->'''Bartender:''' Okay -- for you, something special. This is krogan liquor -- ryncol. You'll set off radiological alarms after you drink it. Should I pour you a quad?\\
'''Shepard:''' Hell yeah! Put more stuff in the... the thing more stuff goes in.\\
'''Bartender:''' Your funeral, pal/sister.
-->-- ''VideoGame/MassEffect2''

Examples of {{Gargle Blaster}}s in VideoGames.
* ''VideoGame/GrandTheftAutoViceCity'' features the "Love Juice", the favorite drink of the band Love Fist: 3 fizz bombs, 1 part boomshine, 3 parts trumpet, and 1 liter of petrol. Boomshine itself could be considered a Gargle Blaster. It's potent enough to intoxicate someone on the fumes alone, and if put too close to an open flame, will detonate like a weapons-grade explosive. At one point, a bottle of it is even fashioned into a makeshift pipebomb to blow up a limo. Oh, and one of its ingredients is '''battery acid'''.
* In the ''Night of the Raven'', an expansion pack for ''[[VideoGame/{{Gothic}} Gothic 2]]'' one can find a recipe for Lou's Hammer - a very strong booze with swampsharks' teeth as one of its ingredients. Drinking it for the first time will result in boosting the hero's stats. But there's also Double Lou's Hammer that does nothing except [[spoiler:depleting half of hero's life bar]]. Even Samuel, a pirate who is in charge of the alcoholic supply of the camp honestlty warns the player's character not to drink it.
* ''VideoGame/QuestForGlory''
** The series features several powerful drinks with such wonderful names as Troll's Sweat and Djinn Sling. Drinking too much has such effects as knocking you out (at which point you wake up outside the bar with your wallet missing), or outright killing you.
** ''Quest for Glory 1'' features "Dragon's Breath", which makes your character spontaneously combust if you drink it. In the fifth and final game, the Dead Parrot Inn has a rotating selection of house special drinks; one is the Dragon's Breath. After four adventures and defeating evil djinns, demons, and an EldritchAbomination, the hero is ''finally'' able to stomach it (but it still turns him fire-engine red and makes him bounce up and down like a WesternAnimation/LooneyTunes character).
* The ''VideoGame/MonkeyIsland'' series of computer games does this to grog. Instead of plain-ol' watered-down rum, it's a drink made with a variety of bizarre ingredients, which may (or may not) include ''Kerosene, Propylene, Glycol, Artificial Sweeteners, Sulphuric Acid, Rum, Acetone, Red Dye No 2., [[DevelopmentGag SCUMM]], Axle Grease, Battery Acid, and/or Pepperoni''. Needless to say, it's capable of burning holes through reinforced pewter mugs in a matter of seconds. This apparently doesn't stop it from being sold in familiar-looking red-striped soda vending machines, [[AnachronismStew despite the games being set in the 17th century]]. The unusual composition is no doubt why, in the second game, near-grog is described as being as nasty-smelling and foul tasting as the real thing, sans the alcohol, so even pre-fake-ID Guybrush is allowed to drink it. Or he would be, if the bartender hadn't just sold the last bottle to Captain Kate Capsize, who prefers to be sober when she runs her glass-bottomed boat tours.
** Hilariously, one Argentinian news channel [[http://www.youtube.com/watch?v=dP5bR1o-elg believed the aforementioned recipe to be genuine]], a fact that earned it a mention in ''VideoGame/TalesOfMonkeyIsland''.
** In ''VideoGame/MonkeyIsland2LeChucksRevenge'', one puzzle for retrieving a map piece involved having a drinking contest with a hermit named Rum Rogers, Jr. using his grog recipe, with twice the alcohol and twice the calories. No matter what, Guybrush has to drink first, and drinking it causes him to faint after flipping out. You have to dump the grog into a nearby tree and substitute it for the near-grog before sitting on the stool, therefore accepting the challenge, forcing Rogers to drink his grog and collapse after you have your turn.
* ''VideoGame/NeverwinterNights'' allows the player to engage in a drinking contest, with the final round (before the opponent passes out) being a beverage known only as scurrd. It is, from a game-rules perspective, statistically ''impossible'' for any normal human being to imbibe scurrd without losing consciousness; it requires a Constitution score one point higher than what a first-level character is capable of having. A character with magically-enhanced or dwarven constitution can safely drink the scurrd, which results in the opponent passing out, and earns the PC massive respect from his buddies. If you successfully drink it, it temporarily doubles your hit points. It's the game world spontaneously recognizing the sheer {{Badass}}ery of your feat.
