibot]]]], she has a ShipTease with his younger brother Kuai Liang the second Sub-Zero.
** [[VideoGame/MortalKombat1 Liu Kang's New Era]] also has an example, and it involves the [[LizardFolk Zaterran]] shapeshifter Syzoth (Reptile) and Ashrah, a demon of the Netherrealm who seeks to purge herself out of all evil and achieve redemption.
* ''VideoGame/NamcoHigh'' takes this up to eleven, as ''every single romance option'' is an InterspeciesRomance. The protagonist is an alien of AmbiguousGender, a cousin of [[VideoGame/KatamariDamacy The Prince of All Cosmos]]. Dating options will include:
** [[{{Robosexual}} The ship]] from ''VideoGame/{{Galaga}}''
** [[{{Cyborg}} Anti]]-[[EvilCounterpart Bravoman]] from ''VideoGame/{{Bravoman}}''
** [[LittleBitBeastly Lolo]] from ''VideoGame/{{Klonoa}}''
** [[VideoGame/{{Mappy}} Meowkie, a cat]]
** [[{{Webcomic/Homestuck}} Terezi Pyrope]], an alien of a different species
** [[CargoShip Donko]], [[VideoGame/TaikoNoTatsujin a talking Taiko drum]]
** Several humans, such as [[{{Valkyries}} Valkyrie]]...[[ShapedLikeItself the Valkyrie]] from ''VideoGame/TheLegendOfValkyrie'', [[VideoGame/RollingThunder Albatross]], Nidia from ''Dragon Spirit'', [[VideoGame/MrDriller Mr. Driller]], Hiromi from ''Burning Force'', [[VideoGame/WonderMomo Akiho Matsuo]], [[{{Webcomic/Homestuck}} Jane Crocker]], Tomari from ''Ordyne'', and [[VideoGame/TimeCrisis Richard Miller]]
** Blue Max, a bird from ''Sky Kid''
** [[BoyMeetsGhoul Taira]] from ''VideoGame/GenpeiToumaDen'', who might also count as NinjaPirateZombieRobot, as he's an undead samurai [[{{Calvinball}} wrestleball]] player
* Creator/BioWare did it again in ''VideoGame/NeverwinterNights: Hordes of the Underdark'', where your character can romance all but one of your companions in Acts II and III (a female drow, a male tiefling, and a female elf ''ghost''), as well as an {{N|onPlayerCharacter}}PC [[OurAngelsAreDifferent trumpet archon]].
** Guaranteed for female player characters in ''VideoGame/NeverwinterNights2: Mask of the Betrayer'', where the romance option is Gann, a hagspawn. Gannayev is the product of an interspecies romance (night hag/human) as a romance option for female [=PCs=]. He has no objections based on species either. Neither does Safiya, a human, if the male character is a non-human.
* ''VideoGame/NightInTheWoods'' has, mainly, Gregg (a fox) with Angus (a bear). The player character, Mae (who is a cat), used to date a raccoon boy back when she was in junior high; and if the player decides to have Mae crash a college party, she has the option of flirting with a woman nicknamed "Bombshell" (who is a bear).
* The ''Creator/NipponIchi''-verse contains several examples:
** Laharl, a Demon, from ''Franchise/{{Disgaea}}'' is possibly paired up with Flonne, an Angel.
*** Plus, Laharl is the result of another such romance. His mother was a human.
** Salome (human, possibly) and Zetta (demon, but also in ''heavy'' denial) from ''VideoGame/MakaiKingdom'' -- though Salome probably doesn't count as human any longer, what with having become an overlord and all.
** Adell (human) and Rozalin (demon) from ''VideoGame/{{Disgaea 2|CursedMemories}}''. Both in [[SheIsNotMyGirlfriend very heavy denial]]. [[spoiler:Adell doesn't count as human either, but he doesn't know that.]]
