* [[VideoGame/{{inFAMOUS}} Zeke and Cole]], especially in ''VideoGame/{{inFAMOUS 2}}'', are pretty much the epitome of this trope in video games so long as you choose to be a hero.
* ''[[ArTonelico2 Ar Tonelico 2: Melody of Metafalica]]'' - [[spoiler: Luca and Cloche wind up this way, particularly in the Jacqli and Cocona endings.]]
* ''Franchise/MassEffect'' has Garrus Vakarian and male Shepard, as well as Tali'Zorah and female Shepard. And in the truest expression of this trope, they are both romancable in the second and third games when Shepard is the opposite sex. The fact that they hook up with ''each other'' if you don't, says something about the trio as a whole.
* Many, due to the [[LoadsAndLoadsOfCharacters size of the cast]] in ''StarWarsTheOldRepublic'', but some fit better than others:
** Female Agent and Kaliyo is probably the best example.
** Female Smuggler and Risha.
** Male Trooper and Jorgan, or female Trooper and Elara.
* The title characters in the video game spinoffs of ''[[SamAndMaxFreelancePolice Sam & Max: Freelance Police]]'' as produced by first Lucas Arts and then Telltale Games are marked as heterosexual life partners on many occasions.
** In ''SamAndMaxHitTheRoad'', one scene has the two going into a "Tunnel of Love" ride.
-->'''Sam:''' Want to go in the tunnel of love?\\
'''Max:''' Yippee!!
** When Sam and Max are separated in "Culture Shock", Sam actually starts to hallucinate from withdrawal.
** [[LampshadeHanging Lampshaded]] in "Abe Lincoln Must Die!", where according to Sybil's "compatibility test", their soul mates are each other.
** In "Chariots of the Dogs", a woman develops a crush on Max, and when Sam objects (because the woman in question is Bosco's mother, and that would cause a TimeParadox), she seems to assume he's gay, and "wants to keep [Max] all for himself".
** In "What's new Belzeebub?", when Sam tells Max that [[spoiler:Demon Peepers]] claims to be his new best friend, Max ''rips out [[spoiler:Demon Peepers']] kidneys''.
** But probably the most iconic example is in "They Stole Max's Brain!" when Sam, believing Max has been murdered, goes in a RoaringRampageOfRevenge, [[CrowningMomentOfAwesome stylized as a film Noir hard-boiled detective mystery]], using JackBauerInterrogationTechnique in every suspect to figure out, well, [[ExactlyWhatItSaysOnTheTin who stole Max's Brain]]. He even threatens friends at Gun Point to obtain information! He gets a lot better when he know Max is okay though.
** This is highlighted [[TearJerker tear-jerkingly]] well in "The City That Dares Not Sleep" when [[spoiler: Max does die. Instead of going on a rampage, however, Sam simply... loses hope. As the credits roll, we see Sam walking dejectedly through the streets of New York. Luckily, a Max from a universe where ''Sam'' dies appears. The two seem to agree to use the other as a ReplacementGoldfish]]. They then go out to stop more crime.
** If you think the video games are Ho Yay suggestive, check out the animated series, and it was for kids.
* Liu Kang and Kung Lao as well as Jade and Kitana in ''MortalKombat''. In fact, Kitana and Jade claim to have been friends all their lives, and both are around [[Really700YearsOld ten-thousand years old]], taking this Trope UpToEleven. (Some fans tend to think [[LesYay there's a little more to it than that.]]
** There's also Sub-Zero ([[LegacyCharacter the younger brother]] from ''2'' onward) and fellow [[McNinja Lin Kuei]] Smoke. According to ''Deception'', there's also Sub-Zero and Kenshi, as well as Ermac and Kenshi.
* [[{{Uncharted}} Nathan Drake]] and Victor Sullivan seem to fit this pretty well, and Sully also acts as the mentor type figure for Nate.
