* ''Webcomic/SluggyFreelance''. Ten years on, and we ''still'' haven't found out what the title actually means, we just know it's not the name of any of the characters.
* Subverted in ''Webcomic/NintendoSuperSquad'', which attempts to read like a comic drawn by an idiotic thirteen-year-old boy. The comic is about to introduce "Metroid", who the characters all mention is a strong woman who looks great in a bikini, so we naturally assume that Metroid is Samus Aran, the hero of the ''{{Metroid}}'' games -- but when Metroid arrives, she actually ''is'' a Metroid, the eponymous monster of the series.
** ...but played straight in ''Webcomic/SkinHorse'', when WholesomeCrossdresser Tip is [[http://www.webcomicsnation.com/shaenongarrity/skinhorse/series.php?view=archive&chapter=34849 challenged to name one (other) trustworthy crossdresser]].
* ''Webcomic/ElGoonishShive'' is apparently its creator's old nickname and has no other connection to the story. They lampshade this in one strip, bringing in a hired goon for one panel to "put the goonish in El Goonish Shive".
* Parodied in one issue of ''[[Website/PlatypusComix Mulberry]]'', as the titular heiress watched a show on TheCW about her hometown. The nerdy gamer exclaimed at one point, "I've almost rescued Princess Franchise/BioShock!"
* In ''Webcomic/Girly'', the lead character [[spoiler: Otra]] constantly attempts to correct people at first to what her real name is after being called "Girly". making her accidentally a [[MetaGuy Meta Chick]]
* [[http://shinka.smackjeeves.com/comics/683092/0-0-0/ Shinka: The Last Eevee]]. The Eevee's name is Nick. [[WordSaladTitle What "Shinka" means hasn't been explained yet.]]
** Although now that [[spoiler: Nick has evolved into a Leafeon]] the [[WordOfGod author has stated]] that the title doesn't refer to him at all, and is not even the name of a character. It's used in the title because it's the Japanese word for evolution and this is a webcomic that heavily features Eeveelutions. Apparently "shinka" can also mean "one's true worth", so that will probably come into play at a later point [[spoiler: if it hasn't already with Nick's evolution]].
* Zig-zagged by ''Webcomic/SchlockMercenary''. The title means "cruddy mercenary," but "Schlock" is also the name of the amorphous pile-of-poo character, [[CaptainObvious a mercenary]] whose parents [[UnfortunateNames must have hated him]]. Except [[SpotlightStealingSquad he isn't really the main character anymore, having been largely displaced by the captain]], whose name is Tagon. So it's somewhat of an ArtifactTitle, and can be sort of confusing.
* The chess-player in ClockworkGame is ''The Automaton'', not ''The Turk''.