** In ''VideoGame/Disgaea4APromiseUnforgotten'', we have Valvatorez (a vampire, which in this game is identified as a type of demon) with Artina (a human [[spoiler:who died in the backstory, but is later reintroduced as an angel.]])
** Nereids in ''VideoGame/SoulNomadAndTheWorldEaters'' mate with humans. Since they're an [[OneGenderRace all female race]] incapable of parthenogenesis, it's required for their survival.
** Also possible between humans and Sepps (see Endorph ending). Might happen between Revya and Danette in the future after the Danette (male) ending. See [[ChildhoodFriendRomance Victorious Childhood Friend]].
*** Sepp/human pairings may actually be quite common. One NPC in the game claims to be half human half sepp, Levin (sepp) has a crush on Tricia and may also hook up with Revya (if female) in the Levin-ending. Female Revya can also hook up with Gig, the [[TheGrimReaper God of Death]] in one ending.
* ''Videogame/{{Octodad}}'' has the eponymous male octopus and his human wife. Their two kids are also human. Just about no one but the EvilChef (and BigBad) is actually aware of it. [[spoiler:When his wife and son (his daughter apparently already knew) finally find out that he's an octopus, they happily accept him. Though his son does ask how he and his sister were born...]]
* ''VideoGame/OdinSphere'' has a couple of these.
** Prince Cornelius was originally a human in love with Velvet, another human, but was cursed into a rabbit-like beast called a Pooka. He initially believes that Velvet can no longer love him in that form, but fortunately it turns out not to be the case [[spoiler: and Velvet ends up also becoming a Pooka in the good ending, with them successfully reversing the curse a thousand years later.]]
** Ironically, the same can be said for Velvet's twin brother Ingway. His love interest, Mercedes, is the Fairy Queen of Ringford [[spoiler: and he spends most of his time in her company as a ''frog''.]]
* ''VideoGame/Onmyoji2016'' has the ''yōkai'' Sakura-no-sei who falls in love with a mortal man. It [[CrusadingWidow did not end well for her]].
* The first ''VideoGame/ParappaTheRapper'' game contains the heart-warming plot of an anthropomorphic dog trying to romance an anthropomorphic sunflower. (Which brings up some rather [[HotSkittyOnWailordAction interesting questions about their sex life.]])
* In the art book for ''VideoGame/PhantasyStarIV'', there's a bit of information about what happened to the heroes after the events of the game; Chaz apparently dies of illness sometime before he's thirty, leaving Rika, who has since become a guild hunter, to care for their young son, Rui, by herself.
* In the original ''VideoGame/PlantsVsZombies'', Cactus (female sentient spike-shooting cactus) is said to be dating a nice armadillo in her Almanac entry.
** Meanwhile, in [[VideoGame/PlantsVsZombies2ItsAboutTime the sequel]], Dr. Zomboss claims that [[ManEatingPlant Chomper]] has been "getting ultra cozy" with the Bikini Zombie, in a rather transparent attempt to make you distrust Chomper. The premium plant Blooming Heart is also mentioned as being distrusted by her fellow plants because she's apparently "into zombies". Another premium plant Hot Date makes zombies get attracted to him, both female [[EvenTheGuysWantHim and male]] alike.
* ''Franchise/{{Pokemon}}'':
** The series is mentioned in the anime section, but gets another mention due to the prevalence of HotSkittyOnWailordAction, which appears more readily in the games than the anime. However, it is said that all Pokemon are descended from Mew, which would make them technically all one species.
** According to Sinnoh legend in the English version of ''[[VideoGame/PokemonDiamondAndPearl Diamond/Pearl/Platinum]]'', at one point, humans and Pokémon "ate together at one table". This is a {{Bowdleri|se}}zation of the original Japanese line that explicitly states marriage occurred between the two. One of the egg groups ''is'' called "Humanshape"...
** In ''[[VideoGame/PokemonGoldAndSilver HeartGold and SoulSilver]],'' the first Pokémon in your party follows you around, and you can talk to it to check its Happiness rating. If a Pokémon's happiness is extremely high, it can exhibit signs of having a crush on its trainer. [[HoYay Yes, even if it's the same gender.]]
