* In ''Manga/{{Akira}}'':
** The sound the burst and sweeping cooling pipes make once Akira's chamber bursts out of the sound. The fact there is next to no other sound in the background, and the visuals and audio makes it clear it happens in the background and the sound ''really'' carries leaves both the characters and viewers in awe.
* The [[DistressCall roars]] of the [[MoreDeadlyThanTheMale Female]] Titan in ''Manga/AttackOnTitan''. Every single person that hears it is either shocked speechless or terrified. Sasha compares it to the screams of a cornered animal, warning the others that something horrible is about to happen. She's right.
* ''Manga/AxisPowersHetalia'': Whenever Russia is angry, he'll chant KOLKOLKOL in a decidedly creepy fashion.
* ''{{Berserk}}'': In the anime during the Eclipse the sound of Guts hacking at his arm to break free of a demons jaws with his broken sword.
* ''Manga/BlackButler: Make it out of silver and gold, silver and gold, silver and gold. Make it out of silver and gold, my fair lady.''
* ''Manga/{{Bleach}}'' has the sound of Shinji's Cero blast. In addition to killing the music, it's incredibly jarring and unnatural. Best of all, the scene repeats itself in the next couple of minutes so you can experience it all over again.
** All Ceros sound like that. They just don't interrupt the music like Shinji's.
** Barragan's Respira has a creepy crackling sound that sounds like breaking bone.
** Konjiki Ashisogi Jizo, when first released, opens its eyes to the sound of a baby crying.
* Although ''{{Claymore}}'' may have fallen short on fan expectations compared to the manga, Masanori Takumi was [[http://youtu.be/x8l7aKF5Xh0 incredibly good]] at making [[http://youtu.be/HnmoxTcW7Ao music that made you visualize]] just how evil the youma were.
* Occurs in ''Manga/DeathNote'' whenever Light goes into Kira mode, accentuated with his creepy little giggles.
* In ''Manga/DragonBall'', Videl expects to make it to her match with Gohan relatively easily, as does the in-series audience. For the next two episodes, we are treated to her opponent of her current match, Spopovitch, brutally torturing her in one of, if not the most horrifying fights in the series.
** Also, some of Chi-Chi's outbursts (has she ever heard of speaking calmly?). You'll want to turn down your volume because you'll have a massive headache even ''after'' she stops yelling.
* Junji Ito's ''Manga/TheEnigmaOfAmigaraFault'' is the one that will stick with you forever. ''DRR DRR DRR...''
** [[http://1d4chan.org/wiki/File:Ddrddrddr.jpg Here]]'s some NightmareRetardant for you poor souls. [[spoiler: DDR DDR DDR...]]
** [[NightmareRetardant "It's slowly coming this way!"]]
* ''Manga/FullmetalAlchemist: Brotherhood'' has the blood-curdling scream of [[spoiler:[[NightOfTheLivingMooks the just-awakened mannequin soldiers]]]]. Knowing the context of their existence can only make this even worse.
** [[EvilLaugh Father's laugh.]]
* In episode 11 of ''GhostStories'' there's the sound of a lot of phones ringing all at once and the voice of Mary, a talking CreepyDoll.
* The train whistle in ''Anime/HaibaneRenmei''.
* ''{{Hellsing}}'s'' sound of Rip Van Winkle's alarm clock ringing continuously in the fourth OVA, shortly before Alucard smashes it.
* ''HigurashiNoNakuKoroNi'': All the time. A recurring noise is something that sounds like a blade slicing through the air, and you can hear a similar metallic vibration.
** One common symptom of having fallen victim to the curse of Oyashiro is hearing a disembodied voice saying "I'm sorry, I'm sorry..." and footsteps.
** Moments when any of the characters engage in some laughter or start screaming. Which is often.
** The cicadas. Oh God, the cicadas...
** The sounds of Shion's [[{{Fingore}} nails getting ripped out]] coupled with her screams of insanity.
** The VisualNovel also has a sound that sounds close to [[ScareChord something screeching to a halt with a loud heartbeat immediately after]] whenever something very unexpected or terrifying happens.
* The terrifying gambling drill from ''{{Kaiji}}''; a device that attaches into one's ear, with a drill that advances a set number of millimeters whenever a bet is lost. It's said that the noise it makes is minimal, but because of the strategic location of the machine AND the psychological pressure put into the gambler, the sound of the drill steadily approaching to destroy one's eardrums is a soul-crushing torture on itself.
* ''Anime/MawaruPenguindrum'': Ribbit. ''Ribbit''. '''Ribbit'''. '''''RIBBIT'''''. Made even worse because the one that makes it... is none other than [[spoiler: '''Tabuki''']], of all people.
** After episode 15, any kind of [[spoiler: chiseling]] noises may make you want to scream and run for the hills. Poor, ''poor'' [[spoiler: Yuri]].
* The sound of [[{{Yandere}} Yuno's]] voice in the ''MiraiNikki'' anime when she screams ''Akise Aru...You're...dead!" after she sees him kiss Yuki.
* ''{{Anime/Monster}}'': Occurs at some point during each episode, especially whenever [[TheDreaded Johan Liebert]] makes an appearance.
* ''Manga/{{Naruto}}:
** Orochimaru's "Ku-fu-fu" and his [[http://www.youtube.com/watch?v=DyLuQ0t-DXc girlish giggling]].
** Kisame's sword Samehada gets in on this trope in the chapter where it [[spoiler: gains a mouth.]] '''Samehada''': "Gi Gi Gi Gi..."
