* Corruption, violent crime and a cast full of adulterous {{Jerkass}}es can't make Bubbles walking up those stairs any less heartwarming.
* As a stone-cold killer, Wee-Bey comes across as generally warm and funny. But there's nothing like the moment where Bey agrees to give up Namond to Bunny.
-->'''Wee-Bey:''' Man came down here to say my son can be anything he damn please.
* Rawls taking [=McNulty=] aside and telling him that getting [[spoiler:Kima shot]] was not his fault, assuring him that, even though he is a "gaping asshole" that nothing that happened was his fault, and if it were, he'd be the one leading the charge for his arrest.
* [=McNulty's=] tearful apology to Kima.
* D'Angelo's final conversation with his mother in Jessup, telling her he intends to carry the weight of the Barkdales, only asking that she as well as Stringer and Avon leave him to serve his sentence in peace.
* Bubbles finally coming to terms with the death of Sharrod in a heartfelt speech to his support group.
-->'''Bubbles:''' Ain't no shame in holdin' on to grief, as long as you make room for other things too.
* Kima reciting the West Baltimore version of "GoodnightMoon" to her son Elijah
-->'''Kima:''' Goodnight Po-Po
-->'''Elijah:''' Goodnight Po-Po
-->'''Kima:''' Goodnight Fiends
-->'''Elijah:''' Goodnight Fiends
-->'''Kima:''' Goodnight Hustlers
-->'''Kima:''' Goodnight Hustlers
-->'''Kima:''' Goodnight to everybody
-->'''Elijah:''' Goodnight to everybody
-->'''Kima:''' Goodnight one and all
* The cop funerals, except for the last one. When a supporting cast member dies, their character also dies and gets a proper send off from Baltimore's Finest.
--> '''Jay Landsman:''' He came, he served, he is counted.
** Hell, the last one was pretty heartwarming too. Seeing Landsman of all people giving [[spoiler:[=McNulty=]]] a heartfelt (and even tearful) send off was sweet to see.
* Dennis "Cutty" Wise is just starting to get his boxing gym together, but all he has is beat-up old equipment that is falling apart. Knowing he'll never get a loan from a bank, he goes to the only person he knows that can fund the project: Avon Barksdale. Avon sits unimpressed and almost seemingly disinterested while Dennis does his sales pitch, and asks Dennis how much he wants. Obviously expecting rejection, Dennis asks for $10,000. Avon laughs at him for ''only'' asking for $10,000, and has Slim Charles go get Dennis $15,000 in cash, no strings attached.
-->'''Avon:''' You take care of those little niggas, you feel me?
* When Landsman, the most statistic and career concious cop in Homicide, decides to let Bubbles go, with the words "Fuck the clearance."
* [[spoiler: If you put the events of Season 5 out of your mind,]] [=McNulty=] having a stable relationship with Beadie and seeming genuinely happy during Season 4 is pretty heartwarming to see.