** There's one in the storyline of ''[[VideoGame/PokemonRubyAndSapphire Omega Ruby and Alpha Sapphire]]'' that's odd even for two Pokémon; Chaz's Machoke and Lisia's Altaria seem to be a little affectionate towards each other, despite the fact that they aren't even compatible.
* ''VideoGame/PopoloCrois'' has TheHero Pietro as the product of one, with a human father (King Paulo) and a dragon mother (Queen Sania). It's lampshaded in the opening of the anime series: a young Paulo pulls a sword out of dragon!Sania's tail, she morphs in her beautiful [[TinyGuyHugeGirl and tall]] human form, they smile at each other...
* ''VideoGame/{{Psychonauts}}'': [[spoiler:The video gotten for reaching 100% completion implies that Linda the lungfish had/has a romantic relationship with Mr. Pokeylope, a turtle.]]
* ''VideoGame/{{Pulseman}}'' tells of the titular character being the offspring of a man and an AI. Yes, man and machine had a baby. By combining his DNA and her program core, when he digitised himself inside her.
* ''VideoGame/PuyoPuyo'':
** In ''VideoGame/PuyoPuyon'', Suketoudara, a fish, is revealed to have a crush on Serilly, a mermaid. It's one-sided; Serilly refuses his offer to go out on a date, leaving him shocked.
** In ''VideoGame/PuyoPuyoFever2'', Oniko, the girlfriend of the onion pixie named... Onion Pixie, is the same species as him. She ends up falling in love with Sig, a human, which prompts one of the fights in Sig's story mode when Onion Pixie gets mad.
** Parodied in ''VideoGame/PuyoPuyo20thAnniversary'', where Maguro, a human, has a "Beauty Beam" that makes anybody who sees him fall in love with him. Piscine Suketoudara is one of the victims.
* In ''VideoGame/PuzzleQuest: Challenge of the Warlords'', Syrus Darkhunter is the product of one of these, as his mother was a human and his father was an elf. Their romance was happy, but Syrus isn't; he's not welcomed by either side of his family.
* ''VideoGame/RadiantHistoria'':
** There is a side quest called "Mankind and Beastkind" in which you show a Satyros woman named [[http://radianthistoria.wikia.com/wiki/Liese?image=Liese_8423-png Liese]] that the love she shares with a human gatekeeper shouldn't be hindered by the fact that they come from two different species.
** Your Satyros party member, Aht, has a major crush on the (human) main character, Stocke. He doesn't exactly reciprocate the same feelings, however; not because she's of a different species, but because [[PrecociousCrush she's 9]].
* ''Franchise/RatchetAndClank'':
** Most of Ratchet's [[GirlOfTheWeek Girls of the Week]] throughout the series qualify. While they're all vaguely cat-like aliens of different species, he's [[LastOfHisKind the last Lombax]].
** For a slightly more brain-damaging version, ''Up Your Arsenal'' implies an amnesiac Captain Qwark once hooked up with a ''monkey''; he's overheard apologizing to his simian sidekick Skrunch for it, saying "How could I have known she was [[MySisterIsOffLimits your sister]]?". (This revelation is, naturally, treated as TooMuchInformation).
** In ''Quest For Booty'', robot pirate Rusty Pete mentions that he once [[WhatDidIDoLastNight woke up spooning a Kerchu]] (an ill-tempered alien that [[http://images2.wikia.nocookie.net/__cb20080807085261/ratchet/images/2/27/Kerchu.png looks something like a 3-foot mutant hamster]]) after a really wild night. The rest is, [[BrainBleach unfortunately]], left to our imagination.
* ''VideoGame/RogueGalaxy'' have Deego (big bulldog person) and Angela (the not-quite-elf).