* Gumshoe ''thinks'' he has one of these going on with Edgeworth in ''Ace Attorney''. Sometimes it's truer than others. Edgeworth does seem very fond of him, and has saved him from getting fired on several different occasions. But he's still very frequently annoyed by the bumbling detective.
** Phoenix and Maya '''do''' have [[PlatonicLifePartners something similar]] going on, despite their sexual compatibility and what [[ShipperOnDeck Pearly]] would have you think.
** It's arguable that Phoenix and Edgeworth have a bit of this going on, on the rare occasion that they openly cooperate. Of course, being on opposite ends of the courtroom, this is usually more of a case of [[{{HoYay}} Heterosexual]] [[{{VitriolicBestBuds}} Life Rivals]], but as they are ChildhoodFriends who have repeatedly helped each other out of very tough situations, they certainly have a strong mutual understanding of one another at the very least. But then again, the rampant ShipTease (Ace Attorney 5 even gets its own brief ShipperOnDeck scene) and widespread {{Fanon}} interpretations don't help their case much.
* X & Zero in the ''VideoGame/MegaManX'' games, who were originally created to kill each other. By ''VideoGame/MegaManX5'', the HoYay was waist-deep. It doesn't help that Zero ''looks like a girl.''
** The ''[[VideoGame/MegaManBattleNetwork Battle Network]]'' series give us Lan and [=MegaMan=].EXE and [[VideoGame/MegaManStarForce Geo and Omega]], though it's somewhat padded by them having other friends as well.
*** Then again, in Lan's and [=MegaMan=].EXE's case, they've been pulling each others' asses outta frying pans for as long as the series has run. [[spoiler:[=MegaMan=] is Lan's dead older twin brother Hub, resurrected as a digitized ReplacementGoldfish by their father.]] So their bond is pretty justified.
* [[MemeticBadass Sanger]] [[EverythingsBetterWithSamurai Zonvolt]] and [[CharClone Elzam]] [[SupremeChef Branstein]]/[[PaperThinDisguise Ratsel Feinschmeker]] in the ''VideoGame/SuperRobotWars'' franchise. The jokes only get worse when Elzam gets a HumongousMecha that transforms into a horse [[Memes/VideoGames to be ridden by Sanger's mech]]. [[HoYay Real Men Ride Each Other]], indeed...
* ''VideoGame/{{Xenosaga}}'': Shion and [[spoiler:Mary Magdalene.]]
* If you really feel that you absolutely have to, you could treat Snake and Otacon in ''Franchise/MetalGear'' as HeterosexualLifePartners. But you would know that you are just [[HoYay/MetalGearSolid lying to yourself]].
* Marcus Fenix and Dominic Santiago from the ''GearsOfWar'' franchise, to the point where Dom will break into an abandoned prison filled with subterranean mutants in order to free Marcus. And sure, Dom's got a long-lost wife, but [[spoiler:she conveniently dies during the second game.]]
** During a podcast from before ''Gears 2'' was released, the staff of GiantBomb commented that they wanted to see the game end with a passionate kiss between Dom and Marcus, if for no other reason than to [[TakeThatAudience annoy the legions of]] [[{{Noob}} foul mouthed 12-year-olds]] who play ''Gears'' on Xbox Live.
* Luis Lopez and Gay Tony from Grand Theft Auto DLC "The Ballad of Gay Tony". Now, admittedly, Gay Tony is, well, Gay. But that doesn't stop Luis and Tony from having a close, yet strictly platonic friendship. Luis the muscle and Tony the plan maker (Even if he's not a very good plan maker) They compliment each other's character development well. Both characters need each other. Tony helps Luis get back on his feet and teaches him business sense and Luis keeps Tony safe and his head on straight once he begins to descend into a drug bing. Friends that close are rare to find
* Because they are the most famous Uber pairing in the game, the Medic and the Heavy from ''VideoGame/TeamFortress2'' can be described as hetero life partners. (The {{slashfic}} writers would disagree, but there you go.)
