* All over the freaking place in ''ComicBook/ArchieComicsSonicTheHedgehog''. And a future arc, "Mobius: 25 Years Later", suggests [[NoBiochemicalBarriers they'll have children]].
** It expands to "No Bio''mechanical'' Barriers". The same arc suggests Bunnie, who is ''robotic from the waist down'', will have children, too!
*** Actually in certain continuities, Belle and Jacques (Bunnie's kids) could actually be born normally (so to speak) as Bunnie is cured of her robotization...though given that plotline, some fans [[FanonDiscontinuity will likely ignore it]].
* The entire point of Creator/PhilFoglio's adult comic ''{{xXxenophile}}''.
* ''{{Comicbook/Bone}}'' has Fone Bone and Thorn; while it's more played as Fone Bone being in love with Thorn, [[WillTheyOrWontThey Thorn never says anything about not being in love with him back]], and [[spoiler: had Fone Bone not decided to go back to Boneville at the end, it is stated that he and Thorn would have ruled the valley as king and queen.]]
* ComicBook/{{Nightwing}} [[Comicbook/TeenTitans and Starfire]] (human/alien) in at least one continuity of Franchise/TheDCU.
** Same goes for their fellow Titans, Beast Boy/Changeling ([[VoluntaryShapeshifting whatever he wants to be]]) and Comicbook/{{Raven}} (half demon.)
** There are other Titan couples as well, such as ComicBook/{{Superboy}} (human/alien hybrid) and WonderGirl (demigod).
* Professor Charles Xavier and the Shi'ar Empress Lilandra in ''Comicbook/{{X-Men}}''.
** Made worse by the fact that Lilandra is descended from ''avian'' stock, Charles from primate stock. OTOH, the Celestials might have reengineered both breeds to make them compatible. The Shi'ar seem more primate-like than evolution would plausibly manage...
* Creator/MarvelComics ''Comicbook/HowardTheDuck'' had Howard (intelligent talking duck from an alternate reality) and Beverly (human). This was played ''way'' too straight in [[Film/HowardTheDuck the movie]].
* The Kree superhero {{Captain Mar-Vell}} loved many a GreenSkinnedSpaceBabe, which is why all three of his children were hybrids - Genis and Phyla (Kree/Eternal) and [[Comicbook/YoungAvengers Hulkling]] (Kree/Skrull). Hulkling is in a relationship with fellow superhero Wiccan, which is not only interspecies but also homosexual. Of course, his half-sister Phyla and her human girlfriend Moondragon have [[HoYay Les Yay]]. [[BuryYourGays Or rather had.]]
* Karolina (Majesdanian) and Xavin (Skrull) in ''{{Comicbook/Runaways}}''.
* Comicbook/{{Nova}} (human) and GreenSkinnedSpaceBabe (literally) Gamora, in ''ComicBook/{{Annihilation}}''. Before (and after) Gamora, Rider was with Namorita (Atlantian Mutant/Clone). Namorita's metamorphosis into Kymera (much less human looking form, resulting from her ancient Atlantean DNA) didn't ruin this relationship.
* For a long time, the {{Comicbook/X-Men}} had ComicBook/{{Dazzler}} (human mutant) and her husband, Longshot (interdimensional alien). Since their divorce, Longshot seems to have jumped on the BoldlyComing bandwagon of interdimensional relations.
* Depending on which origin story you actually believe, Rictor (human) and Shatterstar (alien-ish.) are this.
* ScarletWitch (mutant) was married to the android TheVision for many years. Her brother {{Quicksilver}} married {{the Inhuman|s}} princess Crystal.
** The former might not be an example, since the Vision ''might'' have been designed to be compatible. Is an artificial person of human design a different species? As for Crystal and Pietro, the Inhumans and mutants are two branches of one breed anyway, so that doesn't really fit the trope.
** Later, Crystal was remarried to Ronan the Accuser (Kree).
* Nightcrawler (mutant) and Cerise (Shi'ar).
