* "Hai, doggy!"
** Even funnier because the lady seems to be one line behind in the script.
* When Johnny has just had a fight with Lisa, and furiously talks to himself before noticing his friend Mark is there.
-->'''Johnny:''' I did nat heet her, it's naht true, it's bowlshit! I did naht heet her! [[ChewingTheScenery I did NAAAAAHT.]] [[MoodWhiplash Oh hai, Mark.]]
* "Anyway, how is your sex life?"
** This is uttered immediately after Johnny claims he can't talk to Mark about what's going on at work because "[[HypocriticalHumor it's confidential]]".
* "And she's showing everybody [[Main/SmartPeopleSpeakTheQueensEnglish me underwears.]]"
* "You are tearing me APART Lisa!!"
** [[WebVideo/CinemaSins "There's nothing wrong with this scene. This scene is gold"]]
* The fight scene for some strange reason. The dialogue by Johnny definitely helps.
** "Don tosh meh, motorfocker! Geddaut!"
** "I'LL KILL YOU I BREAK EVERY BONE IN YO BODY! I KILL YOU YOU BASTURD!"
* "''[[ObligatorySwearing Shit]]''[[LameComeback , alright!?]]"
* "I ''definitely'' have breast cancer."
** [[AngstWhatAngst "Don't worry about it!"]]
* "In a few minutes, [[ThisIsForEmphasisBitch bitch]]."
* "Did you get your promotion?"
** "''Nah.''"
** "...You didn't get it, didn't you?"
* The entire pot smoking scene.
* "[[ComicallyMissingThePoint Johnny doesn't drink!]]" This is said immediately after Lisa tells her mother about ''DomesticAbuse''.
* The scene where Lisa gets Johnny drunk on a combination of [[GargleBlaster scotch and vodka]], capped off with Johnny in 'drunk' mode, which is less convincing than the average ten year old pretending to be drunk;
-->'''Johnny''': I'm tie-erred, eye'm waysted, I luhrff you duurhling.
* "Where's my FUCKING MONEY, DENNY!?!"
** "YOU'RE NOT MY FUCKING MOTHER!"
** "WHAT THE HELL'S WRONG WITH YOU?!"
** "STOP GANGING UP ON ME!"
* "Chicken, Peter, you're just a little chicken. CHEEP-cheep-cheep-cheep-cheep-cheep-cheeeeEEEeeeeeEEEeeeeauaa."
** Even more hilariously brought up later (during the fight scene) with, "You betrayed me, you're not good. You-- You're just a chicken! CHEEP-CHEEP-CHEEP-CHEEP-CHEEP!" He also looks stiff as a board when he does the chicken movements.
* Speaking of Peter, the fact that, due to his actor's having to leave the project midway and that Wiseau insisted upon filming the infamous "football in tuxes" scene over the actually-important party scenes, the character's last lines are, "[[spoiler: That's it, I'm done,]]" is all the more hilarious.
* "What a story Mark." It's how badly dubbed it is and [[DissonantLaughter how inappropriate the laugh is for the story]] that makes it hilarious.
* "Wow, you look great! You look... a baby face..."
** The extreme close up of Mark's newly shaven face, compelled with the dramatic music, as if it were supposed to be a shocking reveal. Greg Sestero called this one of the most embarrassing things he had ever done.
* Another great piece of dialogue:
-->'''Lisa''': He got drunk last night and he hit me.
-->'''Michelle''': He hit you?!
-->'''Lisa''': He didn't know what he was doing.
-->'''Michelle''': Are you okay?
-->'''Lisa''': Well, I don't want to marry him anymore.
-->'''Michelle''': What?!
* The drama of [[spoiler:Johnny's suicide]] is ruined by a single line
-->'''Mark''': As far as I'm concerned, you can drop off the earth! That's a promise.
* EVREYBODY BEETRAYED ME! I'M FEDDAP WIT THIZ WOROLD!
* So leave your '''STUPID''' comments in your pocket!
* "Let's goh eat, HAAAUUU!"
* The swooning romanticism of Mark and Lisa's interactions:
-->'''Lisa''': I miss you.
-->'''Mark''': I just saw you, what are you talking about?
* "Denny, don't cook too much, it may not come out right." Johnny's response to Denny's drug problems.
* Lisa and Mark's reactions to [[spoiler:finding Johnny's body after he decides "[[Podcast/{{Rifftrax}} Oh hai, gun barrel!]]"]].
-->'''Mark''': WAKE UP [[spoiler:JOHNNY]]! WAKE UP!
-->'''Lisa''': OH MY GOD, MARK, [[spoiler:IS HE DEAD?]]
* Johnny's facial expression and silly wiggling of the tape when he shows it to Lisa. It's a lot less "I've got the evidence right here, you bitch!" and more like he's mildly smug.
* Despite hitting the DespairEventHorizon, Johnny decides to mourn the fact that his fiancé had been cheating on him by...humping her red dress.
* Rotten Tomatoes' summary of the movie.
--> A benevolent, friendly, selfless man who greets everyone with a disarming "Hi" discovers that you can't trust anyone after getting engaged to a manipulative, self-serving siren who seduces his best friend and destroys his life in The Room. Johnny (writer/director Tommy Wiseau) has everything a man could ever want: great friends, a good job, and a gorgeous fiancée named Lisa (Juliette Danielle). But Lisa's innocent act masks the fact that she's looking to bring Johnny down, and her manipulations are tearing Johnny apart. As Lisa informs her cancer-ridden mother, Claudette (Carolyn Minnott), that Johnny hit her (he did not hit her, that is bull$&*t, he did not), Johnny's best friend, Mark (Greg Sestero), finds his resistance to Lisa's seductive charms weakening. Meanwhile, local orphan Denny (Philip Haldiman) looks up to Johnny, and needs the older man's help after the teen rips off a drug dealer. What kind of drugs? It doesn't matter. Then guys play football in tuxedos, because you can play football anywhere.
* "It's okay he just wanted some money." "What kind of money?!"
** [[CaptainObvious "That was a very dangerous man! He had a gun!"]]
----