-->'''The Heavy''': I ''love'' this doctor!
** While every class has variations of "Thanks, doctor!" and "Follow me, doctor!", the Heavy seems the most enthusiastic. In addition, he has several lines boasting about the fact that "his" doctor is still alive. The Medic's lines are more generic ("Ve did it, camarade!"), but the fact that many Medic players follow Heavies almost exlusively would seem to confirm the hetero-life-partner relationship, if only in Fanon.
** The BLU Soldier and RED Demoman had one of these going on before the Administrator broke them up.
** [[http://www.teamfortress.com/truemeaning/ And the close companionships continue.]]
*** This one is [[FridgeBrilliance in particularly brilliant, as any Engineer will tell a Pyro is their best friend.]]
* Sora and Riku from ''Franchise/KingdomHearts''. Sora reacts with such heartfelt gladness over Riku's return in the second game that it overshadowed his reunion with his nominal love interest Kairi. It was obvious enough that one webcomic artist did [[http://www.vgcats.com/comics/?strip_id=208 a parody of the scene]][[note]]Possibly justified in that the last time Sora saw Riku was probably a year and a half prior, and he had been trapped in the Realm of Darkness. Riku could've been dead for all he knew, and they've known each other for their whole lives. Kairi on the other hand, was just kidnapped, and since she was only in the castle to give Sora a little extra motivation for killing Heartless, he knew she'd be safe.[[/note]]
** Roxas and Axel, depending on your interpretation.
** Saix and Axel were shown to have had this dynamic from their time as a somebodies (Isa and Lea) up to them joining Organization XIII. [[spoiler:It's too bad that their friendship suffered when Saix [[BecomingTheMask became too caught up in being]] Xemnas' [[TheDragon Dragon]]...]]
** Another possible example: Zexion and Lexaeus, as seen in ''Chain of Memories''. They're [[BadassBookworm intellectual]] [[GeniusBruiser equals]] and often conduct civil, sophisticated conversation in each others' presence. The latter even goes as far as to silence [[SmugSnake Vexen]] when he becomes too condescending towards Zexion over his rank. Lexaeus' Secret Report in ''Days'' even says that Zexion's [[TheOnlyOneITrust the only one he can trust]], and Lexaeus is shown asking for Zexion's forgiveness when [[spoiler:an "Ansem"-possessed]] Riku kills him. When the two of them regain their humanity in ''3D'', they are seen in the same room where Lea wakes up. Everyone else seemed to have gone elsewhere, but those two are good pals enough to not be separated.
* Reno and Rude of ''VideoGame/FinalFantasyVII'' and its spin-offs fit the bill.
** [[VideoGame/CrisisCore Genesis Rhapsodos and Angeal Hewley]] could also fit--Angeal ditches the organization he's worked for for who knows how long for Genesis, so they must be some damn good friends at least.
** Arguably, Cloud and Zack. Zack even looks after the comatose Cloud and even died defending him against hundreds of Shinra soldiers.
* Yuna and Rikku in ''VideoGame/FinalFantasyX'' could be said to be this, seeing as they formed the [[VideoGame/FinalFantasyX2 Gullwings]] together after the first game.
** One could also make an argument for [[PowerTrio Jecht/Braska/Auron]] as well. [[spoiler: So much so, in fact, that when Jecht becomes [[EldritchAbomination Sin]], Auron essentially acts as a godfather for Tidus and is the one person shown to be able to speak to Sin, which sets the plot in motion.]]
* Even though they don't last a life time, the King of Red Lions of ''VideoGame/TheLegendOfZeldaTheWindWaker'', Ezlo from ''VideoGame/TheLegendOfZeldaTheMinishCap'' and Linebeck from ''VideoGame/TheLegendOfZeldaPhantomHourglass'' could easily fit as Link's partners.
