* If you try entering a vehicle from the driver's side that already has a driver in it, they'll notice and make fun of you.
* In the opening cutscene:
-->'''Krusty''': Hey hey kids! I'm endorsing a new cola and [[NoodleIncident this one]] [[BlatantLies isn't poisonous]] ''to anybody!''
-->'''Announcer''': That we know of.
* This gem:
--> '''Bart''': I've gotta get the new Bonestorm game or I'll be as uncool as Milhouse!
--> '''Milhouse''': I'm standing right here, Bart.
* In Level 2, as Bart is collecting illegal fireworks to join the recent fad, he talks to Moe.
--> '''Moe''': Sorry, Bart. I can't sell booze to a minor. It ain't right.
--> '''Bart''': I'm here to buy fireworks.
--> '''Moe''': Oh, hell yeah!
* Pretty much all of Ralph's dialogue in the races.
--> '''Apu''': Hey, aren't you the boy who nearly drowned in nacho cheese?
--> '''Ralph''': I was in the newspaper!
* In Level 1, one of Homer's missions is to return things to Ned, one of them is a cooler he gave to Barney:
--> '''Homer''': [[NoodleIncident Uh, remember that cooler I gave you for your birthday?]] Well, Flanders wants it back
--> '''Barney''': Now what will I use for toilet?!?!?
* When buying the Plow King from Barney:
--> '''Homer''': Barney, can I borrow the Plow King?
--> '''Barney''': Take what you want, sexy leprechaun, just don't shoot me with a dart gun!
--> '''Homer''': Whatever
* Mr. Burns initially thinks Homer is a former business partner he murdered: "Wow, that was really...wow."
* At the end of level 5, Bart and Apu learn that [[spoiler: Buzz Cola is going to send everyone into a murderous frenzy to boost the rating of a reality tv show.]] Bart's thoughts?
--> '''Apu''': We must prevent the [[spoiler: aliens]] from putting laser guns in the hands of cola drunk towns people.
--> '''Bart''': Why? [[ComedicSociopathy That sounds awesome!]] [[ComicallyMissingThePoint I'd watch that show.]]
--> '''Apu''': *Face palms* Tell you what: you're a bad little boy.