* ''WesternAnimation/TeenTitans'': Beast Boy and Cyborg. Or, alternatively, Cyborg and Robin. Also, Starfire and Raven.
* ''WesternAnimation/WildKratts'': The Kratt brothers. Also for all four of their shows as well.
* All of Homer's drinking buddies from ''WesternAnimation/TheSimpsons'' qualify, but especially [[ThoseTwoGuys Lenny and Carl]].
* Mr. Nosey and Mr. Small in the 2008 ''WesternAnimation/TheMrMenShow''.
* Korra and Asami in seasons 3 and 4 of ''WesternAnimation/TheLegendOfKorra'' - although season 4 stretches the "heterosexual" part to the absolute breaking point. [[spoiler: The series ends with them going on a Spirit Wold vacation, holding hands and gazing at each other, all directed in a way that evokes Aang and Katara's kiss at the end of Avatar. Ultimately subverted as WordOfGod [[http://bryankonietzko.tumblr.com/post/105916338157/korrasami-is-canon-you-can-celebrate-it-embrace confirmed]] that they laid subtext for a possible future romance through the seasons- before going for broke at the last minute.]]
** It's also hinted that Aang and Zuko's relationship may have eventually developed into this.
* ''WesternAnimation/PinkyAndTheBrain'', though in all fairness, they're forced to live in a cage. They break out a lot, though.
* [[WesternAnimation/ChipNDaleRescueRangers Chip and Dale]]
** Arguably Monty and Zipper as well.
* ''Franchise/{{Transformers}}'' has a fair number of these thanks to its LoadsAndLoadsOfCharacters, spread across the various continuities.
** ''WesternAnimation/TheTransformers'' (cartoon):
*** Optimus Prime and Bumblebee. Particularly when Bumblebee [[FreudWasRight drives into Optimus's trailer when in vehicle mode]].
*** Red Alert and Inferno
*** Hoist and Grapple
*** Thundercracker and Skywarp
** ''ComicBook/TheTransformers'' (comic):
*** Needlenose and Spinister
*** Runabout and Runamuck
*** Dreadwind and Darkwing
*** Nightbeat, Siren, and Hosehead
** ''WesternAnimation/TransformersAnimated'':
*** Bumblebee and Bulkhead
** ''WesternAnimation/TransformersPrime'':
*** Wheeljack and Bulkhead
** ''TransformersTransTech'':
*** Jackpot and Hubcap
* ''WesternAnimation/DarkwingDuck'' and Launchpad [=McQuack=]. Darkwing called Launchpad his "{{sidekick}}", but the dynamic was different. There's even less explanation for his living in DW's civilian house, plus Launchpad didn't even bother with a SecretIdentity.
* [=SpongeBob=] and Patrick from ''WesternAnimation/SpongebobSquarepants''.
* Following the series' return, Stewie in ''WesternAnimation/FamilyGuy'' seems to have abandoned his plans for world domination just to have more time to hang out with Brian, formerly his arch rival. "Brian & Stewie" even has them admit that they love each other as friends..
* Mac and Bloo from ''WesternAnimation/FostersHomeForImaginaryFriends''. Never mind the fact that Bloo is a figment of Mac's imagination... Although, to be fair, most of the supporting cast are figments of the imagination. Back to Mac and Bloo, Mac has made a deal with Mrs. Foster to meet with Bloo everyday. It's even a plot point in some episodes.
* ''[[WesternAnimation/TheRenAndStimpyShow Ren and Stimpy]]'' are a textbook example of the trope DependingOnTheWriter. In the ill-fated revival series that briefly ran on Spike TV, Ren and Stimpy were actually a gay couple. WordOfGod says that their status depends on [[RuleOfFunny which is funnier]] for the specific episode, and the extent of Ren's contempt towards Stimpy seems to vary DependingOnTheWriter. Especially in earlier episodes, they're portrayed as a fairly normal pair of buddies, with little venom coming from Ren. Some episodes of ''Adult Party Cartoon'' show their relationship as a borderline type 1 of VitriolicBestBuds (like "Stimpy's Pregnant"), while others make Ren out to be rather tender and kind-hearted towards Stimpy ("Onwards and Upwards"). It happens in the original series too, though much more subtly ("Rubber Nipple Salesmen" for the first example, "Son of Stimpy" for the second).