* Well, more this one involves than two perhaps, as [[VideoGame/StarFox Star Wolf]] is a trio of male mercenaries who have shared their lives together, being Wolf, Leon and Panther. Also, it is hinted that Wolf and Leon have been together longer, going way before the events of Star Fox 64...though well...Leon seems to be enjoying his partner for [[FetishFuel sadomasochism]].
* [[Franchise/SonicTheHedgehog Sonic]] and Tails.
** The Team Chaotix members, especially Vector and Espio. Considering that this couple is also arguably the most popular homosexual couple amongst the minor characters (that is, outside of Sonic, Tails, Knuckles, Amy, Shadow and Eggman), this definitely overlaps into HoYay territory, for the fans.
** ''SonicTheComic'' had Tekno and Amy. [[LesYay Most Likely]].
* Shinon and Gatrie from ''VideoGame/FireEmblem: [[VideoGame/FireEmblemTellius Path of Radiance]]'' and ''Radiant Dawn''. Played for laughs, as [[CasanovaWannabe Gatrie]] is forever LookingForLoveInAllTheWrongPlaces, and [[TallDarkAndSnarky Shinon]] regularly points out that the girls are either only interested whatever little money he may have or wholly unattanaible.
-->'''Gatrie''': "Don't mock me, Shinon! This is serious. I feel it. It's destiny! That girl and I are fated to be together!"
-->'''Shinon''': "You're chasing after a [[FantasticRacism laguz]] now? Gatrie, I swear you'd hit on a tree if I dressed it in a skirt. Tell me I'm wrong!"
** Most ''Fire Emblems'' have a pairing like this. ''[[VideoGame/FireEmblemElibe Sword of Flame]]'', for example, has Kent and Sain. The pairing of two Cavaliers, such as this one, is especially common, as we also have Forde and Kyle in ''[[VideoGame/FireEmblemTheSacredStones Sacred Stones]]'' and Lance and Allen in ''[[FireEmblemElibe Binding Blade]]''. ''Binding Blade'' has a non-Cavalier example, too, with the Fighter pair, Ward and Lott (probably the better example from ''Binding Blade'', actually).
** Also, [[VideoGame/FireEmblemTellius Ike and Ranulf]], though Ike's heterosexuality may be debatable. Especially considering that Elincia flirts with him relentlessly, and he ignores her along with every other woman who shows possible interest, and in between games she moves on both [[TheWomanWearingTheQueenlyMask handling Crimea as best as she can]] and, if the player wishes so, possibly reciprocating Geoffrey's BodyguardCrush on her. He could be utterly disinterested in romance of any sort [[{{Asexuality}} from either sex]], but arguments still persist over whether Ike's [[RelationshipValues paired endings]] are this trope or all [[GayOption Gay Options]]. It might be of interest that neither Ranulf nor Soren show any romantic interest in women either.
*** It's obvious that Soren is very attached to Ike (and crosses the line into HoYay quite often) since Ike was his first [[spoiler: and according to Soren, his only]] friend. Ike respects Soren deeply, can sense his feelings unlike anyone else can, and is more than willing to let Soren cry on his shoulder when he starts [[DefrostingIceQueen breaking down about his past]]. They [[spoiler: end up leaving on a journey together in ''Radiant Dawn'' if they have an A-support.]] Both get rather upset when the other dies or is injured in battle, although Soren more so. Hell, if Soren dies, he makes clear with his last words that he places more importance on Ike's life than the fate of the world. [[AmbiguouslyGay Yes, very close.]]
---->'''Soren''': "Ike? Ike! This can't...It can't...What am I...If you're not here, what am I to do?"
** A female/female example comes in FireEmblemAwakening, with [[TomboyAndgirlyGirl Sumia and Cordelia]]. Their friendship is so strong that, in a DLC chapter, Cordelia almost gets into a CatFight with Maribelle over which girl has the best female friend. Not to mention, their ''possible'' [[LoveTriangle shared feelings]] for Prince Chrom ''never ever'' are an issue between them - Chrom's not even ''mentioned'' in their supports, [[TheBechdelTest which are all about their own bonds.]]
