* Right when the original boots up, you hear Sam exclaim (in a hilariously rough/gravely voice): "[[BadassBoast Sam I Am!!!!!!]]"
* "[[http://www.youtube.com/watch?v=CjpMmW53JnY&t=9m40s To be or not to be... that is a serious question.]]"
* This line from the BFE trailer, which may double an AwesomeMoment:
-->'''Sam''': It's not over until I [[BeatingADeadPlayer teabag]] ''every last one of you alien [[PrecisionFStrike motherfuckers.]]''
* The [[http://www.youtube.com/watch?v=pSiV3b1enjI secret watcher]] in ''Second Encounter'', especially when you [[SchmuckBait shoot at it]].
* In Before First Encounter, the entire cutscene of [[spoiler: Sam blowing up the Sphinx and his ensuing argument with Quinn]] is one big CrowningMomentOfFunny.
* This scene from ''BFE''':
--> '''Headless Kamikaze:''' AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAHH!!!
--> ''Sam kills the headless kamikaze''
--> '''Sam:''' AAAAAAAAAAH--- put a sock in it.
--> ''Hordes of headless kamikazes approach''
--> '''Hordes of Headless Kamikaze:''' '''''AAAAAAAAAAAAAAAAAAAAAAAAAHHHHHHH!!!'''''
--> '''Sam:''' [[OhCrap Uh oh.]]
** This is a callback to a similar scene from The First Encounter, with the only change being Sam's one-liner to the first Kamikaze. "AAAAAAAAAAAAAAAAAHHH yourself!"
* Also from BFE, there's the cutscene where Sam locates Professor Stein's phone [[spoiler: next to his severed arm.]] Quinn had been calling, and when Sam responds, telling her that [[spoiler: Stein is dead]], she asks if he found his phone.
--> Sam: "You mean the phone you just called??"
--> Quinn: "Uh... right."
* "Jesus Harold Faltermeyer Christ!"
* In ''TSE'', there are several rooms which have [[GravityScrew gravity fields that propel enemy mooks (and the player) around from wall to wall]]. The game also supports doppler shifting of sounds. The rooms are full of kamikaze bombers. You can see where this is going.