* Brenda takes Nate and David to the bus that caused Nathaniel's death, where the two brothers come to (better) terms with father's passing.
* Cutting straight to the heart of the show's message: Nate comforting a grieving woman:
-->'''Grieving woman''': Why do people have to die?
-->'''Nate''': To make life important.
* The entire show's "message" distilled into a few lines of dialogue. Heartwarming, Awesome, ''and'' thought-provoking:
-->'''Nate Sr.''': You can do anything, you lucky bastard, you're alive! What's a little pain compared to that?
-->'''David''': It can't be that simple.
-->'''Nate Sr.''': What if it is?
* In David's last (imagined) confrontation with season four's hitchhiker/hijacker, he attempts to deliver 'the final blow' in a dream before seeing himself in the red-hooded figure. He then embraces his other self, presumably coming to terms with his fears, and wakes to find a vision of Nate smiling over him. The ensuing, reassuring silence is particularly heartwarming.
* Nate's relationship with his daughter Maya. In particular, the moment when Maya goes to visit Nate in hospital [[spoiler:right before he dies]] and cuddles up to him is very sad and very sweet.
* "To Nate." [[spoiler: The Fishers have a toast in Nate's honour when they all have dinner together.]]
* A moment which combines Heartwarming Moment and Moment of Awesome: the last scene, which cuts between Claire driving off to New York City and flash-forwards of [[spoiler: all of the deaths of the surviving main characters]]. It's surprisingly heartwarming in context.