** ''[[WesternAnimation/{{X-Men Evolution}} Evolution]]'' also has Nightcrawler/Amanda (a human).
* [[Comicbook/SubMariner Namor]] (human/Atlantean hybrid) married GreenSkinnedSpaceBabe Marrina, but also found time to pursue the human (and all-too-married) Invisible Woman.
** Namor and that lake-monster queen from Tabula Rasa
--->'''Hope''': Ick! Ick! Ick!
--->'''Namor''': You are only showing your parochialism and prejudice. She is a dignified queen of a noble people. [[ThirdPersonPerson Namor]] is nothing if not cosmopolitan in his tastes.
** Also, there's been flirting and suggestions of future hookups between Namor and Hepzibah (an alien skunk woman. Well originally a skunk woman, a lot of artists these days tend to draw her as a CatGirl or even just a [[HumanAliens palette-swapped human]], but whatever).
** Atlanteans in the MU are a branch of the human race, so this would me more like interSUBspecies romance.
** Namor, as implied above, is the result of one of these pairings: human father and Atlantean mother. His cousin Namora has a human mother and Atlantean father. As they're effectively the only members of their kind, most any romance they pursue (aside from [[KissingCousins each other]]) is one of these.
* One of the most exteme cases in the Marvel Universe was Thena (one of the Eternals) and Kro (one of the Deviants), a true [[StarCrossedLovers Monatgue and Capulet romance]], seeing as their two races were sworn enemies.
* [[Franchise/{{Superman}} Lois and Clark]] are probably the most famous example of interpecies romance (even though he's a {{Human Alien|s}}).
** The Creator/LarryNiven essay ''[[http://www.rawbw.com/~svw/superman.html Man of Steel, Woman of Kleenex]]'' goes into quite a bit of detail on the various issues regarding Kal-El's sex life, possibly farther than some would prefer.
*** ''{{Series/Smallville}}'' addressed the essence of Niven's concerns by noting that the "training" that Jor-El had arranged for his son included "control" in that specific aspect. Apparently Clark's parents were ''expecting'' him to get involved in an InterspeciesRomance and prepared him for handling the tricky aspect of intimacy.
** Superman also had a relationship with Franchise/WonderWoman in the ''ComicBook/KingdomCome'' mini-series.
* Also from DC, [[Franchise/GreenLantern John Stewart]] married Katma Tui (alien) and had a long-standing relationship with Merayn Dethalis (also alien). ''WesternAnimation/JusticeLeague'' paired him up with Hawkgirl and featured Katma as an old flame who he was still on good terms with.
* The [[Characters/GLGreenLanternCorps Green Lantern Corps]] seems rife with this. Hal Jordan and Arisia, Kyle Rayner and Soranik Natu, and when you bear in mind that nearly every member of the Corps is a different species, when relationships between members of the Corps were banned over 200 resigned in protest.
* Mossy earth elemental Comicbook/SwampThing and his human wife Abigail Arcane. Played with considering the nearby town finds out and convicts her of {{bestiality|IsDepraved}}. Abby flees to Gotham City where the police hold her, causing Swamp Thing to go ballistic to free her. Franchise/{{Batman}} finally talks the Mayor into giving in considering that if he wants to hold Abby for having a relationship with a non-human sapient being, then he'd better arrest Lois Lane, among others, for her relationship with an admitted extraterrestrial, Superman. Since busting the world's greatest superhero's girlfriend for bestiality would look very, very bad and ridiculous in the media, the Mayor instantly gives in.
* Among the first ComicBook/{{Supergirl}}'s boyfriends were a human, a green-skinned Coluan, an Atlantean merboy, and, er, her horse. (He was in human form at the time, admittedly, but there was still a kind-of relationship between them after he was turned back; it probably helped that he retained most of his intelligence.)
* Pretty much the point of the ''{{Barbarella}}'' comic strip and carried over, to a lesser extent, in TheMovie.