* ''WorldOfWarcraft'' has Asric and Jadaar, two [[VitriolicBestBuds perpetually bickering ex-cops]] who have moved from Shattrath City, to the [[AbsurdlySpaciousSewer Cantrips and Crows tavern under Dalaran]], to their current post at the Argent Tournament grounds since their first introduction. [[HoYay Speculation abounds]] about them.
** There's also Thassarian and Koltira, two death knights who were close friends even when they served under the Lich King. And Varian and Bolvar, who were "like brothers"; Bolvar is even something of a father figure to Varian's son and helped raise him.
** Tarenar Sunstrike and Gidwin Goldbraids from the Cataclysm expansion. Also known as "The Paladin Pals". While they bicker... quite a lot, their friendship is so strong it survived the fact that Tarenar is a Horde aligned Blood Elf and Gidwin is a Dwarf and part of the Alliance and when Gidwin's impatience gets the better of him and he winds up risking becoming a Death Knight Tarenar drops everything to go rescue him.
** Anren Shadowseeker and Tholo Whitehoof in the Firelands content. After one quest Tholo even says, "Anren and I might no longer face the terrifying risk of being separated from one another." D'aww!
* The main character and Yosuke in ''VideoGame/{{Persona 4}}'' definitely have shades of this if you develop Yosuke's social link. In point of fact, a FanNickname for Yosuke is Brosuke. The two later refer to each other as partners in ''Persona 4 Arena''.
-->'''Yosuke''': There's still nothing here, but I have family and friends...and you.
** Let's not forget Chie and Yukiko. According to the anime, both have known each other since they were little - it's all thanks to a dog.
** [[TheChick Yukari]] and [[TheOjou Mitsuru]] in ''{{Persona 3}}'' share a lot of this as well.
* In ''VideoGame/DevilSurvivor'', Atsuro is, in spite of the game's alignment-based structure, the one party-member who will follow you no matter what.
* Touka and Karura after the final boss fight in {{Utawarerumono}}. Unfortunately for any yuri fanboys out there, they're confirmed to still be hetero, as their mutual berserk button is disrespecting their relationship with Hakuoro.
* Ryu and Ken from the ''StreetFighter'' franchise. Guile and Charlie may count too.
** Alluded to in Wreck-It-Ralph after a day of beating each-other up. Ryu and Ken act totally buddy/buddy and go off to get drinks together.
* ''JakAndDaxter'' fit this trope to a tee, including the [[YaoiFangirl unwarranted]] {{Shipping}}. Never mind [[BalefulPolymorph Daxter]]'s [[{{Squick}} form]].
* RatchetAndClank are also this. In fact, the "life" part is very literal, having been together for nearly the same amount of time that Clank has been conscious. Also within the series are Qwark/Skrunch, Rusty Pete/Captain Slag (although, being pirates, they may not be ''heterosexual'' life partners), and Cronk/Zephyr.
* Captains Price and [=MacTavish=] have fitten into this one in the ''CallOfDuty ModernWarfare'' series.
* Rios and Salem in ''ArmyOfTwo''.
* Spyro and Sparx. In the backstories for both the original series and the Legend of Spyro series, they were born on the same day and are inseparable, especially since Sparx functions as Spyro's health meter.
* A female player character and Dawn Star in ''JadeEmpire''.
* Possibilities abound in ''NeverwinterNights''; any henchman can serve as this if you are the same gender, though Nathyrra/female player and Valen/male player are the best examples.
** Various fan-made expansions have examples; your character and your henchman (if same-sex) in the Shadowlords arc definitely qualify, as can the player and Llomir in A Hunt Through the Dark (depending upon your interpretation). A Hunt Through the Dark also has the AmazonBrigade Company of the Catlash, which probably counts.
* The player and Carth or Bastila in ''KnightsOfTheOldRepublic''.