* Stan and Kyle from ''WesternAnimation/SouthPark''.
-->'''Stan:''' I don't wanna hang out in the kids' room. I won't know anybody.\\
'''Randy:''' Well, it would be good for you to make new friends. You can't just hang out with your buddy Kyle all the time. People will think you guys are, you know, funny.
** Especially in the Guitar Hero episode.
--->'''Kyle:''' Don't you get it? I don't need you anymore!\\
'''Stan:''' I know. I need ''you''.
** Though not seen on the show much in later seasons, Ned and Jimbo qualify.
*** Although Jimbo [[ItMakesSenseInContext didn't get beeped for saying "fag"]]...
** Terrance and Phillip. They were once MistakenForGay. ''By Phillip''.
-->'''Terrance:''' Wow, Scott really hates us Phillip.\\
'''Phillip:''' Yes, perhaps he's homophobic.\\
'''Terrance:''' ...But we're not gay, Phillip.\\
'''Phillip:''' We're not?!
* And then there's Ace and Gary, the "Ambiguously Gay Duo"
** [[WordOfGod An audio commentary from the actors]] said that they thought the funniest outcome would be to have one of the Duo be gay, but couldn't agree on which one.
* In ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' all of the Mane Six could qualify, as at different times they're all shown hanging out with each other individually even when Twilight Sparkle isn't around.
** The three Cutie Mark Crusaders.
** [[ThoseTwoGuys Snips and Snails.]]
** Silver Spoon and Diamond Tiara, though the latter is kind of mean to the former sometimes.
** And, of course.. [[AscendedFanon Lyra and Bon Bon]]. Though [[https://derpicdn.net/img/view/2014/9/28/731431.png this scene]] from ''[[WesternAnimation/EquestriaGirls Rainbow Rocks]]'' seems to give a rather firm shove ''past'' heterosexual life partners.
*** There are plenty more such fanon pairings, such as Derpy Hooves and Carrot Top, for one.
* Norbert and Daggett of ''WesternAnimation/TheAngryBeavers''. Being brothers helps.
* ''WesternAnimation/{{Daria}}'': While there's never even any subtext of romantic involvement ([[spoiler:Jane's sexual questioning in ''Is It Fall Yet?'' notwithstanding]]), Daria and Jane otherwise fit this trope, especially the way Daria gets intensely jealous of Jane's boyfriends.
** The romantics angle is joked about by the show; one of the "Daria Day" marathon host segments features them as husband and wife, and in another host segment with Daria as a nude model, Jane cracks that she can paint Daria's ''form'' "from memory".
* Jimmy, Carl, and Sheen from ''WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius''.
* ''WesternAnimation/SWATKats'': Chance Furlong and Jake Clawson spend nearly ''all'' their time together, even at the salvage yard garage where they live.
* ''WesternAnimation/MyGymPartnersAMonkey'' has [[OnlySaneMan Adam Lyon]] and [[EverythingsBetterWithMonkeys Jake Spidermonkey]]. One episode even had them [[HoYay paired to take care of an egg in class]].
** Another has Jake ''publicly crying'' when Adam is absent for a day.
* ''WesternAnimation/{{Futurama}}'' had Fry and Bender. Bender is also extremely possessive and jealous, and gets angry/weepy when he can't live with Fry, or when Fry spends more time with his girlfriend than with Bender in the second movie. Sometimes expanded to Fry, Bender and Leela.
* The Canadian cartoon ''Kevin Spencer'' features the characters of Porn Man and Afro Man, who not only co-star in the adult films they act in, but also share a swinging bachelor pad. There's no HoYay between them, though, since they get more than enough action both in their day jobs and at the wild parties they host in their free time.
* The Platypus Brothers in ''WesternAnimation/TazMania''. To a lesser extent, Taz and Digeri Dingo since they've known each other since birth and Taz always goes along with Digeri's schemes. Why? "Taz like Dingo!"
* WesternAnimation/BeavisAndButthead (though in "This Book Sucks", it's explained that they're half brothers).
* Ami and Yumi in ''WesternAnimation/HiHiPuffyAmiYumi'' are like this. They live in the same dwelling...but it's a tour bus, which they travel the world in, along with their manager Kaz. Though there ''are'' times at which they appear to be a little too close not to be doing each other, they have both shown strong interest in men and [[NerdsAreSexy fought over a male nerd]], labeling them as bona fide Heterosexual Life Partners. (NoBisexuals?)