* ''VideoGame/RuneFactory'':
** ''VideoGame/RuneFactory3'', the main character's parents (although you never actually see them) were a human and a wooly (sheep-like monster). Two of your possible love interests are Kuruna (an univir, a magical horned humanoid) and Pia (a mermaid). Another girl, Raven, is half-human, half-''phoenix''. Plus there's Gaia's (who is a dwarf) crush on Evelyn (a human).
** There's also ''VideoGame/RuneFactoryFrontier'', where two of your love interests are Tabatha, an elf, and Iris, a vampire (it would seem vampires in this universe are a separate species, rather than being undead).
** The trend continues in ''VideoGame/RuneFactory4'', where depending on your character's gender you can marry an elf, a dwarf, or various [[LittleBitBeastly monsters-turned-human]]: a caterpillar girl, a horse man, a possessed marionette, and a fox [[spoiler:who were all once human themselves]].
* Hinted at in ''VideoGame/RuneScape'' between the main character and Zanik the Cave Goblin. But whether this {{shipping}} is wrong or [[ThePowerOfLove sweet]] is up in the air for debate. Confirmed by WordOfGod in [[FourthWallMailSlot Letters From The Hedge]] with a letter from Zanik saying she's not sure if her romantic interest in you (regardless of gender) is genuine chemistry or residual MindScrew from being possessed by Bandos, and she needs some time to sort out her feelings, and further supported by the devs saying her attraction to you is real but conflicted by the resurgence of the God Wars.
** The quest "Gunnar's Ground" is about helping a dwarf woo a (human) barbarian princess.
** During the Daemonheim sagas, Thok has a crush on the Gorajo Divine Skinweaver. However, the extended ending for "Thok Your Block Off" says that [[UnresolvedSexualTension she's still waiting for him to actually ask her out]].
** In the gods' storylines, Guthix (god, formerly Naragi) and Seren (goddess, formerly... [[CosmicHorrorStory it's complicated?]]) apparently had a mutual attraction, but [[UnresolvedSexualTension neither of them ever acted on it]].
** It is rumored in-universe, but never specifically confirmed or debunked, that Char (a near-human with innate fire powers) was intimate with Zaros (Seren's equally-complicated brother). You can directly ask either of them about this, and they're both vague on the subject.
** The vampyre quest series guest stars the product of a human-[[OurAngelsAreDifferent Icyene]] marriage, [[spoiler: Prince Safalaan Hallow]]. Who in turn has a very obvious attraction to [[BatOutOfHell trueborn vampyre]] Vanescula Drakan, complete with a [[DidTheyOrDidntThey private moment in her bedroom]] during "The Lord of Vampyrium" that you [[MomentKiller rudely interrupt]]. Even after "River of Blood" it's not clear whether Vanescula actually reciprocates or if she's just using him.
* In one of Telltale's [[VideoGame/SamAndMaxFreelancePolice Sam & Max games]], Momma Bosco (human) develops a serious but one-sided crush on Max (hyperkinetic rabbity thing). There's later some light ShipTease with her and Sam (anthropomorphic dog) instead.
** Not to mention Sybil marrying the giant robotic Lincoln Memorial.
** Girl Stinky and Sal. Stinky's species is a little up in the air due to {{Retcon}}s (either she's a mermaid or [[spoiler:an evil cake in human form]]), but either way, it's different from Sal, who is a giant talking cockroach.
* ''Franchise/ShinMegamiTensei'':
** ''[[VideoGame/ShinMegamiTenseiStrangeJourney Strange Journey]]'' makes fun of this: whenever Anthony falls in love with a demon, he asks you to go, find the demon and send a message of his love...and [[RunningGag every time]] he tells you he's in love with a demon, [[Funny/ShinMegamiTenseiStrangeJourney the music comes to a dead stop]]. And every single time, he's put down by the other party in the most humiliating fashion possible, though much of that is his own damn fault (spoiler warning, Anthony: if a demon looks like a little girl, it probably ''[[NoYay thinks]]'' like one, too). [[spoiler: Except for Skogsra, who's genuinely thankful she got an apology for his cowardice, and Gemori, who gives him some romantic advice per her job as a god of love.]]