** In the fanfic, it's also rather common for Canderous and Carth to come to this - despite the fact they probably ''did'' face each other from across a battlefield or two.
* In the origin stories in ''VideoGame/DragonAgeOrigins'', the Mage, Dwarven Commoner, and Dalish Elf each have HeterosexualLifePartners (well...however you take it, depending on the {{PC}}'s gender) who also serve as their partners during the beginning of the game. However, they're pretty quickly forced to leave them behind when they're the only one recruited into the Grey Wardens. Depending on how the player plays their cards, they can always find another one later on in a party member, especially noticeable with a male Warden and Alistair or a female Warden and [[GayOption platonic!]]Leliana.
** A female warden can also form this kind of bond with Morrigan (she at one point refers to you as not just a friend, but a sister), but it comes with a large side of VitriolicBestBuds. This is especially obvious if you tend to be more good-aligned or are romancing Alistair.
* The ''countries'' Canada and USA in ''ERepublik'' have a treaty that says they will "never give up on each other, never let each other down, and never run around or desert one another."
** ... did I just get {{rick roll}}ed by a treaty?
* Ralf and Clark in ''VideoGame/TheKingOfFighters'' (and their series of origin, ''IkariWarriors'').
* ''VideoGame/DragonAgeII'' has many possibilities, especially prominent with Male!Hawke and Varric. The fact that Varric is the only squad member who isn't your sibling who you can't at least flirt with helps.
** Also the fact that Varric is the only character who absolutely has to be in your party all the way through. You can [[spoiler: kick Anders and Merrill out of the party, kill Anders for blowing up the chantry, send Fenris back to slavery, hand Isabela over to the qunari, and get rid of Aveline by siding with the mages. You can't avoid losing your sibling. But you can't get rid of Varric!]]
* Male Commander Shepard in ''Mass Effect'' and quite a few of the male squadmates. Mostly in Garrus as he's a recurring member, but also in Wrex, Jacob and Thane and Kaidan, and Tali with a female Commander Shepard.
* Yui and Mako in ''LuxPain''. [[spoiler: It makes Mako's death really **** Yui.]]
* LivePowerfulProBaseball's every success modes from the forth game including MLB Power Pros' have you work with a funny guy with large glasses (usually Yamada or Marvin) who is likely to be your best friend, roommate, and your personal ChewToy.
* It wouldn't be too much of a stretch for Yuri Lowell and Flynn Scifo from VideoGame/TalesOfVesperia to be this. Flynn [[spoiler: sent out dozens of ships to look for Yuri after he fell from Zaude]] and Yuri would trust Flynn with his own life [[spoiler: to the point where he actually offers his life for Flynn's when Flynn is arrested.]] This usually falls straight into, well, [[{{Shipping}} you know]]...
** Rita and Estelle develop a very close friendship over the course of the game, and the stills in the credits seem to imply that they eventually become this, as they appear to be either visiting each other or living together in Halure. The only contention is [[LesYay they]] [[PortmanteauCoupleName have]] [[{{Tsundere}} even]] [[ShipperOnDeck more]] [[SayMyName romantic]] [[SheIsNotMyGirlfriend subtext]] than Yuri and Flynn.
* Jade and Peony in ''VideoGame/TalesOfTheAbyss''. Jade is Peony's unofficial right-hand man. Peony's named a rappig after him, they're childhood friends, and Peony seems to be the only person on the planet who can out-snark Jade. He also occasionally calls him [[HoYay "my" Jade,]] but, uh, don't think too hard about that. Peony's [[spoiler: in love with Jade's sister, we swear.]]
** Luke and Guy from the same game would also probably fit the bill. Guy has been serving Luke since they were both very young, and he is the only one who [[spoiler: goes back for Luke after Luke destroys Akzeriuth.]] You can even get a scene were Guy swears his UndyingLoyalty to Luke.
