* In the Serena Williams episode, the [[TinyGuyHugeGirl obvious size difference between Serena and Wayne]] gets lampshaded right off the bat:
-->Colin as Serena's voice: "...let's see what you got, ''little man!''"\\
Wayne: (DeathGlare at Colin)
** Even before that:
--> Colin as Serena: "Let me start by saying three things. First of all, I'm a princess. (Serena hams along) Secondly, if you start yelling at me, I will cry. (Serena goes predictably sad.) [[BreadEggsMilkSquick Thirdly, if you keep yelling at me I will kill you.]]"
* The Jack and Kelly Osbourne episode. Two guests at once has the bonus of their own interactions adding to the humor. Of special note, the "First Date"-inspired game only has one bell and horn this time, leading to Kelly snatching them from Jack to state her point of view, so to speak.
* The whole Creator/RickyGervais episode, especially since you really don't expect Ricky to become the ButtMonkey right off the bat.
-->Ricky: [[SlippingAMickey (examining his drink) "I feel like someone slipped me some crack..."]]\\
[[CrossesTheLineTwice (Wayne fesses up)]]