The following games have their own pages:
* InterspeciesRomance/DungeonsAndDragons

* ''TabletopGame/TheWorldOfDarkness'': There are all sorts of of human/non-human goings-on in both settings, including vampires and werewolves. Most splats are non-human in some way, except Hunters and Mages, and most of them can mate and even reproduce with humans under at least some circumstances. The only ones truly unable to do so are Wraiths, being wholly immaterial. Indeed just about every supernatural engaged in romance with humans, even the vampires (though less so due to their deadness). Generally the likelihood of said romances are similar between the two versions of a given splat:
** Vampires are living corpses -- although they can have sex if they choose, their sex drive is mostly so dead they're hardly ever in the mood -- as are [[TabletopGame/PrometheanTheCreated Prometheans]], so they're sterile to begin with. Bizarrely, in the ''TabletopGame/OldWorldOfDarkness'' there were very unusual circumstances in which [[TabletopGame/VampireTheMasquerade vampires]] and [[TabletopGame/KindredOfTheEast kuei-jin]] could actually have half-human offspring, but this was far from the norm.\\
''[[TabletopGame/VampireTheRequiem Night Horrors: The Wicked Dead]]'' introduces the [[TabletopGame/NewWorldOfDarkness nWoD]] take on the {{Dhampyr}}, which is born when a human and a vampire engage in carnal relationships backed by magic or a massive amount of emotional focus -- [[ThePowerOfLove a deep sincere love]] is mentioned as the most common, and most tragic, cause of their creation. And because the laws of nature are already being broken by their creation, ''any'' combination of a vampire/human pairing can produce them. [[HomosexualReproduction Even two men or two women]]. And when a heterosexual couple are the parents, [[MisterSeahorse the male can end up carrying the baby instead of the female]] -- this is (fortunately) usually only caused by magic and tends to occur when it's a male vampire/female human couple. Male humans can carry the dhampyr safely... but [[DeathByChildbirth delivery is another matter]].\\
Even though Prometheans are sterile, it may happen occasionally that one finds themselves a parent. These children are known as Scions, and they're both able to sense when a Promethean draws near and unaffected by Disquiet.
** Werewolves only hit lycanthrope status at puberty (though no one would ever consider trying to have sex with a werewolf in its [[UnstoppableRage War-Form]]...unless they were pretty much invincible or into self-snuff and that got creepy really fast). In ''TabletopGame/WerewolfTheApocalypse'' all the shapeshifters have families, including animal and in most cases also human Kinfolk who are, in almost all ways, entirely normal. Most same-shapeshifter pairings inevitably produce either a sterile and deformed Metis or no child at all, and even the Changing Breeds with fertile "Metis" can never produce enough to maintain their population without breeding with humans and their animal species. (Some Garou have speculated that Gaia designed them that way deliberately, to prevent them from ignoring the people they should be protecting.)\\
In ''TabletopGame/WerewolfTheForsaken'', this changed for werewolves. Because of the {{Squick}} implications, werewolves no longer have sex with actual wolves, and view the idea the exact same way that humans do (although this hasn't stopped certain perverts). Werewolves cannot reproduce with other werewolves, as the result is a [[FetusTerrible spiritual abomination]] that grows up to hunt werewolves. Humans with werewolf blood are known as "wolf-blooded" and are always marked by this blood. The ''Blood of the Wolf'' sourcebook states that werewolves are sterile in their wolf-shape, but ''also'' states that men can fraternize with wolves and sire normal wolf offspring ([[MuggleBornOfMages that are not and never will be werewolves]]). Now think about [[FridgeHorror how those two statements are reconciled]], [[BrainBleach or do not think about it]]. ''Night Horrors: Wolfsbane'' has a Werewolf AntiChrist DarkMessiah who is the child of a werewolf and a wolf. [[DeathByChildbirth He was born 100% human.]]
** In ''TabletopGame/ChangelingTheDreaming'' changelings are perfectly capable of having children; some are changelings themselves, some are ordinary humans, and some, the Kinain, inherit a touch of fae magic. In ''TabletopGame/ChangelingTheLost'', however, changelings are usually sterile, thanks to their transformation, but the occasional child has been known.
** [[TabletopGame/DemonTheFallen The Fallen]] [[DemonicPossession possess]] humans, and thus can mate and procreate as normal for a human. [[TabletopGame/DemonTheDescent The Unchained]], meanwhile, have human disguises so comprehensive they're able to reproduce in the same way, with the child inheriting their parent's connection to the workings of the universe.
** There was a flaw in the original Spell of Life which meant that the mummies it created were sterile. The [[TabletopGame/MummyTheResurrection improved version]] allows mummies to have human children.
