!!!Season 1
* Bob saving an innocent binome from deletion, at the last second, in "Racing The Clock."
* All the effort that not just Dot but effectively all of Mainframe go to in order to assemble Enzo's birthday, which, based on the audience, seems to be on the level of the largest social event in Mainframe.
* Bob and Enzo's big brother-little brother relationship is heartwarming. Enzo idolizes Bob for being Mainframe's hero, while this one acts as a cool BigBrotherMentor to Enzo and often takes him to do racing and other sports together during his free time, in addition to mentoring him during games. And despite Enzo's [[BrattyHalfPint brattiness and annoyingness]] at the beginning of the series, Bob never shows any annoyance toward him, instead keeping his charming, upbeat and friendly attitude all the time.
-->'''Enzo:''' Uh, Bob? Thanks again for spending all this time with me. Doing all this stuff with you is the coolest present I could ever access!\\
'''Bob:''' Don't mention it, Enzo, it's your first birthday. You deserve to be spoiled! Now go on, I'll be right up.
* In "Identity Crisis:Part 2", after [[spoiler:Cyrus stole the PDI's from the people of Sector One in Part One and betrayed everyone, with Megabyte lying and saying Dot gave the PDI's to him]], Dot saves the binomes with Bob's help and tries to apologize, saying she never gave up the PDI's. However, one of the binomes makes it clear that they know she tried her best and they still believe in her and what she tried to do for them, with the rest of the binomes cheering for her. This touches Dot, who, for the first half of the episode, had been so stricken by guilt [[HeroicBSOD she was barely was functioning]].

!!!Season 2
* In "When Games Collide", after Bob saves Megabyte from a tarpit in the merged game, Hack and Slash have Dot prisoner. Bob immediately reminds Megabyte he owes him and Megabyte, with barely a seconds hesitation, commands his men to let them go, having to repeat himself at his troops shocked reaction. After Bob and his friends fly away, Megabyte murmurs "Now, we are even, Guardian."
* [=AndrAIa=]'s introductory (eponymous) episode combines this with a SugarWiki/MomentOfAwesome. In the middle of the underwater game she originated in, she manages mid-game to strike up a friendship with Enzo, but in the middle of a skirmish toward the goal, Enzo is horrified to realize she's a game sprite, and his new friend will inevitably leave with the game (amplifying Enzo's frustration earlier in the episode of feeling desperately lonely with no sprites like him around the city). [=AndrAIa=] ain't going out like that, and unleashes an awesome IndyPloy - after knocking out Enzo, she downloads a backup of herself onto Enzo's icon, locks Enzo up in a torpedo and launches it toward the goal, thus [[JustInTime beating the User, winning the game,]] and saving Bob, Dot, and Enzo from being nullified. Moments later, back in Mainframe, Enzo's icon is pressed and [=AndrAIa=] materializes, becoming the first known game sprite to show up outside of a game. Her first act? [[FriendshipMoment Hugging Enzo.]] [[SandInMyEyes The screen may get a little blurry by this point.]]
** This one might have an element of FridgeHorror to it - what if that backup means that this [=AndrAIa=] is a copy of the original, who's still hopping around the Net with the original game? Or it really did back up her data on her Icon before it released her thinking she was Enzo, as she said - but either way, what [=AndrAIa=] did was incredibly sweet and the end result is no less heartwarming.
* At the end of "Mad Bob," Enzo is sad after Dot yells at him for going into the game and Bob agrees with her. But then Bob tells Enzo that he couldn't have won the game without him, making Enzo smile.
* A small moment comes towards the end of "Painted Windows". As Hex lies on the floor in the fetal position, weakened and shaking and practically catatonic, [[RightHandCat Scuzzy]] immediately rushes to her side in concern, and Bob leaves Mike the TV behind to keep her company and help her get through it. By "Nullzilla" the two of them are shown to be getting along surprisingly well.
* Slash's justification for [[MegatonPunch punching Gigabyte]] [[NiceJobBreakingItHero all the way back to Mainframe]].
