* Chapter 1:
** Kowai's perfect description of Yotsuba to Fuuka:
-->'''Kowai''': If you see a girl that makes you think "it's a weirdo!", that's probably her.
** Ena's first encounter with Yotsuba. After teaching Yotsuba how to play on the swings, Ena leaves the park, turns to see what Yotsuba's doing... and sees her ''really high up''.
-->'''Ena''': Your hands! Your hands! Don't let go of those chains!
-->'''Yotsuba''': ''[[TemptingFate (holds up her hands)]]'' My hands?
-->'''Ena''': ''(makes a terrified expression while watching Yotsuba fly off... who thankfully lands safely in the sandpit)''
** Fuuka's first encounter with Yotsuba... is when the latter is ''climbing up an utility pole'', pretending to be a cicada. She then exclaims, "[[CallBack It's a weirdo!]]"
*** The Finnish translation tops it off. Yotsuba says "Olen kaskas" ("I'm a cicada"), which isn't funny yet. The thing is, "kas kas" is a common way to say "is that so?", which is exactly what Fuka says next, making this an [[IncrediblyLamePun epicly lame pun]]. It's like Kiyohiko Azuma wrote the line expecting the eventual Finnish translation.
* Chapter 2:
** Fuuka getting stuck in the Koiwais' bathroom window... not long after Koiwai did the exact same thing.
** And then being made fun of by Asagi, who also brings out Ena just to have a good laugh.
* Chapter 4:
** Yotsuba playing with the tape measure, more specifically when she asks a distracted Fuuka to hold it while she gets enough distance and sends the tape flying. Dad was not happy.
** Jumbo first meeting [[LoveAtFirstSight Asagi]].
-->'''Asagi''': It must be hard to find clothes your size.
-->'''Jumbo''': NOT REALLY! BECAUSE BEING NAKED IS OK FOR ME TOO!
--> *blank stare*
** Jumbo's random "GAOO!" at Ena, followed by her running away and tripping.
** When Ena tells her family about the 'huge guy', they know EXACTLY who she's talking about.
-->'''Fuuka/Mom/Asagi:''' Jumbo-san./Giraffe-san./Takeda-san.
-->'''Asagi & Fuuka:''' ''Giraffe''-san?
-->'''Mom:''' He said his ancestors were giraffes...
* In Chapter 6, Yotsuba showing off the cicadas she and her friends caught to their mom - [[HilarityEnsues by opening the box of bugs, setting them free inside their house]]. It can be reminiscent of the many similar mistakes of any troper's childhood.
** "After that we went cicada hunting in Ena's house."
* Chapter 7 when Koiwai randomly put the underwear on his head. That and everything else involving "Pants Man!!" (A.K.A. "Boxer Man"), including Pants Man's later nemesis, Bare-Butt Man - Yotsuba's [[CaptainObvious sense of humor is]], well, [[ExactlyWhatItSaysOnTheTin so five-years-old]].
* Chapter 9 has Yotsuba, after watching a gangster movie, going on a revenge rampage on her father, Jumbo and the neighbors with her water pistol. From squirting down her own father in cold blood, to taking out one of Ena's teddy bears (while saying [[HypocriticalHumor she doesn't kill chidren]]), to the part where [[CoolBigSis Asagi]] gets the drop on her and gives her a taste of her own medicine.
* Chapter 12, "Yotsuba and the Pool":
** Fuuka pushes Jumbo in the pool and makes fun of him for not being able to swim. Koiwai defends him, and so Fuuka also pushes him too and finds out he also can't swim. She laughs at the two of them... and then Yotsuba ''also'' pushes her in, and it's shown [[HypocriticalHumor she also can't swim.]]
-->'''Koiwai''': So, you can't swim either.
-->'''Fuuka''': Yes. Sorry.
** Yotsuba as a swimming instructor
-->'''Yotsuba''': Let's start with pike.
-->'''Koiwai, Jumbo, Fuuka''': ........
-->'''Yotsuba''': You have to think about the fish!
-->'''Caption''': Yotsuba's swimming dojo - unsuccessful.
* Chapter 13 has Yotsuba stalking her prey, Fuuka's reaction to the frog, Koiwai's visitor, and the ReactiveContinuousScream from Miura, Ena and Yotsuba at the end.
* Asagi's [=CDs=] for her father in chapter 14.
-->'''Asagi''': Hm... I wasn't thinking when I bought these. Dad... isn't... with us anymore, is he?
-->''[Asagi and Mrs. Ayase look out the window as if mourning his death]''
-->'''Fuuka''': No, no, no. Dad is ''alive''. He's working right now.
-->'''Ena''': Asagi always likes to kill Dad off.
* Chapter 18:
** Koiwai dressing Yotsuba up as the Flower Cupid.
-->'''Koiwai''': Very cute! Just like the Literature/LittleMatchGirl.\\
'''Yotsuba:''' Ahh, the one who sets houses on fire?\\
'''Koiwai''': No, not at all. Which one is that?