* Almost completely absent in ''TabletopGame/{{Warhammer 40000}}'' (everyone is either an AbsoluteXenophobe, asexual, or rigidly enforces breeding), but it pops up from time to time:
** Both the Dark Eldar and [[ReligionOfEvil the followers]] of the [[MadGod Chaos God]] [[SenseFreak Slaanesh]] indulge in gratuitous interspecies rape on occasion, but that's primarily because their MO runs on {{Squick}}.
** Very early fluff hinted the [[CanonSue Ultramarines]] have an human/Eldar hybrid among their number ([[MarySue and was both their Chief Librarian and an Astropath]]), though this is somewhat undermined by that same fluff also stating that Eldar have, [[YouFailBiologyForever among other horrendous biological impossibilities]], zero body fat (but for some reason the females still have rather prominent breasts) and [[BizarreAlienBiology TRIPLE HELIX DNA]]. Like most things from the early fluff, this has been stricken from the collective fandom consciousness.
** Genestealers combine this trope with FaceFullOfAlienWingWong, a sub-species of [[HordeOfAlienLocusts Tyranid]] that focus on infiltrating target populations. They do this by changing a target's DNA slightly, making the target absolutely devoted to the Genestealer and Tyranids in general, and horny. Any child of the targeted creature (known as a Brood Brother) is less of the parent race and more Tyranid, until by the fourth generation Brood Brothers (well, Sisters) give birth to purestrain Genestealers.
* Although "romance" wasn't involved, the earliest edition of ''TabletopGame/WarhammerFantasyRoleplay'' had half-orcs in it, as well as a race called the fimir, who consisted of sterile spellcasting females and fertile males, and thusly kidnapped human women to propagate themselves. Strangely, though most elements of that time (like half-orcs and gnomes) have been consigned to the dustbin of RetCon, fimir get an oblique mention in the Sigmar trilogy from Black Library.
* ''TabletopGame/{{Exalted}}'':
** If it exists and can have sex, then some Exalted has had sex with it. The Lunars above all, that's how Beastmen came to be. If it makes a difference, the Lunars have the ability and usually the inclination to ask animals first, and shapeshift into the same species. Beastmen, for the record, are usually conceived when a Lunar and a human ''or'' a Lunar and an animal mate in a [[RealityIsOutToLunch Wyld bordermarch]]... with [[{{Squick}} the Lunar in a form different from their mate]]. (Geoff C. Grabowski once defended the Lunars' predilections by pointing them to ''TabletopGame/WerewolfTheApocalypse'' with the words "[=---=] This Wolf Or The Earth Will Die". (Direct quote.))
** The game has rules for various types of "God-Blooded," beings with one normal mortal parent and one Exalted or non-human parent. That parent may be an Exalt, a faerie, demon, a god, an elemental, or even a ghost. Sex, let alone breeding with, anything besides a Dragon-Blood is taboo in Realm culture, and interspecies pairings are frowned upon by the Celestial Bureaucracy and many other cultures. But plenty of gods give the finger to their superiors and plenty of cultists like to summon demons for disturbing uses. For ghosts, reproduction requires an obscure and hard-to-learn power. Gods, Lunars, faeries, demon-worshippers, and Deathlords all value God-Blooded as useful minions (or slaves) with a measure of their parents' abilities but not nearly enough power to pose any threat to their creator or owner. They may also lack their non-human parents' frailties, such as Fae-blooded and Half-demons who can live in Creation indefinitely without problems. Lunars also like to spawn whole armies of Beastmen, since their own numbers are so limited.
** Interestingly, some God-Blooded are born to parents who subvert this trope; some gods have ways of reproducing that don't involve anything remotely resembling sex, especially those with totally non-human anatomy. If you get pregnant from inhaling magic pollen, does it really count as romance?
* In one of the story arcs of ''MagicTheGathering'' [[ Mirri]] (a [[CatGirl cat warrior]]) had an unrequited crush on her (human) childhood friend [[!Gerrard%20Capashen Gerrard]].
** Currently, there seems to be a [[ShipTease ship tease]] going on between the human Planeswalker Jace and the Gorgon Planeswalker Vraska. Jace’s previous romance involved the immortal necromancer [[TheNecromancer Liliana Vess]].
* ''TabletopGame/{{Ironclaw}}'' only hints at the possibility of interspecies romances in the main book. However the main character of the novel ''Scars'' is the daughter of a grey fox noble and a red fox servant, and a raccoon has an unrequited crush on her. And the Book of Jade supplement has a legend of an ill-fated romance between a dragon prince and a peasant vixen; the dragon was killed by his jealous brother and the vixen turned herself into a dragon through force of will to avenge him, then she laid nine eggs and her sons developed dragon magic that gradually makes the user more draconic.
* ''TabletopGame/RocketAge'' has the human Thomas Moore and Martian Princess Fayiltha of Polintal. Since Moore was such a hero to Polintal the city's Kastari declared him a Silthuri soul in a human body and allowed them to marry.