--> '''Slash:''' He hurt my friend.
* Bob and Dot are cornered by Gigabyte, and it looks like it might be the end for them...
-->'''Bob:''' Dot? [[DyingDeclarationOfLove I wanted to tell you]]...\\
'''Dot:''' I know, Bob. I know.
* In "Web World Wars", we see the culmination of Bob and Enzo's relationship. Deciding that Enzo had earned becoming a Guardian like him, Bob downloads the Guardian code to his PID and, despite knowing full well that Dot wouldn't approve, appoints him his replacement as Mainframe's defender if something happens to him (Bob). What's more, it's initially implied that Bob is doing this to cover for Enzo lying to [=AndrAIa=] that he was a Guardian. But it's quickly made clear that, no, ''Enzo has genuinely earned this.''
-->'''Enzo:''' Thanks, Bob!\\
'''Bob:''' No, Enzo, you've really earned this. You will be transferred to the Supercomputer to attend the Academy and become a full-fledged Guardian like me. ''I know you'll make me proud.''
** We also get the evolution of Dot and Mouse's relationship - things had been tense between the two of them, given Mouse's history with Bob butting up against his burgeoning attraction with Dot. But between mutually saving one another's lives over the last couple of episodes, when Mouse asks if Dot will be watching her back during their "enemy of my enemy" alliance with Megabyte and Hexadecimal against the encroaching web, Dot simply motions to the non-guitar-BFG she's strapped on.
-->'''Dot:''' What do you think this is for?

!!!Season 3
* Dot being reuinited with Cecil (whom she had presumed deleted) at the end of "To Mend and Defend".
* In "Firewall", Cyrus, despite having helped with Megabyte's propaganda campaign against Enzo and previously betrayed the group in "Identity Crisis", is saved by Enzo. Enzo asks for his help to stop the User and Cyrus does, even saving Enzo's life when he falls. [=AndrAIa=]gratefully calls him a hero and kisses his forehead, with Cyrus clearly touched and happy to be considered so as the binomes all surround him and congratulate him.
* After an incursion of Megabyte's forces is repelled, leading to complete losses on his side (losses that he is completely unconcerned about), Dot retreats to her private office, crying over the senseless loss of lives. Even though these are the enemy, she is averting AMillionIsAStatistic and remembering that these binomes are [[BrainwashedAndCrazy infected by Megabyte]], acting under his control, not their own.
* When [=AndrAIa=] is near-fatally injured by a Web-Creature, Princess Bula suggests to Matrix that an energy transfusion might buy her some more time, but warns him that it ''[[UnderStatement "might hurt"]]''. His response?
-->'''Matrix:''' Do you think I care? Throw the switch!
* Matrix has to be called away from the energy transfusion he's giving [=AndrAIa=] because the ship's under attack. At the end of the episode, ''Mr. Christopher'' stumbles upstairs and we find out he'd taken it upon himself to donate energy to her during the battle. This is the same character who complained earlier in the episode about not turning a profit.
* When Matrix and the gang finally, ''finally'' find Bob in the Web, mid-season 3. And Bob even saves [=AndrAIa=]'s life for good measure. And just to cap it off, Matrix' reaction is to instinctively yell "BOB!" and nearly perform a glomp like he did when he was a BrattyHalfPint. Even after everything Matrix has been through, he's still little Enzo deep down, and wants to be close to his hero.
-->'''Bob:''' WHOA! I think you're a little too big for that!
* While the scene of Matrix pulling his gun Ray Tracer after being bumped into, trigging a PTSD-fueled moment of pure survival instinct is generally very sad, Ray's own reaction is quite sweet. While Bob and Captain Capacitor both yell and scold Matrix for it, and the Web Riders try to disarm Matrix, furthering his paranoid response, Ray remains completely calm. He tries to get the Web Riders to back down and speaks to Matrix gently and kindly. Ray never blames or holds the incident against Matrix either, understanding that he was not acting out of maliciousness.