** In ''VideoGame/DevilChildren'', [[spoiler: Lucifer himself]] is the parent of Setsuna Kai.
** ''VideoGame/{{Persona 1}}'': By the end of the game, it's obvious that Ideal Maki isn't human, being born of the real Maki's imagination.[[note]][[VideoGame/Persona5 In retrospect]], she's a Cognition[[/note]] Makes her crush on the protagonist go into StarCrossedLovers territory.
** In ''VideoGame/{{Persona 3}}'' and its expansion FES, there is definitely something going on between the MC and Aigis, a robot girl. In ''Persona 3 Portable'' it is possible to have a romantic relationship with [[spoiler: Ryoji]], who is a Shadow with a human mind. Similarly, the Velvet Room siblings Elizabeth and Theodore are described as "[[AmbiguouslyHuman those who rule over power]]", and can also be romanced.
** In ''VideoGame/{{Persona 4}}'', Marie and Margaret, the former of whom is [[spoiler:a Shadow similar to Ryoji above]] and the latter is another Velvet Room sibling, show romantic interest in the MC, which can be reciprocated.
*** Any romantic relationship Teddie starts would invariably be an InterspeciesRomance due to the absence of other living [[spoiler: self-aware Shadows]] in canon at this point of time. It's not limited to Teddie X Human possibilities either; he has been seen trying to start relationships with two robots (Aigis and Labrys), one goddess (Marie), and even one [[spoiler: ghost (Rei)]]. The keyword here is ''[[CasanovaWannabe trying]]''.
* At the ending of the first '' VideoGame/ShiningForce'' game, it is implied that Mae has a thing for the human player character. Mae is a centaur. It's also implied that Shell the mermaid has a crush on the main character.
* In ''VideoGame/TheSims'' you can sleep with robots, zombies, vampires, plant-creatures, aliens, werewolves, etc.
* ''VideoGame/SlyCooper'' has titular character Sly, a raccoon, and Carmelita, a fox. There's also Bentley, a turtle, and Penelope, a mouse. [[spoiler: Though with the last one, that fell through in [[VideoGame/SlyCooperThievesInTIme the fourth game]].]]
* The dog-people Caninu and cat-people Felineko of ''VideoGame/{{Solatorobo}}'' are specified in the in-game encyclopedia to be quite capable of breeding and having regular children together. Both ships that are [[ShipTease teased]] to any great length are interspecies.
* ''Franchise/SonicTheHedgehog'':
** Princess Elise, the ''human'' princess of a FantasyCounterpartCulture version of Italy, had a one-sided romance with Sonic throughout ''VideoGame/SonicTheHedgehog2006''.
** FemmeFatale Rouge (a bat) is tends to make flirtatious advances on most of the male cast, Dr. Eggman included.
** In the ''[[WesternAnimation/SonicTheHedgehogSatAM SatAM]]'' continuity, Sonic's girlfriend is half chipmunk, half squirrel. In [[ComicBook/SonicTheHedgehogArchieComics the comics]] he seems to have built an UnwantedHarem including other animal characters. In both the cartoon and the Archie Comics, he also competed with Antoine (coyote) for Sally's affections -- in the comics, this stopped after Antoine became an OfficialCouple with Bunnie Rabbot ({{Cyborg}} rabbit), who first showed a brief hint of having a thing for the [[CheeseEatingSurrenderMonkeys cowardly pseudo-French coyote]] in one episode of the cartoon. And in both canons, Bunnie's attitude towards Sonic, particularly before hooking up with Antoine, could be taken as flirtatious, what with her frequent reference to him as "sugah hog".
** Tails (fox, albeit a slightly mutated one) and Cosmo (Seedrian - a species evolved from plants) in ''Anime/SonicX''.
** During ''WesternAnimation/SonicUnderground'', Knuckles gets a new love interest in Sonic's own sister, Sonia. Sonia also had her fair share of romances with Bartley and Stripes. Also, Dingo has a VillainousCrush on her.