** After deciding they won't fight over boys anymore they hug under a rainbow. Make of that what you will.
* Stan and Koji in ''WesternAnimation/ObanStarRacers''.
* Diadoro and Gomez in ''WesternAnimation/ComboNinos''.
* ''Toot and Puddle'', two animated pigs starring in a program by the same name, based on a series of picture books, by the same name. Live together in a small home in the burg of Woodcock Pocket/Pocket Hollow and often travel together.
* Badger and Mole of ''AnimalsOfFarthingWood'' are inseparable and they often worry about each other when one of them goes missing with Mole being the most emotional about it often bursting into tears, in fact after Mole dies Badger just can't accept the fact he mistakes Mole's son Mossy for him as they look alike and he goes along with it because he was told it would break his heart he remains his companion until Badger passes away of old age.
** It was different in the books however. Badger never died, but Mossy did. Badger found the body and as such, it's pretty clear that he can't go into denial a second time.
* Virgil and Richie from ''WesternAnimation/StaticShock''. Helped along with the fact that it's been admitted that Richie is gay by the animators and in the original comic Rick, who Richie is based on, is gay and there is even an arc where Virgil deals with his feelings on the matter.
* Barbie and Teresa (and their story colunterparts Liana and Alexa) in ''WesternAnimation/BarbieAndTheDiamondCastle''.
* [[WesternAnimation/RockosModernLife Rocko and Heffer]].
* [[WesternAnimation/TheFlintstones Fred Flintstone and Barney Rubble]] are a popular example of this.
* ''WesternAnimation/TheVentureBrothers'' has Henchmen 21 and 24. 21 even lampshades this in a third-season episode, when The Monarch doesn't know who 24 is.
** "You know whenever you're talking to me, there's another guy with me? That's 24!"
** The "Jet Boy, Jet Girl" conversation.
** ''The Venture Brothers'' is nothing but Heterosexual Life Partners. Even if you don't count the aforementioned, plus the eponymous characters, you have Brock and Rusty, Pete and Billy, Tim-Tom and Kevin, Watch and Ward, Shore Leave and Mile High. And the creators of the show, who most of the characters are based on in some sense.
* Mac and Tosh otherwise known as the Goofy Gophers from WesternAnimation/LooneyTunes they are super polite to each other and agree with what the other says, many people have mistaken them for gay but in several cartoons they have fallen in love with female gopher disguises.
* [[WesternAnimation/YogiBear Yogi and Boo Boo]].
** Pixie and Dixie.
** Quick Draw [=McGraw=] and Baba Louie.
** Snooper and Blabber.
** Hokey Wolf and Ding-A-Ling.
** Peter Potamus and So-So
** Breezly and Sneezly
** ...and a number of others. Let's just say that this trope was a semi, if not regular occurence in Creator/HannaBarbera's shows.
* ''WesternAnimation/PhineasAndFerb'', a pair of inseparable (step)brothers. Also, from the same show, [[AnimalSuperhero Perry]] [[FriendlyEnemy and]] [[MadScientist Doofenshmirtz]]. (WordOfGod says they didn't want to give Perry a girlfriend because he's MarriedToTheJob--beating up Doofenshmirtz.)
** To a lesser extent, [[TheBully Buford]] and [[BollywoodNerd Baljeet]], whose bully/nerd relationship is portrayed more like a weird kind of friendship.
** It's worth noting that Buford and Baljeet's song "Frenemies", while more about their status as VitriolicBestBuds, includes such lines as "He's like my least favorite brother" and "We're Frenemies 'till the end."
** Candace and Stacy also count for this.
* Skwisgaar Skwigelf and Toki Wartooth from ''WesternAnimation/{{Metalocalypse}}'' are a fairly good example of this trope. While they constantly bicker over Toki's role in the band and Skwisgaar is just generally a {{Jerkass}} to him in almost all of their interactions, they often choose to hang out with each other exclusively and once in a blue moon they will come to the other's defense (Skwisgaar in "Dethrace", for example). They've also waxed philosophical together about subjects such as family and women (well as philosophical as you can get [[{{Gorn}} with]] [[RefugeInAudacity this]] [[CrazyAwesome show]]). Considering that Toki has stolen Skwisgaar's clothes [[ItMakesSenseInContext to emulate him in a Dethklok tribute band]], offered him a **** in exchange for not getting kicked out of the band, and dated a girl that looked ''exactly like a female version of Skwisgaar'', some fans would argue that Toki is or was actually nursing something of a [[{{Tsundere}} Tsundere-esque]] crush on him.