* ''Comicbook/ElfQuest'': I'm gonna have to spoiler this whole thing because it involves a major plot revelation. [[spoiler:In ancient times Timmain (super-advanced humanoid alien in elf form) shapeshifts into a wolf and mates with the alpha male of a wild pack. result: Timmorn Yellow-Eyes, half-elf, half-wolf and father of the Wolfrider tribe. Many generations later the pure-blooded elf Winnowill views the Wolfriders' origins with disdain, asking the pertinent question: "Do they renew their kinship even now?"]]
** This disdain is hypocritical since [[spoiler:Winnowill is soon revealed to be the mother of Two-Edge, who is half elf/half troll.]]
** There are also some attempted human/elf pairings, which generally go badly because the elves' "bloodfire" is too intense for humans, although centuries after the main storyline the shapeshifting elf Jink enjoys a number of successful partnerships with humans of both sexes. Since she does seem to have a weakness primarily for telepaths, it may be that the elf/human compatibility issue involves a psychic element...that, or she just has [[{{Pun}} worked out the kinks]] through experience.
* ''ComicBook/{{Legion of Super-Heroes}}'': there are a lot of interspecies romances in the Legion; some of the more notable are Brainiac 5(Coluan)/Supergirl (Kryptonian), Colossal Boy (Human)/Yera (Durlan).
** Just about all major cast relationships are Cross-species; the Legion is compromised of tons of different species hanging out together 24/7, almost all raised with no species boundaries whatsoever.

* The Archie-published ''ComicBook/TeenageMutantNinjaTurtlesAdventures'' featured three such relationships. The first two involved mutant turtle Raphael, who became involved with two mutant fox women at different points of his life, and even ended up marrying one of them. On the other hand, there was the relationship between musician Mondo and his girlfriend Candy Fine, which persisted even after Mondo was turned into a mutant gecko.
** Not to be left behind, the [[ComicBook/TeenageMutantNinjaTurtlesMirage original incarnation of the TMNT]] has featured two different interspecies romances. The first occurred between Michelangelo and "Seri" (reptilian alien), while the second will occur between Leonardo and human superheroine Radical several years into the series' future.
However in "Nickelodeon's/TeenageMutantNinjaTurtles Animated Adventures" Donatello (Donnie) is in love with April O'Neil [[spoiler:April O'Neil is soon revealed to be actually a MUTANT of half Kraang Alien/half human.]] Also there is Leonardo(Mutant Ninja Turtle)& Karai (full human) However since Karai is part of the Foot clan, they had become rivals especially since [[spoiler: Karai is actually Miwa & the daughter of Master Splinter & it is soon revealed to be the daughter of Master Splinter & his wife Teng Shen. Though she does not know it herself, though Leonardo was clearly very attracted to her]].

* ''Comicbook/{{Firebreather}}'' stars the son of a human woman and a CaptainErsatz version of Godzilla who fell in love during one of his rampages.
** Wrong Ersatz. The original concept of Firebreather was for ''Comicbook/YoungAvengers'', and he was to be the son of Fin Fang Foom.
** [[{{Comicbook/Nextwave}} FIN FANG FOOM! Has been burning with the desire to mate since 1956!\\
FIN FANG FOOM! Has absolutely no genitalia whatsoever!\\
FIN FANG FOOM! Oh, you cannot]] ''[[Comicbook/{{Nextwave}} imagine]]'' [[{{Comicbook/Nextwave}} how pissed off he is.]]
* The ''Franchise/StarWars'' EU comics have their fair share of InterspeciesRomance.
** The downsides to be explored a bit more in others. For instance, one story features a Gotal who enjoys sleeping with members of other species. Or he did, until he slept with a female from a species that eats the male alive after sex.
** The ''Rogue Squadron'' series had a romance between a Calamari and a Quarren: [[DefectingForLove Romeo & Juliet]] [-[[RecycledINSPACE IN SPACE!]]-], in short. And in one arc it was implied that Janson and Hobbie slept with a pair of Bothans.