** In ''WesternAnimation/AdventuresOfSonicTheHedgehog'', Sonic falls head-over-heels over Breezie, a female hedgehog in a red cocktail dress who turns out to be a {{robot|Girl}}. Robotnik also builds himself a [[RoboticSpouse robot wife]] in one episode.
** WordOfGod is that in ''ComicBook/SonicTheComic'' Johnny Lightfoot (a rabbit) has feelings for Amy (a hedgehog), however the writers decided not to use the idea in any issues. There's also Tekno (a canary) and Shortfuse (a squirrel) being love interests. Apparently Amy and Tekno have also [[WordOfGay been confirmed to be less than platonic]].
** Sonic originally had a TokenHuman girlfriend named Madonna early into the development of the original game. She was ultimately dropped when they decided to make the series cuter (such as when they changed the enemies from slightly creepy monsters to the more friendly-looking Badniks).
* ''Franchise/SpyroTheDragon'':
** There's a ShipTease between Spyro and Elora (a faun) in the Original Series. In fact, it's more noticeable in the Reignited versions with Elora's more flirty animations and voice acting. Post-Insomniac prefer to pair him with dragons (such as Ember or Cynder), however that doesn't stop girls of other species from flirting with him.
** Hunter is a cheetah who ends up sparking something with the villain Bianca, a rabbit, in ''VideoGame/SpyroYearOfTheDragon''. They start dating after Bianca does a HeelFaceTurn, though Bianca [[MinionWithAnFInEvil wasn't]] a [[HiddenHeartOfGold very convincing]] antagonist in the first place.
** Sgt. Byrd is a penguin with a fairy for a girlfriend.
** Ember is a dragon who originally had feelings for Spyro, however in one handheld game she falls for an armadillo instead.
** Romeo is a slug-looking Land Blubber while his girlfriend Juliet is a bird. You have to reunite them in one level of ''VideoGame/Spyro2RiptosRage''. They're from warring species as well.
* For a more old-school reference, there is a sex scene between the Captain and [[GreenSkinnedSpaceBabe Talana]] in ''VideoGame/StarControl 2''. It is almost a ButThouMust although if you refuse enough you can skip it.
** There is also Admiral ZEX, who there is ''not'' a ([[FanPreferredCouple canon, at least]]) sex scene with, despite the fact that he has a very clear interest in the Captain. This is partly because of the fact that he's male and partly because, unlike Talana, he looks nothing like a human.
* ''VideoGame/StarFox'':
** ''VideoGame/StarFox64'' has Katt, who seems to have a thing for Falco (can you guess their race?).
** According to other ''VideoGame/StarFoxCommand'' endings, Krystal winds up with Panther, a... well, [[ADogNamedDog you figure it out.]]
* Pretty much any ''TabletopGame/DungeonsAndDragons''-based game (see below) that has any sort of romantic capability will have InterspeciesRomance. It's almost blasé in D&D, though some settings make a point of having a xenophobic nation or two - almost always evil or at least repressive to take the moral of the concept from plain obvious to {{Anvilicious}}.
* ''VideoGame/{{Startopia}}'' has the sirens (winged humanoids) providing (PG friendly) 'love' to a variety of species, from little grey aliens to giant aristocratic slugs.
* Creator/BioWare preceded this with the GayOption in ''VideoGame/KnightsOfTheOldRepublic''. Juhani is of a felinoid alien species called the Cathar. It's also heavily implied that she and a female human Padawan were a bit more than just friends.
** The Brotherhood of Shadow mod has [[spoiler:Arkanian offshoot Koybayasi and Twi'lek Channa Mae/Shadow/Sera Degana]]. It's a surprisingly sweet note in a very frightening mod.
** In ''[[VideoGame/KnightsOfTheOldRepublicIITheSithLords Knights of the Old Republic 2]]'', both romance options for a Male [[PlayerCharacter Exile]] are HumanAliens - the Handmaiden is an Echani while Visas is a Miraluka.