** It's worth noting that when Toki hangs out with another guitarist in Dethlessons, Skwisgaar's confrontation almost sounds like someone finding their spouse with another partner. And Toki's line "I've always hated you, Skwisgaar" in the first season finale is met with an almost ''affectionate'' sounding, "I knows, Toki. I knows." The previous line, in which Skwisgaar's post-mortem plans include hanging out with Toki in Valhalla. Often times they hate each other, [[VitriolicBestBuds but they're also incredibly dependent on each other]].
*** Every possible pair in the band can be taken this way, allowing for a certain amount of belligerence and the fact that all five of them are complete idiots, except for Pickles, whose intelligence is completely sublimated by his being constantly balls-to-the-wall high, drunk, or some combination of the two.
* Bobby and Joseph on ''WesternAnimation/KingOfTheHill''.
** Hank, Bill, Dale, and Boomhauer have these moments between each other. One episode (with an OverlyLongTitle) even dealt with a feud between Dale and Bill over a littered beer can being seen as a couple having marital problems.
* Poison Ivy and Harley Quinn in ''[[WesternAnimation/BatmanTheAnimatedSeries Batman TAS]]'', one of the few villain team ups that is based on friendship, rather than mutual gain. Though the WordOfGay probably strikes out the "heterosexual" part.
* In ''WesternAnimation/InvaderZim'', Red and Purple. An unfinished episode reveals they were hanging around each other even ''before'' being appointed co-rulers of the Irken Empire. One could also argue Zim and Dib, in a weird, twisted sort of way.
** Zim and Gir!
*** Or for that matter, Gir and Tacos.
* ''WesternAnimation/JimmyTwoShoes'' and Beezy Heinous.
* Chris and Chef Hatchet from ''WesternAnimation/TotalDramaIsland''.
** Even more so, Katie and Sadie, who take being "best friends" to a bizarre level. Lindsay and Beth develop a similar but more grounded relationship, especially in TDA.
** [[LargeHam Owen]] and [[DeadpanSnarker Noah]] also become this in TDWT.
* Russel Hobbes of Music/{{Gorillaz}} actually described his best friend Del as his soulmate - he was, since Del's ghost lived in Russel's brain for several years. Russel is the only one of the three living male band members who doesn't have numerous illegitimate offspring, and we've never heard about any women in his life, [[HoYay so, um...]]
** Murdoc and 2D show us what happens when Heterosexual Life Partners also happen to have an abusive relationship. [[ComedicSociopathy Usually this is played for laughs,]] though 2D's {{woobie}} status has grown in the latest arc. However, considering that Murdoc's strongly hinted to have some DepravedBisexual tendencies, the heterosexual part [[HoYay is a little open-ended]].
* Peri and Entrče from ''WesternAnimation/{{Spliced}}''.
* WesternAnimation/FanboyAndChumChum are two best friends who live together in a water tower with no parents whatsoever. Taken to the extent that the very stability of the fabric of the universe depends on them being together.
* Bill the duck and Aldo the alligator on ''WesternAnimation/SittingDucks''.
* Sokka and Zuko from ''WesternAnimation/AvatarTheLastAirbender'' seem to be headed this way, even though they didn't get a whole lot of on-screen interaction. To fanfic!!
** Arguably, Mai and Ty Lee as well.
** In ''TheLegendOfKorra''. it's basically stated that Aang and Zuko became this.
* Scooby and Shaggy in ''WesternAnimation/ScoobyDooMysteryIncorporated'', to the point that it prevents Shaggy and Velma from having an actual romantic relationship.
* Thrasher and Blastus in ''WesternAnimation/{{Robotomy}}''.
* Robin and Kid Flash in ''WesternAnimation/YoungJustice''. They have arguably the closest friendship on the show-- while the four original sidekicks were all good friends and they quickly accepted the new guys, these two were already best friends. While Franchise/{{Batman}} has told Dick not to reveal his secret identity to his teammates, he [[SecretKeeper told Wally anyway]]. In a show with "secrets and lies" as a central theme, these two stand out because even when Dick ''tries'' to keep secrets from Wally, Wally knows him too well not to figure it out.