** One of the most prominent romances of the ''Clone Wars'' comics was between Jedi Masters Tholme (human) and T'ra Saa (Neti). Neti are extremely long lived, [[VoluntaryShapeshifting shapeshifting]] ''{{plant|Aliens}}s''.
** At least one of the comics set during the prequels had a fair bit of ShipTease between the aquatic Kit Fisto and Twi'Lek hottie Ayla Secura. Talk about Naughty Tentacles...
*** It's pretty much taken for granted in the Franchise/StarWars universe that Twi'lek women are desired by males of all species - and yes, it often really ''is'' due to their "naughty" ''lekku'', which can be trained to perform sensual functions. It was used rather disturbingly in A. C. Crispin's novel ''The Hutt Gambit'', where a young Han Solo is [[AbhorrentAdmirer (to his chagrin)]] leered at by an ''elderly'' female Twi'lek.
** Cade Skywalker (Human) and Deliah Blue (Zeltron) from ''Comicbook/{{Legacy}}''.
** Zayne Carrick (Human) and Zareal (Arkanian off-shoot) from ''Comicbook/KnightsOfTheOldRepublic''.
** Lucien Dray (Human) and Q'Anila (Miraluka) from the same series.
* A notable storyline in Comicbook/TheAvengers had Mantis (human) married to a telepathic alien ''tree''.
* ''Comicbook/DoomPatrol'' villains the Brain ([[BrainInAJar a disembodied human brain]]) and Monsieur Mallah ([[EverythingsBetterWithMonkeys a genetically altered super intelligent gorilla]]). For some reason, when comics fans discuss this, they only focus on the fact that they're gay.
** Considering they're a crack pairing from the start, there's really not much else to discuss. Except maybe what poking a brain with THAT feels like.
*** Interestingly, there are no nerve endings in the brain for registering pain. That means Mallah could do anything he wanted to with the Brain, and he would never feel it.
* Echiboo (hamster) and Luna-P (pig) in ''Manga/AoiHouse''. Pretty much [[GagSeries par for the course,]] actually.
* ''[[ComicBook/TwoThousandAD 2000 AD's]]'' ''Lobster Random'' ... a mechanophile. That is a (modified) human who is sexually attracted to robots. And not human looking robots either...
* ''Astonishing {{Comicbook/X-Men}}'': Beast/Brand. Complicated, since he's a human mutant who became more animalistic as he got older and now looks like a giant blue cat, and she looks mostly human and is actually half-alien. Apparently her dad was a huge blue furry thing, which [[DaddysGirl takes it into even more perverted territory]].
* In the WesternAnimation/DonaldDuck comic "The Old Castle's Secret," the jewel thief Diamond Dick claims that he knew about the hidden [=McDuck=] treasure because his "third wife was a [=McDuck=] on her great grandfather's side." Diamond Dick is a dog. Apparently something... interesting... has been going on in the [=McDuck=] family tree.
** ComicBook/DisneyMouseAndDuckComics in general occasionally have mixed-species pairs showing up as background characters in a panel or two.
* The eventual romance and implied sexual relationship between JimmyOlsen (human, with some plot-related variations) and the Forager ([[GreenSkinnedSpaceBabe really hot female purple-skinned alien bounty hunter humanoid INSECT]]) in ''Comicbook/CountdownToFinalCrisis''.
* Toyed with in FrankMiller's ''TheDarkKnightStrikesAgain'', where Hal Jordan [[spoiler: whose control over his powers now renders him virtually omnipotent]], has left Earth and is now living [[spoiler: on Mars]], where he lives a happy, wholesome family life with his wife and son. Unlike most examples of this trope, the [[spoiler: Martians]] are not rendered physically attractive or appealing in any way; Hal Jordan instead uses his power [[spoiler: to make himself a Martian, completely capable of maintaining the form indefinitely, as well as capable of breeding with other Martians]], and is extremely reluctant to return to Earth [[spoiler: after receiving Batman's transmission]], until his wife urges him to help his own people. He only reverts back to his human form after he has already left [[spoiler: Mars]], and is quick to return as soon as his business on Earth has been finished [[spoiler: which involved him multiplying his size to that of many times the Earth, able to grasp the entire planet in his fist, crushing Lex Luthor's planet wide multi-trillion dollar WMD satellite network while leaving the planet itself unharmed.]]