* In ''VideoGame/StarWarsTheOldRepublic'', some romanceable companions are of the species that are not playable (yet). The male Jedi Consular has Nadia Grell (a Sarkhai). The {{Backstory}} had [[UglyGuyHotWife Darth Malgus and his Twi'lek wife, Eleena Daru]]. Players can also invoke this trope by playing with someone from a different species than their love interests.
* ''VideoGame/{{Stellaris}}'': Empires with the Xeno-Biology Ascension perk, added in patch 2.2, are species inhabiting it are interfertile with each other. This increases your empire's immigration pull, and occasionally results in the creation of hybrid species which have traits from both of their parent species.
* Nearly every pairing in ''VideoGame/SuperLesbianAnimalRPG'' is this. To name a few, there's Melody and Allison (fox and rabbit), Jodie and Faith (tiger and unicorn), and Beth and Mary Ena (bird and hyena).
* ''Franchise/SuperMarioBros'':
** A Koopa (turtle) and a Boo (ghost) pair were two of the four heroes in the backstory of ''VideoGame/PaperMarioTheThousandYearDoor'', and another such couple can be found doting on each other in ''VideoGame/MarioAndLuigiBowsersInsideStory''.
** Pretty much all of the girls in ''VideoGame/PaperMarioTheThousandYearDoor'' seem to like Mario. All four of his female party members (a Goomba, a talking cloud, a shadow siren, and a mouse) give him a kiss on his cheek at one point. [[spoiler: Vivian even comes close to telling him her true feelings for him at the end, but then decides that he'd be much better with Peach.]]
** TEC (a computer) is crushing on Peach (human).
** Bowser, a Koopa, also has a crush on Peach. In ''VideoGame/SuperMarioSunshine'', Bowser's son Bowser Jr. [[spoiler:thinks that Peach is his mother. However, this is jossed in the ending of the game]].
** Basically the backstory in ''VideoGame/SuperPaperMario''. [[spoiler: The game's BigBad, Count Bleck (a member of the Tribe of Darkness) had fallen in love with a human women named Timpani. His father [[FantasticRacism heavily disapproved of the relationship]], and after he heard that they [[ParentalMarriageVeto got engaged]], he cursed Timpani to wander between dimensions until she (seemingly) died. Bleck then fell into a downward spiral that lead to him becoming the OmnicidalManiac seen in the events of the game.]]
* ''Super Snail'' from [=QCPlay=] Limited has a failed relationship between Li Gi-na, a spirit from Cathay that originated from a zither. While looking a like a blue legless ghost, Li Gi-na is classified as a fairy. Her ex- boyfriend is a Minotaur called the Bull Chief and their kids are known as Minorinos which look like blue ghosts with bull heads. After ditching her old boyfriend, Li Gi-na starts showing interest in Super Snail himself.
* ''VideoGame/TalesOfRebirth'' has a gajuma(beastmen) princess loves a huma(human) general seems one-sided [[spoiler: until she dies at the end and he realizes that he loves her too, giving it a BittersweetEnding.]]
* ''VideoGame/TalesOfSymphonia'' gives us several pairings between humans and elves. Pairings between angels and humans [[spoiler: do not count because angels were just humans and half-elves with their bodies modified to resemble that of what people believed angels to look like]].
** ''VideoGame/TalesOfSymphoniaDawnOfTheNewWorld'' gives us not one but two canon inter-species pairings: [[spoiler: Marta/Emil and Aqua/Richter]], though the former eventually can live out their lives as humans and the latter is one sided.
* Most ''FranchiseTouhouProject'' shipping ends up here since the majority of the characters are various types of {{youkai}}. Canonly, Rinnosuke Morichika is the result of a human/youkai pairing, and Keine is ''half hakutaku'' (a lion-dog with horns).