** After the TimeSkip, [[KidFromTheFuture Impulse/Bart Allen]] actively attempts to cultivate this trope with Blue Beetle/Jaime Reyes...though it's revealed to be genuine when [[spoiler: Impulse reveals the exact reason for the attempt [[BadFuture the world he came from had been devastated by the Reach]] and it's been implied to be mainly because [[FaceHeelTurn Blue Beetle went bad]] and then proceeds to comfort Jaime when he is obviously [[FutureMeScaresMe terrified at the idea]].]]
* WesternAnimation/RockyAndBullwinkle.
* Mordecai and Rigby from ''WesternAnimation/RegularShow''. "Bros" in the standard definition, as they act like two college roomies.
* Finn and Jake from ''WesternAnimation/AdventureTime'', though raised as brothers, and referring to each other as 'brother', are this to a T.
* ''WesternAnimation/{{Recess}}'':
** Mikey and Gus seem to be the closest friends with each other out of the main six main characters, and often take each other's sides in conflicts.
** And to a lesser degree, T.J. and Vince.
** Outside the main six characters, you've got Sam and Dave, the diggers.
* Mark Lilly and Randall Skeffington in ''WesternAnimation/UglyAmericans''. Randall has a habit of getting pretty HoYay with Mark, much to his [[{{Squick}} discontent]].
* WesternAnimation/DangerMouse and Penfold.
* WesternAnimation/HeckleAndJeckle. The two even share the same bed in at least two cartoons ("The Power Of Thought," "Ten Pin Terrors").
* Sheriff Blubs and Deputy Durland from ''WesternAnimation/GravityFalls''.
* Dan and Chris from ''WesternAnimation/DanVs''.
* Steve Smith and "Snot" on ''WesternAnimation/AmericanDad''.
* Max and PJ on ''WesternAnimation/GoofTroop'' are extremely close friends. They do everything they can together in both the show and the movies, and they--especially PJ--often become very upset when they are separated. The few times their friendship is threatened (''always'' due to an interfering third party) one or both of them always put in a lot of effort to make sure they can stay friends. Their relationship is, [[WithFriendsLikeThese while not perfect]], structured on giving each other support, being honest with each other, and helping each other out of tough situations. They did both have a FriendlessBackground, and Max acted as PJ's LivingEmotionalCrutch, to which he responded with UndyingLoyalty ([[NoSympathy Max himself struggles with it]]). Interestingly, they are not at all upset when the other one gets a girlfriend--[[ShipperOnDeck quite the opposite]] in fact. By ''An Extremely Goofy Movie'', [[TrueCompanions they have added Bobby to the mix as well]].
* Ratty and Mole from ''WesternAnimation/MrBogus'' are a [[ThoseTwoBadGuys villainous example]] of this trope.
* Hack and Slash from ''{{ReBoot}}'' exemplify this trope. They are literally never seen on screen without one another. They even get blown up by Hex together. (Then Phong put them back together and reprogrammed them, hence their HeelFaceTurn.)
** Also Dot and Mouse, as well as Enzo and Frisket. Bob and Matrix also become this when they meet up again in season 3.
* ''WesternAnimation/ThomasTheTankEngine'': Thomas and Percy have become this, most especially in the later seasons. Gordon and James can also count, especially in the earlier seasons.
* Mike Chilton and Chuck from ''WesternAnimation/{{Motorcity}}''. They call each other "Mikey" and "Chuckles" at time and Mike always has his back for Chuck, as the latter is the CowardlyLion / NonActionGuy. Chuck does manage to go out of his way for Mike in "Fearless" though.
* Randy and Howard from ''WesternAnimation/RandyCunninghamNinthGradeNinja'' have this, having been inseparable since childhood and even being close enough to share each others underwear.
* [[TheDitz Vinnie]] and [[LovableCoward Sunil]] from ''WesternAnimation/LittlestPetShop2012'', especially since the second season. They often watch horror movies together [[HoYay with plenty of]] [[SecurityCling Security Clinging]].
* And last, but perhaps most importantly, ''WesternAnimation/TimonAndPumbaa''.
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