* Captain Capacitor's kindness in helping Matrix search for Bob in the web. At one point his crew even questions what they have to gain from it and he only responds that helping Matrix is his way of repaying Dot and in doing so is more important than any valuable.
* An easily missed one due to the lighting, but in "End Prog," Mouse retrieves a binome girl's guardian teddy bear. Heartwarming enough in itself, that she pauses in the middle of the system's likely deletion to give her this little comfort, but this is the same style guardian teddy bear that we've seen Mainframers with since the show started - but it's GREEN. As in it's not in the image of Bob, but Enzo. Particularly heartwarming considering all the difficulty he had to go through to gain that acceptance, given that everything about him, from age to the fact that he's green instead of blue, was originally criticized.
** Then there's the next time you see her with it gives it more context. That time, she still has her bear, but with some orange hair added onto it. Then you realize, the bear isn't her replacing Bob with Enzo as a hero, but ''adding onto it''. The bear is a gestalt of those who helped her and as such who she looks up to. Bob's Guardian uniform, Enzo's green skin color, and Mouse's orange hair.
* In "End Prog" Ray offers to take Mouse away from the system but Mouse refuses. When she suggests for Ray to leave if he wants, he refuses as well.
* Hack & Slash arguing about whether or not to delete Cyrus as ordered by Megabyte. Gives the [[DumbMuscle idiot henchmen]] actual character and [[MinionWithAnFInEvil shows that they aren't truly evil]] (or even enjoy being mean). They liked Bob because [[MoralityPet he kept them from doing anything really bad]]. Referenced again as when Bob returns, Hack & Slash's first instinct is to run up and give him a big hug like he was family.
* Glitch, the Keytool, had one when it offered to merge with Bob when the Saucy Mare faced an impossible situation - unless they lowered the shielding they'd assembled of dead Web creatures, Mouse's countermeasures would destroy them in their programing to keep out said Web creatures, but the shields were in place to prevent the crew from degrading in the hostile environment of the Web. It seems they're stuck on the outside of Mainframe looking in, when Glitch abruptly begins to emit Keytool Speech and offers to merge with Bob. Bob makes it clear that it's something of a HeroicSacrifice, indicating that Glitch wouldn't retain at least its own individual consciousness, but Glitch is on board with getting them all home.
* Bob de-fragmenting Hex's mask in "Showdown."
** There's also her agreeing to send Bob to rejoin the others.
---> '''Hexadecimal:''' For you, Bob... anything.
** Note that he never seems anything but concerned (either for Mainframe or Hexadecimal) during this scene. He genuinely wants to help her, its not just an escape ploy. This is actually FridgeBrilliance, since in the following Season we find out that Bob was always interested in reforming viruses rather than deleting them (which was considered a radical view among Guardians). Makes perfect sense for him to be interested in helping her, [[spoiler: even if the same logic ultimately doesn't work ''at all'' for Megabyte.]]
* When Matrix explains [[YearInsideHourOutside what happened to him and [=AndrAIa=]]] to Capacitor he takes a moment to pause and say "no regrets" as he and [=AndrAIa=] stare at each other.
* Matrix and Dot reuniting doubles as a TearJerker, in a TearsOfJoy sort of way. He has the most adorable smile and her tears as she realizes her baby brother is safe and back home are just so heartwarming.
* In Matrix's nightmare, he was stuck in Megabyte's body and no matter what he said the dream version of Dot didn't recognize him. He has feared this would be the same with the real Dot, given that he no longer looked, sounded or acted like his old self. But all it took was for him to call her "sis" for Dot to unconditionally accept that he is Enzo. Even after he changed so much, Dot still recognize her brother.
** Crossing over into [[Awesome/ReBoot awesome]] for the animation team, you can see Dot's reaction change while she's looking at him. It starts off with a tactical assessment to him for the fighting ahead, to a spark of recognition, then switching between hope that it's Enzo and disbelief that it's not. All done without a single word said.