* In addition to Brainiac 5 (mentioned above), ComicBook/{{Supergirl}} (Kryptonian) had a quasi-romantic friendship with [[Franchise/TheFlash Captain Boomerang]] (human) and an actual romance with Apokolips native Power Boy. And had a crush on [[ComicBook/{{Nightwing}} Dick Grayson]], but that [[MrFanservice hardly counts]].
* Oh, ComicBook/TankGirl, as if your {{sociopathic hero}}ics weren't enough, you also have to get involved with Booga. The mutant kangaroo. And then cheat on him with your ''tank''... Yeah, it's that sort of comic.
* RomSpaceKnight was in love with the Terran Brandy. On the plus side, Rom is a Galadorian, basically a branch of the human race. On the minus side, he'd been cyborged into an all-covering suit of plandanium armor. On the plus side, it was theoretically possible for him to become a normal man again. Still, whether Rom and Brandy count as an interspecies liaison is a judgement call.
* DC once printed an {{Elseworld}} story (back when they're still called "Imaginary Stories") where Lois Lane had been killed after {{Franchise/Superman}} settled down and had a daughter with her. At one point, he created a robot duplicate of her, which [[http://www.supermanfan.net/main/wp-content/uploads/2010/05/loisdead-robot.jpg proved to be all too lifelike]]. Apparently, UncannyValley doesn't faze some people.
* [[Comicbook/FantasticFour Johnny Storm]] and his former wife [[GreenSkinnedSpaceBabe Lyja]]. (Johnny had thought that she was human when he married her - she's a [[{{Shapeshifting}} Skrull.)]] In the [[MarvelComics2 MC-2]] Universe they are still married and have a son, Torus.
* There's a children's comic called ''Mr. Badger and Mrs. Fox'', it's meant as AnAesop about blended families.
* The Comicbook/IncredibleHulk (gamma-irradiated human) with Jarella (from K'ai) and Caiera (Shadow Person). He had two sons from his relationship with Caiera.
* In the Howard Chaykin comic ''Comicbook/AmericanFlagg!'', one of Raul the (talking) Cat's favorite TV programs was titled "Interspecies Romances."
* Crusader Adam of Destine (later simply Adam Destine) and the djinn Elalyth, parents of the Destines in ''Comicbook/ClanDestine''.
* The North Wind and [[spoiler: Bigby's mother Winter]] from ''ComicBook/{{Fables}}''. [[TheBigBadWolf Bigby]] and Literature/{{Snow White|AndTheSevenDwarfs}}.
* ComicBook/LesLegendaires has [[TheLancer Gryf]], a [[BeastMan Jaguarian]], being part of a LoveTriangle with [[ActionGirl Shimy]], an [[OurElvesAreBetter Elf]] with ElementalPowers, and [[SixthRanger Shun-Day]], an [[OurDemonsAreDifferent artificially magically engeneered being created from the arm of a demonical]] EvilSorcerer. It also has [[EvilTwin Dark Jadina]], an evil clone of one of the protagonist, being the DarkMistress of [[BiggerBad Anathos]], a GodOfEvil;
** The concept is actually lampshaded in-universe when Shimy asks her mother, Captain Shamira, how she'd react if she was gonna marry a human. Shamira expresses discomfort with the idea, merely answering her daughter to shut up. [[spoiler:Ironically, [[HypocriticalHumor Shamira later has herself a relationship with human king Halan]].]]
* ''ComicBook/WerewolfByNight'''s Jack Russell (a werewolf) has had several long term relationships with human women.
* ''ComicStrip/{{BC}}'' has John the tortoise and Dookie Bird, who also had a fling with a pelican at one point.