* ''VideoGame/{{Utawarerumono}}'' has a yamagira (human-ish creature with dog ears and tail) girl who loves a human([[spoiler:god]].)
* ''VideoGame/WarCraft'':
** The series early as Warcraft 1: Orcs and Humans there was Garona the Half-orc and [[HugeGuyTinyGirl Griselda and Turok]], a female orc and male ogre respectively; ''Warcraft 3'' reveals this coupling produced Mok'nathal (ogre-orc). Less extreme examples have been the inevitable human male/Female elf pairing as with Alleria Windrunner (elf) and Turalyon (human), Veressa Windrunner and Rhonin (same combo), ''and'' Sylvanas Windrunner and Nathanos (same combo... albeit both are undead). There's at least two orc/draenei couples, [[spoiler:and one character, Med'an, who's the child of one of those last and Medvih, thus making him 1/4orc 1/4draenei 1/2 human, though you wouldn't know it if you saw him]]. It's also hinted that Kael'Thas (yet another high elf) had a crush on Jaina Proudmoore (human), and furthermore, many people speculate that Jaina has a romantic relationship with Thrall (orc) ([[spoiler:confirmed false in Thrall: Twilight of the Aspects]].)
** Garona is an aversion of the romance aspect - she was produced via dark sorcery using a dead Draenei and Orc parent.
* ''VideoGame/WorldOfWarcraft'':
** Marvin and Tamara Wobblesprocket are a married couple. The former is a tiny gnome, and the latter is a human.
** Archaeologist Adamant Ironheart (Dwarf) and Priestess Kyleen Il'dinare (Night Elf) seem to have something going on, too. At least, she doesn't mind him calling her "darling".
** The Troll Zebu'tan is forever trying to woo the Blood Elf Alys Vol'tyr. She isn't very receptive to his advances, but her dialogue makes it pretty clear that it has little to do with his species; she doesn't want him because she's spoken for and he's a creep.
** ''VideoGame/WorldOfWarcraft'' has several "Steamy Romance Novels" that can be pickpocketed or looted from NPC humanoids. Most of them involve "Marcus", a male human paladin who has either slept with or dated members of nearly every playable race in the game, from the feasible (night elf and blood elf), odd (a female gnome warlock) to the disturbing (tauren and undead). There's also Anveena ([[spoiler:human embodiment of the Sunwell]]) and Kalecgos (a blue dragon). Possibly also Tyrygosa and Jorad Mace. And now, Jaina and Kalecgos; helps that he has a humanoid form...
** ''Warlords of Draenor'' has a mutual attraction between Baros Alexston, the (human) city architect of Stormwind, and Lieutenant Thorn, the ([[OurWerewolvesAreDifferent worgen]]) Alliance garrison's mission specialist; though she spends most of her time in human form in the garrison, he apparently likes her [[UsefulNotes/FurryFandom "long, silky fur"]]. [[spoiler:Unfortunately, he is killed in an attack by the Iron Horde late in the campaign. Afterwards, Thorn remains in worgen form, and [[TragicKeepsake keeps the]] [[TheTragicRose rose he wanted to give to her]] [[TragicKeepsake on her desk.]]]]
* ''VideoGame/XenobladeChronicles1'':
** There are plenty of {{Mayfly December Romance}}s between [[HumanAliens Homs]] and [[OurElvesAreDifferent High Entia]], who besides the MercurysWings and PointyEars are fairly similar. One sidequest focuses on helping such a pairing out, and one of these manages to sneak its way into the main story too.
** Relationships between other species are implied, but rarely explored. In one particular sidequest, a female Homs shows interest in several men, one of them [[RidiculouslyCuteCritter a Nopon]], but her interest in him quickly goes away once she realizes just what she's doing.
* ''VideoGame/XenobladeChroniclesX'': Most of the romance in this game is implied rather than explicit, and while there are plenty of interspecies friendships happening, romances seem very rare. The one that we do see involves a human and a ''[[PredatorPastiche Prone]]'', of all things.

----