* ''GoldenSunDarkDawn'' shows this to be Isaac and Garet's relationship. They live in a cabin away from any settlements, their wives are nowhere in sight, they raised their sons together, and they spend the entire opening sequence acting LikeAnOldMarriedCouple.
* Sonny and Veradux of the flash game series ''VideoGame/{{Sonny}}'' are definitely this, at least by game 2, where during the opening cutscene Vera shows genuine concern when Sonny has a flashback to the events that started the first game (part of which is a tutorial if you choose to play it when starting a new game in 2), and is quickly on his feet with his weapon at the ready when Felicity decides to use Sonny as a parking space for her motorcycle, but he gets a knife thrown into his face before he can fire a shot. In the first game, this trope gets lampshaded in dialogue the pair share at the beginning of the final zone of the main story:
--->'''Sonny''': So how long do you plan on travelling with me?
--->'''Veradux''': 'Till death do us part?
--->'''Sonny''': [[SarcasmMode You're hilarious]].
* Gomar & Shioh from ''VideoGame/{{F-Zero}}''. [[http://www.youtube.com/watch?v=cz3KMusYsWs We swear they're getting married to Women soon. They're not gay at all.]]
* ATLAS and P-body from ''VideoGame/{{Portal 2}}'' can be considered an asexual example of this trope (although some fanartists depict them as being male and female).
* In ''VideoGame/TheReconstruction'', Dehl and Qualstio have shades of this. Justified, since when Dehl came from the mainland, [[spoiler:he had just witnessed his entire family being killed, and had only an infirm Moke for companionship. Qualstio helped him and gave him shelter at the first opportunity, and so he's practically the only family substitute Dehl's had for a decade.]]
* [[SuperMarioBros Mario and Luigi]] are brothers. This trope still applies, however, with the two's interactions.
** Indeed, as either of them spring into action when Peach is kidnapped, they show large amounts of concern and anxiousness and act even faster when one something happens to one of them.
** And from the same universe yet different game series, [[Franchise/DonkeyKong Donkey and Diddy Kong]]. When Donkey's banana horde is stolen, Diddy jumps at the call to help him. When K. Rool captured Donkey, Diddy got his own entire game just to help Donkey (granted, he had help from his girlfriend). It got so bad that K. Rool had to capture them BOTH by the 3rd game.
* In ''VideoGame/TheLegendOfDragoon'' Dart and Lavitz. While the amount of time they know each other is limited [[spoiler: due to Lavitz being killed by Lloyd with a Dragon Buster Sword]], the level of their friendship is obvious. There are several scenes throughout the game, including the closing scene, that highlights this.
* English Language StarCraft II commentators Tasteless and Artosis often act like this. They have a Portmanteau Couple Name, Tastosis, and they refer to themselves as the "Casting Archon" Archons being a Unit from StarCraft that is made of two other units that literally mold together. Tasteless even calls Artosis his "Hetero-Nerd-Life-partner"
* Adol and Dogi from the ''VideoGame/{{Ys}}'' series. They met in the first game and have been travelling companions pretty much ever since.
* Valvatorez and Fenrich from ''VideoGame/{{Disgaea 4|A Promise Unforgotten}}'' could very well be considered this. Although, calling them heterosexual may be giving them [[AmbiguouslyGay too much credit]]...
* Ezio Auditore and Leonardo Da Vinci in the Assassin's Creed II games pretty much function as this. Bro-hugs and sentimental moments abound. It's honestly probably the most touching relationship across all five games.
* Marisa and Reimu from the {{Touhou}} Project. The spinoff manga in particular tend to show Marisa spending more time at Reimu's shrine than at her own house. Those who know the characters primarily through FanWorks might be surprised at how ''little'' LesYay there actually is between the two of them.
* VideoGame/{{Fallout 3}}: Amata and the female player character.
* The hero and their partner in each game of the ''VideoGame/PokemonMysteryDungeon'' series always end up forming this sort of relationship. They're almost never seen apart once they meet and share a home in the latter two games of the three.
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