* ''VideoGame/SuperRobotWars''
** Kusuha Mizuha from ''Super Robot Wars: Original Generation'' is famous for her "Health Drinks". The exact ingredients are unknown, but what is know is that a single sip is enough to knock adult men unconscious. However, once you recover you feel absolutely ''amazing''. There exists a select few (mostly aliens) who actually enjoy the taste. Most other people run in terror the moment Kusuha offers them a drink, under the cover of flat-out (but politely delivered) BlatantLies.\\\
On Ryusei's route in the first game, Ryusei actually tries to explain to Giado and the others exactly what it is that goes into a "Kusuha Special" (something having to do with ground-up gecko tails and viper venom). Naturally, this doesn't sit well with Giado ''or'' his stomach. Elzam and Arado are among the few human characters who can withstand it. Elzam, being a ChefOfIron, isn't intimidated by so-called "bad food" (he went so far as to name ''all of the ingredients''; granted, it was in the Alpha games, who have almost no translations at all), and Arado's undergone so much gene modification that he can consume almost anything that's generally edible.\\\
Surprisingly, [[Anime/MobileSuitGundamWing Heero Yuy]] drank it in ''Alpha 2'' without passing out; of course, he's MadeOfIron, so it wouldn't be surprising if he had a [[StealthPun cast-iron stomach]]. Which makes Masaki Andoh's reaction of completely passing out even more hilarious, seeing as how he and Heero [[Creator/HikaruMidorikawa share a seiyuu.]] ''Divine Wars'' follows up on this for more hilarity: [[spoiler:After using a Cyflash to take out the Divine Crusaders' enemy forces at Aidoneous Island, he is exhausted due to how Cybuster's attacks work (long story). Since Cybuster is still needed, Shiro and Kuro produce a bottle of Kusuha's health drink; Masaki immediately recovers in order to ''avoid the health drink''.]] Even aliens who happen to be stone-cold badasses are not necessarily immune; [[spoiler:Ingram]] had a few moments of what must have amounted to an alien version of "oh god oh god I'm gonna die". Although, the ''Divine Wars'' version of this incident had [[spoiler:Ingram]] sound like [[spoiler:he]] [[http://www.youtube.com/watch?v=pKHcwXOuZRQ was having]] [[DoesThisRemindYouOfAnything a giant orgasm]].\\\
Lamia Loveless, an ''android'', is incapacitated by the drink. Her first assumption is that they found out she was a spy and tried to poison her. Actually, she suspected as much before drinking it, but was absolutely ''positive'' afterwards.
** Come ''2nd Original Generation'', [[Characters/SuperRobotWarsOriginalGeneration Ing Egret]] and [[VideoGame/SuperRobotWarsDestiny Ventus]] said that the drink ''is delicious''. When [[{{Delinquent}} Michiru Hanaten]] drinks it, he claims that it's so bitter though he doesn't pass out but that was because it was only a ''super mild edition''.
* ''VideoGame/{{World of Warcraft}}''
** The game has you construct several of these on various quests. How potent they truly are really depends on what level the quest is, although the quest giver will always act like it's the strongest stuff out there.
** The actual GargleBlaster of the game is the Sulfuron Slammer. It's so strong, it ''sets you on fire when you drink it''.
** To quote Harkkan; "Thundermar ale is [[UpToEleven 220 proof]]; I don't know how that's possible."[[note]]220 proof is 110% alcohol[[/note]]
** There's the new Tikaria & [=K.A.Y.T.=]. It consists of Troll Rum, mixed with Kiwi, Apple, [[BreadEggsSquick Yellow #42]] and Tangerine.
* ''GemstoneIV'' introduced a blackout-inducing drink called Eldreth's Death-rum, based on a real player-made concoction served during a gaming convention room party. Several employees watched as a brave attendee offered to try the stuff, pronounced it "not that bad" and started to walk away with no ill effects -- before suddenly dropping to his knees five steps later.
* The potion maker in ''VideoGame/TheLegendOfZeldaTheWindWaker'' uses a welding mask as described above when mixing up new potions. The process also involves small explosions and clouds of colored smoke. Link burps up a small puff of colored smoke after drinking one.
* ''VideoGame/KingdomOfLoathing'' has a number of potent alcoholic beverages.
** Such as the Pan-''Dimensional'' Gargle Blaster. Drinking it gives you the message "You feel like your head ''is'' a gold brick with a slice of lemon wrapped around it."