* Hack and Slash comforting each other during "System Crash" and "End Prog".
* Bob and Dot's BigDamnKiss.
* Phong comforting Dot after she cries over having been [[WhatASenselessWasteOfHumanLife forced to delete a bunch of virals.]]
* "End Prog": MAINFRAME REBORN! After a whole season of being destroyed by the war with Megabyte, the user restart's Mainframe, not only repairing the entire city, but also bringing back binomes that were deleted, even freeing the virals free of Megabyte's control.

!!!Season 4
* Dot and Hexadecimal searching for the Null that was Wellman Matrix so that Hex can restore his sapience. She fails at first, but when Dot begs her, she realizes that Wellman is in some sense her father as well and tells Dot, "I'll try again, Sis." Extra heartwarming as Dot and Hex are also romantic rivals and were enemies not long ago, yet Dot trusts Hex and Hex will do her best to make Dot happy.
** Of course, once you remember that she referred to her and Megabyte always trying to kill each other as just [[FridgeHorror sibling rivalry...]]
* Through the "Daemon Rising"arc, Hex attempts to be helpful to the team since Bob helped her. When Daemon's forces attack Mainframe, Bob(weakened by his overuse of his powers)asks Hex to stop the attacking forces without destroying anyone. Hex casually answers "Okay."and flies up before non lethally blasting the infected Guardians out of Mainframe(if only temporarily).
* Daemon's relationship with Daecon, an infected Guardian and her second in command. When he fails to capture Bob, he kneels to her and apologizes and she instantly forgives him with a kind smile on her face. Sadly, [[YouHaveFailedMe even her patience has limits]].
* Hex and Little Enzo's relationship is wonderful, with her acting as a big sister to him and them playfully interacting. She even jokingly says "I love children. I could never eat a whole one!" and it becomes a running joke between the two.
** It goes further when, just before she [[spoiler: sacrifices her life to save Mainframe]], she leaves a gift for Little Enzo. A special code that allows Nibbles to regain [[spoiler: Wellman Matrix's consciousness]]...if for no other reason than out of love for him and to keep Little Enzo from becoming like the embittered [[ParentalIssues Matrix]].
* Hex's complete acceptance of how countering Daemon's infection of the Net will require her to commit a HeroicSacrifice.
-->'''Hexadecimal:''' What's the problem? We've got a Virus, me! Give me the cure and I'll fix everything.\\
'''Bob:''' Hex, you won't survive this. It's a one-way trip. Total fragmentation.\\
'''Hexadecimal:''' But you will survive.
** And then her final words to the others.
---> '''Hexadecimal:''' Bob, I have always loved you. Dot, look after him and... [[IWantMyBelovedToBeHappy be happy.]]
* Say what you will about the restoration of Bob from his Web-damaged state back to his classic appearance, you can't fault Glitch's motivation - allowing his friend and companion to be whole again after Megabyte took some of Bob's code.
* [=AndrAIa=] might be infected by Daemon at the time, but in her casual girl talk with the supervirus, she reveals that she knew from the start that Enzo wasn't a Guardian like he claimed, that he was just trying to impress her. Reframes her referring to him as 'Guardian' while they're kids into her trying to encourage him to live up to that ideal.
* After Matrix and "Bob" beat Pantsu Hebi X, they celebrate like when Matrix was a kid. "Bob" accidentally calls him Enzo and promptly apologizes, but Matrix likes how it reminisces him of their original friendship and tells him that he's doesn't mind being called that by him. Granted, it's somewhat offset by the fact that [[spoiler: this "Bob" is actually Megabyte]]. But still, it's heartwarming that Matrix would allow [[spoiler: who he thinks is]] Bob to call him that when he doesn't let anyone else, not even [=AndrAIa=].
* Matrix praising Little Enzo for helping them win a game. "That was okay, kid" may not sound like much, but judging from Enzo's response, and [=AndrAIa's=] comment ("High praise indeed!"), it was high praise coming from him.