!!Johnny Carson's era:
* The episode from 1987 with four-year-old spelling bee star Rohan Varavadekar. The interview is both hilarious and makes you go "Awwww". Especially the moment when Rohan invites Johnny to his fifth birthday party.
* From Johnny Carson's run; the night before his final show, Bette Miller serenades him with a performance of "One More For the Road."
* Johnny's final show itself - "I bid you a very heartfelt goodnight."

!!Conan O'Brien's era:
* When Conan told about his concussion, he thanked Andy for riding with him to the hospital and keeping him company while he recovered.
* The contract negotiations with NBC for ending the series to let Leno back on the air didn't cover his stagehands, so [[http://www.huffingtonpost.com/2010/02/02/conan-paying-crew-severan_n_445721.html Conan paid them out of his own pocket for six weeks.]]

!!Jimmy Fallon's era:
* Similar to Creator/StephenColbert, one of Creator/JimmyFallon's shows had an all-soldier audience while they were on shore leave. To cap it off, he and Creator/AdamSandler sang a spoof of Creator/GarthBrooks' "Friends in Low Places" - "Friends on All Bases" - in tribute to them.
* The US women's gymnastics team from the 2016 Olympics appeared on the show to play Hungry Hungry Humans. They were greeted with a standing ovation and chants of "USA! USA!"