*** However, this drink is a failed ''inversion'' of the trope. The Pan-Dimensional Gargle Blaster is designed to cause absolutely none of the traditional GargleBlaster effects; it shunts all of them to an AlternateSelf in a parallel universe (hence the name). Unfortunately, it turns out that if you're the sort of person who would drink one, the odds are amazingly good another you will be drinking one at the same time, so...
** There are a number of suitably dodgy drinks available in the clan dungeon Hobopolis, including fermented pickle juice, "squeeze"[[note]]Sterno with the denaturing additives filtered out[[/note]] and the booze available from the hobo marketplace in the Hobopolis Town Square.
** When raiding the mini-fridge in the sunken party yacht at Spring Break Beach, you can find the Ultimate Mind Destroyer, which does exactly that. You can't drink it yourself, but you can give it one of the shop owners at the beach, causing them to completely forget whatever quests you did for them.
* When the MMO ''VideoGame/AsheronsCall'' added brewing as an ItemCrafting ability it became possible to brew "Tusker Pus", a beer so horrible it does 9999 damage when drunk, several times more damage than a player character can possibly have hit points.
* If you go to visit the nurse's office in ''VideoGame/{{Persona 3}}'' while tired or sick, the whackjob who runs it (who also teaches a class on ''magic'', mind you) offers you a concoction that is made of a number of poisonous substances and some good-luck charms (including rabbit's feet... ''in a drink''). If you choose ''not'' to drink it, he gives you actual medicine; if you drink it, it boosts your Courage, because he congratulates you on having the guts to try.
* White Gull is one of the few potions ''VideoGame/TheWitcher'' can brew that isn't instantly lethally toxic to mortals. It can be brewed from any alcohol available, and makes the ideal base for any other potions. Even with his Witcher resistance to toxins, just one will make Geralt drift across the floor like a bobber on a fishing line, two will get him 86'd to wake up on the cobbles. Non-Witcher humans won't get through one. There is no canonical evidence of how much a dwarf can drink. It's sometimes used as an anesthetic on those already near death.
* ''VideoGame/SpaceQuest 6'' and the fan-made prequel ''Space Quest 0'' feature "Coldsaurian Brandy," an extremely potent and disgusting liquor (it has a rotting fish in the bottom of the jug). Roger doesn't ''drink'' the stuff, but it makes a mean MolotovCocktail, and it's good for poisoning purposes.
* In ''VideoGame/{{Atelier Annie|Alchemists of Sera Island}}'', nobody knows exactly what it is in Gillian's drinks, but know that the stench is so powerful it could fell a field of Punies from a mile away, so they (especially Annie and Pepe) don't go near the stuff. Gillian is oblivious to this sort of reaction, and guzzles her own concoctions like water.
* In the video game of ''Film/MontyPythonsTheMeaningOfLife'', one puzzle requires you to get KarlMarx hammered, with a combination of several potent liquors, topped off with ''[[{{Squick}} spoiled chocolate milk]]''.
* ''VideoGame/DragonAgeOrigins'' has a list of dangerously potent alcoholic drinks the PC can give to Oghren (or Wynne, though Wynne prefers wine). The only drinks that ''don't'' count as gargle blasters are the watered-down ale and the wine. And the brandy. More amazingly, in ''Awakening'' Oghren is able to easily shrug off the darkspawn blood (and other mysterious-and-horrible ingredients) used for the Joining ritual of the Grey Wardens with a loud burp and a claim that it was "Not bad", while other characters either pass out and have freakish nightmares or die hideous deaths.
** For reference, The Warden, your character, passed out and had the nightmares when s/he undertook the Joining.
** In Origins, Oghren can offer you a taste of his homemade brew once you've completed his personal quest. Unless you have enough points sunk into Constitution, it'll knock you out.
* ''Franchise/MassEffect''
** The Dark Star bar on the Citadel in the second game serves the Commander "batarian ale - uncut". The bartender has never seen anyone drink it and remain standing. Shepard, of course, orders another one, at which point the bartender gives him/her a ryncol, below. The aftermath of Shepard's binge-drinking in the Dark Star is undoubtedly the most amusing part, with the Commander waking up on the men's room floor sometime later while a Turian relieves himself at one of the urinals. Doubly hilarious if your Shepard is female.
** Then there's "ryncol", the krogan drink of choice. Said drink is said to have the effect of paint thinner on non-krogan. Shepard is knocked out by it. Then again, Shepard [[{{Cyborg}} isn't quite human]] [[BackFromTheDead anymore]]. Grunt's recommendation on ryncol is "Don't try to act tough -- that stuff'll go through a human's insides like broken glass." The Darkstar bartender informs you when you order one that you'll be setting off radiation alarms for a week. And note that Shep drank it when s/he was already noticeably inebriated.