** Naruto's 4-tailed form (and 6-tailed) not only [[BodyHorror looks like a hell-beast]], but he emits a throaty growl ''exactly like the Kyuubi itself,'' and when you consider that he is human-sized in these forms, and that the lesser forms do not alter his voice...
** The '''''lovely''''' blood-curdling screams of the massacred Mist-nin during Obito's rampage as well as his primal screams, reminiscient of a screeching beast definitely counts.
* ''Anime/NeonGenesisEvangelion'' has enough examples to fill an entire page:
** There's an unsettling Train Crossing sound-effect that's heard during Shinji's Personal Hell Introspections (which tend to feature trains), during Asuka's MindRape sequence after she spots Shinji behind Kaji, as well as during the "Breakup" lines Psychological sequence in the second part of ''EndOfEvangelion''.
*** The second you hear "''TWANG-TWANG-twang-twang-twang-twang-twang-twang-TWANG''", you know that someone's mind is not entirely in the right state.
** When a distorted, guttural, growling noise, like the synthesis of circuits and synapses, is heard during sync sequences (and behind the incoming Harpies), one knows everything is about twenty seconds away from going all to hell.
** When you hear the cicadas, something bad is going to happen.
** The piercing ''BEEEEEEP'' that announces that the Eva unit has run out of internal power. ''Oh... shit.''
** The moo-like bellow when [[spoiler:Unit01 goes berserk and eats an Angel]]. We hear it again in the background during Asuka's MindRape.
* The sound of Kuma pushing someone somewhere in ''Manga/OnePiece'' especially considering what happened to the crew. Less so now, due to recent revelations.
* ''{{Paprika}}'': A buzzing sound can be heard when a CreepyDoll is first shown in what appears to be the real world, or when Paprika sees Tokita asleep.
* ''Anime/PuellaMagiMadokaMagica'' combines this with GoryDiscretionShot when [[spoiler:[[EldritchAbomination Charlotte]] devours Mami's body]]. In the manga, this trope is, for obvious reasons, averted. [[NauseaFuel Unfortunately]], so is the GoryDiscretionShot.
* ''RebuildOfEvangelion'' has Ramiel ''shrieking'' when it attacks. Which is awesome, but also creepy as hell.
** Not the first time Gainax has used that particular sound effect. It was used for the [[spoiler:Real Space Monsters]] in {{Diebuster}}. Which makes it no less terrifying.
* ''Anime/RevolutionaryGirlUtena'': In the shadow girls' plays there's a borderline GoryDiscretionShot when one of the shadow girls breaks the other one in half. A disturbingly realistic squishy, snapping sound is included, of course.
** In the movie version, the revelation of [[spoiler:Anthy's scar]] during the nude sketching scene is made all the creepier when you can hear what sounds awfully like a ''dentist drill''.
** The sound of the Ohtori academy bell at times.
** [[MadnessMantra "Deeper... go deeper."]] Goddammit, [[spoiler: Mikage.]]
* Episode 4 of ''SayonaraZetsubouSensei'', when Meru "speaks."
* ''SerialExperimentsLain'' had the short voiceover that started every episode: * Static* "Present day...heh heh heh...PRESENT TIME...HA HA HA HA HA-" * static*
** And then there's the "Whisper" synthesized voice that's used to say the layer titles at the beginning of each episode...
** The hum of the electric power transformers becomes ever more creepy as the series progresses.
*** Especially when it starts forming recognisable words.
* ''{{Soul Eater}}'' has plenty of creepy moments, like Ragnarok's screaming and the moments before Asura's release. In the dark, otherwise silent chamber all you can hear is the clanking of chains. And as he awakens he scratches madly at the floor with his fingers. Eek.
** [[http://www.youtube.com/watch?v=v6zAy7bFXgA Stein's insane laugh in the anime]].
* ''SpeedGrapher'': The dentist drill.
* Occurs in the ''LightNovel/HaruhiSuzumiya'' anime, when the plot just screws with the viewers head in "Remote Island Syndrome Part 2". [[http://www.youtube.com/watch?v=S06MrVt1z4I 2:01 - 2:22. Scary.]]
* The original sound novels of ''VisualNovel/UminekoNoNakuKoroNi'' have a ScareChord that will weasel its way into your head and make you [[ParanoiaFuel paranoid for hours]]. Not to mention the "got a new [=TIP!=]" sound effect, which probably sounds fine on its own but gets used in more than one terrifying context...
** The strange, hammering-on-metal the Stakes emit in their...er, stake form. It's constantly present whether it makes sense (ricocheting off walls in rapid succession) or not (flying through empty air).
** [[http://www.youtube.com/watch?v=bnH9Gbw4ybk ahaha.wav]]. When you hear it, people are going to die. There is no escape.
** That creaking door. ''That goddamn creaking door''.
** The gorram wind, either with some scary music or by itself, brr.
*** Made even worse in the VN when you have finished episode 4 and the picture to the menu shows Beato's golden land with only the empty wind as a sound. All that just to remind you what happened at the end of the episode...
* ''WolfsRain'': Cheza's screams, most likely intentional. Is that what a dog whistle sounds like to canines?
* Listen very carefully to the noise in ''Anime/YuGiOh'' right before Marik's eye appears overtop of Yami Marik's face.
* ''VampirePrincessMiyu'' has the [[CreepyMonotone absolutely deadpan, cold, unemotional voices]] of Aiko's parents in the first OAV. [[spoiler: And it's even worse when you learn that they're ''DeadAllAlong.'']]
** Whenever you hear OAV!Miyu giggle, you'll want to '''run for the hills'''.