* Billy Gardell was deeply in debt and tired of scrabbling for parts that would get cut or recast. He turned down the role of Mike and was preparing to move his family back to Pittsburgh, where he'd lined up a job at a local radio station, when Chuck Lorre called and said that he would personally fight the network to keep Gardell as Mike because he believed that Gardell was the only person who could play the role and asked Gardell to trust him. Gardell did, Lorre kept his promise, and the show became a hit.
* From the second episode:
-->'''Mike:''' Let's see, when I picked her up she was loaded on codine and singing at the top of her lungs...\\
'''Carl:''' So far, so good.\\
'''Mike:''' She then proceeded to drink an entire bottle of ''very'' expensive wine, after which she yanked the hair out of my nose, started a fight with the waiter, and then passed out on the crapper...\\
'''Carl:''' ...That doesn't sound so good.\\
'''Mike:''' It wasn't, Carl! It was a total disaster!\\
'''Carl:''' I'm sorry... I guess you'll never see her again.\\
'''Mike:''' Are you kidding? I'm gonna ''marry'' that girl.
* Victoria's dedication to her job. Yes, she applies makeup on corpses but she does it so that the dead can leave the world in dignity.
* Mike proposes. Molly says yes.
* And then there's the whole wedding.
* The cold open of the episode "Molly in the Middle" in it's entirety is a combination of this and Moment of Funny, in which Mike and Molly discuss the possibility of having a baby. The way they work off each other in the conversation, you 100% buy they are an incredibly adorable recently-married couple.
* When Mike reads Molly's second book, the story of Peggy's life, and it brings him to tears.
--> Where are you going?
--> I'm going to go hug my mom!
* Peggy admitting that for all the things that have gone wrong in her life, the one and most important thing she got right was Mike.