-->''"This is...[[ShoutOut it's]] [[StarTrek green]]?"''
** In the ''Citadel'' DLC of the third game, it's shown that ryncol is so strong that it can function as a MolotovCocktail ''[[UpToEleven without being lit on fire first]].''
** ''Citadel'' also contains a reference to drinks called turian horosk and a volus bina. Turian horosk is not being served because the establishment wants their guests entertained instead of comatose (Turian physiology is incompatible with most of the galaxy—anything we consume is dangerous to them and vice versa, though this particular drink is implied to be extremely strong even for turians). A volus bina meanwhile will put you on the floor with its alcohol content while the ammonia will let you clean up after yourself. If you survive (that said, volus can't drink ryncol, period; seems it comes back out in ugly ways, if one is to believe an analogy about a leaky mech).
** ''Citadel'' also also contains a rather disgusting cocktail that's three parts horse-choker and one part mouthwash, made by Joker for a drinking contest to keep Cortez from dragging him out to the shooting range later. (Joker wins, he doesn't go.) Cortez manages about two shots and gives up from the taste alone, [[ItTastesLikeFeet which he poetically compares to a goat's ass]].
** The [[CoolOldLady bartender]] on Illium in the second game can, if asked the right questions, recollect about a time when she saw a krogan drink a ''blended turian'' on a dare. Given that turians have MirrorChemistry compared to most life in the galaxy (quarians are the only other sentient life with the same chemistry), well... "[[NoodleIncident Nobody one came out of that one looking pretty]]."
* Yet another one for BioWare: Tarisian Ale in ''KnightsOfTheOldRepublic'' is brewed with glands from a monkey-like critter. There's an optional sidequest where some low-ranking Sith mooks serve it at a party. You and Carth apparently don't partake, as the two of you are the only ones in the room ''conscious'' after the party-goers drink it.
* In ''VideoGame/NellyCootalot'', the Barnacle Bar offers several drink with questionable names. Things like ''Texas Medicine'' and ''Admiral Nosehair's Old Unsanitary'' come to mind.
* ''VideoGame/TeamFortress2'' is silent about the composition of the Demoman's "Scrumpy", but general fan opinion is that it's some sort of Gargle Blaster, very likely self-distilled (one of the maps is Granary, and one of the Demoman's teammates is a borderline MadScientist Engineer from Texas...).
** The description for [[http://wiki.teamfortress.com/wiki/Whiskey_Bib one item]] indicates that, even scrumpy not being enough, the Demo has even started drinking ''[[https://en.wikipedia.org/wiki/Methanol woodgrain alcohol]].''
** [[http://wiki.teamfortress.com/wiki/Spent_Well_Spirits One of his taunts]] has him chugging a cocktail of his scrumpy and ''the powder from one of his grenades''.
* ''VideoGame/BraveSoul'' has a cocktail called the "Lady Killer" which the bartender claims to be almost 100% alcohol [[CriticalResearchFailure (which would make it impossible for it to be a cocktail)]]. [[TheHero Rudy]] is knocked out. Alicia claims it tastes like juice.
* ''VideoGame/FinalFantasyX'': Whatever is in Auron's jug is not to be trifled with considering in his [[LimitBreak Overdrive]] he spits it onto his BFS, ''which causes dark fire and '''black holes'''''. Another has Auron creating a whirlwind and then hurling his entire jug in, at which point the tornado turns into a fiery pillar. A level of FridgeBrilliance when it comes to the alcohol: [[spoiler:He's ''already dead'', so that's why he can handle it]].
* ''VideoGame/{{Fallout}}''
** The series has a number of alcoholic beverages and narcotics that give temporary benefits to the player, such as increasing their combat speed, making them more resistant to damage, or raising their charisma (one of the amusing side effects of alcohol). There's a TruthInTelevision moment in that your character can become addicted, and once the effects of the drugs wear off his/her stats are reduced until s/he is either cured of addiction by a doctor, or s/he takes another hit. It's surprisingly fun to play as a junkie.
** The ''VideoGame/FalloutNewVegas'' DLC "Dead Money" introduces the "[[http://fallout.wikia.com/wiki/Sierra_Madre_martini Sierra Madre Martini]]", created by Dean, a Ghoul who's been in the Sierra Madre for two centuries and had time to experiment. It's created via brewing the residue of the poison cloud that permeates the place with a bag of [[http://fallout.wikia.com/wiki/Junk_food potato chips]] in a rusty tin can. Tastes hideous, highly addictive and gives some pretty nifty buffs.