** Also a mix of CrowningMomentOfHeartwarming, when the Flower Cupid came home to heaven.
* Chapter 19:
** [[ItMakesSenseInContext Koiwai biting Yotsuba's head]].
** The "It's HUGE!" moment when they arrive at the zoo.
** [[ItMakesSenseInContext Yotsuba punching the goat]].
** Koiwai "translating" for the elephant.
--> '''Yotsuba''': "OHHHHH! You can tell what the elephant is saying!?"
--> '''Koiwai''': "You bet I can! What else is a translator for? ''I am an elephant! From Africaaa!''"
--> '''Yotsuba (reading from sign)''': "In. Di. An. Ele. Phant."
--> '''Koiwai''': "[[VisibleSilence ...]] Okay, sorry. Daddy was making that up."
* Any time Koiwai and Jumbo face off. Like when they were playing Badminton in chapter 22.
-->'''Koiwai''': KIEEE!!
-->'''Jumbo''': KUAAAA!!
-->'''Koiwai''': CHOO
-->'''Jumbo''': CHAA
-->'''Koiwai''': HAUAAA
-->'''Jumbo''': HOIYAA
-->'''Yotsuba''': [[GetOnWithItAlready Hurry up and play]].
-->'''Koiwai & Jumbo''': Ok. Sorry.
* Chapter 23 has Jumbo going berserk when he finds out Miura is going to Hawaii.
-->'''Jumbo:''' And now our little princess will perform a hula dance!
-->'''Ena:''' '' ''
-->'''Miura:''' STOP THAT!
* Chapter 25:
** Yotsuba attempts to cure Fuuka's heartbreak, after Fuuka has seen her crush hand in hand with another girl... unfortunately Yotsuba's advice is under the influence of Asagi, and so includes such gems as ''"Asagi's never known heartbreak!"'', ''"You have fat legs!"'' and ''"Your thighs are pudgy, too!"''.
** When Fuuka tries to explain heartbreak to Yotsuba. She asks her who she likes, and she replies with, "[[DaddysGirl Daddy!]]" Fuuka asks her to imagine her dad not liking her anymore... Yotsuba takes it too seriously and ''really'' tears up at the thought of it, and Fuuka quickly reassures her her dad loves her.
* In Chapter 27, Yotsuba finding out from Asagi and revealing to Dad what tsukutsukuboshi ''really'' are.
* Chapter 30
** Yanda's introduction, beginning an instant rivalry with Yotsuba. [[PokeThePoodle He bites her ice cream,]] she trolls his phone conversation, and then he prank calls her. Basically, their first meeting introduces the funniest rivalry ever.
** '''[[ItMakesSenseInContext THIS POOP IS DELICIOUS!]]'''
** "DAMN YOU, YANDA!"
*** '' '''NEVER COME BACK.''' ''
* Chapter 31, "Yotsuba & the Stars"
** Yotsuba blinding herself with the "Yotsuba Beam!" and stumbling backwards into a trash can and blaming Yanda, who's ''not even with them.''
** Koiwai asking Yotsuba if she knows any stars:
--> '''Koiwai''': Are there any stars you know, Yotsuba?
--> '''Yotsuba''': There is!
--> '''Koiwai''': Oh, which one?
--> '''Yotsuba''': Um... that bright, pretty one.
--> ''*Yotsuba points up at the sky*''
--> '''Koiwai''': Which star is it?
--> ''*Next panel*''
--> '''Yotsuba''': Earth.
* Chapter 41:
** Yanda's [[http://bato.to/read/_/5334/yotsubato_v6_ch41_by_azunites/14 arrival]] and Yotsuba's reaction:
-->'''Yotsuba:''' A nasty guy arrived!
-->'''Jumbo:''' Ah true, a nasty guy arrived.
-->'''Koiwai:''' A nasty guy arrived.
-->'''Yanda:''' ...Give me a break.
** A little later, they take a break and Jumbo gets hamburgers. In an adorable, and hilarious, moment, Yotsuba maliciously eats hers at Yanda, who only had cup ramen.
* In Chapter 46, when Yotsuba is shopping for ramen, she says, "With this much, I figure even if I ate it once a week, I could still have it every day." Another shopper has a hilarious look on her face as she tries to comprehend that sentence.
* In Chapter 47, [[http://bato.to/read/_/17727/yotsubato_v7_ch47_by_veers/27 the faces Yanda makes]] when Yotsuba is trying to get a ticket from a toll booth (and poor Yotsuba's subsequent reactions).
* Chapter 48, the farm chapter:
** Yotsuba trips and falls down the hill, smashing her head on a sheep. Both Yanda and Jumbo laugh at her, but Yotsuba just does a grumpy victory sign to Yanda. And then she apologises to the sheep, it attacks her with its head, and ''then'' Yotsuba punches it in the face.