** There is but one drink that can beat a Serra Madre Martini... the awesome Large Wasteland Tequila. At 100 survival skill it gives you +9 strength, +3 charisma, and -9 intelligence. (The maximum stat level is 10 and the minimum stat level is 1.) It makes you as strong and as ''stupid'' as statistically possible unless you have the Whiskey Rose perk when you drink it. Sweet Jesus.
** So basically if you have Cassidy as a companion when you drink it, it'll turn from a GargleBlaster into a SuperSerum.
* In VideoGame/ImprobableIsland, you can buy one in the pub in the capital city. Those who drink one tend to wake up covered in other people's blood.
* ''VideoGame/TheElderScrollsVSkyrim''
** The player can enter into a drinking competition [[spoiler:with what turns out to be Sanguine, the Daedric Prince of debauchery]]. The brew is apparently strong enough that the Dragonborn wakes up on the other side of Skyrim with no memory of the previous night, having experienced all manner of wacky adventures.
** Talen-Jei, the waiter at the Bee and Barb inn, dabbles in making cocktails. The Cliff Racer, a blend of Firebrand Wine, Cyrodiilic Brandy, Flin, and Sujamma, fits this trope closest, but the Velvet [=LeChance=] deserves an honorable mention for being garnished with Deadly Nightshade (albeit a nonlethal quantity).
** In ''VideoGame/TheElderScrollsIIIMorrowind'', Ancient Dagoth Brandy can be found, and its effects include (semi)permanent reductions to both intelligence and willpower, with no benefits to show for it. Considering the drinks have likely been fermenting in the presence of plague-infested evil for a few hundred years, its potency is understandable.
** Also in Skyrim, with the Dawnguard expansion. They introduced Redwater Skooma, in a Skooma house. Which immediately knocks the drinker out, only to be dragged down to the basement to become a Vampire's Thrall. Interestingly your companion is locked up with you, despite not drinking any.
* In ''VideoGame/BuffyTheVampireSlayerChaosBleeds'', Faith might muse about ''drinking'' bottles of fire intended to kill vampires.
* Bottles of liquor found in ''VideoGame/SystemShock 2'' are usually somewhere around 250% proof, but they are graded after effect rather than alcohol content, and contain a number of other drugs that simulate the effects of alcohol.
* ''VideoGame/HeroesofNewerth'': One of the Engineer's skill involves throwing a large explosive keg, stunning and knocking back any targets hit. According to the skill description, he drinks this stuff.
* In ''VideoGame/{{NieR}}'', one sidequest requires you to prepare a special drink for Popola so she can work up the nerve to sing alongside Devola. The bartender says Popola is the only one that can stomach it. The ingredients include ''lizard tails and rat tails''.
* In ''VideoGame/ReturnToZork'' one puzzle (That may seem familiar to fans of Monkey Island 2) has you visiting the town drunk, which you need to knock him out on his own rye to get his keys and unlock the trapdoor to access the next part of the game. The puzzle involves making a toast (Saying the correct words for the drunk's personal toasting ritual, which he won't comply if you mess up) dumping the drink in the plant (He's too drunk to notice) and repeat. He can take up to three mugs, but one will knock you out.
* In ''VideoGame/StarshipTitanic'', you have to get the bartender to make one and then drink it. The ingredients include a crushed television set and a flock of pureed starlings.
* In "VideoGame/GalaxyOnFire2", in the Supernova expansion, there is a certain alcohol introduced into the story, discovered and served by Mkkt Bkkt, that causes those who drink it to start sputtering random noises (it sounds rather like they are reading the noises from a comic page out loud rather than imitating the sounds). This happens mere SECONDS after the first sip, about four or five seconds to be more precise. To top it all off, the only way to cure the effects without waiting a rather long amount of time involves a type of frog venom that can VIOLENTLY EXPLODE if it's even shaken around too much.
* One of the liquor bottles on a shelf in ''VideoGame/NeverwinterNights'' mod ''Demon'' contains a substance called Scurrd. Its description is rather...interesting.
-->What is in Scurrd? What, indeed. Scurrd just seems to find the way to where it can do the most harm. It's truly vicious.\\
It cannot be smelled by the elderly...\\
It cannot be held by small children...\\
It is Scurrd, and woe be to [[YeOldeButcheredEnglish ye that take it to ye tongue]].