** When Yotusba is going to [[RunningGag punch a cow]] to prove to Yanda that she's not a coward.
** When the gang are being taught by the tour guide how to milk the cow:
-->'''Yotsuba''': I know how to count to five!
-->'''Yanda''': I also know how to count to five.
-->'''Jumbo''': I know how to count as well!
-->'''Koiwai''': So do I.
-->'''Tour guide''': H-how nice...
** Yanda's talking to a cow.
--> '''Yanda''': [[http://bato.to/read/_/17729/yotsubato_v7_ch48_by_veers/21 Your face is huge.]]
* Chapter 54: "BUTT!"
** *smack* "BUTT!"
* Yotsuba discovering [[IncrediblyLamePun the bitter truth]] about [[http://bato.to/read/_/44381/yotsubato_v9_ch58_by_veers/2 coffee]] in chapter 58.
* [[http://bato.to/read/_/44382/yotsubato_v9_ch59_by_veers/30 Chapter 59]] shows that one should never be Yotsuba's (or Duralumin's) enemy.
* Pop quiz! What's something you go see, is large and round, and flies through the air?
--> '''Yotsuba''': A [[{{Gamera}} turtle]]!
* Yotsuba drops her newly-acquired teddy bear from a hot air balloon. Lesson about taking better care of one's possessions? Not... quite.
-->'''Torako:''' ''(stunned)'' '''''IT LANDED ON ITS FEET!'''''
* The aftermath of the balloon chapter is hilarious, especially given the ShipTease Azuma introduces, combined with Jumbo's [[http://bato.to/read/_/44388/yotsubato_v10_ch65_by_veers/3 crush on Asagi]]:
--> '''Koiwai''': "If I tell Jumbo that I went out with Asagi, he's gonna be pissed."
--> ''*Jumbo walks in*''
--> '''Jumbo''': "Yo."
--> '''Koiwai''': "I went out with Asagi."
--> '''Jumbo''': '''"''WHAT!?''"'''
** And then [[http://bato.to/read/_/44388/yotsubato_v10_ch65_by_veers/6 later]]:
--> ''*Jumbo sees a photo of Asagi and Koiwai twirling around, joined at the hands* ''
--> '''Jumbo''': ''[[ItMakesSenseInContext "YOUR HANDS!!!"]]''
--> ''*Jumbo grabs Koiwai's hands* ''
--> '''Jumbo''': ''"LIKE THIS!?"''
--> ''*Jumbo starts twirling around with Koiwai* ''
--> '''Jumbo''': "''LIKE THIIIS!?''"
* Chapter 67:
** Yotsuba finds an electric razor and immediately tests it out on Jumbo's beard. [[RapeOfTheLock Jumbo is horrified.]]
** Yotsuba [[http://www.mangareader.net/132-54916-23/yotsubato/chapter-67.html headbanging]].
* Pretty much the entirety of [[http://www.mangareader.net/yotsubato/69/24 Chapter 69 pt 2]], but special mention goes to Miura's little attempt at wisdom on the first page:
-->'''Miura:''' Robot or not, all living things must die
-->beat
-->'''Miura:''' Even though he's not a living thing...Since he's a robot...
* Volume 11 adds a bonus section to chapter 72, featuring Yotsuba, Dad, and Jumbo hiding when Yanda comes round. Badly. And then Yanda hides himself ''too''.
** There's also this:
-->'''Yotsuba''': But Daddy ate so much that he turned into Full Belly Man.
-->'''Jumbo''': What does he do when he's Full Belly Man?
-->'''Yotsuba''': He doesn't move.
* Chapter 76 is melancholy, as Yotsuba is lamenting over Juralumin no longer speaking. Fuuka decides she'll pretend to be Juralumin by proxy as a way to cheer her up. Yotsuba's "what the heck is your deal?" look is priceless.
* In Chapter 80, the HalloweenEpisode, Fuuka wonders if Halloween being a Christian holiday [[InsaneTrollLogic means it was invented by Jesus.]] When she's told it's not, she guess it was probably someone else, like '''Gandhi.'''
* Yotsuba and Ena pretend to be fancy ladies while camping:
-->'''Ena''': Lady Yotsuba, dost thine eyes see what lies thither?
-->'''Yotsuba''': Heavens, what could it be? My stars, it's a river! It looks ever so refreshing!
** and then later...
-->'''Yotsuba''': Is this where hillbillies live?
-->'''Miura''': Heavens, that won't do at all. A lady of your stature saying such things.
-->'''Yotsuba''': Goodness! You must forgive me.
* Yotsuba, Ena and Miura playing in the hammock.
** Then when Mr. Koiwai wants them to help with dinner, Yotsuba asks him to push them again and, without saying a word, he unceremoniously flips the entire hammock over.
* Miura standing behind everyone else and ringing her bear bell... at a cat.